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Actinic keratoses

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https://www.readbyqxmd.com/read/28225978/daylight-photodynamic-therapy-experience-and-safety-in-treatment-of-actinic-keratoses-of-the-face-and-scalp-in-low-latitude-and-high-brightness-region
#1
Luiz Eduardo Garcia Galvão, Heitor de Sá Gonçalves, Karine Paschoal Botelho, Juliana Chagas Caldas
Daylight photodynamic therapy has been used in countries with high latitudes during the summer for actinic keratoses treatment with reports of similar efficacy to conventional photodynamic therapy. We evaluate its safety in 20 patients in the city of Fortaleza, a local with low latitude and high brightness. Sixteen patients did not report any discomfort due to the procedure. Daylight photodynamic therapy is an easy application method with great tolerability by the patient and has the possibility of being performed throughout the year in these regions...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28224020/ingenol-mebutate-topical-gel-a-status-report-on-clinical-use-beyond-actinic-keratosis
#2
James Q Del Rosso
Ingenol mebutate is available as a topical gel formulation approved for the treatment of actinic keratosis. Two different concentrations are available for treatment of actinic keratoses at specific anatomic sites with the advantages of short durations of therapy and limited "down time" related to visible inflammation as compared to other topical agents. Due to the various modes of action of ingenol mebutate, it has also been used for treatment of disease states other than actinic keratosis. This manuscript discusses the suggested modes of action of ingenol mebutate and reviews publications on the use of ingenol mebutate gel for cutaneous disorders other than actinic keratosis, including squamous cell carcinoma in-situ, basal cell carcinoma, actinic cheilitis, anogenital warts, and others...
November 2016: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/28221211/a-rare-case-of-ck20-ck7-double-negative-merkel-cell-carcinoma
#3
Mary D Le, Luke H OʼSteen, David S Cassarino
The authors present a case of Merkel cell carcinoma (MCC) with unique immunohistochemical staining characteristics. A 57-year-old woman presented with a firm 0.3 cm tan papule on her left nasal-labial fold that was reportedly increasing in size and bleeding. She had a history of multiple head and neck actinic keratoses, papillary thyroid carcinoma, and a family history of an uncle with melanoma. The clinical differential diagnosis was "non-melanoma skin cancer." Histological examination showed a markedly atypical-appearing basaloid neoplasm, present mostly in the dermis, with focal pagetoid spread into the epidermis...
March 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28211039/cutaneous-squamous-cell-carcinoma-an-epidemiological-review
#4
REVIEW
A C Green, C M Olsen
Cutaneous squamous cell carcinoma (SCC) is a common cancer in white populations and its disease burden is often substantially underestimated. SCC occurs more often in men than women and increases dramatically with age; those affected often develop multiple primaries over time, which increases the burden. The main external cause is solar ultraviolet radiation (UVR), with immunosuppression being the other established risk factor, shown by the high SCC rates in organ transplant recipients. Sunbed use and certain genetic disorders and medical conditions are also associated with SCC, while associations with human papillomavirus infection and high bodyweight are not established...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28107575/spanish-version-of-actinic-keratosis-quality-of-life-questionnaire-akqol
#5
I Alarcon, G R Vinding, K B Christensen, S Esmann, J Malvehy, S Puig, G B E Jemec
BACKGROUND: Patient Reported Outcome Measures are very important outcomes. For specific diseases Health Related Quality of Life-instruments (HRQoL) are increasingly used to provide data on patients' overall perceptions of the course of a given disease. Actinic keratoses (AKs) are common keratotic lesions that occur on chronically sunlight-exposed skin. Only few studies regarding HRQoL in AKs have been made. OBJECTIVE: In order to be able to compare HRQoL among different countries and cultures we aimed to translate and validate the Actinic Keratosis Quality of Life (AKQoL) questionnaire into Spanish and quantify the impairment caused by AKs in Spanish patients...
January 20, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28098368/the-correlation-between-clinical-and-histological-clearance-of-actinic-keratoses
#6
J K Rivers
No abstract text is available yet for this article.
