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allergen cross-reactivity

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https://www.readbyqxmd.com/read/29756679/effect-of-heat-processing-on-ige-reactivity-and-cross-reactivity-of-tropomyosin-and-other-allergens-of-asia-pacific-mollusc-species-identification-of-novel-sydney-rock-oyster-tropomyosin-sac-g-1
#1
Jennifer M Rolland, Nirupama P Varese, Jodie B Abramovitch, Jessica Anania, Roni Nugraha, Sandip Kamath, Anita Hazard, Andreas L Lopata, Robyn E O'Hehir
SCOPE: Shellfish allergy is an increasing global health priority, frequently affecting adults. Molluscs are an important shellfish group causing food allergy but knowledge of their allergens and cross-reactivity is limited. Optimal diagnosis of mollusc allergy enabling accurate advice on food avoidance is difficult. We characterized allergens of four frequently ingested Asia-Pacific molluscs: Sydney Rock Oyster (Saccostrea glomerata), Blue Mussel (Mytilus edulis), Saucer Scallop (Amusium balloti) and Southern Calamari (Sepioteuthis australis), examining cross-reactivity between species and with Blue Swimmer Crab tropomyosin, Por p 1...
May 14, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29734356/microbiota-epitope-similarity-either-dampens-or-enhances-the-immunogenicity-of-disease-associated-antigenic-epitopes
#2
Sebastian Carrasco Pro, Cecilia S Lindestam Arlehamn, Sandeep K Dhanda, Chelsea Carpenter, Mikaela Lindvall, Ali A Faruqi, Clark A Santee, Harald Renz, John Sidney, Bjoern Peters, Alessandro Sette
The microbiome influences adaptive immunity and molecular mimicry influences T cell reactivity. Here, we evaluated whether the sequence similarity of various antigens to the microbiota dampens or increases immunogenicity of T cell epitopes. Sets of epitopes and control sequences derived from 38 antigenic categories (infectious pathogens, allergens, autoantigens) were retrieved from the Immune Epitope Database (IEDB). Their similarity to microbiome sequences was calculated using the BLOSUM62 matrix. We found that sequence similarity was associated with either dampened (tolerogenic; e...
2018: PloS One
https://www.readbyqxmd.com/read/29732293/skin-prick-test-reactivity-to-aeroallergens-in-adult-allergy-clinic-in-thailand-a-12-year-retrospective-study
#3
Supa Oncham, Umaporn Udomsubpayakul, Wannada Laisuan
Background: The global prevalence of allergic rhinitis, asthma, and atopic dermatitis has risen significantly over the last 2 decades. Allergic sensitization to aeroallergen is a major risk factor in developing the allergic disease. The prevalence of aeroallergen sensitization varies in different regions and countries. Objective: To determine the prevalence of common aeroallergen sensitization and the atopic status among adult patients. Methods: A cross-sectional, retrospective study...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29731166/insect-food-allergy-and-allergens
#4
Steffie de Gier, Kitty Verhoeckx
Insects represent an alternative for meat and fish in satisfying the increasing demand for sustainable sources of nutrition. Approximately two billion people globally consume insects. They are particularly popular in Asia, Latin America, and Africa. Most research on insect allergy has focussed on occupational or inhalation allergy. Research on insect food safety, including allergenicity, is therefore of great importance. The objective of this review is to provide an overview of cases reporting allergy following insect ingestion, studies on food allergy to insects, proteins involved in insect allergy including cross-reactive proteins, and the possibility to alter the allergenic potential of insects by food processing and digestion...
