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Terpenoid

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https://www.readbyqxmd.com/read/29149812/architectures-and-mechanical-properties-of-drugs-and-complexes-of-surface-active-compounds-at-air-water-and-oil-water-interfaces
#1
Dipak K Sarker
BACKGROUND: Drugs can represents a multitude of compounds from proteins and peptides, such as growth hormones and insulin and on to simple organic molecules such as flurbiprofen, ibuprofen and lidocaine. Given the chemical nature of these compounds two features are always present. A portion or portions of the molecule that has little affinity for apolar surfaces and media and the opposite a series of part or one large part that has considerable affinity for hydrophilic, polar or charged media and surfaces...
November 17, 2017: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29146338/analysis-of-changes-in-volatile-constituents-and-expression-of-genes-involved-in-terpenoid-metabolism-in-oleocellosis-peel
#2
Jiao Xie, Lili Deng, Yahan Zhou, Shixiang Yao, Kaifang Zeng
Oleocellosis is a serious physiological disorder in citrus fruit that mainly results in appearance and quality deterioration. It has been well established that the occurrence of oleocellosis is highly correlated with the release of peel oil from citrus fruit, while there is little information on the dynamic changes in the content of the volatile constituents and the expression of genes involved in terpenoid metabolism during oleocellosis development. In the present research, large changes in the volatile profiles and gene expression in terpenoid metabolism were observed in oleocellosis peels compared to healthy ones...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29143351/apoptotic-and-antiproliferative-properties-of-3%C3%AE-hydroxy-%C3%AE-5-steroidal-congeners-from-a-partially-purified-column-fraction-of-dendronephthya-gigantea-against-hl-60-and-mcf-7-cancer-cells
#3
I P Shanura Fernando, K K Asanka Sanjeewa, Hyun-Soo Kim, Lei Wang, Won Woo Lee, You-Jin Jeon
Organisms belonging to the genus Dendronephthya are among a group of marine invertebrates that produce a variety of terpenoids with biofunctional properties. Many of these terpenoids have been proven effective as anticancer drugs. Here, we report the antiproliferative effect of 3β-hydroxy-Δ5-steroidal congeners against the proliferation of HL-60 human leukemia cells and MCF-7 human breast cancer cells. The sterol-rich fraction (DGEHF2-1) inhibited the growth of HL-60 and MCF-7 cells with IC50 values of 13...
November 16, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29143256/toxic-effects-of-solanum-xanthocarpum-sch-wendle-against-helicoverpa-armigera-hub-culex-quinquefasciatus-say-and-eisenia-fetida-savigny-1826
#4
Kathirvelu Baskar, Jeevanantham Ananthi, Savarimuthu Ignacimuthu
Many commercially available agro and household chemicals are used as pesticides, repellents, and growth inhibitors against insect pests. The repeated uses of these chemicals against insect pests have caused the development of resistance in them; they also cause ill effects on nontarget organisms. The present study was aimed to evaluate the antifeedant, larvicidal, pupicidal, and biochemical effects of the solvent extracts of Solanum xanthocarpum against third instar larvae of Helicoverpa armigera. Hexane, chloroform and ethyl acetate extracts were subjected to phytochemical analysis...
