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valerian root

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https://www.readbyqxmd.com/read/29121679/quality-control-of-valerianae-radix-by-attenuated-total-reflection-fourier-transform-infrared-atr-ftir-spectroscopy
#1
Ramin Nikzad-Langerodi, Katharina Arth, Valerie Klatte-Asselmeyer, Sabine Bressler, Johannes Saukel, Gottfried Reznicek, Christoph Dobeš
(Acetoxy-)valerenic acid and total essential oil content are important quality attributes of pharmacy grade valerian root (Valerianae radix). Traditional analysis of these quantities is time-consuming and necessitates (harmful) solvents. Here we investigated an application of attenuated total reflection Fourier transform infrared spectroscopy for extractionless analysis of these quality attributes on a representative sample comprising 260 wild-crafted individuals covering the Central European taxonomic diversity of the Valeriana officinalis L...
November 9, 2017: Planta Medica
https://www.readbyqxmd.com/read/28988031/metabolic-engineering-of-escherichia-coli-for-production-of-valerenadiene
#2
S Eric Nybo, Jacqueline Saunders, Sean P McCormick
Valeriana officinalis is a medicinal herb which produces a suite of compounds in its root tissue useful for treatment of anxiety and insomnia. The sesquiterpene components of the root extract, valerenic acid and valerena-1,10-diene, are thought to contribute to most of the observed anxiolytic of Valerian root preparations. However, valerenic acid and its biosynthetic intermediates are only produced in low quantities in the roots of V. officinalis. Thus, in this report, Escherichia coli was metabolically engineered to produce substantial quantities of valerena-1,10-diene in shake flask fermentations with decane overlay...
October 5, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28970454/community-pharmacists-knowledge-regarding-donepezil-averse-effects-and-self-care-recommendations-for-insomnia-for-persons-with-ad
#3
Marketa Marvanova, Paul Jacob Henkel
Alzheimer's disease (AD) impacts millions of individuals worldwide. Since no cure is currently available, acetylcholinesterase inhibitors are symptomatic therapy. This study assessed community pharmacists' knowledge regarding donepezil adverse effects (AEs) and self-care recommendations for insomnia management for persons with AD treated with rivastigmine. This is a cross-sectional, standardized telephone survey of community pharmacists (n = 862) in three study areas: West Virginia, North Dakota/South Dakota, and Southern Oregon/Northern California...
July 28, 2017: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/28302120/responsiveness-of-cats-felidae-to-silver-vine-actinidia-polygama-tatarian-honeysuckle-lonicera-tatarica-valerian-valeriana-officinalis-and-catnip-nepeta-cataria
#4
COMPARATIVE STUDY
Sebastiaan Bol, Jana Caspers, Lauren Buckingham, Gail Denise Anderson-Shelton, Carrie Ridgway, C A Tony Buffington, Stefan Schulz, Evelien M Bunnik
BACKGROUND: Olfactory stimulation is an often overlooked method of environmental enrichment for cats in captivity. The best known example of olfactory enrichment is the use of catnip, a plant that can cause an apparently euphoric reaction in domestic cats and most of the Pantherinae. It has long been known that some domestic cats and most tigers do not respond to catnip. Although many anecdotes exist of other plants with similar effects, data are lacking about the number of cats that respond to these plants, and if cats that do not respond to catnip respond to any of them...
March 16, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28096376/myosin-driven-transport-network-in-plants
#5
Elizabeth G Kurth, Valera V Peremyslov, Hannah L Turner, Kira S Makarova, Jaime Iranzo, Sergei L Mekhedov, Eugene V Koonin, Valerian V Dolja
We investigate the myosin XI-driven transport network in Arabidopsis using protein-protein interaction, subcellular localization, gene knockout, and bioinformatics analyses. The two major groups of nodes in this network are myosins XI and their membrane-anchored receptors (MyoB) that, together, drive endomembrane trafficking and cytoplasmic streaming in the plant cells. The network shows high node connectivity and is dominated by generalists, with a smaller fraction of more specialized myosins and receptors...
