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Uveitis in Ankylosing Spondylitis

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https://www.readbyqxmd.com/read/28607176/clinical-features-of-hla-b27-positive-acute-anterior-uveitis-with-or-without-ankylosing-spondylitis-in-a-chinese-cohort
#1
Peizeng Yang, Wenjuan Wan, Liping Du, Qingyun Zhou, Jian Qi, Liang Liang, Chaokui Wang, Lili Wu, Aize Kijlstra
AIMS: To characterise the clinical features of human leucocyte antigen (HLA)-B27(+)acute anterior uveitis (AAU) patients with or without ankylosing spondylitis (AS) and investigate the retinal vascular involvement in these patients. METHODS: A total of 1056 HLA-B27(+) AAU patients (1525 eyes) were retrospectively studied from April 2008 to February 2016. Patients were divided into human leucocyte antigen (HLA)-B27(+)AS(+) and HLA-B27(+)AS(-) group. Clinical features including the onset of uveitis, laterality, the age at first attack, clinical examinations, best corrected visual acuity (BCVA), abnormalities in fundus fluorescence angiography (FFA) and complications were determined and compared between these two groups...
June 12, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28596287/incidence-and-prevalence-of-uveitis-in-south-korea-a-nationwide-cohort-study
#2
Tyler Hyungtaek Rim, Sung Soo Kim, Don-Il Ham, Seung-Young Yu, Eun Jee Chung, Sung Chul Lee
AIM: To evaluate the incidence and prevalence of uveitis and associated risk factors in South Korea. METHODS: For this retrospective national cohort study, approximately 1 000 000 Korean residents were randomly selected from the Korean National Health Insurance Service database. Uveitis was defined according to the Korean Classification of Diseases. The uveitis incidence and prevalence were calculated. Sociodemographic factors and comorbidities associated with uveitis were evaluated via Cox proportional regression models...
June 8, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28569222/is-the-current-asas-expert-definition-of-a-positive-family-history-useful-in-identifying-axial-spondyloarthritis-results-from-the-space-and-desir-cohorts
#3
Zineb Ez-Zaitouni, Andrea Hilkens, Laure Gossec, Inger Jorid Berg, Robert Landewé, Roberta Ramonda, Maxime Dougados, Désirée van der Heijde, Floris van Gaalen
BACKGROUND: The Assessment of SpondyloArthritis international Society (ASAS) definition of a positive family history (PFH) of spondyloarthritis (SpA) includes the following diseases in first- or second-degree relatives: ankylosing spondylitis (AS), acute anterior uveitis (AAU), reactive arthritis (ReA), inflammatory bowel disease (IBD), and psoriasis. However, it is not known if a PFH for each of these diseases contributes to making a diagnosis of axSpA, sacroiliitis on imaging, or fulfilling the ASAS criteria in patients presenting with chronic back pain (CBP)...
May 31, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28550390/clinical-patterns-and-characteristics-of-ankylosing-spondylitis-in-china
#4
Qiaoxia Qian, Xia Xu, Hongjun He, Hengdong Ji, Hui Zhang, Yue Ding, Sheng-Ming Dai, Yaohong Zou, Qi Zhu, Chengde Yang, Shuang Ye, Lindi Jiang, Jian-Ping Tang, Qiang Tong, Dongyi He, Dongbao Zhao, Yuan Li, Yanyun Ma, Jingru Zhou, Ziyu Yuan, Juan Zhang, Li Jin, Xiaodong Zhou, John D Reveille, Hejian Zou, Jiucun Wang
The study aimed to determine whether unique clinical patterns of AS may exist in China, specifically to explore the different clinical manifestations caused by gender, HLA-B27 status, and age at disease onset. The multicenter cross-sectional survey was conducted and 1251 patients were enrolled across China, representing a broad spectrum of Chinese AS patients. The mean age at onset and diagnosis were 29.2 (11.4) and 33.5 (12.6) years, respectively. The male/female ratio was 2.7:1. Acute anterior uveitis (AAU) was experienced in 10...
