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Spinal implant infection

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https://www.readbyqxmd.com/read/29745132/monitoring-metabolic-reactions-in-staphylococcus-epidermidis-exposed-to-silicon-nitride-using-in-situ-time-lapse-raman-spectroscopy
#1
Francesco Boschetto, Tetsuya Adachi, Satoshi Horiguchi, Danny Fainozzi, Fulvio Parmigiani, Elia Marin, Wenliang Zhu, Bryan McEntire, Toshiro Yamamoto, Narisato Kanamura, Osam Mazda, Eriko Ohgitani, Giuseppe Pezzotti
Staphylococcus epidermidis (S. epidermidis) is one of the leading nosocomial pathogens, particularly associated with periprosthetic infections of biomedical implants. Silicon nitride (Si3N4), a nonoxide biomaterial widely used in spinal implants, has shown bacteriostatic effects against both gram-positive and gram-negative bacteria; however, the physicochemical interactions between Si3N4 and bacteria yet remain conspicuously unexplored. In situ time-lapse Raman spectroscopic experiments were conducted by exposing S...
May 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29735145/growth-friendly-surgery-is-effective-at-treating-early-onset-scoliosis-associated-with-goldenhar-syndrome
#2
Braydon Connell, Jonathan J Oore, Joshua M Pahys, George H Thompson, Tricia St Hilaire, Tara Flynn, Ron El-Hawary
OBJECTIVE: To evaluate the radiographic results and complications of growth-friendly (GF) surgery in the treatment of early-onset scoliosis (EOS) associated with Goldenhar syndrome. BACKGROUND: Goldenhar syndrome has been associated with spinal deformity, which may be progressive. Efficacy and complication rate of GF treatment has not been reported for this population of patients with EOS. METHODS: Patients with Goldenhar syndrome and EOS with two years' follow-up were identified from two international multicenter EOS databases...
May 2018: Spine Deformity
https://www.readbyqxmd.com/read/29726795/complication-rates-for-preexisting-baclofen-pumps-and-ventricular-shunts-following-scoliosis-correction-a-preliminary-study
#3
Jonathan Dallas, Katherine D Sborov, Bradley S Guidry, Silky Chotai, Christopher M Bonfield
OBJECTIVE Many patients undergoing spinal fusion for neuromuscular scoliosis have preexisting neurosurgical implants, including ventricular shunts (VSs) for hydrocephalus and baclofen pumps (BPs) for spastic cerebral palsy. Recent studies have discussed a possible increase in implant complication rates following spinal fusion, but published data are inconclusive. The authors therefore, sought to investigate: 1) the rate of implant complications following fusion, 2) possible causes of these complications, and 3) factors that place patients at higher risk for implant-related complications...
May 4, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29689393/peak-timing-for-complications-following-adult-spinal-deformity-surgery
#4
Alan H Daniels, Shay Bess, Breton Line, Adam E M Eltorai, Daniel B C Reid, Virginie Lafage, Behrooz A Akbarnia, Christopher P Ames, Oheneba Boachie-Adjei, Douglas C Burton, Vedat Deviren, Han Jo Kim, Robert A Hart, Khaled M Kebaish, Eric O Klineberg, Munish Gupta, Gregory M Mundis, Richard A Hostin, Michael O'Brien, Frank J Schwab, Christopher I Shaffrey, Justin S Smith
BACKGROUND: Overall complication rates for adult spinal deformity (ASD) surgery have been reported, however little data exists on the peak timing associated with specific complications. This study quantifies the peak timing for multiple complication types in an ASD cohort at minimum 2-year follow up. METHODS: Multi-center, prospective analysis of all complications following ASD surgery in a consecutively enrolled cohort was performed. Inclusion criteria were ASD, age ≥ 18 years, spinal fusion ≥ 4 levels, and minimum 2-year follow-up...
April 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29600907/posterior-approach-single-level-apical-spinal-osteotomy-in-pediatric-patients-for-severe-rigid-kyphoscoliosis-long-term-clinical-and-radiological-outcomes
#5
Ankit Patel, Sameer Ruparel, Tarun Dusad, Gaurav Mehta, Vishal Kundnani
OBJECTIVE Spinal osteotomy in pediatric patients is challenging due to various factors. For correction of severe rigid kyphoscoliosis in children, numerous techniques with anterior or posterior or combined approaches, as well as multilevel osteotomies, have been described. These techniques are associated with prolonged operative times and large amounts of blood loss. The purpose of this study was to evaluate the clinical and radiologically confirmed efficacy of a modification of the apical spinal osteotomy (ASO) technique-posterior-only single-level asymmetric closing osteotomy-in pediatric patients with severe rigid kyphoscoliosis...
