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allergen cross-reactivity

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https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#1
Simon Blank, Maria Beatrice Bilò, Markus Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
January 13, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29327359/contact-sensitization-in-dental-technicians-with-occupational-contact-dermatitis-data-of-the-information-network-of-departments-of-dermatology-ivdk-2001-2015
#2
Annice Heratizadeh, Thomas Werfel, Steffen Schubert, Johannes Geier
BACKGROUND: Dental technicians (DTs) are at increased risk for allergic contact sensitization. OBJECTIVES: To assess the current spectrum of occupational sensitization in DTs with occupational contact dermatitis (OCD). METHODS: A retrospective analysis of Information Network of Departments of Dermatology patch test data from the years 2001-2015 concerning DTs with OCD was performed. RESULTS: Patients of the study group (226 DTs with OCD) were significantly more often diagnosed with allergic contact dermatitis (37...
January 12, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29319884/similar-localization-of-conformational-ige-epitopes-on-the-house-dust-mite-allergens-der-p-5-and-der-p-21-despite-limited-ige-cross-reactivity
#3
M Curin, T Garmatiuk, Y Resch-Marat, K W Chen, G Hofer, K Fauland, W Keller, W Hemmer, S Vrtala, M Focke-Tejkl, R Valenta
BACKGROUND: Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterise the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity. METHODS: A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were synthesized to search for sequential IgE epitopes by direct testing for allergic patients ' IgE reactivity...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29315948/a-patient-specific-approach-to-developing-an-exclusion-diet-to-manage-food-allergy-in-infants-and-children
#4
Carina Venter, Marion Groetch, Merryn Netting, Rosan Meyer
Food allergy is becoming increasingly common in infants and young children. This paper set out to explain the different factors that should be taken into account during an individualized allergy consultation: Foods to avoid and degree of avoidance, suitable alternatives, self-management skills, co-and cross-reactive allergens and novel allergens alongside the role of the industry in allergen avoidance, importance of nutritional aspects of the diet and the future directions that nutritional guidance make take...
January 8, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29315611/isolation-of-a-high-affinity-bet-v-1-specific-igg-derived-scfv-from-a-subject-vaccinated-with-hypoallergenic-bet-v-1-fragments
#5
Elisabeth Gadermaier, Katharina Marth, Christian Lupinek, Raffaela Campana, Gerhard Hofer, Katharina Blatt, Dubravka Smiljkovic, Uwe Roder, Margarete Focke-Tejkl, Susanne Vrtala, Walter Keller, Peter Valent, Rudolf Valenta, Sabine Flicker
BACKGROUND: Recombinant hypoallergenic allergen derivatives have been used in clinical immunotherapy studies and clinical efficacy seems to be related to the induction of blocking IgG antibodies recognizing the wild type allergens. However, so far no treatment-induced IgG antibodies have been characterized. OBJECTIVE: To clone, express and characterize IgG antibodies induced by vaccination with two hypoallergenic recombinant fragments of the major birch pollen allergen, Bet v 1 in a non-allergic subject...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29287414/thermal-processing-effects-on-the-ige-reactivity-of-cashew-and-pistachio
#6
Africa Sanchiz, Carmen Cuadrado, Maria Carmen Dieguez, Isabel Ballesteros, Julia Rodríguez, Jesus F Crespo, Natividad de Las Cuevas, Julia Rueda, Rosario Linacero, Beatriz Cabanillas, Natalija Novak
Thermal processing can modify the structure and function of food proteins and may alter their allergenicity. This work aimed to elucidate the influence of moist thermal treatments on the IgE-reactivity of cashew and pistachio. IgE-western blot and IgE-ELISA were complemented by Skin Prick Testing (SPT) and mediator release assay to determine the IgE cross-linking capability of treated and untreated samples. Moist thermal processing diminished the IgE-binding properties of both nuts, especially after heat/pressure treatment...
