keyword
https://read.qxmd.com/read/38406842/beating-the-heart-failure-odds-long-term-survival-after-myocardial-ischemia-in-juvenile-rainbow-trout
#21
JOURNAL ARTICLE
Lucas A Zena, Andreas Tommy Ekström, Daniel Morgenroth, Tristan McArley, Michael Axelsson, Henrik Sundh, Anders Palmquist, Ida B Johansen, Albin Gräns, Erik Sandblom
Salmonid fish include some of the most valued cultured fish species worldwide. Unlike most other fish, the hearts of salmonids, including Atlantic salmon and rainbow trout, have a well-developed coronary circulation. Consequently, their hearts' reliance on oxygenation through coronary arteries leaves them prone to coronary lesions, believed to precipitate myocardial ischemia. Here, we mimicked such coronary lesions by subjecting groups of juvenile rainbow trout to coronary ligation, assessing histo-morphological myocardial changes associated with ischemia and scarring in the context of cardiac arrhythmias using electrocardiography (ECG)...
February 26, 2024: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://read.qxmd.com/read/38405927/human-ipsc-derived-committed-cardiac-progenitors-generate-cardiac-tissue-grafts-in-a-swine-ischemic-cardiomyopathy-model-without-triggering-ventricular-arrhythmias
#22
Amish N Raval, Eric G Schmuck, Sushmita Roy, Yukihiro Saito, Tianhua Zhou, James Conklin, Timothy A Hacker, Chad Koonce, Meghan Boyer, Kristin Stack, Ellen Hebron, Scott K Nagle, Patrick C H Hsieh, Timothy J Kamp
BACKGROUND: The adult human heart following a large myocardial infarction is unable to regenerate heart muscle and instead forms scar with the risk of progressive heart failure. Large animal studies have shown that intramyocardial injection of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) following a myocardial infarction result in cell grafts but also ventricular arrhythmias. We hypothesized that intramyocardial injection of committed cardiac progenitor cells (CCPs) derived from iPSCs, combined with cardiac fibroblast-derived extracellular matrix (cECM) to enhance cell retention will: i) form cardiomyocyte containing functional grafts, ii) be free of ventricular arrhythmias and iii) restore left ventricular contractility in a post-myocardial infarction (MI) cardiomyopathy swine model...
February 17, 2024: bioRxiv
https://read.qxmd.com/read/38395031/decreasing-microtubule-detyrosination-modulates-nav1-5-subcellular-distribution-and-restores-sodium-current-in-mdx-cardiomyocytes
#23
JOURNAL ARTICLE
Giovanna Nasilli, Tanja M de Waal, Gerard A Marchal, Giorgia Bertoli, Marieke W Veldkamp, Eli Rothenberg, Simona Casini, Carol Ann Remme
BACKGROUND: The microtubule (MT) network plays a major role in the transport of the cardiac sodium channel Nav1.5 to the membrane, where the latter associates with interacting proteins such as dystrophin. Alterations in MT dynamics are known to impact on ion channel trafficking. Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, is associated with an increase in MT detyrosination, decreased sodium current (INa), and arrhythmias. Parthenolide (PTL), a compound that decreases MT detyrosination, has shown beneficial effects on cardiac function in DMD, but its impact on INa has not been investigated...
February 23, 2024: Cardiovascular Research
https://read.qxmd.com/read/38385289/inhibition-of-il-1-ameliorates-cardiac-dysfunction-and-arrhythmias-in-a-murine-model-of-kawasaki-disease
#24
JOURNAL ARTICLE
Thassio Mesquita, Yen-Nien Lin, Shuang Chen, Youngho Lee, Rodrigo Miguel-Dos-Santos, Asli E Atici, Michael C Fishbein, Magali Noval Rivas, Moshe Arditi, Eugenio Cingolani
BACKGROUND: Kawasaki disease (KD) is an acute febrile illness and systemic vasculitis often associated with cardiac sequelae, including arrhythmias. Abundant evidence indicates a central role for IL (interleukin)-1 and TNFα (tumor necrosis factor-alpha) signaling in the formation of arterial lesions in KD. We aimed to investigate the mechanisms underlying the development of electrophysiological abnormalities in a murine model of KD vasculitis. METHODS: Lactobacillus casei cell wall extract-induced KD vasculitis model was used to investigate the therapeutic efficacy of clinically relevant IL-1Ra (IL-1 receptor antagonist) and TNFα neutralization...
