keyword
https://read.qxmd.com/read/38492997/a-molecular-typing-method-for-invasive-breast-cancer-by-serum-raman-spectroscopy
#1
JOURNAL ARTICLE
Jun Jiang, Lintao Li, Gang Yin, Huaichao Luo, Junjie Li
BACKGROUND: The incidence of breast cancer ranks highest among cancers and is exceedingly heterogeneous. Immunohistochemical staining is commonly used clinically to identify the molecular subtype for subsequent treatment and prognosis. PURPOSE: Raman spectroscopy and support vector machine (SVM) learning algorithm were utilized to identify blood samples from breast cancer patients in order to investigate a novel molecular typing approach. METHOD: Tumor tissue coarse needle aspiration biopsy samples, and peripheral venous blood samples were gathered from 459 invasive breast cancer patients admitted to the breast department of Sichuan Cancer Hospital between June 2021 and September 2022...
February 16, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38492995/comparison-of-pd-l1-22c3-expression-in-paired-primary-and-metastatic-breast-carcinoma
#2
JOURNAL ARTICLE
Xiao Huang, Sarah A Anderson, Gene P Siegal, Shi Wei, Shanrun Liu, Jingyun Yang, Puentes Roisin, J Taylor Pickens, Lei Huo, Aysegul A Sahin, Carlos Prieto Granada, Shuojun Chen
INTRODUCTION: PD-L1 immunohistochemistry (IHC) is being used as a predictive marker of the benefit derived from immunotherapy in several cancer types, including breast cancer. However, the insight gleaned of the prognostic and predictive value of PD-L1 status and its correlation with molecular characteristics during breast cancer progression remains limited. METHODS: We performed an PD-L1 (22C3) assay in pre-treatment primary and metastatic tumor sections from 33 patients with breast carcinoma, matched for post neoadjuvant chemotherapy (p-NACT)...
February 16, 2024: Clinical Breast Cancer
https://read.qxmd.com/read/38492534/comprehensive-analysis-of-transcription-factor-based-molecular-subtypes-and-their-correlation-to-clinical-outcomes-in-small-cell-lung-cancer
#3
JOURNAL ARTICLE
Sehhoon Park, Tae Hee Hong, Soohyun Hwang, Simon Heeke, Carl M Gay, Jiyeon Kim, Hyun-Ae Jung, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Jong Ho Cho, Yong Soo Choi, Jhingook Kim, Young Mog Shim, Hong Kwan Kim, Lauren Averett Byers, John V Heymach, Yoon-La Choi, Se-Hoon Lee, Keunchil Park
BACKGROUND: Recent studies have reported the predictive and prognostic value of novel transcriptional factor-based molecular subtypes in small-cell lung cancer (SCLC). We conducted an in-depth analysis pairing multi-omics data with immunohistochemistry (IHC) to elucidate the underlying characteristics associated with differences in clinical outcomes between subtypes. METHODS: IHC (n = 252), target exome sequencing (n = 422), and whole transcriptome sequencing (WTS, n = 189) data generated from 427 patients (86...
March 15, 2024: EBioMedicine
https://read.qxmd.com/read/38492371/ultrasmall-ru-nanoparticles-decorated-nickel-nickel-oxide-three-phase-heterojunctions-to-boost-alkaline-hydrogen-evolution
#4
JOURNAL ARTICLE
Na Xu, Jing-Yi Lv, Hai-Yi Sun, Xin-Jie Tian, Wen-Li Yu, Xin Li, Chun-Ying Liu, Yong-Ming Chai, Bin Dong
The rational design and optimization of heterogeneous interface for low loading noble metal HER eletrocatalysts to facilitate the upscaling of alkaline water/seawater electrolysis is highly challenging. Herein, we present a facile deep corrosion strategy induced by NaBH4 to precisely construct an ultrasmall Ru nanoparticle-decorated Ni/NiO hybrid (r-Ru-Ni/NiO) with highly dispersed triple-phase heterostructures. Remarkably, it exhibits superior activity with only 53 mV and 70 mV at 100 mA cm-2 for hydrogen evolution reaction (HER) in alkaline water and seawater, respectively, surpassing the performance of Pt/C (109...
February 29, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38492276/platinum-chemotherapy-for-early-triple-negative-breast-cancer
#5
REVIEW
Sofia Re Mason, Melina L Willson, Sam J Egger, Jane Beith, Rachel F Dear, Annabel Goodwin
BACKGROUND: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer associated with shorter survival and a higher likelihood of recurrence. In early TNBC, platinum chemotherapy has been shown to improve pathological complete response (pCR); however, its effect on long-term survival outcomes has not been fully elucidated. METHODS: Randomised controlled trials examining neoadjuvant or adjuvant platinum chemotherapy for early TNBC were included...
