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Miriam Fritz, Benjamin Berger, Mathias Schemmerer, Dominique Endres, Jürgen J Wenzel, Oliver Stich, Marcus Panning
There is growing evidence that hepatitis E virus (HEV) infection can present with extrahepatic manifestations including neurological disorders. Among these, neuralgic amyotrophy (NA) has been reported to occur in some industrialized countries. We investigated 35 patients with NA and a control group for markers of HEV infection. Acute HEV infection was found in NA patients only and was associated with an inflammatory response in the central nervous system. Shedding of HEV RNA into the cerebrospinal fluid and intrathecal production of anti-HEV IgM occurred in one patient suggesting that HEV is neurotropic...
March 14, 2018: Journal of Infectious Diseases
Christian Haselmair-Gosch, Silvija Miosic, Daria Nitarska, Barbara L Roth, Benjamin Walliser, Renate Paltram, Rares C Lucaciu, Lukas Eidenberger, Thomas Rattei, Klaus Olbricht, Karl Stich, Heidi Halbwirth
A recall campaign for commercial, orange flowering petunia varieties in spring 2017 caused economic losses worldwide. The orange varieties were identified as undeclared genetically engineered (GE)-plants, harboring a maize dihydroflavonol 4-reductase ( DFR, A 1 ), which was used in former scientific transgenic breeding attempts to enable formation of orange pelargonidin derivatives from the precursor dihydrokaempferol (DHK) in petunia. How and when the A 1 cDNA entered the commercial breeding process is unclear...
2018: Frontiers in Plant Science
Tilman Hottenrott, Elisabeth Schorb, Kristina Fritsch, Rick Dersch, Benjamin Berger, Daniela Huzly, Sebastian Rauer, Ludger Tebartz van Elst, Dominique Endres, Oliver Stich
Some patients with primary central nervous system lymphoma (PCNSL) may initially present with similar clinical, magnetic resonance imaging, and routine cerebrospinal fluid (CSF) findings as those observed in multiple sclerosis (MS). The MRZ reaction (MRZR), composed of the three respective antibody indices (AIs) against measles, rubella, and varicella zoster virus, appears to be the most specific CSF marker for MS. This study aimed to determine whether a positive MRZR and other routine CSF markers help differentiate between MS and PCNSL...
March 6, 2018: Journal of Neurology
Maximilian Gertler, Sven Loik, Christian Kleine, Alexa Matuschek, Norbert Gresser, Mario di Gennaro, Andreas Fabricius, Thomas Kratz, August Stich, Joost Butenop
BACKGROUND: In September 2014, the German government mandated the German Red Cross (GRC) and the German Armed Forces to support the international efforts to stop the epidemic of Ebola virus disease (EVD) in West-Africa. The GRC requested specific training from the Medical Mission Institute Wuerzburg (MI). OBJECTIVES: We describe and discuss the development, strategy, results, and evaluation of the program to formulate conclusions and recommendations for similar emergencies...
February 26, 2018: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
Manuel Stich, Tobias Wech, Anne Slawig, Ralf Ringler, Andrew Dewdney, Andreas Greiser, Gudrun Ruyters, Thorsten A Bley, Herbert Köstler
PURPOSE: The gradient system transfer function (GSTF) has been used to describe the distorted k-space trajectory for image reconstruction. The purpose of this work was to use the GSTF to determine the pre-emphasis for an undistorted gradient output and intended k-space trajectory. METHODS: The GSTF of the MR system was determined using only standard MR hardware without special equipment such as field probes or a field camera. The GSTF was used for trajectory prediction in image reconstruction and for a gradient waveform pre-emphasis...
February 25, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Adrian T Billeter, Beat P Müller-Stich
No abstract text is available yet for this article.
February 1, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Gudrun Kreye, Eva-Katharina Masel, Klaus Hackner, Beate Stich, Friedemann Nauck
Recently, the use of methadone in cancer patients has increased due to in vitro studies indicating that methadone is capable of inducing cell death. However, thus far there are no relevant clinical studies indicating that the use of methadone can prolong survival in cancer patients. Based on low-quality evidence, methadone is a drug that has similar analgesic benefits to morphine and has a role in the management of cancer pain in adults. Other opioids such as morphine, hydromorphone, and fentanyl are easier to manage but may be more expensive than methadone in many economies...
