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https://www.readbyqxmd.com/read/29351582/sco2-mutations-cause-early-onset-axonal-charcot-marie-tooth-disease-associated-with-cellular-copper-deficiency
#1
Adriana P Rebelo, Dimah Saade, Claudia P Pereira, Amjad Farooq, Tyler C Huff, Lisa Abreu, Carlos T Moraes, Diana Mnatsakanova, Kathy Mathews, Hua Yang, Eric A Schon, Stephan Zuchner, Michael E Shy
Recessive mutations in the mitochondrial copper-binding protein SCO2, cytochrome c oxidase (COX) assembly protein, have been reported in several cases with fatal infantile cardioencephalomyopathy with COX deficiency. Significantly expanding the known phenotypic spectrum, we identified compound heterozygous variants in SCO2 in two unrelated patients with axonal polyneuropathy, also known as Charcot-Marie-Tooth disease type 4. Different from previously described cases, our patients developed predominantly motor neuropathy, they survived infancy, and they have not yet developed the cardiomyopathy that causes death in early infancy in reported patients...
January 16, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29344999/the-newer-classifications-of-the-chiari-malformations-with-clarifications-an-anatomical-review
#2
Fatima Azahraa Haddad, Ibraheem Qaisi, Nagham Joudeh, Hamada Dajani, Fareed Jumah, Amjad Elmashala, Nimer Adeeb, Joshua J Chern, R Shane Tubbs
In 1891 Hans Chiari described a group of congenital hindbrain anomalies, which were eventually named after him. He classified these malformations into three types (Chiari malformations I, II, and III), and four years later added the Chiari IV malformation. However, numerous reports across the literature do not seem to fit Chiari's original descriptions of these malformations, so researchers have been encouraged to propose new classifications to encompass these variants (e.g., Chiari 0, Chiari1.5, and Chiari 3...
January 18, 2018: Clinical Anatomy
https://www.readbyqxmd.com/read/29325865/emerging-discrepancies-in-conventional-and-molecular-epidemiology-of-methicillin-resistant-staph-aureus-isolated-from-bovine-milk
#3
Amjad Islam Aqib, Muhammad Ijaz, Shahid Hussain Farooqi, Rais Ahmed, Muhammad Shoaib, Muhammad Muddassir Ali, Khalid Mehmood, Hui Zhang
Methicillin resistant Staph aureus (MRSA) is an emerging public health concern from dairy milk, and its diagnosis by phenotypic methodology is experiencing higher discrepancies. The present study was planned to estimate discrepancies in phenotypic identification of MRSA and MSSA (Methicillin sensitive Staph aureus) in relation to mecA, and prevalent risk factors from various localities. In-vitro oxacilline antibiotic disks were used for phenotypic identification of MRSA, whereas mecA gene was used as MRSA marker in Staph aureus by PCR...
January 8, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29324582/quality-measures-in-acute-kidney-injury
#4
Amjad Mehboob, Robert Zimmerman, Stuart Abramson, Mark G Parker
PURPOSE OF REVIEW: Quality measure assessment and reporting is evolving in end-stage renal disease care and is inchoate in ambulatory nephrology clinic care. Acute kidney injury (AKI) quality measures have not received sufficient attention, yet deserve consideration in view of the substantial proportion of effort nephrology providers devote to AKI care. RECENT FINDINGS: Accumulating literature permits consideration of timing of nephrology consultation, follow-up after AKI hospitalization, early detection, medication dosing, hospital readmissions and length of stay, cost, and mortality as putative AKI quality measures...
January 10, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29321947/portal-vein-thrombosis-due-to-an-increase-in-dose-of-testosterone-in-a-young-man-with-klinefelter-syndrome
#5
Waseem Amjad, Salma Khatoon, Twara Tarasaria, Gulru Sharifova
Klinefelter syndrome (KS) is associated with increased incidence of thrombotic events. Hypofibrinolysis is associated with increased risk of thromboembolism. Although testosterone replacement therapy (TRT) inhibits the hypofibrinolysis, it can still cause thrombosis paradoxically due to increased dose and duration of use. Herein, we present a case of a young male diagnosed with KS who was taking testosterone. The dose was increased to boost the energy levels, and the patient presented with abdominal pain. Computed tomography (CT) of the abdomen showed extensive portal vein thrombosis...