March 12, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38491681/active-crystallization-from-power-functional-theory
#6
JOURNAL ARTICLE
Sophie Hermann, Matthias Schmidt
We address the gas, liquid, and crystal phase behaviors of active Brownian particles in three dimensions. The nonequilibrium force balance at coexistence leads to equality of state functions for which we use power functional approximations. Motility-induced phase separation starts at a critical point and quickly becomes metastable against active freezing for Péclet numbers above a nonequilibrium triple point. The mean swim speed acts as a state variable, similar to the density of depletion agents in colloidal demixing...
February 2024: Physical Review. E
https://read.qxmd.com/read/38491581/synchronization-modes-of-triple-flickering-buoyant-diffusion-flames-experimental-identification-and-model-interpretation
#7
JOURNAL ARTICLE
Yicheng Chi, Zeying Hu, Tao Yang, Peng Zhang
The synchronization modes of a nonlinear oscillator system consisting of three identical flickering buoyant diffusion flames in isosceles triangles were studied experimentally and theoretically. Five synchronization modes, such as the in-phase, flickering death, partially flickering death, partially in-phase, and rotation modes, were experimentally observed and identified by systematically adjusting the flame distance and fuel flow rates. Two toy models were adopted to interpret the experimentally identified dynamical modes: one is the classical Kuramoto model, and the other is a complexified Stuart-Landau model, which was proposed through the introduction of the complex coupling term...
February 2024: Physical Review. E
https://read.qxmd.com/read/38490978/dual-inhibitors-of-dnmt-and-hdac-induce-viral-mimicry-to-induce-antitumour-immunity-in-breast-cancer
#8
JOURNAL ARTICLE
Wenjun Huang, Qingyun Zhu, Zhichao Shi, Yao Tu, Qinyuan Li, Wenwen Zheng, Zigao Yuan, Lulu Li, Xuyu Zu, Yue Hao, Bizhu Chu, Yuyang Jiang
The existing conventional treatments for breast cancer, including immune checkpoint blockade, exhibit limited effects in some cancers, particularly triple-negative breast cancer. Epigenetic alterations, specifically DNMT and HDAC alterations, are implicated in breast cancer pathogenesis. We demonstrated that DNMTs and HDACs are overexpressed and positively correlated in breast cancer. The combination of DNMT and HDAC inhibitors has shown synergistic antitumour effects, and our previously designed dual DNMT and HDAC inhibitor (termed DNMT/HDACi) 15a potently inhibits breast cancer cell proliferation, migration, and invasion and induces apoptosis in vitro and in vivo...
March 15, 2024: Cell Death Discovery
https://read.qxmd.com/read/38490875/effectiveness-analysis-of-three-drug-combination-therapies-for-refractory-focal-epilepsy
#9
JOURNAL ARTICLE
Chunmei Wu, Huiting Wu, Yingying Zhou, Xiaoyan Liu, Shanshan Huang, Suiqiang Zhu
Selecting appropriate antiseizure medications (ASMs) for combination therapy in patients with drug-resistant epilepsy (DRE) is a complex task that requires an empirical approach, especially in patients receiving polytherapy. We aimed to analyze the effectiveness of various three-drug combinations in a group of patients with DRE under real-world conditions. This single-center, longitudinal observational study investigated patients with drug-resistant focal epilepsy who received three-drug regimens in the outpatient clinic of Tongji Hospital from September 2019 to December 2022...
March 14, 2024: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://read.qxmd.com/read/38490483/zirconium-containing-nanoscale-coordination-polymers-for-positron-emission-tomography-and-fluorescence-guided-cargo-delivery-to-triple-negative-breast-tumors
#10
JOURNAL ARTICLE
Yan-Ping Li, Zi-Wen Pan, Yan-Jun Jiang, Ya-Yun Peng, Ting Cai, Hao Hong, Xiao-Feng Wang
Nanoscale coordination polymer (NCP) is a class of hybrid materials formed by self-assembly of metal ions and organic ligands through coordination. The applications of NCP in biomedicine are quite extensive due to the diversity choice of metal ions and organic ligands. Here we designed Zr-P1 NCP based on Zr4+ selected as metal ion nodes and tetrakis(4-carboxyphenyl) ethylene as bridging ligands. Zr-P1 NCP was modified with functionalized pyrene derived polyethylene glycol (Py-PAA-PEG-Mal) on the surface and further conjugated with cRGD for active targeting of integrin αv β3 overexpressed in triple-negative breast cancer...