November 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29142432/inhibition-of-glycation-induced-cytotoxicity-protein-glycation-and-activity-of-proteolytic-enzymes-by-extract-from-perovskia-atriplicifolia-roots
#5
Mehran Miroliaei, Akram Aminjafari, Sylwester Ślusarczyk, Izabela Nawrot-Hadzik, Mehdi Rahimmalek, Adam Matkowski
Background: Protein glycation and glycotoxicity belong to the main oxidative-stress related complications in diabetes. Perovskia species are used in Asian folk medicine as antidiabetic herbs. Objective: The aim of this study was to verify the ability of the methanolic extract from Perovskia atriplicifolia Benth. roots to diminish glycation of albumin and to prevent cell damage in vitro. Furthermore, we tested the extract for in vitro antioxidant activity and inhibition of elastase and collagenase...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29142389/bioactive-constituents-radical-scavenging-and-antibacterial-properties-of-the-leaves-and-stem-essential-oils-from-peperomia-pellucida-l-kunth
#6
Sunday O Okoh, Benson C Iweriebor, Omobola O Okoh, Anthony I Okoh
Background: Peperomia pellucida is an annual herbaceous ethnomedicinal plant used in the treatment of a variety of communicable and noncommunicable diseases in the Amazon region. Objective: The study aimed at profiling the bioactive constituents of the leaves and stem essential oils (LEO and SEO) of P. pellucida, their in vitro antibacterial and radical scavenging properties as probable lead constituents in the management of oxidative stress and infectious diseases...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141544/recent-updates-on-the-phytochemistry-pharmacological-and-toxicological-activities-of-zingiber-zerumbet-l-roscoe-ex-sm
#7
Md Areeful Haque, Ibrahim Jantan
BACKGROUND: Zingiber zerumbet (L.) Roscoe ex Sm. (family, Zingiberaceae) is a potent medicinal herb widely known as shampoo ginger and its rhizome is used in numerous ethnomedicinal applications including as antipyretic, anti-inflammatory, antibacterial, anti-diarrheal, antidiabetics, carminative, and diuretic. AIM: The aim of this review was to bring together all of scientific updates on the phytochemistry and pharmacological activities of this herb, including their toxicological studies, and critically analyzed the outcomes to provide directions for future research on the herb as potential source of bioactive metabolites for pharmaceutical and nutraceutical applications...
November 14, 2017: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/29139264/-construction-of-cell-factories-for-high-production-of-nerolidol-in-saccharomyces-cerevisiae
#8
Li-Li Zhang, Xiao-Lin Ma, Dong Wang, Peng Yu, Lu-Qi Huang, Xue-Li Zhang, Zhu-Bo Dai
Nerolidol is an important constituent of terpenoid essential oil and has excellent anti-tumor, anti-bacterial, and anti-oxidative properties. For realizing heterogenous production of nerolidol, our research firstly integrated the codon-optimized Actinidia sinensis nerolidol synthase gene (NES) into the terpenoid chassis strain FPP-001, and obtained NES-001 that could produce 2.71 mg•L⁻¹ nerolidol. Then, the N-terminal of the NES was fused with FPS by linker peptide GGGS. With this strategy, nerolidol production improved by 59...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29139263/-next-generation-sequencing-and-transcriptome-analysis-of-root-bark-from-paeonia-suffruticosa-cv-feng-dan
#9
Dong-Mei Xie, Nian-Jun Yu, Lu-Qi Huang, Dai-Yin Peng, Cong-Bin Liu, Yue-Jian Zhu, Hao Huang
Moutan Cortex is an important traditional Chinese medicine, "Fengdan Pi" was known as Dao-di herbs from the root bark of Paeonia suffruticosa cv. Feng Dan for its extracted various active components. However, the genetic basis for their activity is virtually unknown. The transcriptome of the root bark from "Fengdan" was sequenced using the Illumina HiSeq 4000 sequencing platform. The clean reads were then de novo assembled into 72 997 unigenes. Among them, the number of unigenes which could been annotated by dataset Nr and GO was 41 139 and 34 592...
August 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29137206/ancient-food-habits-dictate-that-food-can-be-medicine-but-medicine-cannot-be-food
#10
Hit Kishore Goswami, Hitendra Kumar Ram
Background: Extensive surveys of several population settlements in different parts of India-covering plains, mountains, valleys, river banks and deeper areas of forests at different altitudes-between 1968 and 2016 demonstrated that the basic vital need of hunger is being fulfilled since antiquity by plants in the wild. Methods: Based on collections, consultations with local population personnel and literature searches, this paper presents many plants that are commonly used as food and focuses on their products, which are rich in alkaloids, polysaccharides, steroids, terpenoids, flavonoids, aminoacids, fatty acids and antibiotics etc...
