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https://www.readbyqxmd.com/read/28338441/radiosurgery-in-the-management-of-brain-metastasis-a-retrospective-single-center-study-comparing-gamma-knife-and-linac-treatment
#1
Constantin Tuleasca, Laura Negretti, Mohamed Faouzi, Vera Magaddino, Thierry Gevaert, Erik von Elm, Marc Levivier
OBJECTIVE The authors present a retrospective analysis of a single-center experience with treatment of brain metastases using Gamma Knife (GK) and linear accelerator (LINAC)-based radiosurgery and compare the results. METHODS From July 2010 to July 2012, 63 patients with brain metastases were treated with radiosurgery. Among them, 28 (with 83 lesions) were treated with a GK unit and 35 (with 47 lesions) with a LINAC. The primary outcome was local progression-free survival (LPFS), evaluated on a per-lesion basis...
March 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28319282/stereotactic-radiosurgery-for-essential-tremor-retrospective-analysis-of-a-19-year-experience
#2
Ajay Niranjan, Sudesh S Raju, Ali Kooshkabadi, Edward Monaco, John C Flickinger, L Dade Lunsford
BACKGROUND: Essential Tremor (ET) is a common movement disorder that can be disabling. Initial treatment is in the form of medical therapies. Patients with medically refractory ET seek surgical intervention which include radiofrequency thalamotomy, deep brain stimulation, and radiosurgical thalamotomy. Radiosurgical thalamotomy is a minimally invasive surgical option which is especially valuable for elderly and high surgical risk patients. OBJECTIVE: The purpose of this study was to retrospectively analyze the outcomes of stereotactic radiosurgery for patients suffering from medically refractory essential tremor...
March 20, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28298033/diffusion-tractography-imaging-guided-frameless-linear-accelerator-stereotactic-radiosurgical-thalamotomy-for-tremor-case-report
#3
Won Kim, Justin Sharim, Stephen Tenn, Tania Kaprealian, Yvette Bordelon, Nzhde Agazaryan, Nader Pouratian
Essential tremor and Parkinson's disease-associated tremor are extremely prevalent within the field of movement disorders. The ventral intermediate (VIM) nucleus of the thalamus has been commonly used as both a neuromodulatory and neuroablative target for the treatment of these forms of tremor. With both deep brain stimulation and Gamma Knife radiosurgery, there is an abundance of literature regarding the surgical planning, targeting, and outcomes of these methodologies. To date, there have been no reports of frameless, linear accelerator (LINAC)-based thalomotomies for tremor...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28298028/intracranial-intraaxial-cerebral-tufted-angioma-case-report
#4
Randy S D'Amico, George Zanazzi, Gunnar Hargus, Timothy Dyster, Shirley Chan, Angela Lignelli-Dipple, Tony J C Wang, Phyllis L Faust, Guy M McKhann
Tufted angioma (TA) is a rare, slow-growing, vascular lesion that commonly presents as a solitary macule, papule, or nodule arising in the soft tissues of the torso, extremities, and head and neck in children and young adults. Adult-onset cases have been infrequently reported. While typically benign, TAs may be locally aggressive. Complete physical examination and hematological workup are recommended in patients with TA to exclude the presence of Kasabach-Merritt phenomenon (KMP). The authors describe the case of a 69-year-old man with a contrast-enhancing frontal lobe lesion, with surrounding vasogenic edema, which was treated by gross-total resection...
February 24, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297343/evaluation-of-the-stability-of-the-stereotactic-leksell-frame-g-in-gamma-knife-radiosurgery
#5
Alvaro Rojas-Villabona, Katherine Miszkiel, Neil Kitchen, Rolf Jäger, Ian Paddick
The purpose of this study was to evaluate the stability of the Leksell Frame G in Gamma Knife radiosurgery (GKR). Forty patients undergoing GKR underwent pretreatment stereotactic MRI for GKR planning and stereotactic CT immediately after GKR. The stereotactic coordinates of four anatomical landmarks (cochlear apertures and the summits of the anterior post of the superior semicircular canals, bilaterally) were measured by two evaluators on two separate occasions in the pretreatment MRI and post-treatment CT scans and the absolute distance between the observations is reported...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297297/investigation-of-dosimetric-differences-between-the-tmr-10-and-convolution-algorithm-for-gamma-knife-stereotactic-radiosurgery
#6
Alvaro Rojas-Villabona, Neil Kitchen, Ian Paddick
Since its inception, doses applied using Gamma Knife Radiosurgery (GKR) have been calculated using a simple TMR algorithm, which assumes the patient's head is of even density, the same as water. This results in a significant approximation of the dose delivered by the Gamma Knife. We investigated how GKR dose calculations varied when using a new convolution algorithm clinically available for GKR planning that takes into account density variations in the head compared with the established calculation algorithm...
