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https://www.readbyqxmd.com/read/28193166/vacsol-a-high-throughput-in-silico-pipeline-to-predict-potential-therapeutic-targets-in-prokaryotic-pathogens-using-subtractive-reverse-vaccinology
#1
Muhammad Rizwan, Anam Naz, Jamil Ahmad, Kanwal Naz, Ayesha Obaid, Tamsila Parveen, Muhammad Ahsan, Amjad Ali
BACKGROUND: With advances in reverse vaccinology approaches, a progressive improvement has been observed in the prediction of putative vaccine candidates. Reverse vaccinology has changed the way of discovery and provides a mean to propose target identification in reduced time and labour. In this regard, high throughput genomic sequencing technologies and supporting bioinformatics tools have greatly facilitated the prompt analysis of pathogens, where various predicted candidates have been found effective against certain infections and diseases...
February 13, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28192466/descriptive-study-of-plant-resources-in-the-context-of-the-ethnomedicinal-relevance-of-indigenous-flora-a-case-study-from-toli-peer-national-park-azad-jammu-and-kashmir-pakistan
#2
Muhammad Shoaib Amjad, Mirza Faisal Qaeem, Israr Ahmad, Sami Ullah Khan, Sunbal Khalil Chaudhari, Nafeesa Zahid Malik, Humaira Shaheen, Arshad Mehmood Khan
BACKGROUND: This paper presents the first quantitative ethnobotanical study of the flora in Toli Peer National Park of Azad Jammu and Kashmir, Pakistan. Being a remote area, there is a strong dependence by local people on ethnobotanical practices. Thus, we attempted to record the folk uses of the native plants of the area with a view to acknowledging and documenting the ethnobotanical knowledge. The aims of the study were to compile an inventory of the medicinal plants in the study area and to record the methods by which herbal drugs were prepared and administered...
2017: PloS One
https://www.readbyqxmd.com/read/28186369/synthesis-and-mechanistic-studies-of-curcumin-analogs-based-oximes-as-potential-anticancer-agents
#3
Hua-Li Qin, Jing Leng, Bahaa G M Youssif, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja, Muhammad Ajaz Hussain, Zahid Hussain, Syeda Naveed Kazmi, Syed Nasir Abbas Bukhari
The incidence of cancer can be decreased by chemoprevention using either natural or synthetic agents. Apart from synthetic compounds, numerous natural products have exhibited promising potential to inhibit carcinogenesis in vivo. In this study, α, β-unsaturated carbonyl based anticancer compounds were used as starting materials to synthesize new oxime analogs. The findings from the antiproliferative assay using seven different human cancer cell lines provided a clear picture of structure-activity relationship...
February 10, 2017: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/28183850/deltex-1-mutations-predict-poor-survival-in-diffuse-large-b-cell-lymphoma
#4
Leo Meriranta, Annika Pasanen, Riku Louhimo, Alejandra Cervera, Amjad Alkodsi, Matias Autio, Minna Taskinen, Ville Rantanen, Marja-Liisa Karjalainen-Lindsberg, Harald Holte, Jan Delabie, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
No abstract text is available yet for this article.
February 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28176640/inhibition-of-butyrylcholinesterase-with-fluorobenzylcymserine-an-experimental-alzheimer-s-drug-candidate-validation-of-enzoinformatics-results-by-classical-and-innovative-enzyme-kinetic-analyses
#5
Mohammad Amjad Kamal, Shazi Shakil, Muhammad S Nawaz, Qian-Sheng Yu, Harold W Holloway, Y Tan, Xianqin Qu, Nigel H Greig
Selective butyrylcholinesterase (BuChE)-inhibition, increases acetylcholine (ACh) levels. In rodents, this inhibition is known to boost cognition. Also, this occurs without the typical unwanted effects of acetylcholinesterase-inhibitors or AChE-Is. The novel compound, fluorobenzylcymserine (FBC), is derived from our effort to design a selective BuChE-inhibitor. Also, we wanted to check whether butyrylcholinesterase-inhibitors (BuChE-Is) possessed an edge over AChE-Is in Alzheimer's disease (AD) in terms of efficacy and/or tolerance...
February 7, 2017: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/28164765/commonalities-in-biological-pathways-genetics-and-cellular-mechanism-between-alzheimer-disease-and-other-neurodegenerative-diseases-an-in-silico-updated-overview
#6
Khurshid Ahmad, Mohammad Hassan Baig, Gohar Mushtaq, Mohammad Amjad Kamal, Nigel H Greig, Inho Choi
Alzheimer's disease (AD) is the most common and well-studied neurodegenerative disease (ND). Biological pathways, pathophysiology and genetics of AD show commonalities with other NDs viz. Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Huntington's disease (HD), Prion Disease and Dentatorubral-pallidoluysian atrophy (DRPLA). Many of the NDs, sharing the common features and molecular mechanisms suggests that pathology may be directly comparable and be implicated in disease prevention and development of highly effective therapies...
February 3, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28164752/exploration-of-various-proteins-for-the-treatment-of-alzheimer-s-disease
#7
Badar Ul Islam, Syed Kashif Zaidi, Mohammad Amjad Kamal, Shams Tabrez
Alzheimer's disease (AD) is an irreversible multifaceted neurodegenerative disorder that gradually degrades neuronal cells. It is the most frequent cause of memory loss and dementia in elderly individuals worldwide. The extracellular deposition of beta amyloid (Aβ), intracellular neurofibrillary tangles (NFTs) retention, neuronal decline and neurotransmitter system derangement has been suggested as the patho-physiological marker of this devastated disease. In view of limited treatment option and success rate, there is an urgent need to explore the vast array of proteomes for the management of AD...
February 3, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28160703/spatial-distribution-and-risk-assessment-of-heavy-metals-in-soil-near-a-pb-zn-smelter-in-feng-county-china
#8
Feng Shen, Renmei Liao, Amjad Ali, Amanullah Mahar, Di Guo, Ronghua Li, Sun Xining, Mukesh Kumar Awasthi, Quan Wang, Zengqiang Zhang
A large scale survey and a small scale continuous monitoring was conducted to evaluate the impact of Pb/Zn smelting on soil heavy metals (HMs) accumulation and potential ecological risk in Feng County, Shaanxi province of China. Soil parameters including pH, texture, CEC, spatial and temporal distribution of HMs (Cd, Cu, Ni, Pb and Zn), and BCR fractionation were monitored accordingly. The results showed the topsoil in the proximity of smelter, especially the smelter area and county seat, were highly polluted by HMs in contrast to the river basins...
February 1, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28143941/a-novel-molecular-assay-using-hybridisation-probes-and-melt-curve-analysis-for-calr-exon-9-mutation-detection-in-myeloproliferative-neoplasms
#9
Thomas Keaney, Louise O'Connor, Janusz Krawczyk, Moutaz A Abdelrahman, Amjad H Hayat, Margaret Murray, Michael O'Dwyer, Melanie Percy, Stehpen Langabeer, Karl Haslam, Barry Glynn, Ciara Mullen, Evelyn Keady, Sinéad Lahiff, Terry J Smith
AIMS: Somatic insertions/deletions in exon 9 of the calreticulin gene have been identified in patients with essential thrombocythemia and primary myelofibrosis. Over 55 mutations have been discovered, 80% of which consist of either type 1 52-bp deletion or type 2 5-bp insertion. Other mutations (types 3-5) in conjunction with types 1 and 2 account for >87% of identified mutations. The aim of this study was development of a rapid PCR-based assay using LightCycler Hybridisation Probes for the detection of type 1-5 CALR mutations...
January 31, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28138181/patients-knowledge-on-rheumatoid-arthritis-a-study-at-a-tertiary-care-hospital
#10
Zarghoona Khalil, Babur Salim, Amjad Nasim, Sakina Malik
OBJECTIVE: To determine the level of disease awareness among patients of rheumatoid arthritis. METHODS: The cross-sectional study was conducted at the Fauji Foundation Hospital, Rawalpindi, Pakistan, from January to June 2015, and comprised patients with rheumatoid arthritis. A self-made questionnaire was used which was translated in Urdu. The questionnaire had three sets of questions. The first set gathered information on the gender, age, level of education and the duration of the disease of the patient...
February 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28135667/phytoextraction-of-toxic-trace-elements-by-sorghum-bicolor-inoculated-with-streptomyces-pactum-act12-in-contaminated-soils
#11
Amjad Ali, Di Guo, Amanullah Mahar, Ping Wang, Fang Ma, Feng Shen, Ronghua Li, Zengqiang Zhang
The increasing industrial, mining and agricultural activities have intensified the release of potential toxic trace elements (PTEs), which are of great concern to human health and environment. The alarming increase in PTEs concentration, stress the need for biotechnological remediation approaches. In order to assist phytoextraction of PTEs, different combinations of Streptomyces pactum (Act12) with biochar were applied to mining and industrial polluted soils of Shaanxi and Hunan Provinces of China, respectively...
January 27, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28133584/preservation-of-the-myofascial-cuff-during-posterior-fossa-surgery-to-reduce-the-rate-of-pseudomeningocele-formation-and-cerebrospinal-fluid-leak-a-technical-note
#12
Daniel R Felbaum, Kyle Mueller, Amjad Anaizi, Robert B Mason, Walter C Jean, Jean M Voyadzis
INTRODUCTION:  Suboccipital craniotomy is a workhorse neurosurgical operation for approaching the posterior fossa but carries a high risk of pseudomeningocele and cerebrospinal fluid (CSF) leak. We describe our experience with a simple T-shaped fascial opening that preserves the occipital myofascial cuff as compared to traditional methods to reduce this risk. METHODS:  A single institution, retrospective review of prospectively collected database was performed of patients that underwent a suboccipital craniectomy or craniotomy...
December 28, 2016: Curēus
https://www.readbyqxmd.com/read/28120725/bile-salt-stabilized-vesicles-bilosomes-a-novel-nano-pharmaceutical-design-for-oral-delivery-of-proteins-and-peptides
#13
Javed Ahmad, Madhur Singhal, Saima Amin, Md Rizwanullah, Sohail Akhter, Mohammad Amjad Kamal, Nafis Haider, Patrick Midoux, Chantal Pichon
With the advent of novel vesicular drug delivery systems especially bilosomes, for large molecular weight proteins and peptides, their oral administration seems a viable approach. These nano-vesicles have shown promising results for the effective delivery of insulin and other therapeutics, perhaps due to their structural composition. The present review has elaborated the biopharmaceutical challenges for the oral delivery of therapeutic proteins and peptides as well as presented a novel approach to deliver the essential macromolecules through oral route as bilosomes...
January 24, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28112479/a-novel-stent-inflation-protocol-improves-long-term-outcomes-compared-with-rapid-inflation-deflation-deployment-method
#14
Srikanth Vallurupalli, Srikanth Kasula, Shiv Kumar Agarwal, Naga Venkata K Pothineni, Amjad Abualsuod, Abdul Hakeem, Zubair Ahmed, Barry F Uretsky
BACKGROUND: High-pressure inflation for coronary stent deployment is universally performed. However, the duration of inflation is variable and does not take into account differences in lesion compliance. We developed a standardized "pressure optimization protocol" (POP) using inflation pressure stability rather than an arbitrary inflation time or angiographic balloon appearance for stent deployment. Whether this approach improves long-term outcomes is unknown. METHODS AND RESULTS: 792 patients who underwent PCI using either rapid inflation/deflation (n = 376) or POP (n = 416) between January 2009 and March 2014 were included...
January 23, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28107934/tuning-sensitivity-of-a-simple-hydrazone-for-selective-fluorescent-turn-on-chemo-sensing-of-al-3-and-its-application-in-living-cells-imaging
#15
Faiz-Ur Rahman, Amjad Ali, Saira Khan Khalil, Rong Guo, Peng Zhang, Hui Wang, Zhan-Ting Li, Dan-Wei Zhang
Salicylaldehyde based hydrazones 2-((2-methyl-2-(pyridin-2-yl)hydrazono)methyl)phenol (SMPH), 4-methyl-2-((2-methyl-2-(pyridin-2-yl)hydrazono)methyl)phenol (MSMPH) and 4-fluoro-2-((2-methyl-2-(pyridin-2-yl)hydrazono)methyl)phenol (FSMPH) were prepared and structurally characterized. These hydrazones exhibited fluorescence "turn on" response toward Al(3+) in dimethyl formamide/water (DMF/H2O) (1: 1) mixture. SMPH showed enhanced emission (70 folds) as compared to MSMPH (46 folds) and FSMPH (28 folds) upon the addition of 3 equivalents of Al(3+)...
March 1, 2017: Talanta
https://www.readbyqxmd.com/read/28105288/discovery-of-spirocyclic-aldosterone-synthase-inhibitors-as-potential-treatments-for-resistant-hypertension
#16
Whitney L Petrilli, Scott B Hoyt, Clare London, Daniel McMasters, Andreas Verras, Mary Struthers, Doris Cully, Thomas Wisniewski, Ning Ren, Charlene Bopp, Andrea Sok, Qing Chen, Ying Li, Elaine Tung, Wei Tang, Gino Salituro, Ian Knemeyer, Bindhu Karanam, Joseph Clemas, Gaochao Zhou, Jack Gibson, Carrie Ann Shipley, Douglas J MacNeil, Ruth Duffy, James R Tata, Feroze Ujjainwalla, Amjad Ali, Yusheng Xiong
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, and lead-like physical and pharmacokinetic properties.
January 12, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28103802/proteomics-informed-by-transcriptomics-for-characterising-active-transposable-elements-and-genome-annotation-in-aedes-aegypti
#17
Kevin Maringer, Amjad Yousuf, Kate J Heesom, Jun Fan, David Lee, Ana Fernandez-Sesma, Conrad Bessant, David A Matthews, Andrew D Davidson
BACKGROUND: Aedes aegypti is a vector for the (re-)emerging human pathogens dengue, chikungunya, yellow fever and Zika viruses. Almost half of the Ae. aegypti genome is comprised of transposable elements (TEs). Transposons have been linked to diverse cellular processes, including the establishment of viral persistence in insects, an essential step in the transmission of vector-borne viruses. However, up until now it has not been possible to study the overall proteome derived from an organism's mobile genetic elements, partly due to the highly divergent nature of TEs...
January 19, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28103510/exo-organoplasty-interventions-a-brief-review-of-past-present-and-future-directions-for-advance-heart-failure-management
#18
REVIEW
Waqas Nawaz, Farhan Ullah Khan, Muhammad Zahid Khan, Wang Gang, Mengqi Yang, Xiaoqian Liao, Li Zhang, Awais Ullah Ihsan, Amjad Khan, Lei Han, Xiaohui Zhou
Heart failure (HF) is a debilitating disease in which abnormal function of the heart leads to imbalance of blood demand to tissues and organs. The pathogenesis of HF is very complex and various factors can contribute including myocardial infarction, ischemia, hypertension and genetic cardiomyopathies. HF is the leading cause of death and its prevalence is expected to increase in parallel with the population age. Different kind of therapeutic approaches including lifestyle modification, medication and pacemakers are used for HF patients in NYHA I-III functional class...
January 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28093996/challenges-related-to-glycemic-control-in-type-2-diabetes-mellitus-patients
#19
Masoumeh Kheirandish, Hamidreza Mahboobi, Maryam Yazdanparast, Mohammad Amjad Kamal
Diabetes mellitus (DM) is a chronic disease with long-term complications. Glycemic control is an important part in management of DM. The first line in treatment of type 2 DM (T2DM) is diet and life style change. Metformin is the first choice of medication in T2DM patients. Sulfonylureas have high risk of hypoglycemia. Glinides are associated with lower risk of hypoglycemia in comparison to sulfonylureas. Also α-glucosidase inhibitors decrease the polysacarides digestion in small intestine and less effective in comparison to metformin and sulfonylureas in lowering hemoglobin A1c (HbA1c)...
January 15, 2017: Current Drug Metabolism
https://www.readbyqxmd.com/read/28093994/viral-infection-and-obesity-current-status-and-future-prospective
#20
Sayed Sartaj Sohrab, Mohammad Amjad Kamal, Richard L Atkinson, Maha M Alawi, Esam I Azhar
The association of pathogenic viruses with obesity has now been well-known in both human and animals. Globally, human obesity has become a serious problem leading to the emergence of multiple life-threatening diseases. Adenoviruses contribute a significant role in the induction of obesity by affecting various pathways. Due to impaired immunity, obese individuals are more prone to nosocomial infections leading to complications of obesity. In contrast, several other important factors contributing to human obesity are known...
January 16, 2017: Current Drug Metabolism
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