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https://www.readbyqxmd.com/read/29787881/a-long-term-follow-up-after-radiosurgery-of-papillary-tumour-of-the-pineal-region-ptpr-two-cases-report-and-review-of-the-literature
#1
Cecilia Fernández-Mateos, Roberto Martinez, Jesús Vaquero
Tumours of the pineal region are rare in adulthood, accounting for approximately 1% of intracranial neoplasms in this age range. Because of their rarity, it has proven to be difficult to establish the optimal therapy. Furthermore, microsurgical total resection in this eloquent location is associated with not low rates of morbidity. We described two patients diagnosed of papillary tumours of the pineal region (PTPR) by stereotactic biopsy and referred for gamma knife radiosurgery after shunting for hydrocephalus...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29787878/gamma-knife-radiosurgery-of-the-superior-laryngeal-neuralgia-a-report-of-three-cases
#2
Peng Fu, Nan-Xiang Xiong, Ahmed Abdelmaksoud, Yi-Zhi Huang, Guo-Bin Song, Hong-Yang Zhao
BACKGROUND: Superior laryngeal neuralgia (SLN) is a relatively rare disorder that is characterized by neck pain. There are only a few reported cases and treatment options for SLN to date. OBJECTIVE: In this study, we reported 3 patients with SLN who were treated with gamma knife radiosurgery (GKRS) at the time of diagnosis. METHODS: For all 3 patients, GKRS was administered using a 4-mm collimator to deliver a single shot of 80 Gy of radiation (the 100% isodose line)...
May 19, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29786462/multi-institutional-study-of-the-variability-in-target-delineation-for-six-targets-commonly-treated-with-radiosurgery
#3
Helena Sandström, Hidefumi Jokura, Caroline Chung, Iuliana Toma-Dasu
BACKGROUND: Although accurate delineation of the target is a key factor of success in radiosurgery there are no consensus guidelines for target contouring. AIM: The aim of the present study was therefore to quantify the variability in target delineation and discuss the potential clinical implications, for six targets regarded as common in stereotactic radiosurgery. MATERIAL AND METHODS: Twelve Gamma Knife centers participated in the study by contouring the targets and organs at risks and performing the treatment plans...
May 22, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29775154/clinical-and-radiological-outcomes-of-proactive-gamma-knife-surgery-for-asymptomatic-meningiomas-compared-with-the-natural-course-without-intervention
#4
Kyung Hwan Kim, So Jeong Kang, Jung-Won Choi, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee
OBJECTIVE This study aimed to verify the effect of proactive Gamma Knife surgery (GKS) in the treatment of asymptomatic meningioma compared with the natural course without any therapeutic intervention. METHODS From January 2006 to May 2017, 354 patients newly diagnosed with asymptomatic meningioma were reviewed and categorized into GKS (n = 153) and observation (n = 201) groups. Clinical and radiological progression rates were examined, and changes in volume were analyzed. RESULTS Clinical progression (i.e...
May 18, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29769453/comparison-of-the-long-term-efficacy-and-safety-of-gamma-knife-radiosurgery-for-arteriovenous-malformations-in-pediatric-and-adult-patients
#5
Hirotaka Hasegawa, Shunya Hanakita, Masahiro Shin, Mariko Kawashima, Wataru Takahashi, Osamu Ishikawa, Satoshi Koizumi, Hirofumi Nakatomi, Nobuhito Saito
It is debated whether the efficacy and long-term safety of gamma knife radiosurgery (GKRS) for arteriovenous malformations (AVMs) differs between adult and pediatric patients. We aimed to clarify the long-term outcomes of GKRS in pediatric patients and how they compare to those in adult patients. We collected data for 736 consecutive patients with AVMs treated with GKRS between 1990 and 2014 and divided the patients into pediatric (age < 20 years, n = 144) and adult (age ≥ 20 years, n = 592) cohorts. The mean follow-up period in the pediatric cohort was 130 months...