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296312/two-year-experience-with-the-commercial-gamma-knife-check-software
#7
Andy Yuanguang Xu, Jagdish Bhatnagar, Greg Bednarz, Josef Novotny, John Flickinger, L Dade Lunsford, M Saiful Huq
The Gamma Knife Check software is an FDA approved second check system for dose calculations in Gamma Knife radiosurgery. The purpose of this study was to evaluate the accuracy and the stability of the commercial software package as a tool for independent dose verification. The Gamma Knife Check software version 8.4 was commissioned for a Leksell Gamma Knife Perfexion and a 4C unit at the University of Pittsburgh Medical Center in May 2012. Independent dose verifications were performed using this software for 319 radiosurgery cases on the Perfexion and 283 radiosurgery cases on the 4C units...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296303/development-of-a-monte-carlo-model-for-treatment-planning-dose-verification-of-the-leksell-gamma-knife-perfexion-radiosurgery-system
#8
Jiankui Yuan, Simon S Lo, Yiran Zheng, Jason W Sohn, Andrew E Sloan, Rodney Ellis, Mitchell Machtay, Barry Wessels
Detailed Monte Carlo (MC) modeling of the Leksell Gamma Knife (GK) Perfexion (PFX) collimator system is the only accurate ab initio approach appearing in the literature. As a different approach, in this work, we present a MC model based on film measurement. By adjusting the model parameters and fine-tuning the derived fluence map for each individual source to match the manufacturer's ring output factors, we created a reasonable virtual source model for MC simulations to verify treatment planning dose for the GK PFX radiosurgery system...
July 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28272674/the-role-of-egfr-hepatocyte-growth-factor-receptor-c-met-c-erbb2-her2-neu-and-clinicopathological-parameters-in-the-pathogenesis-and-prognosis-of-chordoma
#9
Zeynep Tosuner, Süheyla Uyar Bozkurt, Türker Kiliç, Baran Yilmaz
OBJECTIVE: Chordoma is a rare malignant bone tumor with a poor outcome. Although radiotherapy and gamma knife surgery have been used for treatment, providing a cure for the tumor is not easy, because of the frequent recurrences. Molecular targeted therapy against tyrosine kinases has been effective in the treatment of malignancies such as breast and lung cancers and brain tumors. We aimed to analyse the histopathological features of chordomas and the immunoexpression profiles of the three receptor tyrosine kinases of EGFR, c-Met and c-Erb-B2 in chordomas...
February 4, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28258282/evaluation-of-auditory-pathways-using-dti-in-patients-treated-with-gamma-knife-radiosurgery-for-acoustic-neuroma-a%C3%A2-preliminary-report
#10
Serpil Kurtcan, Mustafa Aziz Hatiboglu, Alpay Alkan, Huseyin Toprak, Mehmet Hakan Seyithanoglu, Ayse Aralasmak, Bahar Atasoy, Omer Uysal
PURPOSE: We aimed to evaluate the change in bilateral auditory pathways using diffusion tensor imaging (DTI) after gamma knife radiosurgery (GKR) and to determine the relationship between the radiosurgical treatment variables and DTI findings. METHODS: In this study 13 patients with unilateral acoustic neuroma and 11 controls underwent routine magnetic resonance imaging (MRI) and DTI. The apparent diffusion coefficient (ADC) and fractional anisotropy (FA) were measured from the bilateral auditory pathways in all individuals before and after GKR...
