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Actinic keratoses

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https://www.readbyqxmd.com/read/28063524/switching-from-conventional-photodynamic-therapy-to-daylight-photodynamic-therapy-for-actinic-keratoses-systematic-review-and-meta-analysis
#1
A Tomás-Velázquez, P Redondo
Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28038885/ultraviolet-radiation-and-the-skin-photobiology-and-sunscreen-photoprotection
#2
Antony R Young, Joël Claveau, Ana Beatris Rossi
The efficacy of sunscreens can be measured by different methods, involving in vitro, ex vivo, or in vivo techniques. There is a need for a worldwide standardization of these methods to avoid misunderstanding and confusion among sunscreen users. The clinical benefits of sunscreens have been demonstrated in randomized controlled trials that established the role of sunscreens in the prevention of actinic keratoses, squamous cell carcinomas, nevi, and melanomas. Sunscreens also prevent photoimmunosuppression and signs of photoaging...
December 23, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27992079/expression-of-claudin-11-by-tumor-cells-in-cutaneous-squamous-cell-carcinoma-is-dependent-on-the-activity-of-p38%C3%AE
#3
Liisa Nissinen, Elina Siljamäki, Pilvi Riihilä, Minna Piipponen, Mehdi Farshchian, Atte Kivisaari, Markku Kallajoki, Laura Raiko, Juha Peltonen, Sirkku Peltonen, Veli-Matti Kähäri
The incidence of cutaneous squamous cell carcinoma (cSCC) is rapidly increasing and the prognosis of patients with metastatic disease is poor. There is an emerging need to identify molecular markers for predicting aggressive behavior of cSCC. Here, we have examined the role of tight junction components in the progression of cSCC. The expression pattern of mRNAs for tight junction components was determined with RNA sequencing and oligonucleotide array-based expression analysis from cSCC cell lines (n=8) and normal human epidermal keratinocytes (NHEK, n=5)...
December 19, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27986142/the-natural-history-of-actinic-keratoses-in-organ-transplant-recipients
#4
Zainab Jiyad, Louise Marquart, Peter O'Rourke, Adele C Green
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27906150/ameluz-for-actinic-keratoses
#5
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2016: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#6
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27832425/histopathologic-pitfalls-of-mohs-micrographic-surgery-and-a%C3%A2-review-of-tumor-histology
#7
REVIEW
Katlein França, Yasser Alqubaisy, Ashraf Hassanein, Keyvan Nouri, Torello Lotti
Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Frozen sections introduce certain artifacts and these artifacts must be interpreted in the correct context. Basal and squamous cell carcinomas are the most common tumors encountered in Mohs micrographic surgery, and their histopathology is also associated with certain "pitfalls"...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27788605/a-consensus-on-the-use-of-daylight-photodynamic-therapy-in-the-uk
#8
Sally Ibbotson, Robin Stones, Jonathan Bowling, Sandra Campbell, Stephen Kownacki, Muthu Sivaramakrishnan, Ronan Valentine, Colin A Morton
BACKGROUND: Actinic keratoses (AKs) are a consequence of chronic exposure to ultraviolet radiation. Treatment of chronically photo-damaged skin and AKs is driven by risk of progression to squamous cell carcinoma, as well as for symptomatic relief. Conventional photodynamic therapy (c-PDT) is indicated when AKs are multiple or confluent and if patients respond poorly or are unable to tolerate other therapies. c-PDT is limited by the field size that can be treated in single sessions and can cause significant discomfort...
