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https://www.readbyqxmd.com/read/29155164/a-new-promising-candidate-to-overcome-drug-resistant-herpes-simplex-virus-infections
#1
Elisabeth Zinser, Adalbert Krawczyk, Petra Mühl-Zürbes, Ulrich Aufderhorst, Lena Stich, Mirko Zaja, Stefan Strobl, Alexander Steinkasserer, Christiane Silke Heilingloh
Infections with Herpes simplex viruses (HSV) belong to the most common human diseases worldwide, resulting in symptoms ranging from painful, but commonly self-limiting lesions of the orofacial or genital tract to severe infections of the eye or life-threatening generalized infections. Frequent HSV-reactivations at the eye may lead to the development of herpetic stromal keratitis, which is one of the major causes of infectious blindness in developed countries. The vast majority of life-threatening generalized infections occur in immunocompromised individuals, such as transplant recipients or patients suffering from advanced human immunodeficiency virus (HIV) infection with concurrent HSV-reactivation...
November 15, 2017: Antiviral Research
https://www.readbyqxmd.com/read/29143551/independent-validation-of-the-icu-requirement-score-in-a-cohort-of-acutely-poisoned-adults
#2
Regina Böll, Katrin Romanek, Sabrina Schmoll, Raphael Stich, Armin Ott, Jochen Stenzel, Stefanie Geith, Florian Eyer, Christian Rabe
OBJECTIVE: To independently validate the predictive value of the intensive care requirement score (IRS) in unselected poisoned patients. DESIGN: Retrospective chart review. PATIENTS AND METHODS: Five hundred and seventeen out of 585 admissions for acute intoxications could be analyzed. Eleven were excluded for a condition already requiring intensive care unit (ICU) support at admission (e.g., preclinical intubation). A further 57 admissions were excluded due to missing data...
November 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/29141137/wafer-scale-growth-and-transfer-of-highly-oriented-monolayer-mos2-continuous-films
#3
Hua Yu, Mengzhou Liao, Wenjuan Zhao, Guodong Liu, X J Zhou, Zheng Wei, Xiaozhi Xu, Kaihui Liu, Zonghai Hu, Ke Deng, Shuyun Zhou, Jin-An Shi, Lin Gu, Cheng Shen, Tingting Zhang, Luojun Du, Li Xie, Jianqi Zhu, Wei Chen, Rong Yang, Dongxia Shi, Guangyu Zhang
Large scale epitaxial growth and transfer of monolayer MoS2 has attracted great attention in recent years. Here, we report the wafer-scale epitaxial growth of highly oriented continuous and uniform monolayer MoS2 films on single-crystalline sapphire wafers by chemical vapor deposition (CVD) method. The epitaxial film is of high quality and stiched by many 0°, 60° domains and 60°-domain boundaries. Moreover, such wafer-scale monolayer MoS2 films can be transferred and stacked by a simple stamp-transfer process and the substrate is reusable for subsequent growth...
November 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/29134318/the-impact-of-different-peripheral-suture-techniques-on-the-biomechanical-stability-in-flexor-tendon-repair
#4
B Wieskötter, M Herbort, M Langer, M J Raschke, D Wähnert
PURPOSE: Flexor tendon repair consists of circumferential peripheral sutures in combination with core sutures to avoid fraying and reduces the exposure of suture material on tendon surface. The peripheral suture adds up to a tenfold increase of the biomechanical stability compared to the core suture alone. The purpose of our study was to determine the most favourable peripheral repair technique for tendon repair. METHODS: Seventy-two porcine flexor tendons underwent standardized tenotomy and repair using one of the following six methods (n = 12): simple-running (SR), simple-locking (SL), Halsted-mattress (HM), lin-locking (LL), Lembert-mattress (LM), and Silfverskiöld cross-stich (SCS) suture technique...
November 13, 2017: Archives of Orthopaedic and Trauma Surgery
https://www.readbyqxmd.com/read/29133151/laparoscopic-management-of-a-rudimentary-uterine-horn
#5
Emilie Faller, Jean Jacques Baldauf, François Becmeur, Anne Lehn, Cherif Youssef Akladios, Lise Lecointre
STUDY OBJECTIVE: To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl. DESIGN: A step-by-step explanation of the surgery using video (instructive video), approved the local institutional Review Board. SETTING: A university hospital, University Hospital of Strasbourg, France. PATIENT: A 12-year-old girl with a uterine rudimentary horn. INTERVENTION: We describe the case of a 12 years old girl who had no medical history...
