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https://www.readbyqxmd.com/read/28916892/precision-in-robotic-rectal-surgery-using-the-da-vinci-xi-system-and-integrated-table-motion-a-technical-note
#1
Sofoklis Panteleimonitis, Mick Harper, Stuart Hall, Nuno Figueiredo, Tahseen Qureshi, Amjad Parvaiz
Robotic rectal surgery is becoming increasingly more popular among colorectal surgeons. However, time spent on robotic platform docking, arm clashing and undocking of the platform during the procedure are factors that surgeons often find cumbersome and time consuming. The newest surgical platform, the da Vinci Xi, coupled with integrated table motion can help to overcome these problems. This technical note aims to describe a standardised operative technique of single docking robotic rectal surgery using the da Vinci Xi system and integrated table motion...
September 15, 2017: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/28914194/diabetic-retinopathy-recent-updates-on-different-biomarkers-and-some-therapeutic-agents
#2
Amjad Ali Khan, Arshad Husain Rahmani, Yousef Homood Aldebasi
BACKGROUND: Diabetic Retinopathy is a leading cause of sight-threatening complication, which occurs due to a number of physiological and metabolic abnormalities during later stages of diabetes. Many of these abnormal changes are consistent with altered oxidative stress, inflammation, genetic set up, advanced glycation end products, and hematological changes. So the altered levels of different biomolecules related to these changes serve as important biomarkers to assess better evaluation and early treatment of this disease...
September 15, 2017: Current Diabetes Reviews
https://www.readbyqxmd.com/read/28910429/evaluation-and-management-of-unilateral-congenital-ptosis-in-a-healthy-child
#3
Adam D Baim, Grace E Dunbar, Amjad Ahmad
No abstract text is available yet for this article.
September 14, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28904393/microrna-pharmacogenomics-based-integrated-model-of-mir-17-92-cluster-in-sorafenib-resistant-hcc-cells-reveals-a-strategy-to-forestall-drug-resistance
#4
Faryal Mehwish Awan, Anam Naz, Ayesha Obaid, Aqsa Ikram, Amjad Ali, Jamil Ahmad, Abdul Khaliq Naveed, Hussnain Ahmed Janjua
Among solid tumors, hepatocellular carcinoma (HCC) emerges as a prototypical therapy-resistant tumor. Considering the emerging sorafenib resistance crisis in HCC, future studies are urgently required to overcome resistance. Recently noncoding RNAs (ncRNAs) have emerged as significant regulators in signalling pathways involved in cancer drug resistance and pharmacologically targeting these ncRNAs might be a novel stratagem to reverse drug resistance. In the current study, using a hybrid Petri net based computational model, we have investigated the harmonious effect of miR-17-92 cluster inhibitors/mimics and circular RNAs on sorafenib resistant HCC cells in order to explore potential resistance mechanisms and to identify putative targets for sorafenib-resistant HCC cells...
September 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28903842/effect-of-early-%C3%A2-3-mets-metabolic-equivalent-of-tasks-of-physical-activity-on-patient-s-outcome-after-cardiac-surgery
#5
Muhammad Iqbal Tariq, Asif Ali Khan, Zara Khalid, Hania Farheen, Furqan Ahmed Siddiqi, Imran Amjad
OBJECTIVE: To determine the effect of <3 Mets (Metabolic Equivalent of Tasks) of physical activity on zero postoperative days for improving hemodynamic and respiratory parameters of patients after cardiac surgeries. STUDY DESIGN: Randomized control trial. PLACE AND DURATION OF STUDY: BARMWTHospital, Rawalpindi, from March to August 2015. METHODOLOGY: Arandomized controlled trial was conducted on 174 CABG and valvular heart disease patients undergoing cardiac surgical procedures...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28901264/inhibition-of-proliferation-and-induction-of-apoptosis-by-thymoquinone-via-modulation-of-tgf-family-p53-p21-and-bcl-2%C3%AE-in-leukemic-cells
#6
Mona Diab Assaf, Josiane Semaan, Marwan El-Sabban, Soad K Al-Jaouni, Rania Azar, Mohammad Amjad Kamal, Steve Harakeh
The rationale of the current study was to investigate whether the inverse association between vitamin D deficiency and parathyroid hormone levels is age-dependent and whether it has any role in modulating renal function and insulin resistance. To test this hypothesis, we have carried out a hospital based study enrolling 848 subjects (558 men and 290 women) with the mean age of 50.9±15.9 y. Vitamin D deficiency was predominant irrespective of age group (p=0.21) and gender (p=0.12). An inverse association between vitamin D and PTH was observed (r= -0...
