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https://www.readbyqxmd.com/read/28447439/lipid-abnormalities-in-type-2-diabetes-mellitus-patients-with-overt-nephropathy
#1
Sabitha Palazhy, Vijay Viswanathan
BACKGROUND: Diabetic nephropathy is a major complication of diabetes and an established risk factor for cardiovascular events. Lipid abnormalities occur in patients with diabetic nephropathy, which further increase their risk for cardiovascular events. We compared the degree of dyslipidemia among type 2 diabetes mellitus (T2DM) subjects with and without nephropathy and analyzed the factors associated with nephropathy among them. METHODS: In this retrospective study, T2DM patients with overt nephropathy were enrolled in the study group (n=89) and without nephropathy were enrolled in the control group (n=92)...
April 2017: Diabetes & Metabolism Journal
https://www.readbyqxmd.com/read/28446493/hospital-performance-on-percutaneous-coronary-intervention-process-and-outcomes-measures
#2
Philip W Chui, Craig S Parzynski, Brahmajee K Nallamothu, Frederick A Masoudi, Harlan M Krumholz, Jeptha P Curtis
BACKGROUND: The Physician Consortium for Performance Improvement recently proposed percutaneous coronary intervention (PCI)-specific process measures. However, information about hospital performance on these measures and the association of PCI process and outcomes measures are not available. METHODS AND RESULTS: We linked the National Cardiovascular Data Registry (NCDR) CathPCI Registry with Medicare claims data to assess hospital performance on established PCI process measures (aspirin, thienopyridines, and statins on discharge; door-to-balloon time; and referral to cardiac rehabilitation), newly proposed PCI process measures (documentation of contrast dose, glomerular filtration rate, and PCI indication; appropriate indication for elective PCI; and use of embolic protection device), and a composite of all process measures...
April 26, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28443676/pre-operative-nomograms-for-predicting-renal-function-at-1-year-after-partial-nephrectomy
#3
Cheuk Fan Shum, Clinton D Bahler, Clint Cary, Timothy A Masterson, Ronald S Boris, Thomas A Gardner, Hristos Z Kaimakliotis, Rick Foster, Richard Bihrle, Michael Koch, James E Slaven, Chandru P Sundaram
INTRODUCTION: Partial nephrectomy (PN) reduces the risk of post-operative chronic renal insufficiency (CRI). However, some patients still develop CRI after PN, and may eventually require dialysis. Being able to predict renal function before PN helps in counseling patients and managing expectations. We aimed to construct nomograms that predict estimated glomerular filtration rate (eGFR), defined by the Modification of Diet in Renal Disease (MDRD) and the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formulae, at one year after PN, using only pre-operative covariates as predictors...
April 26, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28443267/no-impact-of-the-analytical-method-used-for-determining-cystatin-c-on-estimating-glomerular-filtration-rate-in-children
#4
Martin Alberer, Julia Hoefele, Marcus R Benz, Arend Bökenkamp, Lutz T Weber
BACKGROUND: Measurement of inulin clearance is considered to be the gold standard for determining kidney function in children, but this method is time consuming and expensive. The glomerular filtration rate (GFR) is on the other hand easier to calculate by using various creatinine- and/or cystatin C (Cys C)-based formulas. However, for the determination of serum creatinine (Scr) and Cys C, different and non-interchangeable analytical methods exist. Given the fact that different analytical methods for the determination of creatinine and Cys C were used in order to validate existing GFR formulas, clinicians should be aware of the type used in their local laboratory...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28429520/performance-in-adolescents-of-the-two-japanese-serum-creatinine-based-estimated-glomerular-filtration-rate-equations-for-adults-and-paediatric-patients-a-study-of-the-japan-renal-biopsy-registry-and-japan-kidney-disease-registry-from-2007-to-2013
#5
Osamu Uemura, Hitoshi Yokoyama, Kenji Ishikura, Yoshimitsu Gotoh, Hiroshi Sato, Hitoshi Sugiyama, Masataka Honda, Seiichi Matsuo
There are two different Japanese serum creatinine-based equations for estimated glomerular filtration rate (eGFR), for adults and paediatric patients, with both equations deemed applicable to 18-year-old subjects. This study assessed the relative accuracy of the two equations in assessing eGFR in patients aged 18 years with chronic kidney disease. A total of 3042 patients (1679 males and 1363 females), aged 2-20 years, who were registered in the Japan Renal Biopsy Registry or the Japan Kidney Disease Registry between 2007 and 2013 were evaluated...
