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Abdominal aortic aneurysm

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https://www.readbyqxmd.com/read/27914533/prophylactic-abdominal-aortic-aneurysm-repair-open-repair-brings-early-pain-but-later-gain
#1
EDITORIAL
J T Powell
No abstract text is available yet for this article.
December 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27914158/causes-of-death-in-an-acute-psychiatric-inpatient-unit-of-a-portuguese-general-hospital
#2
Sofia Barbosa, Márcia Sequeira, Sara Castro, Rita Manso, Catarina Klut Câmara, Bruno Trancas, Nuno Borja-Santos, Teresa Maia
INTRODUCTION: Psychiatric patients are at increased risk of death from a number of natural and unnatural causes. This study examines the mortality causes of all psychiatric inpatients of an acute psychiatric unit at a general hospital in Portugal for sixteen years (1998 to 2013). MATERIAL AND METHODS: Twenty-one inpatients died at the inpatient unit between 1998 and 2013 (average 1.3 per year). A retrospective study through case-file review was carried to collect demographic characteristics, medical and psychiatry diagnosis...
August 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27912196/nox-isoforms-in-the-development-of-abdominal-aortic-aneurysm
#3
Kin Lung Siu, Qiang Li, Yixuan Zhang, Jun Guo, Ji Youn Youn, Jie Du, Hua Cai
Oxidative stress plays an important role in the formation of abdominal aortic aneurysm (AAA), and we have recently established a causal role of uncoupled eNOS in this severe human disease. We have also shown that activation of NADPH oxidase (NOX) lies upstream of uncoupled eNOS. Therefore, identification of the specific NOX isoforms that are required for eNOS uncoupling and AAA formation would ultimately lead to novel therapies for AAA. In the present study, we used the Ang II infused hph-1 mice to examine the roles of NOX isoforms in the development of AAA...
November 19, 2016: Redox Biology
https://www.readbyqxmd.com/read/27910812/inflammatory-markers-associated-with-abdominal-aortic-aneurysm
#4
Sarah Lindberg, Moncef Zarrouk, Jan Holst, Anders Gottsäter
PURPOSE: Inflammation with leukocytic infiltration, degradation of extracellular matrix (ECM), and depletion of vascular smooth muscle cells (VSMC) are pathological hallmarks of abdominal aortic aneurysm (AAA). The aim of this study was to further evaluate relationships between AAA and inflammatory biomarkers, interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), endothelin-1 (ET-1) and soluble urokinase-type plasminogen activator receptor (suPAR), by comparing levels in 65-year-old men with and without AAA at ultrasound screening...
September 1, 2016: European Cytokine Network
https://www.readbyqxmd.com/read/27908891/the-paraoxonase-gene-cluster-protects-against-abdominal-aortic-aneurysm-formation
#5
Yun-Fei Yan, Jian-Fei Pei, Ran Zhang, Fang Wang, Peng Gao, Zhu-Qin Zhang, Ting-Ting Wang, Yang Zhang, Zhi-Gang She, Hou-Zao Chen, De-Pei Liu
OBJECTIVE: Abdominal aortic aneurysm (AAA) is a life-threatening vascular pathology, the pathogenesis of which is closely related to oxidative stress. However, an effective pharmaceutical treatment is lacking because the exact cause of AAA remains unknown. Here, we aimed at delineating the role of the paraoxonases (PONs) gene cluster (PC), which prevents atherosclerosis through the detoxification of oxidized substrates, in AAA formation. APPROACH AND RESULTS: PC transgenic (Tg) mice were crossed to an Apoe(-/-) background, and an angiotensin II-induced AAA mouse model was used to analyze the effect of the PC on AAA formation...