February 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27681079/acute-severe-hyponatraemia-secondary-to-polydipsia-and-associated-herbal-remedy-use
#6
Oliver T R Toovey, Ian R Edmond, Nikolaos Makris
A 47-year-old woman presented with seizures secondary to euvolaemic hyponatraemia. A collateral history revealed recent increased oral fluid intake and increased use of herbal remedies including valerian root over the New Year period. There was no history of psychiatric disease to support psychogenic polydipsia. She responded to careful sodium replacement in the intensive care unit and was discharged with no neurological sequelae.
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27419099/the-effect-of-valerian-root-extract-on-the-severity-of-pre-menstrual-syndrome-symptoms
#7
Zahra Behboodi Moghadam, Elham Rezaei, Roghaieh Shirood Gholami, Masomeh Kheirkhah, Hamid Haghani
Premenstrual syndrome (PMS) is a common disorder. Due to the knowledge lack of the precise etiology of this syndrome, different treatment methods are recommended, one of them is the use of medicinal herbs. This study aimed to investigate the effect of Valerian ( xié cǎo) root extract on the intensity of PMS symptoms. In this double-blind clinical trial, 100 female students of Islamic Azad University, Tonekabon Branch, Mazandaran Province, Iran, with PMS were randomly divided into groups receiving Valerian (scientific name: Valeriana officinalis) and placebo in 2013...
July 2016: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/27165438/reversal-of-pentylenetetrazole-altered-swimming-and-neural-activity-regulated-gene-expression-in-zebrafish-larvae-by-valproic-acid-and-valerian-extract
#8
Bianca A Torres-Hernández, Luis R Colón, Coral Rosa-Falero, Aranza Torrado, Nahira Miscalichi, José G Ortíz, Lorena González-Sepúlveda, Naydi Pérez-Ríos, Erick Suárez-Pérez, John N Bradsher, Martine Behra
RATIONALE: Ethnopharmacology has documented hundreds of psychoactive plants awaiting exploitation for drug discovery. A robust and inexpensive in vivo system allowing systematic screening would be critical to exploiting this knowledge. OBJECTIVE: The objective of this study was to establish a cheap and accurate screening method which can be used for testing psychoactive efficacy of complex mixtures of unknown composition, like plant crude extracts. METHODS: We used automated recording of zebrafish larval swimming behavior during light vs...
July 2016: Psychopharmacology
https://www.readbyqxmd.com/read/27149780/-transition-of-psychotropic-drugs-in-japanese-pharmacopoeia-jp-part-16-transitions-in-the-standards-and-test-methods-of-bromovalerylurea-in-jp-v-1932-and-jp-x-vi-2011-and-comparison-with-deutsches-arzneibuch
#9
COMPARATIVE STUDY
Kiyohisa Yanagisawa
Soam discovered the drug Bromovalerylurea (or less BV) in 1907. After that, BV was imported in Japan in the latter part of the Meiji period as Western medicine. Under the influence of the First World War, in Japan, BV was domestic production. And BV are listed in JP V (1932), it is continued listing until the current JP X VI (2011). As a foreign pharmacopoeia which listed the BV, only in addition to the JP, there was a German Pharmacopoeia (DAB). During this time, the JP and DAB, the standards and test methods of BV, it was amended as shown in Table 1 and Table 2...
2015: Yakushigaku Zasshi. the Journal of Japanese History of Pharmacy
https://www.readbyqxmd.com/read/26920719/regulation-of-sesquiterpenoid-metabolism-in-recombinant-and-elicited-valeriana-officinalis-hairy-roots
#10
Vincent Ricigliano, Santosh Kumar, Scott Kinison, Christopher Brooks, S Eric Nybo, Joe Chappell, Dianella G Howarth
The medicinal properties of Valerian (Valeriana officinalis) root preparations are attributed to the anxiolytic sesquiterpenoid valerenic acid and its biosynthetic precursors valerenal and valerenadiene, as well as the anti-inflammatory sesquiterpenoid β-caryophyllene. In order to study and engineer the biosynthesis of these pharmacologically active metabolites, a binary vector co-transformation system was developed for V. officinalis hairy roots. The relative expression levels and jasmonate-inducibility of a number of genes associated with sesquiterpenoid metabolism were profiled in roots: farnesyl pyrophosphate synthase (VoFPS), valerendiene synthase (VoVDS), germacrene C synthase (VoGCS), and a cytochrome P450 (CYP71D442) putatively associated with terpene metabolism based on sequence homology...
