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https://www.readbyqxmd.com/read/28319104/diabetes-consequences-in-the-fetus-liver-of-the-non-obese-diabetic-mice
#1
M B Aires, A C V Dos Santos, M S Kubrusly, A C de Lima Luna, L A C D'Albuquerque, D A Maria
DM type 1 (T1D) incidence is increasing around 3% every year and represents risks for maternal and fetal health. The objective of this study was to explore the effects of diabetes on fetus liver cells in non-obese diabetic (NOD) mice. Hyperglycemic NOD (HNOD), normoglycemic NOD (NNOD) and BALB/c females were used for mating, and the fetus livers were collected at 19.5 gestation day (gd). HNOD group had reduced fetal weight (989.5±68.32 vs 1290±57.39 mg BALB/c, P<0.05) at 19.5 gd and higher glycemia (516...
March 20, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/28315443/progesterone-modulates-diabetes-hyperglycemia-induced-changes-in-the-central-nervous-system-and-sciatic-nerve
#2
Fahim Atif, Megan C Prunty, Nefize Turan, Donald G Stein, Seema Yousuf
We investigated the effect of progesterone (P4) treatment on diabetes/hyperglycemia-induced pathological changes in brain, spinal cord and sciatic nerve tissue in male rats. Animals were rendered hyperglycemic by a single dose of streptozotocin (STZ). P4 treatment was started after hyperglycemia was confirmed and body weight and blood glucose levels were monitored once/week for 5 weeks. Rats underwent behavioral testing at week 5 and were then euthanized for histology. We assessed the expression of markers of angiogenesis (vascular endothelial growth factor (VEGF)), inflammation (interleukin-6 (IL-6)) and tissue injury (CD11b, NG2, COX2 and matrix metalloproteinase-2 (MMP-2)) in the brain, spinal cord and sciatic nerve...
March 14, 2017: Neuroscience
https://www.readbyqxmd.com/read/28306534/ameliorative-potential-of-blighia-sapida-k-d-koenig-bark-against-pancreatic-%C3%AE-cell-dysfunction-in-alloxan-induced-diabetic-rats
#3
Oluwafemi Adeleke Ojo, Basiru Olaitan Ajiboye, Adebola Busola Ojo, Babatunji Emmanuel Oyinloye, Oluwatosin Debbie Imiere, Oluwatosin Adeyonu
Background In West Africa, the fruit, seed, leaf and stem of Blighia sapida K.D. Koenig are commonly used as remedy against a variety of diseases, including diabetes mellitus. This study investigated the ameliorative potential of B. sapida K.D. Koenig stem bark ethanol extract against pancreatic β-cell dysfunction in diabetic rats. Methods Diabetes was induced by intraperitoneal injection of alloxan (65 mg/kg body weight) for 21 days, and orally administered with glibenclamide (5 mg/kg body weight), 50-150 mg/kg body weight of B...
March 17, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28303338/blood-glucose-kinetics-and-physiological-changes-in-a-type-1-diabetic-finisher-of-the-ultraman-triathlon-a-case-study
#4
Christopher W Bach, Daniel A Baur, William S Hyder, Michael J Ormsbee
PURPOSE: To investigate the blood glucose kinetics and physiological effects experienced by a type 1 diabetic (T1D) finisher of a 3-day, multi-stage ultra endurance triathlon consisting of a 10 km swim and 144.8 km bike (stage 1), a 275.4 km bike (stage 2), and an 84.4 km run (stage 3). METHODS: The athlete self-monitored blood glucose (SMBG) levels via fingerstick blood draw and hand-held glucometer. Researchers evaluated blood glucose kinetics via a continuous glucose monitoring device...
March 16, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28303331/implication-of-vegf-and-aquaporin-4-mediating-m%C3%A3-ller-cell-swelling-to-diabetic-retinal-edema
#5
Teruyo Kida, Hidehiro Oku, Taeko Horie, Masanori Fukumoto, Yoshitaka Okuda, Seita Morishita, Tsunehiko Ikeda
PURPOSE: Aquaporin 4 (AQP4), a water channel protein, is known to be expressed in retinal Müller cells. The purpose of this study was to determine the effects of VEGF and AQP4 channels on the volumetric changes in Müller cells. METHODS: Retinas from diabetic rats and a cultured Müller cell line, TR-MUL5, were used in this study. Intravitreal injections of VEGF or PBS were performed on either streptozotocin (STZ)-induced diabetic or normoglycemic rats. Retinal sections were immunostained for anti-glial fibrillary acidic protein (GFAP), anti-AQP4, and anti-VEGF...
