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https://www.readbyqxmd.com/read/29509111/using-a-modified-delphi-methodology-to-gain-consensus-on-the-use-of-dressings-in-chronic-wounds-management
#1
David Russell, Leanne Atkin, April Betts, Caroline Dowsett, Francis Fatoye, Sarah Gardner, Julie Green, Chris Manu, Tracey McKenzie, Helena Meally, Louise Mitchell, Julie Mullings, Isaac Odeyemi, Andrew Sharpe, Gillian Yeowell, Nancy Devlin
OBJECTIVE: Managing chronic wounds is associated with a burden to patients, caregivers, health services and society and there is a lack of clarity regarding the role of dressings in improving outcomes. This study aimed to provide understanding on a range of topics, including: the definition of chronicity in wounds, the burden of illness, clinical outcomes of reducing healing time and the impact of early interventions on clinical and economic outcomes and the role of matrix metalloproteinases (MMPs) in wound healing...
March 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29487432/effect-of-extrusion-process-on-the-functional-properties-of-high-amylose-corn-starch-edible-films-and-its-application-in-mango-mangifera-indica-l-cv-tommy-atkins
#2
Abraham Calderón-Castro, Misael Odín Vega-García, José de Jesús Zazueta-Morales, Perla Rosa Fitch-Vargas, Armando Carrillo-López, Roberto Gutiérrez-Dorado, Víctor Limón-Valenzuela, Ernesto Aguilar-Palazuelos
Starch is an attractive raw material as ingredient for edible film manufacture because of its low cost, abundant availability, renewability, and biodegradability. Nevertheless, starch based films exhibit several disadvantages such as brittleness and poor mechanical and barrier properties, which restrict its application for food packaging. The use of the extrusion technology as a pretreatment of the casting technique to change the starch structure in order to obtain edible films, may constitute an alternative to generate coatings with good functional properties and maintain longer the postharvest quality and shelf life of fruits...
March 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29483892/efficacy-of-modified-atkins-ketogenic-diet-in-chronic-cluster-headache-an-open-label-single-arm-clinical-trial
#3
Cherubino Di Lorenzo, Gianluca Coppola, Davide Di Lenola, Maurizio Evangelista, Giulio Sirianni, Paolo Rossi, Giorgio Di Lorenzo, Mariano Serrao, Francesco Pierelli
Introduction: Drug-resistant cluster headache (CH) is still an open clinical challenge. Recently, our group observed the clinical efficacy of a ketogenic diet (KD), usually adopted to treat drug-resistant epilepsies, on migraine. Aim: Here, we aim to detect the effect of KD in a group of drug-resistant chronic CH (CCH) patients. Materials and methods: Eighteen drug-resistant CCH patients underwent a 12-week KD (Modified Atkins Diet, MAD), and the clinical response was evaluated in terms of response (≥50% attack reduction)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29396118/clinical-and-cost-effectiveness-of-an-intervention-for-reducing-cholesterol-and-cardiovascular-risk-for-people-with-severe-mental-illness-in-english-primary-care-a-cluster-randomised-controlled-trial
#4
David Osborn, Alexandra Burton, Rachael Hunter, Louise Marston, Lou Atkins, Thomas Barnes, Ruth Blackburn, Thomas Craig, Hazel Gilbert, Samira Heinkel, Richard Holt, Michael King, Susan Michie, Richard Morris, Steve Morris, Irwin Nazareth, Rumana Omar, Irene Petersen, Robert Peveler, Vanessa Pinfold, Kate Walters
BACKGROUND: People with severe mental illnesses, including psychosis, have an increased risk of cardiovascular disease. We aimed to evaluate the effects of a primary care intervention on decreasing total cholesterol concentrations and cardiovascular disease risk in people with severe mental illnesses. METHODS: We did this cluster randomised trial in general practices across England, with general practices as the cluster unit. We randomly assigned general practices (1:1) with 40 or more patients with severe mental illnesses using a computer-generated random sequence with a block size of four...
