Kylie S Chichura, Clinton T Elfers, Therese S Salameh, Varun Kamat, Oleg G Chepurny, Aelish McGivney, Brandon T Milliken, George G Holz, Sarah V Applebey, Matthew R Hayes, Ian R Sweet, Christian L Roth, Robert P Doyle
Mechanisms underlying long-term sustained weight loss and glycemic normalization after obesity surgery include changes in gut hormone levels, including glucagon-like peptide 1 (GLP-1) and peptide YY (PYY). We demonstrate that two peptide biased agonists (GEP44 and GEP12) of the GLP-1, neuropeptide Y1, and neuropeptide Y2 receptors (GLP-1R, Y1-R, and Y2-R, respectively) elicit Y1-R antagonist-controlled, GLP-1R-dependent stimulation of insulin secretion in both rat and human pancreatic islets, thus revealing the counteracting effects of Y1-R and GLP-1R agonism...
June 12, 2023: Scientific Reports