December 1, 2016: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/27908818/ascending-aorta-to-hepatic-and-mesenteric-artery-bypassing-in-patients-with-chronic-mesenteric-ischaemia-and-extensive-aortic-disease-a-case-report-and-review-of-the-literature
#6
James Barr, John Kokotsakis, Pantelis Tsipas, Prodromos Papapavlou, Konstantinos Velissarios, Theodoros Kratimenos, Thanos Athanasiou
Chronic mesenteric ischaemia (CMI) is a rare disorder caused by severe stenosis of the mesenteric arterial supply that results in post prandial pain and weight loss. Treatment options are surgical or endovascular. Surgical bypass can be performed in an antegrade fashion from the supracoeliac abdominal aorta or the distal descending thoracic aorta or in a retrograde fashion from the infra-renal aorta or the common iliac artery. However in some patients with disease of the descending thoracic aorta (DTA) or the abdominal aorta (AA) another site for the proximal anastomosis needs to be found...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27908817/clinical-outcome-after-endovascular-sealing-of-abdominal-aortic-aneurysms-evas-a-retrospective-cohort-study
#7
Maria Karouki, Charles Swaelens, Luigi Iazzolino, Richard G McWilliams, Robert K Fisher, Andrew England, Francesco Torella
PURPOSE: To present the clinical outcome of endovascular sealing of abdominal aortic aneurysms (EVAS) with the Nellix endoprosthesis in patients with abdominal aortic aneurysms treated in our institution. METHODS: This was a retrospective, single centre, observational cohort study. A departmental database was interrogated in order to extract demographics, clinical information and outcome of all patients treated with EVAS between December 2013 and December 2015. Outcome measures included technical success (successful device deployment and absence of any endoleak at completion angiography), mortality, major complications, incidence of endoleaks, aneurysm rupture and reintervention...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27908815/regional-variation-in-postoperative-myocardial-infarction-in-patients-undergoing-vascular-surgery-in-the-united-states
#8
Andrea M Steely, Peter W Callas, Daniel Neal, Salvatore T Scali, Philip P Goodney, Andres Schanzer, Jack L Cronenwett, Daniel J Bertges
OBJECTIVE: To assess for regional variation in the incidence of postoperative myocardial infarction (POMI) following non-emergent vascular surgery across the United States in order to identify potential areas for quality improvement initiatives. METHODS: We evaluated POMI rates across 17 regional Vascular Quality Initiative (VQI) groups comprised of 243 centers with 1,343 surgeons who performed 75,057 vascular operations from 2010-2014. Four procedures were included in the analysis: carotid endarterectomy (CEA, n=39,118), endovascular abdominal aortic aneurysm (AAA) repair (EVAR, n=15,106), infra-inguinal bypass (INFRA, n=17,176), and open infra-renal AAA repair (OAAA, n=3,657)...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27908811/decreased-serum-levels-of-high-mobility-group-box-1-hmgb-1-after-graft-replacement-or-stenting-of-abdominal-aortic-aneurysm
#9
Daiki Ousaka, Yasuhiro Fujii, Susumu Oozawa, Masahiro Nishibori, Yosuke Kuroko, Zenichi Masuda, Shunji Sano
OBJECTIVES: High-mobility group box 1 (HMGB-1) is a key substance mediating inflammation and development of atherosclerotic lesions (AL), including abdominal aortic aneurysms (AAA). Serum levels of HMGB-1 are increased in patients with AAA than in normal controls because the ALs in AAAs secrete HMGB-1. We therefore postulate that the serum HMGB-1 level should decrease after endovascular aortic repair (EVAR) or open aortic repair (OAR). However, there is no evidence of this in the literature...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27908810/emergent-treatment-of-a-ruptured-thoraco-abdominal-aortic-aneurysm-by-off-label-rescue-implantation-of-the-ovation-%C3%A2-stent-graft-in-nonagenarians-patient
#10
Chiara Pranteda, Pasqualino Sirignano, Federica Fornelli, Wassim Mansour, Nunzio Montelione, Laura Capoccia, Francesco Speziale
We report a case of a compassionate treatment of a ruptured thoraco-abdominal aortic aneurysm in a 92-year-old patient. Patient was admitted to our emergency department for acute onset of pain irradiating to the back. Computed tomographic angiography showed the presence of a thoraco-abdominal aortic aneurysm with a contained rupture at infrarenal level. Given of the presence of a relative healthy visceral aorta, we decided to treat the patient by Ovation(®) (Endologix, Irvine, CA - USA) implantation in an off-label fashion...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27908809/a-combination-of-thoracic-and-abdominal-grafts-to-treat-an-abdominal-aortic-aneurysm-with-hostile-proximal-neck
