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https://www.readbyqxmd.com/read/29669318/neurod-expression-in-podocytes-and-interrelationships-with-nephrin-at-both-nuclear-and-cytoplasmic-sites
#1
Silvia Armelloni, Masami Ikehata, Deborah Mattinzoli, Min Li, Carlo Maria Alfieri, Mariapia Rastaldi, Piergiorgio Messa
Background/Aims The research of genes implicated in kidney glomerular function, eliciting cell fate program, is always at the forefront in nephrological studies. Several neurological molecules have been recently the object of study not only for their involvement in the central nervous system differentiation but also for their importance in the functionality of other organs and for mature phenotype, as in kidney. NeuroD, in CNS, is related to two functional roles, the early survival and the differentiation. The aim of our study was to ascertain the presence of NeuroD transcription factor in glomeruli and to understand which targets and mechanisms NeuroD controls...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29667154/reliability-and-feasibility-of-gait-initiation-centre-of-pressure-excursions-using-a-wii-%C3%A2-balance-board-in-older-adults-at-risk-of-failing
#2
James Lee, Graham Webb, Adam P Shortland, Rebecca Edwards, Charlotte Wilce, Gareth D Jones
BACKGROUND: Impairments in dynamic balance have a detrimental effect in older adults at risk of falls (OARF). Gait initiation (GI) is a challenging transitional movement. Centre of pressure (COP) excursions using force plates have been used to measure GI performance. The Nintendo Wii Balance Board (WBB) offers an alternative to a standard force plate for the measurement of CoP excursion. AIMS: To determine the reliability of COP excursions using the WBB, and its feasibility within a 4-week strength and balance intervention (SBI) treating OARF...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29666111/decreasing-an-offloading-device-s-size-and-offsetting-its-imposed-limb-length-discrepancy-lead-to-improved-comfort-and-gait
#3
Ryan T Crews, Joseph Candela
OBJECTIVE: Patient adherence is a challenge in offloading diabetic foot ulcers (DFUs) with removable cast walkers (RCWs). The size and weight of an RCW, changes to gait, and imposed limb length discrepancies may all discourage adherence. This study sought to determine whether RCW size and provision of a contralateral limb lift affected users' comfort and gait. RESEARCH DESIGN AND METHODS: Twenty-five individuals at risk for DFUs completed several 20-m walking trials under five footwear conditions: bilateral standardized shoes, a knee-high RCW with shoe with or without an external shoe lift contralaterally, and an ankle-high RCW with shoe with or without an external shoe lift contralaterally...
April 17, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29660954/usability-of-the-thera-band%C3%A2-to-improve-foot-drop-in-stroke-survivors
#4
SunHae Song, JungHee Park, GyuDong Song, SeulGi Lee, YoHan Jo, MinKyung Jin, DongGeon Lee, SunHye Jung, SoungKyun Hong, SeungHoo Lee, SeungHyeon Pyo, GyuChang Lee
BACKGROUND: Stroke survivors show "foot drop", dragging their toes on the ground in the swing phase of gait. Ineffective ankle dorsiflexion may result in an abnormal gait pattern. OBJECTIVE: The purpose of this study was to investigate the effect of ankle Thera-Band® use on gait patterns in stroke survivors. METHODS: Gait data were collected in eight subjects who had had strokes using gait analysis system, both with and without the Thera-Band®...
April 7, 2018: NeuroRehabilitation
https://www.readbyqxmd.com/read/29658528/gait-changes-in-patients-after-reconstruction-of-facial-bones-with-fibula-and-iliac-crest-free-vascularized-flaps
#5
Małgorzata Syczewska, Romuald Krajewski, Monika Kirwil, Ewa Szczerbik, Małgorzata Kalinowska
PURPOSE: Patients with malignant tumours of the oral cavity require its surgical removal and reconstruction of the bone and soft tissues. The grafts are obtained either from leg (fibula) or pelvis (iliac crest). The removal of grafts from the locomotor apparatus can impair the gait. The aim of this study was to find out how the localization of donor site influences the gait pattern. METHODS: Results obtained for 30 patients were analyzed (16 fibula graft, 14 iliac crest graft)...
