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https://www.readbyqxmd.com/read/28316988/bioengineered-plants-can-be-a-useful-source-of-omega-3-fatty-acids
#1
REVIEW
Waleed Amjad Khan, Hu Chun-Mei, Nadeem Khan, Amjad Iqbal, Shan-Wu Lyu, Farooq Shah
Omega-3 fatty acids have proven to be very essential for human health due to their multiple health benefits. These essential fatty acids (EFAs) need to be uptaken through diet because they are unable to be produced by the human body. These are important for skin and hair growth as well as for proper visual, neural, and reproductive functions of the body. These fatty acids are proven to be extremely vital for normal tissue development during pregnancy and infancy. Omega-3 fatty acids can be obtained mainly from two dietary sources: marine and plant oils...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28302233/an-unusual-case-of-caecal-volvulus-due-to-appendicitis-successfully-managed-by-caecopexy
#2
Samiullah Bhatti, Mahmood Ayyaz Khan, Waris Farooka, Usman Ismat Butt, Usman Ali Rehman, Awais Amjad Malik
Caecal volvulus is a rare cause of intestinal obstruction. Caecal volvulus precipitated by acute appendicitis is even rarer. We report an unusual case of caecal volvulus with acute appendicitis as a cause. A 55-year female presented in surgical emergency with 3 days history of abdominal pain, distension and absolute constipation; and 2 days history of vomiting. Her past surgical history was significant for hysterectomy 5 years back. On examination, abdomen was distended and bowel sounds exaggerated. X-ray abdomen erect showed a single large air fluid level in the right hemiabdomen...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28299298/family-stigma-associated-with-epilepsy-a-qualitative-study
#3
Reza Nabi Amjad, Alireza Nikbakht Nasrabadi, Elham Navab
Introduction: Harmful nature of epilepsy can affect the patient and their parent. Stigma, arising from it, affects the patient and their family. To relieve it understanding the experiences of the parent are useful. This study was aimed at understanding the experiences of parent of child with epilepsy in Iran. Methods: In this interpretative phenomenological study, 10 parents who took care of their child with epilepsy were participated. Data were collected through in-depth semi-structured interviews. After transcription, data were analyzed using Van Manen's method...
March 2017: Journal of Caring Sciences
https://www.readbyqxmd.com/read/28297302/implementation-of-quality-medical-physics-training-in-a-low-middle-income-country-sharing-experience-from-a-tertiary-care-jcia-accredited-university-hospital
#4
Ahmed Nadeem Abbasi, Wazir Muhammad, Amjad Hussain
No abstract text is available yet for this article.
November 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28294460/retinal-imaging-analysis-based-on-vessel-detection
#5
Arshad Jamal, Mohammed Hazim Alkawaz, Amjad Rehman, Tanzila Saba
With an increase in the advancement of digital imaging and computing power, computationally intelligent technologies are in high demand to be used in ophthalmology cure and treatment. In current research, Retina Image Analysis (RIA) is developed for optometrist at Eye Care Center in Management and Science University. This research aims to analyze the retina through vessel detection. The RIA assists in the analysis of the retinal images and specialists are served with various options like saving, processing and analyzing retinal images through its advanced interface layout...
March 13, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28294049/in-silico-analysis-of-amp-activated-protein-kinase-and-ligand-based-virtual-screening-for-identification-of-novel-ampk-activators
#6
Ammarah Ghaffar, Sidra Batool, Gohar Mushtaq, Muhammad Amjad Kamal
BACKGROUND: Adenosine-Monophosphate-Activated protein kinase (AMPK) is a conserved kinase that plays an important role in maintaining the homeostasis of cells. AMPK activation has a positive impact on treatment of diseases such as diabetes, obesity and cancer as well. This observation led to the development of AMPK activators. Certain naturally occurring compounds have also been known to activate AMPK. METHOD: In this study, we retrieved the AMPK activators that includes chemical drugs, xenobiotics and natural compounds and analyzed their interactions with AMPK via docking studies...
March 9, 2017: Current Computer-aided Drug Design
https://www.readbyqxmd.com/read/28292725/physiological-and-antioxidant-response-of-wheat-triticum-aestivum-seedlings-to-fluoroquinolone-antibiotics
#7
Luqman Riaz, Tariq Mahmood, Mark S Coyne, Azeem Khalid, Audil Rashid, Malik Tahir Hayat, Asim Gulzar, Muhammad Amjad
Combinations of antibiotics occur in terrestrial environments due to excessive prescription, consumption, and disposal and have adverse effects, including crop toxicity. We examined short-term (20-d) toxicity of the fluoroquinolone antibiotics ciprofloxacin, enrofloxacin, levofloxacin, and their mixture in a germination and a greenhouse sand culture study with wheat. We tested the hypothesis that oxidative stress plays a role in toxicity by examining stress products and antioxidants involved in detoxifying reactive oxygen species (ROS) during stress...