September 12, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28901256/editorial-frontier-view-on-drug-discoveries-for-different-diseases-part-ii
#7
EDITORIAL
Mohammad Amjad Kamal
No abstract text is available yet for this article.
2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28894539/prevalence-risk-factors-and-character-of-abdominal-hernia-in-arar-city-northern-saudi-arabia-in-2017
#8
Abdulmajeed AhmedAlenazi, Mahmoud Mohammed Alsharif, Malik Azhar Hussain, Naif Gharbi Alenezi, Abdulrhman Ahmed Alenazi, Shouq Amjad Almadani, Nour Homoud Alanazi, Jazzaa Hammad Alshammari, Alwaleed Oqab Altimyat, Tariq Hulayyil Alanazi
BACKGROUND: Abdominal wall hernias are a very common surgical condition affecting all ages and both sexes. The main risk factors of hernias include pregnancy, weight lifting, constipation, and weight gain. OBJECTIVE: The aim of this study was to determine the prevalence and risk factors of abdominal hernias, their causes, treatment and complications among both sexes of the Arar population (Saudi Arabia). METHODS: A cross-sectional study was conducted among 1,567 adults living in Arar city in 2017...
July 2017: Electronic Physician
https://www.readbyqxmd.com/read/28886077/exploration-of-ethno-medicinal-knowledge-among-rural-communities-of-pearl-valley-rawalakot-district-poonch-azad-jammu-and-kashmir
#9
Humaira Shaheen, Mirza Faisal Qaseem, Muhammad Shoaib Amjad, Piero Bruschi
BACKGROUND: Medicinal plants are the basic source of health care in the Pearl Valley District Poonch, Azad Jammu, and Kashmir. The basic aim of present study was to record information about the use of plants in herbal preparation and quantification of recorded data. MATERIALS AND METHODS: The research was conducted with the null hypothesis that there was no differential distribution of knowledge among the communities between genders and among different age groups in the study area and across cultural medicinal uses of the plants are similar...
2017: PloS One
https://www.readbyqxmd.com/read/28883533/systems-identification-and-characterization-of-cell-wall-reassembly-and-degradation-related-genes-in-glycine-max-l-merill-a-bioenergy-legume
#10
Muhammad Amjad Nawaz, Hafiz Mamoon Rehman, Muhammad Imtiaz, Faheem Shehzad Baloch, Jeong Dong Lee, Seung Hwan Yang, Soo In Lee, Gyuhwa Chung
Soybean is a promising biomass resource for generation of second-generation biofuels. Despite the utility of soybean cellulosic biomass and post-processing residues in biofuel generation, there is no comprehensive information available on cell wall loosening and degradation related gene families. In order to achieve enhanced lignocellulosic biomass with softened cell walls and reduced recalcitrance, it is important to identify genes involved in cell wall polymer loosening and degrading. Comprehensive genome-wide analysis of gene families involved in cell wall modifications is an efficient stratagem to find new candidate genes for soybean breeding for expanding biofuel industry...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28878208/hsp90-inhibition-enhances-cancer-immunotherapy-by-upregulating-interferon-response-genes
#11
Rina M Mbofung, Jodi A McKenzie, Shruti Malu, Min Zhang, Weiyi Peng, Chengwen Liu, Isere Kuiatse, Trang Tieu, Leila Williams, Seram Devi, Emily Ashkin, Chunyu Xu, Lu Huang, Minying Zhang, Amjad H Talukder, Satyendra C Tripathi, Hiep Khong, Nikunj Satani, Florian L Muller, Jason Roszik, Timothy Heffernan, James P Allison, Gregory Lizee, Sam M Hanash, David Proia, Rodabe Amaria, R Eric Davis, Patrick Hwu
T-cell-based immunotherapies are promising treatments for cancer patients. Although durable responses can be achieved in some patients, many patients fail to respond to these therapies, underscoring the need for improvement with combination therapies. From a screen of 850 bioactive compounds, we identify HSP90 inhibitors as candidates for combination with immunotherapy. We show that inhibition of HSP90 with ganetespib enhances T-cell-mediated killing of patient-derived human melanoma cells by their autologous T cells in vitro and potentiates responses to anti-CTLA4 and anti-PD1 therapy in vivo...