February 22, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38370154/predictors-of-left-ventricular-ejection-fraction-in-high-risk-percutaneous-coronary-interventions
#25
JOURNAL ARTICLE
Vasileios F Panoulas, Javier Escaned, Jonathan M Hill, Erin Barker, Karin Butler, Ali Almedhychy, Stelios I Tsintzos, William W O'Neill
Revascularization completeness after percutaneous coronary intervention (PCI) is associated with improved long-term outcomes. Mechanical circulatory support [intra-aortic balloon pump (IABP) or Impella] is used during high-risk PCI (HR-PCI) to enhance peri-procedural safety and achieve more complete revascularization. The relationship between revascularization completeness [post-PCI residual SYNTAX Score (rSS)] and left ventricular ejection fraction (LVEF) in HR-PCI has not been established. We investigated LVEF predictors at 90 days post-PCI with Impella or IABP support...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38362779/fars2-deficiency-causes-cardiomyopathy-by-disrupting-mitochondrial-homeostasis-and-the-mitochondrial-quality-control-system
#26
JOURNAL ARTICLE
Bowen Li, Fangfang Liu, Xihui Chen, Tangdong Chen, Juan Zhang, Yifeng Liu, Yan Yao, Weihong Hu, Mengjie Zhang, Bo Wang, Liwen Liu, Kun Chen, Yuanming Wu
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a common heritable myocardiopathy. Although HCM has been reported to be associated with many variants of genes involved in sarcomeric protein biomechanics, pathogenic genes have not been identified in patients with partial HCM. FARS2 (the mitochondrial phenylalanyl-tRNA synthetase), a type of mitochondrial aminoacyl-tRNA synthetase, plays a role in the mitochondrial translation machinery. Several variants of FARS2 have been suggested to cause neurological disorders; however, FARS2-associated diseases involving other organs have not been reported...
February 16, 2024: Circulation
https://read.qxmd.com/read/38345870/role-of-tissue-biomechanics-in-the-formation-and-function-of-myocardial-trabeculae-in-zebrafish-embryos
#27
JOURNAL ARTICLE
Adriana Gaia Cairelli, Alex Gendernalik, Wei Xuan Chan, Phuc Nguyen, Julien Vermot, Juhyun Lee, David Bark, Choon Hwai Yap
Cardiac trabeculae are uneven ventricular muscular structures that develop during early embryonic heart development at the outer curvature of the ventricle. Their biomechanical function is not completely understood, and while their formation is known to be mechanosensitive, it is unclear whether ventricular tissue internal stresses play an important role in their formation. Here, we performed imaging and image-based cardiac biomechanics simulations on zebrafish embryonic ventricles to investigate these issues...
February 12, 2024: Journal of Physiology
https://read.qxmd.com/read/38335818/experimentally-guided-in-silico-design-of-engineered-heart-tissues-to-improve-cardiac-electrical-function-after-myocardial-infarction
#28
JOURNAL ARTICLE
Ricardo M Rosales, Konstantinos A Mountris, Aida Oliván-Viguera, María Pérez-Zabalza, Gerardo Cedillo-Servin, Olalla Iglesias-García, Andrei Hrynevich, Miguel Castilho, Jos Malda, Felipe Prósper, Manuel Doblaré, Manuel M Mazo, Esther Pueyo
Engineered heart tissues (EHTs) built from human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) showed promising results for cardiac function restoration following myocardial infarction. Nevertheless, human iPSC-CMs have longer action potential and lower cell-to-cell coupling than adult-like CMs. These immature electrophysiological properties favor arrhythmias due to the generation of electrophysiological gradients when hiPSC-CMs are injected in the cardiac tissue. Culturing hiPSC-CMs on three-dimensional (3D) scaffolds can promote their maturation and influence their alignment...
