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Actinic keratoses

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https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#1
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28708084/molecular-mechanisms-of-human-papillomavirus-induced-skin-carcinogenesis
#2
Martin Hufbauer, Baki Akgül
Infection of the cutaneous skin with human papillomaviruses (HPV) of genus betapapillomavirus (βHPV) is associated with the development of premalignant actinic keratoses and squamous cell carcinoma. Due to the higher viral loads of βHPVs in actinic keratoses than in cancerous lesions, it is currently discussed that these viruses play a carcinogenic role in cancer initiation. In vitro assays performed to characterize the cell transforming activities of high-risk HPV types of genus alphapapillomavirus have markedly contributed to the present knowledge on their oncogenic functions...
July 14, 2017: Viruses
https://www.readbyqxmd.com/read/28695987/actinic-keratoses-treated-with-cold-atmospheric-plasma
#3
M Wirtz, I Stoffels, J Dissemond, D Schadendorf, A Roesch
Plasma is a partially or fully ionized gaseous state of matter containing chemically active species, such as ions, electrons, photons, reactive oxygen and nitrogen species, and UV light. Cold atmospheric plasma (CAP) can be applied onto vital, heat-sensitive surfaces and is currently used in surgery, endoscopic procedures, and wound care with proven antimicrobial efficacy and the ability to deactivate pathogens, stop bleeding and stimulate cell proliferation (1)(2) . Recent pre-clinical observations suggested an anti-tumoral potential, for example in melanoma, glioma and colorectal carcinoma cells (3)(4) ...
July 11, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28692931/automatic-discrimination-of-actinic-keratoses-from-clinical-photographs
#4
Panagiota Spyridonos, Georgios Gaitanis, Aristidis Likas, Ioannis D Bassukas
BACKGROUND AND OBJECTIVE: Actinic keratoses (AK) are common premalignant skin lesions that can progress to invasive skin squamous cell carcinoma (sSCC). The subtle accumulation of multiple AK in aging individuals increases the risk of sSCC development, and this underscores the need for efficient treatment and patient follow-up. Our objectives were to develop a method based on color texture analysis of standard clinical photographs for the discrimination of AK from healthy skin and subsequently to test the developed approach in the quantification of field-directed treatment interventions...
July 3, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28685901/erosive-pustular-dermatosis-of-the-scalp-following-topical-ingenol-mebutate-for-actinic-keratoses
#5
Mario Vaccaro, Francesco Borgia, Lorenzo Gasco, Serafinella P Cannavò
No abstract text is available yet for this article.
July 7, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/28681504/melanoma-and-non-melanoma-skin-cancer-chemoprevention-a-role-for-nicotinamide
#6
REVIEW
Rashi Minocha, Diona L Damian, Gary M Halliday
Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis. Nicotinamide (Vitamin B3 ) enhances DNA repair, modulates the inflammatory environment produced by UVR and reduces UV-induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and non-melanoma skin cancers in high-risk individuals, and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations...
July 5, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28662116/actinic-keratosis-modelling-in-mice-a-translational-study
#7
Arnaud Pillon, Bruno Gomes, Isabelle Vandenberghe, Valérie Cartron, Patrick Cèbe, Jean-Christophe Blanchet, Vincent Sibaud, Nicolas Guilbaud, Laurent Audoly, Laurence Lamant, Anna Kruczynski
BACKGROUND: Actinic keratoses (AK) are pre-malignant cutaneous lesions caused by prolonged exposure to ultraviolet radiation. As AKs lesions are generally accepted to be the initial lesions in a disease continuum that progresses to squamous cell carcinoma (SCC), AK lesions have to be treated. They are also the second most common reason for visits to the dermatologist. Several treatments are available but their efficacy still needs to be improved. The UV-B-induced KA lesion mouse model is used in preclinical studies to assess the efficacy of novel molecules, even though it is often more representative of advanced AK or SCC...
2017: PloS One
https://www.readbyqxmd.com/read/28661544/efficacy-of-a-daily-protective-moisturizer-with-high-uvb-and-uva-photoprotection-in-decreasing-ultraviolet-damage-evaluation-by-reflectance-confocal-microscopy
#8
Antonio Gomes-Neto, Paula Aguilera, Leonor Prieto, Sophie Seité, Dominique Moyal, Cristina Carrera, Josep Malvehy, Susana Puig
Patients with photodermatoses or actinic keratoses benefit from very high ultraviolet B-ultraviolet A (UVB-UVA) photoprotection. However, poor compliance is an issue that jeopardizes adequate protection, leading to disease recurrence. This study evaluated the efficacy of a daily protective moisturizer with high UVB and UVA photoprotection applied 8 h before irradiation. A monocentric, open-label, prospective, control pilot study was performed including 10 patients. Patients were irradiated with UVB and UVA before and 8 h after topical application of the product...
