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https://www.readbyqxmd.com/read/28798976/5-ht-modulation-of-pain-perception-in-humans
#1
Sarah L Martin, Andrea Power, Yvonne Boyle, Ian M Anderson, Monty A Silverdale, Anthony K P Jones
INTRODUCTION: Although there is clear evidence for the serotonergic regulation of descending control of pain in animals, little direct evidence exists in humans. The majority of our knowledge comes from the use of serotonin (5-HT)-modulating antidepressants as analgesics in the clinical management of chronic pain. OBJECTIVES: Here, we have used an acute tryptophan depletion (ATD) to manipulate 5-HT function and examine its effects of ATD on heat pain threshold and tolerance, attentional manipulation of nociceptive processing and mood in human volunteers...
August 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28783465/photobiomodulation-in-the-prevention-of-tooth-sensitivity-caused-by-in-office-dental-bleaching-a-randomized-placebo-preliminary-study
#2
Andrea Paiva Corsetti Calheiros, Maria Stella Moreira, Flávia Gonçalves, Ana Cecília Correa Aranha, Sandra Ribeiro Cunha, Carolina Steiner-Oliveira, Carlos de Paula Eduardo, Karen Müller Ramalho
OBJECTIVE: Analyze the effect of photobiomodulation in the prevention of tooth sensitivity after in-office dental bleaching. BACKGROUND DATA: Tooth sensitivity is a common clinical consequence of dental bleaching. Therapies for prevention of sensitivity have been investigated in literature. MATERIALS AND METHODS: This study was developed as a randomized, placebo blind clinical trial. Fifty patients were selected (n = 10) and randomly divided into five groups: (1) control, (2) placebo, (3) laser before bleaching, (4) laser after bleaching, and (5) laser before and after bleaching...
August 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28783464/efficacy-of-multiwave-locked-system-laser-on-pain-and-function-in-patients-with-chronic-neck-pain-a-randomized-placebo-controlled-trial
#3
Mohamed Salaheldien Alayat, Ahmed Mohamed Elsoudany, Mohamed Ebrahim Ali
BACKGROUND: Multiwave locked system (MLS) laser therapy utilizes the synchronized emission of an 808 nm continuous laser and a 905 nm pulsed laser. It is postulated that MLS enables greater penetration and therapeutic benefit than single-wavelength low-level laser therapy (LLLT). OBJECTIVE: The aim of this research was to evaluate the efficacies of MLS laser therapy and the 830 nm laser in the treatment of patients with chronic neck pain (CNP). MATERIALS AND METHODS: Seventy-five patients with CNP (mean age 46...
August 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28776408/long-term-results-of-a-randomized-controlled-double-blind-study-of-low-level-laser-therapy-before-exercises-in-knee-osteoarthritis-laser-and-exercises-in-knee-osteoarthritis
#4
Patrícia Pereira Alfredo, Jan Magnus Bjordal, Washington Steagall Junior, Rodrigo Álvaro Brandão Lopes Martins, Martin B Stausholm, Raquel Aparecida Casarotto, Amélia Pasqual Marques, Jon Joensen
OBJECTIVES: To assess the long-term effects of low-level laser therapy (LLLT), in combination with strengthening exercises in patients with osteoarthritis of the knee. DESIGN: Follow-up results at three and six months in a previously published randomized, double-blind, placebo-controlled trial. SETTING: Specialist Rehabilitation Services. SUBJECTS: Forty participants of both genders, aged 50-75 years with knee osteoarthritis grade 2-4 on Kellgren-Lawrence scale...
August 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/28774708/epileptologist-s-view-laser-interstitial-thermal-ablation-for-treatment-of-temporal-lobe-epilepsy
#5
Joon Y Kang, Michael R Sperling
A procedure called laser interstitial thermal ablation has been utilized to treat drug resistant epilepsy. With this technique, a probe is stereotactically inserted into a target structure responsible for seizures, such as mesial temporal lobe, hypothalamic hamartoma, or a small malformation of cortical development, and the tip is then heated by application of laser energy to ablate structures adjacent to the probe tip. This procedure has the advantage of selectively targeting small lesions responsible for seizures, and is far less invasive than open surgery with shorter hospitalization, less pain, and rapid return to normal activities...