November 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29130691/insertion-of-a-transient-tin-nitride-into-carbon-carbon-and-boron-carbon-bonds
#6
Shuai Wang, Lizhi Tao, Troy A Stich, Marilyn M Olmstead, R David Britt, Philip P Power
A simple exchange reaction between [Ar(iPr4)Sn(μ-Cl)]2 (1) and sodium azide afforded the doubly bridged Sn(II) azide, [Ar(iPr4)Sn(μ-N3)]2 (2) (Ar(iPr4) = C6H3-2,6(C6H3-2,6-(i)Pr2)2) in 85% yield. Photolysis of a diethyl ether solution of 2 for ca. 16 h yielded an azepinyl-substituted insertion product, [C6H3-2-(C6H3-2,6-(i)Pr2)-6-(C6H3N-3,7-(i)Pr2)Sn]2 (3). The reaction of the Lewis acid, B(C6F5)3 (BCF), or the Lewis base, pyridine, with 2 dissociates the dimer to afford the corresponding complexed monomeric Sn(II) azide, Ar(iPr4)SnN3BCF (4) in which BCF coordinates the α-nitrogen, or Ar(iPr4)Sn(pyridine)N3 (6) in which pyridine coordinates to the tin atom...
November 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29123489/plasmapheresis-responsive-rapid-onset-dementia-with-predominantly-frontal-dysfunction-in-the-context-of-hashimoto-s-encephalopathy
#7
Dominique Endres, Magnus S Vry, Petra Dykierek, Anne N Riering, Eva Lüngen, Oliver Stich, Rick Dersch, Nils Venhoff, Daniel Erny, Irina Mader, Philipp T Meyer, Ludger Tebartz van Elst
Background: Hashimoto's encephalopathy (HE) is a rare immunological neuropsychiatric disorder characterized by increased antithyroid antibodies and mixed neurological and psychiatric symptoms. HE has been previously discussed as a differential diagnosis for rapid progressive dementia. However, most of these patients suffered from additional neurological symptoms, like ataxia or seizures. Case presentation: Here, we present the case of a 59-year-old female patient suffering rapid onset dementia with salient frontal executive dysfunction...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/29119336/bariatric-surgery-as-an-efficient-treatment-for-non-alcoholic-fatty-liver-disease-in-a-prospective-study-with-1-year-follow-up-bariscan-study
#8
Felix Nickel, Christian Tapking, Laura Benner, Janina Sollors, Adrian T Billeter, Hannes G Kenngott, Loay Bokhary, Mathias Schmid, Moritz von Frankenberg, Lars Fischer, Sebastian Mueller, Beat P Müller-Stich
BACKGROUND: Bariatric surgery gains attention as a potential treatment for non-alcoholic fatty liver disease (NAFLD). The present study aimed to evaluate improvement of NAFLD after the two most common bariatric procedures with validated non-invasive instruments. MATERIAL AND METHODS: N = 100 patients scheduled for laparoscopic sleeve gastrectomy (LSG) or Roux-en-Y gastric bypass (RYGB) were included. NAFLD was evaluated preoperatively and postoperatively with liver stiffness measurement by transient elastography and laboratory-based fibrosis scores...
November 9, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29097746/quality-of-medical-therapy-in-heart-failure-patients-undergoing-elective-revascularisation-a-protective-effect-of-disease-modifying-therapy-at-discharge
#9
Raphael Wurm, Martin Huelsmann, Marius Hienert, Veronika Seidl, Dominik Wiedemann, Guenther Laufer, Alfred Kocher, Christopher Adlbrecht, Martin Andreas
The STICH(-ES) trial showed that coronary artery bypass grafting was superior to medical therapy alone in treating ischemic heart failure. However, dosages of disease modifying drugs were not reported. We included 128 (84% male, mean age 66 ± 11 years) consecutive patients with ischemic heart failure and an ejection fraction ≤35% undergoing isolated elective coronary artery bypass grafting. We defined optimal medical therapy (OMT) as prescription of ≥50% dosages of guideline recommended medications (i...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29083915/optical-gaps-in-pristine-and-heavily-doped-silicon-nanocrystals-dft-versus-quantum-monte-carlo-benchmarks
#10
R Derian, K Tokár, B Somogyi, Á Gali, I Štich
We present a time-dependent density functional theory (TDDFT) study of the optical gaps of light-emitting nanomaterials, namely, pristine and heavily B- and P-codoped silicon crystalline nanoparticles. Twenty DFT exchange-correlation functionals sampled from the best currently available inventory such as hybrids and range-separated hybrids are benchmarked against ultra-accurate quantum Monte Carlo results on small model Si nanocrystals. Overall, the range-separated hybrids are found to perform best. The quality of the DFT gaps is correlated with the deviation from Koopmans' theorem as a possible quality guide...