2018: Acta of Bioengineering and Biomechanics
https://www.readbyqxmd.com/read/29655809/acute-limb-ischemia-in-an-8-year-old-patient-case-report
#6
Young Erben, Samuel M Miller, Brandon J Sumpio, Brian J Dillon, Alfred I Lee, Peter Blume, Bauer E Sumpio, Carlos Mena-Hurtado
We report the case of an 8-year-old patient with a history of nephrotic syndrome (NS), who presented to the emergency department (ED) with right foot pain. The patient's mother described intermittent pain that woke her son from sleep and was accompanied by the foot turning purple and becoming cold to touch. Physical exam revealed capillary refill of over ten seconds in the right and less than two seconds in the left foot. Ankle-brachial indices (ABI) were 0.0 on the right and 0.96 on the left. The patient was admitted and started on therapeutic intravenous heparin...
April 12, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29649932/optimal-tube-length-of-orotracheal-intubation-for-mice
#7
Nobuyuki Nosaka, Timothy R Crother, Shuang Chen, Moshe Arditi, Kenichi Shimada
Endotracheal tube (ETT) management is an essential technique in handling mice with mechanical ventilators. Malposition into bronchi causes not only lethal complications for them but also less efficient mechanical ventilation. However, in general, it is difficult to know whether the ETT is placed with appropriate depth into the trachea of mice. We measured the distance from incisors to the bifurcation of trachea of multiple mice, and created a new estimation formula to obtain the suitable ETT length for mice with a body weight range from 17 g to 25 g: length (mm) = 0...
January 1, 2018: Laboratory Animals
https://www.readbyqxmd.com/read/29649707/specific-smartphone-usage-and-cognitive-performance-affect-gait-characteristics-during-free-living-and-treadmill-walking
#8
Daniel Niederer, Anke Bumann, Yvonne Mühlhauser, Mareike Schmitt, Katja Wess, Tobias Engeroff, Jan Wilke, Lutz Vogt, Winfried Banzer
BACKGROUND: Mobile phone tasks like texting, typing, and dialling during walking are known to impact gait characteristics. Beyond that, the effects of performing smartphone-typical actions like researching and taking self-portraits (selfie) on gait have not been investigated yet. RESEARCH QUESTION: We aimed to investigate the effects of smartphone usage on relevant gait characteristics and to reveal potential association of basic cognitive and walking plus smartphone dual-task abilities...
April 6, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29649584/molecular-cloning-expression-and-biochemical-characterization-of-hemoglobin-gene-from-ark-shell-scapharca-broughtonii
#9
Qing Zhao, Biao Wu, Zhihong Liu, Xiujun Sun, Liqing Zhou, Aiguo Yang, Gaowei Zhang
Hemoglobin, the main component of haemolymph, is widely distributed in animals. Although its important oxygen transport functions has been extensively reported, studies on the immune function of hemoglobin in mollusc are few. Research on immune of hemoglobin of ark shell Scapharca broughtonii attracted more and more attention due to its ownership of erythrocyte comparing with many other shellfish. In this study, the hemoglobin cDNA of S. broughtonii was cloned by EST and RACE methods (named as SbHb). Sequence analysis revealed that the cDNA was 946 bp in length, including an open reading frame (ORF) of 459 bp which encoded a polypeptide of 152 amino acid residues, and a 5'-untranslated region (UTR) of 313 bp, a 3'-UTR of 174 bp...
April 9, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29627500/objective-measures-of-unobstructed-walking-and-obstacle-avoidance-in-parkinson-s-disease-subtypes
#10
Diego Orcioli-Silva, Rodrigo Vitório, Ellen Lirani-Silva, Paulo Cezar Rocha Santos, Victor Spiandor Beretta, Lilian Teresa Bucken Gobbi
BACKGROUND: Objective measures of gait in Parkinson's disease (PD) patients according to motor subtypes are not yet fully understood. Although recent advances have been made for unobstructed walking, further work is required on locomotor tasks challenging postural stability, such as obstacle avoidance. RESEARCH QUESTION: This study aimed to investigate the influence of PD motor subtypes on objective measures of locomotion during unobstructed walking and obstacle avoidance...