June 2017: Nephrology
https://www.readbyqxmd.com/read/28414748/dividing-ckd-stage-3-into-g3a-and-g3b-could-better-predict-the-prognosis-of-iga-nephropathy
#6
Jun-Jun Zhang, Gui-Zhen Yu, Zhao-Hui Zheng, Ya-Fei Liu, Yang-Yang Du, Song-Xia Quan, Yu-Jie Liu, Ji-Cheng Lv, Hong Zhang
Chronic kidney disease (CKD) stage 3 was divided into stage G3a and stage G3b in the 2013 Kidney Disease Improving Global Outcomes guidelines. Whether it is appropriate to regard 45 mL/min/per 1.73 m2 as the threshold value of G3a/G3b staging and whether dividing CKD stage 3 into G3a/G3b plays a useful role in assessing the prognosis of patients with IgA nephropathy (IgAN) remain unknown. Three hundred and ninety patients from the First Affiliated Hospital of Zhengzhou University and Peking University First Hospital diagnosed with IgAN in CKD stage 3 were enrolled and successfully followed up...
2017: PloS One
https://www.readbyqxmd.com/read/28413463/diagnostic-value-of-neutrophil-gelatinase-associated-lipocalin-for-renal-injury-in-asphyxiated-preterm-infants
#7
Yu'E Song, Shuzhen Sun, Yonghui Yu, Gang Li, Jia Song, Hong Zhang, Chunmei Yan
The aim of the present study was to analyze the diagnostic value of neutrophil gelatinase-associated lipocalin (NGAL) in renal injury in asphyxiated preterm infants. In total, 48 cases of asphyxiated preterm infants, 45 cases of premature infants and 45 cases of normal newborn infants were included in the study. Using ELISA we evaluated the level of urine NGAL, kidney injury molecule-1 (KIM-1), cystatin C (Cys-C) and serum creatinine (Scr). We also calculated the estimated glomerular filtration rate (eGFR)...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28406595/changes-in-estimated-glomerular-filtration-rate-over-time-in-south-african-hiv-1-infected-patients-receiving-tenofovir-a-retrospective-cohort-study
#8
Reneé De Waal, Karen Cohen, Matthew P Fox, Kathryn Stinson, Gary Maartens, Andrew Boulle, Ehimario U Igumbor, Mary-Ann Davies
INTRODUCTION: Tenofovir has been associated with decline in kidney function, but in patients with low baseline kidney function, improvements over time have been reported. Additionally, the magnitude and trajectory of estimated glomerular filtration rate (eGFR) changes may differ according to how eGFR is calculated. We described changes in eGFR over time, and the incidence of, and risk factors for, kidney toxicity, in a South African cohort. METHODS: We included antiretroviral-naïve patients ≥16 years old who started tenofovir-containing antiretroviral therapy (ART) between 2002 and 2013...
April 10, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28403599/renal-extracapsular-hypoechoic-rim-and-kidney-cortical-thickness
#9
Simone Brardi, Gabriele Cevenini, Roberto Ponchietti, Giuseppe Romano, Ennio Duranti
OBJECTIVES: A renal extracapsular hypoechoic rim was previously recognized and interpreted as a typical sonographic finding of renal failure. Subsequently it was hypothesized that the hypoechoic rim could be produced by a state of sodium retention and oedema caused by nephropathy but not necessarily associated with renal failure. In order to get this cleared we performed a retrospective analysis of 80 renal ultrasound examinations, carried out at our center, in 41 of which it was found a renal extracapsular hypoechoic rim...
March 31, 2017: Archivio Italiano di Urologia, Andrologia
https://www.readbyqxmd.com/read/28401356/development-of-novel-nomograms-to-predict-renal-functional-outcomes-after-laparoscopic-adrenalectomy-in-patients-with-primary-aldosteronism
#10
Takanobu Utsumi, Naoto Kamiya, Mayuko Kaga, Takumi Endo, Masashi Yano, Shuichi Kamijima, Koji Kawamura, Takashi Imamoto, Tomohiko Ichikawa, Hiroyoshi Suzuki
PURPOSE: Most patients with primary aldosteronism (PA) show a significant decrease in kidney function after surgery. Glomerular hyperfiltration peculiar to PA can mask mild renal failure before surgery. The aim of this retrospective study was to investigate postoperative renal functional outcomes in PA patients from different viewpoints and to develop novel nomograms that can predict renal functional outcomes in PA patients after surgery. METHODS: 130 Japanese PA patients treated by unilateral laparoscopic adrenalectomy were retrospectively surveyed...