November 8, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29031214/land-use-regression-models-for-the-oxidative-potential-of-fine-particles-pm2-5-in-five-european-areas
#11
John Gulliver, David Morley, Chrissi Dunster, Adrienne McCrea, Erik van Nunen, Ming-Yi Tsai, Nicoltae Probst-Hensch, Marloes Eeftens, Medea Imboden, Regina Ducret-Stich, Alessio Naccarati, Claudia Galassi, Andrea Ranzi, Mark Nieuwenhuijsen, Ariadna Curto, David Donaire-Gonzalez, Marta Cirach, Roel Vermeulen, Paolo Vineis, Gerard Hoek, Frank J Kelly
Oxidative potential (OP) of particulate matter (PM) is proposed as a biologically-relevant exposure metric for studies of air pollution and health. We aimed to evaluate the spatial variability of the OP of measured PM2.5 using ascorbate (AA) and (reduced) glutathione (GSH), and develop land use regression (LUR) models to explain this spatial variability. We estimated annual average values (m(-3)) of OP(AA) and OP(GSH) for five areas (Basel, CH; Catalonia, ES; London-Oxford, UK (no OP(GSH)); the Netherlands; and Turin, IT) using PM2...
October 12, 2017: Environmental Research
https://www.readbyqxmd.com/read/28992657/-competing-validity-of-developmental-diagnostic-in-school-entry-examination-results-of-a-census-in-an-upper-bavarian-district
#12
Heribert Stich, Kristin Maria Schlinkmann, Rafael Mikolajczyk
Aim of the study Evaluation of the concurrent validity of a modified Bavarian model (BM) compared to the social-paediatric screening of developmental status for school entry (SOPESS) as a reference tool. Methods A total of 407 preschoolers to be enrolled for the school year 2015 in an Upper Bavarian District were examined by BM and SOPESS. As a measure of the concurrent validity, the Kappa by Cohen (ĸ) was used. Results The agreement of both instruments was moderate and was less pronounced for single dimensions than globally...
October 9, 2017: Das Gesundheitswesen
https://www.readbyqxmd.com/read/28920669/in-situ-studies-of-solid-electrolyte-interphase-sei-formation-on-crystalline-carbon-surfaces-by-neutron-reflectometry-and-atomic-force-microscopy
#13
Miriam Steinhauer, Michael Stich, Mario Kurniawan, Beatrix-Kamelia Seidlhofer, Marcus Trapp, Andreas Bund, Norbert Wagner, K Andreas Friedrich
The solid electrolyte interphase (SEI) is a complex and fragile passivation layer with crucial importance for the functionality of lithium-ion batteries. Due to its fragility and reactivity, the use of in situ techniques is preferable for the determination of the SEI's true structure and morphology during its formation. In this study, we use in situ neutron reflectometry (NR) and in situ atomic force microscopy (AFM) to investigate the SEI formation on a carbon surface. It was found that a lithium-rich adsorption layer is already present at the open circuit voltage on the carbon sample surface and that the first decomposition products start to deposit close to this potential...
October 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28881717/5-aza-2-deoxycytidine-dac-treatment-downregulates-the-hpv-e6-and-e7-oncogene-expression-and-blocks-neoplastic-growth-of-hpv-associated-cancer-cells
#14
Maximilian Stich, Lennard Ganss, Jens Puschhof, Elena-Sophie Prigge, Miriam Reuschenbach, Ana Guiterrez, Svetlana Vinokurova, Magnus von Knebel Doeberitz
High-risk human papillomaviruses (hr HPVs) may cause various human cancers and associated premalignant lesions. Transformation of the host cells is triggered by overexpression of the viral oncogenes E6 and E7 that deregulate the cell cycle and induce chromosomal instability. This process is accompanied by hypermethylation of distinct CpG sites resulting in silencing of tumor suppressor genes, inhibition of the viral E2 mediated control of E6 and E7 transcription as well as deregulated expression of host cell microRNAs...
August 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28842761/inflammatory-response-and-peritoneal-contamination-after-transrectal-natural-orifice-specimen-extraction-nose-versus-mini-laparotomy-a-porcine-in-vivo-study
#15
Jonas D Senft, Tilman Dröscher, Philip Gath, Philip C Müller, Adrian Billeter, Beat P Müller-Stich, Georg R Linke
BACKGROUND: Transrectal natural orifice specimen extraction (NOSE) avoids abdominal organ retrieval during laparoscopic procedures and may reduce surgical trauma. However, this has not been proven clinically and transrectal peritoneal contamination is feared to cause infectious complications. This experimental study was designed to evaluate inflammatory response and peritoneal contamination after transrectal NOSE versus mini-laparotomy. METHODS: 24 German Landrace pigs underwent transrectal NOSE (N = 12) or mini-laparotomy (N = 12) for standardized extraction of water-instilled balloon...