#11
Mafalda Massara, Roberto Prunella, Pasquale Gerardi, Giovanni De Caridi, Raffaele Serra, Stefano Notarstefano, Giovanni Impedovo
Endovascular aneurysm repair (EVAR) actually represents the treatment of choice for most patients affected by aneurysm of the abdominal aorta (AAA). However, the feasibility of EVAR depends on anatomical characteristics of abdominal aorta and ilio-femoral axis. We present the case of a 82-years old man affected by severe left hydronephrosis, kidney and ureteral tumor requiring nephrectomy, that presented also a very voluminous AAA with a large diameter (96 mm), presenting also with a large proximal neck (39 mm) and with a severe angulation of the proximal neck (> 60°)...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27908804/custom-made-conical-endograft-in-the-treatment-of-saccular-abdominal-aortic-aneurysms-with-tight-and-calcified-distal-neck-thinking-out-of-the-box
#12
Efstratios Georgakarakos, Christos Argyriou, Nikolaos Schoretsanitis, George S Georgiadis
PURPOSE: to describe the use of the combination of a conical custom-made TREO® (TREO CM) stent-graft in the treatment of a saccular abdominal aortic endograft (AAA) with long but tight and calcified distal neck. TECHNIQUE: A 65-year female patient was treated for a saccular 5.2 cm AAA with a 3cm-long but calcified and tight (16mm) distal neck, precluding the safe use of a bifurcated endograft. Since the patient refused an open surgery, a conical TREO CM endograft was manufactured with 20% proximal oversizing, whereas the 3cm caudal sealing segment demonstrated a conical configuration comprised of a 2cm and 1cm nitinol-supported zones of 20% and 10% oversizing, respectively, in order to avoid excessive strain and incomplete expand at the most distal calcified area, leading ultimately to an insidious infolding and consequent type Ib endoleak...
November 28, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27905693/revisiting-the-cost-effectiveness-of-screening-65-year-old-men-for-abdominal-aortic-aneurysm-based-on-data-from-an-implemented-screening-programme
#13
Jakob Hager, Martin Henriksson, Per Carlsson, Toste Länne, Fredrik Lundgren
BACKGROUND: Health economic analyses based on randomized trials have shown that screening for abdominal aortic aneurysm (AAA) cost-effectively decreases AAA-related, as well as all- cause mortality. However, follow-up from implemented screening programmes now reveal substantially changed conditions in terms of prevalence, attendance rate, costs and mortality after intervention. Our aim was to evaluate whether screening for AAA among 65-year-old men is cost-effective based on contemporary data on prevalence and attendance rates from an ongoing AAA screening programme...
December 1, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27905691/is-volume-important-in-aneurysm-treatment-outcome
#14
Athanasios Katsargyris, Chris Klonaris, Eric L Verhoeven
Several studies have suggested that surgical procedures performed at high-volume centers may result in superior outcome. Technically more demanding procedures such as aortic aneurysm repair appear to demonstrate a stronger relationship with volume. The present chapter reviewed the literature using the MEDLINE database to identify studies investigating the effect of volume in aortic aneurysm repair outcomes. The great majority of studies identified shows an advantage for high-volume hospitals with regard to perioperative mortality of abdominal (AAA), thoracic (TAA) and thoracoabdominal (TAAA) aortic aneurysm repair...
December 1, 2016: Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/27904852/analysis-of-in-hospital-mortality-and-long-term-survival-excluding-in-hospital-mortality-after-open-surgical-repair-of-ruptured-abdominal-aortic-aneurysm
#15
Jun Gyo Gwon, Tae-Won Kwon, Yong-Pil Cho, Young Jin Han, Min Su Noh
PURPOSE: The aim of this study was to confirm the factors that affect the mortality associated with the open surgical repair of ruptured abdominal aortic aneurysm (rAAA) and to analyze the long-term survival rates. METHODS: A retrospective review was performed on a prospectively collected database that included 455 consecutive patients who underwent open surgical repair for AAA between January 2001 and December 2012. We divided our analysis into in-hospital and postdischarge periods and analyzed the risk factors that affected the long-term survival of rAAA patients...
