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https://www.readbyqxmd.com/read/29251544/consensus-recommendations-for-managing-osteoarthritic-pain-with-topical-nsaids-in-asia-pacific
#1
Bonifacio S Rafanan, Benedict F Valdecañas, Boon Ping Lim, Anan Malairungsakul, Warat Tassanawipas, Chen Shiyi, Lung Fung Tse, Tuan Khanh Luong
Osteoarthritis prevalence is expected to increase markedly in the Asia-Pacific region due to rapid population aging. Identifying effective and safe therapeutic options to manage osteoarthritic pain is viewed as a priority. The Asia-Pacific Experts on Topical Analgesics Advisory Board developed consensus statements for use of topical NSAIDs in musculoskeletal pain. Evidence supporting these statements in osteoarthritic pain was reviewed. Best available evidence indicates that topical NSAIDs have a moderate effect on relief of osteoarthritic pain, comparable to that of oral NSAIDs but with a better risk-to-benefit ratio...
December 18, 2017: Pain Management
https://www.readbyqxmd.com/read/29227185/alternative-drug-delivery-for-patients-undergoing-cataract-surgery-as-demonstrated-in-a-canine-model
#2
L David Waterbury
PURPOSE: (1) To determine ketorolac concentrations in selected ocular tissues following the intracameral administration of phenylephrine and ketorolac injection 1%/0.3% (OMIDRIA®) delivered in irrigation solution during lens replacement surgery in beagle dogs. (2) To compare the ketorolac initial dose and resultant concentrations from the above study to those achieved in aqueous and vitreous by topical administration in patients undergoing cataract surgery or vitrectomy, respectively...
December 11, 2017: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29212381/lowering-side-effects-of-nsaid-usage-in-osteoarthritis-recent-attempts-at-minimizing-dosage
#3
Kevin H Maniar, Ian A Jones, Rayudu Gopalakrishna, C Thomas Vangsness
Osteoarthritis is a burdensome disease that causes progressive damage to articular cartilage. Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the preferred treatments for symptomatic relief. However, NSAIDs can cause serious dose-dependent side effects, which has prompted experts to recommend the minimization of NSAID dosage. Areas covered: This review focuses on three broad strategies that are currently being investigated or implemented to minimize NSAID dosage: nano-formulation, encapsulation, and topical delivery...
December 14, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/29182798/pharmacological-interventions-for-pain-relief-during-orthodontic-treatment
#4
REVIEW
Aoife B Monk, Jayne E Harrison, Helen V Worthington, Annabel Teague
BACKGROUND: Pain is a common side effect of orthodontic treatment. It increases in proportion to the amount of force applied to the teeth, and the type of orthodontic appliance used can affect the intensity of the pain. Pain during orthodontic treatment has been shown to be the most common reason for people wanting to discontinue treatment, and has been ranked as the worst aspect of treatment. Although pharmacological methods of pain relief have been investigated, there remains some uncertainty among orthodontists about which painkillers are most suitable and whether pre-emptive analgesia is beneficial...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29170308/11%C3%A2-topical-nsaids-for-analgesia-in-traumatic-corneal-abrasions-a-systematic-review-and-meta-analysis
#5
Annali Lawrenson, Abel Wakai
BACKGROUND: Traumatic corneal abrasions are common ocular presenTations in the ED. There is no consensus regarding the most appropriate analgesia for this condition. Topical non-steroidal anti-inflammatory drugs (NSAIDs) have been suggested as pain-relief to minimise systemic adverse events associated with oral analgesia. AIM: To identify and evaluate all randomised controlled trials (RCTs) comparing the use of topical NSAIDs with placebo or any alternative analgesic interventions in adults with traumatic corneal abrasions (including corneal abrasions arising from foreign body removal), to reduce pain, and its effects on healing time...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29104055/improving-the-direct-penetration-into-tissues-underneath-the-skin-with-iontophoresis-delivery-of-a-ketoprofen-cationic-prodrug
#6
Shabbir Lobo, Guang Yan
Current topical nonsteroidal anti-inflammatory drugs (NSAIDs) showed marginal efficacy in treatment of musculoskeletal disorders due to their fast clearance by skin blood flow and thus little direct penetration into the underlying muscle and joint tissues. Using ketoprofen (Kt) as a model NSAID and converting it to a cationic ester prodrug ketoprofen choline chloride (KCC), this study was to investigate the iontophoresis delivery of the prodrug KCC for improving the drug retention in the skin and the direct penetration into underlying tissues...
