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Dominique Endres, Rick Dersch, Oliver Stich, Armin Buchwald, Evgeniy Perlov, Bernd Feige, Simon Maier, Andreas Riedel, Ludger Tebartz van Elst
INTRODUCTION: Vitamin D has many immunomodulatory, anti-inflammatory, and neuroprotective functions, and previous studies have demonstrated an association between vitamin D deficiency and neuropsychiatric disease. The aim of our study was to analyze the prevalence of vitamin D deficiency in a 1-year cohort of adult inpatients with schizophreniform and autism spectrum syndromes in a naturalistic inpatient setting in Germany. PARTICIPANTS AND METHODS: Our study was comprised of 60 adult schizophreniform and 23 adult high-functioning autism spectrum patients who were hospitalized between January and December of 2015...
2016: Frontiers in Psychiatry
André M Huss, Steffen Halbgebauer, Patrick Öckl, Corinna Trebst, Annette Spreer, Nadja Borisow, Andrea Harrer, Isabel Brecht, Bettina Balint, Oliver Stich, Sabine Schlegel, Nele Retzlaff, Alexander Winkelmann, Romy Roesler, Florian Lauda, Özlem Yildiz, Elke Voß, Rainer Muche, Sebastian Rauer, Florian Then Bergh, Markus Otto, Friedemann Paul, Brigitte Wildemann, Jörg Kraus, Klemens Ruprecht, Martin Stangel, Mathias Buttmann, Uwe K Zettl, Hayrettin Tumani
The majority of patients presenting with a first clinical symptom suggestive of multiple sclerosis (MS) do not fulfill the MRI criteria for dissemination in space and time according to the 2010 revision of the McDonald diagnostic criteria for MS and are thus classified as clinically isolated syndrome (CIS). To re-evaluate the utility of cerebrospinal fluid (CSF) analysis in the context of the revised McDonald criteria from 2010, we conducted a retrospective multicenter study aimed at determining the prevalence and predictive value of oligoclonal IgG bands (OCBs) in patients with CIS...
October 11, 2016: Journal of Neurology
Veronika Šrámková, Lenka Rossmeislová, Eva Krauzová, Jana Kračmerová, Michal Koc, Dominique Langin, Vladimír Štich, Michaela Šiklová
CONTEXT: Beneficial metabolic effects of calorie restriction found in the early stage of hypocalorie diets may be caused by the modulation of metabolic and endocrine function of adipose tissue. OBJECTIVE: To compare metabolic and inflammation-related characteristics of subcutaneous adipose tissue (SAAT) in the early (2 days) and later (28 days) phase of VLCD. Design, Setting, Intervention and Patients: 17 moderately obese premenopausal women followed 800 kcal/d VLCD for 28 days...
October 7, 2016: Journal of Clinical Endocrinology and Metabolism
Charles Mesnard, Laurence Beral, Rabih Hage, Harold Merle, Selim Farès, Thierry David
PURPOSE: To report a case series of post-phacoemulsification endophthalmitis despite antibiotic prophylaxis with an intracameral injection of a licensed cefuroxime formulation (Aprokam). SETTING: University Hospitals of Pointe-à-Pitre, Guadeloupe, and Fort-de-France, Martinique, French West Indies. DESIGN: Retrospective case series. METHODS: Patients who had cataract surgery with licensed cefuroxime prophylaxis between March 1, 2013, and July 31, 2015, and developed endophthalmitis were included...
