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https://www.readbyqxmd.com/read/28623753/precuneal-epilepsy-clinical-features-and-surgical-outcome
#1
Adil Harroud, Olivier Boucher, Thi Phuoc Yen Tran, Louis Harris, Jeffery Hall, François Dubeau, Ismail Mohamed, Alain Bouthillier, Dang Khoa Nguyen
OBJECTIVE: The precuneus is a complex and highly connected structure located in the medial portion of the superior parietal lobule. The clinical presentation of precuneal epilepsy is poorly characterized, mostly because these patients have seldom been distinguished from those with other types of parietal lobe epilepsy. The present study aims to improve the understanding of precuneal epilepsy by detailing its clinical features and surgical outcomes. METHODS: Six previously unreported cases of drug-resistant precuneal epilepsy investigated between 2002 and 2014 were retrospectively studied...
June 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28621628/gamma-knife-surgery-for-clival-epidural-osseous-dural-arteriovenous-fistulas
#2
Cheng-Chia Lee, Ching-Jen Chen, Shao-Ching Chen, Huai-Che Yang, Chung Jung Lin, Chih-Chun Wu, Wen-Yuh Chung, Wan-Yuo Guo, David Hung-Chi Pan, Cheng-Ying Shiau, Hsiu-Mei Wu
OBJECTIVE Clival epidural-osseous dural arteriovenous fistula (DAVF) is often associated with a large nidus, multiple arterial feeders, and complex venous drainage. In this study the authors report the outcomes of clival epidural-osseous DAVFs treated using Gamma Knife surgery (GKS). METHODS Thirteen patients with 13 clival epidural-osseous DAVFs were treated with GKS at the authors' institution between 1993 and 2015. Patient age at the time of GKS ranged from 38 to 76 years (median 55 years). Eight DAVFs were classified as Cognard Type I, 4 as Type IIa, and 1 as Type IIa+b...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28621622/glossopharyngeal-neuralgia-treated-by-gamma-knife-radiosurgery-safety-and-efficacy-through-long-term-follow-up
#3
Benjamin Pommier, Gustavo Touzet, Christian Lucas, Maximilien Vermandel, Serge Blond, Nicolas Reyns
OBJECTIVE Glossopharyngeal neuralgia (GPN) is a rare and disabling condition. Just as for trigeminal neuralgia, Gamma Knife radiosurgery (GKRS) is increasingly proposed as a therapeutic option for GPN. The purpose of this study was to assess long-term safety and efficacy of GKRS for this indication. METHODS From 2007 to 2015, 9 patients (4 male and 5 female) underwent a total of 10 GKRS procedures. All of the patients presented with GPN that was refractory to all medical treatment, and all had a long history of pain...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28619837/differentiation-between-treatment-induced-necrosis-and-recurrent-tumors-in-patients-with-metastatic-brain-tumors-comparison-among-11-c-methionine-pet-fdg-pet-mr-permeability-imaging-and-mri-adc-preliminary-results
#4
N Tomura, M Kokubun, T Saginoya, Y Mizuno, Y Kikuchi
BACKGROUND AND PURPOSE: In patients with metastatic brain tumors after gamma knife radiosurgery, the superiority of PET using (11)C-methionine for differentiating radiation necrosis and recurrent tumors has been accepted. To evaluate the feasibility of MR permea- bility imaging, it was compared with PET using (11)C-methionine, FDG-PET, and DWI for differentiating radiation necrosis from recurrent tumors. MATERIALS AND METHODS: The study analyzed 18 lesions from 15 patients with metastatic brain tumors who underwent gamma knife radiosurgery...
June 15, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28614989/a-challenging-entity-of-endovascular-embolization-with-onyx-for-brainstem-arteriovenous-malformation-experience-from-13-cases
#5
Hengwei Jin, Zhan Liu, Qing Chang, Chang Chen, Huijian Ge, Xianli Lv, Youxiang Li
Objective Brainstem arteriovenous malformations (AVMs) are rare lesions with a high risk of intracranial hemorrhage and are challenging to treat. We present our experience of endovascular embolization with Onyx in these aggressive lesions. Materials and methods Between 2007 and 2016, 13 patients with brainstem AVMs were embolized with Onyx at our center. Twelve patients presented with intracranial hemorrhage and one with headache. Retrospective examinations of patient demographics, clinical presentation, angiographic features, treatment modalities, postoperative complications and outcomes were carried out...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28607829/adaptive-hypofractionated-gamma-knife-radiosurgery-in-the-acute-management-of-large-thymic-carcinoma-brain-metastases
#6
Georges Sinclair, Heather Martin, Michael Fagerlund, Amir Samadi, Hamza Benmakhlouf, Ernest Doodo
BACKGROUND: Brain metastases often lead to serious neurological impairment and life threatening states. Their acute management remains complex, particularly in the case of rare malignancies with aggressive evolution. In large single lesions, open surgery followed by radiation to the surgical cavity is widely regarded as the best approach; yet in many cases, microsurgery is not feasible due to the lesion's critical location and/or the number of brain metastases present. We report the effects of adaptive hypofractionated gamma knife radiosurgery in the acute management of critically located thymic carcinoma metastases...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28599073/a-monte-carlo-model-and-its-commissioning-for-the-leksell-gamma-knife-perfexion-radiosurgery-system
#7
Jiankui Yuan, Mitchell Machtay
PURPOSE: To develop and commission a Monte Carlo (MC) simulation model for the Leksell Gamma Knife (LGK) Perfexion (PFX) radiosurgery system. METHOD: We previously established a source model for MC simulations of the LGK PFX for the purpose of the treatment planning system (TPS) dose verification and plan evaluation. To make practical and effective use of the model in clinic, several issues need to be addressed. First, thorough commissioning procedures are needed to ensure the validity of the model parameters, such as the source-to-focus (STF) distance, the source solid angle...
June 9, 2017: Medical Physics
https://www.readbyqxmd.com/read/28593112/comparative-neurologic-outcomes-of-salvage-and-definitive-gamma-knife-radiosurgery-for-glomus-jugulare-a-20-year-experience
#8
Daniel V Wakefield, Garrett T Venable, Noam A VanderWalde, L Madison Michael, Jeffery M Sorenson, Jon H Robertson, David Cunninghan, Matthew T Ballo
Objective  This case series investigates management of glomus jugulare (GJ) tumors utilizing definitive and salvage Gamma Knife stereotactic radiosurgery (GKSRS). Methods  A retrospective chart review was performed to collect data. Statistical analysis included patient, tumor, and treatment information. Results  From 1996 to 2013, 17 patients with GJ received GKSRS. Median age was 64 years (range, 27-76). GKSRS was delivered for definitive treatment in eight (47%) and salvage in nine (53%) patients. Median tumor volume was 9...
June 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/28591484/safety-and-efficacy-of-gamma-knife-radiosurgery-in-hypothalamic-hamartomas-with-severe-epilepsies-a-prospective-trial-in-48-patients-and-review-of-the-literature
#9
Jean Régis, Medhi Lagmari, Romain Carron, Motohiro Hayashi, Aileen McGonigal, Géraldine Daquin, Nathalie Villeneuve, Virginie Laguitton, Fabrice Bartolomei, Patrick Chauvel
Epilepsies associated with hypothalamic hamartomas (HHs) are frequently drug resistant with severe psychiatric and cognitive comorbidities. We performed a prospective trial to evaluate the safety and efficacy of Gamma Knife radiosurgery (GKS). Between October 1999 and October 2007, a total of 57 patients were investigated, included and treated by GKS in Timone University Hospital. Preoperative workup and 3-year postoperative evaluation consisted of seizure diary, neuropsychological, psychiatric, endocrinologic, visual field, and visual acuity examinations...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28591475/gamma-knife-radiosurgery-for-hypothalamic-hamartoma-preserves-endocrine-functions
#10
Frederic Castinetti, Thierry Brue, Isabelle Morange, Romain Carron, Jean Régis
Gamma Knife radiosurgery (GK) is an effective treatment for hypothalamic hamartoma. No precise data are available on the risk of endocrine side effects of this treatment. In this study, 34 patients with hypothalamic hamartoma (HH) were followed prospectively at the Department of Endocrinology, La Timone Hospital, Marseille, France, for a mean follow-up of >2 years (mean ± standard deviation [SD] 3.6 ± 2 years). Initial pre- and post-GK radiosurgery evaluations were performed, including weight, body mass index (BMI), and a complete endocrinological workup...
June 2017: Epilepsia
https://www.readbyqxmd.com/read/28589468/optimal-treatment-of-jugular-foramen-schwannomas-long-term-outcome-of-a-multidisciplinary-approach-for-a-series-of-29-cases-in-a-single-institute
#11
Sung Mo Ryu, Jung-Il Lee, Kwan Park, Jung Won Choi, Doo-Sik Kong, Do-Hyun Nam, Han-Shin Jeong, Yang-Sun Cho, Ho Jun Seol
BACKGROUND: The goal of treatment for jugular foramen schwannomas (JFSs) is to achieve complete tumor removal with cranial nerve preservation. However, achieving this goal remains a challenge despite the advances in microsurgical techniques. The aim of this study was to determine optimal treatment strategies for JFSs based on a review of a series of 29 surgical cases in our institute. MATERIALS AND METHODS: Between 1997 and 2013, 29 patients with JFSs underwent surgical treatment by multidisciplinary otoneurosurgical approaches...
June 6, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28588789/curative-effect-of-stereotactic-body-radiotherapy-for-unresectable-massive-primary-liver-cancer
#12
Ya-Zheng Dang, Xin Li, Shi-Gao Huang, Wan-Ling Lu, Guodong Wang, Dongxian Zhang, Qian-Yun Wang
The aim of this study was to evaluate the curative effect of gamma knife stereotactic body radiotherapy (SBRT) for unresectable massive primary liver cancer. A total of 69 patients with unresectable massive (>10 cm) primary liver cancer who were treated by SBRT at the Department of Radiation Oncology of the 323 Hospital of People's Liberation Army (Xi'an, China) between October, 2006 and October, 2010, were analyzed. According to the Union for International Cancer Control TNM staging guidelines, the patients were graded as stage T1 (n=8), T2 (n=12), T3 (n=21) and T4 (n=28)...
June 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28574311/erratum-gamma-knife-radiosurgery-for-recurrent-or-residual-seizures-after-anterior-temporal-lobectomy-in-mesial-temporal-lobe-epilepsy-patients-with-hippocampal-sclerosis-long-term-follow-up-results-of-more-than-4-years
#13
https://www.readbyqxmd.com/read/28560050/gamma-knife-radiosurgery-for-the-treatment-of-uveal-melanoma-and-uveal-metastases
#14
Margaret M Reynolds, Andrea L Arnett, Ian F Parney, Ravi Kumar, Nadia N Laack, Patrick R Maloney, Timothy F Kozelsky, Yolanda I Garces, Robert L Foote, Jose S Pulido
BACKGROUND: This study retrospectively analyzed outcomes for patients undergoing gamma knife radiosurgery (GKR) for uveal melanoma (UM) and intraocular metastases. METHODS: Patients who underwent GKR for UM or intraocular metastases between 1/1/1990 and 6/1/2015 at Mayo Clinic, Rochester, MN, USA, were retrospectively analyzed. RESULTS: Eleven patients (11 eyes) had UM while seven patients (7 eyes) had intraocular metastases. Patients with UM were followed for a median of 19...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28553615/a-single-institution-analysis-of-126-patients-treated-with-stereotactic-radiosurgery-for-brain-metastases
#15
Kevin B Harris, Melanie R Corbett, Henry Mascarenhas, Kenneth Stuart Lee, Hyder Arastu, Clinton Leinweber, Andrew W Ju
BACKGROUND: The objective of this study was to report our institutional experience with Gamma Knife(®) Radiosurgery (GKRS) in the treatment of patients with brain metastases. METHODS: Retrospectively collected demographic and clinical data on 126 patients with intracranial metastases were reviewed. The patients in our study underwent GKRS at Vidant Medical Center between 2009 and 2014. Kaplan-Meier curves were used to compare survival based on clinical characteristics for univariate analysis, and a Cox proportional hazards model was used for multivariate analysis...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28537768/hypopituitarism-after-gamma-knife-radiosurgery-for-pituitary-adenoma
#16
Karin Zibar Tomšić, Tina Dušek, Ivana Kraljević, Zdravko Heinrich, Mirsala Solak, Ana Vučinović, David Ozretić, Sergej Mihailović Marasanov, Hrvoje Hršak, Darko Kaštelan
PURPOSE: The aim of the study was to investigate the incidence of and risk factors for hypopituitarism after gamma knife radiosurgery (GKRS) for pituitary adenoma. MATERIALS AND METHODS: We conducted a retrospective analysis of the pituitary function of 90 patients who underwent GKRS for pituitary adenoma at the University Hospital Centre Zagreb between 2003 and 2014. Twenty seven of them met the inclusion criteria and the others were excluded from the study due to pituitary insufficiency which was present before GKRS...
May 24, 2017: Endocrine Research
https://www.readbyqxmd.com/read/28536992/mgmt-promoter-methylation-status-as-a-prognostic-factor-for-the-outcome-of-gamma-knife-radiosurgery-for-recurrent-glioblastoma
#17
Byung Sup Kim, Doo-Sik Kong, Ho Jun Seol, Do-Hyun Nam, Jung-Il Lee
We conducted this study to determine whether the methylation status of the O(6)-methylguanine-DNA methyltransferase (MGMT) promoter was a prognostic marker for positive outcomes of gamma knife radiosurgery (GKS) for recurrent glioblastoma (GBM). We retrospectively examined 61 patients, who underwent GKS for local recurrent GBM between 2004 and 2015; in all patients, the methylation status of the MGMT promoter was identified via methylation-specific quantitative real-time polymerase chain reaction. All patients underwent surgical resection and were diagnosed histopathologically with GBM...
May 23, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28536967/optimization-of-diagnostic-performance-for-differentiation-of-recurrence-from-radiation-necrosis-in-patients-with-metastatic-brain-tumors-using-tumor-volume-corrected-11-c-methionine-uptake
#18
Tae-Young Jung, In-Young Kim, Sa-Hoe Lim, Ki Seong Park, Dong-Yeon Kim, Shin Jung, Kyung-Sub Moon, Woo-Youl Jang, Sae-Ryung Kang, Sang-Geon Cho, Jung-Joon Min, Hee-Seung Bom, Seong Young Kwon
BACKGROUND: Tumor to normal tissue ratio (T/N ratio) on (11)C-methionine ((11)C-MET) positron emission tomography/computed tomography (PET/CT) is affected by variable factors. We investigated whether T/N ratio cutoff values corrected according to metabolic tumor volume (MTV) could improve the diagnostic performance of (11)C-MET PET/CT for diagnosis of recurrence in patients with metastatic brain tumor. Forty-eight patients with metastatic brain tumors underwent (11)C-MET PET/CT for differential diagnosis between recurrence and radiation necrosis after gamma knife radiosurgery (GKR)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28536486/emerging-indications-for-fractionated-gamma-knife-radiosurgery
#19
Emory McTyre, Corbin A Helis, Michael Farris, Lisa Wilkins, Darrell Sloan, William H Hinson, J Daniel Bourland, William A Dezarn, Michael T Munley, Kounosuke Watabe, Fei Xing, Adrian W Laxton, Stephen B Tatter, Michael D Chan
BACKGROUND: Gamma Knife radiosurgery (GKRS) allows for the treatment of intracranial tumors with a high degree of dose conformality and precision. There are, however, certain situations wherein the dose conformality of GKRS is desired, but single session treatment is contraindicated. In these situations, a traditional pin-based GKRS head frame cannot be used, as it precludes fractionated treatment. OBJECTIVE: To report our experience in treating patients with fractionated GKRS using a relocatable, noninvasive immobilization system...
February 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28532912/gamma-knife-radiosurgery-for-idiopathic-trigeminal-neuralgia-does-the-status-of-offending-vessels-influence-on-pain-control-or-side-effects
#20
Hyun Ho Jung, Chang Kyu Park, Na Young Jung, Minsoo Kim, Won Seok Chang, Jin Woo Chang
OBJECTIVE: To determine pain control and side effects after gamma knife radiosurgery (GKRS) for classical idiopathic trigeminal neuralgia (TN) with or without neurovascular compression (NVC). METHODS: This study included 47 patients with type 1 idiopathic TN and Barrow Neurological Institute (BNI) pain class IV or V that were treated with GKRS, with maximal dose of 85 Gy targeting root entry zone, as a first-treatment modality between January 2005 and March 2015...
May 19, 2017: World Neurosurgery
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