January 15, 2018: Lancet Psychiatry
https://www.readbyqxmd.com/read/29289395/modified-false-profile-radiograph-of-the-hip-provides-better-visualization-of-the-anterosuperior-femoral-head-neck-junction
#5
Penny R Atkins, Evangeline F Kobayashi, Andrew E Anderson, Stephen K Aoki
PURPOSE: The purpose of this study was to quantify the amount of internal femur rotation required to visualize the 12 to 3 o'clock positions of the femoral head-neck junction as seen on the false-profile radiograph. METHODS: Computed tomography (CT) images of the femur were retrospectively reviewed from control subjects and cam femoroacetabular impingement (FAI) patients. Using an automatically determined clockface, the positions between 12 and 3 o'clock were determined...
December 27, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29288188/efficacy-and-safety-of-chimeric-antigen-receptor-t-cell-car-t-therapy-in-patients-with-haematological-and-solid-malignancies-protocol-for-a-systematic-review-and-meta-analysis
#6
Emma J M Grigor, Dean A Fergusson, Fatima Haggar, Natasha Kekre, Harold Atkins, Risa Shorr, Robert A Holt, Brian Hutton, Tim Ramsay, Matthew Seftel, Derek Jonker, Mads Daugaard, Kednapa Thavorn, Justin Presseau, Manoj M Lalu
INTRODUCTION: Patients with relapsed or refractory malignancies have a poor prognosis. Immunotherapy with chimeric antigen receptor T (CAR-T) cells redirects a patient's immune cells against the tumour antigen. CAR-T cell therapy has demonstrated promise in treating patients with several haematological malignancies, including acute B-cell lymphoblastic leukaemia and B-cell lymphomas. CAR-T cell therapy for patients with other solid tumours is also being tested. Safety is an important consideration in CAR-T cell therapy given the potential for serious adverse events, including death...
December 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/29185808/lipid-modifying-activity-of-curcuminoids-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#7
Luis E Simental-Mendía, Matteo Pirro, Antonio M Gotto, Maciej Banach, Stephen L Atkin, Muhammed Majeed, Amirhossein Sahebkar
OBJECTIVE: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. METHODS: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd , 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method...
November 29, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29129666/effect-of-soy-isoflavone-supplementation-on-plasma-lipoprotein-a-concentrations-a-meta-analysis
#8
REVIEW
Luis E Simental-Mendía, Antonio M Gotto, Stephen L Atkin, Maciej Banach, Matteo Pirro, Amirhossein Sahebkar
BACKGROUND: Soy supplementation has been shown to reduce total and low-density lipoprotein cholesterol, while increasing high-density lipoprotein cholesterol. However, contradictory effects of soy isoflavone supplementation on lipoprotein(a) [Lp(a)] have been reported suggesting the need for a meta-analysis to be undertaken. OBJECTIVE: The aim of the study was to investigate the impact of supplementation with soy isoflavones on plasma Lp(a) levels through a systematic review and meta-analysis of eligible randomized placebo-controlled trials...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29110599/effect-of-metformin-on-plasma-fibrinogen-concentrations-a-systematic-review-and-meta-analysis-of-randomized-placebo-controlled-trials
#9
Luis E Simental-Mendia, Matteo Pirro, Stephen L Atkin, Maciej Banach, Dimitri P Mikhailidis, Amirhossein Sahebkar
OBJECTIVE: Fibrinogen is a key mediator of thrombosis and it has been implicated in the pathogenesis of atherosclerosis. Because metformin has shown a potential protective effect on different atherothrombotic risk factors, we assessed in this meta-analysis its effect on plasma fibrinogen concentrations. METHODS: A systematic review and meta-analysis was carried out to identify randomized placebo-controlled trials evaluating the effect of metformin administration on fibrinogen levels...
November 3, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29069983/short-term-and-long-term-efficacy-of-classical-ketogenic-diet-and-modified-atkins-diet-in-children-and-adolescents-with-epilepsy-a-systematic-review-and-meta-analysis
#10
Shahabeddin Rezaei, Ahmed Abdulahi Abdurahman, Amene Saghazadeh, Reza Shervin Badv, Maryam Mahmoudi
OBJECTIVES: Classical ketogenic diet (KD) and modified Atkins diet (MAD) are two types of KD commonly used for the treatment of intractable epilepsy throughout the world. Studies have shown the efficacy of these diets. However, no systematic review and meta-analysis study has to date compared the efficacy of KD and MAD in a time trend. Therefore, the objectives of the present study were to compare the short-term and long-term efficacy of classical KD and MAD in children and adolescents with epilepsy and to determine the efficacy of classical KD and MAD at multiple time points and in a time trend...
