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https://www.readbyqxmd.com/read/28225950/diabetes-mellitus-and-the-skin
#1
Adriana Lucia Mendes, Helio Amante Miot, Vidal Haddad
Several dermatoses are routinely associated with diabetes mellitus, especially in patients with chronic disease. This relationship can be easily proven in some skin disorders, but it is not so clear in others. Dermatoses such necrobiosis lipoidica, granuloma annulare, acanthosis nigricans and others are discussed in this text, with an emphasis on proven link with the diabetes or not, disease identification and treatment strategy used to control those dermatoses and diabetes.
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28214312/update-treatment-of-necrobiosis-lipoidica
#2
REVIEW
Melanie Peckruhn, Jörg Tittelbach, Peter Elsner
Necrobiosis lipoidica (NL) is a rare granulomatous disease of hitherto unclear etiology frequently seen in patients with diabetes. Characterized by its potential for ulcerations, it often presents a serious burden for those affected. There are currently neither German nor European guidelines for the treatment of NL. At the same time, standard treatment with topical or intralesional corticosteroids does not always show satisfactory results. We therefore set out to evaluate whether the various treatment regimens published since 2000 have actually expanded the therapeutic armamentarium in a relevant manner...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28214306/update-therapie-der-necrobiosis-lipoidica
#3
REVIEW
Melanie Peckruhn, Jörg Tittelbach, Peter Elsner
Die Necrobiosis lipoidica ist eine seltene granulomatöse Erkrankung von bisher unzureichend geklärter Ätiologie. Häufig stellt die bei Diabetikern gehäuft zu beobachtende und zur Ulzeration neigende Dermatose eine starke Belastung für die Patienten dar. Bezüglich der Therapie existieren aktuell keine deutschen oder europäischen Leitlinien. Gleichzeitig lässt sich unter der aktuellen Standardtherapie, der lokalen oder intraläsionalen Anwendung von Glukokortikoiden, nicht immer ein zufriedenstellendes Ansprechen beobachten...
February 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28211041/a-granulomatous-conundrum-concurrent-necrobiosis-lipoidica-cutaneous-sarcoidosis-and-erythema-nodosum-in-a-nondiabetic-patient
#4
Nishant Valecha, Genevieve Bennett, Leona Yip
Necrobiosis lipoidica (NL) and cutaneous sarcoidosis are granulomatous disorders with a largely unknown aetiopathogenesis. Evidence of co-existing NL and sarcoidosis in the same patient may suggest a degree of overlap between these entities through shared granulomatous inflammatory pathways. Occasionally, one condition can mimic the other, making their distinction difficult. We report a novel case of a non-diabetic woman who presented with concurrent NL, cutaneous sarcoidosis and erythema nodosum. We discuss some of the complexities distinguishing these entities and propose that they may represent different stages of the same granulomatous process linked through yet unknown pathomechanisms...
February 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28094163/granulomatous-histiocytic-dermatitides
#5
Mark R Wick
Granulomas of the skin may be classified in several ways. They are either infectious or non-infectious in character, and they contain areas of necrobiosis or necrosis, or not. Responsible infectious agents may be mycobacterial, fungal, treponemal, or parasitic organisms, and each case of granulomatous dermatitis should be assessed histochemically for those microbes. In the non-infectious group, examples of necrobiotic or necrotizing granulomas include granuloma annulare; necrobiosis lipoidica; rheumatoid nodule; and lupus miliaris disseminates faciei...
December 14, 2016: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28007053/specific-skin-signs-as-a-cutaneous-marker-of-diabetes-mellitus-and-the-prediabetic-state-a-systematic-review
#6
Rewend Salman Bustan, Daanyaal Wasim, Knud Bonnet Yderstræde, Anette Bygum
INTRODUCTION: Diabetes mellitus and the prediabetic state are associated with a number of skin manifestations. This study is a systematic review of the following manifestations: acanthosis nigricans (AN), skin tags (ST), diabetic dermopathy (DD), rubeosis faciei (RF), pruritus (PR), granuloma annulare (GA), necrobiosis lipoidica (NL), scleroedema diabeticorum (SD) and bullosis diabeticorum (BD). These conditions possibly relate to underlying diabetogenic mechanisms. Our aim was to determine whether skin signs are feasible as cutaneous markers for the prediabetic or diabetic state...
January 2017: Danish Medical Journal
https://www.readbyqxmd.com/read/28000235/subcutaneous-dirofilariasis-a-masquerade-of-a-palisaded-granulomatous-dermatitis
#7
Kristen E Muller, Joseph D Schwartzman, Gregory D Seidel
Dirofilaria species are roundworms responsible for "heartworm" in canines. On occasion, humans are an accidental host, resulting in pulmonary (D. immitis) or extrapulmonary (D. repens) manifestations. Of the extrapulmonary sites of involvement, subcutaneous involvement is particularly common. We report a case of a 49 year-old female who presented with an erythematous nodule on her shin, which closely resembled necrobiosis lipoidica on histopathologic examination. On closer examination, there were foci of necrosis which harbored segments of the nematode, diagnostic of dirofiliarisis...
