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NSAID gastropathy

Sachin Manocha, Dushyant Lal, Subramanian Venkataraman
BACKGROUND: Nonsteroidal anti-inflammatory drugs induces gastric mucosal lesions because of its acidic properties. Ranitidine, an H2 receptor antagonist, has proved beneficial in patients with gastric ulcers. OBJECTIVE: The present study was performed to assess the effect of administering ranitidine in Nonsteroidal anti-inflammatory drugs (diclofenac, nimesulide) induced gastropathy, and their effect on the histopathology of stomach, kidney and liver. METHODS: Diclofenac, nimesulide, and ranitidine were administered in doses of 2, 4, and 6 mg/kg, p...
January 2016: Arquivos de Gastroenterologia
T E Morozova, S M Rykova, M A Chukina
The widespread use in clinical practice of non-steroidal anti-inflammatory drugs (NSAIDs), largely due to the general trend towards an aging population and, as a consequence, increase the number of individuals with comorbid conditions and diseases, including the most common are diseases of the cardiovascular system, diseases of the joints and spine, requiring of therapy with, combining the anti-inflammatory and analgesic properties. However, NSAIDs not only have favorable effects, but have quite a wide range of adverse effects, an important place among which is NSAID-induced gastropathy...
2015: Experimental & Clinical Gastroenterology
Devendra Pratap Singh, Swapnil P Borse, Manish Nivsarkar
INTRODUCTION: Progress in management of Nonsteroidal anti-inflammatory drug (NSAID) induced gastrointestinal toxicity requires the availability of appropriate experimental animal models that are as close to humans as feasible. Our objective was to develop a rat model for NSAID-induced gastroenteropathy and also to simulate the common clinical scenario of co-administration of NSAID and proton pump inhibitor (PPI) to explore if PPI contribute to exacerbation of NSAID-enteropathy. METHODS: Rats were treated twice daily with pantoprazole sodium (PTZ; 10mg/kg peroral) or vehicle for a total of 10days...
March 2016: Journal of Pharmacological and Toxicological Methods
S I Pimanov, E V Makarenko, E A Dikareva
AIM: To estimate the impact of adherence with proton pump inhibitor (PPI) therapy on the incidence of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy (NSAID gastropathy) in patients with rheumatoid arthritis (RA). SUBJECTS AND METHODS: PPI pharmacotherapy adherence was estimated using the Medication Adherence Questionnaire (MAQ) in 92 patients with RA, including 32 patients did not take a PPI and 60 used a PPI. The groups were matched for age, disease duration, and used NSAIDs...
2015: Terapevticheskiĭ Arkhiv
Krishnendu Sinha, Pritam Sadhukhan, Sukanya Saha, Pabitra Bikash Pal, Parames C Sil
BACKGROUND: Deregulation in prostaglandin (PG) biosynthesis, severe oxidative stress, inflammation and apoptosis contribute to the pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy. Unfortunately, most of the prescribed anti-ulcer drugs generate various side effects. In this scenario, we could consider morin as a safe herbal potential agent against IND-gastropathy and rationalize its action systematically. METHODS: Rats were pretreated with morin for 30 min followed by IND (48 mgkg(-1)) administration for 4 h...
April 2015: Biochimica et Biophysica Acta
Anita Gupta, Lu Zheng, Vendhan Ramanujam, John Gallagher
OBJECTIVE: To illustrate the potential value of pharmacogenetic testing to identify patients at risk for nonsteroidal anti-inflammatory drug-induced gastropathy. DESIGN: Case report. SETTING: We report a case encountered in an outpatient setting for pain management. PATIENT: We present a case of a patient treated with celecoxib who developed severe nonsteroidal anti-inflammatory drug-induced gastropathy. INTERVENTION: Suspecting a relation between this adverse event and altered drug metabolism, pharmacogenetic testing was performed to assess the role of the cytochrome P450 (CP450) enzyme profile...
May 2015: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
M Iu Zak
122 patients with osteoarthrosis, who have in the past medical history verified chronic gastritis (50 males and 72 females) at the age from 42 to 64 have been examined. Control group was comprised of 40 patients with osteoarthrosis without gastroduodenal zone pathology in the past medical history. For arthralgia relief patients were prescribed meloxicam (average dose--12.5 - 1.39 mg daily) or nimesulide (average dose--150 ± 14.91 mg daily). As a result of this research it was determined that administration of selective NSAID (meloxicam and nimesulide) in patients with chronic gastritis in the past medical history raised the risk of NSAID gastropathy/dyspepsia 2...
