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https://www.readbyqxmd.com/read/28820406/-results-of-preparation-and-implementation-of-ivf-program-in-patients-with-thrombophilia-and-history-of-failed-ivf
#1
G Abrahamyan
The problem of infertility and reproductive losses maintains its urgency, as well as medical and social significance. Frequency of infertility in overall population, according to the data from different authors, varies from 9 to 18 per cent. Methods of aided reproductive technologies (ART) opened a new era in the field of correction of infertile marriage. As a result, more and more couples choose to solve this problem by means of aided reproductive technologies (ART): in-vitro fertilization (IVF) and embryo transfer (ET)...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28801929/validation-and-application-of-a-novel-integrated-genetic-screening-method-to-a-cohort-of-1-112-men-with-idiopathic-azoospermia-or-severe-oligozoospermia
#2
Manon S Oud, Liliana Ramos, Moira K O'Bryan, Robert I McLachlan, Özlem Okutman, Stephane Viville, Petra F de Vries, Dominique F C M Smeets, Dorien Lugtenberg, Jayne Y Hehir-Kwa, Christian Gilissen, Maartje van de Vorst, Lisenka E L M Vissers, Alexander Hoischen, Aukje M Meijerink, Kathrin Fleischer, Joris A Veltman, Michiel J Noordam
Microdeletions of the Y chromosome (YCMs), Klinefelter syndrome (47,XXY) and CFTR mutations are known genetic causes of severe male infertility, but the majority of cases remain idiopathic. Here we describe a novel method using single molecule Molecular Inversion Probes (smMIPs), to screen infertile men for mutations and copy number variations (CNVs) affecting known disease genes. We designed a set of 4,525 smMIPs targeting the coding regions of causal (n = 6) and candidate (n = 101) male infertility genes...
August 11, 2017: Human Mutation
https://www.readbyqxmd.com/read/28761781/the-difference-in-expression-of-long-noncoding-rnas-in-rat-semen-induced-by-high-fat-diet-was-associated-with-metabolic-pathways
#3
Tian An, Hui Fan, Yu F Liu, Yan Y Pan, Ying K Liu, Fang F Mo, Yu J Gu, Ya L Sun, Dan D Zhao, Na Yu, Yue Ma, Chen Y Liu, Qiu L Wang, Zheng Y Li, Fei Teng, Si Hua Gao, Guang J Jiang
BACKGROUND: Obesity, a common metabolic disease, is a known cause of male infertility due to its associated health risk. Long noncoding RNAs (lncRNAs) have also been reported to be associated with male reproductive diseases; however, their role in the association between high-fat diet-induced obesity (DIO) and male reproduction remains unclear. METHODS: We used microarray analysis to compare the expression levels of lncRNAs and mRNAs in the spermatozoa of rats with DIO and normal rats...
2017: PeerJ
https://www.readbyqxmd.com/read/28754299/antimicrobial-resistance-in-neisseria-gonorrhoeae-history-molecular-mechanisms-and-epidemiological-aspects-of-an-emerging-global-threat
#4
REVIEW
Ana Paula Ramalho da Costa-Lourenço, Késia Thaís Barros Dos Santos, Beatriz Meurer Moreira, Sergio Eduardo Longo Fracalanzza, Raquel Regina Bonelli
Neisseria gonorrhoeae is the agent of gonorrhea, a sexually transmitted infection with an estimate from The World Health Organization of 78 million new cases in people aged 15-49 worldwide during 2012. If left untreated, complications may include pelvic inflammatory disease and infertility. Antimicrobial treatment is usually effective; however, resistance has emerged successively through various molecular mechanisms for all the regularly used therapeutic agents throughout decades. Detection of antimicrobial susceptibility is currently the most critical aspect for N...
July 12, 2017: Brazilian Journal of Microbiology: [publication of the Brazilian Society for Microbiology]
https://www.readbyqxmd.com/read/28754128/does-air-pollution-play-a-role-in-infertility-a-systematic-review
#5
REVIEW
Julie Carré, Nicolas Gatimel, Jessika Moreau, Jean Parinaud, Roger Léandri
BACKGROUND: Air pollution is involved in many pathologies. These pollutants act through several mechanisms that can affect numerous physiological functions, including reproduction: as endocrine disruptors or reactive oxygen species inducers, and through the formation of DNA adducts and/or epigenetic modifications. We conducted a systematic review of the published literature on the impact of air pollution on reproductive function. Eligible studies were selected from an electronic literature search from the PUBMED database from January 2000 to February 2016 and associated references in published studies...