March 30, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29626884/fate-of-the-open-shell-singlet-ground-state-in-the-experimentally-accessible-acenes-a-quantum-monte-carlo-study
#11
Nicolas Dupuy, Michele Casula
By means of the Jastrow correlated antisymmetrized geminal power (JAGP) wave function and quantum Monte Carlo (QMC) methods, we study the ground state properties of the oligoacene series, up to the nonacene. The JAGP is the accurate variational realization of the resonating-valence-bond (RVB) ansatz proposed by Pauling and Wheland to describe aromatic compounds. We show that the long-ranged RVB correlations built in the acenes' ground state are detrimental for the occurrence of open-shell diradical or polyradical instabilities, previously found by lower-level theories...
April 7, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29626046/using-the-oxford-foot-model-to-determine-the-association-between-objective-measures-of-foot-function-and-results-of-the-aofas-ankle-hindfoot-scale-and-the-foot-function-index-a-prospective-gait-analysis-study-in-germany
#12
Tanja Kostuj, Felix Stief, Kirsten Anna Hartmann, Katharina Schaper, Mohammad Arabmotlagh, Mike H Baums, Andrea Meurer, Frank Krummenauer, Sebastian Lieske
OBJECTIVE: After cross-cultural adaption for the German translation of the Ankle-Hindfoot Scale of the American Orthopaedic Foot and Ankle Society (AOFAS-AHS) and agreement analysis with the Foot Function Index (FFI-D), the following gait analysis study using the Oxford Foot Model (OFM) was carried out to show which of the two scores better correlates with objective gait dysfunction. DESIGN AND PARTICIPANTS: Results of the AOFAS-AHS and FFI-D, as well as data from three-dimensional gait analysis were collected from 20 patients with mild to severe ankle and hindfoot pathologies...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29623685/specific-bioactive-collagen-peptides-petagile-%C3%A2-as-supplement-for-horses-with-osteoarthritis-a-two-centred-study
#13
B Dobenecker, S Reese, W Jahn, M Schunck, J Hugenberg, H Louton, S Oesser
The aim of the study was to evaluate the clinical efficacy of specific bioactive collagen peptides (BCP), here administered orally as PETAGILE® , on horses with mild to moderate, naturally occurring osteoarthritis. Data from a two-centred pilot study were used for the meta-analysis. Thirty-eight privately owned horses of various breeds were available. In one centre, 18 of these patients (6 ± 3 years; 519 ± 100 kg BW) received either 25 g (n = 6) or 50 g (n = 12) BCP/day orally for 12 weeks. In the second centre, 20 horses (18 ± 4 years; 413 ± 94 kg BW) received either a placebo (control; n = 10) or 25 g BCP/day...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29616845/lateralizing-calcaneal-osteotomies-and-their-effect-on-calcaneal-alignment-a-three-dimensional-digital-model-analysis
#14
Elizabeth A Cody, Andrew P Kraszewski, Matthew S Conti, Scott J Ellis
BACKGROUND: Few authors have directly compared multiple types of lateralizing calcaneal osteotomies (LCOs) in terms of their ability to achieve deformity correction. The aim of this research was to use a digital model of a varus hindfoot to compare 4 different LCOs in terms of deformity correction and amount of tuberosity lateralization required. The authors hypothesis was that osteotomies involving a wedge resection would achieve greater correction with less lateralization. METHODS: A weightbearing computed tomographic scan of a patient with a varus hindfoot deformity was used to construct a 3-dimensional digital model of the hindfoot, preserving weightbearing alignment...