January 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#7
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28095373/comparison-of-lesion-by-lesion-and-field-photodynamic-therapy-in-the-prevention-of-actinic-keratoses-a-randomized-split-face-single-blind-pilot-study
#8
Inge Seubring, Joannes M M Groenewoud, Marie-Jeanne P Gerritsen
BACKGROUND: Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions. Treatment should therefore target an area of field change which may reduce the risk of development of further AKs, second tumours, and local recurrence. OBJECTIVE: The primary objective was to determine the number of new lesions at 9 months after methyl aminolevulinate photodynamic therapy (MAL-PDT)...
January 18, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28093603/monitoring-ingenol-mebutate-gel-treatment-of-actinic-keratoses-by-reflectance-confocal-microscopy
#9
Jose Luis López Estebaranz, Ana Pampín Franco, Reyes Gamo Villegas, Uxúa Floristán
is missing (Short communication).
January 17, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28088998/successful-treatment-of-actinic-keratoses-using-nonthermal-atmospheric-pressure-plasma-a-case-series
#10
Peter C Friedman, Vandana Miller, Gregory Fridman, Abraham Lin, Alexander Fridman
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28063524/switching-from-conventional-photodynamic-therapy-to-daylight-photodynamic-therapy-for-actinic-keratoses-systematic-review-and-meta-analysis
#11
A Tomás-Velázquez, P Redondo
Actinic keratosis is a precursor lesion to the most common nonmelanoma skin cancer. Conventional photodynamic therapy (PDT) has been shown to be effective, but the procedure is time-consuming, can be very painful, and requires infrastructure. These shortcomings led to the emergence of daylight PDT. To obtain a global estimate of efficacy, we undertook a systematic literature review and performed a meta-analysis of the available evidence on the efficacy and safety of daylight PDT as compared to conventional PDT in the treatment of actinic keratosis and/or field cancerization...
January 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28038885/ultraviolet-radiation-and-the-skin-photobiology-and-sunscreen-photoprotection
#12
Antony R Young, Joël Claveau, Ana Beatris Rossi
The efficacy of sunscreens can be measured by different methods, involving in vitro, ex vivo, or in vivo techniques. There is a need for a worldwide standardization of these methods to avoid misunderstanding and confusion among sunscreen users. The clinical benefits of sunscreens have been demonstrated in randomized controlled trials that established the role of sunscreens in the prevention of actinic keratoses, squamous cell carcinomas, nevi, and melanomas. Sunscreens also prevent photoimmunosuppression and signs of photoaging...
December 23, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27992079/expression-of-claudin-11-by-tumor-cells-in-cutaneous-squamous-cell-carcinoma-is-dependent-on-the-activity-of-p38%C3%AE
#13
Liisa Nissinen, Elina Siljamäki, Pilvi Riihilä, Minna Piipponen, Mehdi Farshchian, Atte Kivisaari, Markku Kallajoki, Laura Raiko, Juha Peltonen, Sirkku Peltonen, Veli-Matti Kähäri
The incidence of cutaneous squamous cell carcinoma (cSCC) is rapidly increasing and the prognosis of patients with metastatic disease is poor. There is an emerging need to identify molecular markers for predicting aggressive behavior of cSCC. Here, we have examined the role of tight junction components in the progression of cSCC. The expression pattern of mRNAs for tight junction components was determined with RNA sequencing and oligonucleotide array-based expression analysis from cSCC cell lines (n=8) and normal human epidermal keratinocytes (NHEK, n=5)...