March 13, 2024: Acta Biomaterialia
https://read.qxmd.com/read/38490330/directed-functional-connectivity-changes-of-triple-networks-for-stable-and-progressive-mild-cognitive-impairment
#11
JOURNAL ARTICLE
Darui Zheng, Yiming Ruan, Xuan Cao, Wenxuan Guo, Xulian Zhang, Wenzhang Qi, Qianqian Yuan, Xuhong Liang, Da Zhang, Qingling Huang, Chen Xue
Mild cognitive impairment includes two distinct subtypes, namely progressive mild cognitive impairment and stable mild cognitive impairment. While alterations in extensive functional connectivity have been observed in both subtypes, limited attention has been given to directed functional connectivity. A triple network, composed of the central executive network, default mode network, and salience network, is considered to be the core cognitive network. We evaluated the alterations in directed functional connectivity within and between the triple network in progressive and stable mild cognitive impairment groups and investigated its role in predicting disease conversion...
March 13, 2024: Neuroscience
https://read.qxmd.com/read/38490033/facile-al-2-o-3-coating-suppress-dissolution-of-mn-2-in-mn-substituted-na-3-v-2-po-4-3-with-outstanding-electrochemical-performance-for-full-sodium-ion-batteries
#12
JOURNAL ARTICLE
Chenghao Qian, Mengna Shi, Chunfang Fan, Changcheng Liu, Que Huang, Yanjun Chen
Na3 V2 (PO4 )3 (NVP) encounters significant obstacles, including limited intrinsic electronic and ionic conductivities, which hinder its potential for commercial feasibility. Currently, the substitution of V3+ with Mn2+ is proposed to introduce favorable carriers, enhancing the electronic conductivity of the NVP system while providing structural support and stabilizing the NASICON framework. This substitution also widens the Na+ migration pathways, accelerating ion transport. Furthermore, to bolster stability, Al2 O3 coating is applied to suppress the dissolution of transition metal Mn in the electrolyte...
March 12, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38490023/ultrasensitive-protein-and-exosome-analysis-based-on-a-rolling-circle-amplification-assisted-crispr-cas12a-strategy
#13
JOURNAL ARTICLE
Jingjing Shi, Chao Lei, Wenjiao Fan, Yuanyuan Sun, Chenghui Liu
CRISPR/Cas12a system has attracted extensive concern in biosensing due to its high specificity and programmability. Nevertheless, existing Cas12a-based assays mainly focus on nucleic acid detection and have limitations in non-nucleic acid biomarker analysis. To broaden the application prospect of the CRISPR/Cas technology, a cascade Cas12a biosensing platform is reported by combining dual-functionalized gold nanoparticles (FGNPs)-assisted rolling circle amplification (RCA) and Cas12a trans-cleavage activity (GAR-Cas) for ultrasensitive protein and exosome analysis...
March 11, 2024: Talanta
https://read.qxmd.com/read/38489960/plasma-metabolomics-identifies-s-adenosylmethionine-as-a-biomarker-and-potential-therapeutic-target-for-vascular-aging-in-older-adult-males
#14
JOURNAL ARTICLE
Zhenghui Gu, Yujia Wang, Zhiyi Fang, Tianhu Wang, Shan Gao, Qian Yang, Yingjie Zhang, Yabin Wang, Linghuan Wang, Li Fan, Feng Cao
Brachial-ankle pulse wave velocity (baPWV) is a noninvasive index of vascular aging. However, the metabolic profile underlying vascular aging has not yet been fully elucidated. The current study aimed to identify circulating markers of vascular aging as assessed by baPWV and to elucidate its mechanism from a metabolomic perspective in older adults. A total of 60 and 61 Chinese male participants aged ≥80 years were recruited to the metabolome and validation cohorts, respectively. The baPWV of participants was measured using an automatic waveform analyzer...
March 12, 2024: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/38489939/a-quantitative-lc-ms-ms-analysis-of-xylazine-p-fluorofentanyl-fentanyl-and-fentanyl-related-compounds-in-postmortem-blood
#15
JOURNAL ARTICLE
Michael T Truver, Sara C Brogan, Emma A Jaeschke, Amy M Kinsey, Jennifer L Hoyer, Chris W Chronister, Michele M Crosby, Bruce A Goldberger
The purpose of this study was to develop and validate a method to quantitate the veterinary sedative xylazine as well as 4-anilino-N-phenethylpiperidine (4-ANPP), acetyl fentanyl, fentanyl, norfentanyl, and p-fluorofentanyl in blood utilizing liquid chromatography tandem mass spectrometry. This method also qualitatively monitors for the presence of o-fluorofentanyl and m-fluorofentanyl isomers. UCT Clean Screen® DAU extraction columns were utilized to isolate the analytes in postmortem blood samples. The extracts were eluted, evaporated, reconstituted, and then analyzed using a Waters Acquity™ UPLC coupled a triple quadrupole mass spectrometer...