February 19, 2018: Wiener Medizinische Wochenschrift
Ileana L Piña, Qi Zheng, Lilin She, Hanna Szwed, Irene M Lang, Pedro S Farsky, Serenella Castelvecchio, Jolanta Biernat, Alexandros Paraforos, Dragana Kosevic, Liliana E Favaloro, José C Nicolau, Padmini Varadarajan, Eric J Velazquez, Ramdas G Pai, Nicole Cyrille, Kerry L Lee, Patrice Desvigne-Nickens
BACKGROUND: Female sex is conventionally considered a risk factor for coronary artery bypass grafting (CABG) and has been included as a poor prognostic factor in multiple cardiac operative risk evaluation scores. We aimed to investigate the association of sex and the long-term benefit of CABG in patients with ischemic left ventricular dysfunction enrolled in the prospective STICH trial (Surgical Treatment for Ischemic Heart Failure Study). METHODS: The STICH trial randomized 1212 patients (148 [12%] women and 1064 [88%] men) with coronary artery disease and left ventricular ejection fraction ≤35% to CABG+medical therapy (MED) versus MED alone...
February 20, 2018: Circulation
Grigol Tediashvili, Dong Wang, Hermann Reichenspurner, Tobias Deuse, Sonja Schrepfer
The use of animal models is essential for a better understanding of MH, one major cause for arterial stenosis.In this article, we demonstrate a murine balloon denudation model, which is comparable with established vessel injury models in large animals. The aorta denudation model with balloon catheters mimics the clinical setting and leads to comparable pathobiological and physiological changes. Briefly, after performing a horizontal incision in the aorta abdominalis, a balloon catheter will be inserted into the vessel, inflated, and introduced retrogradely...
February 7, 2018: Journal of Visualized Experiments: JoVE
K F Kowalewski, C R Garrow, T Proctor, A A Preukschas, M Friedrich, P C Müller, H G Kenngott, L Fischer, B P Müller-Stich, F Nickel
BACKGROUND: Multiple training modalities for laparoscopy have different advantages, but little research has been conducted on the benefit of a training program that includes multiple different training methods compared to one method only. This study aimed to evaluate benefits of a combined multi-modality training program for surgical residents. METHODS: Laparoscopic cholecystectomy (LC) was performed on a porcine liver as the pre-test. Randomization was stratified for experience to the multi-modality Training group (12 h of training on Virtual Reality (VR) and box trainer) or Control group (no training)...
February 12, 2018: Surgical Endoscopy
Karl-Friedrich Kowalewski, Mona W Schmidt, Tanja Proctor, Moritz Pohl, Erica Wennberg, Emir Karadza, Philipp Romero, Hannes G Kenngott, Beat P Müller-Stich, Felix Nickel
BACKGROUND: There is limited evidence on the transferability of conventional laparoscopic and open surgical skills to robotic-assisted surgery. The primary aim of this study was to evaluate the transferability of expertise in conventional laparoscopy and open surgery to robotic-assisted surgery using the da Vinci Skills Simulator (dVSS). Secondary aims included evaluating the influence of individual participants' characteristics. METHODS: Participants performed four tasks on the dVSS: Peg Board 1 (PB), Pick and Place (PP), Thread the Rings (TR), and Suture Sponge 1 (SS)...
February 12, 2018: Surgical Endoscopy
Daniel C Steinemann, Philip C Müller, Martin Apitz, Felix Nickel, Hannes G Kenngott, Beat P Müller-Stich, Georg R Linke
BACKGROUND: Three-dimensional printing (3DP) has become popular for development of anatomic models, preoperative planning, and production of tailored implants. A novel laparoscopic, transgastric procedure for distal esophageal mucosectomy was developed. During this procedure, a space holder had to be introduced into the distal esophagus for exposure during suturing. The production process and evaluation of a 3DP space holder are described herein. MATERIALS AND METHODS: Computer-aided design software was used to develop models printed from polylactic acid...
March 2018: Journal of Surgical Research
Nadia Bouabdallaoui, Susanna R Stevens, Torsten Doenst, Krzysztof Wrobel, Denis Bouchard, Marek A Deja, Robert E Michler, Yeow Leng Chua, Renato A K Kalil, Craig H Selzman, Richard C Daly, Benjamin Sun, Ljubomir T Djokovic, George Sopko, Eric J Velazquez, Jean L Rouleau, Kerry L Lee, Hussein R Al-Khalidi
OBJECTIVE: The authors aimed to assess determinants of intubation time and evaluate its impact on 30-day and 1-year postoperative survival in Surgical Treatment for Ischemic Heart Failure (STICH) trial patients. DESIGN, SETTING, PARTICIPANTS, AND INTERVENTIONS: A multivariable Cox proportional hazards model was used among the 1,446 surgical patients from the STICH trial who survived 36 hours after operation, in order to identify perioperative factors associated with 30-day and 1-year postoperative mortality...
