Dong Cheng, Bradley A Zinker, Yi Luo, Petia Shipkova, Claudia H De Oliveira, Gopal Krishna, Elizabeth A Brown, Stephanie L Boehm, Giridhar S Tirucherai, Huidong Gu, Zhengping Ma, Ching-Hsuen Chu, Joelle M Onorato, Lisa M Kopcho, Ron Ammar, Julia Smith, Pratik Devasthale, R Michael Lawrence, Steven A Stryker, Elizabeth A Dierks, Anthony V Azzara, Leon Carayannopoulos, Edgar D Charles, Kimberley A Lentz, David A Gordon
Monoacylglycerol acyltransferase 2 (MGAT2) is an important enzyme highly expressed in the human small intestine and liver for the regulation of triglyceride absorption and homeostasis. We report that treatment with BMS-963272, a potent and selective MGAT2 inhibitor, decreased inflammation and fibrosis in CDAHFD and STAM, two murine nonalcoholic steatohepatitis (NASH) models. In high-fat-diet-treated cynomolgus monkeys, in contrast to a selective diacylglycerol acyltransferase 1 (DGAT1) inhibitor, BMS-963272 did not cause diarrhea...
November 1, 2022: Cell Metabolism