November 6, 2017: Curēus
https://www.readbyqxmd.com/read/29319147/factors-associated-with-low-birthweight-in-term-pregnancies-a-matched-case-control-study-from-rural-pakistan
#6
Muhammad A Habib, Camille R Greenow, Shabina Ariff, Sajid Soofi, Abid Hussain, Qamar Junejo, Amjad Hussain, Fariha Shaheen, Kirsten I Black
Low birthweight (LBW) remains a significant public health problem in Pakistan and further understanding of factors associated with LBW is required. We conducted a hospital-based matched case control study to identify risk factors associated with LBW in a rural district of Pakistan. We found that illiteracy (AOR: 2.68; 95% CI: 1.59 - 4.38), nulliparity (AOR: 1.82; 95% CI: 1.26-2.44), having a previous miscarriage/abortion (AOR: 1.22; 95% CI: 1.06-2.35), having < 2 antenatal care (ANC) visits during last pregnancy (AOR: 2...
January 2, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29317951/parafunctional-behaviors-and-its-effect-on-dental-bridges
#7
REVIEW
Amal Alharby, Hanan Alzayer, Ahmed Almahlawi, Yazeed Alrashidi, Samaa Azhar, Maan Sheikho, Anas Alandijani, Amjad Aljohani, Manal Obied
Parafunctional behaviors, especially bruxism, are not uncommon among patient visiting dentists' clinics daily and they constitute a major dental issue for almost all dentists. Many researchers have focused on the definition, pathophysiology, and treatment of these behaviors. These parafunctional behaviors have a considerable negative impact on teeth and dental prothesis. In this review, we focused on the impact of parafunctional behaviors on dental bridges. We summarized the definitions, epidemiology, pathophysiology, and consequences of parafunctional behaviors...
February 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29306724/first-molecular-evidence-of-equine-granulocytic-anaplasmosis-in-pakistan
#8
Sehrish Saleem, Muhammad Ijaz, Shahid Hussain Farooqi, Muhammad Imran Rashid, Amjad Khan, Awais Masud, Amjad Islam Aqib, Kashif Hussain, Khalid Mehmood, Hui Zhang
Anaplasma phagocytophilum (A. phagocytophilum) is an obligate intracellular bacterium that causes equine granulocytic anaplasmosis (EGA) disease in equines. This pathogen has zoonotic potential, which makes it very important to be detected and controlled as early as possible. This study was aimed to assess the molecular prevalence, associated risk factors of EGA along with its effects on various hematological parameters. This study revealed an overall 10.67% prevalence in equine. Horses showed highest prevalence followed by mules and donkeys presenting 11...
January 4, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29302940/determinants-and-outcome-of-decision-making-among-patients-with-severe-aortic-stenosis
#9
Amjad I Hussain, Andreas Auensen, Cathrine Brunborg, Svend Aakhus, Arnt Fiane, Kjell I Pettersen, Lars Gullestad
BACKGROUND: Aortic valve replacement (AVR) improves survival and quality of life in patients with severe aortic stenosis (AS), but despite clear indications for surgical treatment a significant proportion of patients do not undergo AVR. The study aim was to identify clinical variables associated with the decision to perform AVR, and to assess the prognostic effect of surgery versus medical treatment in patients with severe AS adjusted for significant confounders and effect modifiers. METHODS: A prospective observational study of consenting patients aged >18 years who were under consideration for AVR at the authors' tertiary teaching hospital was conducted...
July 2017: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/29301332/arsenic-uptake-toxicity-detoxification-and-speciation-in-plants-physiological-biochemical-and-molecular-aspects
#10
REVIEW
Ghulam Abbas, Behzad Murtaza, Irshad Bibi, Muhammad Shahid, Nabeel Khan Niazi, Muhammad Imran Khan, Muhammad Amjad, Munawar Hussain
Environmental contamination with arsenic (As) is a global environmental, agricultural and health issue due to the highly toxic and carcinogenic nature of As. Exposure of plants to As, even at very low concentration, can cause many morphological, physiological, and biochemical changes. The recent research on As in the soil-plant system indicates that As toxicity to plants varies with its speciation in plants (e.g., arsenite, As(III); arsenate, As(V)), with the type of plant species, and with other soil factors controlling As accumulation in plants...
January 2, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29291095/the-interaction-of-fatigue-cracks-with-a-residual-stress-field-using-thermoelastic-stress-analysis-and-synchrotron-x-ray-diffraction-experiments
#11
Khurram Amjad, David Asquith, Eann A Patterson, Christopher M Sebastian, Wei-Chung Wang
This article presents an experimental study on the fatigue behaviour of cracks emanating from cold-expanded holes utilizing thermoelastic stress analysis (TSA) and synchrotron X-ray diffraction (SXRD) techniques with the aim of resolving the long-standing ambiguity in the literature regarding potential relaxation, or modification, of beneficial compressive residual stresses as a result of fatigue crack propagation. The crack growth rates are found to be substantially lower as the crack tip moved through the residual stress zone induced by cold expansion...
November 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29290294/investigating-the-epidemiology-of-ei-epidemic-spread-in-the-province-of-khyber-pakhtunkhwa-pakistan-in-2015-16
#12
Amjad Khan, Muhammad Hassan Mushtaq, Mansur Ud Din Ahmad, Jawad Nazir, Zahida Fatima, Asghar Khan, Shahid Hussain Farooqi
EI in non-vaccinated population causes disruption and economic losses. To identify the risk factors associated with the EI epidemics in equids in Pakistan, a 1:1 matched case control study was conducted during 2015-2016. Including a total of 197 laboratory confirmed cases and negative controls, matched on the basis of geography, time of sampling, specie and age. A piloted questionnaire was used to collect data regarding risk factors associated with the occurrence of EI in face to face interviews. Conditional logistic regression was performed to analyze the data...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29279680/smile-esthetics-impact-of-variations-in-the-vertical-and-horizontal-dimensions-of-the-maxillary-lateral-incisors
#13
Amjad Al Taki, Ahmad Mohammad Hamdan, Ziad Mustafa, Mawada Hassan, Sami Abu-Alhuda
Objective: The purpose of this study was to determine the perception of trained dental professionals and laypersons toward the esthetic impact of variations in the vertical position, width, and gingival height of the maxillary lateral incisor. Materials and Methods: The present study analyzed the perspective of smile photographs by dental professionals such as "fifty orthodontics and fifty general dental practitioners (GDPs)" as well as fifty laypersons, consisting of an equal number of male and female participants...
October 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/29278921/management-of-hyperuricemia-through-dietary-polyphenols-as-a-natural-medicament-a-comprehensive-review
#14
Arshad Mehmood, Lei Zhao, Chengtao Wang, Muhammad Nadeem, Ali Raza, Nawazish Ali, Amjad Abbas Shah
Hyperuricemia, a condition due to high serum uric acid level and is notorious to health. It is considered to be a potent risk factor for gout and dramatically associated in the development of many chronic diseases such as malignant tumor, cardiovascular disorders and renal failure. Modern innovative medicinal and therapeutic interventions are underlying these days to combat hyperuricemia. Previously reported studies revealed the significant impact of dietary polyphenols (e.g. anthocyanins, phenolic acids, flavonoids etc...
December 26, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/29278015/an-overview-on-the-current-status-of-cancer-nanomedicines
#15
Nasimudeen R Jabir, Khalid Anwar, Chelapram K Firoz, Mohammad Oves, Mohammad Amjad Kamal, Shams Tabrez
Cancer remains a significant cause of morbidity and mortality across the globe. A recent report suggests around 14.1 million new cases and 8.2 million cancer-related deaths, which are expected to reach 21.7 million and 13 million by 2030 worldwide, respectively. Because of highly complex mechanisms of cancer progression, it is important to explore and develop new innovative technologies which are more efficient compared with presently available treatment options. Currently, chemotherapy, radiation, and surgery are the most commonly used cancer treatment methods...
December 26, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/29274990/physico-chemical-forms-of-copper-in-water-and-sediments-of-lake-pontchartrain-basin-usa
#16
Zengqiang Zhang, Jim J Wang, Amjad Ali, R D DeLaune
In this study, one of the largest estuaries in the Gulf Coast of USA was investigated for Cu forms and fractionations. Both the water and sediment samples in subsegments of the Lake Pontchartrain basin were collected and Cu forms in dissolved phase and sediment phase were analyzed. The BCR sequential extraction procedure was used to extract Cu in exchangeable, reducible, oxidizable and residual fractions in sediments. The results showed that the residual fraction of Cu was a major contributor in Tangipahoa River and I-10 Bridge sediments, while the residual and oxidizable fractions in the case of oil refinery sediments...