April 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29258956/approaches-to-assess-ige-mediated-allergy-risks-sensitization-and-cross-reactivity-from-new-or-modified-dietary-proteins
#7
REVIEW
B Remington, H C H Broekman, W M Blom, A Capt, R W R Crevel, I Dimitrov, C K Faeste, R Fernandez-Canton, S Giavi, G F Houben, K C Glenn, C B Madsen, A K Kruizinga, A Constable
The development and introduction of new dietary protein sources has the potential to improve food supply sustainability. Understanding the potential allergenicity of these new or modified proteins is crucial to ensure protection of public health. Exposure to new proteins may result in de novo sensitization, with or without clinical allergy, or clinical reactions through cross-reactivity. In this paper we review the potential of current methodologies (in silico, in vitro degradation, in vitro IgE binding, animal models and clinical studies) to address these outcomes for risk assessment purposes for new proteins, and especially to identify and characterise the risk of sensitization for IgE mediated allergy from oral exposure...
December 16, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29242143/increased-ratio-of-pollock-roe-specific-ige-to-salmon-roe-specific-ige-levels-is-associated-with-a-positive-reaction-to-cooked-pollock-roe-oral-food-challenge
#8
Eishi Makita, Noriyuki Yanagida, Sakura Sato, Tomoyuki Asaumi, Motohiro Ebisawa
BACKGROUND: Anaphylaxis and immediate-type fish roe allergies have been reported worldwide, and, in Japan, fish roe is the sixth most common food allergen. No oral food challenges (OFCs) have used pollock roe (PR), which is reported to have high cross-reactivity with salmon roe (SR). Therefore, we administered an OFC using cooked PR to evaluate PR- and SR-specific immunoglobulin E (IgE) levels and allergic reactions in patients with PR sensitivity. METHODS: This retrospective study evaluating patient characteristics and responses to OFCs was conducted with 10-20 g of cooked PR, between April 2006 and November 2016...
December 11, 2017: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29232483/epitope-resolved-detection-of-peanut-specific-ige-antibodies-by-spr-imaging
#9
Min Shen, Amit Joshi, Raghu Vannam, Chandra Dixit, Robert Hamilton, Challa V Kumar, James F Rusling, Mark Wayne Peczuh
Peanut allergy can be life-threatening and is mediated by allergen-specific immunoglobulin E (IgE) antibodies. Investigation of IgE antibody binding to allergenic epitopes identifies specific interactions underlying the allergic response. Here we report a surface plasmon resonance imaging (SPRi) immunoassay for differentiating IgE antibodies by epitope resolved detection. IgE antibodies are first captured by magnetic beads bearing IgE ε-chain specific antibodies and then introduced to an SPRi array immobilized with epitopes from the major peanut allergen glycoprotein Arachis hypogaea h2 (Ara h2)...
December 12, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29202918/almond-or-mahaleb-orthogonal-allergen-analysis-during-a-live-incident-investigation-by-elisa-molecular-biology-and-protein-mass-spectrometry
#10
Michael J Walker, Malcolm Burns, Milena Quaglia, Gavin Nixon, Christopher J Hopley, Kirstin M Gray, Victoria Moore, Malvinder Singh, Simon Cowen
It is now well known that an incident investigated in the United Kingdom in 2015 of cumin alleged to be contaminated with almond, a risk for people with almond allergy, was caused by the Prunus species, Prunus mahaleb. In the United Kingdom, the Government Chemist offers a route of technical appeal from official findings in the food control system. Findings of almond in two official samples, cumin and paprika, which had prompted action to exclude the consignments from the food chain, were so referred. Herein are described the approaches deployed to resolve the analytical issues during the investigation of the incidents...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202912/assessing-almond-and-peanut-allergens-using-commercially-available-immunoanalytical-kits-and-lc-ms-ms-a-case-study
#11
Matthew Daly, Parisa Ansari, Georg Häubl, Adrian Rogers, Kurt Brunner
With an ever-increasing allergic population and an emerging market for allergen-free foods, accurate detectionof allergens in foods has never been more important. Although ELISA-based methods are the most widely used for detection of allergens in food, there is a need for the development of orthogonal approaches. A commercial ELISA detected a relatively high concentration of peanut and almond in an allergen-free product. However, another commercial ELISA declared a low peanut concentration and was negative for almond...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29202909/commercial-elisa-measurement-of-allergens-and-gluten-what-we-can-learn-from-case-studies
#12
Markus Lacorn, Stella Lindeke, Susanne Siebeneicher, Thomas Weiss
During the last decade, results from ELISA test kits have often been criticized as being flawed. Therefore, itmay appear counterintuitive that ELISAs are used for most food allergen and gluten analytical needs. One reason, in addition to the nonavailability of comparable alternative methods, is the fact that the methods used underwent a long validation and learning period in the market. This publication presents several case studies on interference, cross-reactivity issues, calibrators, fragmented allergens and gluten, matrix influences, and misunderstood intended-use statements...