March 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28303040/assessment-of-maillard-reaction-evolution-prebiotic-carbohydrates-antioxidant-activity-and-%C3%AE-amylase-inhibition-in-pulse-flours
#6
Nadia Moussou, Marta Corzo-Martínez, María Luz Sanz, Farid Zaidi, Antonia Montilla, Mar Villamiel
In this paper, the quality of bean, chickpea, fava beans, lentil and pea flours from Algeria has been evaluated. Maillard reaction (MR) indicators, modifications in the carbohydrate and protein fractions, antioxidant activity and α-amylase inhibitor of raw, toasted and stored samples were evaluated. Fava beans, beans and peas showed higher content of raffinose family oligosaccharides while chickpeas and lentils showed higher polyol content. Toasting and storage caused slightly change in pulse quality; MR showed slight losses of lysine but increased antioxidant activity...
March 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28301595/mir-146a-regulates-glucose-induced-upregulation-of-inflammatory-cytokines-extracellular-matrix-proteins-in-the-retina-and-kidney-in-diabetes
#7
Shali Chen, Biao Feng, Anu Alice Thomas, Subrata Chakrabarti
Hyperglycemic damage to the endothelial cells (ECs) leads to increased synthesis of inflammatory cytokines. We have previously shown miR-146a downregulation in ECs and in the tissues of diabetic mice. Here we investigated the role of miR-146a, in the production of specific inflammatory cytokines and extracellular matrix (ECM) proteins in retina and kidneys in diabetes. We generated an endothelial specific miR-146a overexpressing transgenic mice (TG). We investigated these mice and wild type (WT) controls with or without streptozotocin (STZ) induced diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28296255/breg-dependent-islet-transplant-tolerance-is-also-nk-cell-dependent
#8
Christian Schuetz, Kang Mi Lee, Ryan Scott, Lisa Kojima, Laura Washburn, Liye Liu, Wei-Hui Liu, Haley Tector, Ji Lei, Heidi Yeh, James Kim, James F Markmann
Immunologic tolerance to solid organ and islet cell grafts has been achieved in various rodent models using antibodies directed at CD45RB and Tim-1. We have shown that this form of tolerance depends on regulatory B-cells. To elucidate further the mechanism by which Bregs induce tolerance we investigated the requirement of NK and NKT cells in this model. To do so, hyperglycemic B6, μMT, Beige or CD1d(-/-) mice received Balb/c islet grafts and treatment with the tolerance inducing regimen consisting of anti-CD45RB and anti -TIM1...
March 10, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/28293391/gestational-diabetes-leads-to-down-regulation-of-cdk4-prb-e2f1-pathway-genes-in-pancreatic-islets-of-rat-offspring
#9
Zahra Nazari, Mohammad Nabiuni, Mohsen Saeidi, Mohammad Jafar Golalipour
OBJECTIVES: The link between a hyperglycemic intrauterine environment and the development of diabetes later in life has been observed in offspring exposed to gestational diabetes mellitus (GDM), but the underlying mechanisms for this phenomenon are still not clear. Reduced β-cells mass is a determinant in the development of diabetes (type 1 and type 2 diabetes). Some recent studies have provided evidence that the CDK4-pRB-E2F1 regulatory pathway is involved in β-cells proliferation...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28292576/association-of-polymorphisms-of-peroxisome-proliferator-activated-receptors-in-early-and-late-onset-of-type-2-diabetes-mellitus
#10
Resal Raj, Jasvinder Singh Bhatti, Sanjay Kumar Bhadada, Pramod W Ramteke
OBJECTIVE: Genetic variation of disease susceptible genes is different in different ethnic groups and there is an evidence of association of polymorphisms of Peroxisome Proliferator Activated Receptors (PPARs) in Type 2 Diabetes Mellitus (T2DM). This research analyses the association of PPARs in early and late onset of T2DM in North Indian Population (NIP). METHODS: Total of 703 subjects were recruited from north of India and subjects were further divided into subjects of early onset (less than 25 years of onset, 26 T2DM and 26 controls) and late onset (more than 25 years of onset, 326 T2DM and 325 controls)...
