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Actinic keratoses

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https://www.readbyqxmd.com/read/29136306/patient-and-physician-satisfaction-in-an-observational-study-with-methyl-aminolevulinate-daylight-photodynamic-therapy-in-the-treatment-of-multiple-actinic-keratoses-of-the-face-and-scalp-in-6-european-countries
#1
M C Fargnoli, S H Ibbotson, R E Hunger, G Rostain, M T W Gaastra, L Eibenschutz, C Cantisani, A W Venema, S Medina, N Kerrouche, B Pérez-Garcia
BACKGROUND: Guidelines recommend treating actinic keratoses (AK) as they are recognized as precursors of invasive squamous cell carcinoma. OBJECTIVE: The objective of this study was to collect real-world clinical data on the use of methyl aminolevulinate daylight-photodynamic therapy (MAL DL-PDT) for the treatment of face and scalp AK in Europe. METHODS: A prospective, multicenter, non-interventional study was conducted in 6 European countries in patients receiving a single treatment of MAL DL-PDT for face and/or scalp AK...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29117441/actinic-keratosis-area-and-severity-index-akasi-is-associated-with-the-incidence-of-squamous-cell-carcinoma
#2
L Schmitz, T Gambichler, G Gupta, M Stücker, T Dirschka
BACKGROUND: Actinic keratoses (AKs) are commonly diagnosed clinically. Actinic keratosis area and severity index (AKASI) is a new easy-to-use tool to assess the severity of AK on the head. OBJECTIVE: To determine the association between chronically UV-induced tumours such as basal cell carcinomas (BCC) or squamous cell carcinomas (SCC) and AKASI. METHODS: We performed a retrospective analysis of patients who had undergone oncological surgery due to UV-induced tumours and who were assessed for AKASI and Physician's Global Assessment (PGA) prior to surgery...
November 8, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29115209/exploring-the-use-of-ingenol-mebutate-to-prevent-non-melanoma-skin-cancer
#3
Andrés Már Erlendsson
Non-melanoma skin cancer is the most frequently occurring cancer in Caucasians today. Incidence rates in Europe have increased steadily since the 1960s and more than tripled over the last 50 years. Despite primary preventative efforts, incidences of non-melanoma skin cancer continue to rise and development of effective chemopreventative strategies is needed. In 2013, ingenol mebutate was approved in Denmark as a new topical drug for field-directed treatment for actinic keratoses. Ingenol mebutate has a dual mechanism of action, causing initial cell death, followed by an immune activation...
November 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/29070025/daylight-photodynamic-therapy-versus-cryosurgery-for-the-treatment-and-prophylaxis-of-actinic-keratoses-of-the-face%C3%A2-%C3%A2-protocol-of-a-multicenter-prospective-randomized-controlled-two-armed-study
#4
E Kohl, M Koller, F Zeman, R-M Szeimies, W G Philipp-Dormston, W Prager, P A Gerber, S Karrer
BACKGROUND: Photodynamic therapy with daylight (DL-PDT) is efficacious in treating actinic keratosis (AK), but the efficacy of field-directed, repetitive DL-PDT for the treatment and prophylaxis of AK in photodamaged facial skin has not yet been investigated. METHODS/DESIGN: In this multicenter, prospective, randomized, controlled, two-armed, observer-blinded trial, patients with a minimum of 5 mild-to-moderate AK lesions on photodamaged facial skin are randomly allocated to two treatment groups: DL-PDT with methyl aminolevulinate (MAL) and cryosurgery...
October 25, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/29053537/thermal-ultra-short-photodynamic-therapy-heating-fibroblasts-during-sub-30-minute-incubation-of-5-aminolevulinic-acid-increases-photodynamic-therapy-induced-cell-death
#5
Eugene Koo, Evan Austin, Andrew Mamalis, Jared Jagdeo
BACKGROUND: Actinic keratoses (AKs) prevalence was estimated at 39.5 million Americans in 2004, and the cost to treat AKs that year was approximately 1 billion dollars. Photodynamic therapy (PDT) is an FDA-approved therapy for the treatment of AK. Recent studies have focused on reducing PDT treatment time while maintaining efficacy. OBJECTIVE: To investigate the use of thermal modulation to improve the efficacy of ultra short aminolevulinic acid (ALA) incubation PDT...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29036257/improvement-of-actinic-keratoses-using-topical-dna-repair-enzymes-a-randomized-placebo-controlled-trial
#6
Marie Stoddard, Jennifer Herrmann, Lauren Moy, Ronald Moy
BACKGROUND: Actinic keratoses (AKs) are proliferations of abnormal keratinocytes, which may progress into non-melanoma skin cancers. Although multiple treatment modalities exist for AKs, their incidence continues to rise, making new methods of both prevention and treatment necessary. DNA repair enzymes have been shown to reverse sun-damage, resulting in reduced rates of AKs and non-melanoma skin cancer (NMSC) in specific patient populations. OBJECTIVE: We investigated the efficacy of a topical DNA repair enzyme lotion as a field therapy for AKs...
