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https://www.readbyqxmd.com/read/28743043/neurotrophy-and-immunomodulation-of-induced-neural-stem-cell-grafts-in-a-mouse-model-of-closed-head-injury
#1
Mou Gao, Hui Yao, Qin Dong, Yan Zhang, Yang Yang, Yihua Zhang, Zhijun Yang, Minhui Xu, Ruxiang Xu
Closed head injury (CHI) usually results in severe and permanent neurological impairments, which are caused by several intertwined phenomena, such as cerebral edema, blood-brain barrier (BBB) disruption, neuronal loss, astroglial scarring and inflammation. We previously reported that induced neural stem cells (iNSCs), similar to neural stem cells (NSCs), can accelerate neurological recovery in vivo and produce neurotrophic factors in vitro. However, the effects of iNSC neurotrophy following CHI were not determined...
July 18, 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28742822/metal-ion-coordination-in-the-e-coli-nudix-hydrolase-dihydroneopterin-triphosphate-pyrophosphatase-new-clues-into-catalytic-mechanism
#2
Shannon E Hill, Elaine Nguyen, Chiamaka U Ukachukwu, Dana M Freeman, Stephen Quirk, Raquel L Lieberman
Dihydroneopterin triphosphate pyrophosphatase (DHNTPase), a member of the Mg2+ dependent Nudix hydrolase superfamily, is the recently-discovered enzyme that functions in the second step of the pterin branch of the folate biosynthetic pathway in E. coli. DHNTPase is of interest because inhibition of enzymes in bacterial folate biosynthetic pathways is a strategy for antibiotic development. We determined crystal structures of DHNTPase with and without activating, Mg2+-mimicking metals Co2+ and Ni2+. Four metal ions, identified by anomalous scattering, and stoichiometrically confirmed in solution by isothermal titration calorimetry, are held in place by Glu56 and Glu60 within the Nudix sequence motif, Glu117, waters, and a sulfate ion, of which the latter is further stabilized by a salt bridge with Lys7...
2017: PloS One
https://www.readbyqxmd.com/read/28742748/beyond-the-psa-test-how-to-better-stratify-a-patient-s-risk-of-prostate-cancer
#3
Ryan Lewis, Brad Hornberger
The primary method of screening for and detecting prostate cancer is the prostate-specific antigen (PSA) test. Although this test is very prostate-specific, it is not cancer-specific; conditions other than prostate cancer can cause an elevated PSA. Many efforts have been made to discover more specific tests and methods beyond the PSA. This article describes several literature-supported tests and methods to better stratify a man's risk of having prostate cancer.
August 2017: JAAPA: Official Journal of the American Academy of Physician Assistants
https://www.readbyqxmd.com/read/28742712/specialist-physicians-attitudes-and-practice-patterns-regarding-disclosure-of-pre-referral-medical-errors
#4
Lesly A Dossett, Rondi M Kauffmann, Jay S Lee, Harkamal Singh, M Catherine Lee, Arden M Morris, Reshma Jagsi, Gwendolyn P Quinn, Justin B Dimick
OBJECTIVE: Our objective was to determine specialist physicians' attitudes and practices regarding disclosure of pre-referral errors. SUMMARY BACKGROUND DATA: Physicians are encouraged to disclose their own errors to patients. However, no clear professional norms exist regarding disclosure when physicians discover errors in diagnosis or treatment that occurred at other institutions before referral. METHODS: We conducted semistructured interviews of cancer specialists from 2 National Cancer Institute-designated Cancer Centers...
July 24, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28742392/t-gowler-discovering-generalized-process-models-within-texts
#5
Ahmed Halioui, Petko Valtchev, Abdoulaye Baniré Diallo
Contemporary workflow management systems are driven by explicit process models specifying the interdependencies between tasks. Creating these models is a challenging and time-consuming task. Existing approaches to mining concrete workflows into models tackle design aspects related to the diverging abstraction levels of the tasks. Concrete workflow logs represent tasks and cases of concrete events-partially or totally ordered-grounding hidden multilevel (abstract) semantics and contexts. Relevant generalized events could be rediscovered within these processes...