October 27, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27778164/effect-of-a-pre-treatment-educational-video-in-improving-patient-satisfaction-with-5-fluorouracil-treatment-for-actinic-keratoses-a-randomized-controlled-trial
#9
Oma N Agbai, Parastoo Davari, Jennifer Johnson, April Armstrong, Nasim Fazel
INTRODUCTION: Patient treatment satisfaction and adherence may be affected by the initial understanding of outcomes in the treatment of actinic keratoses with 5-fluorouracil 5% cream (5-FU). Pre-treatment educational videos may optimize this understanding. The objective of this study was to determine whether prospective patient viewing of an educational video delineating treatment effects and expectations improves patient satisfaction and treatment completion rates for the treatment of actinic keratoses with 5-FU...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27717097/p16-immunostaining-in-keratinocytic-neoplasia-in-organ-transplant-recipients-bowen-s-disease-shows-a-characteristic-pattern
#10
Roel E Genders, Samuel Beck, Jan Nico Bouwes Bavinck, Henk A M van den Munckhof, Stijn T P Kouwenhoven, Maurits N C de Koning, Frank R de Gruijl, David Jenkins, Rein Willemze, Koen D Quint
BACKGROUND: For selecting therapy, it is important to distinguish different types of keratinocytic neoplasia. It is sometimes difficult to make histopathologic diagnosis, especially in organ transplant recipients (OTR) who develop numerous lesions. METHODS: To investigate p16 immunostaining in different types of keratinocytic neoplasia in OTR, we studied 59 actinic keratoses (AK), 51 Bowen' s disease (BD), 63 squamous cell carcinomas (SCC), 16 benign keratotic lesions (BKL) from 31 OTR patients and 25 controls (eczema and psoriasis)...
January 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27715356/the-cost-effectiveness-of-5-fu-sa-in-the-treatment-of-actinic-keratoses-of-the-face-and-scalp-in-the-uk-secondary-care-setting
#11
Radek Wojcik, Julia Lowin, David Vilardell, Silvia Maeso, Leonardo Ruiz, John Lear, Colin Morton
OBJECTIVE: The objective of this analysis was to estimate the relative cost-effectiveness of Actikerall * (5-FU-SA) versus cryotherapy in a secondary care setting in the UK, for lesion-directed treatment in patients with actinic keratoses (AK) of the face and scalp. METHODS: The model was a simple decision tree, with a 6-month time horizon. The perspective was that of the UK National Health Service (NHS). Modelled treatment effects included reported per-patient histological clearance and recurrence rates...
October 7, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27701669/assessing-the-concordance-of-actinic-keratosis-counts-on-digital-photographs-with-clinical-examination-in-organ-transplant-recipients
#12
Zainab Jiyad, Peter O'Rourke, H Peter Soyer, Adèle C Green
Actinic keratoses (AKs) are common lesions that are usually diagnosed clinically. We sought to examine the accuracy of AK counts on digital photographs when compared with clinical examination counts. Skin sites of renal transplant recipients were examined clinically and on digital photographs by independent dermatologically-trained examiners. Specificity, sensitivity and Kendall's tau-b correlation coefficient were calculated based on exact photographic AK counts as well as counts with ± 1 AK tolerance...
October 4, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27689135/topical-colchicine-gel-versus-diclofenac-sodium-gel-for-the-treatment-of-actinic-keratoses-a-randomized-double-blind-study
#13
Gita Faghihi, Azam Elahipoor, Fariba Iraji, Shadi Behfar, Bahareh Abtahi-Naeini
Introduction. Actinic keratoses (AKs), a premalignant skin lesion, are a common lesion in fair skin. Although destructive treatment remains the gold standard for AKs, medical therapies may be preferable due to the comfort and reliability .This study aims to compare the effects of topical 1% colchicine gel and 3% diclofenac sodium gel in AKs. Materials and Methods. In this randomized double-blind study, 70 lesions were selected. Patients were randomized before receiving either 1% colchicine gel or 3% diclofenac sodium cream twice a day for 6 weeks...
2016: Advances in Medicine
https://www.readbyqxmd.com/read/27672408/an-investigator-initiated-study-to-assess-the-safety-and-efficacy-of-ingenol-mebutate-0-05-gel-when-used-after-cryosurgery-in-the-treatment-of-hypertrophic-actinic-keratosis-on-dorsal-hands
#14
Peter W Hashim, John K Nia, Skylar Singer, Gary Goldenberg
OBJECTIVES: To evaluate the safety and efficacy of ingenol mebutate 0.05% gel after cryosurgery versus cryosurgery alone for the treatment of hypertrophic and nonhypertrophic actinic keratosis on the dorsal hands. DESIGN: Investigator-blinded split arm study. SETTING: Academic institution. PARTICIPANTS: Sixteen subjects with actinic keratoses on dorsal hands. RESULTS: There was a mean reduction in the number of hypertrophic actinic keratosis lesions adjusted for baseline in ingenol mebutate-treated versus control group of -4...