July 25, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28772237/low-intensity-laser-therapy-efficacy-evaluation-in-mice-subjected-to-acute-arthritis-condition
#6
Bianca F Trawitzki, Lothar Lilge, Fellipe A T de Figueiredo, Ana Paula Macedo, João Paulo M Issa
Acute arthritis is an inflammation that affects many joints. The principal treatment options comprise drugs (corticosteroids), invasive and painful surgery. The objective of this study was to evaluate the efficacy of low intensity laser therapy (LILT), a non-invasive treatment, in a murine model of acute inflammation model. 48 mice received a synovial injection of Zymosan A into one knee. Mice were treated with LILT by three different wavelengths, either as a single (S) or dual (D) application immediately after the injury or after 24h following initiation of an inflammatory response...
July 26, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28768314/low-dose-naltrexone-treatment-of-familial-benign-pemphigus-hailey-hailey-disease
#7
Omer Ibrahim, Sara R Hogan, Alok Vij, Anthony P Fernandez
Importance: Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare and debilitating genetic dermatosis characterized by chronic, recurrent vesicles, erosions, and maceration in flexural areas. Despite the reported therapeutic modalities, such as topical and systemic corticosteroids, systemic immunomodulators, topical and systemic retinoids, and laser, HHD can still be markedly difficult to control. Objective: To assess low-dose naltrexone hydrochloride in the treatment of recalcitrant HHD...
August 2, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28763401/randomized-double-blind-placebo-controlled-clinical-trial-for-evaluating-the-efficacy-of-fractional-co2-laser-compared-with-topical-estriol-in-the-treatment-of-vaginal-atrophy-in-postmenopausal-women
#8
Vera L Cruz, Marcelo L Steiner, Luciano M Pompei, Rodolfo Strufaldi, Fernando L Afonso Fonseca, Lucila H Simardi Santiago, Tali Wajsfeld, Cesar E Fernandes
OBJECTIVE: The aim of the study was to evaluate efficacy of fractional CO2 vaginal laser treatment (Laser, L) and compare it to local estrogen therapy (Estriol, E) and the combination of both treatments (Laser + Estriol, LE) in the treatment of vulvovaginal atrophy (VVA). METHODS: A total of 45 postmenopausal women meeting inclusion criteria were randomized in L, E, or LE groups. Assessments at baseline, 8 and 20 weeks, were conducted using Vaginal Health Index (VHI), Visual Analog Scale for VVA symptoms (dyspareunia, dryness, and burning), Female Sexual Function Index, and maturation value (MV) of Meisels...
July 31, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28758261/comparison-of-two-picosecond-lasers-to-a-nanosecond-laser-for-treating-tattoos-a-prospective-randomized-study-on-49-patients
#9
Aurélie Lorgeou, Yvon Perrillat, Nathalie Gral, Sylvie Lagrange, Jean-Philippe Lacour, Thierry Passeron
BACKGROUND: Q-switched nanosecond lasers demonstrated their efficacy in treating most types of tattoos but complete disappearance is not always achieved even after performing numerous laser sessions. Picosecond lasers are supposed to be more efficient in clearing tattoos than nanosecond lasers but prospective comparative data remain limited. OBJECTIVE: To compare on different types of tattoos the efficacy of a nanosecond laser with two types of picosecond lasers...
July 31, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28758247/pulsed-dye-laser-treatment-of-port-wine-stains-in-children-useful-tips-to-avoid-general-anesthesia
#10
Adrián Alegre-Sánchez, Bibiana Pérez-García, Pablo Boixeda
Pulsed dye laser (PDL) treatment of port-wine stains (PWSs) in children is a common procedure performed in most laser units. Pain assessment in our younger patients is a major concern, especially in those with extensive PWSs. The use of general anesthesia (GA) results in pain-free treatment, but its effects on the developing brain are far from totally understood. Thus we propose some tips that avoid the use of GA in most of our young patients, including the use of topical anesthetics and cooling systems, large laser spot size and high frequencies, early and frequent treatment with parents present, and the "introduction" and "pressure" techniques, among others...
