Alexis Dissard, Nathalie P Dang, Isabelle Barthelemy, Candice Delbet, Mathilde Puechmaille, Arnaud Depeyre, Bruno Pereira, Fanny Martin, Florent Guillemin, Julian Biau, Sonia Mirafzal, Thierry Mom, Laurent Gilain, Nicolas Saroul
OBJECTIVES/HYPOTHESIS: PENTOCLO treatment, associating pentoxifylline, tocopherol, and clodronate, resolves radiation-induced fibrosis. The main aim of the present study was to prospectively assess efficacy in mandibular osteoradionecrosis (ORN). STUDY DESIGN: Prospective cohort study. METHODS: Twenty-seven patients with mandibular ORN were included in the Pentoclauvergne Study between January 2014 and February 2016. After an initial 28-day phase of antibiotic, antifungal, and corticosteroid therapy, they received the PENTOCLO association daily until cure or a maximum of 24 months...
November 2020: Laryngoscope