July 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/27622260/fingernail-photo-onycholysis-after-aminolevulinic-acid-photodynamic-therapy-under-blue-light-for-treatment-of-actinic-keratoses-on-the-face
#15
Karina Paci, Rebecca Todd Bell, Beth Goldstein
No abstract text is available yet for this article.
August 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/27613022/-actinic-keratoses
#16
REVIEW
T Hommel, R-M Szeimies
Actinic keratosis (AK) is a very common skin diagnosis in office-based dermatology. Due to the demographic changes with increasing numbers of elderly people, the proportion of patients with AK is expected rise. In order to avoid progression into squamous cell carcinoma, early treatment is recommended. Numerous treatment options are currently available for this purpose. In addition to targeted therapies for isolated AK many field-directed treatment modalities are available. However, the treatment option that is finally chosen depends on a variety of factors (e...
November 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27612149/tumor-preferential-induction-of-immune-responses-and-epidermal-cell-death-in-actinic-keratoses-by-ingenol-mebutate
#17
Steffen Emmert, Holger A Haenssle, John R Zibert, Margarete Schön, Andreas Hald, Maria H Hansen, Thomas Litman, Michael P Schön
UNLABELLED: The rapid and strong clinical efficacy of the first-in-class, ingenol mebutate, against actinic keratosis (AK) has resulted in its recent approval. We conducted the first comprehensive analysis of the cellular and molecular mode of action of topical ingenol mebutate 0.05% gel in both AK and uninvolved skin of 26 patients in a phase I, single-center, open-label, within-patient comparison. As early as 1 day after application, ingenol mebutate induced profound epidermal cell death, along with a strong infiltrate of CD4+ and CD8+ T-cells, neutrophils, and macrophages...
2016: PloS One
https://www.readbyqxmd.com/read/27607027/new-developments-in-occupational-dermatology
#18
Thomas L Diepgen
Occupational skin diseases according to BK No. 5101 - "severe or recurrent skin diseases which have forced the person to discontinue all occupational activities that caused or could cause the development, worsening, or recurrence of the disease" - is the most commonly reported notifiable occupational diseases in Germany. Following the optimization of measures of primary, secondary, and tertiary prevention, today most individuals affected are able to continue their profession. With the revision of the German ordinance on occupational diseases (BKV) in January 2015, skin cancer caused by UV irradiation was added to the list of occupational diseases...
September 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27602968/microneedling-prior-to-levulan-pdt-for-the-treatment-of-actinic-keratoses-a-split-face-blinded-trial
#19
James M Spencer, Scott A Freeman
INTRODUCTION: Photodynamic Therapy (PDT) with topical Levulan is an approved and efficacious method for treating actinic keratoses. This therapy depends on the ability of the Levulan (delta amino levulinic acid) to penetrate the stratum corneum and enter the cells of the epidermis. Microneedling is an increasing popular cosmetic therapy in which an array of tiny needles is used to make holes in the epidermis and presumably induce a wound healing cascade that leads to cosmetic improvement of the skin...
September 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/27578305/a-randomized-split-face-clinical-trial-of-photodynamic-therapy-with-methyl-aminolevulinate-versus-ingenol-mebutate-gel-for-the-treatment-of-multiple-actinic-keratoses-of-the-face-and-scalp
#20
Cristina Zane, Antonella Fabiano, Mariachiara Arisi, Piergiacomo Calzavara-Pinton
BACKGROUND: Photodynamic therapy with methyl aminolevulinate (MAL-PDT) and ingenol mebutate gel (IMB) are approved therapeutic options for multiple actinic keratoses (AKs). OBJECTIVE: The aim of this intraindividual, split-face, randomized clinical trial was to compare treatment outcomes of MAL-PDT and IMB. METHODS: Two symmetrical contralateral areas with a similar number of AKs were selected and randomly assigned to 3 days of an IMB treatment cycle or a single session of MAL-PDT...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
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