Read by QxMD icon Read

Uveitis in Ankylosing Spondylitis

Elizabeth J Chen, Muhammad Amir Bin Ismail, Helen Mi, Su Ling Ho, Wee Kiak Lim, Stephen C Teoh, Rupesh Agrawal
PURPOSE: To report the epidemiology and classification of ocular inflammation at a tertiary eye care center in Singapore. METHODS: Retrospective cohort study of the clinical records of consecutive new cases from the Ocular Autoimmune Systemic Inflammatory Infectious Study (OASIS) database from 2004-2015. RESULTS: A total of 2200 patients were studied from the OASIS database. The most common anatomic diagnosis was anterior uveitis (55.9%), posterior uveitis (17...
December 5, 2016: Ocular Immunology and Inflammation
Thelma L Skare, Renato Nisihara, Juliana Z Cieslinski, João O Zeni, Henrique N Rasera, Iara Messias-Reason, Shirley R R Utiyama
BACKGROUND: Infections are usually involved in the pathogenesis of spondyloarthritis (SpA). Mannose-binding lectin (MBL) is a component of the innate immune system with an important role in microbial defense. OBJECTIVE: To study the prevalence of MBL deficiency in SpA patients as well as its influence in the clinical profile of these diseases. METHODS: We studied 89 SpA patients and 89 healthy individuals, paired for age and gender. MBL serum levels were measured by ELISA test...
December 2, 2016: Immunological Investigations
Gareth T Jones, Tiara Ratz, Linda E Dean, Gary J Macfarlane, Fabiola Atzeni
Objectives To examine the relationship between smoking, smoking cessation, and disease characteristics/quality of life (QoL) in spondyloarthritis. Methods The Scotland Registry for Ankylosing Spondylitis collects data from clinically diagnosed patients with spondyloarthritis. Clinical data, including Bath Ankylosing Spondylitis indices of disease activity (BASDAI) and function (BASFI), was obtained from medical records. Postal questionnaires provided information on smoking status and QoL (Ankylosing Spondylitis QoL questionnaire; ASQoL)...
November 29, 2016: Arthritis Care & Research
Peizeng Yang, Zi Ye, Jihong Tang, Liping Du, Qingyun Zhou, Jian Qi, Liang Liang, Lili Wu, Chaokui Wang, Mei Xu, Yuan Tian, Aize Kijlstra
PURPOSE: To characterize the clinical features of scleritis in Chinese patients. METHODS: The history, demographics, ocular findings, auxiliary examination findings, complications, systemic diseases and therapeutic effects were analyzed retrospectively. RESULTS: The study included 124 male and 169 female patients with scleritis. Anterior and posterior scleritis were, respectively, found in 243 and 42 patients. The other eight patients had both anterior and posterior involvement...
November 16, 2016: Ocular Immunology and Inflammation
Chenqiong Wang, Ye Miao, Xuefen Wu, Yishu Huang, Mengchen Sun, Yingzi Zhu, Fang Zheng, Wei Sun, Lingli Dong
Objective. High mobility group box 1 (HMGB1) is a late inflammatory factor participating in the pathogenesis of various autoimmune and inflammatory diseases. In the current study, we analyzed the association between serum levels of HMGB1 and clinical features of AS patients before and during treatment. Methods. Serum HMGB1 was detected in 147 AS patients and 61 healthy controls using ELISA. We evaluated the association between HMGB1 and extra-articular manifestations as well as disease severity indices. Among these AS patients, 41 patients received close follow-up at 1, 3, and 6 months after treatment...
2016: Journal of Immunology Research
T C Mitulescu, C Stavaru, L M Voinea, L M Banica, C Matache, D Predeteanu
Hypothesis:Abnormal Vitamin D (Vit D) level could have consequences on the immuno-inflammatory processes in Ankylosing Spondylitis (AS). Aim:The purpose of this study was to analyze the role of Vitamin D in the interplay between immune and inflammation effectors in AS associated-Acute Anterior Uveitis (AAU). Methods and Results:25-hydroxyvitamin D (Vit D), LL-37 peptide, IL-8 and Serum Amyloid A (SAA) were identified and quantified in the serum/ plasma of thirty-four AS patients [eleven AS patients presenting AAU (AAU AS patients) and twenty-three AS patients without AAU (wAAU AS patients)] and eighteen healthy individuals (Control) using enzyme-linked immunosorbent assay...
January 2016: Journal of Medicine and Life
Claudia Fabiani, Antonio Vitale, Giuseppe Lopalco, Florenzo Iannone, Bruno Frediani, Luca Cantarini
The purpose of the present review was to provide a comprehensive picture of the efficacy of the different tumor necrosis factor (TNF)-α inhibiting agents in the treatment of acute anterior uveitis (AAU), the most common extra-articular manifestation of ankylosing spondylitis (AS). AS related, AAU may lead to severe visual impairment, due to frequent flare recurrences, anterior, and posterior segment complications and traditional treatment side effects. Considerably higher levels of tumor necrosis factor (TNF) have been assessed in the aqueous humor and inflamed joints of patients with AS...
