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estrogen in abnormal uterine bleeding

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https://www.readbyqxmd.com/read/27699734/-overview-of-endometrial-cancer
#1
Chia-Chun Li, Tsui-Hsia Feng
Endometrial cancer is the most common gynecological cancer and the sixth most common cancer among women in Taiwan. Risk factors for endometrial cancer include obesity, long-term estrogen replacement therapy, diabetes mellitus, hypertension, nulliparty, early age at menarche, late age at menopause, and tamoxifen therapy. Most women with endometrial cancer exhibit abnormal uterine bleeding. Endometrial cancer is often diagnosed at stage I. Surgery alone is the primary treatment for stage I endometrial cancer...
October 2016: Hu Li za Zhi the Journal of Nursing
https://www.readbyqxmd.com/read/27647770/efficacy-of-ormeloxifene-versus-oral-contraceptive-in-the-management-of-abnormal-uterine-bleeding-due-to-uterine-leiomyoma
#2
Alka Kriplani, Astha Srivastava, Vidushi Kulshrestha, Garima Kachhawa, Nutan Agarwal, Neerja Bhatla, Smriti Hari
AIM: To compare ormeloxifene with combined oral contraceptive (COC) in abnormal uterine bleeding (AUB) due to leiomyoma (AUB-L). METHODS: Fifty women with AUB-L were randomized after informed consent and institute ethics clearance. Group I (n = 25) was given ormeloxifene (a SERM i.e. selective estrogen receptor modulator) 60 mg twice per week and group II (n = 25) was given COC (ethinyl estradiol 30 μg with desogestrel 150 μg) on days 1-21 for 6 months...
September 20, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27447719/a-selective-estrogen-receptor-beta-agonist-for-the-treatment-of-hot-flushes-phase-2-clinical-trial
#3
Mary A Tagliaferri, Margit C Tagliaferri, Jennifer M Creasman, William D Koltun
OBJECTIVE: The aim of this study was to evaluate the safety, tolerability, and efficacy of a selective estrogen receptor beta (ERβ) agonist, Dr. Tagliaferri's Menopause Formula (MF102), to treat the symptoms of menopause. METHODS: An open-label trial of MF102 taken for 12 weeks by 30 postmenopausal women aged 40-65 years, who experienced a minimum of five moderate to severe hot flushes per day. The primary efficacy outcome was a change in the frequency of moderate to severe hot flushes from baseline to week 12...
September 2016: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
https://www.readbyqxmd.com/read/27319081/-adenomyosis-diagnostic-and-therapeutic-challenge
#4
REVIEW
Jaana Seikkula, Maarit Niinimäki, Pia Suvitie
In adenomyosis, endometrial glandular and stromal cells grow inside the myometrium, and form localized or diffusely expanding islets. Smooth muscle cells of the uterus surrounding the adenomyosis colonies become hypertrophic, which may lead to abnormal contractions of the uterine wall. Adenomyosis is an estrogen-dependent disease with abnormal uterine bleeding and dysmenorrhea as typical symptoms. The disease may even be asymptomate. The diagnosis is made by histologically or ultrasonic or MRI imaging. Adenomyosis can be treated with hormonal medications...
2016: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/27134949/a-randomised-controlled-trial-comparing-the-efficacy-and-side-effects-of-intravaginal-ring-nuvaring-%C3%A2-with-combined-oral-hormonal-preparation-in-dysfunctional-uterine-bleeding
#5
Sandhya Jain, Neelam B Vaid, Yam Narang, Amita Suneja, Kiran Guleria
INTRODUCTION: Combined Oral Contraceptive (COC) pills are being used in patients of abnormal uterine bleeding, especially adolescents and reproductive age women considering their need for contraception. It decreases the blood loss due to haemostatic effect of estrogen and also regularizes the cycle. Intravaginal route has been found to be effective and acceptable; Gastrointestinal absorption and hepatic first-pass metabolism is avoided and steady, uniform blood concentration is achieved...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27104158/ileo-uterine-fistula-in-a-degenerated-posterior-wall-fibroid-after-caesarean-section
#6
Ayman Shehata, Naglaa Hussein, Ahmed El Halwagy, Adel El Gergawy, Mohamed Khairallah
Uterine fibroids are benign tumors of the myometrium with a diverse range of manifestations. Fibroids can dramatically increase in size during pregnancy due to the increase in estrogen levels. After delivery, the fibroids usually shrink back to their pre-pregnancy size. Uterine myomas may have many complications, including abnormal uterine bleeding, infertility, pressure on nearby organs, degeneration, and malignant transformation. No previous reports have indicated that a fistula may develop between a uterine fibroid and the bowel loops, although previous studies have documented the occurrence of fistulas from the uterus to the bowel following myomectomy or uterine artery embolization performed to treat a myoma...