March 30, 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29595747/postoperative-infection-in-patients-undergoing-posterior-lumbosacral-spinal-surgery-a-pictorial-guide-for-diagnosis-and-early-treatment
#6
Shih-Hao Chen, Wen-Jer Chen, Meng-Huang Wu, Jen-Chung Liao, Chen-Ju Fu
Surgical site infections after posterior spinal surgery may lead to spondylodiscitis, pseudarthrosis, correction loss, adverse neurological sequelae, sepsis, and poor outcomes if not treated immediately. Infection rates vary depending on the type and extent of operative procedures, use of instrumentation, and patients' risk factors. Image evaluation is crucial for early diagnosis and should be complementary to clinical routes, laboratory survey, and treatment timing. Magnetic resonance imaging detects early inflammatory infiltration into the vertebrae and soft tissues, including hyperemic changes of edematous marrow, vertebral endplate, and abscess or phlegmon accumulation around the intervertebral disk, epidural, and paravertebral spaces...
March 27, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29588607/cost-analysis-of-a-growth-guidance-system-compared-with-traditional-and-magnetically-controlled-growing-rods-for-early-onset-scoliosis-a-us-based-integrated-health-care-delivery-system-perspective
#7
Scott J Luhmann, Eoin M McAughey, Stacey J Ackerman, David B Bumpass, Richard E McCarthy
Purpose: Treating early-onset scoliosis (EOS) with traditional growing rods (TGR) is effective but requires periodic surgical lengthening, risking complications. Alternatives include magnetically controlled growing rods (MCGR) that lengthen noninvasively and the growth guidance system (GGS), which obviate the need for active, distractive lengthenings. Previous studies have reported promising clinical effectiveness for GGS; however the direct medical costs of GGS compared to TGR and MCGR have not yet been explored...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29582969/incidence-and-risk-factors-of-neurosurgical-site-infections-results-of-a-prospective-multicenter-cohort-study-on-6359-surgeries
#8
Laura Valentini, Francesca Chiaffarino, Nicoletta Bonfanti, Marilou Pannacci, Paolo Cortellazzi, Caterina Uberti-Foppa, Marika Furlanetto, Francesco DI Meco, Luca Massimi
OBJECTIVES: Neurosurgical surgical site infections (SSI) are life-threatening complications, requiring medical treatment and additional surgeries and remain a substantial cause of morbidity. In order to identify the incidence and the main risk factors for SSI, we developed the Prophylaxis with Antibiotic protocol for neuroSurgical Site Infections Study (PASSIS), a prospective observational multicenter cohort study for examining a large number of neurosurgical procedures. METHODS: The study PASSIS involved four Italian Neurosurgical Departments applying the same antibiotic prophylaxis (ABP) protocol on 6359 consecutive neurosurgical procedures...
March 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29556679/-infections-after-reconstructive-spinal-interventions-how-do-i-deal-with-them
#9
REVIEW
Burkhard Lehner, Michael Akbar, Nicholas A Beckmann
BASICS: Postoperative surgical site infections of the spine have been described in up to 20% of patients and can result in serious consequences for the patient and substantial treatment costs. Typical bacteria often arise from skin or fecal flora. Various risk factors for infection have been described, including obesity, diabetes, high ASA scores, as well as intraoperative factors such as heavy blood loss, dural tears, or several revision procedures. Consequently, the prophylaxis with pre- and postoperative risk minimization is of particular importance...
March 20, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29535015/combined-pedicle-screw-fixation-at-the-fracture-vertebrae-versus-conventional-method-for-thoracolumbar-fractures-a-meta-analysis
#10
REVIEW
Conghui Zhang, Yang Liu
BACKGROUND: Thoracolumbar fractures is a frequent injury occurring in spinal trauma. Outcomes and complications between combined pedicle screw fixation at the fracture vertebrae (AFV) and conventional method cross the fracture vertebrae (CFV) are still controversial. Thus, this study aimed to evaluate differences in outcome variables between these two operative methods. MATERIALS AND METHODS: PubMed, Web of Science, Cochrane Library, EMBASE and CNKI were searched with the terms "thoracolumbar fractures", "posterior", "pedicle screw fixation", and "clinical trial" from Jan 1980 to July 2017...