July 30, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28757697/corneal-ring-infiltration-in-contact-lens-wearers
#11
Seyed Ali Tabatabaei, Mohammad Soleimani, Mohammadkarim Johari
To report a case of atypical sterile ring infiltrates during wearing soft silicone hydrogel contact lens due to poor lens care. A 29-year-old woman presented with complaints of pain, redness, and morning discharge. She was wearing soft silicone hydrogel contact lens previously; her current symptoms began 1 week before presentation. On examination, best-corrected visual acuity was 20/40 in that eye. Slit-lamp examination revealed dense, ring-shaped infiltrate involving both the superficial and deep stromal layers with lucid interval to the limbus, edema of the epithelium, epithelial defect, and vascularization of the superior limbus...
May 2017: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/28756997/treatment-of-oral-lichen-planus-systematic-review-and-therapeutic-guide
#12
REVIEW
María José García-Pola, Laura González-Álvarez, José M Garcia-Martin
In this systematic review, 55 structured articles on the therapeutic efficacy against pain and clinical signs of oral lichen planus (OLP) were analysed. The literature search was developed according to the criteria of the PRISMA system, selecting the tests performed using one of the following methodological designs: drug (active ingredient) vs. drug in different excipient or concentration, drug vs. different active principle, drug vs. phytotherapy and drug vs. treatment with phototherapy. Based on the results, an algorithm is proposed to guide the treatment of OLP in its atrophic and erosive clinical forms...
July 27, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28753078/which-is-more-effective-for-pain-relief-during-fractionated-carbon-dioxide-laser-treatment-emla-cream-or-forced-cold-air-anesthesia
#13
Elif Sari, Bulent Bakar
BACKGROUND AND AIM: The aim of this study was to compare the effectiveness of a eutectic mixture of local anesthetic (EMLA) cream and forced cold air anesthesia (FCAA) on pain control during ablative fractionated carbon dioxide (CO2) laser treatment. METHODS: Fifteen volunteers participated in this prospective, controlled, split-face clinical study. EMLA cream was applied 60 minutes before the laser procedure on half of the face, and FCAA was performed on each subunit of the other half of the face...
July 28, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28752263/photobiomodulation-therapy-by-nir-laser-in-persistent-pain-an-analytical-study-in-the-rat
#14
Laura Micheli, Lorenzo Di Cesare Mannelli, Elena Lucarini, Francesca Cialdai, Leonardo Vignali, Carla Ghelardini, Monica Monici
Over the past three decades, physicians have used laser sources for the management of different pain conditions obtaining controversial results that call for further investigations. In order to evaluate the pain relieving possibilities of photobiomodulation therapy (PBMT), we tested two near infrared (NIR) laser systems, with different power, against various kinds of persistent hyperalgesia animal models. In rats, articular pain was reproduced by the intra-articular injection of sodium monoiodoacetate (MIA) and complete Freund's adjuvant (CFA), while compressive neuropathy was modelled by the chronic constriction injury of the sciatic nerve (CCI)...
July 28, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28750962/conservative-management-of-temporomandibular-dysfunction-a-literature-review-with-implications-for-clinical-practice-guidelines-narrative-review-part-2
#15
REVIEW
Raymond Butts, James Dunning, Ron Pavkovich, Jersey Mettille, Firas Mourad
The effective management of temporomandibular dysfunction (TMD) requires a thorough understanding of the pathoanatomic factors that drive the underlying condition. After reviewing the etiology associated with TMD in Part 1 of this narrative review, the temporomandibular joint capsule, articular disc and muscles of mastication emerged as key players. (http://dx.doi.org/10.​1016/​j.​jbmt.​2017.​05.​017) Part 2 focuses on conservative treatment strategies best able to reduce the pain and disability associated with TMD...