October 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29029915/frequent-skin-examinations-in-patients-with-actinic-keratoses-ethical-financial-and-moral-implications
#7
Philip Milam, Abraham Korman, Jessica Kaffenberger
No abstract text is available yet for this article.
November 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29018888/-non-melanoma-skin-cancer-pathogenesis-prevalence-and-prevention
#8
A Zink
Non-melanoma skin cancer (NMSC) is the most common malignancy of the light-skinned population with an enormous socioeconomic impact. Historically known as incurable under the term noli me tangere (transl. do not touch me), today various non-melanocytic cutaneous neoplasms are grouped as NMSC. The most common of these, basal cell carcinoma, squamous cell carcinoma and actinic keratoses as carcinomas in situ, are increasingly called keratinocyte carcinoma. Today, the pathogenesis and risk factors of NMSC are relatively well understood, which has led to multiple treatment options, the recognition of NMSC as an occupational disease in Germany and a variety of prevention approaches...
November 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28979661/a-prospective-pilot-clinical-trial-to-evaluate-the-efficacy-and-safety-of-topical-therapy-with-ingenol-mebutate-gel-0-015-for-actinic-keratosis-on-an-expanded-area-of-the-chest
#9
Douglas C Wu, Isabella Guiha, Mitchel P Goldman
BACKGROUND: Ingenol mebutate gel 0.05% once daily for two consecutive days provides high clearance rates for actinic keratosis on a 25cm(2) area of the chest. However, it may cause intense local skin responses. OBJECTIVE: The objective of this study was to determine whether a lower dose of ingenol mebutate gel 0.015% could clear actinic keratosis on the chest with acceptable tolerability and a possible beneficial effect on photodamage and cosmesis. DESIGN: This was a noncomparative, open-label study (NCT02446223)...
August 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28975210/the-treatment-of-actinic-keratoses-the-rule-rather-than-the-exception-reply
#10
Joslyn S Kirby
No abstract text is available yet for this article.
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28975200/the-treatment-of-actinic-keratoses-the-rule-rather-than-the-exception
#11
Bobbak Mansouri, Chad D Housewright
No abstract text is available yet for this article.
November 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28972663/conventional-vs-daylight-photodynamic-therapy-for-patients-with-actinic-keratosis-on-face-and-scalp-12-month-follow-up-results-of-a-randomized-intraindividual-comparative-analysis
#12
Elena Sotiriou, George Evagelou, Evangelia Papadavid, Zoe Apalla, Fotini Vrani, Efstratios Vakirlis, Maro Panagiotou, Maria Stefanidou, Tsampikos Pombou, Konstantinos Krasagakis, Dimitrios Rigopoulos, Demetrios Ioannides
INTRODUCTION: Daylight PDT (DLPDT) is a new PDT procedure. Several trials demonstrate that DLPDT achieves similar response rates with conventional PDT (CPDT) in the treatment of nonhyperkeratotic actinic keratoses (AKs) in a nearly painless way. It seems that DLPDT represents a more convenient and equally effective treatment modality. Data on long-term efficacy of DLPDT are limited. OBJECTIVE: To compare short- and long-term efficacy, safety and tolerability of DLPDT with that of CPDT in face and scalp AKs...
October 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28905294/high-patient-satisfaction-with-daylight-activated-methyl-aminolevulinate-cream-in-the-treatment-of-multiple-actinic-keratoses-results-of-an-observational-study-in-australia
#13
Jo-Ann See, Kurt Gebauer, Jason K Wu, Shobhan Manoharan, Nabil Kerrouche, John Sullivan
INTRODUCTION: Actinic keratoses (AK) are treated to reduce the risk of progression to squamous cell carcinoma and for symptomatic and cosmetic benefits. The objective of this observational study was to generate real-life data on the use of daylight photodynamic therapy with methyl aminolevulinate cream (MAL DL-PDT) in treating mild to moderate facial/scalp AK. METHODS: A multicenter, prospective, observational study was conducted in Australia in patients receiving a single treatment of MAL DL-PDT for mild to moderate AK...
September 13, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28871935/topical-imiquimod-is-an-effective-and-safe-drug-for-molluscum-contagiosum-in-children
#14
George Badavanis, Efstathia Pasmatzi, Alexandra Monastirli, Sophia Georgiou, Dionysios Tsambaos
Dear Editor, Molluscum contagiosum (MC) is a very common skin infection caused by a molluscipox virus gene of the poxvirus family. It usually occurs in young children, sexually active adults, and immunocompromised individuals. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or multiple papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes. In adults, the skin lesions are predominantly located in the genital region, whereas in children they are found on the trunk, the extremities, and the face...