April 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29616085/assessment-of-telomerase-activity-in-leukocytes-of-type-2-diabetes-mellitus-patients-having-or-not-foot-ulcer-possible-correlation-with-other-clinical-parameters
#15
Dimitrios Baltzis, Evangelia Meimeti, Maria G Grammatikopoulou, Matthieu Roustit, Eleni Mavrogonatou, Dimitris Kletsas, Smaragda Efraimidou, Christos Manes, Taxiarchis K Nikolouzakis, John Tsiaoussis, Aristides M Tsatsakis, Demetrios A Spandidos, Christina-Maria Trakatelli, Nikolaos Drakoulis
Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: Νon-ulcer group (N=58) and ulcer group (N=32)...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29606023/equinus-correction-during-multilevel-surgery-in-adults-with-cerebral-palsy
#16
Cornelia Putz, Eva Maria Mertens, Sebastian I Wolf, Andreas Geisbüsch, Mirjam Niklasch, Simone Gantz, Leonhard Döderlein, Thomas Dreher, Matthias C Klotz
BACKGROUND: Equinus foot deformity constitutes a common gait disorder in ambulatory adults with bilateral spastic cerebral palsy (BSCP). The outcome after intramuscular aponeurotic lengthening in the context of single-event multilevel surgery (SEMLS) in adulthood has not been investigated. METHODS: We followed a group of 31 ambulatory adults with BSCP and equinus who underwent SEMLS including gastrocnemius-soleus intramuscular aponeurotic recession or Achilles tendon lengthening...
March 1, 2018: Foot & Ankle International
https://www.readbyqxmd.com/read/29602476/ultrasound-estimates-of-achilles-tendon-exhibit-unexpected-shortening-during-ankle-plantarflexion
#17
Emily S Matijevich, Lauren M Branscombe, Karl E Zelik
The purpose of this study was to investigate Achilles tendon (AT) length changes during a series of tasks that involved combinations of higher/lower force, and larger/smaller length changes of the medial gastrocnemius muscle-tendon unit (MTU). We sought to determine if common ultrasound-based estimates of AT length change were consistent with expectations for a passive elastic tendon acting in series with a muscle. We tested 8 healthy individuals during restricted joint calf contractions (high force, low displacement), ankle dorsi-/plantar-flexion (DF/PF) with the foot in the air (low force, high displacement), and heel raises (high force, high displacement)...
March 15, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29602474/quantification-of-gait-parameters-with-inertial-sensors-and-inverse-kinematics
#18
Kai Bötzel, Alberto Olivares, João Paulo Cunha, Juan Manuel Górriz Sáez, Robin Weiss, Annika Plate
Measuring human gait is important in medicine to obtain outcome parameter for therapy, for instance in Parkinson's disease. Recently, small inertial sensors became available which allow for the registration of limb-position outside of the limited space of gait laboratories. The computation of gait parameters based on such recordings has been the subject of many scientific papers. We want to add to this knowledge by presenting a 4-segment leg model which is based on inverse kinematic and Kalman filtering of data from inertial sensors...
March 15, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29600331/influence-of-fascicle-length-on-twitch-potentiation-of-the-medial-gastrocnemius-across-three-ankle-angles
#19
Samantha L Kuzyk, Rowan R Smart, Carey L Simpson, Andrey Fedorov, Jennifer M Jakobi
PURPOSE: Length dependence of post-activation potentiation (PAP) is a well-established phenomenon in animal models but less certain in intact whole human muscles. Recent advances in B-mode ultrasonography provide real-time imaging and evaluation of human muscle fascicles in vivo, thus removing the assumption that joint positioning alters fascicle length and influences the extent of PAP. The purpose of this study was to determine whether a conditioning maximal voluntary contraction (MVC) would influence the return of medial gastrocnemius (MG) fascicles to baseline length and alter the extent of twitch potentiation between three ankle positions...
March 30, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29595900/a-perioperative-approach-to-increase-limb-salvage-when-treating-foot-ulcers-in-patients-with-diabetes
#20
Raelina S Howell, Theresa Criscitelli, Jon S Woods, Brian M Gillette, Harold Brem, Scott Gorenstein
Foot ulceration in patients with diabetes increases the risk of lower extremity amputation. Major amputations produce substantial adverse consequences, increase length of hospital stay, diminish quality of life, and increase mortality. In this article, we describe approaches that decrease amputations and improve the quality of life for patients with diabetes and foot ulcers. We highlight the role of the perioperative nurse, who is essential to providing optimal patient care in the perioperative period. Perioperative care of patients with diabetes involves providing optimal surveillance for a break in the skin of the foot, screening for neuropathy, following guidelines for foot ulcer infections, preparing for pathophysiology-based debridement, using adjuvant therapies, and offloading the patient's affected foot...
April 2018: AORN Journal
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