May 27, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28539676/results-from-polish-spondyloarthritis-initiative-registry-polspi-methodology-and-data-from-the-first-year-of-observation
#5
Zofia Guła, Tacjana Barczyńska, Marek Brzosko, Jerzy Gąsowski, Sławomir Jeka, Katarzyna Jodłowska-Cicio, Beata Kwaśny-Krochin, Piotr Leszczyński, Łukasz Lubiński, Katarzyna Łosińska, Katarzyna Pawlak-Buś, Hanna Przepiera-Będzak, Włodzimierz Samborski, Małgorzata Schlabs, Maciej Siedlar, Dorota Sikorska, Jerzy Świerkot, Małgorzata Węgierska, Piotr Wiland, Mariusz Korkosz
OBJECTIVES: Report on one-year results from the Polish Spondyloarthritis Initiative registry (PolSPI), containing the cross-sectional analysis of clinical and imaging data as well as database methodology. MATERIAL AND METHODS: The PolSPI registry includes patients with axial (axSpA) and peripheral (perSpA) spondyloarthritis according to ASAS classification criteria, and/or patients with ankylosing spondylitis according to modified New York criteria, psoriatic arthritis according to CASPAR criteria, arthropathy in inflammatory bowel disease, reactive arthritis, juvenile spondyloarthritis or undifferentiated spondyloarthritis...
2017: Reumatologia
https://www.readbyqxmd.com/read/28526894/association-of-hla-b27-with-ankylosing-spondylitis-and-clinical-features-of-the-hla-b27-associated-ankylosing-spondylitis-a-meta-analysis
#6
Hai Lin, Yi-Zhen Gong
Many studies have estimated the correlation between HLA-B27 polymorphisms and ankylosing spondylitis (AS). However, the results were controversial. Therefore, we performed this meta-analysis to determine the association of HLA-B*27 polymorphisms with AS and investigate the impacts of HLA-B27 on the clinical symptoms of AS patients. A comprehensive search was performed in PubMed, Web of Science and Embase databases to retrieve the eligible studies, which addressed the association between HLA-B27 polymorphisms and AS susceptibility...
May 19, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28520640/twenty-four-month-follow-up-of-tocilizumab-therapy-for-refractory-uveitis-related-macular-edema
#7
Marina Mesquida, Blanca Molins, Victor Llorenç, María V Hernández, Gerard Espinosa, Maite Sainz de la Maza, Alfredo Adán
BACKGROUND: To report the 24-month efficacy and safety of the interleukin-6 receptor antagonist tocilizumab (TCZ) for refractory uveitis-related macular edema (ME). METHODS: Data were obtained by standardized chart review. Patients with quiescent uveitis seen at a single tertiary referral center, for whom ME was the principal cause of reduced visual acuity. OUTCOME MEASURES: Central foveal thickness measured by optical coherence tomography; degree of anterior and posterior chamber; inflammation (Standardization of Uveitis Nomenclature Working Group criteria); and visual acuity (Snellen and logarithm of the minimum angle of resolution) were recorded in all patients during TCZ therapy at months 1, 3, 6, 12, 18, and 24...
May 16, 2017: Retina
https://www.readbyqxmd.com/read/28489625/the-disease-of-the-italian-poet-giacomo-leopardi-1798-1837-a-case-of-juvenile-ankylosing-spondylitis-in-the-19th-century
#8
Erik Pietro Sganzerla, Michele Augusto Riva
Some authors sustained that the pessimistic thought of the Italian writer and philosopher Giacomo Leopardi (1798-1837) may be attributed to his unhappy life, characterized by several health problems. His philosophical theories appear as the result of depressive and melancholic state, related to his precarious health conditions, so limiting their intrinsic values. Several authors formulated various hypotheses on the diseases that Leopardi suffered from and postulated different theories on the cause of his early death...
June 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28485181/higher-risk-of-incident-ankylosing-spondylitis-in-patients-with-uveitis-a-secondary-cohort-analysis-of-a-nationwide-population-based-health-claims-database
#9
M-C Lu, B-B Hsu, M Koo, N-S Lai
OBJECTIVES: Ankylosing spondylitis (AS) is a progressive, systemic, inflammatory autoimmune disease that typically affects young adults. Uveitis is a common extra-articular manifestation of AS. Nevertheless, the magnitude of the risk of AS among patients with uveitis is not clear. The aim of this secondary retrospective cohort study was to investigate the risk of incident AS in patients with uveitis using data from a nationwide, population-based health claims research database. METHOD: Using Taiwan's National Health Insurance Research Database, we identified 6637 patients with uveitis between 2000 and 2012...