May 17, 2018: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/29766927/microvascular-decompression-versus-stereotactic-radiosurgery-as-primary-treatment-modality-for-trigeminal-neuralgia-a-systematic-review-and-meta-analysis-of-prospective-comparative-trials
#6
REVIEW
Ravi Sharma, Manoj Phalak, Varidh Katiyar, Sachin Borkar, Shashank S Kale, Ashok K Mahapatra
Objective: The current opinion among neurosurgeons regarding the selection between microvascular decompression (MVD) and gamma knife radiosurgery for trigeminal neuralgia is not based on clear evidence. In this meta-analysis, we have attempted to synthesize the findings of the prospective trials comparing the efficacy and complications of the two procedures as primary treatment modality for medically refractory trigeminal neuralgia. Materials and Methods: The authors performed a systematic review of PubMed for manuscripts comparing the efficacy or complications of MVD and stereotactic radiosurgery for medically refractory trigeminal neuralgia...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29764622/absolute-cbv-for-the-differentiation-of-recurrence-and-radionecrosis-of-brain-metastases-after-gamma-knife-radiotherapy-a-comparison-with-relative-cbv
#7
B Wang, B Zhao, Y Zhang, M Ge, P Zhao, Na Sun, C Li, Q Pang, S Xu, Y Liu
AIM: To investigate the efficiency of absolute cerebral blood volume (CBV) in the differentiation of tumour recurrence (TR) and radionecrosis (RN) in brain metastases (BM) and to evaluate the performance of absolute CBV compared to relative CBV (rCBV). MATERIALS AND METHODS: Between March 2015 and June 2017, 46 patients with BM underwent quantitative dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI) because new enhancement had been demonstrated in irradiated lesions after gamma knife radiotherapy...
May 12, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29757421/stereotactic-radiosurgery-for-acromegaly-an-international-multicenter-retrospective-cohort-study
#8
Dale Ding, Gautam U Mehta, Mohana Rao Patibandla, Cheng-Chia Lee, Roman Liscak, Hideyuki Kano, Fu-Yuan Pai, Mikulas Kosak, Nathaniel D Sisterson, Roberto Martinez-Alvarez, Nuria Martinez-Moreno, David Mathieu, Inga S Grills, Kevin Blas, Kuei Lee, Christopher P Cifarelli, Gennadiy A Katsevman, John Y K Lee, Brendan McShane, Douglas Kondziolka, L Dade Lunsford, Mary Lee Vance, Jason P Sheehan
BACKGROUND: Stereotactic radiosurgery (SRS) is a treatment option for persistent or recurrent acromegaly secondary to a growth hormone secreting pituitary adenoma, but its efficacy is inadequately defined. OBJECTIVE: To assess, in a multicenter, retrospective cohort study, the outcomes of SRS for acromegaly and determine predictors. METHODS: We pooled and analyzed data from 10 participating institutions of the International Gamma Knife Research Foundation for patients with acromegaly who underwent SRS with endocrine follow-up of ≥6 mo...
May 10, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29754131/cavernous-sinus-meningioma-presenting-as-third-nerve-palsy-in-pregnancy
#9
Priya Nidamanuri, Dmitri Shastin, Ravindra Nannapaneni
A 33-year-old female patient presented with diplopia and left eye ptosis 26 weeks into her first pregnancy. No investigation was conducted at the time and her symptoms subsided 4 weeks post partum. This same phenomenon occurred during second pregnancy at 20 weeks of gestation, with patient becoming symptom-free again 6 weeks after giving birth. MRI revealed a lesion in the left cavernous sinus in keeping with a meningioma. Due to the surgically challenging location, the lesion was treated with gamma knife radiosurgery...
May 12, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29745754/modelling-the-influence-of-treatment-time-on-radiosurgery-single-treatment-biological-effectiveness-to-produce-protective-dose-modification-factors
#10
Bleddyn Jones, John W Hopewell
OBJECTIVE: To provide simpler models for adjusting total dose to compensate for significant variations in CNS radio-surgical treatment times, which vary and will influence treatment bio-effectiveness. At present, no allowance is made for time variations. A framework of simpler equations would allow radio-surgical outcomes to be analysed with respect to treatment time, and a system for dose adjustments between radio-isotope and linac-based techniques with different treatment durations...