November 14, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29094878/topical-nsaids-for-chronic-musculoskeletal-pain-in-adults
#7
Joseph R Yancey, Catherine Gill
No abstract text is available yet for this article.
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29079568/comparative-risk-of-cardiovascular-outcomes-between-topical-and-oral-nonselective-nsaids-in-taiwanese-patients-with-rheumatoid-arthritis
#8
Tzu-Chieh Lin, Daniel H Solomon, Sara K Tedeschi, Kazuki Yoshida, Yea-Huei Kao Yang
BACKGROUND: Topical NSAIDs have less systemic absorption than oral NSAIDs. We examined the risk of cardiovascular events associated with nonselective topical NSAIDs versus oral NSAIDs among patients with rheumatoid arthritis in Taiwan. METHODS AND RESULTS: We conducted a retrospective cohort study that included patients with incident rheumatoid arthritis who were newly starting therapy with nonselective topical NSAIDs or oral NSAIDs. We used the Taiwan National Health Insurance Research Database (NHIRD)...
October 27, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29059585/cyclic-and-non-cyclic-breast-pain-a-systematic-review-on-pain-reduction-side-effects-and-quality-of-life-for-various-treatments
#9
REVIEW
Jan-Willem Groen, Sissi Grosfeld, Wichor M Bramer, Miranda F Ernst, Magriet M Mullender
CYCLIC AND NON-CYCLIC BREAST-PAIN: A systematic review on pain reduction, side effects, and quality of life for various treatments. BACKGROUND: No clear systematic-review on all the various treatment regimen for (Non-) cyclical-breast-pain currently exists. OBJECTIVES: The aim of this study was to assess the various forms of therapy for treatment of breast-pain and the evidence for their effectiveness. SEARCH STRATEGY: Search-terms included 'mastalgia' and 'therapy' or 'hormones' or 'nsaid' or 'psychotherapy' or 'analgesia' or 'surgery', and synonyms...
December 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29034454/successful-treatment-of-sapho-syndrome-with-apremilast
#10
S Adamo, J Nilsson, A Krebs, U Steiner, A Cozzio, L E French, A G A Kolios
Synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome is a rare disease with inflammatory osteoarticular and skin involvement. The pathogenesis of SAPHO syndrome remains unclear, but evidence suggests it may be an autoinflammatory disease triggered upon exposure to infectious agents in genetically predisposed individuals. Induction of the IL-23/Th17 axis as well as neutrophil activation seem to play a key role, and therapies targeting these immunological pathways, including TNF-inhibitors, ustekinumab, secukinumab and the IL-1 inhibitor anakinra are potential treatment options that need further investigation...
October 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29022772/formulation-and-delivery-strategies-of-ibuprofen-challenges-and-opportunities
#11
Jake Irvine, Afrina Afrose, Nazrul Islam
Ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) is mostly administered orally and topically to relieve acute pain and fever. Due to its mode of action this drug may be useful in the treatment regimens of other, more chronic conditions, like cystic fibrosis. This drug is poorly soluble in aqueous media and thus the rate of dissolution from the currently available solid dosage forms is limited. This leads to poor bioavailability at high doses after oral administration, thereby increasing the risk of unwanted adverse effects...
