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allergen cross-reactivity

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https://www.readbyqxmd.com/read/28925060/current-food-allergenic-risk-assessment-is-it-fit-for-novel-foods-status-quo-and-identification-of-gaps
#1
REVIEW
Gabriel Mazzucchelli, Thomas Holzhauser, Tanja Cirkovic-Velickovic, Araceli Diaz-Perales, Elena Molina, Paola Roncada, Pedro Rodrigues, Kitty Verhoeckx, Karin Hoffmann-Sommergruber
Food allergies are recognised as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well known foods and foods containing genetically modified ingredients was installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources...
September 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28923489/severe-anaphylaxis-due-to-crocodile-meat-allergy-exhibiting-wide-cross-reactivity-with-fish-allergens
#2
Elisa Haroun-Díaz, Natalia Blanca-López, María Vázquez de la Torre, Francisco Javier Ruano, Maria Luisa Somoza Álvarez, Moísés Labrador Horrillo, Borja Bartolomé, Miguel Blanca, Gabriela Canto Díez
No abstract text is available yet for this article.
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28919435/ultrasensitive-and-rapid-immuno-detection-of-human-ige-anti-therapeutic-horse-sera-using-an-electrochemical-immunosensor
#3
Isis C Prado, André L A Souza, David W Provance-Jr, Ricardo J Cassella, Salvatore G De-Simone
Antivenom allergy disease mediated by patient IgE is an important public health care concern. To improve detection of hypersensitive individuals prior to passive antibody therapy, an amperometric immunosensor was developed to detect reactive human IgE. Whole horse IgG3 (hoIgG3) was immobilized onto the surface of carbon or gold screen-printed electrodes through a cross-linking solution of glutaraldehyde on a chitosan film. Sera from persons with a known allergic response to hoIgG3 or non-allergic individuals was applied to the sensor...
September 14, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28904280/food-dependent-exercise-induced-anaphylaxis-due-to-ingestion-of-mikan-citrus-unshiu
#4
Yutaka Tanaka, Marie Sugihara, Shuntaro Tsumagari, Nobue Takamatsu, Kazuyuki Kurihara
A 12-year-old girl was referred to our hospital owing to repeated anaphylactic reactions induced by exercise after meals. Food-dependent exercise-induced anaphylaxis (FDEIAn) was suspected. However, sequential tests of typical foods, including egg, milk, soy, and wheat, in combination with exercise, were all negative.The results of the skin prick test (SPT) for Citrus unshiu and specific IgE test for orange and grapefruit were positive. Although no symptoms were noted after an exercise challenge combined with the ingestion of only Citrus unshiu, an anaphylactic reaction was induced by additional acetyl-salicylic acid...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28873746/white-fruited-strawberry-genotypes-are-not-per-se-hypoallergenic
#5
Katrin Franz-Oberdorf, Bernadette Eberlein, Kathrin Edelmann, Philip Bleicher, Elisabeth Kurze, Dominic Helm, Klaus Olbricht, Ulf Darsow, Johannes Ring, Wilfried Schwab
The strawberry fruit Fra a 1-proteins are homologues of the major birch pollen allergen Bet v 1 and have essential biological functions in pigment formation during fruit ripening. Patients affected by allergy against birch pollen tolerated fruits of a naturally occurring white-fruited F.×ananassa genotype, which showed reduced levels of Fra a 1 proteins along with enzymes of the anthocyanin pigment pathway. We evaluated the cross-reactive allergenic potential of a number of naturally occurring white- and red-fruited strawberry varieties to detect genotypes with low allergenic reactivity, whose fruit might be tolerated by patients with mild allergy...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28870463/efficacy-and-safety-of-4-months-of-sublingual-immunotherapy-with-recombinant-mal-d-1-and-bet-v-1-in-patients-with-birch-pollen-related-apple-allergy
#6
Tamar Kinaciyan, Birgit Nagl, Sandra Faustmann, Florian Frommlet, Stephan Kopp, Martin Wolkersdorfer, Stefan Wöhrl, Katharina Bastl, Hans Huber, Uwe Berger, Barbara Bohle
BACKGROUND: Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult individuals and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy. OBJECTIVE: To compare the safety and efficacy of sublingual immunotherapy (SLIT) with two formulations containing either recombinant (r) Mal d 1 or Bet v 1 on birch pollen-related apple allergy...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28866404/fresh-water-marine-and-terrestrial-cyanobacteria-display-distinct-allergen-characteristics
#7
Naama Lang-Yona, Anna Theresa Kunert, Lothar Vogel, Christopher Johannes Kampf, Iris Bellinghausen, Joachim Saloga, Anne Schink, Kira Ziegler, Kurt Lucas, Detlef Schuppan, Ulrich Pöschl, Bettina Weber, Janine Fröhlich-Nowoisky
During the last decades, global cyanobacteria biomass increased due to climate change as well as industrial usage for production of biofuels and food supplements. Thus, there is a need for thorough characterization of their potential health risks, including allergenicity. We therefore aimed to identify and characterize similarities in allergenic potential of cyanobacteria originating from the major ecological environments. Different cyanobacterial taxa were tested for immunoreactivity with IgE from allergic donors and non-allergic controls using immunoblot and ELISA...
