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https://www.readbyqxmd.com/read/29129819/nicotinic-acetylcholine-receptor-%C3%AE-7-subunit-improves-energy-homeostasis-and-inhibits-inflammation-in-nonalcoholic-fatty-liver-disease
#1
Dong-Jie Li, Jian Liu, Xia Hua, Hui Fu, Fang Huang, Yi-Bo Fei, Wen-Jie Lu, Fu-Ming Shen, Pei Wang
OBJECTIVE: Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases worldwide; yet, the pathogenesis of the disorder is not completely understood. The nicotinic acetylcholine receptor α7 subunit (α7nAChR) plays an indispensable role in the vagus nerve-regulated cholinergic anti-inflammatory pathway. METHODS: In the present study, we investigated the key role of α7nAChR in NAFLD development. Male wild-type (WT) and α7nAChR knockout (α7nAChR(-/-)) mice were fed a normal chow or a high-fat diet (HFD) for 16 weeks to induce NAFLD...
November 9, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29128339/rs6923761-gene-variant-in-glucagon-like-peptide-1-receptor-allelic-frequencies-and-influence-on-cardiovascular-risk-factors-in-a-multicenter-study-of-castilla-leon
#2
D A de Luis, M Ballesteros, A Lopez Guzman, E Ruiz, C Muñoz, M A Penacho, P Iglesias, A Maldonado, V Puigdevall, M Delgado
BACKGROUND: Some GLP-1 receptor studies have identified polymorphisms in the GLP-1 receptor gene that might be related to different cardiovascular risk factors. OBJECTIVE: Our aim was to investigate the allelic distribution of rs6923761 GLP-1 receptor polymorphism in a geographic area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients...
November 2, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29124049/effect-of-personalized-nutritional-counseling-on-the-nutritional-status-of-hemodialysis-patients
#3
In-Young Jo, Woo Jeong Kim, Hyeong Cheon Park, Hoon Young Choi, Jung Eun Lee, Song Mi Lee
This study set out to evaluate the impact of personalized nutritional counseling (PNC) on the nutritional status of hemodialysis (HD) patients. This was an intervention study for 10 months at 2 hospitals. Anthropometric, biochemical, dietary, and body composition parameters were measured at baseline and after 3 and 6 months of PNC. A total of 42 patients (23 men and 19 women) were included. Intake of dietary protein, serum albumin, and cholesterol levels had increased significantly from baseline to month 6 (p < 0...
October 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29117670/association-between-dietary-intake-and-postlaparoscopic-cholecystectomic-symptoms-in-patients-with-gallbladder-disease
#4
Yongju Shin, Dongho Choi, Kyeong Geun Lee, Ho Soon Choi, Yongsoon Park
Background/Aims: After cholecystectomy, patients have reported postcholecystectomic syndromes such as abdominal symptoms, dyspepsia, and diarrhea, which suggest a relationship between cholecystectomic symptoms and diet, although the details of this association remain unclear. The present study investigated the hypothesis that dietary intake of nutrients and foods was significantly associated with postcholecystectomic syndromes. Methods: Gallstone patients (n = 59) who underwent laparoscopic cholecystectomy were enrolled, and dietary intake and clinical parameters were assessed immediately postcholecystectomy and 3 months later...
November 10, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29116147/spexin-suppress-food-intake-in-zebrafish-evidence-from-gene-knockout-study
#5
Binbin Zheng, Shuisheng Li, Yun Liu, Yu Li, Huapu Chen, Haipei Tang, Xiaochun Liu, Haoran Lin, Yong Zhang, Christopher H K Cheng
Spexin1 (SPX1) is a newly discovered neuropeptide in vertebrates. Its biological function remains to be elucidated. In this study, we have generated the zebrafish spx1 (-/-) mutant lines using transcription activator-like effector nucleases. Phenotypes of the spx1 (-/-) mutant zebrafish were analyzed in order to understand the effects on reproduction and food intake. The reproductive capability is not impaired in spx1 mutant zebrafish. However, we found that the spx1 (-/-) mutant fish had a higher food intake than the wild type (WT) fish...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29105526/effect-of-omnivorous-and-vegan-diets-with-different-protein-and-carbohydrate-content-on-growth-and-metabolism-of-growing-rats
#6
Gianluca Giuberti, Mauro Morlacchini, Luca Crippa, Jessica Capraro, Beatrice Paganini, Antonio Gallo, Filippo Rossi
The purpose of this study was to observe, in a rat animal model, the short and medium term effects of vegan (VEG) or omnivorous (OMNI) diets with different energy partition between nutrients (zone or classic). Six different diets were administered, for 72 days to 120 growing male Sprague-Dawley rats: (i) VEG zone diet; (ii) VEG classic diet; (iii) OMNI zone diet; (iv) OMNI classic diet; (v) OMNI zone diet with added fibre and (vi) OMNI classic diet with added fibre. Zone diets (high protein and low carbohydrates), resulted in better growth , feed efficiency, lower blood glucose and insulin responses...