February 1, 2024: Computers in Biology and Medicine
https://read.qxmd.com/read/38319719/right-ventricular-cardiomyocyte-expansion-accompanies-cardiac-regeneration-in-newborn-mice-after-large-left-ventricular-infarcts
#29
JOURNAL ARTICLE
Tianyuan Hu, Mona Malek Mohammadi, Fabian Ebach, Michael Hesse, Michael I Kotlikoff, Bernd K Fleischmann
Cauterization of the root of the left coronary artery (LCA) in the neonatal heart at postnatal day 1 (P1) resulted in large reproducible lesions of the left ventricle (LV), and an attendant marked adaptive response in the right ventricle (RV). The response of both chambers to LV myocardial infarction involved enhanced cardiomyocyte (CM) division and binucleation, as well as LV re-vascularization, leading to restored heart function within 7 days post-surgery (7 dps). By contrast, infarction of P3 mice resulted in cardiac scarring without a significant regenerative and adaptive response of the LV and the RV leading to subsequent heart failure and death within 7 dps...
February 6, 2024: JCI Insight
https://read.qxmd.com/read/38317221/hand-factors-regulate-cardiac-lineage-commitment-and-differentiation-from-human-pluripotent-stem-cells
#30
JOURNAL ARTICLE
Huixin Guo, Chengwen Hang, Bowen Lin, Zheyi Lin, Hui Xiong, Mingshuai Zhang, Renhong Lu, Junyang Liu, Dan Shi, Duanyang Xie, Yi Liu, Dandan Liang, Jian Yang, Yi-Han Chen
BACKGROUND: Transcription factors HAND1 and HAND2 (HAND1/2) play significant roles in cardiac organogenesis. Abnormal expression and deficiency of HAND1/2 result in severe cardiac defects. However, the function and mechanism of HAND1/2 in regulating human early cardiac lineage commitment and differentiation are still unclear. METHODS: With NKX2.5eGFP H9 human embryonic stem cells (hESCs), we established single and double knockout cell lines for HAND1 and HAND2, respectively, whose cardiomyocyte differentiation efficiency could be monitored by assessing NKX2...
February 5, 2024: Stem Cell Research & Therapy
https://read.qxmd.com/read/38317144/the-sirna-mediated-knockdown-of-ap-1-restores-the-function-of-the-pulmonary-artery-and-the-right-ventricle-by-reducing-perivascular-and-interstitial-fibrosis-and-key-molecular-players-in-cardiopulmonary-disease
#31
JOURNAL ARTICLE
Ioana Karla Comarița, Gabriela Tanko, Iliuță Laurențiu Anghelache, Adriana Georgescu
BACKGROUND: Pulmonary hypertension (PH) is a complex multifactorial vascular pathology characterized by an increased pulmonary arterial pressure, vasoconstriction, remodelling of the pulmonary vasculature, thrombosis in situ and inflammation associated with right-side heart failure. Herein, we explored the potential beneficial effects of treatment with siRNA AP-1 on pulmonary arterial hypertension (PAH), right ventricular dysfunction along with perivascular and interstitial fibrosis in pulmonary artery-PA, right ventricle-RV and lung in an experimental animal model of monocrotaline (MCT)-induced PAH...
February 5, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38306778/ifitm3-mediates-inflammation-induced-myocardial-injury-through-jak2-stat3-signaling-pathway
#32
JOURNAL ARTICLE
Chunming Xiong, Bohan Li, Renxing Song, Zizhe Ma, Sally A Huber, Wei Liu
Myocarditis is an inflammation of the heart muscle often associated with viral infections and can lead to dilated cardiomyopathy. Interferon-induced transmembrane protein 3 (IFITM3) is a small endosomal membrane protein with anti-viral activity against multiple viruses and is also implicated in non-infectious diseases such as cancer and Alzheimer's Disease. Since the IFITM3 proteins are expressed both in T cells and in cardiomyocytes, it is reasonable to hypothesize that these molecules could affect myocarditis either through their effect on the autoimmune response or through direct modulation of cardiomyocyte damage...