June 29, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28647616/photodynamic-therapy-in-dermatology-beyond-non-melanoma-cancer-an-update
#9
REVIEW
Xiang Wen, Yong Li, Michael R Hamblin
Photodynamic therapy (PDT) employs a photosensitizer (PS) and visible light in the presence of oxygen, leading to production of cytotoxic reactive oxygen species, which can damage the cellular organelles and cause cell death. In dermatology PDT has usually taken the form of topical application of a precursor in the heme biosynthesis pathway, called 5-aminolevulinic acid (or its methyl ester), so that an active PS, protoporphyrin IX accumulates in the skin. As PDT enhances dermal remodeling and resolves chronic inflamation, it has been used to treat cutaneous disorders include actinic keratoses, acne, viral warts, skin rejuvenation, psoriasis, localized scleroderma, some non-melanoma skin cancers and port-wine stains...
June 21, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28595997/hpv8-field-cancerization-in-a-transgenic-mouse-model-is-due-to-lrig1-keratinocyte-stem-cell-expansion
#10
Simone Lanfredini, Carlotta Olivero, Cinzia Borgogna, Federica Calati, Kathryn Powell, Kelli-Jo Davies, Marco De Andrea, Sarah Harries, Hiu Kwan Carolyn Tang, Herbert Pfister, Marisa Gariglio, Girish K Patel
β-HPV cause near ubiquitous latent skin infection within long-lived hair follicle keratinocyte stem cells (HF KSC). In patients with epidermodysplasia verruciformis (EV), β-HPV viral replication is associated with skin keratosis and cutaneous squamous cell carcinoma (SCC). To determine the role of HF KSC in β-HPV induced skin carcinogenesis, we utilized a transgenic mouse model in which the keratin 14 promoter drives expression of the entire HPV8 early region (HPV8tg). HPV8tg mice developed thicker skin in comparison to wild type littermates consistent with a hyperproliferative epidermis...
June 5, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28593242/primary-care-based-skin-cancer-screening-in-a-veterans-affairs-health-care-system
#11
Susan M Swetter, Julia Chang, Amanda R Shaub, Martin A Weinstock, Eleanor T Lewis, Steven M Asch
Importance: Skin cancer screening may improve melanoma outcomes and keratinocyte carcinoma morbidity, but little is known about the feasibility of skin cancer training and clinical skin examination (CSE) by primary care practitioners (PCPs) in large health care systems. Objective: To assess the association of skin cancer training and screening by PCPs with dermatology referral patterns and rates of skin biopsies. Design, Setting, and Participants: In this pilot interventional study performed at the Veterans Affairs Palo Alto Health Care System, patients 35 years or older scheduled for an annual health habits screen in the PCP general medicine clinics were studied...
June 7, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28591439/retrospective-evaluation-of-exposure-to-natural-uv-radiation-experiences-with-the-online-uv-history-tool-in-a-field-study
#12
Wobbeke Weistenhöfer, Julia Hiller, Hans Drexler, Johannes Kiesel
BACKGROUND: Cutaneous squamous cell carcinoma and multiple actinic keratoses can be recognized as occupational diseases if the site affected has been subjected to additional occupational UV exposure of at least 40 %. An online UV history tool that allows for the quantification of occupational and recreational UV doses was now tested in a field study. PATIENTS AND METHODS: Ninety-nine patients with nonmelanoma skin cancer were examined. Patient history with respect to UV exposure was obtained using the online UV history tool...
June 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28580871/pharmacoeconomic-evaluations-in-the-treatment-of-actinic-keratoses
#13
Keith Tolley, Giuseppe Argenziano, Pier Giacomo Calzavara-Pinton, Thomas Larsson, Lasse Ryttig
Actinic keratoses (AKs) develop as a consequence of chronic ultraviolet (UV) exposure and exist on a continuum with squamous cell carcinoma (SCC). As one of the most common conditions treated by dermatologists, AK places a significant burden on patients and the healthcare system. A range of treatments are used, including topical treatments that target the visible and subclinical lesions. The goal of such therapies is to achieve complete clearance of AKs and eliminate the risk of progression to SCC. Robust meta-analyses of trial data can provide valuable information for the optimal management of AK and cost-effectiveness evaluations of topical treatments, such as ingenol mebutate gel and diclofenac...