August 25, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28840317/impact-of-visual-spatial-ability-on-laparoscopic-camera-navigation-training
#16
Paul J Roch, Henriette M Rangnick, Julia A Brzoska, Laura Benner, Karl-Friedrich Kowalewski, Philip C Müller, Hannes G Kenngott, Beat-Peter Müller-Stich, Felix Nickel
BACKGROUND: Technical limitations of minimally invasive surgery challenge both surgeons and camera assistants. Current research indicates that visual-spatial ability (VSA) has impact on learning of laparoscopic camera navigation (LCN). However, it remains unclear if complexity of LCN tasks influences the impact of VSA. The aim of this study was to examine the influence of VSA on LCN training within tasks of different complexity levels. METHODS: The present study was conducted as a monocentric prospective trial...
August 24, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28838632/the-triangle-operation-radical-surgery-after-neoadjuvant-treatment-for-advanced-pancreatic-cancer-a-single-arm-observational-study
#17
Thilo Hackert, Oliver Strobel, Christoph W Michalski, André L Mihaljevic, Arianeb Mehrabi, Beat Müller-Stich, Christoph Berchtold, Alexis Ulrich, Markus W Büchler
BACKGROUND: Neoadjuvant therapy is an important strategy for locally advanced pancreatic cancer (PDAC) as resection rates increase with modern chemotherapy regimens even in patients with arterial tumor encasement. The aim of this study is the description of technique and initial outcomes of a new type of radical and arterial-sparing resection after neoadjuvant treatment for locally advanced PDAC. METHODS: The surgical technique and perioperative results of a new type of operation are described, comprising radical tumor removal by sharp dissection along the celiac axis and the superior mesenteric artery with complete dissection of all soft tissue between both - arteries and superior mesenteric/portal vein (TRIANGLE operation)...
November 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28834793/surgical-ventricular-remodeling-should-we-stich-or-not
#18
Vivek Rao
PURPOSE OF REVIEW: The surgical management of patients with ischemic cardiomyopathy, especially those with left ventricular ejection fractions less than 20% has historically been controversial. The original trials of surgical revascularization versus medical therapy intentionally excluded those patients with an ejection fraction less than 35%. The significant advances in medical therapy for heart failure over the past 30 years (β-blockade, angiotensin converting enzyme inhibitors, internal cardiac defibrillator and so on) also mandated a reevaluation of the potential benefits of surgical revascularization in this high-risk subset...
November 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28801721/surgery-is-essential-in-squamous-cell-cancer-of-the-rectum
#19
D C Steinemann, P C Müller, A T Billeter, T Bruckner, A Ulrich, B P Müller-Stich
PURPOSE: Squamous cell cancer (SCC) is a rare histological subtype of rectal cancer. It is unclear whether SCC should be treated by multimodal therapy, including surgery, or by chemoradiation alone. The objective of the study was to define an optimal treatment strategy. METHODS: Patients with rectal cancer and SCC histology were identified in the Surveillance Epidemiology and End Results Database between 1990 and 2013. According to treatment, three groups were defined: radiotherapy and surgery (RT/SX), radiotherapy (RT), and surgery (SX)...
November 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28801083/halsted-s-see-one-do-one-and-teach-one-versus-peyton-s-four-step-approach-a-randomized-trial-for-training-of-laparoscopic-suturing-and-knot-tying
#20
Philipp Romero, Patrick Gu Nther, Karl-Friedrich Kowalewski, Mirco Friedrich, Mona W Schmidt, Sarah M Trent, Javier R De La Garza, Beat P Mu Ller-Stich, Felix Nickel
BACKGROUND: This study aimed to compare the effectiveness of Halsted's method "see one, do one, and teach one" with Peyton's Four-Step Approach for teaching intracorporal suturing and knot tying (ICKT). METHODS: Laparoscopically naïve medical students (n = 60) were randomized to teaching of ICKT with either Halsted's (n = 30) or Peyton's method (n = 30) for 60 minutes. Each student's first 3 and final sutures were evaluated using Objective Structured Assessment of Technical Skills (OSATS), procedural implementation, knot quality, total time, and suture placement accuracy...
August 8, 2017: Journal of Surgical Education
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