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Actinic keratoses

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https://www.readbyqxmd.com/read/29785331/nodular-basal-cell-carcinoma-of-the-face-successfully-treated-with-ingenol-mebutate-0-015-gel
#1
Silvia S Iannazzone, Vito Ingordo
Surgical excision is the first-choice treatment for basal cell carcinoma (BCC). Other treatments with topical agents such as 5-fluorouracil or imiquimod have also been suggested for use in superficial BCC (sBCC). Ingenol mebutate (IM) is a novel agent employed in the treatment of superficial actinic keratoses. The drug has been also successfully used in the treatment of sBCC. A case of large nodular BCC (nBCC) of the face in a 100-year-old inoperable woman is described. IM 0.015% gel was applied once daily for three consecutive days...
April 2018: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29782648/patient-preferences-for-topical-treatment-of-actinic-keratoses-a-discrete-choice-experiment
#2
D Kopasker, A Kwiatkowski, R N Matin, C A Harwood, F Ismail, J T Lear, J Thomson, Z Hasan, G N Wali, A Milligan, L Crawford, I Ahmed, H Duffy, C M Proby, P F Allanson
BACKGROUND: Treatment of actinic keratoses (AK) is a potentially effective strategy for prevention of cutaneous squamous cell carcinoma (cSCC). However, the patient perspective on potential benefits of AK treatment in terms of skin cancer reduction has received little attention to date. OBJECTIVES: (1) To investigate patient preferences for AK topical treatments using a discrete choice experiment (DCE); (2) To evaluate patient willingness to trade between clinical benefit and medical burden...
May 21, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29782304/role-of-in-vivo-reflectance-confocal-microscopy-in-the-analysis-of-melanocytic-lesions
#3
Elena-Daniela Serban, Francesca Farnetani, Giovanni Pellacani, Maria Magdalena Constantin
Worldwide melanoma incidence and mortality are increasing (1). Despite the ongoing research, advanced melanoma is still incurable; therefore, the most appropriate solution seems to be early detection combined with complete surgical excision (2). Since the diagnostic protocol of suspicious lesions includes a complete excision with safety margins (2), the problem of unnecessary scarring is significant. The real challenge in this case is to have a properly formulated diagnosis before acquiring a biopsy. Currently available non-invasive techniques are coherence tomography, digital dermoscopy, and reflectance confocal microscopy...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780645/sustained-regression-of-hydroxycarbamide-induced-actinic-keratoses-after-switching-to-anagrelide
#4
Georgios Gaitanis, Dora Gougopoulou, Eleni Kapsali, Ioannis D Bassukas
Hydroxycarbamide (HC) is the first-line treatment for certain myeloproliferative neoplasms, such as polycythemia vera and essential thrombocytosis (ET). In a subset of these patients long-term treatment with HC can result in the development of confluent actinic keratoses (AK) followed by invasive keratinocytic carcinomas ("squamous dysplasia"), preferentially on sun-exposed skin. Discontinuation or dose reduction of HC may result in partial improvement. A 59-year-old farmer after 14 years on HC (2 gr/d) and acetylsalicylic acid (100 mg/d) for ET, was referred for numerous, hyperkeratotic AK on face, scalp, and hands that could not be controlled with repeated ( N = 15) cryosurgery sessions in the previous 3 years...
2018: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/29779986/photodynamic-therapy-corrects-abnormal-cancer-associated-gene-expression-observed-in-actinic-keratosis-lesions-and-induces-a-remodeling-effect-in-photodamaged-skin
#5
Florence Joly, Sophie Deret, Bastien Gamboa, Corinne Menigot, Paul Fogel, Carine Mounier, Pascale Reiniche, Farzaneh Sidou, Jérome Aubert, John Lear, Anthony A Fryer, Francesca Zolezzi, Johannes J Voegel
BACKGROUND: Actinic keratoses (AK) are proliferations of neoplastic keratinocytes in the epidermis resulting from cumulative exposure to ultraviolet radiation (UVR), which are liable to transform into squamous cell carcinoma (SCC). Organ Transplant Recipients (OTR) have an increased risk of developing SCC as a consequence of long-term immunosuppressive therapy. The aim of this study was to determine the molecular signature of AKs from OTR prior to treatment with methyl aminolevulinate-photodynamic therapy (MAL-PDT), and to assess what impact the treatment has on promoting remodeling of the photo-damaged skin...
May 17, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29753305/a-prospective-randomised-within-subject-study-of-ala-pdt-for-actinic-keratoses-using-different-irradiation-regimes
#6
O Zaar, A Sjöholm Hylén, M Gillstedt, J Paoli
BACKGROUND: Photodynamic therapy (PDT) can be used to treat large fields of actinic keratoses (AKs) with high clearance rates. A notable downside is the amount of pain that accompany the treatment. This study aimed to optimise the illumination protocol during conventional PDT in order to reduce pain without compromising treatment effectiveness. METHODS: In this prospective, randomised study with a split-face design, patients with, symmetrically distributed AKs were included...
