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Threonate AND Balding

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https://www.readbyqxmd.com/read/21034532/preventable-effect-of-l-threonate-an-ascorbate-metabolite-on-androgen-driven-balding-via-repression-of-dihydrotestosterone-induced-dickkopf-1-expression-in-human-hair-dermal-papilla-cells
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Mi Hee Kwack, Ji Sup Ahn, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung
In a previous study, we recently claimed that dihydrotestosterone (DHT)-inducible dickkopf-1 (DKK-1) expression is one of the key factors involved in androgen-potentiated balding. We also demonstrated that L-ascorbic acid 2-phosphate (Asc 2-P) represses DHT-induced DKK-1 expression in cultured dermal papilla cells (DPCs). Here, we investigated whether or not L-threonate could attenuate DHT-induced DKK-1 expression. We observed via RT-PCR analysis and enzyme-linked immunosorbent assay that DHT-induced DKK-1 expression was attenuated in the presence of L-threonate...
October 2010: BMB Reports
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