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Nitrite oxide hepatic

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https://www.readbyqxmd.com/read/27829805/effect-of-amlodipine-lisinopril-and-allopurinol-on-acetaminophen-induced-hepatotoxicity-in-rats
#1
Nesreen E M Mohammed, Basim A S Messiha, Ali A Abo-Saif
BACKGROUND: Exposure to chemotherapeutic agents such as acetaminophen may lead to serious liver injury. Calcium deregulation, angiotensin II production and xanthine oxidase activity are suggested to play mechanistic roles in such injury. OBJECTIVE: This study evaluates the possible protective effects of the calcium channel blocker amlodipine, the angiotensin converting enzyme inhibitor lisinopril, and the xanthine oxidase inhibitor allopurinol against experimental acetaminophen-induced hepatotoxicity, aiming to understand its underlying hepatotoxic mechanisms...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27821159/ceratonia-siliqua-pod-extract-ameliorates-schistosoma-mansoni-induced-liver-fibrosis-and-oxidative-stress
#2
Ebtesam M Al-Olayan, Manal F El-Khadragy, Reem A Alajmi, Mohamed S Othman, Amira A Bauomy, Shaimaa R Ibrahim, Ahmed E Abdel Moneim
BACKGROUND: Schistosomiasis is a prevalent parasitic disease found predominantly in tropical and sub-tropical areas of the developing world, with the second highest socioeconomic and public health burden despite strenuous control efforts. In the present study, we aimed to investigate the ameliorative effects of Ceratonia siliqua pod extract (CPE) on liver fibrosis and oxidative stress in mice infected with Schistosoma mansoni. METHODS: The schistosomal hepatopathologic mouse model was established by tail immersion with schistosomal cercaria...
November 8, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27820841/metformin-ameliorates-dysfunctional-traits-of-glibenclamide-and-glucose-induced-insulin-secretion-by-suppression-of-imposed-overactivity-of-the-islet-nitric-oxide-synthase-no-system
#3
Ingmar Lundquist, Israa Mohammed Al-Amily, Sandra Meidute Abaraviciene, Albert Salehi
Metformin lowers diabetic blood glucose primarily by reducing hepatic gluconeogenesis and increasing peripheral glucose uptake. However, possible effects by metformin on beta-cell function are incompletely understood. We speculated that metformin might positively influence insulin secretion through impacting the beta-cell nitric oxide synthase (NOS)-NO system, a negative modulator of glucose-stimulated insulin release. In short-time incubations with isolated murine islets either glibenclamide or high glucose augmented insulin release associated with increased NO production from both neural and inducible NOS...
2016: PloS One
https://www.readbyqxmd.com/read/27791173/prolactin-alters-blood-pressure-by-modulating-the-activity-of-endothelial-nitric-oxide-synthase
#4
Albert S Chang, Ruriko Grant, Hirofumi Tomita, Hyung-Suk Kim, Oliver Smithies, Masao Kakoki
Increased levels of a cleaved form of prolactin (molecular weight 16 kDa) have been associated with preeclampsia. To study the effects of prolactin on blood pressure (BP), we generated male mice with a single-copy transgene (Tg; inserted into the hypoxanthine-guanine phosphoribosyltransferase locus) that enables inducible hepatic production of prolactin and its cleavage product. The Tg is driven by the indole-3-carbinol (I3C)-inducible rat cytochrome P450 1A1 promoter. When the Tg mice were fed normal chow (NC), plasma prolactin concentrations were comparable to those in female WT mice in the last third of pregnancy, and BP was lower than in WT mice (∼95 mm Hg vs...
November 1, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27687454/dexmedetomidine-acts-as-an-oxidative-damage-prophylactic-in-rats-exposed-to-ionizing-radiation
#5
Dilek Kutanis, Engin Erturk, Ahmet Besir, Yucel Demirci, Selcuk Kayir, Ali Akdogan, Birgul Vanizor Kural, Zumrut Bahat, Emine Canyilmaz, Hanife Kara
STUDY OBJECTIVE: To investigate the effects of dexmedetomidine on oxidative injury caused by ionizing radiation. DESIGN: Randomized controlled experimental study. SETTING: Department of radiation oncology and research laboratory of an academic hospital. INTERVENTIONS: Twenty-eight rats were randomized to 4 groups (n=7 per group). Group S rats were administered physiologic serum; group SR rats were administered physiologic serum and 10 Gy external ionizing radiation...