March 2024: Molecular Immunology
https://read.qxmd.com/read/38303706/ultrasound-targeted-microbubble-technology-facilitates-sahh-gene-delivery-to-treat-diabetic-cardiomyopathy-by-activating-ampk-pathway
#33
JOURNAL ARTICLE
Xiaohui Guo, Kegong Chen, Lin Ji, Shanjie Wang, Xiangmei Ye, Liang Xu, Leiguang Feng
Diabetic cardiomyopathy (DCM) is a cardiovascular complication with no known cure. In this study, we evaluated the combination of ultrasound-targeted microbubble destruction (UTMD) and cationic microbubbles (CMBs) for cardiac S-adenosyl homocysteine hydrolase (SAHH) gene transfection as potential DCM therapy. Models of high glucose/fat (HG/HF)-induced H9C2 cells and streptozotocin-induced DCM rats were established. Ultrasound-mediated SAHH delivery using CMBs was a safe and noninvasive approach for spatially localized drug administration both in vitro and in vivo ...
February 16, 2024: IScience
https://read.qxmd.com/read/38302774/renal-denervation-improves-cardiac-function-independently-of-afterload-and-restores-myocardial-norepinephrine-levels-in-a-rodent-heart-failure-model
#34
JOURNAL ARTICLE
Matúš Miklovič, Olga Gawryś, Zuzana Honetschlägerová, Petr Kala, Zuzana Husková, Soňa Kikerlová, Zdeňka Vaňourková, Šárka Jíchová, Alena Kvasilová, Misuzu Kitamoto, Hana Maxová, Guillermo Puertas-Frias, Tomáš Mráček, David Sedmera, Vojtěch Melenovský
Renal nerves play a critical role in cardiorenal interactions. Renal denervation (RDN) improved survival in some experimental heart failure (HF) models. It is not known whether these favorable effects are indirect, explainable by a decrease in vascular afterload, or diminished neurohumoral response in the kidneys, or whether RDN procedure per se has direct myocardial effects in the failing heart. To elucidate mechanisms how RDN affects failing heart, we studied load-independent indexes of ventricular function, gene markers of myocardial remodeling, and cardiac sympathetic signaling in HF, induced by chronic volume overload (aorto-caval fistula, ACF) of Ren2 transgenic rats...
February 2, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://read.qxmd.com/read/38293915/microrna-34a-dependent-attenuation-of-angiogenesis-in-right-ventricular-failure
#35
JOURNAL ARTICLE
Sushma Reddy, Dong-Qing Hu, Mingming Zhao, Shoko Ichimura, Elizabeth A Barnes, David N Cornfield, Miguel A Alejandre Alcázar, Edda Spiekerkoetter, Giovanni Fajardo, Daniel Bernstein
BACKGROUND: The right ventricle (RV) is at risk in patients with complex congenital heart disease involving right-sided obstructive lesions. We have shown that capillary rarefaction occurs early in the pressure-loaded RV. Here we test the hypothesis that microRNA (miR)-34a, which is induced in RV hypertrophy and RV failure (RVF), blocks the hypoxia-inducible factor-1α-vascular endothelial growth factor (VEGF) axis, leading to the attenuated angiogenic response and increased susceptibility to RV failure...
January 31, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38291755/inhibition-of-adenylyl-cyclase-8-prevents-the-upregulation-of-orai1-channel-which-improves-cardiac-function-after-myocardial-infarction
#36
JOURNAL ARTICLE
Débora Falcón, Eva M Calderón-Sánchez, Isabel Mayoral-González, Marta Martín-Bórnez, Alejandro Dominguez-Rodriguez, Encarnación Gutiérrez-Carretero, Antonio Ordóñez-Fernández, Juan Antonio Rosado, Tarik Smani
The upregulation of Orai1 and subsequent store-operated Ca2+ entry (SOCE) has been associated with adverse cardiac remodeling and heart failure (HF). However, the mechanism underlying Orai1 upregulation and its role in myocardial infarction remains unclear. Our study investigated the role of Orai1 in activating adenylyl cyclase 8 (AC8) and cAMP response element-binding protein (CREB), as well as its contribution to cardiac dysfunction induced by ischemia and reperfusion (I/R). We found that I/R evoked an increase in the expression of Orai1 and AC8 in rats' hearts, resulting in a substantial rise in diastolic Ca2+ concentration ([Ca2+ ]i ), and reduced ventricular contractions...