October 12, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28985220/combinatorial-treatment-with-topical-nsaids-and-anti-vegf-for-age-related-macular-degeneration-a-meta-analysis
#12
Songshan Li, Andina Hu, Wei Wang, Xiaoyan Ding, Lin Lu
Inflammation is a key pathogenic factor in age-related macular degeneration (AMD). However, the clinical importance of combining anti-VEGF agents and topical NSAIDs to reduce inflammation remains unclear. In this study, we systematically reviewed clinical trials comparing combined treatment versus anti-VEGF alone in AMD patients. We quantified treatment effects via meta-analysis. The pooled weighted mean difference (WMD, -0.91, 95%CI: -1.39 to -0.42, P = 0.0003) demonstrates that combined treatment may reduce required anti-VEGF injection number, probably by means of decreasing central retina thickness (CRT) (WMD = -22...
2017: PloS One
https://www.readbyqxmd.com/read/28983850/topical-administration-of-ibuprofen-for-injured-athletes-considerations-formulations-and-comparison-to-oral-delivery
#13
REVIEW
Martin Anthony Christopher Manoukian, Christopher William Migdal, Amode Ravindra Tembhekar, Jerad Alexander Harris, Charles DeMesa
Non-steroidal anti-inflammatory drugs (NSAIDs) are a class of drugs commonly used to treat both the acute and chronic injuries sustained by athletes during training and competition. In many parts of the world, NSAIDs can be purchased over-the-counter and used without any physician oversight. However, the chronic nature of overuse injuries requires NSAIDs to be taken orally for an extended period of time. As a result, they can have significant adverse effects on athletes, namely gastrointestinal (GI), renal, and cardiovascular damage...
October 5, 2017: Sports Medicine—Open
https://www.readbyqxmd.com/read/28983756/effects-of-photobiomodulation-therapy-and-topical-non-steroidal-anti-inflammatory-drug-on-skeletal-muscle-injury-induced-by-contusion-in-rats-part-1-morphological-and-functional-aspects
#14
Shaiane Silva Tomazoni, Lúcio Frigo, Tereza Cristina Dos Reis Ferreira, Heliodora Leão Casalechi, Simone Teixeira, Patrícia de Almeida, Marcelo Nicolas Muscara, Rodrigo Labat Marcos, Andrey Jorge Serra, Paulo de Tarso Camillo de Carvalho, Ernesto Cesar Pinto Leal-Junior
Musculoskeletal injuries are very frequent and are responsible for causing pain and impairment of muscle function, as well as significant functional limitations. In the acute phase, the most prescribed treatment is with non-steroidal anti-inflammatory drugs (NSAIDs), despite their questionable effectiveness. However, the use of photobiomodulation therapy (PBMT) in musculoskeletal disorders has been increasing in the last few years, and this therapy appears to be an interesting alternative to the traditional drugs...
December 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28942137/protective-effect-of-oleane-12-en-3%C3%AE-ol-28-oic-acid-3%C3%AE-d-glucopyranoside-in-ethanol-induced-gastric-ulcer-by-enhancing-the-prostaglandin-e2-level
#15
Imran Kazmi, Shakir Saleem, Tanveer Ahmad, Muhammad Afzal, Fahad A Al-Abbasi, Vikas Kumar, Firoz Anwar
ETHNOPHARMACOLOGICAL RELEVANCE: Lantana camara is a popular invasive weed utilized in the management of ulcer in different part of world. Study of specific compound present in this plant responsible for their antulcer activity is main topic of concern. Current study designed for evaluation of the antiulcer activity of oleane-12-en-3β-ol-28-oic acid 3β-D-glucopyranoside (OAG) from Lantana camara L. MATERIALS AND METHODS: Antiulcer activity was carried out on NSAID's (Aspirin) and ethanol induced ulcer model...