September 2016: Journal of Cataract and Refractive Surgery
Fabian Bock, Gary Lu, Samer Srour, Sameh Gaballa, Heather Y Lin, Veerabhadran Baladandayuthapani, Medhavi Honhar, Maximilian Stich, Nina Das Shah, Qaiser Bashir, Krina Patel, Uday Popat, Chitra Hosing, Martin Korbling, Ruby Delgado, Gabriela Rondon, Jatin J Shah, Sheeba K Thomas, Elisabet E Manasanch, Berend Isermann, Robert Z Orlowski, Richard E Champlin, Muzaffar H Qazilbash
The gain/amplification of the CKS1B gene on chromosome 1q21 region is associated with a poor outcome in patients with multiple myeloma (MM). However, there are limited data on the outcome of patients with CKS1B amplification after a single high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HCT). We retrospectively evaluated the outcome of patients with CKS1B amplification who received an auto-HCT between June 2012 and July 2014 at our institution. We identified 58 patients with MM and CKS1B gene amplification detected by fluorescent in situ hybridization (FISH)...
September 13, 2016: Biology of Blood and Marrow Transplantation
Karl-Friedrich Kowalewski, Jonathan D Hendrie, Mona W Schmidt, Carly R Garrow, Thomas Bruckner, Tanja Proctor, Sai Paul, Davud Adigüzel, Sebastian Bodenstedt, Andreas Erben, Hannes Kenngott, Young Erben, Stefanie Speidel, Beat P Müller-Stich, Felix Nickel
INTRODUCTION: Training and assessment outside of the operating room is crucial for minimally invasive surgery due to steep learning curves. Thus, we have developed and validated the sensor- and expert model-based laparoscopic training system, the iSurgeon. MATERIALS: Participants of different experience levels (novice, intermediate, expert) performed four standardized laparoscopic knots. Instruments and surgeons' joint motions were tracked with an NDI Polaris camera and Microsoft Kinect v1...
September 7, 2016: Surgical Endoscopy
Mark C Petrie, Pardeep S Jhund, Lilin She, Christopher Adlbrecht, Torsten Doenst, Julio A Panza, James A Hill, Kerry L Lee, Jean L Rouleau, David L Prior, Imtiaz S Ali, Jyostna Maddury, Krzysztof S Golba, Harvey D White, Peter E Carson, Lukasz Chrzanowski, Alexander Romanov, Alan B Miller, Eric J Velazquez
BACKGROUND: Advancing age is associated with a greater prevalence of coronary artery disease in heart failure with reduced ejection fraction and with a higher risk of complications after coronary artery bypass grafting (CABG). Whether the efficacy of CABG compared with medical therapy (MED) in patients with heart failure caused by ischemic cardiomyopathy is the same in patients of different ages is unknown. METHODS: A total of 1212 patients (median follow-up, 9...
August 29, 2016: Circulation
Heribert Ludwig Stich, Riccardo N Caniato, Alexander Krämer, Bernhard Baune
OBJECTIVES: The aim of the study was to calculate the impact that the duration of attendance and the location of the kindergarten (rural versus urban) has on the prevalence of multiple delays in preschool children. METHODS: We analyzed data from 14,068 preschool children, over a period of 14 consecutive years (1997-2010) from the Bavarian Pre-School Morbidity Survey using software package SPSS 21.0. We assessed the incidence of multiple developmental impairments (twofold or above) in various developmental domains...
August 26, 2016: International Journal of Public Health
Michael Stich, Josep M Ribó, Donna G Blackmond, David Hochberg
We analyze a recent proposal for spontaneous mirror symmetry breaking based on the coupling of first-order enantioselective autocatalysis and direct production of the enantiomers that invokes a critical role for intrinsic reaction noise. For isolated systems, the racemic state is the unique stable outcome for both stochastic and deterministic dynamics when the system is in compliance with the constraints dictated by the thermodynamics of chemical reaction processes. In open systems, the racemic outcome also results for both stochastic and deterministic dynamics when driving the autocatalysis unidirectionally by external reagents...
August 21, 2016: Journal of Chemical Physics
Nickalaus L Gramze, Dipan J Shah
PURPOSE OF REVIEW: Cardiac MRI is unique amongst the cardiac imaging modalities in its ability to directly image myocardial fibrosis using late gadolinium enhancement techniques. The ability to identify not only the presence of fibrosis but also its pattern of distribution within the myocardium can aid in distinguishing between ischemic and nonischemic causes of left ventricular dysfunction, as well as provide valuable prognostic information for patients with various etiologies of heart failure...