November 13, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29136886/determination-of-terpenoid-contents-of-aromatic-plants-using-nirs
#11
Elif Ercioglu, Hasan Murat Velioglu, Ismail Hakki Boyaci
The method was developed in order to provide a fast, simple and non-destructive analysis of terpenoid compounds of aromatic plants. For this purpose, spectroscopic data were collected on the surface of dried plant samples by using near infrared spectroscopic (NIRS) analysis. Volatile substances were extracted from aromatic plants using hydro-distillation method to determine terpenoid composition by using gas chromatography-mass spectrometry (GC-MS). Multivariate calibration methods namely, partial least squares (PLS) regression, were used for data analysis...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29132375/comparative-transcriptome-analysis-of-soybean-response-to-bean-pyralid-larvae
#12
Weiying Zeng, Zudong Sun, Zhaoyan Cai, Huaizhu Chen, Zhenguang Lai, Shouzhen Yang, Xiangmin Tang
BACKGROUND: Soybean is one of most important oilseed crop worldwide, however, its production is often limited by many insect pests. Bean pyralid is one of the major soybean leaf-feeding insects in China. To explore the defense mechanisms of soybean resistance to bean pyralid, the comparative transcriptome sequencing was completed between the leaves infested with bean pyralid larvae and no worm of soybean (Gantai-2-2 and Wan82-178) on the Illumina HiSeq™ 2000 platform. RESULTS: In total, we identified 1744 differentially expressed genes (DEGs) in the leaves of Gantai-2-2 (1064) and Wan82-178 (680) fed by bean pyralid for 48 h, compared to 0 h...
November 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29132306/rna-seq-analysis-of-resistant-and-susceptible-sub-tropical-maize-lines-reveals-a-role-for-kauralexins-in-resistance-to-grey-leaf-spot-disease-caused-by-cercospora-zeina
#13
Jacqueline Meyer, Dave K Berger, Shawn A Christensen, Shane L Murray
BACKGROUND: Cercospora zeina is a foliar pathogen responsible for maize grey leaf spot in southern Africa that negatively impacts maize production. Plants use a variety of chemical and structural mechanisms to defend themselves against invading pathogens such as C. zeina, including the production of secondary metabolites with antimicrobial properties. In maize, a variety of biotic and abiotic stressors induce the accumulation of the terpenoid phytoalexins, zealexins and kauralexins. RESULTS: C...
November 13, 2017: BMC Plant Biology
https://www.readbyqxmd.com/read/29126713/turmeric-curcuma-longa-mirnas-and-their-regulating-targets-are-involved-in-development-and-secondary-metabolite-pathways
#14
Noopur Singh, Ashok Sharma
Turmeric has been used as a therapeutic herb over centuries in traditional medicinal systems due to the presence of several secondary metabolite compounds. microRNAs are known to regulate gene expression at the post-transcriptional level by transcriptional cleavage or translation repression. miRNAs have been demonstrated to play an active role in secondary metabolism regulation. The present work was focused on the identification of the miRNAs involved in the regulation of secondary metabolite and development process of turmeric...
November 7, 2017: Comptes Rendus Biologies
https://www.readbyqxmd.com/read/29125569/rapid-determination-of-major-compounds-in-the-ethanol-extract-of-geopropolis-from-malaysian-stingless-bees-heterotrigona-itama-by-uhplc-q-tof-ms-and-nmr
#15
Lingling Zhao, Mengjiao Yu, Minghui Sun, Xiaofeng Xue, Tongtong Wang, Wei Cao, Liping Sun
A reliable, rapid analytical method was established for the characterization of constituents of the ethanol extract of geopropolis (EEGP) produced by Malaysian stingless bees-Heterotrigona itama-by combining ultra-high-performance liquid chromatography with quadruple time-of-flight mass spectrometry (UHPLC-Q-TOF/MS). Based on known standards, the online METLIN database, and published literature, 28 compounds were confirmed. Phenolic acids, flavones, triterpenes and phytosterol were identified or tentatively identified using characteristic diagnostic fragment ions...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29125568/chemical-composition-of-herbal-macerates-and-corresponding-commercial-essential-oils-and-their-effect-on-bacteria-escherichia-coli
#16
Marietta Białoń, Teresa Krzyśko-Łupicka, Agnieszka Pik, Piotr P Wieczorek
This study addresses the chemical composition of some commercial essential oils (clove, juniper, oregano, and marjoram oils), as well as appropriate herbal extracts obtained in the process of cold maceration and their biological activity against selected Escherichia coli strains: E. coli ATTC 25922, E. coli ATTC 10536, and E. coli 127 isolated from poultry waste. On the basis of the gas chromatography-mass spectrometry (GCMS) analysis, it was found that the commercial essential oils revealed considerable differences in terms of the composition and diversity of terpenes, terpenoids and sesquiterpenes as compared with the extracts obtained from plant material...