November 5, 2017: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29072970/dipteryx-alata-vogel-may-improve-lipid-profile-and-atherogenic-indices-in-wistar-rats-dipteryx-alata-and-atherogenic-indices
#7
Adriana Maria Ragassi Fiorini, Sandra Maria Barbalho, Élen Landgraf Guiguer, Marie Oshiiwa, Claudemir Gregório Mendes, Rogério Lopes Vieites, Agnaldo Bruno Chies, Priscilla Bianca de Oliveira, Maricelma da Silva Soares de Souza, Claudia Cristina T Nicolau
Worldwide prevalence of noncommunicable chronic degenerative diseases is among the main causes of death worldwide. The consumption of some foods such as nuts and seeds may be beneficial in preventing these diseases. Dipteryx alata Vogel (DA), known popularly as Baru, belongs to the family Fabaceae and is a native fruit tree from the Brazilian savanna. The purpose of this study was to evaluate the use of seeds of DA on the metabolic and oxidative profile of Wistar rats. Animals were divided randomly into four groups (n = 10): G1 (control group), and G2 (treated with DA 20%), G3 (treated with DA 30%), and G4 (treated with DA 40%)...
October 26, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29071106/equivalent-reductions-in-body-weight-during-the-beef-wise-study-beef-s-role-in-weight-improvement-satisfaction-and-energy
#8
R D Sayer, K J Speaker, Z Pan, J C Peters, H R Wyatt, J O Hill
OBJECTIVE: The objective of this randomized equivalence trial was to determine the impact of consuming lean beef as part of a high protein (HP) weight-reducing diet on changes in body weight, body composition and cardiometabolic health. METHODS: A total of 120 adults (99 female) with overweight or obesity (BMI: 35.7 ± 7.0 kg m(-2)) were randomly assigned to consume either a HP diet with ≥4 weekly servings of lean beef (B; n = 60) or a HP diet restricted in all red meats (NB; n = 60) during a 16-week weight loss intervention...
September 2017: Obesity Science & Practice
https://www.readbyqxmd.com/read/29054469/the-acidity-of-early-pregnancy-diet-and-risk-of-gestational-diabetes-mellitus
#9
Sahar Saraf-Bank, Hotav Tehrani, Fahimeh Haghighatdoost, Seyedeh Parisa Moosavian, Leila Azadbakht
BACKGROUNDS & AIMS: Recently, an increasing interest has been addressed to the acid-base imbalance in the pathogenesis of diabetes while we are not aware of any study among patients affected by gestational diabetes mellitus (GDM). Therefore, the purpose of present study was to reveal the potential relation between dietary acid load (DAL) and glycemic indices, lipid profiles and GDM odds ratio among Iranian pregnant women with GDM. METHODS: This case-control study (hospital-based setting) was performed in singleton fetus pregnant women; healthy (n = 263) and GDM (n = 200), aged 22-44 years, and between weeks 5-28 of pregnancy...
October 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29050438/effects-of-rearing-systems-on-laying-performance-egg-quality-and-serum-biochemistry-of-xianju-chickens-in-summer
#10
X Y Dong, Z Z Yin, Y Z Ma, H Y Cao, D J Dong
The objective of this study was to compare the laying performance, egg quality, and serum biochemistry of hens maintained in conventional cage rearing system (CRS), flat net-rearing system (NRS), and free range system (FRS) under summer conditions. Indigenous Xianju chickens (n = 540) were randomly allocated into cages or pens of rearing system groups, within each system there were 5 replicates with 36 hens in each replicate. The experiment lasted between 21 and 29 wk of age. Hen-day egg production (P = 0.00) and egg mass (P = 0...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29034644/the-effect-of-eicosapentaenoic-acid-on-the-serum-levels-and-enzymatic-activity-of-paraoxonase-1-in-the-patients-with-type-2-diabetes-mellitus
#11
Mohammad Hassan Golzari, Saeed Hosseini, Fariba Koohdani, Ali-Akbar Saboor Yaraghi, Mohammad Hassan Javanbakht, Niyaz Mohammadzadeh-Honarvar, Mahmoud Djalali
Paraoxonase 1 is known as one of the most important ant oxidative enzymes associated with HDL-c, and because of its antioxidant and antiinflammatory activities. EPA has the antioxidant, anti inflammatory, antithrombogenic, and antiarteriosclerotic properties. Therefore, we investigated the effect of EPA supplementation on the serum levels and activity of PON1 in type 2 diabetic patients. This study was designed as a randomized, double-blind, and placebo-controlled clinical trial. Thirty-six patients with type 2 diabetes were given written; informed consent randomly was classified into 2 groups...