March 2016: Clinical and Experimental Reproductive Medicine
https://www.readbyqxmd.com/read/27067810/hemangiomas-of-the-uterine-cervix-association-with-abnormal-bleeding-and-pain-in-young-women-and-hormone-receptor-expression-report-of-four-cases-and-review-of-the-literature
#7
Aurelia Busca, Carlos Parra-Herran
Hemangiomas of the uterine cervix are rare with only about 55 cases reported in the literature. Increased awareness of this unusual cervical lesion can lead to early diagnosis and conservative therapeutic approaches. We present a series of four patients with cervical hemangioma with an extensive review of the existing literature on the subject. All four cervical hemangiomas were diagnosed incidentally in hysterectomy specimens performed for persistent menorrhagia or pain. The mean age at presentation was 34 years...
June 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/26917477/-research-of-gestrinone-related-abnormal-uterine-bleeding-and-the-intervention-in-the-treatment-a-multi-center-randomized-controlled-clinical-trial
#8
RANDOMIZED CONTROLLED TRIAL
H Duan, S Wang, M Hao, L Chen, J Tang, X Wang, Y Z Peng, S C Zhang, L R Cao, J J Yu
OBJECTIVE: To investigate the incidence, influencing factors and intervention of gestrinone-related abnormal uterine bleeding at different dosage of gestrinone in the clinical treatment. METHODS: This was a multicenter, randomized, control study of 195 Chinese women with endometriosis or adenomyosis from June 2011 to November 2013. The subjects were randomized into three groups with oral administration of gestrinone, 2.5 mg dose at one time; twice a week group: 67 cases with oral administration twice a week last three months; double dose first month group: 67 cases with oral administration triple times a week at first month, then twice a week for two months; three times a week group: 61 cases with oral administration three times a week last three months...
February 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/26696010/recurrent-venous-thromboembolism-and-abnormal-uterine-bleeding-with-anticoagulant-and-hormone-therapy-use
#9
Ida Martinelli, Anthonie W A Lensing, Saskia Middeldorp, Marcel Levi, Jan Beyer-Westendorf, Bonno van Bellen, Henri Bounameaux, Timothy A Brighton, Alexander T Cohen, Mila Trajanovic, Martin Gebel, Phuong Lam, Philip S Wells, Martin H Prins
Women receiving vitamin K antagonists (VKAs) require adequate contraception because of the potential for fetal complications. It is unknown whether the use of hormonal therapy, especially those containing estrogens, is associated with recurrent venous thromboembolism (VTE) during anticoagulation. Despite the absence of data, World Health Organization guidelines state that use of estrogen-containing contraceptives confers an "unacceptable health risk" during established anticoagulation for VTE. We compared the incidences of recurrent VTE and abnormal uterine bleeding with and without concomitant hormonal therapy in women aged <60 years who were receiving anticoagulation with rivaroxaban or enoxaparin/VKA for confirmed VTE...
March 17, 2016: Blood
https://www.readbyqxmd.com/read/26598450/the-diagnosis-of-polycystic-ovary-syndrome-in-adolescents
#10
REVIEW
Robert L Rosenfield
Consensus has recently been reached by international pediatric subspecialty societies that otherwise unexplained persistent hyperandrogenic anovulation using age- and stage-appropriate standards are appropriate diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescents. The purpose of this review is to summarize these recommendations and discuss their basis and implications. Anovulation is indicated by abnormal uterine bleeding, which exists when menstrual cycle length is outside the normal range or bleeding is excessive: cycles outside 19 to 90 days are always abnormal, and most are 21 to 45 days even during the first postmenarcheal year...