December 21, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27771664/necrobiosis-lipoidica
#8
Selim Dereci, Ozgur Pirgon
No abstract text is available yet for this article.
September 8, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27726872/-perforating-necrobiosis-lipoidica
#9
N Kluger, C Segretin, M-H Jegou
No abstract text is available yet for this article.
February 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27686584/necrobiosis-lipoidica
#10
Victoria Mitre, Connie Wang, Raegan Hunt
No abstract text is available yet for this article.
September 26, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27648379/dermoscopy-could-be-useful-in-differentiating-sarcoidosis-from-necrobiotic-granulomas-even-after-treatment-with-systemic-steroids
#11
Shahira Ramadan, Dalia Hossam, Marwah A Saleh
BACKGROUND: Diagnosing cutaneous sarcoidosis and necrobiotic granulomas is challenging. OBJECTIVE: Assessing the value of dermoscopy in differentiating cutaneous sarcoidosis from necrobiotic granulomas and evaluating whether their dermoscopic features will be altered after treatment. METHODS: Nineteen cutaneous sarcoidosis and 11 necrobiotic granuloma patients (2 necrobiosis lipoidica, 4 granuloma annulare and 5 rheumatoid nodule) were included in this study...
July 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27617606/an-atrophic-plaque-on-the-breast-six-years-after-breast-reconstruction-surgery
#12
Michele Khurana, Richard Torbeck, Young Kauh
Necrobiosis lipoidica (NL) is a cutaneous disease entity that typically manifests as atrophic yellow plaques with telangiectasias on the anterior tibial region. Although NL is commonly associated with diabetes mellitus, the role of trauma in disease development is less commonly emphasized. The relationship between NL and the Köbner phenomenon has been established, as a few cases of NL occurring in surgical scars have been reported in the literature. We report the first case of NL occurring in a mastectomy scar on the breast in a non-diabetic female, and explore the relationship between NL, diabetes mellitus, and trauma...
June 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27613297/dermoscopy-in-general-dermatology-a-practical-overview
#13
REVIEW
Enzo Errichetti, Giuseppe Stinco
Over the last few years, dermoscopy has been shown to be a useful tool in assisting the noninvasive diagnosis of various general dermatological disorders. In this article, we sought to provide an up-to-date practical overview on the use of dermoscopy in general dermatology by analysing the dermoscopic differential diagnosis of relatively common dermatological disorders grouped according to their clinical presentation, i.e. dermatoses presenting with erythematous-desquamative patches/plaques (plaque psoriasis, eczematous dermatitis, pityriasis rosea, mycosis fungoides and subacute cutaneous lupus erythematosus), papulosquamous/papulokeratotic dermatoses (lichen planus, pityriasis rosea, papulosquamous sarcoidosis, guttate psoriasis, pityriasis lichenoides chronica, classical pityriasis rubra pilaris, porokeratosis, lymphomatoid papulosis, papulosquamous chronic GVHD, parakeratosis variegata, Grover disease, Darier disease and BRAF-inhibitor-induced acantholytic dyskeratosis), facial inflammatory skin diseases (rosacea, seborrheic dermatitis, discoid lupus erythematosus, sarcoidosis, cutaneous leishmaniasis, lupus vulgaris, granuloma faciale and demodicidosis), acquired keratodermas (chronic hand eczema, palmar psoriasis, keratoderma due to mycosis fungoides, keratoderma resulting from pityriasis rubra pilaris, tinea manuum, palmar lichen planus and aquagenic palmar keratoderma), sclero-atrophic dermatoses (necrobiosis lipoidica, morphea and cutaneous lichen sclerosus), hypopigmented macular diseases (extragenital guttate lichen sclerosus, achromic pityriasis versicolor, guttate vitiligo, idiopathic guttate hypomelanosis, progressive macular hypomelanosis and postinflammatory hypopigmentations), hyperpigmented maculopapular diseases (pityriasis versicolor, lichen planus pigmentosus, Gougerot-Carteaud syndrome, Dowling-Degos disease, erythema ab igne, macular amyloidosis, lichen amyloidosus, friction melanosis, terra firma-forme dermatosis, urticaria pigmentosa and telangiectasia macularis eruptiva perstans), itchy papulonodular dermatoses (hypertrophic lichen planus, prurigo nodularis, nodular scabies and acquired perforating dermatosis), erythrodermas (due to psoriasis, atopic dermatitis, mycosis fungoides, pityriasis rubra pilaris and scabies), noninfectious balanitis (Zoon's plasma cell balanitis, psoriatic balanitis, seborrheic dermatitis and non-specific balanitis) and erythroplasia of Queyrat, inflammatory cicatricial alopecias (scalp discoid lupus erythematosus, lichen planopilaris, frontal fibrosing alopecia and folliculitis decalvans), nonscarring alopecias (alopecia areata, trichotillomania, androgenetic alopecia and telogen effluvium) and scaling disorders of the scalp (tinea capitis, scalp psoriasis, seborrheic dermatitis and pityriasis amiantacea)...
