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allergen cross-reactivity

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https://www.readbyqxmd.com/read/29132960/influenza-derived-peptides-cross-react-with-allergens-and-provide-asthma-protection
#1
Chrysanthi Skevaki, Christoph Hudemann, Mikhail Matrosovich, Christian Möbs, Sinu Paul, Andreas Wachtendorf, Bilal Alashkar Alhamwe, Daniel P Potaczek, Stefanie Hagner, Diethard Gemsa, Holger Garn, Alessandro Sette, Harald Renz
BACKGROUND: The hygiene hypothesis is the leading concept to explain the current asthma epidemic, which is built on the observation that a lack of bacterial contact early in life induces allergic Th2 immune responses. OBJECTIVE: Since little is known about the contribution of respiratory viruses in this context, we evaluated the effect of prior influenza-infection on the development of allergic asthma. METHODS: Mice were infected with influenza and once recovered, subjected to an ovalbumin or house dust mite-induced experimental asthma protocol...
November 10, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29130794/allergen-immunotherapy-for-birch-apple-syndrome-what-do-we-know
#2
Cristoforo Incorvaia, Erminia Ridolo, Marina Mauro, Marina Russello, Elide Pastorello
Apple allergy is common in patients allergic to birch pollen, and this is defined as 'birch-apple syndrome'. Allergens responsible for cross-reactivity belong to the pathogenesis-related-10 family, and high homology in the amino acid sequences of the major allergens Bet v 1 from birch and Mal d 1 from apple has been demonstrated. Here we review the literature on the treatment of birch-apple syndrome by allergen immunotherapy. The only allergen immunotherapy method available thus far is based on the administration of birch-pollen extracts, through the subcutaneous or sublingual route, to induce tolerance to Bet v1 and to the homologous allergen Mal d 1...
November 2017: Immunotherapy
https://www.readbyqxmd.com/read/29121407/strong-and-frequent-t-cell-responses-to-the-minor-allergen-phl-p-12-in-spanish-patients-ige-sensitized-to-profilins
#3
Gitte Lund, Stephanie Brand, Tania Ramos, Lucia Jimeno, Patrice Boissy, Francisco Vega, Maria Arina, Lars Harder Christensen, Ilka Hoof, Kåre Hvalsøe Meno, Domingo Barber, Carlos Blanco, Peter Adler Würtzen, Peter Sejer Andersen
BACKGROUND: Profilins are dominant pan-allergens known to cause cross-sensitization, leading to clinical symptoms such as the pollen food syndrome. This study aims to determine the T-cell response to Phl p 12 in profilin-sensitized patients, by measuring the prevalence, strength and cross-reactivity to clinically relevant profilins. METHODS: The release of Phl p allergens from pollen was determined by mass spectrometry and immunochemistry. T-cell responses, epitope mapping and cross-reactivity to profilins (Phl p 12, Ole e 2, Bet v 2, and Mal d 4) were measured in-vitro using PBMCs from 26 Spanish grass allergic donors IgE-sensitized to profilin...
November 9, 2017: Allergy
https://www.readbyqxmd.com/read/29120805/characterization-of-narrow-leaf-lupin-lupinus-angustifolius-l-recombinant-major-allergen-ige-binding-proteins-and-the-natural-%C3%AE-conglutin-counterparts-in-sweet-lupin-seed-species
#4
Jose C Jimenez-Lopez, Rhonda C Foley, Ella Brear, Victoria C Clarke, Elena Lima-Cabello, Jose F Florido, Karam B Singh, Juan D Alché, Penelope M C Smith
β-conglutin has been identified as a major allergen for Lupinus angustifolius seeds. The aim of this study was to evaluate the binding of IgE to five recombinant β-conglutin isoforms (rβ) that we overexpressed and purified and to their natural counterparts in different lupin species and cultivars. Western blotting suggested β-conglutins were the main proteins responsible for the IgE reactivity of the lupin species and cultivars. Newly identified polypeptides from "sweet lupin" may constitute a potential new source of primary or cross-reactive sensitization to lupin, particularly to L...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29120774/a-group-specific-quantitative-real-time-pcr-assay-for-detection-of-crab-a-crustacean-shellfish-allergen-in-complex-food-matrices
#5
Anne C Eischeid, Sarah R Stadig
A real-time PCR assay was developed for detection of crab, a crustacean allergen, in food products. Group-specific primers and probes were developed to detect numerous species of crab. Method validation included tests of detection in complex food matrices, evaluation of commercial food products, and cross-reactivity testing on a wide variety of crustaceans. The method was able to detect several species of crab spiked into complex food matrices at levels ranging from 0.1 to 10(5) parts per million (weight/weight), worked equally well on different platforms, exhibited high specificity for crab over other types of crustaceans, and yielded much higher signals from commercial food products listing crab as an ingredient than from those containing other crustaceans...