November 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27670067/effects-of-nitrite-addition-to-igl-1-solution-on-rat-liver-preservation
#6
Amani Cherif-Sayadi, Kaouther Hadj Ayed-Tka, Mohamed Bejaoui, Neyla Ben Gdara, Mohamed Amine Zaouali, Hassen Ben Abdennebi
BACKGROUND The ability of nitrite to provide protection following ischemia/reperfusion (I/R) has been demonstrated, but its mechanism is still poorly understood. This study aimed to determine the optimal nitrite concentration to add into Institut Georges Lopez (IGL-1) storage solution and to assess its effect on antioxidant enzymes and autophagy. MATERIAL AND METHODS Livers from Sprague-Dawley rats were conserved in IGL-1 for 24 hours at 4°C or in IGL-1 enriched with nitrite at 50, 500 and 1,000 nM, respectively, before being perfused ex-vivo at 37 °C for 120 minutes...
2016: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://www.readbyqxmd.com/read/27638633/agmatine-protects-rat-liver-from-nicotine-induced-hepatic-damage-via-antioxidative-antiapoptotic-and-antifibrotic-pathways
#7
Nagla A El-Sherbeeny, Manar A Nader, Ghalia M Attia, Hayam Ateyya
Tobacco smoking with its various forms is a global problem with proved hazardous effects to human health. The present work was planned to study the defending role of agmatine (AGM) on hepatic oxidative stress and damage induced by nicotine in rats. Thirty-two rats divided into four groups were employed: control group, nicotine-only group, AGM group, and AGM-nicotine group. Measurements of serum hepatic biochemical markers, lipid profile, and vascular cell adhesion molecule-1 were done. In addition, malondialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) activity, and nitrate/nitrite (NOx) levels were estimated in the liver homogenates...
September 16, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27546300/inhibition-of-the-jak-stat-pathway-by-ruxolitinib-ameliorates-thioacetamide-induced-hepatotoxicity
#8
Mohamed E Shaker, Sara H Hazem, Sylvia A Ashamallah
In an attempt to explore the role of the JAK/STAT pathway in liver inflammation, we investigated the effect of intervening this pathway by ruxolitinib in thioacetamide (TAA)-induced hepatotoxicity. Ruxolitinib treatments were administered to male mice either before or after intoxication with TAA. The hepatic histopathological and serum biochemical assessment revealed that ruxolitinib pre-treatments dose-dependently reduced TAA-induced liver injury, caspase 3 cleavage and increase in number of hepatocytes positive for the pro-apoptotic Bax, as well as inflammatory cells positive for F4/80 and myeloperoxidase activity in the liver...
October 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27524256/native-prussian-carp-carassius-gibelio-health-status-biochemical-and-histological-responses-to-treated-wastewaters
#9
Natalija Topić Popović, Ivančica Strunjak-Perović, Josip Barišić, Slavko Kepec, Margita Jadan, Blanka Beer-Ljubić, Vesna Matijatko, Dušan Palić, Goran Klobučar, Sanja Babić, Jasenka Gajdoš Kljusurić, Rozelindra Čož-Rakovac
The aim of this study was to assess the impact of treated wastewaters on native wild Prussian carp inhabiting effluent-receiving waters (ERC) receiving municipal and sugar plant treated wastewaters, further downstream waters (DW), and a detached canal unaffected by the WWTP activities. To that end, general fish health status was determined, including plasma biochemical, haematological, oxidative stress and tissue histopathological indices, over three seasons. The greatest tissue alterations were in fall in ERC during sugar beet processing, as hypertrophy of gill epithelial and interlamellar cells, necrosis and lymphocytic infiltration, hyperplasia and hypertrophy of renal tubules, distention of hepatic sinusoids...
November 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27520857/combination-of-vildagliptin-and-pioglitazone-in-experimental-type-2-diabetes-in-male-rats
#10
Rowaida Refaat, Ahmed Sakr, Mona Salama, Ashgan El Sarha
Preclinical Research The majority of studies on vildagliptin and pioglitazone have focused on their combination in glycemic control. The aim of the present study was to investigate their effects in combination on (i) hyperglycemia-induced oxidative stress and inflammation and (ii) on organs involved in the pathophysiology of diabetes, pancreas, kidney and liver. Type 2 diabetes was induced using low-dose streptozotocin in male Wistar rats. Diabetic rats were treated for 4 weeks, with vildagliptin (10 mg/kg/day), pioglitazone (10 mg/kg/day) and their combination...