March 10, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29498369/-abscesses-in-the-lumbo-sacral-spine-area-a-case-report
#11
Alicja Baranowska, Paweł Baranowski, Tadeusz Płusa
Infection of the surgical operation site is found in approximately 3% of patients and 20% of patients undergoing urgent surgery. The occurrence of this type of complications is affected both by coexisting diseases and the presence of infection in the environment in which the patient is staying. It should also be taken into account that the bacteria found in the implanted material and surrounding tissues have the ability to adhere to the implant, creating a biofilm structure there. The presented patient is an illustration of such a problem, because after L5 laminectomy and extensive L2-L3 and L3-L4 one-sided fenestration and L2-L3-L4-L5 facetectomy, interbody bone arthrodesis and transpedicular stabilization, he reported for fever and pain in right lumbar area...
February 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29452285/risk-factors-for-perioperative-morbidity-in-spine-surgeries-of-different-complexities-a-multivariate-analysis-of-1-009-consecutive-patients
#12
Mazda Farshad, David E Bauer, Cyrill Wechsler, Christian Gerber, Alexander Aichmair
BACKGROUND CONTEXT: There is a broad spectrum of complications during or after surgical procedures, with differing incidences reported in the published literature. Heterogeneity can be explained by the lack of an established evidence-based classification system for documentation and classification of complications in a standardized manner. PURPOSE: The objective of this study was to identify predictive risk factors for perioperative and early postoperative morbidities in spine surgeries of different complexities in a large cohort of consecutive patients...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29372855/placement-of-baclofen-pump-catheter-through-a-c1-2-puncture-technical-note
#13
Zaid Aljuboori, Jacob Archer, Wei Huff, Amee Moreno, Andrew Jea
Intrathecal baclofen has been suggested as an effective and safe treatment for intractable spasticity and dystonia. Techniques of lumbar and intraventricular catheter placement have been previously described. The purpose of this study was to describe a technique to implant catheters for intrathecal baclofen infusion through C1-2 puncture. Four of 5 consecutively treated patients underwent successful placement of catheters for intrathecal baclofen. There were no instances of infection, CSF leak, or catheter migration seen during a follow-up period of at least 6 months; furthermore, there were no occurrences of vertebral artery or spinal cord injury...
April 2018: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/29368319/is-implant-washing-and-wound-irrigation-with-rifampicin-effective-for-preventing-surgical-site-infections-in-lumbar-instrumentation
#14
Numan Karaarslan, Ibrahim Yilmaz, Hanefi Ozbek, Mehmet Sabri Gurbuz, Kadir Oznam, Ozkan Ates, Ilknur Erdem
AIM: The aim of this study was to determine whether the washing of implants and autogenous bone grafts with rifampicin, and the irrigation of the surgical field using diluted rifampicin, have any significant effect on the prevention of spinal implant infections. MATERIAL AND METHODS: A total of 166 consecutive lumbar stenosis and spondylolisthesis patients undergoing lumbar instrumentation between 2012 and 2016 were analyzed retrospectively. The patients were divided into two groups...
December 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/29304115/effects-of-a-self-assembling-peptide-as-a-scaffold-on-bone-formation-in-a-defect
#15
Kei Ando, Shiro Imagama, Kazuyoshi Kobayashi, Kenyu Ito, Mikito Tsushima, Masayoshi Morozumi, Satoshi Tanaka, Masaaki Machino, Kyotaro Ota, Koji Nishida, Yoshihiro Nishida, Naoki Ishiguro
Spinal fusion and bone defect after injuries, removal of bone tumors, and infections need to be repaired by implantation. In an aging society, recovery from these procedures is often difficult. In this study, we found that injection of SPG-178 leads to expression of several bone marker genes and mineralization in vitro, and revealed a significantly higher degree of newly formed bone matrix with use of SPG-178 in vivo. MC3T3-E1 cells were used to evaluate osteoblast differentiation promoted by SPG-178. To analyze gene expression, total RNA was isolated from MC3T3-E1 cells cultured for 7 and 14 days with control medium or SPG-178 medium...