November 2016: Clinical Rheumatology
Mohammad Reza Zamani, Saeed Aslani, Arash Salmaninejad, Mohammad Reza Javan, Nima Rezaei
Programmed death 1 (PD-1) and its ligands, namely PD-L1 and PD-L2, are one of the key factors responsible for inhibitory T cell signaling, mediating the mechanisms of tolerance and providing immune homeostasis. Mounting evidence demonstrates that impaired PD-1:PD-L function plays an important role in a variety of autoimmune diseases such as Type 1 diabetes (T1D), encephalomyelitis, inflammatory bowel diseases (IBD), Rheumatoid Arthritis (RA), autoimmune hepatitis (AIH), Behcet's disease (BD), myasthenia gravis (MG), autoimmune uveitis (AU), Sjögren's syndrome (SjS), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), myocarditis, and ankylosing spondylitis (AS)...
September 15, 2016: Cellular Immunology
Christelle Domngang Noche, Giles Kagmeni, Viola Dohvoma, Assumpta Lucienne Bella, Come Ebana Mvogo, Madeleine Singwe-Ngandeu
PURPOSE: To determine the profile of ophthalmic manifestations in chronic inflammatory rheumatic diseases (CIRD). METHODS: Observational study at the Yaounde Central Hospital and Innel Medical Centre (2004 to 2012). RESULTS: The study population (n = 36) consisted of 14 men and 22 women with average age of 47.9 ± 17.2 years. Cases of CIRD were rheumatoid arthritis (n = 16), systemic lupus erythematosus (n = 8), ankylosing spondylitis (n = 8), mixed connective tissue disease (n = 2), scleroderma (n = 1), and juvenile idiopathic arthritis (n = 1)...
September 6, 2016: Ocular Immunology and Inflammation
Janneke J de Winter, Leonieke J van Mens, Désirée van der Heijde, Robert Landewé, Dominique L Baeten
BACKGROUND: Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis (nr-axSpA). So far, however, summary data on the prevalence are lacking. The objective of this meta-analysis was to assess the prevalence of peripheral and extra-articular manifestations in ankylosing spondylitis (AS) and nr-axSpA. METHODS: We performed a systematic literature search to identify publications describing the prevalence of peripheral and extra-articular disease manifestations in patients with AS and nr-axSpA...
September 1, 2016: Arthritis Research & Therapy
Joo Yong Lee, Dong Yoon Kim, Se Joon Woo, Tae Wan Kim, Sang Jin Kim, Christopher Seungkyu Lee, Kyu Seop Kim, Kyung Hoon Seo, Hyung Woo Kwak
PURPOSE: To identify the characteristics and causes of uveitis in Seoul, South Korea. METHODS: We performed a retrospective medical record review of 602 patients diagnosed with uveitis at seven tertiary ophthalmology centers between January and December 2013. RESULTS: The most common type of uveitis was anterior uveitis (n = 281), followed by posterior uveitis (n = 152), panuveitis (n = 126), and intermediate uveitis (n = 43). Among patients with an identified cause (n = 252), 149 and 103 had non-infectious and infectious uveitis, respectively, and ankylosing spondylitis (n = 53), Behcet disease (n = 43), and endophthalmitis (n = 25) were common identified causes of uveitis...
August 19, 2016: Ocular Immunology and Inflammation
Mirinae Kim, Jae-Yon Won, Seung Yong Choi, Ji Hyeon Ju, Young-Hoon Park
PURPOSE: To assess the long-term efficacy of the most widely used anti-tumor necrosis factor alpha (TNFα) agents for treatment of HLA-B27-positive ankylosing spondylitis (AS)-related uveitis. DESIGN: Retrospective cohort study. METHODS: The medical records of 143 patients with HLA-B27-positive AS who visited Seoul St. Mary's Hospital and were taking an anti-TNFα agent for at least 1 year were studied. Subjects were divided into 3 groups according to anti-TNFα treatment: Group 1 (infliximab, 66), Group 2 (adalimumab, 45), and Group 3 (etanercept, 32)...
October 2016: American Journal of Ophthalmology
F Nilüfer Yalçındağ, Pınar C Özdal, Yılmaz Özyazgan, Figen Batıoğlu, Ilknur Tugal-Tutkun
PURPOSE: To describe the demographic and clinical profiles of uveitis patients seen at secondary and tertiary care centers in Turkey. METHODS: A nationwide web-based registry of patients with uveitis was initiated in November 2008. We analyzed data from a single baseline registry-enrollment visit. RESULTS: In 33 centers, 6967 eyes of 4863 consecutive patients were registered. The mean age at presentation was 36.6 ± 15.7 (1-92) years; 51.3% were male...
July 28, 2016: Ocular Immunology and Inflammation
Li Sun, Rui Wu, Qin Xue, Feng Wang, Peirong Lu
BACKGROUND: Uveitis is the most common extra-articular manifestation in patients with ankylosing spondylitis (AS). The prevalence and characteristics of uveitis in AS have been studied in previous literatures, whereas its associated risk factors have not been clarified. Therefore, this study analyzed the risk factors of uveitis in patients with AS. METHODS: A total of 390 patients with AS who fulfilled the modified New York criteria were enrolled from January to December in 2015...