May 3, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29700869/tree-nut-allergies-allergen-homology-cross-reactivity-and-implications-for-therapy
#5
Johanna M Smeekens, Kenneth Bagley, Michael Kulis
Tree nut allergy is a potentially life-threatening disease that is increasing in prevalence, now affecting 1% of the general population in the United States. While other food allergies often resolve spontaneously, tree nut allergies are outgrown in less than 10% of cases. Due to the likelihood of cross-sensitization to multiple tree nut allergens, the current treatment guideline is strict avoidance of all nuts once one tree nut allergy has been diagnosed. For example, walnut and pecan are highly cross-reactive, along with cashew and pistachio, but the extent of clinical, IgE-mediated cross-reactivity among other tree nuts remains unclear, therefore making avoidance of all tree nuts a safe approach...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29692253/advances-in-food-allergy-diagnosis
#6
Alexandra F Santos, Joana Gomes-Belo, Farah Hannachi, Kate Swan
An accurate diagnosis of food allergy is extremely important to guide safe and yet not overly restrictive dietary management. The cornerstone of the diagnosis of food allergy is the clinical history; it allows appropriate selection of the allergens to be tested and interpretation of the results of allergy tests, namely skin prick test (SPT), specific IgE (sIgE) to allergen extracts and, more recently, specific IgE to allergen components and the basophil activation test (BAT). SPT and sIgE to allergen extracts are very sensitive methods to detect IgE sensitization to a specific food...
April 22, 2018: Current Pediatric Reviews
https://www.readbyqxmd.com/read/29666553/the-potential-of-component-resolved-diagnosis-in-laboratory-diagnostics-of-allergy
#7
REVIEW
Slavica Dodig, Ivana Čepelak
The initial laboratory approach in the diagnosis of allergies is to detect the type of allergic reaction, i.e. whether the patient's allergy is mediated by immunoglobulin E (IgE) or not. For this purpose, the concentration of total serum IgE (tIgE) and specific IgE (sIgE) are determined. Progress in laboratory diagnostics is the use of component-resolved diagnosis (CRD) which implies determination of sIgE against purified native and recombinant allergenic molecules. Component-resolved diagnosis is used in laboratory practice as singleplex and multiplex assays...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29627609/distinguishing-allergens-from-non-allergenic-homologues-using-physical-chemical-property-pcp-motifs
#8
Wenzhe Lu, Surendra S Negi, Catherine H Schein, Soheila J Maleki, Barry K Hurlburt, Werner Braun
Quantitative guidelines to distinguish allergenic proteins from related, but non-allergenic ones are urgently needed for regulatory agencies, biotech companies and physicians. In a previous study, we found that allergenic proteins populate a relatively small number of protein families, as characterized by the Pfam database. However, these families also contain non-allergenic proteins, meaning that allergenic determinants must lie within more discrete regions of the sequence. Thus, new methods are needed to discriminate allergenic proteins within those families...
April 5, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29622231/development-of-loop-mediated-isothermal-amplification-lamp-assays-for-the-rapid-detection-of-allergic-peanut-in-processed-food
#9
Shyang-Chwen Sheu, Po-Chuan Tsou, Yi-Yang Lien, Meng-Shiou Lee
Peanut is a widely and common used in many cuisines around the world. However, peanut is also one of the most important food allergen for causing anaphylactic reaction. To prevent allergic reaction, the best way is to avoid the food allergen or food containing allergic ingredient such as peanut before food consuming. Thus, to efficient and precisely detect the allergic ingredient, peanut or related product, is essential and required for maintain consumer's health or their interest. In this study, a loop-mediated isothermal amplification (LAMP) assay was developed for the detection of allergic peanut using specifically designed primer sets...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29606424/lupine-allergen-detecting-capability-and-cross-reactivity-of-related-legumes-by-elisa
#10
Martina Koeberl, Michael F Sharp, Rongkai Tian, Saman Buddhadasa, Dean Clarke, James Roberts
Lupine belongs to the genus Lupinus and includes three species commonly consumed by humans. The Lupinus genus is closely related to other legumes, such as peanuts, soya, chickpeas, peas, lentils and beans. However, the consumption of lupine (and related legumes) can cause severe allergenic reactions. Therefore, reliable analytical detection methods are required for the analysis of food samples. In this study three commercially available ELISA test kits were analyzed for the detection capability of three common lupine species, as well as cross-reactivity to related legumes...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29602574/ige-and-t-cell-responses-to-house-dust-mite-allergen-components
#11
Wayne R Thomas
Using the terminology for Dermatophagoides pteronyssinus, IgE responses to house dust mites have been shown to be mostly directed to the serodominant Der p 1, 2 and 23 allergen components with mid -tier responses to Der p 4, 5, 7 and 21 that are made by 30-50% of subjects with titers proportional to those of the serodominant specificities. This pattern can be seen to evolve in childhood and although responses to minor allergens appear to contribute little to the total IgE they are at least markers for a greater propensity to develop disease...