March 6, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28288147/gestational-hyperglycemia-reprograms-cardiac-gene-expression-in-rat-offspring
#11
Lara Lehtoranta, Anna Koskinen, Olli Vuolteenaho, Jukka Laine, Ville Kytö, Hanna Soukka, Eeva Ekholm, Juha Räsänen
BACKGROUND: Rat fetuses with maternal pregestational hyperglycemia develop cardiac dysfunction and their cardiac gene expression differs from healthy control fetuses near term. HYPOTHESIS: Cardiac gene expression and morphologic abnormalities of rat fetuses with maternal pregestational hyperglycemia become normal after birth. METHODS: Nine rats were preconceptually injected with streptozotocin to induce maternal hyperglycemia and 9 rats served as controls...
March 13, 2017: Pediatric Research
https://www.readbyqxmd.com/read/28287807/all-cause-and-cardiovascular-mortality-following-treatment-with-metformin-or-glyburide-in-patients-with-type-2-diabetes-mellitus
#12
Mohammad Reza Raee, Arash Aghajani Nargesi, Behnam Heidari, Mohammad Ali Mansournia, Mehrdad Larry, Soghra Rabizadeh, Mitra Zarifkar, Alireza Esteghamati, Manouchehr Nakhjavani
BACKGROUND: Both metformin and sulfonylurea (SU) drugs are among the most widely-used anti-hyperglycemic medications in patients with type 2 diabetes mellitus (T2DM). Previous studies have shown that treatment with SUs might be associated with decreased survival compared with metformin. This study aimed to evaluate all-cause and cardiovascular mortality rates between glyburide and metformin in patients diagnosed with T2DM. METHODS: This was a cohort study on 717 patients with T2DM (271 undergoing monotherapy with glyburide and 446 with metformin)...
March 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28283910/hyperglycemia-impedes-definitive-endoderm-differentiation-of-human-embryonic-stem-cells-by-modulating-histone-methylation-patterns
#13
A C H Chen, Y L Lee, S W Fong, C C Y Wong, E H Y Ng, W S B Yeung
Exposure to maternal diabetes during fetal growth is a risk factor for the development of type II diabetes (T2D) in later life. Discovery of the mechanisms involved in this association should provide valuable background for therapeutic treatments. Early embryogenesis involves epigenetic changes including histone modifications. The bivalent histone methylation marks H3K4me3 and H3K27me3 are important for regulating key developmental genes during early fetal pancreas specification. We hypothesized that maternal hyperglycemia disrupted early pancreas development through changes in histone bivalency...
March 10, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/28282223/analytical-methods-for-metformin-estimation
#14
Durgawati Patel, Puspendra Kumar, Jaya Dwivedi, Swapnil Sharma
Metformin is a widely prescribed oral anti-hyperglycemic agent used in the management of noninsulin dependent diabetes mellitus (NIDDM) or type II diabetes. This article accentuates various analytical methods viz. HPLC, HPTLC, spectrophotometric, electrochemical, capillary electrophoresis and LC-MS for the estimation of metformin in pharmaceutical formulations and in biological matrices.
March 10, 2017: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/28279595/effect-of-a-dosing-time-on-quetiapine-induced-acute-hyperglycemia-in-mice
#15
Snehal Kapse, Hitoshi Ando, Yuki Fujiwara, Chisato Suzuki, Kentaro Ushijima, Hiroko Kitamura, Keiko Hosohata, Kazuhiko Kotani, Shigeki Shimba, Akio Fujimura
Although rare, second-generation antipsychotic drugs cause severe hyperglycemia within several days after the initiation of therapy. Because glucose tolerance exhibits circadian rhythmicity, we evaluated an effect of a dosing-time on quetiapine-induced acute hyperglycemia in mice. A single intraperitoneal dose of quetiapine dosing-time-independently induced insulin resistance in fasted C57BL/6J mice. However, acute hyperglycemic effect was detected only after dosing of the drug at the beginning of an active phase...