January 29, 2024: Molecular Therapy
https://read.qxmd.com/read/38290892/left-atrial-strain-a-memory-of-the-severity-of-atrial-myocardial-stress-in-atrial-fibrillation
#37
JOURNAL ARTICLE
Laurie Soulat-Dufour, Farid Ichou, Maharajah Ponnaiah, Sylvie Lang, Stéphane Ederhy, Saroumadi Adavane-Scheuble, Marion Chauvet-Droit, Elodie Capderou, Camille Arnaud, Wilfried Le Goff, Franck Boccara, Stéphane N Hatem, Ariel Cohen
BACKGROUND: Left atrial (LA) strain is a simple marker of LA function. The aim of the study was to evaluate the determinants of atrial cardiomyopathy in AF. METHODS: In this pilot study, we prospectively evaluated clinical, biological, metabolomic and echocardiographic parameters for 85 consecutive patients hospitalized for atrial fibrillation (AF) with restoration of sinus rhythm at 6 months. Eighty-one patients with an analysable LA strain at 6 months were divided into groups according to median reservoir strain:<23...
January 11, 2024: Archives of Cardiovascular Diseases
https://read.qxmd.com/read/38281374/predictors-of-cardiac-arrest-in-severe-accidental-hypothermia
#38
JOURNAL ARTICLE
Paweł Podsiadło, Tomáš Brožek, Martin Balik, Ewelina Nowak, Konrad Mendrala, Hubert Hymczak, Wojciech Dąbrowski, Bartosz Miazgowski, Aleksander Rutkiewicz, Marian Burysz, Anna Witt-Majchrzak, Tomasz Jędrzejczak, Rafał Podsiadło, Tomasz Darocha
STUDY OBJECTIVE: To indicate predictors of witnessed hypothermic cardiac arrest. METHODS: We conducted a retrospective analysis of 182 patients with severe accidental hypothermia (i.e., with core body temperature of ≤28 °C) who presented with preserved spontaneous circulation at first contact with medical services. We divided the study population into two groups: patients who suffered hypothermic cardiac arrest (HCA) at any time between encounter with medical service and restoration of normothermia, and those who did not sustain HCA...
January 21, 2024: American Journal of Emergency Medicine
https://read.qxmd.com/read/38277398/jagged-2-inhibition-attenuates-hypoxia-induced-mitochondrial-damage-and-pulmonary-hypertension-through-sirtuin-1-signaling
#39
JOURNAL ARTICLE
Hanhan Liu, Zhou Pan, Xiaofeng Wu, Cheng Gong, Junbo Hu
Notch pathway has played a significant role in the pathophysiology of pulmonary hypertension (PH). However, the role of Jagged 2 (Jag2), one ligand of Notch, remains to be elucidated.Therefore, determining the contribution of Jag2 to PH and its impact on pulmonary artery smooth muscle cells (PASMCs) was the aim of this investigation. Adeno-associated virus-mediated Jag2 inhibition was used to explore the role of Jag2 in peripheral pulmonary vascular remodeling assessed in a rat model of chronic hypoxia (10% O2, 4 weeks) induced pulmonary hypertension...
2024: PloS One
https://read.qxmd.com/read/38261663/systemic-hemodynamics-cardiac-mechanics-and-signaling-pathways-induced-by-extracorporeal-membrane-oxygenation-in-a-cardiogenic-shock-model
#40
JOURNAL ARTICLE
Antoine Beurton, Maxime Michot, François-Xavier Hérion, Mario Rienzo, Claire Oddos, Thierry Couffinhal, Julien Imbault, Alexandre Ouattara
Peripheral venoarterial extracorporeal membrane oxygenation (VA-ECMO) is increasingly being used in patients suffering from refractory cardiogenic shock (CS). Although considered life-saving, peripheral VA-ECMO may also be responsible for intracardiac hemodynamic changes, including left ventricular overload and dysfunction. Venoarterial extracorporeal membrane oxygenation may also increase myocardial wall stress and stroke work, possibly affecting the cellular cardioprotective and apoptosis signaling pathways, and thus the infarct size...
March 1, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
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