September 21, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28914687/prevention-of-macular-edema-after-cataract-surgery
#16
REVIEW
Laura H P Wielders, Jan S A G Schouten, Rudy M M A Nuijts
PURPOSE OF REVIEW: Although cataract surgery can effectively restore visual function in many patients with cataract, PCME remains an important cause of suboptimal visual acuity. The present review provides an overview of the current literature on the prevention and treatment of PCME. RECENT FINDINGS: Optimal prevention of PCME starts preoperatively with a personalized risk assessment. Diabetes mellitus, retinal vein occlusion, epiretinal membrane, macular hole, and uveitis are the most important risk factors for developing cystoid macular edema after cataract surgery...
January 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28913997/additive-effect-of-oral-steroid-with-topical-nonsteroidal-anti-inflammatory-drug-for-preventing-cystoid-macular-edema-after-cataract-surgery-in-patients-with-epiretinal-membrane
#17
COMPARATIVE STUDY
Seonghwan Kim, Mee Kum Kim, Won Ryang Wee
PURPOSE: To investigate the additive effect of oral steroid with topical nonsteroidal anti-inflammatory drug (NSAID) on cystoid macular edema (CME) in patients with epiretinal membrane (ERM) after cataract surgery. METHODS: Medical records of subjects who underwent uneventful cataract surgery (n = 1,349) were retrospectively reviewed; among these patients, those with pre-existing ERM (n = 81) were included. Patients were divided into two groups: one group had postoperative administration of oral steroid for 1 week (n = 45) and the other group did not have oral steroid administration (n = 36)...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28895213/supramolecular-synthon-approach-in-developing-anti-inflammatory-topical-gels-for-in%C3%A2-vivo-self-delivery
#18
Rajdip Roy, Parthasarathi Dastidar
A new series of tertiary-butyl ammonium (TBA) salts of various nonsteroidal anti-inflammatory drugs (NSAIDs) have been synthesized and characterized. Nearly 90 % of the NSAID-derived primary ammonium monocarboxylate (PAM) salts displayed remarkable gelation ability with various solvents including methyl salicylate. Single crystal X-ray diffraction data (SXRD) revealed the existence of 1D PAM synthon in the gelator salts. Structure-property correlation studies based on SXRD and powder X-ray diffraction (PXRD) data established the presence of the 1D PAM synthon in the bulk salts as well as in the corresponding xerogels...
September 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28884078/effects-of-topical-flurbiprofen-sodium-diclofenac-sodium-ketorolac-tromethamine-and-benzalkonium-chloride-on-corneal-sensitivity-in-normal-dogs
#19
Raquel de Araújo Cantarella, Juliana Kravetz de Oliveira, Daniel M Dorbandt, Fabiano Montiani-Ferreira
To evaluate corneal sensitivity by using the Cochet-Bonnet® esthesiometer in normal canine eyes at different time points following instillation of three different topical non-steroidal anti-inflammatory drugs (flurbiprofen sodium 0.03%, diclofenac sodium 0.1% and ketorolac tromethamine 0.5%) and benzalkonium chloride 0.01%. Six healthy mixed breed dogs from the same litter were used in two different stages. First, one drop of flurbiprofen sodium 0.03% and diclofenac sodium 0.1% in each eye; second, one drop of ketorolac tromethamine 0...
2017: Open Veterinary Journal
https://www.readbyqxmd.com/read/28819932/twice-daily-vs-once-daily-dosing-with-0-075-bromfenac-in-durasite-outcomes-from-a-14-day-phase-2-study
#20
William Trattler, Kamran Hosseini
INTRODUCTION: Bromfenac is a well-known topical ophthalmic nonsteroidal anti-inflammatory drug (NSAID) that is commercialized in the USA and other regions of the world. A new formulation, 0.075% bromfenac in DuraSite®, was developed to treat postoperative inflammation and reduce pain in patients who have undergone cataract surgery. We hypothesized that efficacy and safety would be enhanced with twice-daily (BID) dosing compared to once-daily (QD) dosing. METHODS: This was a multicenter, double-masked, comparative study in which 40 and 45 subjects were randomized to groups receiving BID dosing and QD dosing, respectively...
December 2017: Ophthalmology and Therapy
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