July 2016: Medicine (Baltimore)
Haibo Li, Qiuxia Li, Chen Ji, Jieruo Gu
PURPOSE: To investigate the correlation between clinical features of ankylosing spondylitis (AS) and different human leukocyte antigen (HLA)-B27 subtypes. METHODS: We conducted a cross-sectional study of 216 patients with AS. HLA-B27 and its subtypes were detected by polymerase chain reaction with sequence specific primer (PCR-SSP). Clinical features were compared between the different HLA-B27 subtypes. A meta-analysis on uveitis frequencies in AS patients with HLA-B*2705 vs 2704 was performed...
July 18, 2016: Ocular Immunology and Inflammation
Q F Wang, X F Huang, Z L Zheng, M L Dai, W J Cai, M M Yang, Z B Jin, Y Q Wang
PurposeCD59 complement regulator and complement factor H (CFH) have important roles in complement activation pathways, which are known to affect the development of uveitis. The present study was performed to investigate whether an association exists between CD59 and CFH genetic polymorphisms and acute anterior uveitis (AAU).MethodsA total of 600 individuals (300 patients diagnosed with AAU and 300 healthy controls) were recruited for this case-control study. Five single-nucleotide polymorphisms (SNPs) in CD59 (rs831626, rs12272807, rs831625, rs11585, and rs12576440) and CFH-rs1065489 were genotyped using Sequenom MassARRAY technology...
July 15, 2016: Eye
Kemal Nas, Erhan Capkin, Abdullah Zübeyir Dagli, Remzi Cevik, Erkan Kilic, Gamze Kilic, Murat Karkucak, Bekir Durmus, Salih Ozgocmen
OBJECTIVES: To assess gender related differences in a cohort of patients with psoriatic arthritis (PsA). METHODS: Consecutively recruited patients were included and underwent clinical, radiological and laboratory evaluation by using standardized protocol and case report forms. RESULTS: Women (n = 115) with PsA had higher symptom duration and body mass index (BMI), tender and swollen joint counts, disease activity score-28 joints (DAS28), Erythrocyte sedimentation rate (ESR) and poorer physical activity and fatigue than men (n = 72) with PsA...
July 14, 2016: Modern Rheumatology
Amra Adrovic, Kenan Barut, Sezgin Sahin, Ozgur Kasapcopur
Juvenile spondyloarthropathies represent a clinical entity separate from the adult disease. Initial clinical signs of juvenile spondyloarthropathies often include lower extremity arthritis and enthesopathy, without axial involvement at the disease onset. Asymmetrical oligoarthritis of lower extremities is typically seen in this type of arthritis. Enthesopathy, which is the hallmark of the disease, is most commonly seen in the Achilles tendon, being manifested by heel pain. Anterior uveitis and HLA-B27 positivity are seen in a proportion of cases...
August 2016: Current Rheumatology Reports
Raquel Almodóvar, Victoria Navarro-Compán, Cristina Fernández-Carballido, Azucena Hernández, Eugenio De Miguel, Pedro Zarco
OBJECTIVES: To describe and evaluate clinical and imaging differences between patients with familial and sporadic early spondyloarthritis (SpA). METHODS: This was a cross-sectional study analysing the baseline dataset from ESPERANZA, a national programme developed for the early identification of patients with SpA. Patients fulfilling SpA ASAS classification criteria were included. Familial SpA was defined according to the ASAS/ESSG criteria as the presence in first- or second-degree relatives of any of the following: ankylosing spondylitis, psoriasis, uveitis, reactive arthritis, and inflammatory bowel disease...
July 2016: Clinical and Experimental Rheumatology
Fereydoun Davatchi, Cheyda Chams-Davatchi, Hormoz Shams, Farhad Shahram, Abdolhadi Nadji, Massoomeh Akhlaghi, Tahreh Faezi, Zahra Ghodsi, Bahar Sadeghi Abdollahi, Farimah Ashofteh, Negin Mohtasham, Hoda Kavosi, Mariam Masoumi
INTRODUCTION: Behcet's Disease (BD) is classified among vasculitides. The aim of this review was to put together different known reports in order to help the reader to better understand the disease, to avoid the frequent misdiagnosis, and to decide the best treatment. AREAS COVERED: a) Epidemiology: BD is rare, and is seen along the Silk Road, from 20 to 420/100,000 in Turkey and 80/100,000 in Iran, to 0.64/100,000 in the UK. b) Clinical manifestations: oral aphthosis is seen in more than 95% of patients, genital aphthosis (60-90%), skin (pseudofolliculitis/erythema nodosum, 40-90%), eyes (uveitis/retinal vasculitis, 45-90%), gastrointestinal (diarrhea/hemorrhage/perforation/pain, 4-38%), vascular (venous/arterial thrombosis, aneurysm, 2...
July 11, 2016: Expert Review of Clinical Immunology
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"