April 11, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28399132/effect-of-prescribing-metformin-according-to-egfr-instead-of-serum-creatinine-level-a-study-based-on-korean-national-health-and-nutrition-examination-survey-knhanes-2009-2014
#11
Sun Joon Moon, Chang Ho Ahn, Young Min Cho
BACKGROUND: The metformin label has recently been changed from serum creatinine (sCr)-based to estimated glomerular filtration rate (eGFR)-based indication, which is expected to expand its use for patients with mild renal insufficiency. However, because the sCr level is lower in Asians than in Caucasians at the same level of renal function, this change might not expand metformin use in the Asian population. We investigated the effect of this change among Korean patients with diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28399042/pre-end-stage-renal-disease-visit-to-visit-systolic-blood-pressure-variability-and-post-end-stage-renal-disease-mortality-in-incident-dialysis-patients
#12
Keiichi Sumida, Miklos Z Molnar, Praveen K Potukuchi, Fridtjof Thomas, Jun Ling Lu, Kunihiro Yamagata, Kamyar Kalantar-Zadeh, Csaba P Kovesdy
OBJECTIVES: Higher SBP visit-to-visit variability (SBPV) has been associated with increased risk of adverse events in patients with chronic kidney disease, but the association of SBPV in advanced nondialysis-dependent chronic kidney disease with mortality after the transition to end-stage renal disease (ESRD) remains unknown. METHODS: Among 17 729 US veterans transitioning to dialysis between October 2007 and September 2011, we assessed SBPV calculated from the SD of at least three intraindividual outpatient SBP values during the last year prior to dialysis transition (prelude period)...
April 10, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28397072/automated-renal-cortical-volume-measurement-for-assessment-of-renal-function-in-patients-undergoing-radical-nephrectomy
#13
Hirofumi Shimoyama, Shuji Isotani, Toshiyuki China, Masayoshi Nagata, Isao Yokota, Kosuke Kitamura, Yoshiaki Wakumoto, Hisamitsu Ide, Satoru Muto, Akira Tujimura, Raizo Yamaguchi, Shigeo Horie
BACKGROUND: Renal volume change greatly affects renal function after nephrectomy. Although various measuring techniques were reported, no standard measuring method is available. In this study, we examined the computational automated volumetric method, and evaluated the volumetric change to assess the functional outcome in patients undergoing radical nephrectomy. We developed the predictive equation for postoperative renal function from volume alternation and validated the performance...
April 10, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28396736/the-clinical-utility-of-kinetic-glomerular-filtration-rate
#14
Eoin D O'Sullivan, Arthur Doyle
Background: In acutely unwell patients with rapidly changing renal function, estimating glomerular filtration rate (GFR) and predicting adverse renal outcomes are challenging and often inaccurate. Kinetic GFR (kGFR) is an estimate of immediate biomarker clearance derived from two discreet measurements that may better represent acute function. Our objective is to assess the clinical utility of kGFR as a predictive tool and examine the association of kGFR to adverse renal outcomes compared with measurements to traditional estimates...
April 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/28395289/urinary-angiotensinogen-and-renin-excretion-are-associated-with-chronic-kidney-disease
#15
Annett Juretzko, Antje Steinbach, Anke Hannemann, Karlhans Endlich, Nicole Endlich, Nele Friedrich, Uwe Lendeckel, Sylvia Stracke, Rainer Rettig
BACKGROUND/AIMS: Several studies sought to identify new biomarkers for chronic kidney disease (CKD). As the renal renin-angiotensin system is activated in CKD, urinary angiotensinogen or renin excretion may be suitable candidates. We tested whether urinary angiotensinogen or renin excretion is elevated in CKD and whether these parameters are associated with estimated glomerular filtration rate (eGFR). We further tested whether urinary angiotensinogen or renin excretion may convey additional information beyond that provided by albuminuria...