December 23, 2017: Journal of Cardiothoracic and Vascular Anesthesia
Ian Barr, Troy A Stich, Anthony S Gizzi, Tyler L Grove, Jeffrey B Bonanno, John A Latham, Tyler Chung, Carrie M Wilmot, R David Britt, Steven C Almo, Judith P Klinman
The Radical SAM (RS) enzyme PqqE catalyzes the first step in the biosynthesis of the bacterial cofactor pyrroloquinoline quinone, forming a new carbon-carbon bond between two side chains within the ribosomally synthesized peptide substrate PqqA. In addition to the active site RS 4Fe-4S cluster, PqqE is predicted to have two auxiliary Fe-S clusters, like the other members of the SPASM domain family. Here we identify these sites and examine their structure using a combination of X-ray crystallography and Mössbauer and electron paramagnetic resonance (EPR) spectroscopies...
February 6, 2018: Biochemistry
A T Billeter, K M Scheurlen, P Probst, S Eichel, F Nickel, S Kopf, L Fischer, M K Diener, P P Nawroth, B P Müller-Stich
BACKGROUND: This study aimed to examine the effect of metabolic surgery on pre-existing and future microvascular complications in patients with type 2 diabetes mellitus (T2DM) in comparison with medical treatment. Although metabolic surgery is the most effective treatment for obese patients with T2DM regarding glycaemic control, it is unclear whether the incidence or severity of microvascular complications is reduced. METHODS: A systematic literature search was performed in MEDLINE, Embase, Web of Science and the Cochrane Central Register of Controlled Trials (CENTRAL) with no language restrictions, looking for RCTs, case-control trials and cohort studies that assessed the effect of metabolic surgery on the incidence of microvascular diabetic complications compared with medical treatment as control...
February 2018: British Journal of Surgery
Tilman Hottenrott, Rick Dersch, Benjamin Berger, Dominique Endres, Daniela Huzly, Jens Thiel, Sebastian Rauer, Oliver Stich, Ulrich Salzer, Nils Venhoff
BACKGROUND: Some rheumatologic disorders may initially manifest with central nervous system (CNS) affection, mimicking the clinical, magnetic resonance imaging, and cerebrospinal fluid findings of multiple sclerosis (MS). The MRZ reaction (MRZR), composed of the three respective antibody indices (AIs) against measles, rubella, and varicella zoster virus, has been found positive frequently in MS patients. However, it is unclear whether the MRZR is helpful to distinguish rheumatologic disorders with CNS involvement (RDwCNS) from MS...
January 31, 2018: BMC Neurology
Thomas Wehrum, Lena-Alexandra Beume, Oliver Stich, Irina Mader, Mathias Mäurer, Adam Czaplinski, Cornelius Weiller, Sebastian Rauer
OBJECTIVE: To report 3 patients with multiple sclerosis showing severe activation of disease during immunotherapy with alemtuzumab. METHODS: Retrospective case series. RESULTS: Patient 1, a 21-year-old woman, developed severe cognitive impairment, sight deterioration, severe gait ataxia, urinary retention, and extensive progression of cerebral lesion load, including new lesions that exhibited gadolinium ring enhancement and dominance of CD19/20-positive B lymphocytes, 6 months after induction of alemtuzumab...
February 13, 2018: Neurology
Giuseppe Santarpino, Marcello Melone, Luigi Specchia, Antonio Albano, Anna Nicoletti, Renato Gregorini
No abstract text is available yet for this article.
January 9, 2018: Journal of Cardiovascular Surgery
Mark D Haley, Barbara A Gregson, W Andrew Mould, Daniel F Hanley, Alexander David Mendelow
BACKGROUND AND PURPOSE: The ABC/2 method for calculating intracerebral hemorrhage (ICH) volume has been well validated. However, the formula, derived from the volume of an ellipse, assumes the shape of ICH is elliptical. We sought to compare the agreement of the ABC/2 formula with other methods through retrospective analysis of a selection of the STICH II cohort (Early Surgery Versus Initial Conservative Treatment in Patients With Spontaneous Supratentorial Lobar Intracerebral Haematomas)...
February 2018: Stroke; a Journal of Cerebral Circulation
David A Marchiori, Paul H Oyala, Richard J Debus, Troy A Stich, R David Britt
The Mn4CaO5 oxygen-evolving complex (OEC) of photosystem II catalyzes the light-driven oxidation of two substrate waters to molecular oxygen. An ELDOR-detected NMR and computational study has indicated that ammonia, a substrate analogue, binds as a terminal ligand to the Mn4A ion trans to the O5 μ4 oxido bridge.[Perez Navarro M., et al., Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 15561-15566] A subsequent electron spin echo envelope modulation (ESEEM) study confirmed this result and showed that ammonia hydrogen bonds to the carboxylate sidechain of D1-Asp61...
January 5, 2018: Journal of Physical Chemistry. B
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