August 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28742329/selecting-dna-encoded-chemical-library-against-non-immobilized-proteins-using-a-ligate-crosslink-purify-strategy
#6
Bingbing Shi, Yuqing Deng, Peng Zhao, Xiaoyu Li
DNA-encoded chemical library (DEL) has recently emerged and become an important technology platform in biomedical research and drug discovery. DELs containing large numbers of compounds can be prepared and selected against biological targets to discover novel ligands and inhibitors. In practice, DELs are usually selected against purified and immobilized proteins using the typical "bind-wash-elute" protocol; however, selection methods compatible with non-immobilized proteins would be able to greatly expand the target scope of DELs beyond purified proteins to more complex and biologically relevant targets...
July 25, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28742206/bioinformatics-analysis-of-rna-seq-data-revealed-critical-genes-in-colon-adenocarcinoma
#7
W-D Xi, Y-J Liu, X-B Sun, J Shan, L Yi, T-T Zhang
OBJECTIVE: RNA-seq data of colon adenocarcinoma (COAD) were analyzed with bioinformatics tools to discover critical genes in the disease. Relevant small molecule drugs, transcription factors (TFs) and microRNAs (miRNAs) were also investigated. MATERIALS AND METHODS: RNA-seq data of COAD were downloaded from The Cancer Genome Atlas (TCGA). Differential analysis was performed with package edgeR. False positive discovery (FDR) < 0.05 and |log2 (fold change)|>1 were set as the cut-offs to screen out differentially expressed genes (DEGs)...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28742151/exploring-the-cross-talk-between-er-stress-and-inflammation-in-age-related-macular-degeneration
#8
Samira Kheitan, Zarrin Minuchehr, Zahra-Soheila Soheili
Increasing evidence demonstrates that inflammation and endoplasmic reticulum (ER) stress is implicated in the development and progression of age-related macular degeneration (AMD), a multifactorial neurodegenerative disease. However the cross talk between these cellular mechanisms has not been clearly and fully understood. The present study investigates a possible intersection between ER stress and inflammation in AMD. In this study, we recruited two collections of involved protein markers to retrieve their interaction information from IMEx-curated databases, which are the most well- known protein-protein interaction collections, allowing us to design an intersection network for AMD that is unprecedented...
2017: PloS One
https://www.readbyqxmd.com/read/28742128/construction-and-characterization-of-the-korean-whole-saliva-proteome-to-determine-ethnic-differences-in-human-saliva-proteome
#9
Ha Ra Cho, Han Sol Kim, Jun Seo Park, Seung Cheol Park, Kwang Pyo Kim, Troy D Wood, Yong Seok Choi
As the first step to discover protein disease biomarkers from saliva, global analyses of the saliva proteome have been carried out since the early 2000s, and more than 3,000 proteins have been identified in human saliva. Recently, ethnic differences in the human plasma proteome have been reported, but such corresponding studies on human saliva in this aspect have not been previously reported. Thus, here, in order to determine ethnic differences in the human saliva proteome, a Korean whole saliva (WS) proteome catalogue indexing 480 proteins was built and characterized through nLC-Q-IMS-TOF analyses of WS samples collected from eleven healthy South Korean male adult volunteers for the first time...
2017: PloS One
https://www.readbyqxmd.com/read/28742072/phaeoviruses-discovered-in-kelp-laminariales
#10
Dean A McKeown, Kim Stevens, Akira F Peters, Peter Bond, Glenn M Harper, Colin Brownlee, Murray T Brown, Declan C Schroeder
Phaeoviruses are latent double-stranded DNA viruses that insert their genomes into those of their brown algal (Phaeophyceae) hosts. So far these viruses are known only from members of the Ectocarpales, which are small and short-lived macroalgae. Here we report molecular and morphological evidence for a new Phaeovirus cluster, referred to as sub-group C, infecting kelps (Laminariales) of the genera Laminaria and Saccharina, which are ecologically and commercially important seaweeds. Epifluorescence and TEM observations indicate that the Laminaria digitata Virus (LdigV), the type species of sub-group C, targets the host nucleus for its genome replication, followed by gradual degradation of the chloroplast and assembly of virions in the cytoplasm of both vegetative and reproductive cells...