December 19, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27986142/the-natural-history-of-actinic-keratoses-in-organ-transplant-recipients
#14
Zainab Jiyad, Louise Marquart, Peter O'Rourke, Adele C Green
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27906150/ameluz-for-actinic-keratoses
#15
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
December 5, 2016: Medical Letter on Drugs and Therapeutics
https://www.readbyqxmd.com/read/27869649/randomized-trial-of-calcipotriol-combined-with-5-fluorouracil-for-skin-cancer-precursor-immunotherapy
#16
Trevor J Cunningham, Mary Tabacchi, Jean-Pierre Eliane, Sara Moradi Tuchayi, Sindhu Manivasagam, Hengameh Mirzaalian, Ahu Turkoz, Raphael Kopan, Andras Schaffer, Arturo P Saavedra, Michael Wallendorf, Lynn A Cornelius, Shadmehr Demehri
BACKGROUND: Actinic keratosis is a precursor to cutaneous squamous cell carcinoma. Long treatment durations and severe side effects have limited the efficacy of current actinic keratosis treatments. Thymic stromal lymphopoietin (TSLP) is an epithelium-derived cytokine that induces a robust antitumor immunity in barrier-defective skin. Here, we investigated the efficacy of calcipotriol, a topical TSLP inducer, in combination with 5-fluorouracil (5-FU) as an immunotherapy for actinic keratosis...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27832425/histopathologic-pitfalls-of-mohs-micrographic-surgery-and-a%C3%A2-review-of-tumor-histology
#17
REVIEW
Katlein França, Yasser Alqubaisy, Ashraf Hassanein, Keyvan Nouri, Torello Lotti
Mohs micrographic surgery is a specialized subset of staged surgical excisions with each subsequent stage being driven largely by the histologic findings of the previous stage. Therefore, it is imperative that histologic analysis is performed in an accurate manner. Frozen section and tissue flattening is a crucial step in Mohs surgery. Frozen sections introduce certain artifacts and these artifacts must be interpreted in the correct context. Basal and squamous cell carcinomas are the most common tumors encountered in Mohs micrographic surgery, and their histopathology is also associated with certain "pitfalls"...
November 10, 2016: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27788605/a-consensus-on-the-use-of-daylight-photodynamic-therapy-in-the-uk
#18
Sally Ibbotson, Robin Stones, Jonathan Bowling, Sandra Campbell, Stephen Kownacki, Muthu Sivaramakrishnan, Ronan Valentine, Colin A Morton
BACKGROUND: Actinic keratoses (AKs) are a consequence of chronic exposure to ultraviolet radiation. Treatment of chronically photo-damaged skin and AKs is driven by risk of progression to squamous cell carcinoma, as well as for symptomatic relief. Conventional photodynamic therapy (c-PDT) is indicated when AKs are multiple or confluent and if patients respond poorly or are unable to tolerate other therapies. c-PDT is limited by the field size that can be treated in single sessions and can cause significant discomfort...
October 27, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27778164/effect-of-a-pre-treatment-educational-video-in-improving-patient-satisfaction-with-5-fluorouracil-treatment-for-actinic-keratoses-a-randomized-controlled-trial
#19
Oma N Agbai, Parastoo Davari, Jennifer Johnson, April Armstrong, Nasim Fazel
INTRODUCTION: Patient treatment satisfaction and adherence may be affected by the initial understanding of outcomes in the treatment of actinic keratoses with 5-fluorouracil 5% cream (5-FU). Pre-treatment educational videos may optimize this understanding. The objective of this study was to determine whether prospective patient viewing of an educational video delineating treatment effects and expectations improves patient satisfaction and treatment completion rates for the treatment of actinic keratoses with 5-FU...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27717097/p16-immunostaining-in-keratinocytic-neoplasia-in-organ-transplant-recipients-bowen-s-disease-shows-a-characteristic-pattern
#20
Roel E Genders, Samuel Beck, Jan Nico Bouwes Bavinck, Henk A M van den Munckhof, Stijn T P Kouwenhoven, Maurits N C de Koning, Frank R de Gruijl, David Jenkins, Rein Willemze, Koen D Quint
BACKGROUND: For selecting therapy, it is important to distinguish different types of keratinocytic neoplasia. It is sometimes difficult to make histopathologic diagnosis, especially in organ transplant recipients (OTR) who develop numerous lesions. METHODS: To investigate p16 immunostaining in different types of keratinocytic neoplasia in OTR, we studied 59 actinic keratoses (AK), 51 Bowen' s disease (BD), 63 squamous cell carcinomas (SCC), 16 benign keratotic lesions (BKL) from 31 OTR patients and 25 controls (eczema and psoriasis)...
January 2017: Journal of Cutaneous Pathology
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