March 3, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28247112/pediatric-infratentorial-meningiomas-a-series-of-19-cases-and-review-of-the-literature
#11
Hai Liu, Wei Luo, Jiaxin Li, Jun Yang, Yulun Xu
PURPOSE: Pediatric infratentorial meningiomas are extremely rare. In this article, we present a series of 19 cases operated at our institution in the last 8 years. METHODS: During the 8-year period from January 2008 to December 2015, we encountered 21 cases suffered from infratentorial meningiomas. Two patients were excluded. The clinical profiles, radiological features, surgical procedures, intraoperative findings, and outcomes were extracted from the patient records and neuroimaging data...
February 28, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28228892/metastatic-extrapleural-malignant-solitary-fibrous-tumor-presenting-with-hypoglycemia-doege-potter-syndrome
#12
Andrew J Degnan, Kenneth K W Lee, Marta I Minervini, Amir A Borhani
We report a rare case of metastatic malignant solitary fibrous tumor (SFT) that presented with hypoglycemia because of insulin growth factor-2 production. Initial workup included computed tomography imaging that revealed a large, partially necrotic liver mass, a hypervascular pancreatic head lesion, and 2 renal lesions. Following hepatic resection, pancreatic head resection and nephrectomy, all these lesions demonstrated pathological findings that were consistent with SFT. The patient also had a history of an intracranial mass that had been previously resected and treated with gamma knife therapy at an outside institution, which was found to also be SFT...
March 2017: Radiology case reports
https://www.readbyqxmd.com/read/28220368/embolization-of-ruptured-arteriovenous-malformations-in-the-cerebellopontine-angle-cistern
#13
Hidenori Endo, Shin-Ichiro Osawa, Yasushi Matsumoto, Toshiki Endo, Kenichi Sato, Kuniyasu Niizuma, Miki Fujimura, Teiji Tominaga
Among brainstem arteriovenous malformations (AVMs), there exist small AVMs predominantly located in the cerebellopontine angle cistern (CPAC) with minimal extension into the pial surface of the brainstem. However, previous studies of CPAC AVMs did not particularly discuss the role of embolization in the treatment of these lesions. This study was conducted to clarify the effectiveness and validity of embolization in the treatment of CPAC AVMs. We retrospectively reviewed five patients with CPAC AVMs who underwent endovascular treatment...
February 20, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28217873/radiosurgery-for-arteriovenous-malformations-and-the-impact-on-headaches
#14
Greg Bowden, Jonathon Cavaleri, Hideyuki Kano, Edward Monaco, Ajay Niranjan, John Flickinger, L Dade Lunsford
BACKGROUND: Arteriovenous malformations (AVMs) can underlie many diverse neurological signs and symptoms. Headaches are a common presentation that can have a significant impact on quality of life. OBJECTIVE: The authors investigated Gamma Knife(®) stereotactic radiosurgery (SRS) outcomes in patients with AVMs and associated headaches. METHODS: This retrospective study analyzed 102 patients with AVMs who underwent SRS between 1995 and 2013...
February 20, 2017: Headache
https://www.readbyqxmd.com/read/28216397/gamma-knife-radiosurgery-for-low-grade-gliomas-clinical-results-at-long-term-follow-up-on-tumor-control-and-patients-quality-of-life
#15
Filippo Gagliardi, Michele Bailo, Alfio Spina, Carmine A Donofrio, Nicola Boari, Alberto Franzin, Arianna Fava, Antonella Del Vecchio, Angelo Bolognesi, Pietro Mortini
OBJECT: Surgery represents first-line therapy for low-grade gliomas (LGGs), in some cases followed by radiotherapy (RT) and chemotherapy. Gamma Knife radiosurgery (GKRS) has gained more relevance in the management of these tumors. The aim of the study was to assess the efficacy and safety of GKRS for the treatment of LGGs. METHODS: Forty-two treatments, performed between 2001 and 2014 on 39 patients harboring LGGs, were included. Forty-eight percent of patients underwent previous surgery, while 20...