April 11, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28391915/plasma-pcsk9-concentrations-during-the-course-of-nondiabetic-chronic-kidney-disease-relationship-with-glomerular-filtration-rate-and-lipid-metabolism
#16
Marion Morena, Cédric Le May, Leila Chenine, Lucie Arnaud, Anne-Marie Dupuy, Matthieu Pichelin, Hélène Leray-Moragues, Lotfi Chalabi, Bernard Canaud, Jean-Paul Cristol, Bertrand Cariou
BACKGROUND: The association between proprotein convertase subtilisin/kexin type 9 (PCSK9), a critical regulator of low-density lipoprotein (LDL) metabolism, and kidney function is a matter of debate. OBJECTIVE: We aimed to assess the association of circulating PCSK9 concentrations with both glomerular filtration rate (eGFR) and serum lipid parameters in nondiabetic patients with chronic kidney disease (CKD). METHODS: Fasting plasma PCSK9 concentrations were measured by ELISA in 94 nondiabetic nondialysis CKD (ND-CKD) patients not receiving statins, at different stages of CKD...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28378551/changes-in-urinary-angiotensinogen-associated-with-deterioration-of-kidney-function-in-patients-with-type-2-diabetes-mellitus
#17
Min Jin Lee, Sang Soo Kim, In Joo Kim, Sang Heon Song, Eun Heui Kim, Ji Yeong Seo, Jong Ho Kim, Sungsu Kim, Yun Kyung Jeon, Bo Hyun Kim, Yong Ki Kim
Urinary angiotensinogen (AGT) is potentially a specific biomarker for the status of the intrarenal renin-angiotensin system (RAS) in patients with diabetes mellitus. We explored whether changes in urinary AGT excretion levels were associated with the deterioration of kidney function in type 2 diabetes patients with preserved kidney function. Urinary baseline AGT levels were measured in 118 type 2 diabetic patients who were not taking RAS blockers and who had estimated glomerular filtration rates (eGFRs) ≥ 60 mL/min/1...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28373588/vascular-stiffness-in-children-with-chronic-kidney-disease
#18
Jonathan D Savant, Aisha Betoko, Kevin E C Meyers, Mark Mitsnefes, Joseph T Flynn, Raymond R Townsend, Larry A Greenbaum, Allison Dart, Bradley Warady, Susan L Furth
Carotid-femoral pulse wave velocity (cfPWV) is a measure of arterial stiffness associated with cardiovascular events in the general population and in adults with chronic kidney disease. However, few data exist regarding cfPWV in children with chronic kidney disease. We compared observed cfPWV assessed via applanation tonometry in children enrolled in the CKiD cohort study (Chronic Kidney Disease in Children) to normative data in healthy children and examined risk factors associated with elevated cfPWV. cfPWV Z score for height/gender and age/gender was calculated from and compared with published pediatric norms...
May 2017: Hypertension
https://www.readbyqxmd.com/read/28372539/prevalence-of-chronic-kidney-disease-associated-with-cardiac-and-vascular-complications-in-hypertensive-patients-a-multicenter-nation-wide-study-in-thailand
#19
Rungroj Krittayaphong, Ram Rangsin, Bandit Thinkhamrop, Cameron Hurst, Suthee Rattanamongkolgul, Nintita Sripaiboonkij, Wipaporn Wangworatrakul
BACKGROUND: Hypertension and chronic kidney disease (CKD) are common conditions and both are major risk factors for cardiovascular events. The objectives were 1) to study the prevalence of CKD in hypertensive patients and 2) to study the association of CKD with cardiac and vascular complications in a multicenter, nation-wide fashion. METHODS: This cross-sectional study evaluated patients aged 20 years or older who were diagnosed with hypertension and who had been treated for at least 12 months at 831 public hospitals in Thailand during the 2012 study period...
April 3, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28369190/physical-activity-is-associated-with-reduced-left-ventricular-mass-in-obese-and-hypertensive-african-americans
#20
Daisuke Kamimura, Paul D Loprinzi, Wanmei Wang, Takeki Suzuki, Kenneth R Butler, Thomas H Mosley, Michael E Hall
BACKGROUND: Physical activity (PA) has been associated with decreased left ventricular (LV) hypertrophy in previous studies. However, little is known about the relationship between PA and LV structure and factors which influence this relationship among African Americans. METHODS: We evaluated 1,300 African Americans with preserved LV ejection fraction (EF > 50%) from the Genetic Epidemiology Network of Arteriopathy (GENOA) Study (mean age 62.4 years, 73% women)...
March 20, 2017: American Journal of Hypertension
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