September 2016: Drug Development Research
https://www.readbyqxmd.com/read/27506743/imbalance-of-plasma-amino-acids-metabolites-and-lipids-in-patients-with-lysinuric-protein-intolerance-lpi
#11
Johanna Kurko, Maaria Tringham, Laura Tanner, Kirsti Näntö-Salonen, Mari Vähä-Mäkilä, Heli Nygren, Päivi Pöhö, Niina Lietzen, Ismo Mattila, Anu Olkku, Tuulia Hyötyläinen, Matej Orešič, Olli Simell, Harri Niinikoski, Juha Mykkänen
BACKGROUND: Lysinuric protein intolerance (LPI [MIM 222700]) is an aminoaciduria with defective transport of cationic amino acids in epithelial cells in the small intestine and proximal kidney tubules due to mutations in the SLC7A7 gene. LPI is characterized by protein malnutrition, failure to thrive and hyperammonemia. Many patients also suffer from combined hyperlipidemia and chronic kidney disease (CKD) with an unknown etiology. METHODS: Here, we studied the plasma metabolomes of the Finnish LPI patients (n=26) and healthy control individuals (n=19) using a targeted platform for analysis of amino acids as well as two analytical platforms with comprehensive coverage of molecular lipids and polar metabolites...
September 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/27488054/phytochemical-antioxidant-and-hepatoprotective-effects-of-alnus-nitida-bark-in-carbon-tetrachloride-challenged-sprague-dawley-rats
#12
Moniba Sajid, Muhammad Rashid Khan, Naseer Ali Shah, Sayed Afzal Shah, Hammad Ismail, Tahira Younis, Zartash Zahra
BACKGROUND: Alnus nitida (Spach) Endl. is traditionally used for inflammatory disorders. Diarylheptanoids constituents having diverse therapeutically importance including hepato-protective was reported in A. nitida. The aim of this study was to explore the antioxidant and hepato-protective profile of A. nitida stem bark's crude methanol extract (ANM). METHODS: Crude methanol extract of A. nitida stem bark and its derived fractions were assessed for phytochemical classes and in vitro antioxidant profiling by multidimensional assays...
2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27474679/attenuation-of-inflammation-by-marine-algae-turbinaria-ornata-in-cotton-pellet-induced-granuloma-mediated-by-fucoidan-like-sulphated-polysaccharide
#13
Ananthi Subash, Gayathri Veeraraghavan, Veeresh Kumar Sali, Meenakshi Bhardwaj, Hannah R Vasanthi
Turbinaria ornata, a commonly found marine brown algae along the Gulf of Mannar, Southeast coast of India was evaluated for its anti-inflammatory potential and the bioactive compound present in it was characterized. Cotton pellet induced granuloma model in rats was used to assess the anti-inflammatory potential of the aqueous extract of Turbinaria ornata (ATO) (30, 100 and 300mg/kg, p.o) which was compared with dexamethasone (0.1mg/kg, p.o) a standard anti-inflammatory agent. Granuloma weight, haematological parameters and plasma markers (LDH, GPT, and CRP) were estimated...
October 20, 2016: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27447720/prior-exercise-training-prevent-hyperglycemia-in-stz-mice-by-increasing-hepatic-glycogen-and-mitochondrial-function-on-skeletal-muscle
#14
Afonso Kopczynski de Carvalho, Sabrina da Silva, Edenir Serafini, Daniela Roxo de Souza, Hemelin Resende Farias, Gustavo de Bem Silveira, Paulo Cesar Lock da Silveira, Claudio Teodoro de Souza, Luis Valmor Portela, Alexandre Pastoris Muller
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. We investigated the effect of a prior thirty days voluntary exercise protocol on STZ-diabetic CF1 mice. Glycemia, and the liver and skeletal muscle glycogen, mitochondrial function and redox status were analyzed up to five days after STZ injection. Animals were engaged in the following groups: Sedentary vehicle (Sed Veh), Sedentary STZ (Sed STZ), Exercise Vehicle (Ex Veh) and Exercise STZ (Ex STZ). Exercise prevented fasting hyperglycemia in the Ex STZ group...
July 22, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/27418682/effect-of-nitrate-supplementation-on-hepatic-blood-flow-and-glucose-homeostasis-a-double-blind-placebo-controlled-randomized-control-trial
#15
Anthony I Shepherd, Daryl P Wilkerson, Jon Fulford, Paul G Winyard, Nigel Benjamin, Angela C Shore, Mark Gilchrist
Nitric oxide alters gastric blood flow, improves vascular function, and mediates glucose uptake within the intestines and skeletal muscle. Dietary nitrate, acting as a source of nitric oxide, appears to be a potential low-cost therapy that may help maintain glucose homeostasis. In a randomized, double-blind, placebo-controlled crossover study, 31 young and older adult participants had a standardized breakfast, supplemented with either nitrate-rich beetroot juice (11.91 mmol nitrate) or nitrate-depleted beetroot juice as placebo (0...