August 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/29034440/risperidone-induced-metabolic-dysfunction-is-attenuated-by-curcuma-longa-extract-administration-in-mice
#12
Florent Auger, Françoise Martin, Olivier Pétrault, Jennifer Samaillie, Thierry Hennebelle, Mohamed-Sami Trabelsi, François Bailleul, Bart Staels, Régis Bordet, Patrick Duriez
Antipsychotics, such as risperidone, increase food intake and induce alteration in glucose and lipid metabolism concomitantly with overweight and body fat increase, these biological abnormalities belong to the metabolic syndrome definition (high visceral adiposity, hypertriglyceridemia, hyperglycemia, low HDL-cholesterol and high blood pressure). Curcumin is a major component of traditional turmeric (Curcuma longa) which has been reported to improve lipid and glucose metabolism and to decrease weight in obese mice...
October 16, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29026411/healthy-eating-index-and-cardiovascular-risk-factors-among-iranian-elderly-individuals
#13
Nafiseh Rashidipour-Fard, Majid Karimi, Sahar Saraf-Bank, Mohammad Hassan Baghaei, Fahimeh Haghighatdoost, Leila Azadbakht
BACKGROUND: Concurrent with increase in life expectancy, the prevalence of chronic diseases such as cardiovascular diseases (CVD) has also increased. Therefore, the aim of this study was to evaluate the association between healthy eating index (HEI) score and CVD risk factors among Iranian elderly. METHODS: This cross-sectional study was performed on a sample of elderly persons from Isfahan, Iran, in 2013. Totally, 107 retired subjects were entered in statistical analysis...
March 2017: ARYA Atherosclerosis
https://www.readbyqxmd.com/read/29021712/chronic-dietary-ginseng-extract-administration-ameliorates-antioxidant-and-cholinergic-systems-in-the-brains-of-aged-mice
#14
Mi Ra Lee, Jin Yeul Ma, Chang Keun Sung
BACKGROUND: Black ginseng has a more potent biological activity than non-steamed ginseng. We investigated the effects of long-term intake of dietary black ginseng extract (BG) on antioxidant activity in aged mice. We also compared the effects of BG on cognitive deficits with those of white ginseng extract (WG) and red ginseng extract (RG). METHODS: Ten-month-old mice were fed an AIN-93G-based diet containing 10 g/kg (low dose, L) or 30 g/kg (high dose, H) WG powder, RG powder, or BG powder for 24 wk...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29020051/a-combination-of-plasma-phospholipid-fatty-acids-and-its-association-with-incidence-of-type-2-diabetes-the-epic-interact-case-cohort-study
#15
Fumiaki Imamura, Stephen J Sharp, Albert Koulman, Matthias B Schulze, Janine Kröger, Julian L Griffin, José M Huerta, Marcela Guevara, Ivonne Sluijs, Antonio Agudo, Eva Ardanaz, Beverley Balkau, Heiner Boeing, Veronique Chajes, Christina C Dahm, Courtney Dow, Guy Fagherazzi, Edith J M Feskens, Paul W Franks, Diana Gavrila, Marc Gunter, Rudolf Kaaks, Timothy J Key, Kay-Tee Khaw, Tilman Kühn, Olle Melander, Elena Molina-Portillo, Peter M Nilsson, Anja Olsen, Kim Overvad, Domenico Palli, Salvatore Panico, Olov Rolandsson, Sabina Sieri, Carlotta Sacerdote, Nadia Slimani, Annemieke M W Spijkerman, Anne Tjønneland, Rosario Tumino, Yvonne T van der Schouw, Claudia Langenberg, Elio Riboli, Nita G Forouhi, Nick J Wareham
BACKGROUND: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. METHODS AND FINDINGS: We measured plasma phospholipid fatty acids by gas chromatography in 27,296 adults, including 12,132 incident cases of T2D, over the follow-up period between baseline (1991-1998) and 31 December 2007 in 8 European countries in EPIC-InterAct, a nested case-cohort study...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28994516/the-implication-of-combat-stress-and-ptsd-trajectories-in-metabolic-syndrome-and-elevated-c-reactive-protein-levels-a-longitudinal-study
#16
Zahava Solomon, Yafit Levin, Einor Ben Assayag, Orit Furman, Shani Shenhar-Tsarfaty, Shlomo Berliner, Avi Ohry