August 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28855606/a-cross-sectional-observational-study-on-allergen-specific-ige-positivity-in-a-southeast-coastal-versus-a-southwest-inland-region-of-china
#8
Guangqiao Zeng, Wenting Luo, Zehong Wu, Ling Li, Peiyan Zheng, Huimin Huang, Nili Wei, Jiaying Luo, Baoqing Sun, Yong Liu
Few studies addressed trans-regional differences in allergen sensitization between areas within a similar latitudinal range but with distinct geomorphological features. We investigated specific IgE (sIgE) positivity to common allergens in populations from two southern China provinces. Using a uniformed protocol, serum samples were collected from 2778 subjects with suspected atopy in coastal Guangdong and inland Yunnan. The overall prevalence of sIgE positivity were 57.8% (95% CI: 56.0%, 59.6%) from Guangdong vs 60...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833127/effects-of-the-maillard-reaction-on-the-immunoreactivity-of-amandin-in-food-matrices
#9
Guneet S Chhabra, Changqi Liu, Mengna Su, Mahesh Venkatachalam, Kenneth H Roux, Shridhar K Sathe
Amandin is the major storage protein and allergen in almond seeds. Foods, containing almonds, subjected to thermal processing typically experience Maillard browning reaction. The resulting destruction of amino groups, protein glycation, and/or denaturation may alter amandin immunoreactivity. Amandin immunoreactivity of variously processed almond containing foods was therefore the focus of the current investigation. Commercial and laboratory prepared foods, including those likely to have been subjected to Maillard browning, were objectively assessed by determining Hunter L(*) , a(*) , b(*) values...
August 23, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28831729/diagnosis-of-allergy-to-mammals-and-fish-cross-reactive-vs-specific-markers
#10
REVIEW
Christiane Hilger, Marianne van Hage, Annette Kuehn
PURPOSE OF REVIEW: Allergen extracts are still widely used in allergy diagnosis as they are regarded as sensitive screening tools despite the fact that they may lack some minor allergens. Another drawback of extracts is their low specificity, which is due to the presence of cross-reactive allergens. Progress in allergen identification has disclosed a number of allergenic molecules of homologous sequence and structure which are present in different animal species. This review summarizes recent advances in mammalian and fish allergen identification and focuses on their clinical relevance...
August 22, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28829832/allergen-homologs-in-the-euroglyphus-maynei-draft-genome
#11
S Dean Rider, Marjorie S Morgan, Larry G Arlian
Euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in humans. It is the source of species-specific allergens as well as allergens that are cross-reactive with the allergens from house dust mites Dermatophagoides farinae and D. pteronyssinus, and the ectoparasitic scabies mite Sarcoptes scabiei. The genomics, proteomics and molecular biology of E. maynei and its allergens have not been as extensively investigated as those of D...
2017: PloS One
https://www.readbyqxmd.com/read/28818076/extensive-protein-hydrolyzation-is-indispensable-to-prevent-ige-mediated-poultry-allergen-recognition-in-dogs-and-cats
#12
Thierry Olivry, Jennifer Bexley, Isabelle Mougeot
BACKGROUND: The central premise for the commercialization of diets with hydrolyzed ingredients is that the small-sized digested peptides would be unable to crosslink allergen-specific IgE at the surface of tissue mast cells and induce their degranulation. Evidence for the validity of this concept to diagnose food allergies in dogs and cats is limited, however. Our objectives were to study the recognition of standard and variably hydrolyzed poultry extracts by sera from dogs and cats with elevated chicken-specific serum IgE...
August 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28804907/allergic-contact-dermatitis-caused-by-isobornyl-acrylate-in-freestyle%C3%A2-libre-a-newly-introduced-glucose-sensor
#13
Anne Herman, Olivier Aerts, Marie Baeck, Magnus Bruze, Christophe De Block, An Goossens, Nils Hamnerius, Sara Huygens, Dominique Maiter, Dominique Tennstedt, Bernard Vandeleene, Martin Mowitz
BACKGROUND: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. OBJECTIVES: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. PATIENTS AND METHODS: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre...
August 14, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28801713/cross-reactivity-profiles-of-legumes-and-tree-nuts-using-the-xmap-%C3%A2-multiplex-food-allergen-detection-assay
#14
Chung Y Cho, Carolyn Oles, William Nowatzke, Kerry Oliver, Eric A E Garber
The homology between proteins in legumes and tree nuts makes it common for individuals with food allergies to be allergic to multiple legumes and tree nuts. This propensity for allergenic and antigenic cross-reactivity means that commonly employed commercial immunodiagnostic assays (e.g., dipsticks) for the detection of food allergens may not always accurately detect, identify, and quantitate legumes and tree nuts unless additional orthogonal analytical methods or secondary measures of analysis are employed...