September 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/28875928/the-association-of-hla-dqb1-0602-but-not-hla-drb1-15-with-obstructive-sleep-apnea
#12
Suleiman M Momany, Thamer A Al-Qatarneh, Yousef S Khader, Nizar M Abu-Harfeil, Ammar K Daoud, Amjad A Mahasneh
PURPOSE: Obstructive sleep apnea (OSA) is a sleep breathing disorder with unclear multifactorial pathogenesis. This study aimed to investigate the association between OSA and two human leukocyte antigens (HLA) alleles; DQB1*0602 and DRB1*15. METHODS: Forty patients with OSA and 40 control subjects were enrolled in the study. OSA diagnosis was made utilizing the Apnea-Hypopnea Index (AHI)≥5 in overnight polysomnography (PSG). AHI was also used to determine OSA severity...
August 29, 2017: Clinical and Investigative Medicine. Médecine Clinique et Experimentale
https://www.readbyqxmd.com/read/28857623/ats-core-curriculum-2017-part-ii-pediatric-pulmonary-medicine
#13
Paul E Moore, Jason T Poston, Debra Boyer, Emily Barsky, Jonathan Gaffin, Kathleen B Boyne, Kristie R Ross, Laura Beth Mann Dosier, Timothy J Vece, Alicia M Casey, Sebastian K Welsh, J Wells Logan, Edward G Shepherd, Pelton A Phinzy, Howard B Panitch, Christina M Papantonakis, Eric D Austin, Amir B Orandi, Maleewan Kitcharoensakkul, Mark K Abe, Amjad Horani, Jordan S Rettig, Jessica Pittman
No abstract text is available yet for this article.
August 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28846016/impact-of-merger-and-acquisition-on-university-performance
#14
Amjad Mohamadi Bolbanabad, Ali Mohammad Mosadeghrad, Mohammad Arab, Reza Majdzadeh
PURPOSE: Merger and acquisitions (M&A) widen access to higher education, improve quality of teaching and research, and increase efficiency of higher education institutions. Three big medical universities in Iran merged in 2010. The purpose of this study was to highlight the impact of this acquisition on the performance of Tehran University of Medical Sciences. METHODS: This qualitative study was conducted using semi-structured in-depth interviews with 60 participants from April 2015 to November 2015...
August 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28843225/managing-the-axilla-in-early-breast-cancer-impact-of-acosog-z0011-trial-in-changing-practices-in-a-low-middle-income-country
#15
Awais Amjad Malik, Namra Urooj, Romaisa Shamim, Mariam Salim, Razia Bano, Zulqurnain Chaudhry, Huma Majeed Khan, Amina Iqbal Khan
Objective: To determine the impact of the trial on surgeon practice patterns at our institution. Methodology: A comparison of patients undergoing surgery for early breast cancer before and after the implementation of the new guidelines was done. We adopted the new guidelines in April 2015. Patients meeting Z0011 inclusion criteria were identified. For group A (Pre Z0011) patients operated between Jan to Dec 2013 were studied. And for Group B (Post Z0011) patients operated between July 2014 to Jun 2015 were included...
August 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28835881/reasons-for-operation-cancellations-at-a-teaching-hospital-prioritizing-areas-of-improvement
#16
Mahmoud Abu Abeeleh, Tareq M Tareef, Amjad Bani Hani, Nader Albsoul, Omar Q Samarah, M S ElMohtaseb, Musa Alshehabat, Zuhair Bani Ismail, Omar Alnoubani, Salameh S Obeidat, Sami Abu Halawa
PURPOSE: To report rates of and reasons for operation cancellation, and to prioritize areas of improvement. METHODS: Retrospective data were extracted from the monthly reports of cancelled listed operations. Data on 14 theatres were collected by the office of quality assurance at Jordan University Hospital from August 2012 to April 2016. Rates and reasons for operation cancellation were investigated. A Pareto chart was constructed to identify the reasons of highest priority...