July 28, 2017: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/28753682/a-new-computational-strategy-for-identifying-essential-proteins-based-on-network-topological-properties-and-biological-information
#6
Chao Qin, Yongqi Sun, Yadong Dong
Essential proteins are the proteins that are indispensable to the survival and development of an organism. Deleting a single essential protein will cause lethality or infertility. Identifying and analysing essential proteins are key to understanding the molecular mechanisms of living cells. There are two types of methods for predicting essential proteins: experimental methods, which require considerable time and resources, and computational methods, which overcome the shortcomings of experimental methods. However, the prediction accuracy of computational methods for essential proteins requires further improvement...
2017: PloS One
https://www.readbyqxmd.com/read/28744640/features-of-lipoperoxidation-antioxidant-defense-and-thiol-disulfide-system-in-the-pathogenesis-of-infertility-in-males-carriers-of-nonfunctional-variants-of-gstt1-and-gstm1-gene-polymorphisms
#7
L I Kolesnikova, N A Kurashova, T A Bairova, M I Dolgikh, O A Ershova, L V Natyaganova, B G Dashiev, I N Gutnik, N V Koroleva
Comparative analysis of the parameters of LPO, antioxidant defense (AOD), and the thiol/disulfide system was performed in fertile and infertile males of reproductive age carrying different genotypes of the glutathione system genes. Blood plasma, blood hemolysate, and ejaculate served as specimens for biochemical studies. A decrease in glutathione S-transferase activity was found in blood and ejaculate specimens from fertile and infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes. In infertile carriers of nonfunctional GSTT1(0/0)/GSTM1(0/0) genotypes determining reduced glutathione S-transferase activity, a decrease in the concentration of low-molecular-weight cell antioxidant (reduced glutathione) and an increase in the concentration of secondary LPO products (TBA-reactive substances) were revealed...
July 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28743519/the-molecular-complexity-of-primary-ovarian-insufficiency-aetiology-and-the-use-of-massively-parallel-sequencing
#8
REVIEW
Paul Laissue
Primary ovarian insufficiency (POI) is a frequently occurring pathology, leading to infertility. Genetic anomalies have been described in POI and mutations in numerous genes have been definitively related to the pathogenesis of the disease. Some studies based on next generation sequencing (NGS) have been successfully undertaken as they have led to identify new mutations associated with POI aetiology. The purpose of this review is to present the most relevant molecules involved in diverse complex pathways, which may contribute towards POI...
July 23, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28742586/summary-of-future-developments
#9
Jessica R Zolton, Alan Decherney
Endometriosis is a chronic disease with the potential to cause devastating clinical manifestations such as infertility and chronic pelvic disease. Current treatment is limited to surgical intervention and pharmacologic therapy targeting estrogen and progesterone to suppress ectopic endometrial tissue proliferation. Undesired side effects and contraindications to the use of hormonal medications may reduce treatment options. As the pathogenesis of endometriosis continues to be investigated, new therapies will emerge...
September 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28738285/molecular-assessment-characterization-and-differentiation-of-theca-stem-cells-imply-the-presence-of-mesenchymal-and-pluripotent-stem-cells-in-sheep-ovarian-theca-layer
#10
Samane Adib, Mojtaba Rezazadeh Valojerdi
The ability of ovarian theca stem cells to differentiate into oocyte and theca cells may lead to a major advancement in reproductive biology and infertility treatments. However, there is little information about function, growth and differentiation potential of these immature cells. In this study adult sheep theca stem cells (TSCs) characteristics, and differentiation potential into osteocyte-like cells (OSLCs), adipocyte-like cells (ALCs), theca progenitor-like cells (TPCs), and oocyte-like cells (OLCs) were investigated...