May 12, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29752702/daylight-photodynamic-therapy-for-actinic-keratoses
#7
REVIEW
Colin A Morton, Lasse R Braathen
Topical photodynamic therapy (PDT) using daylight is effective in the treatment of actinic keratoses (AKs), offering the potential for treatment of large fields such as full face and balding scalp, but with minimal therapy-associated pain. Comparison with conventional PDT indicates similar efficacy for thin and moderate-thickness AKs, but with significantly less discomfort/pain, driving a patient preference for daylight-mediated PDT (DL-PDT) compared with conventional PDT using high-intensity office/hospital-based light sources...
May 11, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29697423/using-stratum-corneum-thickness-and-configuration-to-distinguish-lichenoid-dermatoses
#8
Amanda F Marsch
BACKGROUND: Clues in the stratum corneum (SC) can aide in histopathologic diagnosis of many conditions. OBJECTIVE: To determine if SC configuration and thickness could help differentiate the lichenoid dermatoses. METHODS: A retrospective study was performed. A total of 305 cases (55 lichenoid keratosis, 51 lichen planus, 7 hypertrophic lichen planus, 40 lichenoid drug eruption, 19 lichenoid graft-vs.-host disease, 14 hypertrophic lupus, 46 lichenoid actinic keratosis, 73 lentigo maligna) fulfilled the selection criteria...
April 24, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29696353/-early-detection-of-occupational-skin-diseases-in-sewer-workers
#9
V Lang, F Lauffer, Y Fincan, T Biedermann, A Zink
BACKGROUND: Skin diseases affect 30-70% of the world population, and globally, skin cancer rates are continuously increasing. In this respect, prevention programs and early detection of skin diseases are of particular importance. OBJECTIVES: To screen sewer workers for skin diseases with regard to their work-related risk. METHODS: Employees of the municipal utilities in Munich (Münchner Stadtentwässerung) underwent a whole-body examination of the skin, conducted by two dermatologists...
April 25, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29683291/daylight-pdt-for-field-cancerization-lessons-from-molecular-biology
#10
Max Rybarski, Lutz Schmitz, Ben Novak, Thomas Dirschka
Actinic keratoses (AKs) represent in-situ squamous cell carcinomas that potentially invade subepidermal structures and may metastasize. Until now, it is unpredictable to determine which AK lesions show this aggressive behaviour. As AKs usually occur in large sun exposed areas, field-directed treatments have become the standard treatment regimen. Among these, conventional photodynamic therapy (cPDT) with 5- aminolaevulinic acid (ALA) or methyl-aminolevulinate (MAL) using red light is particularly effective in the treatment of AKs, but acceptance of the therapy is impaired by severe pain during treatment...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29593028/5-fluorouracil-enhances-protoporphyrin-ix-accumulation-and-lesion-clearance-during-photodynamic-therapy-of-actinic-keratoses-a-mechanism-based-clinical-trial
#11
Edward V Maytin, Sanjay Anand, Margo Riha, Sara Lohser, Alejandra Tellez, Rim Ishak, Lauren Karpinski, Janine Sot, Bo Hu, Anton Denisyuk, Scott C Davis, Angela Kyei, Allison Vidimos
PURPOSE: Actinic keratoses (AK) are precancerous lesions that can progress to squamous cell carcinoma. Photodynamic therapy (PDT) and topical 5-fluorouracil (5FU) are commonly used for AK. Empirical reports suggest that combining them can improve the therapeutic response. However, the optimal combined regimen was not clear in terms of proper sequence, timing, and mechanism. This clinical study explored mechanisms of action for neoadjuvantal 5FU and PDT for treatment of AK. EXPERIMENTAL DESIGN: A bilaterally controlled trial (17 patients) was performed...
March 28, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29587662/randomized-clinical-trial-testing-the-efficacy-and-safety-of-0-5-colchicine-cream-versus-photodynamic-therapy-with-methyl-aminolevulinate-in-the-treatment-of-skin-field-cancerization-study-protocol
#12
Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt, Helio Amante Miot
BACKGROUND: The primary clinical manifestation of skin field cancerization is the presence of actinic keratoses (AKs). Current treatments for AKs related to skin field cancerization include photodynamic therapy (PDT) and colchicine. The objective of this study is to evaluate the efficacy and safety of 0.5% colchicine cream versus PDT with methyl aminolevulinate (MAL-PDT) in the treatment of skin field cancerization. METHODS: In a randomized controlled and open clinical trial with a blind histopathological and immunohistochemical analysis, 36 patients with up to 10 AKs on their forearms will be included from the outpatient clinic...