August 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28831925/diabetes-mellitus-and-male-aging-pharmacotherapeutics-and-clinical-implications
#17
Swathi Putta, Ilaria Peluso, Nagendra Sastry Yarla, Eswar Kumar Kilari, Anupam Bishayee, Da-Yong Lu, George E Barreto, Ghulam Md Ashraf, Luciana Scotti, Marcus T Scotti, Rajeev K Singla, Thonos Alexiou, Atanas G Atanasov, Vadim V Tarasov, P Veera Bramhachari, Sarat Babu Imandi, Madhuri Chintala, Bechan Sharma, Marcella Reale, Rosanna Filosa, Gjumrakch Aliev, Mohammad Amjad Kamal
Andropause or male menopause is defined as androgen decline and onset of hypogonadism in the aging male. Testosterone deficiency in adult male is associated with diabetes mellitus, coronary artery disease, and heart failure. Type 2 diabetic male patients aged above 30 years showed low testosterone levels which is common in diabetic men and had symptoms of hypogonadism. Male sexual dysfunction among diabetic patients can include disorders of libido, ejaculatory problems, and erectile dysfunctions are common among people with diabetes, particularly in older men who had diabetes for years...
August 22, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28830526/prevalence-of-hepatitis-c-virus-genotypes-and-potential-transmission-risks-in-malakand-khyber-pakhtunkhwa-pakistan
#18
Nausheen Nazir, Muhammad Rasul Jan, Amjad Ali, Muhammad Asif, Muhammad Idrees, Mohammad Nisar, Muhammad Zahoor, Naser M Abd El-Salam
BACKGROUND: Hepatitis C virus (HCV) is a leading cause of chronic liver disease and frequently progresses towards liver cirrhosis and Hepatocellular Carcinoma (HCC). This study aimed to determine the prevalence of HCV genotypes and their association with possible transmission risks in the general population of Malakand Division. METHODOLOGY: Sum of 570 serum samples were collected during March 2011 to January 2012 from suspected patients visited to different hospitals of Malakand...
August 22, 2017: Virology Journal
https://www.readbyqxmd.com/read/28825529/therapeutic-strategies-of-clustered-regularly-interspaced-palindromic-repeats-cas-systems-for-different-viral-infections
#19
Braira Wahid, Sana Usman, Amjad Ali, Komal Saleem, Shazia Rafique, Zara Naz, Hafiz Ahsan Ashfaq, Muhammad Idrees
The clustered regularly interspaced palindromic repeats (CRISPR)/Cas systems have rapidly transitioned from intriguing prokaryotic defense systems to an efficient therapeutic tool. This cutting-edge technology is currently revolutionizing to combat hostile viruses because of its reproducibility, high potency, ease of use, limited off-target activity, and development of quick immune response against viruses. CRISPR gene editing technology eliminates the virus by breaking the DNA that ultimately halts viral replication...
August 21, 2017: Viral Immunology
https://www.readbyqxmd.com/read/28823034/effect-of-pristine-and-functionalized-single-and-multi-walled-carbon-nanotubes-on-co2-separation-of-mixed-matrix-membranes-based-on-polymers-of-intrinsic-microporosity-pim-1-a-molecular-dynamics-simulation-study
#20
Karim Golzar, Hamid Modarress, Sepideh Amjad-Iranagh
Molecular dynamics (MD) and grand canonical Monte Carlo (GCMC) simulations were conducted to investigate the transport properties of carbon dioxide, methane, nitrogen, and oxygen through pure and mixed matrix membranes (MMMs) based on polymers of intrinsic microporosity (PIM-1). For this purpose, first, 0.5 to 3 wt% of pristine single-walled carbon nanotube (p-SWCNT) and multi-walled carbon nanotube (p-MWCNT) were embedded into the pure PIM-1, and then for better dispersion of CNT particles into the polymer matrix and to improve the performance of the resulting MMMs, polyethylene glycol (PEG) functionalized SWCNT and MWCNT (f-SWCNT and f-MWCNT, respectively) were loaded...
August 19, 2017: Journal of Molecular Modeling
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