May 10, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29743581/evolution-of-gamma-knife-capsulotomy-for-intractable-obsessive-compulsive-disorder
#11
REVIEW
Euripedes C Miguel, Antonio C Lopes, Nicole C R McLaughlin, Georg Norén, André F Gentil, Clement Hamani, Roseli G Shavitt, Marcelo C Batistuzzo, Edoardo F Q Vattimo, Miguel Canteras, Antonio De Salles, Alessandra Gorgulho, João Victor Salvajoli, Erich Talamoni Fonoff, Ian Paddick, Marcelo Q Hoexter, Christer Lindquist, Suzanne N Haber, Benjamin D Greenberg, Sameer A Sheth
For more than half a century, stereotactic neurosurgical procedures have been available to treat patients with severe, debilitating symptoms of obsessive-compulsive disorder (OCD) that have proven refractory to extensive, appropriate pharmacological, and psychological treatment. Although reliable predictors of outcome remain elusive, the establishment of narrower selection criteria for neurosurgical candidacy, together with a better understanding of the functional neuroanatomy implicated in OCD, has resulted in improved clinical efficacy for an array of ablative and non-ablative intervention techniques targeting the cingulum, internal capsule, and other limbic regions...
May 9, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29735881/-the-effect-of-pain-relieving-intervention-during-infiltration-among-gamma-knife-surgery-patients-for-stereotactic-frame-fixation
#12
Young Jun Jang, Hyeon Ok Kim
PURPOSE: This study aimed to compare the effects of three interventions on pain, blood pressure, and pulse rate during infiltration anesthesia in patients about to undergo gamma knife surgeries. METHODS: The three interventions employed in a university-affiliated Hospital in J City, South Korea were as follows: EMLA cream plus Vapocoolant spray (Vapocoolant, n=30), EMLA cream plus 10.0% Lidocaine spray (Lidocaine, n=30), and EMLA cream only (EMLA, n=30). The equivalent control-group pre test - post test study design was used...
April 2018: Journal of Korean Academy of Nursing
https://www.readbyqxmd.com/read/29724761/postcontrast-t1-mapping-for-differential-diagnosis-of-recurrence-and-radionecrosis-after-gamma-knife-radiosurgery-for-brain-metastasis
#13
B Wang, Y Zhang, B Zhao, P Zhao, M Ge, M Gao, F Ding, S Xu, Y Liu
BACKGROUND AND PURPOSE: The differential diagnosis of radionecrosis and tumor recurrence in brain metastases is challenging. We investigated the diagnostic efficiency of postcontrast T1 mapping in solving this problem. MATERIALS AND METHODS: Between March 2016 and June 2017, fifty-six patients with brain metastases who underwent contrast-enhanced cerebral T1 mapping were recruited for this prospective study. The findings revealed new enhancement after gamma knife radiosurgery...
May 3, 2018: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/29723733/positive-clinical-effects-of-gamma-knife-capsulotomy-in-a-patient-with-deep-brain-stimulation-refractory-tourette-syndrome-and-obsessive-compulsive-disorder
#14
Raphaëlle Richieri, Graham Blackman, Richard Musil, Giorgio Spatola, Andrea E Cavanna, Christophe Lançon, Jean Régis
We report the first case of a patient with severe, intractable Tourette Syndrome with comorbid Obsessive Compulsive disorder, who recovered from both disorders with gamma-knife (GK) stereotactic radiosurgery following deep brain stimulation (DBS). This case highlights the possible role of the internal capsule within the neural circuitries underlying both TS and OCD, and suggests that in cases of treatment-refractory TS and comorbid OCD, bilateral anterior capsulotomy using stereotactic radiosurgery may be a viable treatment option...
April 26, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29705231/efficacy-and-safety-of-microvascular-decompression-and-gamma-knife-surgery-treatments-for-patients-with-primary-trigeminal-neuralgia-a-prospective-study
#15
Yi Jun Zeng, Heng Zhang, Shui Yu, Wen Zhang, Xiao Chuan Sun
PURPOSE: To compare the efficacy and safety of microvascular decompression (MVD) and gamma knife surgery (GKS) treatments for trigeminal neuralgia. METHOD: Patients with primary trigeminal neuralgia were randomly divided into two groups to undergo either MVD or GKS. All patients were followed up for 2 years to evaluate the efficacy, recurrence rates, and complications of their treatment. RESULTS: Of the 441 enrolled patients, 220 were included in the MVD group and 221 were in the GKS group...