November 2014: Likars'ka Sprava
Carla J Gargallo, Carlos Sostres, Angel Lanas
Nonsteroidal anti-inflammatory drug (NSAID) treatment will be necessary as part of our therapeutic armamentarium for many years to come. Therefore, safe prescription is mandatory in order to prevent adverse events. In the last two decades, new strategies and new drugs have been developed to reduce NSAID-associated upper gastrointestinal (GI) adverse events. Although the implementation of guidelines into clinical practice takes time, several studies have shown a recent and profound decrease in hospitalizations due to upper GI complications, which has been linked to widespread use of proton pump inhibitors (PPIs), better NSAID prescription, and decreased prevalence of Helicobacter pylori infection...
December 2014: Current Treatment Options in Gastroenterology
Jeong Ho Kim, Soo-Heon Park, Chul-Soo Cho, Soo Teik Lee, Wan-Hee Yoo, Sung Kook Kim, Young Mo Kang, Jong Sun Rew, Yong-Wook Park, Soo Kon Lee, Yong Chan Lee, Won Park, Don-Haeng Lee
BACKGROUND/AIMS: The use of proton pump inhibitors or misoprostol is known to prevent the gastrointestinal complications of nonsteroidal anti-inflammatory drugs (NSAIDs). Rebamipide is known to increase the mucosal generation of prostaglandins and to eliminate free oxygen radicals, thus enhancing the protective function of the gastric mucosa. However, it is unknown whether rebamipide plays a role in preventing NSAID-induced gastropathy. The aim of this study was to determine the effectiveness of rebamipide compared to misoprostol in preventing NSAID-induced gastrointestinal complications in patients requiring continuous NSAID treatment...
July 2014: Gut and Liver
Sherif Mohamed Zaki, Enas Ahmed Mohamed
INTRODUCTION: Indomethacin is a non steroidal anti-inflammatory drug (NSAID) which is capable of producing injury to gastric mucosa. To prevent of NSAID-induced gastropathy, it is important to evaluate the risk factors. One of them is steroid. The aim is to study time dependent effects of glucocorticoids (GC) on indomethacin induced gastric ulcer. MATERIAL AND METHODS: Forty-nine albino rats were used. They were divided into control and experimental groups. The experimental group was subgroup I (rats were given indomethacin and were sacrificed 1 day after drug intake), subgroup II (rats were given indomethacin + dexamethasone and were sacrificed 1 day after drug intake), subgroup III (rats were given indomethacin + dexamethasone and were sacrificed 3 days after drug intake) and subgroup IV (rats were given indomethacin + dexamethasone and were sacrificed 7 days day after drug intake)...
May 12, 2014: Archives of Medical Science: AMS
Andrzej S Tarnawski, Amrita Ahluwalia, Michael K Jones
This review updates the current views on aging gastric mucosa and the mechanisms of its increased susceptibility to injury. Experimental and clinical studies indicate that gastric mucosa of aging individuals-"aging gastropathy"-has prominent structural and functional abnormalities vs young gastric mucosa. Some of these abnormalities include a partial atrophy of gastric glands, impaired mucosal defense (reduced bicarbonate and prostaglandin generation, decreased sensory innervation), increased susceptibility to injury by a variety of damaging agents such as ethanol, aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), impaired healing of injury and reduced therapeutic efficacy of ulcer-healing drugs...
April 28, 2014: World Journal of Gastroenterology: WJG
José Luis Marco, Pedro Amariles, Beatriz Boscá, Ana Castelló
UNLABELLED: Abstract. BACKGROUND: NSAIDs are a significant cause of drug-related hospital admissions and deaths. The therapeutic effects of NSAIDs have been associated with the risk for developing adverse events, mainly in the gastrointestinal tract. OBJECTIVES: The focus of this study was to identify the most common risk factors associated with NSAID-induced upper gastrointestinal bleeding (UGIB) resulting in hospital admissions. A secondary end point was the relationship between use of gastroprotective treatment and relevant risk factors to NSAID-induced UGIB in the selected population...
March 2007: Current Therapeutic Research, Clinical and Experimental
Sílvio Manfredo Vieira, Rangel Leal Silva, Henrique Paula Lemos, Rodrigo César das Neves Amorim, Ellen Cristina Costa Silva, Peter Sol Reinach, Fernando Queiróz Cunha, Adrian Martin Pohlit, Thiago Mattar Cunha
Infusions of Picrolemma sprucei roots, stems and leaves are used in traditional medicine throughout the Amazon region from the Guianas to Brazil and Peru in the treatment of gastritis, intestinal helminths and malaria. As there are no studies describing its mode of action in providing a gastroprotective effect, we determined herein that one of the main constituents found in P. sprucei infusions, the quassinoid isobrucein B (IsoB), reduces some of the pathophysiological effects in a mouse model of non-steroidal anti-inflammatory drug (NSAID)-induced gastritis and provides mechanisms of action...
June 2014: Fitoterapia
Michael C Auld, Benjamin R Dodd, Andrew P Barbour, Mark Smithers
No abstract text is available yet for this article.