April 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29118674/high-frequency-of-ige-sensitization-towards-kiwi-seed-storage-proteins-among-peanut-allergic-individuals-also-reporting-allergy-to-kiwi
#6
Jenny van Odijk, Sigrid Sjölander, Peter Brostedt, Magnus P Borres, Hillevi Englund
Background: IgE sensitization to storage proteins from nuts and seed is often related to severe allergic symptoms. There is a risk of immunological IgE cross-reactivity between storage proteins from different species. The potential clinical implication of such cross-reactivity is that allergens other than the known sensitizer can cause allergic symptoms. Previous studies have suggested that kiwi seed storage proteins may constitute hidden food allergens causing cross-reactive IgE-binding with peanut and other tree nut homologs, thereby mediating a potential risk of causing allergy symptoms among peanut ant tree nut allergic individuals...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29106961/immunological-analysis-of-food-proteins-using-high-performance-thin-layer-chromatography-immunostaining
#7
Lena Morschheuser, Kathrin Mink, Ramona Horst, Constanze Kallinich, Sascha Rohn
The chromatographic analysis of intact proteins is still challenging, especially when biological functions as antigenicity of proteins or peptides are in the focus. Traditional immunoassays provide information about the entirety of antigenic proteins/peptides, e.g., in ELISA assays. On the other hand, when focusing on the investigation of (cross) reactivity of antibodies, Western blot following gel-electrophoresis represents the method of choice. However, gel-electrophoresis is limited by the molecular weight and therefore, not suitable for peptides ≤3kDa or proteins ≥250kDa...
October 20, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29096167/crystal-structure-determination-and-analysis-of-11s-coconut-allergen-cocosin
#8
S Vajravijayan, N Nandhagopal, K Gunasekaran
Allergy is an abnormal immune response against an innocuous target. Food allergy is an adverse reaction caused by common foods most well-known being those involving peanuts. Apart from mono sensitized food allergy, cross-reactivity with other food allergens is also commonly observed. To understand the phenomenon of cross-reactivity related to immune response, three dimensional structures of the allergens and their antigenic epitopes has to be analysed in detail. The X-ray crystal structure of Cocosin, a common 11S food allergen from coconut, has been determined at 2...
October 27, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/29072879/cockroach-is-a-major-cross-reactive-allergen-source-in-shrimp-sensitized-rural-children-in-southern-china
#9
Zhaowei Yang, Jiefeng Zhao, Nili Wei, Mulin Feng, Mo Xian, Xu Shi, Zhenyu Zheng, Qiujuan Su, Gary W K Wong, Jing Li
BACKGROUND: Little is known about the prevalence of food allergy (FA) in China. OBJECTIVE: To investigate the prevalence of FA and its disparity between urban and rural areas in southern China. METHODS: Europrevall questionnaire responses were obtained from 5,542 school-age-children in urban Guangzhou and 5,319 in rural Shaoguan. A case-control study enrolled 190 children with adverse reactions (ARs) after food intake as cases, and 212 controls in Guangzhou; 116 cases and 233 controls in Shaoguan...
October 26, 2017: Allergy
https://www.readbyqxmd.com/read/29065418/characterization-of-a-major-allergen-from-mongolian-oak-quercus-mongolica-a-dominant-species-of-oak-in-korea
#10
June Yong Lee, Misuk Yang, Kyoung Yong Jeong, Da Woon Sim, Jin Hee Park, Kyung Hee Park, Jae-Hyun Lee, Jung-Won Park
BACKGROUND: Oaks are the most common trees in Korean forests, and Mongolian oak, Quercus mongolica, is the dominant species. However, no allergen has been characterized from Mongolian oak. In this study, we tried to characterize a major allergen from Mongolian oak. METHODS: A molecule homologous to pathogenesis-related 10 (PR-10)-like protein, Que m 1, was cloned by RT-PCR. Its recombinant protein, along with Que a 1, an allergen from white oak (Q. alba), was produced...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29046027/-frequency-of-skin-reactivity-to-food-allergens-in-allergic-patients
#11
Heriberto Camero-Martínez, Aída Inés López-García, Daniela Rivero-Yeverino, Chrystopherson Gengyny Caballero-López, Oswaldo Arana-Muñoz, Sergio Papaqui-Tapia, Isabel Cristina Rojas-Méndez, Elizabeth Vázquez-Rojas
BACKGROUND: Food allergy is deemed to have a worldwide prevalence ranging from 2 to 10 %. OBJECTIVE: To determine the frequency of skin reactivity to food allergens by age groups. METHODS: Cross-sectional, descriptive, prolective, observational study. Patients aged from 2 to 64 years with symptoms consistent with allergic disease were included. Skin prick tests were carried out with food allergens. Frequencies and percentages were estimated...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29038898/molecular-and-immunological-characterisation-of-tropomyosin-from-anisakis-pegreffii
#12
Abdouslam Asnoussi, Ibukun E Aibinu, Robin B Gasser, Andreas L Lopata, Peter M Smooker
Tropomyosin (TM) is a major allergen in shellfish, known to cross-react with mite, cockroach and/or some roundworm (nematode) TM. In this study, we aimed to express and purify TM from the parasitic nematode Anisakis pegreffii and also to characterise its cross-reactivity with TM from shellfish. A. pegreffii was isolated from the flathead tiger fish (Neoplatycephalus richardsoni) and characterised using single-strand conformation polymorphism (SSCP)-based sequencing of the first and second internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA...