April 26, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29701557/stereotactic-radiosurgery-for-trigeminal-pain-secondary-to-recurrent-malignant-skull-base-tumors
#16
Jack Phan, Courtney Pollard, Paul D Brown, Nandita Guha-Thakurta, Adam S Garden, David I Rosenthal, Clifton D Fuller, Steven J Frank, G Brandon Gunn, William H Morrison, Jennifer C Ho, Jing Li, Amol J Ghia, James N Yang, Dershan Luo, He C Wang, Shirley Y Su, Shaan M Raza, Paul W Gidley, Ehab Y Hanna, Franco DeMonte
OBJECTIVE The objective of this study was to assess outcomes after Gamma Knife radiosurgery (GKRS) re-irradiation for palliation of patients with trigeminal pain secondary to recurrent malignant skull base tumors. METHODS From 2009 to 2016, 26 patients who had previously undergone radiation treatment to the head and neck received GKRS for palliation of trigeminal neuropathic pain secondary to recurrence of malignant skull base tumors. Twenty-two patients received single-fraction GKRS to a median dose of 17 Gy (range 15-20 Gy) prescribed to the 50% isodose line (range 43%-55%)...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29701555/stereotactic-radiosurgery-for-trigeminal-neuralgia-a-systematic-review
#17
Constantin Tuleasca, Jean Régis, Arjun Sahgal, Antonio De Salles, Motohiro Hayashi, Lijun Ma, Roberto Martínez-Álvarez, Ian Paddick, Samuel Ryu, Ben J Slotman, Marc Levivier
OBJECTIVES The aims of this systematic review are to provide an objective summary of the published literature specific to the treatment of classical trigeminal neuralgia with stereotactic radiosurgery (RS) and to develop consensus guideline recommendations for the use of RS, as endorsed by the International Society of Stereotactic Radiosurgery (ISRS). METHODS The authors performed a systematic review of the English-language literature from 1951 up to December 2015 using the Embase, PubMed, and MEDLINE databases...
April 27, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29698968/gamma-knife-stereotactic-radiosurgery-for-the-treatment-of-brain-metastases-from-primary-tumors-of-the-urinary-bladder
#18
James M Taylor, Emory R McTyre, Stephen B Tatter, Adrian W Laxton, Michael T Munley, Michael D Chan, Christina K Cramer
BACKGROUND/AIMS: Brain metastases from bladder cancer are rare and published outcomes data are sparse. To date, no institutions have reported a series of patients with brain metastases from bladder cancer treated with stereotactic radiosurgery (SRS). Our aim was to identify patients with brain metastases from bladder primaries treated with SRS with or without surgical resection and report the clinical outcomes. METHODS: Patients meeting eligibility criteria at our institution between 2000 and 2017 were included...
April 26, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29696532/quantitative-dynamic-susceptibility-contrast-perfusion-weighted-imaging-guided-customized-gamma-knife-re-irradiation-of-recurrent-high-grade-gliomas
#19
Bao Wang, Peng Zhao, Yi Zhang, Mingxu Ge, Chuanjin Lan, Chuanting Li, Qi Pang, Shangchen Xu, Yingchao Liu
INTRODUCTION: Treatment of recurrent high-grade gliomas (rHGG) has always been challenging. This study aimed to explore the treatment effect of quantitative dynamic susceptibility contrast perfusion-weighted imaging (DSC-PWI)-guided gamma knife radiosurgery (GKRS) on rHGG. METHODS: Between April 2014 and July 2016, 26 consecutive patients were treated by quantitative DSC-PWI-guided GKRS as salvage treatment for rHGG. The gross tumor volume (GTV) was defined as the high perfusion area on absolute cerebral blood volume maps, with a cutoff value of 22 ml/100 g...
April 26, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29696173/safety-and-efficacy-of-endovascular-therapy-and-gamma-knife-surgery-for-brain-arteriovenous-malformations-in-china-study-protocol-for-an-observational-clinical-trial
#20
Hengwei Jin, Xiaochuan Huo, Yuhua Jiang, Xiaolong Li, Youxiang Li
Introduction: Brain arteriovenous malformations (BAVMs) are associated with high morbidity and mortality. The treatment of BAVM remains controversial. Microinvasive treatment, including endovascular therapy and gamma knife surgery, has been the first choice in many conditions. However, the overall clinical outcome of microinvasive treatment remains unknown and a prospective trial is needed. Methods: This is a prospective, non-randomized, and multicenter observational registry clinical trial to evaluate the safety and efficacy of microinvasive treatment for BAVMs...
September 2017: Contemporary Clinical Trials Communications
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