2018: PloS One
https://www.readbyqxmd.com/read/29190173/detection-of-bacteria-colonizing-titanium-spinal-implants-in-children
#16
Leonie Wagner, Lena Braunschweig, Helmut Eiffert, Konstantinos Tsaknakis, Dirk Kamin, Elisa D'Este, Philipp K Messer, Anna Kathrin Hell, Heiko M Lorenz
BACKGROUND: Bacterial colonization of spinal implants may cause severe complications in patients with early-onset scoliosis. Correct diagnosis and detection of microbiologic formation is crucial to prevent delayed infections caused by bacterial colonization. The purposes of this study were to estimate the rate and risk factors of colonization of vertical expandable prosthetic titanium rib (VEPTR) implants in children and to compare the different methods for detecting microbiologic formation on the spinal implants...
January 2018: Surgical Infections
https://www.readbyqxmd.com/read/29102375/-male-neurogenic-stress-urinary-incontinence-treated-by-artificial-urinary-sphincter-ams-800%C3%A2-boston-scientific-boston-usa-very-long-term-results-25-years
#17
C Guillot-Tantay, E Chartier-Kastler, P Mozer, M-O Bitker, F Richard, V Ambrogi, P Denys, P Léon, V Phé
OBJECTIVE: The aim of the study was to report the very long-term functional outcomes of artificial urinary sphincter (AUS) in male neurological patients. MATERIAL AND METHODS: Male neurological patients diagnosed with stress urinary incontinence due to sphincter deficiency and undergoing AUS (AMS 800® ) implantation between 1985 and 1992 were enrolled. Continence, defined by no pad/condom usage, explantation and revision rates were reported. RESULTS: Fourteen patients with a median age of 27...
January 2018: Progrès en Urologie
https://www.readbyqxmd.com/read/29057348/navigation-accuracy-comparing-non-covered-frame-and-use-of-plastic-sterile-drapes-to-cover-the-reference-frame-in-3d-acquisition
#18
Donald S Corenman, Eric L Strauch, Grant J Dornan, Eric Otterstrom, Lisa Zalepa King
BACKGROUND: Advancements in surgical navigation technology coupled with 3-dimensional (3D) radiographic data have significantly enhanced the accuracy and efficiency of spinal fusion implant placement. Increased usage of such technology has led to rising concerns regarding maintenance of the sterile field, as makeshift drape systems are fraught with breaches thus presenting increased risk of surgical site infections (SSIs). A clinical need exists for a sterile draping solution with these techniques...
September 2017: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/29037974/impact-of-early-unanticipated-revision-surgery-on-health-related-quality-of-life-after-adult-spinal-deformity
#19
Susana Núñez-Pereira, Alba Vila-Casademunt, Montse Domingo-Sàbat, Juan Bagó, Emre R Acaroglu, Ahmet Alanay, Ibrahim Obeid, Francisco Javier Sánchez Pérez-Grueso, Frank Kleinstück, Ferran Pellisé
Background context Revision surgery represents a major event for patients undergoing ASD surgery. Previous reports suggest minimal or no impact on HRQOL outcomes. Purpose To investigate the impact of early reoperations within the first year on health-related quality of life (HRQOL) and on the likelihood of reaching the MCID after ASD surgery. Design Retrospective analysis of prospectively collected data from consecutive surgically treated adult deformity surgery (ADS) patients included in a multicenter, international database...
October 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29033574/surgical-site-infections-following-instrumented-stabilization-of-the-spine
#20
Ulrike Dapunt, Caroline Bürkle, Frank Günther, Wojciech Pepke, Stefan Hemmer, Michael Akbar
BACKGROUND: Implant-associated infections are still a feared complication in the field of orthopedics. Bacteria attach to the implant surface and form so-called biofilm colonies that are often difficult to diagnose and treat. Since the majority of studies focus on prosthetic joint infections (PJIs) of the hip and knee, current treatment options (eg, antibiotic prophylaxis) of implant-associated infections have mostly been adapted according to these results. OBJECTIVE: The aim of this study was to evaluate patients with surgical site infections following instrumented stabilization of the spine with regard to detected bacteria species and the course of the disease...
2017: Therapeutics and Clinical Risk Management
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