Guohui Zhang, Juncen Guo, Haoxuan Yang, Qing Li, Fei Ye, Yuelin Song, Dongsheng Xiong, Jiuzhi Zeng, Weiwei Zhi, Shuiqiao Yuan, Yunyun Lv, Tongtong Li, Yan Wang, Lu Liao, Dong Deng, Weixin Liu, Wenming Xu
In our prior investigation, we discerned loss-of-function variants within the gene encoding glutamine-rich protein 2 (QRICH2) in two consanguineous families, leading to various morphological abnormalities in sperm flagella and male infertility. The Qrich2 knockout (KO) in mice also exhibits multiple morphological abnormalities of the flagella (MMAF) phenotype with a significantly decreased sperm motility. However, how ORICH2 regulates the formation of sperm flagella remains unclear. Abnormal glutamylation levels of tubulin cause dysplastic microtubules and flagella, eventually resulting in the decline of sperm motility and male infertility...
April 10, 2024: Cellular and Molecular Life Sciences: CMLS