July 25, 2017: ISME Journal
https://www.readbyqxmd.com/read/28741920/new-reliever-of-jaw-pain-discovered
#11
(no author information available yet)
No abstract text is available yet for this article.
September 2016: Journal—California Dental Association
https://www.readbyqxmd.com/read/28741876/discovery-of-novel-potent-muscarinic-m3-receptor-antagonists-with-proper-plasma-stability-by-structural-recombination-of-marketed-m3-antagonists
#12
Zuojuan Xiang, Jun Liu, Hongbin Sun, Xiaoan Wen
The marketed long-acting M3 antagonists for treatment of chronic obstructive pulmonary disease have inappropriate plasma stability (either overstable or excessively unstable), which causes substantial systemic exposure or poor patient compliance. To discover novel M3 antagonists with proper plasma stability, we synthesized and biologically evaluated a series of chiral quaternary ammonium salts of pyrrolidinol esters, which were designed by structural recombination of the marketed M3 antagonists. As a result, two novel potent M3 antagonists, (R/S)-3-[2-hydroxy-2,2-di(thiophen-2-yl)acetoxy]-1,1-dimethylpyrrolidinium bromides (1 a: Ki =0...
July 25, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28741662/molecular-breakdown-a-comprehensive-view-of-anaplastic-lymphoma-kinase-alk-rearranged-non-small-cell-lung-cancer
#13
Ka-Won Noh, Mi-Sook Lee, Seung Eun Lee, Ji-Young Song, Hyun-Tae Shin, Yu Jin Kim, Doo Yi Oh, Kyungsoo Jung, Minjung Sung, Mingi Kim, Sungbin An, Joungho Han, Young Mog Shim, Jae Ill Zo, Jhingook Kim, Woong-Yang Park, Se-Hoon Lee, Yoon-La Choi
Most anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancers (NSCLCs) show good clinical response to ALK inhibitors. However, some ALK-rearranged NSCLC patients show various primary responses with unknown reasons. Previous studies focused on the clinical aspects of ALK fusions in small cohorts, or were conducted in vitro and/or in vivo to investigate the function of ALK. One of the suggested theories describes how Echinoderm microtubule-associated protein-like 4 (EML4)-ALK variants play a role towards different sensitivities in ALK inhibitors...
July 25, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28741469/interlaboratory-comparison-for-the-determination-of-24-25-dihydroxyvitamin-d%C3%A2-in-human-serum-using-liquid-chromatography-with-tandem-mass-spectrometry
#14
Stephen Wise, Susan Tai, Michael Nelson, Carolyn Burdette, Johanna Camara, Andrew Hoofnagle, Thomas Laha, Graham Carter, Julia Jones, Emma Williams, Zoe Barclay, Glenville Jones, Martin Kaufmann, Neil Binkley, Amita Kapoor, Toni Ziegler, Kevin Cashman, Kirsten Dowling, Christopher Sempos
Six laboratories associated with the Vitamin D Standardization Program (VDSP) participated in an interlaboratory comparison of LC with tandem MS (MS/MS) methods for the determination of 24,25-dihydroxyvitamin D₃ [24,25(OH)₂D₃] in human serum. The laboratories analyzed two different serum-based Standard Reference Materials (SRMs) intended for use in the determination of 25-hydroxyvitamin D and 30 samples from the Vitamin D External Quality Assessment Scheme (DEQAS). All laboratory methods for 24,25(OH)₂D₃ were based on isotope dilution LC-MS/MS; three of the methods used derivatization of the vitamin D metabolites before LC-MS/MS...