September 2016: Current Opinion in Cardiology
Maximilian Stich, Lennard Ganss, Jens Puschhof, Elena-Sophie Prigge, Miriam Reuschenbach, Ana Guiterrez, Svetlana Vinokurova, Magnus von Knebel Doeberitz
High-risk human papillomaviruses (hr HPVs) may cause various human cancers and associated premalignant lesions. Transformation of the host cells is triggered by overexpression of the viral oncogenes E6 and E7 that deregulate the cell cycle and induce chromosomal instability. This process is accompanied by hypermethylation of distinct CpG sites resulting in silencing of tumor suppressor genes, inhibition of the viral E2 mediated control of E6 and E7 transcription as well as deregulated expression of host cell microRNAs...
July 16, 2016: Oncotarget
Clifton L Wagner, Lizhi Tao, Emily J Thompson, Troy A Stich, Jingdong Guo, James C Fettinger, Louise A Berben, R David Britt, Shigeru Nagase, Philip P Power
The synthesis of the first linear coordinated Cu(II) complex Cu{N(SiMe3 )Dipp}2 (1 Dipp=C6 H5 -2,6Pr(i) 2 ) and its Cu(I) counterpart [Cu{N(SiMe3 )Dipp}2 ](-) (2) is described. The formation of 1 proceeds through a dispersion force-driven disproportionation, and is the reaction product of a Cu(I) halide and LiN(SiMe3 )Dipp in a non-donor solvent. The synthesis of 2 is accomplished by preventing the disproportionation into 1 by using the complexing agent 15-crown-5. EPR spectroscopy of 1 provides the first detailed study of a two-coordinate transition-metal complex indicating strong covalency in the Cu-N bonds...
August 22, 2016: Angewandte Chemie
Wayne E Clarke, Erin E Higgins, Joerg Plieske, Ralf Wieseke, Christine Sidebottom, Yogendra Khedikar, Jacqueline Batley, Dave Edwards, Jinling Meng, Ruiyuan Li, Cynthia Taylor Lawley, Jérôme Pauquet, Benjamin Laga, Wing Cheung, Federico Iniguez-Luy, Emmanuelle Dyrszka, Stephen Rae, Benjamin Stich, Rod J Snowdon, Andrew G Sharpe, Martin W Ganal, Isobel A P Parkin
The Brassica napus Illumina array provides genome-wide markers linked to the available genome sequence, a significant tool for genetic analyses of the allotetraploid B. napus and its progenitor diploid genomes. A high-density single nucleotide polymorphism (SNP) Illumina Infinium array, containing 52,157 markers, was developed for the allotetraploid Brassica napus. A stringent selection process employing the short probe sequence for each SNP assay was used to limit the majority of the selected markers to those represented a minimum number of times across the highly replicated genome...
October 2016: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
B P Müller-Stich, G R Linke, M Wagner, D C Steinemann
The oncological equivalence of laparoscopic and open rectal cancer resection was evaluated in four multicenter randomized controlled trials. The COLOR II and the COREAN trials demonstrated oncological equivalence; however, the ACOSOG and the ALaCaRT studies came to a different conclusion. In the latter two studies a composite endpoint that assessed the quality of the mesorectal specimen, the completeness of tumor-free circumferential and distal resection margins was chosen. In both trials a higher success rate for open surgery was shown; nevertheless, the validity of this composite endpoint has not been proven and no conclusions on solid oncological endpoints can be drawn...