December 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/27212283/ultraviolet-a1-phototherapy-one-center-s-experience
#14
Sasi Kiran Attili, Robert S Dawe, Sally H Ibbotson
BACKGROUND: Ultraviolet A1(UVA1) phototherapy is increasingly being used in the treatment of morphea, atopic dermatitis, lupus and some other recalcitrant dermatoses. We present a retrospective review of our experience with this modality. AIM: To evaluate the treatment response rates for various dermatoses and adverse effects of UVA1 phototherapy. METHODS: We reviewed phototherapy notes along with electronic and/or paper case records for all patients treated with UVA1 phototherapy from October 1996 to December 2008...
January 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/27101431/risk-factors-for-necrobiosis-lipoidica-in-type-1-diabetes-mellitus
#15
E Hammer, E Lilienthal, S E Hofer, S Schulz, E Bollow, R W Holl
AIMS: To compare the clinical and metabolic characteristics of patients with Type 1 diabetes and necrobiosis lipoidica with those of patients with Type 1 diabetes who do not have necrobiosis lipoidica. A multicentre analysis was performed. METHODS: Clinical and laboratory data were obtained from 64 133 patients (aged 0-25 years) with Type 1 diabetes with and without necrobiosis lipoidica who were registered in the German/Austrian Diabetes Prospective Documentation Initiative registry...
January 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/27016885/dermatological-and-musculoskeletal-assessment-of-diabetic-foot-a-narrative-review
#16
REVIEW
Azam Arsanjani Shirazi, Morteza Nasiri, Leila Yazdanpanah
AIMS: Diabetic Foot Syndrome (DFS) is the most costly and devastating complication of diabetes mellitus (DM), which early effective assessment can reduce the severity of complications including ulceration and amputations. This study aimed to review dermatological and musculoskeletal assessment of diabetic foot. MATERIALS AND METHODS: In this review article, we searched for articles published between March 1, 1980 and July 28, 2015 in PubMed, Science Direct, Embase, Web of Science, and Scopus, for both English and non-English language articles with the following keywords: "Diabetic foot syndrome", "Ulceration", "Amputation", "Foot assessment", "Skin disorders" and "Musculoskeletal deformities"...
April 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27001349/sarcoidal-necrobiosis-lipoidica-in-a-nondiabetic-patient-usefulness-of-skin-ultrasound
#17
J García-Gavín, L Comba Pérez-Pérez, L Requena, X Wortsman
No abstract text is available yet for this article.
July 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/26975548/anti-tnf%C3%AE-treatment-for-recalcitrant-ulcerative-necrobiosis-lipoidica-diabeticorum-a-case-report-and-review-of-the-literature
#18
Dimitrios Basoulis, Kalliopi Fragiadaki, Nicholas Tentolouris, Petros P Sfikakis, Alexander Kokkinos
INTRODUCTION: Necrobiosis lipoidica diabeticorum (NLD) is a rare degenerative connective tissue disorder associated with diabetes mellitus, which usually presents with red papules or plaques with raised edges and occasional ulceration. Ulcerating NLD is notoriously difficult to treat. We present a young patient with ulcerative NLD who was successfully treated with the anti-TNFα agent infliximab. Case presentation is followed by a review of therapeutic TNFα blockade in NLD. CASE PRESENTATION: A 17-year old woman with type 1 diabetes since the age of 8, presented with a long-standing and extensively ulcerated and infected NLD lesion on her left shin...
April 2016: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/26972192/kofaktoren-und-komorbidit%C3%A3-ten-bei-necrobiosis-lipoidica-analyse-der-deutschen-drg-daten-von-2012
#19
Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt-Berge, Joachim Dissemond
HINTERGRUND: Die Necrobiosis lipoidica (NL) ist eine seltene, granulomatöse inflammatorische Erkrankung der Haut unklarer Pathophysiologie mit potentieller Assoziation zum Diabetes mellitus. Weitere relevante Kofaktoren und Komorbiditäten wurden bislang kontrovers diskutiert. PATIENTEN UND METHODIK: Differenziert ausgewertet wurden die Diagnosis-related-Groups (DRG)-Daten aller Patienten, die 2012 stationär in Deutschland behandelt und mit der Haupt- und Nebendiagnose NL kodiert wurden...
March 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/26972191/cofactors-and-comorbidities-of-necrobiosis-lipoidica-analysis-of-the-german-drg-data-from-2012
#20
Finja Jockenhöfer, Knut Kröger, Joachim Klode, Regina Renner, Cornelia Erfurt-Berge, Joachim Dissemond
BACKGROUND: Necrobiosis lipoidica (NL) is a rare granulomatous inflammatory skin disease of unknown pathophysiology. Its potential association with diabetes mellitus is well known. Other relevant cofactors and comorbidities are subject to controversial debate. PATIENTS AND METHODS: DRG (diagnosis-related groups) data of all inpatients with a coded primary or secondary diagnosis of NL treated at German hospitals in 2012 were evaluated. RESULTS: Data of 262 inpatient cases with the primary or secondary diagnosis of NL were analyzed...
March 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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