Matúš Miklovič, Olga Gawryś, Zuzana Honetschlägerová, Petr Kala, Zuzana Husková, Soňa Kikerlová, Zdeňka Vaňourková, Šárka Jíchová, Alena Kvasilová, Misuzu Kitamoto, Hana Maxová, Guillermo Puertas-Frias, Tomáš Mráček, David Sedmera, Vojtěch Melenovský
Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable by a decrease in vascular afterload, or diminished neurohumoral response in the kidneys, or whether RDN procedure per se has direct myocardial effects in the failing heart. To elucidate mechanisms how RDN affects failing heart, we studied load-independent indexes of ventricular function, gene markers of myocardial remodeling, and cardiac sympathetic signaling in HF, induced by chronic volume overload (aorto-caval fistula, ACF) of Ren2 transgenic rats...
February 2, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension