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https://www.readbyqxmd.com/read/29351691/out-of-field-doses-in-children-treated-for-large-arteriovenous-malformations-using-hypofractionated-gamma-knife-radiosurgery-and-intensity-modulated-radiation-therapy
#1
Marijke De Saint-Hubert, Marija Majer, Hrvoje Hršak, Zdravko Heinrich, Željka Kneževic, Saveta Miljanic, Paulina Porwol, Liliana Stolarczyk, Filip Vanhavere, Roger M Harrison
The purpose of this study was to measure out-of-field organ doses in two anthropomorphic child phantoms for the treatment of large brain arteriovenous malformations (AVMs) using hypofractionated gamma knife (GK) radiosurgery and to compare these with an alternative treatment using intensity-modulated radiation therapy (IMRT). Target volume was identical in size and shape in all cases. Radiophotoluminescent (RPL), thermoluminescent (TL) and optically stimulated luminescent (OSL) dosimeters were used for out-of-field dosimetry during GK treatment and a good agreement within 1-2% between results was shown...
January 17, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29342035/systematic-review-of-hearing-preservation-after-radiotherapy-for-vestibular-schwannoma
#2
Adam R Coughlin, Tyler J Willman, Samuel P Gubbels
OBJECTIVE: To determine the long-term hearing preservation rate for spontaneous vestibular schwannoma treated by primary radiotherapy. DATA SOURCES: The MEDLINE/PubMed, Web of Science, Cochrane Reviews, and EMBASE databases were searched using a comprehensive Boolean keyword search developed in conjunction with a scientific librarian. English language papers published from 2000 to 2016 were evaluated. STUDY SELECTION: Inclusion criteria: full articles, pretreatment and posttreatment audiograms or audiogram based scoring system, vestibular schwannoma only tumor type, reported time to follow-up, published after 1999, use of either Gamma Knife or linear accelerator radiotherapy...
January 16, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29338969/current-and-future-challenges-of-radiation-oncology-in-iran-a-report-from-the-iranian-society-of-clinical-oncology
#3
A Ameri, M Barzegartahamtan, M Ghavamnasiri, R Mohammadpour, H Dehghan, A Sebzari, K Novin, M Aloosh
AIMS: Growth of the cancer incidence rate in Iran has been very high in recent years. Therefore, the Iranian health care system should be prepared for the treatment of a huge number of patients in the foreseeable future. One of the most important treatment options for cancer is radiation. However, there is no comprehensive information on infrastructure for radiation oncology in this country. MATERIALS AND METHODS: In 2015, a questionnaire was designed by the Iranian Society of Clinical Oncology (ISCO) and all radiation oncology centres in the country were visited to determine four important components of radiation oncology services, including facilities, equipment, personnel and patients...
January 12, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29332080/radiosurgical-pallidotomy-for-parkinson-s-disease
#4
Leslie D Cahan, Ronald F Young, Francisco Li
Deep brain stimulation (DBS) has been widely accepted as a tool for treating many symptoms of Parkinson's disease (PD); pallidotomy has been nearly abandoned. Concerns about both the safety and efficacy of pallidotomy are based on small series, isolated case reports, and techniques that would now be considered obsolete. The senior author recently reviewed long-term follow-up of a series of patients who had gamma knife pallidotomy (GKP) for advanced PD. GKP leads to durable, clinically significant benefit. Bilateral GKP adds incremental improvement...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29332078/magnetic-resonance-guided-high-intensity-focused-ultrasound-for-treating-movement-disorders
#5
Young Goo Kim, Eun Jung Kweon, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
Transcranial magnetic resonance-guided focused ultrasound (MRgFUS) surgery has recently gained favor as a novel, noninvasive alternative to conventional neurosurgery. In contrast to traditional ablative interventions, transcranial MRgFUS surgery is entirely imaging-guided and uses continuous temperature measurements at the target and surrounding tissue taken in real-time. Unlike Gamma Knife radiosurgery, MRgFUS surgery can make a lesion immediately and does not use ionizing radiation. Moreover, since no metallic device is implanted, MR imaging-based diagnosis is not restricted throughout life...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29328001/gamma-knife-radiosurgery-of-saccular-aneurysms-in-a-rabbit-model
#6
Mark D Meadowcroft, Timothy K Cooper, Sebastian Rupprecht, Thaddeus C Wright, Elizabeth E Neely, Michele Ferenci, Weimin Kang, Qing X Yang, Robert E Harbaugh, James R Connor, James McInerney
OBJECTIVE Intracranial aneurysms are vascular abnormalities associated with neurological morbidity and mortality due to risk of rupture. In addition, many aneurysm treatments have associated risk profiles that can preclude the prophylactic treatment of asymptomatic lesions. Gamma Knife radiosurgery (GKRS) is a standard treatment for trigeminal neuralgia, tumors, and arteriovenous malformations. Aneurysms associated with arteriovenous malformations have been noted to resolve after treatment of the malformation...
January 12, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29327172/identifying-candidates-for-gamma-knife-radiosurgery-among-elderly-patients-with-brain-metastases
#7
Tae Hoon Roh, Mi Sun Choi, Namkyu You, Donghwan Jeong, Ae Hwa Jang, Mi Ra Seo, Sang Ryul Lee, Se-Hyuk Kim
We investigated the outcomes of gamma knife radiosurgery (GKRS) for elderly patients (≥ 65 years) with brain metastases, and identified survival-associated factors. We retrospectively analyzed data from 115 patients treated with GKRS for 1-15 brain metastases. The median patient age was 72 years; most primary tumors were pulmonary (n = 83). The mean lesion volume was 2.1 ± 4.8 mL. A mean dose of 19.3 Gy was delivered to the mean 63.9% isodose line. The median overall survival (OS) was 5.3 months (95% confidence interval [CI] 3...
January 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29327171/efficacy-of-adjuvant-radiotherapy-in-the-intracranial-hemangiopericytoma
#8
Seung Hyuck Jeon, Sung-Hye Park, Jin Wook Kim, Chul-Kee Park, Sun Ha Paek, Il Han Kim
We retrospectively evaluated an efficacy of adjuvant radiotherapy (RT) in the intracranial hemangiopericytoma (HPC) and analyzed prognostic factors influencing treatment outcomes. Among 49 patients diagnosed as localized intracranial HPC between 1995 and 2016, 31 patients received adjuvant RT after surgery; 26 with fractionated RT and 5 with stereotactic radiosurgery using Gamma Knife. After gross total resection (GTR) (n = 32) and subtotal resection (STR) (n = 17), histopathological grade was confirmed to be grade II (n = 9) or grade III (n = 40)...
January 11, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29326290/functional-lesional-neurosurgery-for-tremor-a-systematic-review-and-meta-analysis
#9
REVIEW
Sebastian R Schreglmann, Joachim K Krauss, Jin Woo Chang, Kailash P Bhatia, Georg Kägi
BACKGROUND: This work evaluates the consistency, effect size and incidence of persistent side effects of lesional neurosurgical interventions in the treatment of tremor due to Parkinson's disease (PD), essential tremor (ET), multiple sclerosis (MS) and midbrain lesions. METHODS: Systematic review and meta-analysis according to PRISMA-P guidelines. Random effects meta-analysis of standardised mean difference based on a peer-reviewed protocol (PROSPERO no. CRD42016048049)...
January 11, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29325944/hemorrhagic-cavernous-sinus-hemangioma-with-sudden-onset-abducens-palsy-case-report
#10
Fumihiko Nishimura, Park Young-Su, Ichiro Nakagawa, Shuichi Yamada, Hiroyuki Nakase, Yasushi Nagatomo
BACKGROUND: We report a rare case of hemorrhagic cavernous sinus hemangioma with sudden onset of abducens palsy. CASE DESCRIPTIONS: Sudden onset of diplopia occurred in a 49-year-old female. Head computed tomography (CT) findings revealed a high density mass in the right cavernous sinus with protrusion to the sphenoid sinus. Endoscopic endonasal surgery was performed, though early recurrence was noted. A gamma knife surgical procedure was then performed to prevent early recurrence after histopathological confirmation of cavernous sinus hemangioma...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29319131/temozolomide-therapy-for-aggressive-pituitary-crooke-s-cells-corticotropinoma-causing-cushing-s-disease-a-case-report-with-literature-review
#11
Aleksandra Gilis-Januszewska, Małgorzata Wilusz, Jacek Pantofliński, Renata Turek-Jabrocka, Grzegorz Sokołowski, Anna Sowa-Staszczak, Łukasz Kluczyński, Dorota Pach, Grzegorz Zieliński, Alicja Hubalewska-Dydejczyk
AbstractContext: Aggressive pituitary tumours causing Cushing's Disease are very rare, difficult to treat, and usually resistant to conventional therapy. There is growing evidence for the use of temozolomide (TZM), an alkylating chemotherapeutic agent, as first line chemotherapy in tumours resistant to repeated neurosurgery, radiotherapy and adrenalectomy. OBJECTIVE: To present the response to TMZ in a rare case of an aggressive pituitary tumour in the course of Cushing's Disease and to review the literature referring to similar cases...
January 10, 2018: Endokrynologia Polska
https://www.readbyqxmd.com/read/29318507/mid-term-prognosis-of-non-functioning-pituitary-adenomas-with-high-proliferative-potential-really-an-aggressive-variant
#12
Yoshikazu Ogawa, Hidefumi Jokura, Kuniyasu Niizuma, Teiji Tominaga
Pituitary adenomas with high proliferation rate and rapid growth are well known, but the clinical characteristics, prognosis, and treatment algorithm remain unclear. The clinical characteristics and mid-term prognosis of patients with non-functioning pituitary adenomas with high proliferative potential were retrospectively investigated. This study identified 53 patients with Ki-67 labeling index of > 3% among 845 patients with non-functioning pituitary adenoma (6.3%) initially treated by surgery. Prophylactic treatment was not applied for patients with residual tumor, but salvage treatment was performed if tumor progression was identified within the follow-up period...
January 9, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29309637/congress-of-neurological-surgeons-systematic-review-and-evidence-based-guidelines-on-the-role-of-radiosurgery-and-radiation-therapy-in-the-management-of-patients-with-vestibular-schwannomas
#13
Isabelle M Germano, Jason Sheehan, Johnathan Parish, Tyler Atkins, Anthony Asher, Constantinos G Hadjipanayis, Stuart H Burri, Sheryl Green, Jeffrey J Olson
Question: What are the indications for stereotactic radiosurgery (SRS) treatment vs observation for patients with intracanalicular vestibular schwannomas without evidence of radiographic progression? Recommendation: Level 3: If tinnitus is not observed at presentation, it is recommended that intracanalicular vestibular schwannomas and small tumors (<2 cm) without tinnitus be observed as observation does not have a negative impact on tumor growth or hearing preservation compared to treatment...
December 20, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29288859/in-reply-to-the-letter-to-the-editor-regarding-who-grade-ii-meningiomas-the-role-of-adjuvant-salvage-gamma-knife-surgery-after-initial-surgery-and-prognostic-factor-assessment
#14
Xueyou Liu, Baoyin Shan, Mengmeng Wang, Jianguo Xu
No abstract text is available yet for this article.
December 27, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29248377/management-of-a-complex-intracranial-arteriovenous-malformation-with-gamma-knife-radiosurgery-a-case-report-with-review-of-literature
#15
Shyamal C Bir, Subhas K Konar, Devi P Patra, Tanmoy K Maiti, Alireza Minagar, Anil Nanda
The risks and benefits of arteriovenous malformation (AVM) treatment should be considered cautiously in each patient since management strategy of it depends on various factors including age of the patient, location and volume of AVM and presence of other vascular abnormalities. Current management options of AVM include observation, endovascular embolization, radiosurgery and microsurgical resection or in combination of any two of the above procedures. Here, we have discussed a case of intracranial AVM with radiation induced early cyst formation, and performed a literature review to determine the optimum treatment of complex intracranial AVM...
December 13, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29239214/brainstem-metastases-treated-with-gamma-knife-stereotactic-radiosurgery-the-indiana-university-health-experience
#16
Ajay Patel, Homan Mohammadi, Tuo Dong, Kevin Ren-Yeh Shiue, Douglas Frye, Yi Le, Shaheryar Ansari, Gordon A Watson, James C Miller, Tim Lautenschlaeger
Brainstem metastases offer a unique challenge in cancer treatment, yet stereotactic radiosurgery (SRS) has proven to be an effective modality in treating these tumors. This report discusses the clinical outcomes of patients with brainstem metastases treated at Indiana University with Gamma Knife (GK) radiosurgery from 2008 to 2016. 19 brainstem metastases from 14 patients who had follow-up brain imaging were identified. Median tumor volume was 0.04 cc (range: 0.01-2.0 cc). Median prescribed dose was 17...
December 14, 2017: CNS Oncology
https://www.readbyqxmd.com/read/29234040/efficacy-and-safety-of-stereotactic-radiosurgery-for-pulmonary-metastases-from-osteosarcoma-experience-in-73-patients
#17
Wenxi Yu, Zimei Liu, Lina Tang, Feng Lin, Yang Yao, Zan Shen
Osteosarcoma pulmonary metastases are typically treated with resection and/or chemotherapy. We hypothesize that stereotactic radiosurgery (SRS) can be an alternative to surgery that can achieve high rates of local control with limited toxicity. From January 2005 to December 2013, 73 patients who developed pulmonary metastasis during period of adjuvant chemotherapy or follow-up were analyzed. 33 patients were treated by stereotactic radiosurgery using the body gamma-knife system. A total dose of 50 Gy was delivered at 5 Gy/fraction to the 50% isodose line covering the planning target volume, whereas a total dose of 70 Gy was delivered at 7 Gy/fraction to the gross target volume...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29228343/long-term-outcome-following-stereotactic-radiosurgery-for-glomus-jugulare-tumors-a-single-institution-experience-of-20-years
#18
Mayur Sharma, Antonio Meola, Sushma Bellamkonda, Xuefei Jia, Joshua Montgomery, Samuel T Chao, John H Suh, Lilyana Angelov, Gene H Barnett
BACKGROUND: Glomus jugulare tumors (GJTs) are rare benign tumors, which pose significant treatment challenges due to proximity to critical structures. OBJECTIVE: To evaluate the long-term clinical and radiological outcome in patients undergoing stereotactic radiosurgery (SRS) for GJTs through retrospective study. METHODS: Forty-two patients with 43 GJTs were treated using Gamma Knife radiosurgery (GKRS; Elekta AB, Stockholm, Sweden) at our institute from 1997 to 2016...
December 4, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29228290/letter-primary-modality-for-medically-refractory-trigeminal-neuralgia-microvascular-decompression-or-gamma-knife-therapy
#19
Ravi Sharma, Varidh Katiyar, Hitesh Gurjar
No abstract text is available yet for this article.
December 7, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29226607/comparison-of-the-convolution-algorithm-with-tmr10-for-leksell-gamma-knife-and-dosimetric-verification-with-radiochromic-gel-dosimeter
#20
Petra Osmancikova, Josef Novotny, Jaroslav Solc, Jan Pipek
The Convolution algorithm, implemented in Leksell GammaPlan® ver. Here, 10, is the first algorithm for Leksell Gamma Knife that takes heterogeneities into account and models dose build-up effects close to tissue boundaries. The aim of this study was preliminary comparison of the Convolution and TMR10 algorithms for real clinical cases and dosimetric verification of the algorithms, using measurements in a phantom. A total of 25 patients involved in comparison of the Convolution and TMR10 algorithms were divided into three groups: patients with benign tumors close to heterogeneities, patients with functional disorders, and patients with tumors located far from heterogeneities...
December 10, 2017: Journal of Applied Clinical Medical Physics
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