December 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/29200762/allergen-sensitization-pattern-by-sex-a-cluster-analysis-in-korea
#13
Jungyoon Ohn, Seung Hwan Paik, Eun Jin Doh, Hyun-Sun Park, Hyun-Sun Yoon, Soyun Cho
Background: Allergens tend to sensitize simultaneously. Etiology of this phenomenon has been suggested to be allergen cross-reactivity or concurrent exposure. However, little is known about specific allergen sensitization patterns. Objective: To investigate the allergen sensitization characteristics according to gender. Methods: Multiple allergen simultaneous test (MAST) is widely used as a screening tool for detecting allergen sensitization in dermatologic clinics...
December 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/29199966/occupational-asthma-and-urticaria-in-a-fishmonger-due-to-creatine-kinase-a-cross-reactive-fish-allergen
#14
X Larco-Rojas, M L González-Gutiérrez, S Vázquez-Cortés, B Bartolomé, C Pastor-Vargas, M Fernández-Rivas
No abstract text is available yet for this article.
2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/29178679/detecting-allergens-from-black-tiger-shrimp-penaeus-monodon-that-can-bind-and-cross-link-ige-by-elisa-western-blot-and-a-humanized-rat-basophilic-leukemia-reporter-cell-line-rs-atl8
#15
Thanyapat Jarupalee, Pantipa Chatchatee, Kittinan Komolpis, Narissara Suratannon, Sittiruk Roytrakul, Yodying Yingchutrakul, Wanaporn Yimchuen, Patcharavadee Butta, Alain Jacquet, Tanapat Palaga
BACKGROUND: Black tiger shrimp Penaeus monodon is one of the common causes of shellfish allergy that is increasing worldwide. One of the important problems in the management of shellfish allergy is the lack of accurate diagnostic assay because the biological and immunological properties of allergens in black tiger shrimp have not been well characterized. This study aims to detect proteins with the ability to bind and cross-link immunoglobulin E (IgE) from black tiger shrimp by enzyme-linked immunosorbent assay (ELISA), Western blot, and a humanized rat basophilic leukemia reporter cell line RS-ATL8...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29171912/concomitant-sensitization-to-legumin-fag-e-2-and-fag-e-5-predicts-buckwheat-allergy
#16
S Geiselhart, C Nagl, P Dubiela, A C Pedersen, M Bublin, C Radauer, C Bindslev-Jensen, K Hoffmann-Sommergruber, C G Mortz
BACKGROUND: Buckwheat (Fagopyrum esculentum) has become increasingly popular as a healthy food in Europe. However, for sensitized individuals, consumption can cause anaphylactic reactions. The aim of this study was to identify individual well-characterized buckwheat allergens for component resolved diagnosis. METHODS: Patients were selected by positive skin prick test to buckwheat and divided into two groups: (1) sensitized to buckwheat without clinical symptoms and (2) buckwheat allergy...