May 2016: Phytochemistry
https://www.readbyqxmd.com/read/26465629/valerian-root-and-lemon-balm-extracts-a-phytomedicine-compound-improves-symptoms-of-hyperactivity-attention-deficits-and-impulsivity-in-children
#11
MULTICENTER STUDY
Stephanie Maxine Ross
No abstract text is available yet for this article.
November 2015: Holistic Nursing Practice
https://www.readbyqxmd.com/read/26434106/isolation-of-monovalerianester-a-an-inhibitor-of-fat-accumulation-from-valeriana-fauriei
#12
Keiji Yuki, Mariko Ikeda, Shosuke Yoshida, Osamu Ohno, Kiyotake Suenaga, Kaoru Yamada, Daisuke Uemura, Kenji Miyamoto
The rhizomes and roots of Valeriana fauriei were extracted with 80% aqueous ethanol. This extract was found to exhibit potent inhibitory effects on fat accumulation in 3T3-LI murine adipocytes. After several steps of chromatographic purification, we succeeded in identifying monovalerianester A as an inhibitor of fat accumulation. Thus, monovalerianester A and the crude extract of the rhizomes and roots of V. fauriei may have therapeutic potential for the treatment of obesity.
August 2015: Natural Product Communications
https://www.readbyqxmd.com/read/26390643/-development-and-research-advances-of-iridoids-from-valeriana-jatamansi-and-their-bioactivity
#13
REVIEW
Ning-ning Zhang, Guang-zhi Ding
Valeriana jatamansi (syn. V. wallichii), a traditional Chinese medicine recorded in Chinese Pharmacopeia (1977 and 2010 edition), has been used for treatment of a variety of conditions including sleep problems, obesity, nervous disorders, epilepsy, insanity, snake poisoning, eye trouble, and skin diseases. Also, it was used as an important substitute for the European V. officinalis, whose root preparation, popularly known as valerian, has been employed as a mild sedative for a long time. In recent years, much attention has been draw to the iridoids, one of the major bioactive constituents of V...
May 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26168917/valerenic-acid-and-valeriana-officinalis-extracts-delay-onset-of-pentylenetetrazole-ptz-induced-seizures-in-adult-danio-rerio-zebrafish
#14
Bianca A Torres-Hernández, Lisa M Del Valle-Mojica, José G Ortíz
BACKGROUND: Anticonvulsant properties have been attributed to extracts of the herbal medicine Valeriana officinalis. Our aims were to examine the anticonvulsant properties of valerenic acid and valerian extracts and to determine whether valerian preparations interact with the activity of other anti-epileptic drugs (phenytoin or clonazepam). To achieve these goals, we validated the adult zebrafish, Danio rerio, as an animal model for studying anticonvulsant drugs. METHODS: All drug treatments were administered by immersion in water containing the drug...
July 14, 2015: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/25799839/-transitions-of-psychotropic-drugs-in-the-japanese-pharmacopoeia-jp-part-14-transitions-in-the-standards-and-test-methods-of-valerian-root-in-the-deutsches-arzneibuch-dab-and-comparison-between-the-usp-bp-ep-and-jp-and-oleum-valerianae-japan-kesso-oil-listed
#15
COMPARATIVE STUDY
Kiyohisa Yanagisawa
Valerian has been used as a name for Japanese Valerian and European Valerian root. Valerian in the German market today was originally called Baldrian. Transitions in the standards and the test methods of Valerian root listed in the DAB were studied this time. Moreover, we compared these standards and test methods with those in the USP, BP, EP and JP. We also considered the pharmacology evaluation in Germany. At the time, the standards and test methods had content in accordance with the EP from DAB9 (1986) of the West Germany publication...