OBJECTIVE: This study sheds light on the importance of long-term follow-up of trauma survivors, posttraumatic stress disorder (PTSD) trajectories, and early detection of health risk factors in trauma survivors. The present study prospectively assessed the following over 23 years: (1) the association of psychological and physiologic stress during captivity with elevated C-reactive protein (CRP) levels and metabolic syndrome (MetS), which includes hypertension; elevated levels of insulin, triglycerides, and fasting glucose; decreased levels of high-density lipoprotein cholesterol; and obesity and (2) the implication of PTSD trajectories in elevated CRP levels and MetS...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28993159/prevention-of-cholesterol-gallstone-disease-by-schaftoside-in-lithogenic-diet-induced-c57bl-6-mouse-model
#17
Meijing Liu, Changhui Liu, Hao Chen, Xiaotao Huang, Xiaohui Zeng, Juncheng Zhou, Suiqing Mi
Schaftoside (SS) is a bioactive compound present in the Herba Desmodii Styracifolii (DS), a herb that has been used to treat cholelithiasis and urolithiasis in Chinese medicine. Whether SS inhibits cholesterol (Ch) gallstone formation has not been investigated. This study examined the effects of oral intake of SS on Ch gallstone formation in C57BL/6 mice fed a lithogenic diet. The rate of gallstone formation was recorded. Levels of Ch, triglycerides (TG) and bile salts (BS) were measured in the bile and serum...
October 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28988560/effects-of-replacement-of-moringa-oleifera-for-berseem-clover-in-the-diets-of-nubian-goats-on-feed-utilisation-and-milk-yield-composition-and-fatty-acid-profile
#18
A E Kholif, G A Gouda, O A Olafadehan, M M Abdo
Replacement of conventional feedstuffs with cheap non-conventional ingredients may improve livestock performance and the quality of their products, particularly milk. The study considered the effects of Moringa oleifera (MO) foliage in replacement of berseem clover (BC) on feed utilisation and lactational performance in Nubian goats. A total of 16 lactating Nubian does, weighing 36.2±0.8 kg, were randomly assigned to four experimental treatments containing 0, 125, 250 and 375 g of MO per kg diet to replace 0 (M0), 25 (M25), 50 (M50) and 75% (M75) of BC (on dry matter (DM) basis) in a quadruplicated 4×4 Latin square design...
October 9, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28986580/fenugreek-supplementation-during-high-fat-feeding-improves-specific-markers-of-metabolic-health
#19
Eric J Knott, Allison J Richard, Randall L Mynatt, David Ribnicky, Jacqueline M Stephens, Annadora Bruce-Keller
To assess the metabolically beneficial effects of fenugreek (Trigonella foenum-graecum), C57BL/6J mice were fed a low- or high-fat diet for 16 weeks with or without 2% (w/w) fenugreek supplementation. Body weight, body composition, energy expenditure, food intake, and insulin/glucose tolerance were measured regularly, and tissues were collected for histological and biochemical analysis after 16 weeks of diet exposure. Fenugreek did not alter body weight, fat mass, or food intake in either group, but did transiently improve glucose tolerance in high fat-fed mice...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28978343/dietary-food-patterns-and-glucose-insulin-homeostasis-a-cross-sectional-study-involving-24-182-adult-americans
#20
Mohsen Mazidi, Andre Pascal Kengne, Dimitri P Mikhailidis, Peter P Toth, Kausik K Ray, Maciej Banach
AIM: To investigate the association of major dietary patterns with glucose and insulin homeostasis parameters in a large American sample. The association between dietary patterns (DP) derived via principal components analysis (PCA), with glucose/insulin homeostasis parameters was assessed. The likelihood of insulin resistance (IR) across the DPs quarters was also explored. METHOD: The United States National Health and Nutrition Examination Survey (NHANES) participants during 2005-2012 were included if they underwent measurement of dietary intake as well as glucose and insulin homeostasis parameters...
October 4, 2017: Lipids in Health and Disease
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