August 12, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28800704/qualitative-and-quantitative-analysis-of-carbohydrate-modification-on-glycoproteins-from-seeds-of-ginkgo-biloba
#15
Ting Wang, Xiao-Chun Hu, Zhi-Peng Cai, Josef Voglmeir, Li Liu
Recent progress in the relationship between carbohydrate cross-reactive determinants (CCDs) and allergic response highlights the importance of carbohydrate moieties in the innate immune system. Previous research pointed out that the protein allergen in Ginkgo biloba seeds is glycosylated, and the oligosaccharides conjugated to these proteins might also contribute to the allergy. The aim of this study was to analyze carbohydrate moieties, especially N-linked glycans, of glycoproteins from Ginkgo seeds originating from different places for detailed structures, to enable further research on the role played by N-glycans in Ginkgo-caused allergy...
September 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28782634/a-new-allergen-family-involved-in-pollen-food-associated-syndrome-snakin-gibberellin-regulated-proteins
#16
Hélène Sénéchal, Jiří Šantrůček, Magdalena Melčová, Petr Svoboda, Jarmila Zídková, Denis Charpin, Laurence Guilloux, Youcef Shahali, Marie-Ange Selva, Rémy Couderc, Tomoyasu Aizawa, Pascal Poncet
At least two pollen food associated syndromes were described with cypress pollen allergy involving peach and citrus. Snakin/gibberellin regulated proteins are described herein to be the cross-reactive allergens between Cupressus sempervirens pollen and fruit/vegetables.
August 3, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28776709/allergic-contact-dermatitis-caused-by-dimethylthiocarbamylbenzothiazole-sulfide-dmtbs-in-canvas-shoes-in-search-of-the-culprit-allergen
#17
Marie L Schuttelaar, Joost M Meijer, Malin Engfeldt, Hilde Lapeere, An Goossens, Magnus Bruze, Christina Persson, Ola Bergendorff
BACKGROUND: During rubber vulcanization, new compounds can be formed. OBJECTIVES: To report a case of allergic shoe dermatitis in which the search for the allergen ultimately led to the identification of dimethylthiocarbamylbenzothiazole sulfide (DMTBS). METHODS: A female presented with eczema on her feet after wearing Sperry Top Sider® canvas sneakers. Patch testing was performed with the European baseline series, additional series, shoe materials, and extracts of shoe materials...
August 4, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28760720/profilin-a-change-in-the-paradigm
#18
P Rodríguez Del Río, A Díaz-Perales, S Sánchez-García, C Escudero, M D Ibáñez, P Méndez-Brea, D Barber
Profilin is a protein present in all eukaryotic cells, and is responsible for the cross-reactivity between pollen, latex and plant foods. It has been classically acknowledged as a minor or nearly irrelevant allergen, although recent data are changing this conception. The objective of this manuscript is to comprehensively review the published data on the role of this ubiquitous allergen in pollen, latex and plant food allergy. The patterns of recognition of this minor allergen follow a north-south gradient, and although present in all pollens and vegetables, it is significantly associated with grass pollen and Cucurbitaceae fruits...
August 1, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28759475/component-resolved-diagnostics-for-hymenoptera-venom-allergy
#19
Thilo Jakob, Ulrich Müller, Arthur Helbling, Edzard Spillner
PURPOSE OF REVIEW: Component-resolved diagnostics makes use of defined allergen molecules to analyse IgE-mediated sensitizations at a molecular level. Here, we review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. RECENT FINDINGS: Component resolution in HVA has moved from single molecules to panels of allergens. Detection of specific immunoglobulin E (sIgE) to marker and cross-reactive venom allergens has been reported to facilitate the discrimination between primary sensitization and cross-reactivity and thus, to provide a better rationale for prescribing venom immunotherapy (VIT), particularly in patients sensitized to both honeybee and vespid venom...
October 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28729676/proteomic-profiling-of-the-weed-feverfew-a-neglected-pollen-allergen-source
#20
Isabel Pablos, Stephanie Eichhorn, Peter Briza, Claudia Asam, Ulrike Gartner, Martin Wolf, Christof Ebner, Barbara Bohle, Naveen Arora, Stefan Vieths, Fatima Ferreira, Gabriele Gadermaier
Feverfew (Parthenium hysterophorus), an invasive weed from the Asteraceae family, has been reported as allergen source. Despite its relevance, knowledge of allergens is restricted to a partial sequence of a hydroxyproline-rich glycoprotein. We aimed to obtain the entire sequence for recombinant production and characterize feverfew pollen using proteomics and immunological assays. Par h 1, a defensin-proline fusion allergen was obtained by cDNA cloning and recombinantly produced in E. coli. Using two complementary proteomic strategies, a total of 258 proteins were identified in feverfew pollen among those 47 proteins belonging to allergenic families...
July 20, 2017: Scientific Reports
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