March 27, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29590653/misleading-allergens-in-the-diagnosis-of-latex-allergy-profilin-and-cross-reactive-carbohydrate-determinants
#12
Feridun Gürlek, Mehmet Ünsel, Ömür Ardeniz, Zeynep Peker Koc, Okan Gülbahar, Aytül Zerrin Sin, Ali Kokuludag, Nihal Mete Gokmen
BACKGROUND: It has been suggested that latex-specific IgE analysis may lead to false-positive results, especially in patients with pollen allergy. In the present study, the reasons underlying clinically irrelevant latex-specific IgE positivity were investigated. METHODS: Thirty patients with latex allergy (group 1), 89 patients sensitised to aeroallergens (group 2a), and 98 healthy individuals without allergy (group 2b) were enrolled. Participants from all 3 groups were subjected to skin prick tests with aeroallergens including latex, latex-specific IgE analysis (ImmunoCAP), and nasal provocation test with latex...
2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29588070/parasite-allergens
#13
Luis Caraballo, Sandra Coronado
Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infections is intriguing that they are not usually associated with allergic symptoms, which probably (but not exclusively) depends on parasite-induced immunomodulation. However, allergic manifestations have been described during some helminth infections such as ascariasis, strongyloidiasis, anisakiasis and hydatidosis...
March 24, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29549697/beta-expansin-of-bermuda-johnson-and-para-grass-pollens-is-a-major-cross-reactive-allergen-for-allergic-rhinitis-patients-in-subtropical-climate
#14
Punchama Pacharn, Wisuwat Songnual, Umaporn Siriwatanakul, Torpong Thongngarm, Onrapak Reamtong, Orathai Jirapongsananuruk, Chawewan Bunnag, Surapon Piboonpocanun
BACKGROUND: Subtropical grass pollens of Bermuda (BGP), Johnson (JGP), and Para or buffalo grass (PGP), are common causes of pollen allergies in warm climate area. Allergic rhinitis (AR) patients had positive skin prick test (SPT) to extract of these 3 grass pollens. However, no allergenic proteins of 3 grass pollens have never been studied. OBJECTIVE: To identify major allergens of BGP, JGP, and PGP in Thai grass pollen-allergic patients and to examine their sIgE cross-reactivity...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29525489/identification-of-cha-o-3-homolog-cry-j-4-from-cryptomeria-japonica-japanese-cedar-pollen-limitation-of-the-present-japanese-cedar-specific-asit
#15
Toshihiro Osada, Yuki Tanaka, Akira Yamada, Eiji Sasaki, Teruhiro Utsugi
BACKGROUND: About one-third of the Japanese population suffers from Japanese cedar pollinosis, which is frequently accompanied by Japanese cypress pollinosis. Recently, a novel major Japanese cypress pollen allergen, Cha o 3, was discovered. However, whether a Cha o 3 homolog is present in Japanese cedar pollen remains to be determined. METHODS: Western blot analysis was performed using Cha o 3-specific antiserum. In addition, cloning of the gene encoding Cry j 4 was conducted using total cDNA from the male flower of Japanese cedar trees...