March 27, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29582369/field-cancerization-therapies-for-management-of-actinic-keratosis-a-narrative-review
#13
REVIEW
Nathan Jetter, Neha Chandan, Stephanie Wang, Maria Tsoukas
Actinic keratoses (AKs) are atypical, precancerous proliferations of keratinocytes that develop because of chronic exposure to ultraviolet (UV) radiation. Treatment of AK can be lesion-directed or field-directed. Field cancerization theory postulates that the skin surrounding AK is also at increased risk for possible malignant transformation since it has been exposed to the same chronic UV light. Field-directed therapies thus have the potential to address subclinical damage, reduce AK recurrence rates, and potentially reduce the risk of squamous cell carcinoma (SCC) development...
March 26, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29578627/various-cold-plasma-devices-for-the-treatment-of-actinic-keratosis
#14
P C Friedman, V Miller, G Fridman, A Fridman
We have read with interest the letter entitled "Actinic keratoses treated with cold atmospheric plasma" by Wirtz et al.1 and we are glad to see that other dermatologists are corroborating our February, 20172 report on the use of cold plasma to treat actinic keratoses. We hope this will encourage the use of plasma for other clinical indications. Undoubtedly, a number of new studies of cold plasma treatment of actinic keratoses will appear given the great advantages of this treatment modality. This article is protected by copyright...
March 26, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29575342/actinic-keratoses-seldom-occur-alone
#15
L Schmitz, E Stockfleth
No abstract text is available yet for this article.
April 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29570823/a-pediatric-case-of-squamous-cell-cancer-in-situ-in-the-setting-of-sclerodermatous-graft-versus-host-disease-and-voriconazole-treatment
#16
Alvin W Li, Leah E Lalor, Fernanda Bellodi Schmidt, Minnelly Luu
Sclerodermatous graft-versus-host disease is a subtype of cutaneous chronic graft-versus-host disease that is characterized by sclerosis of the skin and subcutaneous tissue, resulting in debilitating contractures, among other life-threatening complications. Children with sclerodermatous graft-versus-host disease are at high risk of developing nonmelanoma skin cancer because of several risk factors, including young age at transplantation, prolonged immunosuppression, and exposure to photosensitizing antimicrobial prophylaxis such as voriconazole...
March 23, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29537445/intralesional-and-laser-assisted-5-fluorouracil-in-dermatologic-disease-a-systematic-review
#17
Garrett T Prince, Michael C Cameron, Ramin Fathi, Theodore Alkousakis
INTRODUCTION: 5-fluorouracil has proven to be an effective therapy in the treatment of a variety of dermatologic conditions. Approved by the United States Food and Drug Administration for the topical treatment of actinic keratoses and superficial basal cell carcinoma, 5-fluorouracil has also demonstrated efficacy in the treatment of a variety of other dermatologic diseases. While best known for its use as a topical medication, 5-fluorouracil can also be delivered intralesionally for the treatment of dermatologic disease...
March 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29526028/cutaneous-squamous-cell-carcinomas-are-associated-with-basal-proliferating-actinic-keratoses
#18
L Schmitz, T Gambichler, C Kost, G Gupta, M Stücker, E Stockfleth, T Dirschka
BACKGROUND: In addition to the extent of atypical keratinocytes throughout the epidermis, actinic keratoses (AKs) are histologically characterized by downward directed basal layer expansion. It is not known if this growth pattern correlates with the risk of developing invasive squamous cell carcinoma (iSCC). OBJECTIVE: To characterize the prevalence of downward directed basal layer expansion of AKs adjacent to iSCC. METHODS: The epidermis overlying and adjacent to iSCCs was assessed histologically...
March 11, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29485253/daylight-photodynamic-therapy-with-methyl-aminolevulinate-for-the-treatment-of-actinic-keratoses-of-the-forearms
#19
Dario Fai, Carlotta Fai, Nicoletta Cassano, Gino A Vena
No abstract text is available yet for this article.
February 26, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29469794/inflamed-actinic-keratoses-associated-with-pemetrexed-and-carboplatin-therapy
#20
Jimmy Lam, Samantha R Ellis, Raja K Sivamani
Eruptive actinic keratosis (AK) consequent to systemic chemotherapy can be confused with drug allergies. We present the first case of inflamed AKs in one patient after receiving combination therapy with pemetrexed and carboplatin.A 68-year-old woman with non-small cell lung adenocarcinoma (NSCLC) presented with numerous pruritic ill-defined, gritty, erythematous papules consistent with AKs on her upper chest, upper back, and arms two weeks after completing the first cycle of combination therapy with carboplatin and pemetrexed...
October 15, 2017: Dermatology Online Journal
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