March 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28288924/global-expansion-of-chikungunya-virus-mapping-the-64-year-history
#8
REVIEW
Braira Wahid, Amjad Ali, Shazia Rafique, Muhammad Idrees
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that is emerging as a global threat because of its highly debilitating nature and unprecedented magnitude. The disease originated from Africa and then hit the entire globe causing large number of epidemics that infected millions of people in Asia, Indian subcontinent, Europe, Americas, and Pacific Islands. According to phylogenetic analysis, four different genotypes of CHIKV are: Asian, West African, East/Central/South African (ECSA), and Indian Ocean lineage (IOL)...
March 10, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28284233/retrospective-study-of-rare-cutaneous-malignant-adnexal-tumors-of-the-head-and-neck-in-a-tertiary-care-cancer-hospital-a-case-series
#9
Omer Waqas, Muhammad Faisal, Irfan Haider, Awais Amjad, Arif Jamshed, Raza Hussain
BACKGROUND: Adnexal tumors of the skin are a large and diverse group of benign and malignant neoplasms, which exhibit morphological differentiation toward one of the different types of adnexal epithelium present in normal skin and they pose a diagnostic challenge. The purpose of this study is to share our experience with these rare but aggressive tumors at a tertiary care cancer hospital in a developing country. A retrospective review of 11 patients diagnosed with rare adnexal tumors and their variants from January 2005 to December 2014, treated either surgically or non-surgically, was performed to describe the clinicopathological characteristics and outcome of the disease...
March 12, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28281779/molecular-analysis-of-twelve-pakistani-families-with-nonsyndromic-or-syndromic-hearing-loss
#10
Rongrong Wang, Shirui Han, Amjad Khan, Xue Zhang
AIM: To investigate the causative genetic mutations in 12 Pakistani families with nonsyndromic or syndromic hearing loss. METHODS: Mutations in the most common causative gene for hearing loss, GJB2, were evaluated by Sanger sequencing. Targeted next-generation sequencing or whole-exome sequencing was used to analyze the genomic DNA samples from 11 probands with hearing loss. Sanger sequencing was performed to verify all identified variants. RESULTS: We found pathogenic, or likely to be pathogenic, mutations in all 12 families, including six known mutations in GJB2, SLC26A4, LHFPL5, and USH2A and eight novel mutations in ESPN, MYO7A, LRTOMT, PCDH15, USH2A, or EPS8L2...
March 10, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28280650/polycystic-liver-disease-and-sarcoidosis-unusual-coexisting-etiologies-of-portal-hypertension
#11
Waseem Amjad, Sophia Jagroop, Rukma Parthvi
Both polycystic liver disease (PLD) and sarcoidosis can involve liver. Most of the time, liver disease in both conditions is asymptomatic, but they can rarely cause portal hypertension. Our aim is to report a case of a 51-year-old female with a history of adult dominant polycystic kidney disease (ADPKD) and sarcoidosis who presented with multiple episodes of hematemesis. An endoscopy showed grade 3 esophageal varices. A computed tomography (CT) scan of the abdomen showed ascites with polycystic liver, nodular contour, and calcified granuloma...
January 25, 2017: Curēus
https://www.readbyqxmd.com/read/28280111/usp7-deubiquitinase-controls-hiv-1-production-by-stabilizing-tat-protein
#12
Amjad Ali, Rameez Raja, Sabihur Rahman Farooqui, Shaista Ahmad, Akhil C Banerjea
Deubiquitinases (DUBs) are key regulators of complex cellular processes.  HIV-1 Tat is synthesized early after infection and is mainly responsible for enhancing viral production. Here, we report that one of the DUBs, USP7, stabilized HIV-1 Tat protein through its deubiquitination. Treatment with either general DUB inhibitor (PR-619) or USP7-specific inhibitor (P5091) resulted in Tat protein degradation. USP7-specific inhibitor reduced virus production in latently infected T-lymphocytic cell line J1.1, which produces large amounts of HIV-1 upon stimulation...
March 9, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28277824/polymer-based-drug-delivery-the-quest-for-local-targeting-of-inflamed-intestinal-mucosa
#13
M Junaid Dar, Hussain Ali, Amjad Khan, Gul Majid Khan
Colon specific drug delivery has found important applications in the wide array of diseases affecting the lower intestinal tract. Recent developments and advancements in the polymer based colonic delivery ensure targeted therapeutics with reduced systemic adverse effects. Latest progress in the understanding of polymer science has decorated a polymer based formulation with a number of special features, which may prove effective in the localized drug targeting at specific sites of the intestine. Upon oral administration, polymeric vehicles or polymer coated formulations serve to protect the drug from premature release and degradation in the upper gastrointestinal tract...