December 2016: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/27904826/infective-abdominal-aortitis-due-to-campylobacter-fetus-bacteremia-a-case-report-and-review-of-literature
#16
Abhinav Agrawal, Rutuja R Sikachi
Infectious aortitis (IA) is a rare but life-threatening condition, and most commonly affects the abdominal aorta or thoracic aorta. Various microorganisms have been associated with infectious thoracic aortitis, most commonly Staphylococcus, Enterococcus, Streptococcus, and Salmonella species. Campylobacter fetus (C. fetus) has been seen as a cause of infective aortitis only in a few case reports. We report a rare case of infective aortitis of the abdominal aorta caused due to C. fetus bacteremia. While C. fetus infections usually occur in patients with immunosuppression, such as malignancy, or those with diabetes mellitus, but our patient was not immunocompromised...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27904124/mycotic-aneurysm-caused-by-bacteroides-fragilis-in-an-elderly-immunosuppressed-patient
#17
Takahiko Fukuchi, Sadao Kawasaki, Hiroki Hayashi, Daisuke Koreeda, Takahiro Ashikawa
An 82-year-old Japanese man, who presented with a fever and abdominal pain, was admitted to our hospital. According to enhanced computed tomography images, the probable diagnosis was abdominal aortic mycotic aneurysm. Eight sets of blood cultures obtained from the patient were negative. Despite administering treatment with vancomycin and ceftriaxone, the aneurysm progressively enlarged. He underwent open debridement surgery and in situ replacement because of an aneurysmal rupture. Bacteroides fragilis was isolated from the tissue culture of the aortic wall...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27903785/microstructure-and-mechanics-of-healthy-and-aneurysmatic-abdominal-aortas-experimental-analysis-and-modelling
#18
Justyna A Niestrawska, Christian Viertler, Peter Regitnig, Tina U Cohnert, Gerhard Sommer, Gerhard A Holzapfel
Soft biological tissues such as aortic walls can be viewed as fibrous composites assembled by a ground matrix and embedded families of collagen fibres. Changes in the structural components of aortic walls such as the ground matrix and the embedded families of collagen fibres have been shown to play a significant role in the pathogenesis of aortic degeneration. Hence, there is a need to develop a deeper understanding of the microstructure and the related mechanics of aortic walls. In this study, tissue samples from 17 human abdominal aortas (AA) and from 11 abdominal aortic aneurysms (AAA) are systematically analysed and compared with respect to their structural and mechanical differences...
November 2016: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/27903534/high-structural-stress-and-presence-of-intraluminal-thrombus-predict-abdominal-aortic-aneurysm-18f-fdg-uptake-insights-from-biomechanics
#19
Yuan Huang, Zhongzhao Teng, Maysoon Elkhawad, Jason M Tarkin, Nikhil Joshi, Jonathan R Boyle, John R Buscombe, Timothy D Fryer, Yongxue Zhang, Ah Yeon Park, Ian B Wilkinson, David E Newby, Jonathan H Gillard, James H F Rudd
BACKGROUND: Abdominal aortic aneurysm (AAA) wall inflammation and mechanical structural stress may influence AAA expansion and lead to rupture. We hypothesized a positive correlation between structural stress and fluorine-18-labeled 2-deoxy-2-fluoro-d-glucose ((18)F-FDG) positron emission tomography-defined inflammation. We also explored the influence of computed tomography-derived aneurysm morphology and composition, including intraluminal thrombus, on both variables. METHODS AND RESULTS: Twenty-one patients (19 males) with AAAs below surgical threshold (AAA size was 4...
November 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27903485/endovascular-repair-of-thoraco-abdominal-aortic-aneurysm-in-high-surgical-risk-patients-fenestrated-and-branched-endografts
#20
E Gallitto, M Gargiulo, A Freyrie, C Bianchini Massoni, R Pini, C Mascoli, G L Faggioli, S Ancetti, A Stella
AIM: To report early and mid-term results of endovascular repair of thoraco-abdominal aneurysms (TAAA) by using of Cook-Zenith fenestrated/branched endografts (FB-EVAR) in high-surgical risk patients unfit for open repair (OR). METHODS: Between January 2012 and April 2015, all the patients with TAAA, considered at high-surgical risk for OR and treated by Cook-Zenith FB-EVAR, were prospectively enrolled. Patients were studied using a thoraco-abdominal computer tomography angiography (CTA) and dedicated software for advanced vessels analysis...
November 26, 2016: Annals of Vascular Surgery
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