2014: Yakushigaku Zasshi. the Journal of Japanese History of Pharmacy
https://www.readbyqxmd.com/read/25785762/valeriana-officinalis-extracts-ameliorate-neuronal-damage-by-suppressing-lipid-peroxidation-in-the-gerbil-hippocampus-following-transient-cerebral-ischemia
#16
Dae Young Yoo, Hyo Young Jung, Sung Min Nam, Jong Whi Kim, Jung Hoon Choi, Youn-Gil Kwak, Miyoung Yoo, Sanghee Lee, Yeo Sung Yoon, In Koo Hwang
As a medicinal plant, the roots of Valeriana officinalis have been used as a sedative and tranquilizer. In the present study, we evaluated the neuroprotective effects of valerian root extracts (VE) on the hippocampal CA1 region of gerbils after 5 min of transient cerebral ischemia. Gerbils were administered VE orally once a day for 3 weeks, subjected to ischemia/reperfusion injury, and continued on VE for 3 weeks. The administration of 100 mg/kg VE (VE100 group) significantly reduced the ischemia-induced spontaneous motor hyperactivity 1 day after ischemia/reperfusion...
June 2015: Journal of Medicinal Food
https://www.readbyqxmd.com/read/25771806/origins-and-evolution-of-viruses-of-eukaryotes-the-ultimate-modularity
#17
REVIEW
Eugene V Koonin, Valerian V Dolja, Mart Krupovic
Viruses and other selfish genetic elements are dominant entities in the biosphere, with respect to both physical abundance and genetic diversity. Various selfish elements parasitize on all cellular life forms. The relative abundances of different classes of viruses are dramatically different between prokaryotes and eukaryotes. In prokaryotes, the great majority of viruses possess double-stranded (ds) DNA genomes, with a substantial minority of single-stranded (ss) DNA viruses and only limited presence of RNA viruses...
May 2015: Virology
https://www.readbyqxmd.com/read/25707840/morphologic-variations-in-mandibular-premolars-a-report-of-three-cases
#18
Anuj Bhardwaj, Jojo Kottoor, Denzil Valerian Albequerque, Natanasabapathy Velmurugan
AIM: To report cases with morphologic variations in mandibular premolars. BACKGROUND: Mandibular premolars have earned the reputation for having aberrant anatomy. The occurrence of three canals with three separate (type V, Vertucci) foramina in mandibular premolars is very rare. In this report, three cases are presented involving the root canal treatment of mandibular premolars with three different root and canal configurations. The present report also emphasizes the use of the dental operating microscope to enhance visualization...
September 1, 2014: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/25665939/iridoids-and-sesquiterpenoids-from-the-roots-of-valeriana-jatamansi-jones
#19
Fa-Wu Dong, Liu Yang, Zhi-Kun Wu, Wei-Gao, Chen-Ting Zi, Dan Yang, Huai-Rong Luo, Jun Zhou, Jiang-Miao Hu
Three new iridoids, jatamanvaltrates R-S (1-2) and jatamanin Q (3), as well as three new sesquiterpenoids, valeriananoids D-E (4, 5) and clovane-2β-isovaleroxy-9α-ol (6), together with nine known compounds were isolated from the roots of Valeriana jatamansi Jones. Compound 2 was the first reported iridoid with fatty acid esters in the Valerianaceae family. The structures of new compounds were established on the basis of extensive spectroscopic analysis. Moreover, all the isolates were evaluated for inhibitory activity on acetylcholinesterase (AChE)...
April 2015: Fitoterapia
https://www.readbyqxmd.com/read/25643147/the-volatile-oil-of-nardostachyos-radix-et-rhizoma-induces-endothelial-nitric-oxide-synthase-activity-in-huvec-cells
#20
Maitinuer Maiwulanjiang, Cathy W C Bi, Pinky S C Lee, Guizhong Xin, Abudureyimu Miernisha, Kei M Lau, Aizhen Xiong, Ning Li, Tina T X Dong, Haji A Aisa, Karl W K Tsim
Nardostahyos Radix et Rhizoma (NRR; the root and rhizome of Nardostachys jatamansi DC.) is a widely used medicinal herb. Historically, NRR is being used for the treatment of cardiovascular and neurological diseases. To search for active ingredients of NRR, we investigated the vascular benefit of NRR volatile oil in (i) the vasodilation in rat aorta ring, and (ii) the release of nitric oxide (NO) and the phosphorylation of endothelial NO synthase (eNOS) in cultured human umbilical vein endothelial cells (HUVECs)...
2015: PloS One
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