September 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27389247/evidence-of-oxidative-stress-in-brain-and-liver-of-young-rats-submitted-to-experimental-galactosemia
#16
Márcia B Castro, Bruna K Ferreira, José Henrique Cararo, Adália E Chipindo, Marina L Magenis, Monique Michels, Lucinéia G Danielski, Marcos R de Oliveira, Gustavo C Ferreira, Emilio L Streck, Fabricia Petronilho, Patrícia F Schuck
Galactosemia is a disorder of galactose metabolism, leading to the accumulation of this carbohydrate. Galactosemic patients present brain and liver damage. For evaluated oxidative stress, 30-day-old males Wistar rats were divided into two groups: galactose group, that received a single injection of this carbohydrate (5 μmol/g), and control group, that received saline 0.9 % in the same conditions. One, twelve or twenty-four hours after the administration, animals were euthanized and cerebral cortex, cerebellum, and liver were isolated...
July 7, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27357826/mcd-diet-induced-steatohepatitis-is-associated-with-alterations-in-asymmetric-dimethylarginine-adma-and-its-transporters
#17
Laura G Di Pasqua, Clarissa Berardo, Vittoria Rizzo, Plinio Richelmi, Anna Cleta Croce, Mariapia Vairetti, Andrea Ferrigno
Using an experimental model of NASH induced by a methionine-choline-deficient (MCD) diet, we investigated whether changes occur in serum and tissue levels of asymmetric dimethylarginine (ADMA). Male Wistar rats underwent NASH induced by 8-week feeding with an MCD diet. Serum and hepatic biopsies at 2, 4 and 8 weeks were taken, and serum enzymes, ADMA and nitrate/nitrite (NOx), were evaluated. Hepatic biopsies were used for mRNA and protein expression analysis of dimethylarginine dimethylaminohydrolase-1 (DDAH-1) and protein methyltransferases (PRMT-1), enzymes involved in ADMA metabolism and synthesis, respectively, and ADMA transporters (CAT-1, CAT-2A and CAT-2B)...
August 2016: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/27269004/effect-of-captopril-and-telmisartan-on-methotrexate-induced-hepatotoxicity-in-rats-impact-of-oxidative-stress-inflammation-and-apoptosis
#18
Mina T Kelleni, Salwa A Ibrahim, Aly M Abdelrahman
Methotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid drug whose efficacy is limited by its hepatotoxicity. The aim of this study was to investigate the possible protective role of captopril (100 mg/kg/day, p.o. for seven days), an angiotensin converting enzyme inhibitor, and telmisartan (10 mg/kg/day p.o. for seven days), an angiotensin II receptor blocker with peroxisome proliferative receptor gamma (PPARγ) agonism, in a model of MTX (single dose 20 mg/kg i.p. at the fifth day) induced hepatotoxicity in rats...
June 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27243218/immunometabolic-status-during-the-peripartum-period-is-enhanced-with-supplemental-zn-mn-and-cu-from-amino-acid-complexes-and-co-from-co-glucoheptonate
#19
Fernanda Batistel, Johan S Osorio, Annarita Ferrari, Erminio Trevisi, Michael T Socha, Juan J Loor
The peripartum (or transition) period is the most-critical phase in the productive life of lactating dairy cows and optimal supply of trace minerals through more bioavailable forms could minimize the negative effects associated with this phase. Twenty Holstein cows received a common prepartal diet and postpartal diet. Both diets were partially supplemented with an inorganic (INO) mix of Zn, Mn, and Cu to supply 35, 45, and 6 ppm, respectively, of the diet dry matter (DM). Cows were assigned to treatments in a randomized completed block design, receiving an daily oral bolus with INO or organic trace minerals (AAC) Zn, Mn, Cu, and Co to achieve 75, 65, 11, and 1 ppm supplemental, respectively, in the diet DM...
2016: PloS One
https://www.readbyqxmd.com/read/27191892/distinctive-expression-patterns-of-hypoxia-inducible-factor-1%C3%AE-and-endothelial-nitric-oxide-synthase-following-hypergravity-exposure
#20
Gun Yoon, Choong Sik Oh, Hyun-Soo Kim
This study was designed to examine the expression of hypoxia-inducible factor-1α (HIF-1α) and the level and activity of endothelial nitric oxide synthase (eNOS) in the hearts and livers of mice exposed to hypergravity. Hypergravity-induced hypoxia and the subsequent post-exposure reoxygenation significantly increased cardiac HIF-1α levels. Furthermore, the levels and activity of cardiac eNOS also showed significant increase immediately following hypergravity exposure and during the reoxygenation period. In contrast, the expression of phosphorylated Akt (p-Akt) and phosphorylated extracellular signal-regulated kinase (p-ERK) showed significant elevation only during the reoxygenation period...
June 7, 2016: Oncotarget
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