July 2015: ANZ Journal of Surgery
Abd Elrazek M A Abd Elrazek, Hamdy M Mahfouz, Amro M Metwally, Ahmed M El-Shamy
BACKGROUND AND AIM: Patients with acute upper gastrointestinal (GI) bleeding commonly present with hematemesis and/or melena. More studies are needed to confirm the ability to predict mortality, length of stay, and cost. Alcohol abuse may worsen variceal bleeding or portal hypertensive gastropathy in a patient with a history of liver disease. Coexisting alcoholism may influence patient management in the setting of peptic ulceration or existing malignancy. Consequently, the overall morbidities and mortalities may differ in alcoholic and nonalcoholic groups accordingly...
February 2014: European Journal of Gastroenterology & Hepatology
Shivaram Prasad Singh, Manas Kumar Panigrahi
INTRODUCTION: Upper gastrointestinal bleeding (UGIB) is one of the commonest gastrointestinal emergencies encountered by physicians and surgeons. The spectrum of upper gastrointestinal bleeding varies from region to region and depends on the status of the center in healthcare hierarchy. AIM: To determine the etiology of UGIB at a gastroenterology clinic in coastal Orissa and to compare it with other regions of India. METHODS: Six hundred and eight consecutive patients with UGIB reporting to a gastroenterology outpatient clinic were subjected to upper gastrointestinal endoscopy (UGIE) to find out the etiology...
January 2013: Tropical Gastroenterology: Official Journal of the Digestive Diseases Foundation
Samik Bindu, Somnath Mazumder, Sumanta Dey, Chinmay Pal, Manish Goyal, Athar Alam, Mohd Shameel Iqbal, Souvik Sarkar, Asim Azhar Siddiqui, Chinmoy Banerjee, Uday Bandyopadhyay
Nonsteroidal anti-inflammatory drug (NSAID)-induced mitochondrial oxidative stress (MOS) is an important prostaglandin (PG)-independent pathway of the induction of gastric mucosal injury. However, the molecular mechanism behind MOS-mediated gastric pathology is still obscure. In various pathological conditions of tissue injury oxidative stress is often linked with inflammation. Here we report that MOS induced by indomethacin (an NSAID) induces gastric mucosal inflammation leading to proinflammatory damage. Indomethacin, time dependently stimulated the expression of proinflammatory molecules such as intercellular adhesion molecule 1(ICAM-1), vascular cell adhesion molecule 1(VCAM-1), interleukin1β (IL-1β), and monocyte chemotactic protein-1 (MCP-1) in gastric mucosa in parallel with the increase of neutrophil infiltration and injury of gastric mucosa in rat...
December 2013: Free Radical Biology & Medicine
Steven G Kinsey, Erica C Cole
Nonsteroidal anti-inflammatory drugs (NSAIDs), which are among the most widely used analgesics in the world, cause gastrointestinal inflammation that is potentially life-threatening. Although inhibitors of endocannabinoid catabolic enzymes protect against gastropathy in fasted NSAID-treated mice, the gastroprotective effects of Δ(9)-tetrahydrocannabinol (THC), the primary psychoactive component of marijuana, have yet to be investigated. Male C57BL/6J mice were fasted, administered vehicle or Δ(9)-THC (.01-50mg/kg; oral or intraperitoneal), and then treated with the NSAID diclofenac sodium (100mg/kg, p...
September 5, 2013: European Journal of Pharmacology
Mau Sinha, Lovely Gautam, Prakash Kumar Shukla, Punit Kaur, Sujata Sharma, Tej P Singh
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most highly prescribed drugs in the world. Their analgesic, anti-inflammatory, and antipyretic actions may be beneficial; however, they are associated with severe side effects including gastrointestinal injury and peptic ulceration. Though several approaches for limiting these side effects have been adopted, like the use of COX-2 specific drugs, comedication of acid suppressants like proton pump inhibitors and prostaglandin analogs, these alternatives have limitations in terms of efficacy and side effects...
2013: Mediators of Inflammation
Sudhir K Yadav, Biplab Adhikary, Sandip K Bandyopadhyay, Subrata Chattopadhyay
BACKGROUND: The gastro-intestinal disorders, induced by the NSAIDs including indomethacin (IND) remain unresolved medical problems. Herein, we disclose allylpyrocatechol (APC) as a potential agent against IND-gastropathy and rationalize its action mechanistically. METHODS: Mice were pre-treated with APC for 1h followed by IND (18mgkg(-1)) administration, and the ulcer-prevention capacity of APC was evaluated on the 3rd day by histology. Its effect on the inflammatory (MPO, cytokines, adhesion molecules), ulcer-healing (COX, prostaglandins, growth factors and their receptors) and signaling parameters (NF-κB and MAPKs) were assessed by immunoblots/mRNA, and ELISA at the time points of their maximal changes due to IND administration...
June 2013: Biochimica et Biophysica Acta
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