March 7, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29510117/antigenic-cross-reactivity-between-schistosoma-mansoni-and-pollen-allergens-from-the-birch-tree-betula-verrucosa-and-timothy-grass-phleum-pratense-involvement-of-shared-glycan-epitopes-and-implications-for-the-hygiene-hypothesis
#16
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Gabriele Schramm, Michael J Doenhoff
Previous studies have shown that schistosome infection can protect against allergic symptoms, but the underlying mechanisms are still not fully understood. Here we have shown that rabbit IgG antibodies raised against Schistosoma mansoni soluble egg antigens (SmSEA) are cross-reactive with a wide array of molecules in Timothy grass pollen (TGP) and birch tree pollen (BTP). Five of the cross-reactive pollen molecules (two from TGP and three from BTP) were selected randomly and identified by tandem mass spectrometric (TMS) analysis to be, respectively, the TGP allergens Phl p 1 and Phl p 5b, and BTP glutathione S-transferase (GST), and the BTP allergens Bet v 1 and Bet v 6...
April 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29498135/a-preliminary-study-of-serum-ige-against-cross-reactive-carbohydrate-determinants-ccd-in-client-owned-atopic-dogs
#17
Britt J Levy, Douglas J DeBoer
BACKGROUND: Cross-reactive carbohydrate determinants (CCD) are defined carbohydrate portions of glycoprotein cell surface molecules common to many plant and insect species. Mammalian species recognize CCD as foreign antigens and can mount humoral immune responses against them. Approximately 20-37% of grass and venom allergic people possess circulating IgE against CCD; these antibodies are generally considered clinically irrelevant. Anti-CCD IgE is, however, recognized as a cause of false positive, clinically incongruent serum allergen test results in people; this phenomenon has not been investigated in animals...
March 1, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29391255/an-unexpected-protective-role-of-low-affinity-allergen-specific-igg-through-the-inhibitory-receptor-fc%C3%AE-riib
#18
Lisha Zha, Fabiana M S Leoratti, Lichun He, Mona O Mohsen, Mark Cragg, Federico Storni, Monique Vogel, Martin F Bachmann
BACKGROUND: Induction of allergen-specific IgG antibodies is a critical parameter for successful allergen-specific immunotherapy. IgG antibodies can inhibit IgE-mediated mast cell activation through direct allergen neutralization or through the inhibitory receptor FcγRIIb. The affinity of IgE antibodies to the allergen has been shown to be critical for cellular activation. OBJECTIVE: Here we addressed the question of affinity thresholds of allergen-specific IgG antibodies for inhibition of mast cell activation using 2 different mAbs against the major cat allergen Fel d 1 both in vitro and in vivo in mice...
January 31, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29377469/component-resolved-diagnostics-demonstrates-that-most-peanut-allergic-individuals-could-potentially-introduce-tree-nuts-to-their-diet
#19
R Uotila, A K Kukkonen, W M Blom, B Remington, J Westerhout, A S Pelkonen, M J Mäkelä
BACKGROUND: Nut allergy varies from pollen cross-allergy, to primary severe allergy with life-threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species-specific and cross-reactive allergens, is made possible via microarray analysis. OBJECTIVE: We sought to study the association of variable IgE sensitization profiles to clinical response in peanut-challenged children and adolescents in a birch-endemic region. In addition, we studied the avoidance of tree nuts and species-specific sensitizations...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29369414/molecular-sensitization-patterns-and-influence-of-molecular-diagnosis-in-immunotherapy-prescription-in-children-sensitized-to-both-grass-and-olive-pollen
#20
Ana Martínez-Cañavate Burgos, Javier Torres-Borrego, Ana Belén Molina Terán, Jose Luis Corzo, Blanca Esther Garcia, Ramón Rodríguez Pacheco, Carmen Moreno Aguilar, Ignacio Dávila
BACKGROUND: The overlapping grass and olive pollen seasons in Spain and the phenomenon of cross-reactivity can make it difficult to determine the true causative agent of seasonal allergic rhinitis when only skin prick tests with whole extracts are used. The aim of the GRAMOLE study was to determine sensitization patterns to the major grass and olive pollen allergens detected using specific recombinant IgE and to explore how this knowledge affected physicians' choice of allergen-specific immunotherapy...
January 25, 2018: Pediatric Allergy and Immunology
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