February 28, 2024: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://read.qxmd.com/read/38489756/asymmetric-deoxygenative-functionalization-of-secondary-amides-with-vinylpyridines-enabled-by-a-triple-iridium-photoredox-chiral-phosphoric-acid-system
#16
JOURNAL ARTICLE
Xiyike Deng, Feng Jiang, Xiaoming Wang
An enantioselective deoxygenative functionalization of secondary amides with vinylpridines is developed by merging relay iridium catalysis and cooperative photoredox-chiral Brønsted acid catalysis, affording a series of valuable chiral amines in moderate to good yields with good enantioselectivities. The intriguing multiple catalytic system invoking triple-catalysis was found to be the key to the success of the current reactions, which may stimulate further development of catalytic methodologies for asymmetric deoxygenative transformations of amides...
March 15, 2024: Organic Letters
https://read.qxmd.com/read/38489339/-daddy-comforts-me-young-swedish-children-s-perspectives-on-their-family-relations-before-and-after-their-parents-participation-in-a-parenting-programme
#17
JOURNAL ARTICLE
Anton Dahlberg, Karin Fängström
Despite extensive research assessing parenting support, there is a lack of knowledge about the perspectives of the youngest children. In this study, we explored changes in preschool children's emotional and relational experiences at home before and after their parents participated in a parenting intervention, the Triple P parenting programme. Nine children in total were interviewed, aged 3-6 years, whose parents participated in a group parenting intervention. The interviews were conducted during the first and final group sessions attended by the children's parents...
2024: PloS One
https://read.qxmd.com/read/38489292/the-n-linked-glycosylation-modifications-in-the-hepatitis-b-surface-protein-impact-cellular-autophagy-hbv-replication-and-hbv-secretion
#18
JOURNAL ARTICLE
Patcharin Tepjanta, Kazuhito Fujiyama, Ryo Misaki, Ingorn Kimkong
N-linked glycosylation is a pivotal post-translational modification that significantly influences various aspects of protein biology. Autophagy, a critical cellular process, is instrumental in cell survival and maintenance. The hepatitis B virus (HBV) has evolved mechanisms to manipulate this process to ensure its survival within host cells. Significantly, post-translational N-linked glycosylation in the large surface protein of HBV (LHBs) influences virion assembly, infectivity, and immune evasion. This study investigated the role of N-linked glycosylation of LHBs in autophagy, and its subsequent effects on HBV replication and secretion...
2024: PloS One
https://read.qxmd.com/read/38489159/triple-quadrupole-liquid-chromatography-mass-spectrometry-mediated-evaluation-of-vitamin-d-2-accumulation-potential-antioxidant-capacities-and-total-polyphenol-content-of-white-jelly-mushroom-tremella-fuciformis-berk
#19
JOURNAL ARTICLE
Marium Begum, Ratul Saikia, Siddhartha Proteem Saikia
Tremella fuciformis Berk. ( TF ), or the white jelly mushroom, is well known for its myriad of pharmacological properties, such as immunomodulatory, anti-inflammatory, antidiabetic, antitumor, and antioxidant activities, and hypocholesterolemic and hepatoprotective effects that boost human health. Most of the studies of TF are concentrated on its polysaccharide (glucuronoxylomannan) composition, which is responsible for its pharmacological as well as rheological properties. It is well established that mushrooms are a great source of dietary vitamin D due to the presence of ergosterol in their cell membrane...
March 15, 2024: Mycologia
https://read.qxmd.com/read/38488434/improving-therapeutic-potential-in-breast-cancer-via-histone-deacetylase-inhibitor-loaded-nanofibrils
#20
JOURNAL ARTICLE
Praveetha Senthilkumar, Bhaskar Gogoi, Swati Smita Dhan, Ramesh Subramani, Charumathi Pushparaj, Ayyavu Mahesh
Epigenetic modifications play a significant role in cancer progression, making them potential targets for therapy. Histone deacetylase inhibitors have shown promise in inhibiting cancer cell growth, including in breast cancer (BC). In this research, we examined the potential of using suberoyl anilide hydroxamic acid (SAHA)-loaded β-lg nanofibrils as a drug delivery system for triple-negative BC cell lines. We assessed their impact on cell cycle progression, apoptosis, levels of reactive oxygen species, and mitochondrial membrane potential in cancer cells...
April 2024: Drug Development Research
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