February 16, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28191290/loss-of-efficacy-of-pasireotide-after-its-re-administration-is-there-a-reason-why
#16
Stylianos Mandanas, Lemonia Mathiopoulou, Maria Boudina, Alexandra Chrisoulidou, Kalliopi Pazaitou-Panayiotou
Pasireotide is a recently approved medical treatment for persistent or recurrent Cushing's disease (CD). However, an escape from the initial successful response has not yet been described. A 42-year-old female presented with several symptoms indicative of hypercortisolism. Biochemical evaluation and imaging were consistent with CD due to a pituitary adenoma. Surgical excision of the adenoma was unsuccessful and gamma-knife radiosurgery was followed. Our patient remained hypercortisolemic thus treatment with pasireotide (900 mg subcutaneously twice daily) was decided...
November 17, 2016: Rare Tumors
https://www.readbyqxmd.com/read/28186452/magnetic-resonance-imaging-characteristics-and-the-prediction-of-outcome-of-vestibular-schwannomas-following-gamma-knife-radiosurgery
#17
Chih-Chun Wu, Wan-Yuo Guo, Wen-Yuh Chung, Hisu-Mei Wu, Chung-Jung Lin, Cheng-Chia Lee, Kang-Du Liu, Huai-Che Yang
OBJECTIVE Gamma Knife surgery (GKS) is a promising treatment modality for patients with vestibular schwannomas (VSs), but a small percentage of patients have persistent postradiosurgical tumor growth. The aim of this study was to determine the clinical and quantitative MRI features of VS as predictors of long-term tumor control after GKS. METHODS The authors performed a retrospective study of all patients with VS treated with GKS using the Leksell Gamma Knife Unit between 2005 and 2013 at their institution...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28186449/efficacy-and-outcomes-of-facial-nerve-sparing-treatment-approach-to-cerebellopontine-angle-meningiomas
#18
Randy S D'Amico, Matei A Banu, Petros Petridis, Alexandra S Bercow, Hani Malone, Moshe Praver, Tony J C Wang, Steven R Isaacson, Michael B Sisti
OBJECTIVE Advanced microsurgical techniques contribute to reduced morbidity and improved surgical management of meningiomas arising within the cerebellopontine angle (CPA). However, the goal of surgery has evolved to preserve the quality of the patient's life, even if it means leaving residual tumor. Concurrently, Gamma Knife radiosurgery (GKRS) has become an acceptable and effective treatment modality for newly diagnosed, recurrent, or progressive meningiomas of the CPA. The authors review their institutional experience with CPA meningiomas treated with GKRS, surgery, or a combination of surgery and GKRS...
February 10, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28185974/direct-comparison-of-gamma-knife-radiosurgery-and-microsurgery-for-small-size-meningiomas
#19
Shyamal C Bir, Devi Prasad Patra, Tanmoy Kumar Maiti, Papireddy Bollam, Alireza Minagar, Anil Nanda
INTRODUCTION: A patient with a small (<3cm) intracranial meningioma can be either observed or treated. Treatment can be either radiosurgery or microsurgery if and when progression of the tumor occurs. We have compared the local tumor growth control and recurrence-free survival (RFS) of microsurgical resection and radiosurgery in small intracranial meningiomas, and we have identified the predictors of unfavorable outcome. MATERIALS AND METHODS: Retrospective review (2005-2016) of 90 consecutive patients with intracranial meningiomas who underwent either microsurgery (n=31) or gamma knife radiosurgery (GKRS, n=59) was done...
February 6, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28183144/rapid-deterioration-of-latent-hbv-hepatitis-during-cushing-disease-and-posttraumatic-stress-disorder-after-earthquake
#20
Ryosuke Tashiro, Yoshikazu Ogawa, Teiji Tominaga
Reactivation of the hepatitis B virus (HBV) is a risk in the 350 million HBV carriers worldwide. HBV reactivation may cause hepatocellular carcinoma, cirrhosis, and fulminant hepatitis, and HBV reactivation accompanied with malignant tumor and/or chemotherapy is a critical problem for patients with chronic HBV infection. Multiple risk factors causing an immunosuppressive state can also induce HBV reactivation.We present a case of HBV reactivation during an immunosuppressive state caused by Cushing disease and physical and psychological stress after a disaster...
February 9, 2017: Journal of Neurological Surgery. Part A, Central European Neurosurgery
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