October 25, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29062353/why-should-modified-atkins-diet-be-encouraged-for-treating-epilepsy-in-emerging-countries
#11
Amal Satte, Eric Heath Kossoff, Mohamed Belghiti, Abderrahim Zerhouni, Hamid Ouhabi, Hassania Guerinech, Jamal Mounach
No abstract text is available yet for this article.
June 2017: African Health Sciences
https://www.readbyqxmd.com/read/29051341/indoor-tanning-dependence-in-young-adult-women
#12
Darren Mays, Michael B Atkins, Jaeil Ahn, Kenneth P Tercyak
Background: There is mounting evidence that young people can develop a dependence on indoor tanning, but research on factors associated with indoor tanning dependence remains limited. Methods: This cross-sectional study investigated factors associated with indoor tanning dependence in a community sample of 389 non-Hispanic white young adult women ages 18 to 30 who had indoor tanned ≥1 time in the past year. Participants completed measures of indoor tanning dependence, including the modified CAGE and modified Diagnostic and Statistical Manual for Mental Disorders-IV psychiatric screening assessments, indoor tanning behavior and beliefs, and behavioral and psychiatric comorbidity...
November 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29046197/-prospective-study-of-ketogenic-diet-in-treatment-of-children-with-global-developmental-delay
#13
RANDOMIZED CONTROLLED TRIAL
Deng-Na Zhu, Ping Li, Jun Wang, Jun-Ying Yuan, Guang-Yu Zhang, Jiang-Fang Liang, Ming-Mei Wang, Yun-Xia Zhao, Shuang An, Na Ma, Dan-Dan Ma
OBJECTIVE: To study the effect of ketogenic diet (KD) on neurobehavioral development, emotional and social behaviors, and life ability in children with global developmental delay (GDD). METHODS: A prospective case-control study was performed for hospitalized children with GDD, who were randomly divided into KD treatment group (n=40) and conventional treatment group (n=37). The children in both groups were given comprehensive rehabilitation training, and those in the KD treatment group were given modified Atkins diet in addition to the comprehensive rehabilitation training...
October 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29040030/nivolumab-plus-ipilimumab-in-patients-with-advanced-melanoma-updated-survival-response-and-safety-data-in-a-phase-i-dose-escalation-study
#14
Margaret K Callahan, Harriet Kluger, Michael A Postow, Neil H Segal, Alexander Lesokhin, Michael B Atkins, John M Kirkwood, Suba Krishnan, Rafia Bhore, Christine Horak, Jedd D Wolchok, Mario Sznol
Purpose The clinical activity observed in a phase I dose-escalation study of concurrent therapy with nivolumab (NIVO) and ipilimumab (IPI) in patients with previously treated or untreated advanced melanoma led to subsequent clinical development, including randomized trials. Here, we report long-term follow-up data from study CA209-004, including 3-year overall survival (OS). Patients and Methods Concurrent cohorts 1, 2, 2a, and 3 received escalating doses of NIVO plus IPI once every 3 weeks for four doses, followed by NIVO once every 3 weeks for four doses, then NIVO plus IPI once every 12 weeks for eight doses...
February 1, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29034969/experience-with-mad-on-children-with-epilepsy-in-egypt-after-classic-kd-failure
#15
O F El Rashidy, M F Nassar, Y G El Gendy, S M Deifalla, S Gaballa
BACKGROUND AND AIM: Modified Atkins diet (MAD) is a less restrictive type of ketogenic diet (KD) as compared to the classic one. The aim of this study was to evaluate the impact of 9 months MAD treatment on the growth and seizure control in patients with intractable epilepsy as well as the quality of life (QoL) of their mothers. SUBJECTS AND METHODS: The study included 15 patients with intractable epilepsy who could not tolerate their classic KD management plan...