October 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28992615/contributions-and-future-directions-for-structural-biology-in-the-study-of-allergens
#13
Geoffrey A Mueller
Allergy is defined as an inappropriate immune response to something normally considered harmless. The symptomatic immune response is driven by IgE antibodies directed against allergens. The study of allergens has contributed significantly to our understanding of allergic disease in 3 main areas. First, identifying allergens as the cause of symptoms and developing allergen standards has led to many advances in exposure assessment and patient diagnostics. Second, a biochemical understanding of allergens has suggested a number of hypotheses related to the mechanisms of allergic sensitization...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28960341/distinct-epitope-structures-of-defensin-like-proteins-linked-to-proline-rich-regions-give-rise-to-differences-in-their-allergenic-activity
#14
I Pablos, S Eichhorn, Y Machado, P Briza, A Neunkirchner, B Jahn-Schmid, S Wildner, W T Soh, C Ebner, J-W Park, W F Pickl, N Arora, S Vieths, F Ferreira, G Gadermaier
BACKGROUND: Art v 1, Amb a 4, and Par h 1 are allergenic defensin-polyproline-linked proteins present in mugwort, ragweed, and feverfew pollen, respectively. We aimed to investigate the physicochemical and immunological features underlying the different allergenic capacities of those allergens. METHODS: Recombinant defensin-polyproline-linked proteins were expressed in E. coli and physicochemically characterized in detail regarding identity, secondary structure, and aggregation status...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/28960180/salsola-kali-cross-reacts-extensively-with-salsola-imbricata
#15
M Al-Ahmad, T Rodriguez-Bouza, N Fakim, F Pineda
BACKGROUND: There are no studies on the cross-reactivity between Salsola kali and Salsola imbricata pollens. The main goal is to compare the degree of the cross-reactivity between Salsola kali and Salsola imbricata, and secondly to compare the various common allergen components between Salsola kali and Salsola imbricata. METHODS: Serum from rhinitis patients with or without asthma living in Kuwait presenting with a positive skin test to Salsola kali were obtained...
September 29, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28950267/detection-of-the-peanut-allergens-ara-h-2-and-ara-h-6-in-human-breast-milk-development-of-2-sensitive-and-specific-sandwich-elisa-assays
#16
Frauke Schocker, Alexandra Scharf, Skadi Kull, Uta Jappe
BACKGROUND: Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. METHODS: For the quantification of the marker allergens Ara h 2 and Ara h 6 in the low nanogram per milliliter range in breast milk samples of a German cohort, sensitive and highly specific sandwich ELISAs were optimized and validated...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28944625/allergy-to-peanut-soybean-and-other-legumes-recent-advances-in-allergen-characterization-stability-to-processing-and-ige-cross-reactivity
#17
REVIEW
Beatriz Cabanillas, Uta Jappe, Natalija Novak
Peanut and soybean are members of the Leguminosae family. They are two of the eight foods that account for the most significant food allergies in the US and Europe. Allergic reactions to other legume species can be of importance in other regions of the world. The major allergens from peanut and soybean have been extensively analyzed and members of new protein families identified as potential marker allergens for symptom severity. Important recent advances concerning their molecular properties or clinical relevance have been made...
September 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28925060/current-food-allergenic-risk-assessment-is-it-fit-for-novel-foods-status-quo-and-identification-of-gaps
#18
REVIEW
Gabriel Mazzucchelli, Thomas Holzhauser, Tanja Cirkovic-Velickovic, Araceli Diaz-Perales, Elena Molina, Paola Roncada, Pedro Rodrigues, Kitty Verhoeckx, Karin Hoffmann-Sommergruber
Food allergies are recognised as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well known foods and foods containing genetically modified ingredients was installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources...
September 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28923489/severe-anaphylaxis-due-to-crocodile-meat-allergy-exhibiting-wide-cross-reactivity-with-fish-allergens
#19
Elisa Haroun-Díaz, Natalia Blanca-López, María Vázquez de la Torre, Francisco Javier Ruano, Maria Luisa Somoza Álvarez, Moísés Labrador Horrillo, Borja Bartolomé, Miguel Blanca, Gabriela Canto Díez
No abstract text is available yet for this article.
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28919435/ultrasensitive-and-rapid-immuno-detection-of-human-ige-anti-therapeutic-horse-sera-using-an-electrochemical-immunosensor
#20
Isis C Prado, André L A Souza, David W Provance-Jr, Ricardo J Cassella, Salvatore G De-Simone
Antivenom allergy disease mediated by patient IgE is an important public health care concern. To improve detection of hypersensitive individuals prior to passive antibody therapy, an amperometric immunosensor was developed to detect reactive human IgE. Whole horse IgG3 (hoIgG3) was immobilized onto the surface of carbon or gold screen-printed electrodes through a cross-linking solution of glutaraldehyde on a chitosan film. Sera from persons with a known allergic response to hoIgG3 or non-allergic individuals was applied to the sensor...
September 14, 2017: Analytical Biochemistry
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