February 23, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28275517/percutaneous-nephrolithotomy-in-complete-supine-flank-free-position-in-comparison-to-prone-position-a-single-centre-experience
#14
Nadeem Sohail, Amjad Albodour, Khalid Mohammed Abdelrahman
OBJECTIVES: To assess the outcomes of performing percutaneous nephrolithotomy (PCNL) in a modified supine position, more feasible for surgeons, anaesthetists, and operating theatre staff, as well as for the patient himself, and evaluating it in comparison to the standard prone position. PATIENT AND METHODS: A retrospective, case-control study was conducted between January 2011 and December 2015. In all, 197 patient's records were reviewed. The initial 101 patients were operated upon in prone position...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28271267/prior-experience-in-laparoscopic-rectal-surgery-can-minimise-the-learning-curve-for-robotic-rectal-resections-a-cumulative-sum-analysis
#15
Manfred Odermatt, Jamil Ahmed, Sofoklis Panteleimonitis, Jim Khan, Amjad Parvaiz
BACKGROUND: The learning curve for robotic colorectal surgery is ill-defined. This study aimed to investigate the learning curve of experienced laparoscopic rectal surgeons when starting with robotic total mesorectal excision (TME) using cumulative sum (CUSUM) charts. METHODS: This retrospective case series analysed patients who underwent curative and elective laparoscopic or robotic TMEs for rectal cancer performed by two surgeons. The first consecutive robotic TME cases of each surgeon were 1:1 propensity score matched to their laparoscopic TME cases using age, body mass index, American Society of Anesthesiologists grade, T stage (AJCC) and tumour location height...
March 7, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28271089/total-knee-arthroplasty-in-severe-unstable-knee-case-report-and-literature-review
#16
Mohammad Naghi Tahmasebi, Gholamreza Ghorbani Amjad, Mohammad Hassan Kaseb, Kaveh Bashti
Multiplanar or global laxity in arthritic knee is rare, most of this patients have neuromuscular disorder (post poliomyelitis, spinal dystrophy) or history of knee trauma. Ligament insufficiency and severe bone loss is significant in this patient. The estimated prevalence for the concurrence of charcot marie-tooth (CMT) with myasthenia gravis (MG) suggests an extremely rare event. We have presented a 54-year-old female patient with CMT and MG complaining of progressive pain, swelling, and crepitation of the knee joints who had been undergone total knee arthroplasty (TKA) with rotating hinge prosthesis...
January 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28270852/effects-of-honey-on-oral-mucositis-among-pediatric-cancer-patients-undergoing-chemo-radiotherapy-treatment-at-king-abdulaziz-university-hospital-in-jeddah-kingdom-of-saudi-arabia
#17
Soad K Al Jaouni, Mohammad S Al Muhayawi, Abear Hussein, Iman Elfiki, Rajaa Al-Raddadi, Saad M Al Muhayawi, Saad Almasaudi, Mohammad Amjad Kamal, Steve Harakeh
One of the most common complications of cancer chemotherapy is oral mucositis. This study evaluates the therapeutic effects of honey with the focus on grade III and IV oral mucositis, reduction of bacterial and fungal infections, duration of episodes of oral mucositis, and body weight in pediatric leukemic patients undergoing chemo/radiotherapy. This is an open labeled randomized controlled study conducted at our hospital on 40 pediatric cancer patients undergoing chemo/radiotherapy. All the 40 patients included in this study experienced a sum total of 390 episodes of fever and neutropenia associated with oral mucositis...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28267473/cardiorespiratory-fitness-and-incident-heart-failure-the-henry-ford-exercise-testing-fit-project
#18
Daniel F Kupsky, Amjad M Ahmed, Sherif Sakr, Waqas T Qureshi, Clinton A Brawner, Michael J Blaha, Jonathan K Ehrman, Steven J Keteyian, Mouaz H Al-Mallah
BACKGROUND: Prior studies have demonstrated cardiorespiratory fitness (CRF) to be a strong marker of cardiovascular health. However, there are limited data investigating the association between CRF and risk of progression to heart failure (HF). The purpose of this study was to determine the relationship between CRF and incident HF. METHODS: We included 66,329 patients (53.8% men, mean age 55 years) free of HF who underwent exercise treadmill stress testing at Henry Ford Health Systems between 1991 and 2009...
March 2017: American Heart Journal
https://www.readbyqxmd.com/read/28265389/chronic-lead-malposition-diagnosis-and-management-discussion-of-two-cases-and-literature-review
#19
Ahmed Almomani, Amjad Abualsuod, Hakan Paydak, Wilburt Peer, Waddah Maskoun
Management of lead malposition is crucial to avoid complications and is carried out on case-by-case bases. The 12-lead ECG during pacing and chest X-ray are essential during initial workup and recommended for new patients to the device clinic. Echocardiography and CT scan are important to confirm the location and plan appropriate therapy.
March 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28264471/epigenetics-in-stroke-recovery
#20
REVIEW
Haifa Kassis, Amjad Shehadah, Michael Chopp, Zheng Gang Zhang
While the death rate from stroke has continually decreased due to interventions in the hyperacute stage of the disease, long-term disability and institutionalization have become common sequelae in the aftermath of stroke. Therefore, identification of new molecular pathways that could be targeted to improve neurological recovery among survivors of stroke is crucial. Epigenetic mechanisms such as post-translational modifications of histone proteins and microRNAs have recently emerged as key regulators of the enhanced plasticity observed during repair processes after stroke...
February 27, 2017: Genes
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