July 24, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28741379/tiny-rnas-and-their-voyage-via-extracellular-vesicles-secretion-of-bacterial-small-rna-and-eukaryotic-microrna
#15
Ji-Woong Choi, Jee-Hyun Um, Jin-Hyun Cho, Heon-Jin Lee
MicroRNAs are small non-coding RNAs that bind to the 3'-untranslated region of target mRNAs and have transcriptional or translational inhibitory function in eukaryotes. Before microRNAs were widely known, bacterial non-coding small RNAs around 50-200 nt in length were discovered whose mechanism of action resembled that of microRNAs. Recently, RNAs that are of similar size to or smaller than microRNAs have been discovered in bacteria and indeed, this class of small RNAs have been found throughout all domains of life...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28741140/melt-extrusion-for-a-high-melting-point-compound-with-improved-solubility-and-sustained-release
#16
Jiannan Lu, Sakae Obara, Fei Liu, Wanyi Fu, Wen Zhang, Shingo Kikuchi
The objective of the current study was to develop an amorphous solid dispersion for a high melting point compound, griseofulvin (GRF), with an enhanced solubility and a controlled release pattern utilizing hot melt extrusion (HME) technology. Hypromellose acetate succinate (HPMCAS, Shin-Etsu AQOAT®, medium particle size) was explored as the polymeric carrier, while hypromellose (HPMC, Metolose® SR) was chosen as the release rate control agent. GRF presented an HPMCAS grade-dependent solubility: AS-HMP > AS-MMP > AS-LMP...
July 24, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28741074/concurrent-chemoradiotherapy-with-weekly-nedaplatin-versus-radiotherapy-alone-in-elderly-patients-with-non-small-cell-lung-cancer
#17
F Chen, P Hu, N Liang, J Xie, S Yu, T Tian, Jingxin Zhang, G Deng, Jiandong Zhang
PURPOSE: We conduct this study to compare the efficacy and toxicity of intensity-modulated radiotherapy (IMRT) concurrent weekly nedaplatin (NDP) versus IMRT alone in the stage III/IV non-surgical elderly patients with non-small-cell lung cancer (NSCLC). METHODS: 117 patients were enrolled into our study. The patients were assigned into two different groups: radiotherapy (RT) group and chemoradiotherapy (CRT) group. Patients in RT group were treated with IMRT at a single daily dose of 2 Gy for 5 days per week, totally 52-66 Gy...
July 24, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28740948/a-rare-case-of-spigelian-hernia-combined-with-direct-and-indirect-inguinal-hernias
#18
Murat Özgür Kılıç, Gürkan Değirmencioğlu, Cenap Dener
Spigelian hernia is a rare type of ventral hernias with nonspecific symptoms and signs. Therefore, its diagnosis is often difficult and requires more clinical attention. Although intermittent abdominal swelling and pain are the main symptoms, Spigelian hernias can be sometimes asymptomatic and are discovered incidentally at the operation. In some cases, these hernias can be associated with other abdominal wall hernias, therefore a detailed physical examination of the patients is necessary to avoid mistakes in diagnosis...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740631/increased-risk-of-coronary-perforation-during-percutaneous-intervention-of-myocardial-bridge-what-histopathology-says
#19
Somayeh Pourhoseini, Mohammad Bakhtiari, Abdolreza Babaee, Mohammad Ali Ostovan, Seyed Hassan Eftekhar-Vaghefi, Nikan Ostovan, Pooyan Dehghani
Introduction: Myocardial bridge (MB) is a segment of a major epicardial coronary artery that goes intramurally under a bridge of overlying myocardium. Complications have been reported during or after stent implantation particularly coronary perforation. The aim of this study was to determine histological differences between proximal left anterior descending artery (LAD) and the tunneled segment that may have a possible role in increased risk of coronary artery perforation during percutaneous coronary intervention...
2017: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/28740611/development-of-potent-myostatin-inhibitory-peptides-through-hydrophobic-residue-directed-structural-modification
#20
Kentaro Takayama, Cédric Rentier, Tomo Asari, Akari Nakamura, Yusuke Saga, Takahiro Shimada, Kei Nirasawa, Eri Sasaki, Kyohei Muguruma, Akihiro Taguchi, Atsuhiko Taniguchi, Yoichi Negishi, Yoshio Hayashi
Myostatin, a negative regulator of skeletal muscle growth, is a promising target for treating muscle atrophic disorders. Recently, we discovered a minimal myostatin inhibitor 1 (WRQNTRYSRIEAIKIQILSKLRL-amide) derived from positions 21-43 of the mouse myostatin prodomain. We previously identified key residues (N-terminal Trp(21), rodent-specific Tyr(27), and all aliphatic amino acids) required for effective inhibition through structure-activity relationship (SAR) studies based on 1 and characterized a 3-fold more potent inhibitor 2 bearing a 2-naphthyloxyacetyl group at position 21...
July 13, 2017: ACS Medicinal Chemistry Letters
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