December 2015: Pediatrics
https://www.readbyqxmd.com/read/26569046/genital-cancers-in-women-uterine-cancer
#11
Michelle A Roett
There are two main types of uterine cancer. Endometrial carcinoma, the most commonly diagnosed genital cancer in women, accounts for most cases (more than 95%) and sarcoma comprises the remainder. Endometrial cancer primarily occurs in postmenopausal women. Risk factors include exposure to high levels of endogenous estrogen (eg, obesity, nulliparity, late menopause) or exogenous estrogen (eg, hormone replacement therapy, tamoxifen) and pelvic radiation. Genetics are involved in a small percentage of cases, notably among women in families with hereditary nonpolyposis colorectal cancer (HNPCC)...
November 2015: FP Essentials
https://www.readbyqxmd.com/read/26261678/endometrial-tubal-metaplasia-in-a-young-puerperal-woman-after-breast-cancer
#12
Luisa Di Benedetto, Valentina Giovanale, Donatella Caserta
INTRODUCTION: Tamoxifen is the usual endocrine (anti-estrogen) therapy for hormone receptor-positive breast cancer in pre and post-menopausal women. Previous studies have suggested an increased prevalence of endometrial diseases after treatment with tamoxifen. CASE PRESENTATION: The authors report a case of 38-year-old woman with diagnosis of endometrial polyp and tubal metaplasia, during puerperium and after micropapillary ductal breast cancer surgery, 5 years of tamoxifen treatment, spontaneous pregnancy without complications and full-term vaginal delivery...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26254516/the-medical-management-of-abnormal-uterine-bleeding-in-reproductive-aged-women
#13
REVIEW
Linda D Bradley, Ndeye-Aicha Gueye
In the treatment of women with abnormal uterine bleeding, once a thorough history, physical examination, and indicated imaging studies are performed and all significant structural causes are excluded, medical management is the first-line approach. Determining the acuity of the bleeding, the patient's medical history, assessing risk factors, and establishing a diagnosis will individualize their medical regimen. In acute abnormal uterine bleeding with a normal uterus, parenteral estrogen, a multidose combined oral contraceptive regimen, a multidose progestin-only regimen, and tranexamic acid are all viable options, given the appropriate clinical scenario...
January 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26251118/uterine-leiomyoma-stem-cells-linking-progesterone-to-growth
#14
REVIEW
Serdar E Bulun, Molly B Moravek, Ping Yin, Masanori Ono, John S Coon, Matthew T Dyson, Antonia Navarro, Erica E Marsh, Hong Zhao, Tetsuo Maruyama, Debabrata Chakravarti, J Julie Kim, Jian-Jun Wei
Uterine leiomyomas (fibroids) represent the most common class of benign tumors in women. Multiple leiomyomas usually arise from the uterus of a symptomatic woman. These tumors cause a variety of symptoms, including abnormal uterine bleeding, pelvic pain, bladder or bowel dysfunction, and recurrent pregnancy loss, and are responsible for more than 200,000 hysterectomies in the United States annually. Each leiomyoma seems to arise from the clonal expansion of a single myometrial smooth muscle cell transformed by a mutation...
September 2015: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/25767949/the-management-of-uterine-leiomyomas
#15
George A Vilos, Catherine Allaire, Philippe-Yves Laberge, Nicholas Leyland, Angelos G Vilos, Ally Murji, Innie Chen
OBJECTIVES: The aim of this guideline is to provide clinicians with an understanding of the pathophysiology, prevalence, and clinical significance of myomata and the best evidence available on treatment modalities. OPTIONS: The areas of clinical practice considered in formulating this guideline were assessment, medical treatments, conservative treatments of myolysis, selective uterine artery occlusion, and surgical alternatives including myomectomy and hysterectomy...