June 2017: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/28579816/tattoo-removal-with-ingenol-mebutate
#14
Sarah-Jane Cozzi, Thuy T Le, Steven M Ogbourne, Cini James, Andreas Suhrbier
An increasing number of people are getting tattoos; however, many regret the decision and seek their removal. Lasers are currently the most commonly used method for tattoo removal; however, treatment can be lengthy, costly, and sometimes ineffective, especially for certain colors. Ingenol mebutate is a licensed topical treatment for actinic keratoses. Here, we demonstrate that two applications of 0.1% ingenol mebutate can efficiently and consistently remove 2-week-old tattoos from SKH/hr hairless mice. Treatment was associated with relocation of tattoo microspheres from the dermis into the posttreatment eschar...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28566904/arborizing-vessels-on-dermoscopy-in-various-skin-diseases-other-than-basal-cell-carcinoma
#15
Hyunju Jin, Min-Young Yang, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Byung-Soo Kim, Moon-Bum Kim
BACKGROUND: Arborizing vessels (AVs) are dermoscopically defined as telangiectasias with distinct treelike branching, and are a characteristic feature of basal cell carcinoma (BCC). However, AVs are observed in various conditions other than BCC. OBJECTIVE: The aim of this study was to investigate skin diseases showing AV and investigates dermoscopic differences between BCC and non-BCC. METHODS: Dermoscopic images showing AV were prospectively collected and classified into BCC/non-BCC...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28562434/treatment-of-actinic-keratoses-a-randomized-split-site-approach-comparison-of-sequential-5-fluorouracil-and-5-aminolevulinic-acid-photodynamic-therapy-to-5-aminolevulinic-acid-photodynamic-monotherapy
#16
Susan Pei, Edidiong C N Kaminska, Maria M Tsoukas
BACKGROUND: Actinic keratoses (AKs) are skin lesions resulting from sun exposure and carry a risk of developing into squamous cell carcinoma. Current therapies for AK eradication include topical 5-fluorouracil (5-FU) and photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA). However, sequential therapy with 5-FU-ALA-PDT may offer improved outcome compared to ALA-PDT alone. OBJECTIVE: The purpose of this study is to compare the long-term efficacy of AK clearance by sequential therapy with 5-FU-ALA-PDT versus ALA-PDT alone...
May 25, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28538027/dermatoscopic-patterns-of-nonfacial-actinic-keratosis-characterization-of-pigmented-and-nonpigmented-lesions
#17
Clarissa P H Reinehr, Gabriela C Garbin, Renato M Bakos
BACKGROUND: Actinic keratoses (AKs) are dysplastic proliferations of keratinocytes. Studies evaluating nonfacial dermatoscopic pattern of AKs are scarce. OBJECTIVE: This study aimed to evaluate the dermatoscopic patterns of AKs located in nonfacial sites and to compare their patterns with facial lesions. MATERIALS AND METHODS: Patients with concomitant facial and nonfacial AKs were recruited to participate and evaluated by clinical and dermatoscopic images of their AKs...
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28524709/pharmacokinetics-of-ingenol-mebutate-gel-under-maximum-use-conditions-in-large-treatment-areas
#18
Alicia D Bucko, Michael Jarratt, Dowling B Stough, Laerke Kyhl, John Villumsen, Anders Hall
PURPOSE: Actinic keratoses (AKs) exist on a continuum with squamous cell carcinoma and can occur as sub-clinical and clinically visible lesions in cancerized fields on sun-damaged skin. Ingenol mebutate effectively treats AKs on areas up to 25 cm(2), but actinic keratosis can affect larger areas of skin. This trial evaluated systemic exposure and safety of ingenol mebutate gel on larger areas of skin under maximum use conditions. METHODS: Phase I, multicenter, open-label, uncontrolled, non-randomized trial...
May 25, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28514458/effect-of-expedited-microneedle-assisted-photodynamic-therapy-for-field-treatment-of-actinic-keratoses-a-randomized-clinical-trial
#19
Tatyana A Petukhova, Lauren A Hassoun, Negar Foolad, Mayanka Barath, Raja K Sivamani
Importance: Photodynamic therapy (PDT) is an effective and cosmetically favorable treatment modality for actinic keratoses (AKs). However, prolonged incubation times and pain associated with treatment are burdensome to the patient and a hindrance to widespread use of PDT as standard field therapy for AK. Objective: To evaluate efficacy and pain associated with microneedle expedited PDT. Design, Setting, and Participants: The Microneedle Photodynamic Therapy II (MNPDT-II) study was a randomized, single-blinded, split-face controlled, 2-arm clinical trial...
July 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28511619/daylight-photodynamic-therapy-in-scotland
#20
Helen Cordey, Ronan Valentine, Andrea Lesar, Harry Moseley, Ewan Eadie, Sally Ibbotson
Chronic sun-induced dysplastic skin changes (actinic keratoses) are extremely common in fair-skinned people in Scotland. These changes are a major cause of morbidity and may develop into skin cancer. Actinic keratoses are often extensive and pose a therapeutic challenge as field-directed treatment is required for chronic disease management. One such treatment approach is hospital-based photodynamic therapy, which is a well-established treatment in Scotland for actinic keratoses, using a photosensitiser pro-drug and red LED light irradiation...
January 1, 2017: Scottish Medical Journal
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