July 2017: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28853496/incidence-and-regression-of-actinic-keratoses-in-organ-transplant-recipients
#15
Zainab Jiyad, Louise Marquart, Peter O'Rourke, Adèle C Green
Actinic keratoses (AKs) are highly dynamic lesions and AK activity has been shown to be associated with squamous cell carcinoma (SCC). We sought to explore risk factors which may affect the 12-month turnover of AKs in organ transplant recipients (OTRs). The number of incident AKs, regressed AKs and net change in AK counts were calculated. Negative binomial regression and Poisson regression models were used to estimate rate ratios (RR) for these 3 outcomes. Among 150 renal and 89 liver OTRs, those who spent > 50% of a typical weekday in the sun had a lower rate of AK regression than those who spent minimal time in the sun during a typical weekday...
August 30, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28844940/subclonal-evolution-of-cancer-related-gene-mutations-in-p53-immunopositive-patches-in-human-skin
#16
Amel A Albibas, Matthew J J Rose-Zerilli, Chester Lai, Reuben J Pengelly, Gabrielle A Lockett, Jeffrey Theaker, Sarah Ennis, John W Holloway, Eugene Healy
Normal sun-exposed skin contains numerous epidermal patches that stain positive for p53 protein (p53 immunopositive patches; PIPs), which are considered potential early precursors of skin cancer. Whilst the TP53 gene is mutated in many PIPs, it is unclear whether PIPs contain any other cancer-related mutations. Here we report that PIPs, predominantly <3,000 p53 immunopositive cells in size, within normal chronically exposed skin contain mutations in multiple genes which are mutated in cutaneous squamous cell cancers...
August 24, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28809998/temporal-association-of-herpes-zoster-eruption-post-aminolevulinic-acid-hydrochloride-photodynamic-therapy-for-actinic-keratoses
#17
Katie Manno, Joel L Cohen
<p>Herpes zoster is a common and painful disease caused by the reactivation of the varicella-zoster virus with a higher incidence and severity associated with increasing age as well as compromised immune status. Acute inciting events for this eruption are not always known, but can include illness, stress, and mechanical injury. Photodynamic therapy (PDT) is a widely used treatment modality for precancerous skin lesions that has not been previously associated with provoking a herpes zoster outbreak. We present a case of herpes zoster eruption occurring after PDT for actinic keratoses in a patient with Non-Hodgkin Lymphoma (NHL)...
August 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28796914/actinic-keratoses-show-variable-histological-basal-growth-patterns-a-proposed-classification-adjustment
#18
L Schmitz, T Gambichler, G Gupta, M Stücker, E Stockfleth, R M Szeimies, T Dirschka
BACKGROUND: Common histological classification schemes of actinic keratoses (AK) do not evaluate growth patterns at basal epidermal aspects of AK. Until now, the importance of basal epidermal growth patterns of AK has not been studied. OBJECTIVE: To investigate the extent of atypical keratinocytes throughout the epidermis and variation in basal growth patterns of AK. METHODS: AK lesions occurring on the head/face from patients seen in routine practice were assessed histologically...
August 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28796885/photodynamic-therapy-is-more-effective-than-imiquimod-for-actinic-keratosis-in-organ-transplant-recipients-a-randomized-intra-individual-controlled-trial
#19
K Togsverd-Bo, C Halldin, C Sandberg, H Gonzalez, A M Wennberg, S S Sørensen, H C O Wulf, M Haedersdal
BACKGROUND: Actinic keratoses (AKs) in solid organ transplant recipients (OTRs) are difficult-to-treat pre-malignancies and comparison of topical therapies is therefore warranted. OBJECTIVES: In an intra-individual study to compare efficacy and safety of field treatment with methyl aminolevulinate photodynamic therapy (MAL-PDT) and imiquimod (IMIQ) for AKs in OTRs. MATERIALS AND METHODS: OTRs (n=35) with 572 AKs (grade I-III) in two similar areas in the face, scalp, dorsal hands or forearms were included...
August 10, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28780136/pain-during-topical-photodynamic-therapy-comparing-methyl-aminolevulinate-metvix-%C3%A2-to-aminolaevulinic-acid-ameluz-%C3%A2-an-intra-individual-clinical-study
#20
Shiva Yazdanyar, Kian Zarchi, Gregor B E Jemec
BACKGROUND: Actinic keratoses are often treated by photodynamic therapy. However, the main side effects of this treatment is pain during and short after illumination. OBJECTIVES: To evaluate, in an intra-individual study, whether the pain response differ in treatment of actinic keratoses in scalp and forhead, using branded methyl aminolevulinate (MAL) and aminolaevulinic acid (ALA). Materials and methods Patients with mild to moderate actinic keratoses on forehead and scalp were treated with methyl aminolaevulinate (MAL)-PDT and aminolaevulinic acid (ALA)-PDT on two similar areas of forehead and scalp...
August 2, 2017: Photodiagnosis and Photodynamic Therapy
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