November 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29125010/the-genus-scrophularia-a-source-of-iridoids-and-terpenoids-with-a-diverse-biological-activity
#17
Ardalan Pasdaran, Azadeh Hamedi
CONTEXT: Scrophularia genus (Scrophulariaceae) includes about 350 species commonly known as figwort. Many species of this genus grow wild in nature and have not been cultivated yet. However, some species are in danger of extinction. OBJECTIVE: This paper reviews the chemical compounds, biological activities and the ethnopharmacology of some Scrophularia species. MATERIALS AND METHODS: All information was obtained through reported data on bibliographic database such as Scopus, United States National Agricultural Library, Biological Abstracts, EMBASE, PubMed, MedlinePlus, PubChem and Springer Link (1934-2017)...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29122483/new-terpenoids-and-thiophene-derivatives-from-the-aerial-parts-of-artemisia-sieversiana
#18
Xu-Dong Zhou, Chen Zhang, Shan He, Bin Zheng, Ke-Wu Zeng, Ming-Bo Zhao, Yong Jiang, Peng-Fei Tu
One new highly oxygenated nortriterpene, named sieverlactone (1), one new sesquiterpene, 1β,10β-epoxy-8α-acetoxyachillin (2), one new natural product, 5-propinyl-thiophene-2-carboxylic acid (3), and one new thiophene, 3-hydroxy-5-propinyl-2-acetyl-thiophene (4), together with 10 other known compounds (5-14), were isolated from the dried aerial parts of Artemisia sieversiana. Their structures were elucidated by a combination of extensive spectroscopic analysis, including 1D, 2D NMR spectroscopic and mass spectrometric data...
November 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29117577/diterpenoids-from-croton-crassifolius-include-a-novel-skeleton-possibly-generated-via-an-intramolecular-2-2-photocycloaddition-reaction
#19
Maosong Qiu, Jing Jin, Lian Zhou, Wen Zhou, Yinxiang Liu, Qinglong Tan, Di Cao, Zhongxiang Zhao
Five previously undescribed terpenoids (cracrosons D-H), including three clerodane diterpenoids, together with 16 known diterpenoids were isolated from Croton crassifolius (Euphorbiaceae). Cracroson D features a previously undescribed carbon skeleton with an unprecedented cyclobutane ring. Their structures, including their absolute configurations, were elucidated using spectroscopic and single-crystal X-ray diffraction analyses along with CD calculations. A plausible biogenetic pathway for cracroson D is also proposed, which was supported by the experimental results...
November 5, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29112983/identification-of-viscum-album-l-mirnas-and-prediction-of-their-medicinal-values
#20
Wenyan Xie, Jacob Adolf, Matthias F Melzig
MicroRNAs (miRNAs) are a class of approximately 22 nucleotides single-stranded non-coding RNA molecules that play crucial roles in gene expression. It has been reported that the plant miRNAs might enter mammalian bloodstream and have a functional role in human metabolism, indicating that miRNAs might be one of the hidden bioactive ingredients in medicinal plants. Viscum album L. (Loranthaceae, European mistletoe) has been widely used for the treatment of cancer and cardiovascular diseases, but its functional compounds have not been well characterized...
2017: PloS One
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