May 9, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28413099/second-line-biologic-therapy-optimization-in-rheumatoid-arthritis-psoriatic-arthritis-and-ankylosing-spondylitis
#10
REVIEW
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Ennio Giulio Favalli, Andrea Becciolini, Maurizio Benucci, Francesca Li Gobbi, Serena Guiducci, Rosario Foti, Marta Mosca, Delia Goletti
OBJECTIVE: The Italian board for the TAilored BIOlogic therapy (ITABIO) reviewed the most consistent literature to indicate the best strategy for the second-line biologic choice in patients with rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA). METHODS: Systematic review of the literature to identify English-language articles on efficacy of second-line biologic choice in RA, PsA, and ankylosing spondylitis (AS). Data were extracted from available randomized, controlled trials, national biologic registries, national healthcare databases, post-marketing surveys, and open-label observational studies...
March 22, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28412702/case-control-study-on-dactylitis-enthesitis-and-anterior-uveitis-in-spondyloarthritis-associated-with-inflammatory-bowel-diseases-role-of-coexistent-psoriasis
#11
Fabrizio Cantini, Laura Niccoli, Carlotta Nannini, Emanuele Cassarà, Olga Kaloudi, Fernando Rizzello, Paolo Gionchetti
OBJECTIVE: To evaluate the frequency of dactylitis, enthesitis, and anterior uveitis (AU) in spondyloarthritis (SpA) associated with inflammatory bowel disease (IBD-SpA) compared with other SpA, and to assess the role of associated psoriasis in the occurrence of dactylitis and enthesitis. METHODS: In a 12-month case-control study, the frequency of dactylitis and enthesitis in 29 patients with ulcerative colitis (UC) and 59 with Crohn disease (CD) who satisfied the Spondyloarthritis international Society criteria for axial or peripheral SpA was compared with 176 controls, including 97 (55...
April 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28386763/ankylosing-spondylitis-hla-b-27-positive-versus-hla-b-27-negative-disease
#12
REVIEW
Nurullah Akkoç, Handan Yarkan, Gökçe Kenar, Muhammad A Khan
PURPOSE OF REVIEW: We review our current knowledge about the clinical features of patients with ankylosing spondylitis (AS) who possess HLA-B*27 versus those who lack this gene. RECENT FINDINGS: ERAP1 association is present only in HLA-B*27+ patients, but other genetic associations are similar between the two groups. A genetic study supports the existence of an HLA-B27-independent common link between gut inflammation and AS. It is unusual to observe familial occurrence of primary AS among families of northern European extraction that show no segregation of HLA-B*27, psoriasis, or IBD...
May 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28384720/mirna-copy-number-variants-confer-susceptibility-to-acute-anterior-uveitis-with-or-without-ankylosing-spondylitis
#13
Lu Yang, Liping Du, Yingying Yue, Yike Huang, Qingyun Zhou, Shuang Cao, Jian Qi, Liang Liang, Lili Wu, Chaokui Wang, Zi Ye, Yuan Tian, Aize Kijlstra, Shengping Hou, Peizeng Yang
Purpose: To investigate the association of microRNA (miRNA) copy number variants (CNVs) with acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) and to assess underlying disease mechanisms. Methods: This study included 768 patients with AAU+AS+ or AAU+AS- and 660 controls from a Chinese Han population. Genotyping of CNVs was performed by TaqMan PCR. The expression of miRNAs, transfection efficiency of miR-9-3, and cytokine production were measured by real-time PCR, flow cytometry, or ELISA...
April 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28254789/tumour-necrosis-factor-inhibitor-treatment-and-occurrence-of-anterior-uveitis-in-ankylosing-spondylitis-results-from-the-swedish-biologics-register
#14
Elisabeth Lie, Ulf Lindström, Tatiana Zverkova-Sandström, Inge C Olsen, Helena Forsblad-d'Elia, Johan Askling, Meliha C Kapetanovic, Lars Erik Kristensen, Lennart T H Jacobsson
OBJECTIVES: Tumour necrosis factor-α inhibitor (TNFi) treatment has been shown to reduce the rates of anterior uveitis (AU) in patients with ankylosing spondylitis (AS). Our objective was to compare the effect of adalimumab (ADA), etanercept (ETN) and infliximab (IFX) on AU occurrence in AS, using real-world data. METHODS: Patients with AS starting ADA, ETN or IFX as their first TNFi from January 2003 to December 2010 were extracted from the Swedish Rheumatology Quality Register...
March 2, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28197814/choroidal-thickness-changes-determined-by-edi-oct-on-acute-anterior-uveitis-in-patients-with-hla-b27-positive-ankylosing-spondylitis
#15
Berna Basarir, Ugur Celik, Cigdem Altan, Nimet Burcu Celik
PURPOSE: To evaluate the choroidal thickness on acute anterior uveitis in patients with HLA-B27-positive ankylosing spondylitis. METHODS: In this study, 32 eyes of 16 HLA-B27 positive AS patients with anterior uveitis and age-matched 19 eyes for control group were analyzed between January 2014 and April 2015. Assessment criteria were uveitis activity, visual acuity, flare existence, subfoveal choroidal thickness and central macular thickness measurements. RESULTS: The mean subfoveal choroidal thicknesses in affected eye group (Group 1), unaffected eye group (Group 2) and control group (Group 3) were 348...