July 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28748217/mechanisms-and-applications-of-the-anti-inflammatory-effects-of-photobiomodulation
#16
Michael R Hamblin
Photobiomodulation (PBM) also known as low-level level laser therapy is the use of red and near-infrared light to stimulate healing, relieve pain, and reduce inflammation. The primary chromophores have been identified as cytochrome c oxidase in mitochondria, and calcium ion channels (possibly mediated by light absorption by opsins). Secondary effects of photon absorption include increases in ATP, a brief burst of reactive oxygen species, an increase in nitric oxide, and modulation of calcium levels. Tertiary effects include activation of a wide range of transcription factors leading to improved cell survival, increased proliferation and migration, and new protein synthesis...
2017: AIMS Biophysics
https://www.readbyqxmd.com/read/28744993/clinical-radiological-and-gene-expression-analyses-in-smokers-and-non-smokers-part-2-rct-on-the-late-healing-phase-of-osseointegration
#17
Shariel Sayardoust, Omar Omar, Ola Norderyd, Peter Thomsen
BACKGROUND: The mechanisms behind the impact of smoking on osseointegration are not fully understood. PURPOSE: To investigate the initial clinical and molecular course of osseointegration of different implants in smokers and non-smokers in a randomized controlled trial (RCT). MATERIALS AND METHODS: Smoking (n = 16) and non-smoking (n = 16) patients received 3 implant types: machined, oxidized, and laser-modified surfaces. Baseline bone biopsies were retrieved from the implant sites...
July 26, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28741435/effect-of-ankle-position-and-noninvasive-distraction-on-arthroscopic-accessibility-of-the-distal-tibial-plafond
#18
Craig C Akoh, Kevin Dibbern, Annuziato Amendola, Tinnart Sittapairoj, Donald D Anderson, Phinit Phisitkul
BACKGROUND: Osteochondral lesions of the tibial plafond (OLTPs) can lead to chronic ankle pain and disability. It is not known how limited ankle motion or joint distraction affects arthroscopic accessibility of these lesions. The purpose of this study was to determine the effects of different fixed flexion angles and distraction on accessibility of the distal tibial articular surface during anterior and posterior arthroscopy. METHODS: Fourteen below-knee cadaver specimens underwent anterior and posterior ankle arthroscopy using a 30-degree 2...
July 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28740327/static-and-dynamic-modes-of-810-nm-diode-laser-hair-removal-compared-a-clinical-and-histological-study
#19
Tokuya Omi
BACKGROUND AND AIMS: Laser hair removal has recently become a major indication. Diode lasers have become commercially available offering two modes of application: a stamping or static mode, and a dynamic mode whereby the handpiece is continuously moved across the target tissue. The present study was designed to compare the efficacy of these two approaches clinically and histologically. SUBJECTS AND METHODS: Twenty-five subjects participated in the study, 12 males and 13 females, ages ranging from 20 to 57 yr (Mean age 41...
March 31, 2017: Laser Therapy
https://www.readbyqxmd.com/read/28740325/low-level-laser-therapy-in-patients-with-chronic-foot-and-ankle-joint-pain
#20
Hideaki Izukura, Midori Miyagi, Takashi Harada, Toshio Ohshiro, Satoru Ebihara
BACKGROUND AND AIMS: Chronic foot and ankle joint pain is one of the most frequent complaints which is regularly seen in the out-patient clinic of our medical institute. In previous studies we have reported on the benefits of low level laser therapy (LLLT) for chronic pain in the elbow, hand, finger and the lower back. The present study examined the effects of LLLT on chronic foot and ankle joint pain. MATERIALS AND METHODS: Over the past 5 years, 17 subjects visited the out-patient clinic with complaints of chronic foot and ankle joint pain of a variety of aetiologies...
March 31, 2017: Laser Therapy
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