February 2015: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/25637505/scientific-evaluation-of-medicinal-plants-used-for-the-treatment-of-abnormal-uterine-bleeding-by-avicenna
#16
REVIEW
Masumeh Mobli, Marzieh Qaraaty, Gholamreza Amin, Ismaeil Haririan, Mannan Hajimahmoodi, Roja Rahimi
PURPOSE: Abnormal uterine bleeding (AUB) is one of the prevalent gynecological disorders that cause considerable morbidity and management of that plays an important role in protecting women's health. This review focuses on medicinal plants mentioned by Avicenna, a great Iranian philosopher and physician (A.D. 980-1037), in his book Canon for treatment of AUB. METHODS: Medicinal plants mentioned in Canon for treatment of AUB were elicited and searched in electronic databases including PubMed, Scopus, Google Scholar and Cochrane library to find studies that confirmed their efficacy...
July 2015: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25556427/antiproliferative-effect-of-metformin-on-the-endometrium-a-clinical-trial
#17
RANDOMIZED CONTROLLED TRIAL
Ali Dastranj Tabrizi, Manijeh Sayyah Melli, Meraj Foroughi, Morteza Ghojazadeh, Sanam Bidadi
BACKGROUND: Unopposed estrogen has a central role in development of endometrial benign, premalignant and malignant lesions. The aim of this study was to evaluate the anti-estrogenic effect of metformin on endometrial histology in comparison with progesterone. MATERIALS AND METHODS: A total of 43 patients who were referred to our center for abnormal uterine bleeding and had a histologic diagnosis were disordered proliferative endometrium or simple endometrial hyperplasia were included and randomly distributed in two groups treated with metformin (500mg Bid) or megestrol (40mg daily), respectively, for three months...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/25478358/sertoli-leydig-cell-tumour-of-ovary-with-menorrhagia-a-rare-case-report
#18
Umesh Sidheshwar Kanade, Sunita Sanjay Dantkale, Rahul Ravindra Narkhede, Rupali Ramrao Kurawar, Shubhada Yadavrao Bansode
Sertoli-Leydig cell tumours (SLCTs) are rare sex cord stromal neoplasms of ovary accounting for less than 0.5% of all ovarian tumours. These are found in women of all age groups (2-75 y), but are most common in reproductive age group with an average age of 25 y. Mostly these are unilateral, confined to ovaries and usually stage I at the time of clinical diagnosis. The common presenting complaints in these patients are due to either mass occupying lesion (mostly pelviabdominal mass and/or pain) or hormonal production (mostly androgen and more rarely oestrogen)...
October 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/25205766/ovarian-steroids-stem-cells-and-uterine-leiomyoma-therapeutic-implications
#19
REVIEW
Molly B Moravek, Ping Yin, Masanori Ono, John S Coon, Matthew T Dyson, Antonia Navarro, Erica E Marsh, Debabrata Chakravarti, J Julie Kim, Jian-Jun Wei, Serdar E Bulun
BACKGROUND: Uterine leiomyoma is the most common benign tumor in women and is thought to arise from the clonal expansion of a single myometrial smooth muscle cell transformed by a cellular insult. Leiomyomas cause a variety of symptoms, including abnormal uterine bleeding, pelvic pain, bladder or bowel dysfunction, and recurrent pregnancy loss, and are the most common indication for hysterectomy in the USA. A slow rate of cell proliferation, combined with the production of copious amounts of extracellular matrix, accounts for tumor expansion...
January 2015: Human Reproduction Update
https://www.readbyqxmd.com/read/24848920/committee-opinion-no-601-tamoxifen-and-uterine-cancer
#20
(no author information available yet)
Tamoxifen, a nonsteroidal antiestrogen agent, is widely used as adjunctive therapy for women with breast cancer, and it has been approved by the U.S. Food and Drug Administration for adjuvant treatment of breast cancer, treatment of metastatic breast cancer, and reduction in breast cancer incidence in high-risk women. Tamoxifen use may be extended to 10 years based on new data demonstrating additional benefit. Women taking tamoxifen should be informed about the risks of endometrial proliferation, endometrial hyperplasia, endometrial cancer, and uterine sarcomas, and any abnormal vaginal bleeding, bloody vaginal discharge, staining, or spotting should be investigated...
June 2014: Obstetrics and Gynecology
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