November 24, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29171882/characterization-of-epitope-specificities-of-reference-antibodies-used-for-the-quantification-of-the-birch-pollen-allergen-bet-v-1
#17
Sébastien Brier, Maxime Le Mignon, Karine Jain, Constance Lebrun, François Peurois, Christine Kellenberger, Véronique Bordas-Le Floch, Laurent Mascarell, Emmanuel Nony, Philippe Moingeon
BACKGROUND: Accurate allergen quantification is needed to document the consistency of allergen extracts used for immunotherapy. Herein, we characterize the epitope specificities of two monoclonal antibodies used in an ELISA for the quantification of the major birch pollen allergen Bet v 1, established as a reference by the BSP090 European project. METHODS: The ability of mAbs 5B4 and 6H4 to recognize Bet v 1 isoforms was addressed by immunochromatography. The capacity of each mAb to compete with patients' IgE for binding to Bet v 1 was measured by ELISA inhibition...
November 24, 2017: Allergy
https://www.readbyqxmd.com/read/29159565/a-comprehensive-review-on-mustard-induced-allergy-and-implications-for-human-health
#18
REVIEW
Akanksha Sharma, Alok K Verma, Rinkesh Kumar Gupta, Neelabh, Premendra D Dwivedi
Mustard is widely used in a variety of foods/food products to enhance the flavor and nutritional value that subsequently raise the risk of hypersensitivity reactions. Mustard allergy has been reported for many years and is increasing gradually especially in the areas where its consumption is comparatively higher, and it may be considered among the most important food allergies. A number of relevant clinical studies focused on mustard-induced allergic manifestations are summarized in the current review. In addition, the knowledge regarding the immunological as well as biochemical characteristics of mustard allergens that have been known till date and their cross-reactivity with other food allergens have also been discussed here...
November 20, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29156294/phospholipase-a1-based-cross-reactivity-among-venoms-of-clinically-relevant-hymenoptera-from-neotropical-and-temperate-regions
#19
Amilcar Perez-Riverol, Luís Gustavo Romani Fernandes, Alexis Musacchio Lasa, José Roberto Aparecido Dos Santos-Pinto, Débora Moitinho Abram, Gabriel Hideki Izuka Moraes, Frederic Jabs, Michaela Miehe, Henning Seismman, Mario Sergio Palma, Ricardo de Lima Zollner, Edzard Spillner, Márcia Regina Brochetto-Braga
Molecular cross-reactivity caused by allergen homology or cross-reactive carbohydrate determinants (CCDs) is a major challenge for diagnosis and immunotherapy of insect venom allergy. Venom phospholipases A1 (PLA1s) are classical, mostly non-glycosylated wasp and ant allergens that provide diagnostic benefit for differentiation of genuine sensitizations from cross-reactivity. As CCD-free molecules, venom PLA1s are not causative for CCD-based cross-reactivity. Little is known however about the protein-based cross-reactivity of PLA1 within vespid species...
November 17, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29132960/influenza-derived-peptides-cross-react-with-allergens-and-provide-asthma-protection
#20
Chrysanthi Skevaki, Christoph Hudemann, Mikhail Matrosovich, Christian Möbs, Sinu Paul, Andreas Wachtendorf, Bilal Alashkar Alhamwe, Daniel P Potaczek, Stefanie Hagner, Diethard Gemsa, Holger Garn, Alessandro Sette, Harald Renz
BACKGROUND: The hygiene hypothesis is the leading concept to explain the current asthma epidemic, which is built on the observation that a lack of bacterial contact early in life induces allergic Th2 immune responses. OBJECTIVE: Since little is known about the contribution of respiratory viruses in this context, we evaluated the effect of prior influenza-infection on the development of allergic asthma. METHODS: Mice were infected with influenza and once recovered, subjected to an ovalbumin or house dust mite-induced experimental asthma protocol...
November 10, 2017: Journal of Allergy and Clinical Immunology
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