December 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/29258510/comparison-of-machine-learning-techniques-to-predict-all-cause-mortality-using-fitness-data-the-henry-ford-exercise-testing-fit-project
#17
Sherif Sakr, Radwa Elshawi, Amjad M Ahmed, Waqas T Qureshi, Clinton A Brawner, Steven J Keteyian, Michael J Blaha, Mouaz H Al-Mallah
BACKGROUND: Prior studies have demonstrated that cardiorespiratory fitness (CRF) is a strong marker of cardiovascular health. Machine learning (ML) can enhance the prediction of outcomes through classification techniques that classify the data into predetermined categories. The aim of this study is to present an evaluation and comparison of how machine learning techniques can be applied on medical records of cardiorespiratory fitness and how the various techniques differ in terms of capabilities of predicting medical outcomes (e...
December 19, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/29248538/enzyme-targeting-strategies-for-prevention-and-treatment-of-cancer-implications-for-cancer-therapy
#18
REVIEW
Mohammad Hassan Baig, Mohd Adil, Rosina Khan, Surendar Dhadi, Khurshid Ahmad, Gulam Rabbani, Tufail Bashir, Mohammad Azhar Imran, Fohad Mabood Husain, Eun Ju Lee, Mohammad Amjad Kamal, Inho Choi
Extensive growth of cancer in humans is a major cause of death. Numerous studies are being conducted to improve the early diagnosis, prevention, and treatment of cancer. Recent technological advancements in medical science and research indicate molecular target therapy holds much promise in cancer treatment. In the past, therapeutic and diagnostic targeting of non-glycolytic and glycolytic enzymes in cancer have been successful, and discoveries of biomarker enzymes in cancer hold promise for therapeutic treatments...
December 14, 2017: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29245030/osmotin-a-plant-defense-tool-against-biotic-and-abiotic-stresses
#19
REVIEW
Hakim, Abid Ullah, Amjad Hussain, Muhammad Shaban, Aamir Hamid Khan, Muna Alariqi, Summia Gul, Zhang Jun, Sun Lin, Jianying Li, Shuangxia Jin, Muhammad Farooq Hussain Munis
Plants are prone to a number of pathogens and abiotic stresses that cause various disorders. However, plants possess a defense mechanism to cope with these stresses. The osmotin protein belongs to the PR-5 family of Pathogenesis-related (PR) proteins, which are produced in response to diseases caused by various biotic and abiotic stresses. Osmotin uses a signal transduction pathway to inhibit the activity of defensive cell wall barriers and increases its own cytotoxic efficiency. However, in response to cytotoxic effects, this pathway stimulates a mitogen-activated protein kinase (MAPK) cascade that triggers changes in the cell wall and enables osmotin's entrance into the plasma membrane...
December 7, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29242506/micrornas-regulate-key-cell-survival-pathways-and-mediate-chemosensitivity-during-progression-of-diffuse-large-b-cell-lymphoma
#20
Suvi-Katri Leivonen, Katherine Icay, Kirsi Jäntti, Ilari Siren, Chengyu Liu, Amjad Alkodsi, Alejandra Cervera, Maja Ludvigsen, Stephen Jacques Hamilton-Dutoit, Francesco d'Amore, Marja-Liisa Karjalainen-Lindsberg, Jan Delabie, Harald Holte, Rainer Lehtonen, Sampsa Hautaniemi, Sirpa Leppä
Despite better therapeutic options and improved survival of diffuse large B-cell lymphoma (DLBCL), 30-40% of the patients experience relapse or have primary refractory disease with a dismal prognosis. To identify biological correlates for treatment resistance, we profiled microRNAs (miRNAs) of matched primary and relapsed DLBCL by next-generation sequencing. Altogether 492 miRNAs were expressed in the DLBCL samples. Thirteen miRNAs showed significant differential expression between primary and relapse specimen pairs...
December 15, 2017: Blood Cancer Journal
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