July 8, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28715292/brucella-infection-in-asian-sea-otters-enhydra-lutris-lutris-on-bering-island-russia
#11
Tristan L Burgess, Christine Kreuder Johnson, Alexander Burdin, Verena A Gill, Angela M Doroff, Pamela Tuomi, Woutrina A Smith, Tracey Goldstein
Infection with Brucella spp., long known as a cause of abortion, infertility, and reproductive loss in domestic livestock, has increasingly been documented in marine mammals over the past two decades. We report molecular evidence of Brucella infection in Asian sea otters (Enhydra lutris lutris). Brucella DNA was detected in 3 of 78 (4%) rectal swab samples collected between 2004 and 2006 on Bering Island, Russia. These 78 animals had previously been documented to have a Brucella seroprevalence of 28%, markedly higher than the prevalence documented in sea otters (Enhydra lutris) in North America...
July 17, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28712079/aryl-hydrocarbon-receptor-gene-transitions-c-742c-t-c-1661g-a-and-idiopathic-male-infertility-a-case-control-study-with-in-silico-and-meta-analysis
#12
Younes Aftabi, Abasalt Hosseinzadeh Colagar, Faramarz Mehrnejad, Ensiyeh Seyedrezazadeh, Emadoddin Moudi
Aryl hydrocarbon receptor (AHR) is responsible for crucial events in male reproductive biology. Here, the association of the AHR transitions c.-742C>T and c.1661G>A with idiopathic male infertility was investigated in a case-control study, which is followed by a meta-analysis and a bioinformatic investigation. Blood and semen samples were obtained from a total of 135 idiopathic infertile men and 130 healthy controls. Participants were genotyped for the transitions using a PCR-RFLP method. A meta-analysis of five sets of data evaluated the association of c...
July 15, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28711945/the-molecular-characterization-of-porcine-egg-precursor-cells
#13
Te-Sha Tsai, Jacqueline Johnson, Yvonne White, Justin C St John
Female-factor infertility can be caused by poor oocyte quality and depleted ovarian reserves. Egg precursor cells (EPCs), isolated from the ovarian cortex, have the potential to be used to overcome female infertility. We aimed to define the origins of EPCs by analyzing their gene expression profiles and mtDNA content using a mini-pig model. We characterized FAC-sorted DDX4+-derived porcine EPCs by performing RNA-sequencing and determined that they utilize pathways important for cell cycle and proliferation, which supports the existence of adult mitotically active oogonial cells...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28711440/prevalence-of-cervical-colonization-by-ureaplasma-parvum-ureaplasma-urealyticum-mycoplasma-hominis-and-mycoplasma-genitalium-in-childbearing-age-women-by-a-commercially-available-multiplex-real-time-pcr-an-italian-observational-multicentre-study
#14
Christian Leli, Antonella Mencacci, Maria Agnese Latino, Pierangelo Clerici, Mario Rassu, Stefano Perito, Roberto Castronari, Eleonora Pistoni, Eugenio Luciano, Daniela De Maria, Cristina Morazzoni, Michela Pascarella, Silvia Bozza, Alessandra Sensini
BACKGROUND: Mycoplasmas are frequently isolated from the genital tract. New molecular PCR-based methods for the detection of mycoplasmas can better define the real epidemiology of these microorganisms. The aim of this study was to evaluate the prevalence of mycoplasmas in a population of childbearing age women by means of PCR. METHODS: This 21-month multicentre observational study was conducted at four Italian clinical microbiology laboratories. Women reporting symptoms of vaginitis/cervicitis, or with history of infertility, pregnancy, miscarriage or preterm birth were included...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28700985/genes-involved-in-long-term-memory-are-expressed-in-testis-of-cryptorchid-boys-and-respond-to-gnrha-treatment
#15
Faruk Hadziselimovic, Katharina Gegenschatz-Schmid, Gilvydas Verkauskas, Philippe Demougin, Vytautas Bilius, Darius Dasevicius, Michael B Stadler
It has been known for many years that boys with unilateral or bilateral undescended testis (cryptorchidism) tend to have a low IQ, and those who belong to the high infertility risk (HIR) group perform less well at school than low infertility risk (LIR) patients. However, the molecular biological processes underlying this phenomenon are not understood. In this study, we report the outcome of testicular RNA profiling for genes involved in long-term memory formation. We analyzed the histology and the transcriptome of testicular biopsies from bilateral HIR cryptorchid boys, comparing those who received GnRHa treatment for 6 months after the first surgery with those who did not receive GnRHa before the second surgery...