July 2016: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
Reinhard Klinkott, Venance Mushi, Gaudens Komba, Carsten Krüger, Andreas Schultz, August Stich, Ansgar Stüfe, Martin Weber, Stephan Ehrhardt
BACKGROUND: It is unclear whether algorithms with evidence-based interventions are used in a setting where the work load is high and qualified staff is scarce to identify neonates with life-threatening conditions. METHODS: The nurse-midwives' knowledge and opinion about the World Health Organization (WHO) guide on postpartum newborn care were assessed in a hospital in Tanzania before and after training. Their adherence to this guide was evaluated by analysing 100 neonatal records...
June 17, 2016: Journal of Tropical Pediatrics
Felix Nickel, Karl-Friedrich Kowalewski, Florian Rehberger, Jonathan David Hendrie, Benjamin Friedrich Berthold Mayer, Hannes Götz Kenngott, Vasile Bintintan, Georg Richard Linke, Lars Fischer, Beat Peter Müller-Stich
BACKGROUND: The pulsatile organ perfusion (POP) trainer provides training of minimally invasive surgery (MIS) with real instruments and cadaveric organs. It provides training of full procedures with simulation of bleeding. Although widely used, the face validity has not yet been evaluated. This study aimed to establish face validity of the POP trainer for laparoscopic cholecystectomy (LC) and its usefulness compared with other training modalities. MATERIALS AND METHODS: During MIS courses, the participants (n = 52) used the POP trainer to perform LC...
June 17, 2016: Surgical Endoscopy
Heribert Ludwig Stich, Riccardo Caniato, Alexander Krämer, Bernhard Baune
OBJECTIVES: The aim of this study was to identify the time trends of multiple developmental delays and to determine the strength of selected factors influencing preschool child's development. METHODS: We reviewed the records of 13,876 preschoolers in a district of Lower Bavaria to determine prevalence and time trends of combined developmental delays from 1997 to 2010. The effect of age, sex and nationality on development was estimated by using regression models...
June 17, 2016: International Journal of Public Health
Aditya Bhat, Gary C H Gan, Timothy C Tan, Chijen Hsu, Alan Robert Denniss
Ischaemic left ventricular (LV) dysfunction can arise from myocardial stunning, hibernation, or necrosis. Imaging modalities have become front-line methods in the assessment of viable myocardial tissue, with the aim to stratify patients into optimal treatment pathways. Initial studies, although favorable, lacked sufficient power and sample size to provide conclusive outcomes of viability assessment. Recent trials, including the STICH and HEART studies, have failed to confer prognostic benefits of revascularisation therapy over standard medical management in ischaemic cardiomyopathy...
2016: Cardiology Research and Practice
Michael Stich, Amit K Chattopadhyay
In oscillatory reaction-diffusion systems, time-delay feedback can lead to the instability of uniform oscillations with respect to formation of standing waves. Here, we investigate how the presence of additive, Gaussian white noise can induce the appearance of standing waves. Combining analytical solutions of the model with spatiotemporal simulations, we find that noise can promote standing waves in regimes where the deterministic uniform oscillatory modes are stabilized. As the deterministic phase boundary is approached, the spatiotemporal correlations become stronger, such that even small noise can induce standing waves in this parameter regime...
May 2016: Physical Review. E
Michael Schwameis, Bernhard Roppenser, Christa Firbas, Corina S Gruener, Nina Model, Norbert Stich, Andreas Roetzer, Nina Buchtele, Bernd Jilma, Martha M Eibl
BACKGROUND: Staphylococcal toxic shock syndrome is a superantigen-driven potentially life-threatening disease affecting mainly young and otherwise healthy individuals. Currently, no specific treatment or preventive measure is available. We aimed to assess the safety, tolerability, and immunogenicity of a recombinant detoxified toxic shock syndrome toxin-1 variant (rTSST-1v) vaccine in adult volunteers. METHODS: In this randomised, double-blind, adjuvant-controlled, dose-escalation first-in-human trial, healthy adults aged 18-64 years were enrolled from the Medical University of Vienna, Austria...
September 2016: Lancet Infectious Diseases
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