February 2018: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28923041/lay-health-workers-perceptions-of-an-anemia-control-intervention-in-karnataka-india-a-qualitative-study
#16
RANDOMIZED CONTROLLED TRIAL
Arun S Shet, Abha Rao, Paul Jebaraj, Maya Mascarenhas, Merrick Zwarenstein, Maria Rosaria Galanti, Salla Atkins
BACKGROUND: Lay health workers (LHWs) are increasingly used to complement health services internationally. Their perceptions of the interventions they implement and their experiences in delivering community based interventions in India have been infrequently studied. We developed a novel LHW led intervention to improve anemia cure rates in rural community dwelling children attending village day care centers in South India. Since the intervention is delivered by the village day care center LHW, we sought to understand participating LHWs' acceptance of and perspectives regarding the intervention, particularly in relation to factors affecting daily implementation...
September 18, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28887259/morphometric-assessment-as-a-predictor-of-outcome-in-older-vascular-surgery-patients
#17
Mohammed M Chowdhury, Graeme K Ambler, Naail Al Zuhir, Alex Walker, Ellie R Atkins, Andrew Winterbottom, Patrick A Coughlin
BACKGROUND: Frailty is a recognized predictor of poor outcome in patients undergoing surgical intervention. Frailty is intricately linked with body morphology, which can be evaluated using morphometric assessment via computerized tomographic (CT) imaging. We aimed to assess the predictive power of such objective assessments in a broad cohort of vascular surgical patients. METHODS: A consecutive series of patients aged over 65 years admitted to a vascular unit, who had undergone CT imaging of the abdomen, were analyzed...
February 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28808808/ketogenic-diet-versus-gluten-free-casein-free-diet-in-autistic-children-a-case-control-study
#18
Omnia El-Rashidy, Farida El-Baz, Yasmin El-Gendy, Randa Khalaf, Dina Reda, Khaled Saad
Many diet regimens were studied for patients with autism spectrum disorder (ASD) over the past few years. Ketogenic diet is gaining attention due to its proven effect on neurological conditions like epilepsy in children. Forty-five children aged 3-8 years diagnosed with ASD based on DSM-5 criteria were enrolled in this study. Patients were equally divided into 3 groups, first group received ketogenic diet as modified Atkins diet (MAD), second group received gluten free casein free (GFCF) diet and the third group received balanced nutrition and served as a control group...
December 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28799513/ketogenic-diets-in-the-treatment-of-epilepsy
#19
Maurizio Elia, Joerg Klepper, Baerbel Leiendecker, Hans Hartmann
BACKGROUND: Although a larger number of antiepileptic drugs became available in the last decades, epilepsy remains drug-resistant in approximately a third of patients. Ketogenic diet (KD), first proposed at the beginning of the last century, is complex and has anticonvulsant effects, yet not completely understood. Over the last decades, different types of ketogenic diets (KDs) have been developed, namely classical KD and modified Atkins diet (MAD). They offer an effective alternative for children and adults with drug-resistant epilepsies...
2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28765041/evidence-for-altered-osteoclastogenesis-in-splenocyte-cultures-from-vdr-knockout-mice
#20
Daniel C Reinke, Yolandi Starczak, Masakazu Kogawa, Kate R Barratt, Howard A Morris, Paul H Anderson, Gerald J Atkins
The indirect action of 1α,25(OH)2 -vitamin-D3 (1,25D) on the osteoclast through stromal signalling is well established. The role of vitamin D in osteoclasts through direct 1,25D-VDR signalling is less well known. We showed previously that local 1,25D synthesis in osteoclasts modified osteoclastogenesis and osteoclastic resorptive activity. In this study, we hypothesised that osteoclasts lacking VDR expression would display an enhanced resorptive capacity due to the loss of 1,25D signalling. Splenocytes were cultured under osteoclast-differentiating conditions from mice with global deletion of the Vdr gene (VDRKO) and this was compared with age-matched wild-type littermate controls (WT)...
March 2018: Journal of Steroid Biochemistry and Molecular Biology
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