2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/28694462/transgenerational-inheritance-of-susceptibility-to-diabetes-induced-male-subfertility
#16
Gabriela Pavlinkova, Hasmik Margaryan, Eva Zatecka, Eliska Valaskova, Fatima Elzeinova, Alena Kubatova, Romana Bohuslavova, Jana Peknicova
Male infertility is a worldwide problem associated with genetic background, environmental factors, and diseases. One of the suspected contributing factors to male infertility is diabetes mellitus. We investigated the molecular and morphological changes in sperms and testicular tissue of diabetic males. The study was performed in streptozotocin-induced type 1 diabetes mouse model. Diabetes decreased sperm concentration and viability and increased sperm apoptosis. Changes in protamine 1/protamine 2 ratio indicated reduced sperm quality...
July 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693952/pathogenesis-of-adenomyosis-an-update-on-molecular-mechanisms
#17
REVIEW
Silvia Vannuccini, Claudia Tosti, Francisco Carmona, S Joseph Huang, Charles Chapron, Sun-Wei Guo, Felice Petraglia
Adenomyosis is a uterine disorder becoming more commonly diagnosed in women of reproductive age because of diagnostic imaging advancements. The new epidemiological scenario and the clinical evidence of pelvic pain, abnormal uterine bleeding and infertility are changing the classic perspective of adenomyosis as a premenopausal disease. In the last decade, the evaluation of multiple molecular mediators has improved our knowledge of pathogenic mechanisms of adenomyosis, supporting that this is an independent disease from endometriosis...
June 27, 2017: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/28690291/geminin-deletion-in-pre-meiotic-dna-replication-stage-causes-spermatogenesis-defect-and-infertility
#18
Yue Yuan, Xue-Shan Ma, Qiu-Xia Liang, Zhao-Yang Xu, Lin Huang, Tie-Gang Meng, Fei Lin, Heide Schatten, Zhen-Bo Wang, Qing-Yuan Sun
Geminin plays a critical role in cell cycle regulation by regulating DNA replication and serves as a transcriptional molecular switch that directs cell fate decisions. Spermatogonia lacking Geminin disappear during the initial wave of mitotic proliferation, while geminin is not required for meiotic progression of spermatocytes. It is unclear whether geminin plays a role in pre-meiotic DNA replication in later-stage spermatogonia and their subsequent differentiation. Here, we selectively disrupted Geminin in the male germline using the Stra8-Cre/loxP conditional knockout system...
July 9, 2017: Journal of Reproduction and Development
https://www.readbyqxmd.com/read/28674502/treatment-of-abnormal-vaginal-microbiota-before-frozen-embryo-transfer-case-report-and-minireview-to-discuss-the-longitudinal-treatment-efficacy-of-oral-clindamycin
#19
Thor Haahr, Helle O Elbaek, Rita J Laursen, Birgit Alsbjerg, Jørgen S Jensen, Peter Humaidan
Abnormal vaginal microbiota (AVM) or bacterial vaginosis (BV) might negatively impact reproductive outcomes of in vitro fertilization (IVF). However, before randomized controlled trials are initiated to investigate cause and effect, it is necessary to establish the optimal treatment for AVM. Metronidazole seems ineffective to treat the biofilm in AVM; thus, clindamycin could be suggested as a relevant antibiotic agent for future intervention based studies. In the present case report, we present the first longitudinal follow-up of the vaginal microbiota with molecular methods during and after oral clindamycin treatment...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28667793/physiological-mechanisms-through-which-heat-stress-compromises-reproduction-in-pigs
#20
REVIEW
Jason W Ross, Benjamin J Hale, Jacob T Seibert, Matthew R Romoser, Malavika K Adur, Aileen F Keating, Lance H Baumgard
Seasonal variations in environmental temperatures impose added stress on domestic species bred for economically important production traits. These heat-mediated stressors vary on a seasonal, daily, or spatial scale, and negatively impact behavior and reduce feed intake and growth rate, which inevitably lead to reduced herd productivity. The seasonal infertility observed in domestic swine is primarily characterized by depressed reproductive performance, which manifests as delayed puberty onset, reduced farrowing rates, and extended weaning-to-estrus intervals...
July 1, 2017: Molecular Reproduction and Development
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