February 14, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28124984/acute-anterior-uveitis-as-a-risk-factor-of-ankylosing-spondylitis-a-national-population-based-study
#16
COMPARATIVE STUDY
Ju-Chuan Yen, Chia-An Hsu, Sheng-Huang Hsiao, Min-Huei Hsu
INTRODUCTION: In clinical settings, acute anterior uveitis (AAU) could be the first presentation of ankylosing spondylitis (AS). Based on this hypothesis, we investigate whether AAU is a risk factor in developing AS later by using National Health Insurance Research Database (NHIRD) in Taiwan. MATERIALS AND METHODS: This cohort comparison study used longitudinal Taiwanese NHIRD to probe the relative risk odds of AAU for AS development, and consisted of all patients diagnosed with AAU (n = 5621) (ICD-9-CM codes 364...
January 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28043168/plasma-levels-of-pentraxin-3-in-patients-with-spondyloarthritis
#17
Renato Nisihara, Thelma L Skare, João Otávio Zeni, Henrique Rasera, Karita Lidani, Iara Messias-Reason
CONTEXT: Determining the disease's inflammatory activity in spondyloarthritis (SpA) is difficult although very important as it is this that drives treatment. OBJECTIVE: To investigate if plasma pentraxin-3 (PTX3) could act as an inflammatory marker in SpA. METHODS: Eighty one SpA patients (11 with psoriatic arthritis (PsoA) and 70 with ankylosing spondylitis (AS)) and 90 gender and age paired controls were studied for plasma PTX3 levels by ELISA...
January 17, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/28040243/radiographic-damage-and-progression-of-the-cervical-spine-in-ankylosing-spondylitis-patients-treated-with-tnf-%C3%AE-inhibitors-facet-joints-vs-vertebral-bodies
#18
Fiona Maas, Anneke Spoorenberg, Elisabeth Brouwer, Eveline van der Veer, Hendrika Bootsma, Reinhard Bos, Freke R Wink, Suzanne Arends
OBJECTIVES: To investigate radiographic damage and 4-year progression of the cervical facet joints in a prospective observational cohort of AS patients treated with TNF-α inhibitors, to compare this with damage and progression of the cervical vertebral bodies, and to study the relation with patient characteristics and clinical outcome. METHODS: Patients from the Groningen Leeuwarden AS (GLAS) cohort starting TNF-α inhibitors with baseline and 4-year radiographs were included...
April 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27965977/lack-of-association-between-genetic-polymorphisms-of-jak-stat-signaling-pathway-genes-and-acute-anterior-uveitis-in-han-chinese
#19
Ling Cheng, Hongsong Yu, Yan Jiang, Juan He, Sisi Pu, Xin Li, Li Zhang
Purpose. This study aimed to investigate the association between single nucleotide polymorphisms (SNPs) of JAK-STAT signaling pathway genes and acute anterior uveitis (AAU) with or without ankylosing spondylitis (AS) in the Han Chinese population. Methods. Eleven SNPs of the JAK1, JAK2, STAT1, IRF1, and NOS2 genes were analyzed in 443 AAU patients with AS, 486 AAU patients without AS, and 714 healthy controls. Genotyping was performed by PCR-RFLP assay or TaqMan® probe assay. The Chi-squared (χ(2)) test and multivariate logistic regression analysis were used to compare the distributions of alleles and genotypes between patients and controls...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27964790/the-eye-and-inflammatory-rheumatic-diseases-the-eye-and-rheumatoid-arthritis-ankylosing-spondylitis-psoriatic-arthritis
#20
REVIEW
Philip Ian Murray, Saaeha Rauz
Rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis are associated with potentially sight-threatening inflammatory eye disease. Although the ocular manifestations associated with ankylosing spondylitis and psoriatic arthritis are similar, such as anterior uveitis, this differs from rheumatoid arthritis where dry eye, peripheral ulcerative keratitis and scleritis are the major ocular complications. Apart from causing sight loss, these conditions are painful, debilitating, often recurrent or chronic and may require long-term therapy...
October 2016: Best Practice & Research. Clinical Rheumatology
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