February 17, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28277867/the-role-of-the-new-basal-insulin-analogs-in-addressing-unmet-clinical-needs-in-people-with-type-1-and-type-2-diabetes
#16
Rosemarie Lajara, Eda Cengiz, Robert J Tanenberg
BACKGROUND: Despite improvements in anti-hyperglycemic therapies, there are many unmet clinical needs that hinder successful glycemic control in people being treated with current basal insulin analogs. OBJECTIVE: This paper reviews the unmet needs associated with current basal insulin therapy and describes the most recent basal insulins for the treatment of diabetes. METHODS: PubMed was searched for articles on basal insulin analogs published between 2000 and April 2016...
February 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28274631/curcumolide-reduces-diabetic-retinal-vascular-leukostasis-and-leakage-partly-via-inhibition-of-the-p38mapk-nf-%C3%AE%C2%BA-b-signaling
#17
Yuan Cai, Wencan Li, Hongfeng Tu, Nanmei Chen, Zhipeng Zhong, Pengcheng Yan, Jianyong Dong
Retinal inflammation in a hyperglycemic condition is believed to play a crucial role in the development of diabetic retinopathy, and targeting inflammatory mediators is a promising strategy for the control of diabetic retinopathy. Curcumolide, a novel sesquiterpenoid with a unique 5/6/5 tricyclic skeleton, was isolated from Curcuma wenyujin. In this study, we demonstrate that treatment with curcumolide alleviated retinal inflammatory activities both in vitro and in vivo in a STZ-induced diabetic rat model and in TNF-α-stimulated HUVECs...
February 22, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28274349/sex-hormones-and-acne
#18
Qiang Ju, Tao Tao, Tingting Hu, Ayşe Serap Karadağ, Safaa Al-Khuzaei, WenChieh Chen
The skin is an endocrine organ with the expression of metabolizing enzymes and hormone receptors for diverse hormones. The sebaceous gland is the main site of hormone biosynthesis, especially for androgens, and acne is the classical androgen-mediated dermatosis. In sebocytes, conversion of 17-hydroxyprogesterone directly to dihydrotestosterone bypassing testosterone has been demonstrated, while type II 17β-hydroxysteroid dehydrogenase can inactivate the action of testosterone and dihydrotestosterone. The androgen receptor-dependent genomic effect of dihydrotestosterone on sebocytes is confirmed...
March 2017: Clinics in Dermatology
https://www.readbyqxmd.com/read/28271054/association-of-diabetes-mellitus-and-structural-changes-in-the-central-nervous-system-in-children-and-adolescents-a-systematic-review
#19
REVIEW
Ata Pourabbasi, Mehdi Tehrani-Doost, Soqra Ebrahimi Qavam, Seyed Masoud Arzaghi, Bagher Larijani
BACKGROUND: The relationship between diabetes and academic performance have been of great interest to researchers during the year to date. Many studies have been conducted to discover this relationship during three recent decades. But, evaluation of the structural changes of brain in the context of diabetes is of paramount importance especially in children and adolescents. METHODS: This study is a systematic review conducted to investigate the structural changes in the central nervous system in children and adolescents living with diabetes...
2017: Journal of Diabetes and Metabolic Disorders
https://www.readbyqxmd.com/read/28269596/non-linear-dynamic-modeling-of-glucose-in-type-1-diabetes-with-kernel-adaptive-filters
#20
Eleni I Georga, Jose C Principe, Demosthenes Polyzos, Dimitrios I Fotiadis
We propose a non-linear recursive solution to the problem of short-term prediction of glucose in type 1 diabetes. The Fixed Budget Quantized Kernel Least Mean Square (QKLMS-FB) algorithm is employed to construct a univariate model of subcutaneous glucose concentration, which: (i) handles nonlinearities by transforming the input space into a high-dimensional Reproducing Kernel Hilbert Space and, (ii) finds a sparse solution by retaining a representative subset of the training input vectors. The dataset comes from the continuous multi-day recordings of 15 type 1 patients in free-living conditions...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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