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allergen cross-reactivity

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https://www.readbyqxmd.com/read/28511284/non-mix-fragrances-are-top-sensitizers-in-consecutive-dermatitis-patients%C3%A2-%C3%A2-a-cross-sectional-study-of-the-26-eu-labelled-fragrance-allergens
#1
Niels H Bennike, Claus Zachariae, Jeanne D Johansen
BACKGROUND: For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene (Lim-OOH)] and oxidized linalool [hydroperoxides of linalool (Lin-OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients. OBJECTIVES: To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II...
May 16, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28506851/immunocap-cellulose-displays-cross-reactive-carbohydrate-ccd-epitopes-and-can-cause-false-positive-test-results-in-patients-with-high-anti-ccd-ige-antibody-levels
#2
Wolfgang Hemmer, Friedrich Altmann, Friedrich Holzweber, Clemens Gruber, Felix Wantke, Stefan Wöhrl
RATIONALE: Cross-reactive carbohydrate determinants (CCDs) in plants and insect venoms are a common cause of irrelevant positive test results during in-vitro allergy diagnosis. We observed that some CCD-positive sera show non-specific IgE-binding even with CCD-free recombinant allergens when using the Phadia ImmunoCAP platform. OBJECTIVE: We investigated if cellulose used as allergen carrier in the ImmunoCAP harbors residual N-glycans causing non-specific background-binding in CCD-positive sera...
May 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28503403/diagnostics-in-hymenoptera-venom-allergy-current-concepts-and-developments-with-special-focus-on-molecular-allergy-diagnostics
#3
Thilo Jakob, David Rafei-Shamsabadi, Edzard Spillner, Sabine Müller
BACKGROUND: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28502519/-blomia-tropicalis-a-house-dust-mite-in-the-tropics
#4
REVIEW
L Guilleminault, C Viala-Gastan
INTRODUCTION: Blomia tropicalis is a mite that belongs to the superfamily of Glycyphagidae. Initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas. STATE OF THE ART: Sensitization to this mite is very common in South America and Southeast Asia. Epidemiological studies have also found sensitization to this mite in Africa and Central America. Blo t 5 is the major allergen of B. tropicalis. Co-sensitization to other house dust mites such as Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) is very common...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28501976/component-resolved-diagnosis-in-hymenoptera-anaphylaxis
#5
REVIEW
D Tomsitz, K Brockow
PURPOSE OF REVIEW: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. RECENT FINDINGS: Many new insect venom allergens have been identified within the last few years...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28500661/is-mealworm-or-shrimp-allergy-indicative-for-food-allergy-to-insects
#6
Henrike Chp Broekman, André C Knulst, Govardus de Jong, Marco Gaspari, Constance F den Hartog Jager, Geert F Houben, Kitty Cm Verhoeckx
SCOPE: The growing world population is a key driver for the exploration of sustainable protein sources to ensure food security. Mealworm and other insects are promising candidates. Previously we found that shrimp allergic patients are at risk for mealworm allergy, and that mealworm can induce a primary allergy 3.This study set out to investigate the allergenic potential of edible insects, suggested for human consumption by agencies such as WHO/FAO, in both the shrimp (potentially cross-reactive) and primary mealworm allergic population...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28485877/diagnostic-precision-of-component-resolved-vs-extract-based-in-vitro-diagnosis-of-hymenoptera-venom-allergy-effects-on-clinical-management
#7
Florian Seyfarth, Diana Miguel, Sibylle Schliemann, Uta-Christina Hipler
BACKGROUND: The measurement of specific IgE (sIgE) antibodies plays a key role in the diagnosis of honeybee and wasp venom allergy. In recent years, component-resolved diagnosis (CRD) has been introduced, which allows for the measurement of sIgE antibodies against Api m 1, Ves v 1, Ves v 5, and Pol d 5, as well as cross-reactive carbohydrate determinants (CCDs). These tests are intended to help determine the clinical relevance of any given sensitization, especially in patients with dual sensitization...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28479330/glycans-and-glycan-specific-ige-in-clinical-and-molecular-allergology-sensitization-diagnostics-and-clinical-symptoms
#8
Arne Homann, Gabriele Schramm, Uta Jappe
Glycan-specific IgE antibodies are cross-reacting with highly similar or even identical carbohydrate structures on a variety of different natural allergens, the so-called cross-reactive carbohydrate determinants (CCDs). In clinical practice, CCDs often interfere with the specificity of in vitro allergy diagnostics, thus impairing allergy therapy decisions for individual patients. Strikingly, these IgE antibodies directed against CCD often do not cause clinically relevant allergy symptoms. Opposed to that, the IgE-binding glycan allergen galactose-α-(1,3)-galactose (α-Gal) is associated with IgE-mediated delayed anaphylaxis in meat allergy...
May 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28478921/mucosal-and-systemic-immune-response-to-sublingual-or-intranasal-immunization-with-phosphorylcholine
#9
Yoshiko Maseda, Junichiro Ohori, Norimitsu Tanaka, Hiromi Nagano, Keiichi Miyashita, Yuichi Kurono
OBJECTIVE: Phosphorylcholine (PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. Here, the immune response in mice to PC immunization via the sublingual (SL) route versus the intranasal (IN) route was investigated in terms of efficacy and safety. METHODS: BALB/c mice were immunized with PC-keyhole limpet hemocyanin (KLH) plus cholera toxin (CT) or CT alone via the IN or SL route. The immune response generated was studied in terms of PC-specific antibody titers, interferon (IFN)-γ and interleukin (IL)-4 production by CD4(+) T cells, and cross-reactivity of PC-specific immunoglobulin (Ig)-A antibodies in nasal washes against S...
May 4, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28467993/recombinant-allergens-in-structural-biology-diagnosis-and-immunotherapy
#10
Angelika Tscheppe, Heimo Breiteneder
The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible...
May 4, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28464293/amb-a-1-isoforms-unequal-siblings-with-distinct-immunological-features
#11
Martin Wolf, Teresa E Twaroch, Sara Huber, Manuel Reithofer, Markus Steiner, Lorenz Aglas, Michael Hauser, Iris Aloisi, Claudia Asam, Heidi Hofer, Maria A Parigiani, Christof Ebner, Barbara Bohle, Peter Briza, Neubauer Angela, Frank Stolz, Beatrice Jahn-Schmid, Michael Wallner, Fatima Ferreira
BACKGROUND: Ragweed pollen represents a major allergy risk factor. Ragweed extracts contain five different isoforms of the major allergen Amb a 1. However, the immunologic characteristics of Amb a 1 isoforms are not fully investigated. Here we compared the physicochemical and immunological properties of three most important Amb a 1 isoforms. METHODS: After purification, the isoforms were physicochemically characterized, tested for antibody-binding and induction of human T cell proliferative responses...
May 2, 2017: Allergy
https://www.readbyqxmd.com/read/28439939/identification-of-a-polygalacturonase-cup-s-2-as-the-major-ccd-bearing-allergen-in-cupressus-sempervirens-pollen
#12
Youcef Shahali, Jean-Pierre Sutra, Christiane Hilger, Kyria Swiontek, Iman Haddad, Joelle Vinh, Laurence Guilloux, Denis Charpin, Hélène Sénéchal, Pascal Poncet
Since IgE glyco-epitopes, also referred to as cross-reactive carbohydrate determinants (CCDs), can share significant structural homologies between different plants, they are prone to extensive cross-reactivity among allergen pollen extracts. Here, cypress pollen allergens, especially a polygalacturonase (PG), were further characterized using double one dimensional electrophoresis (D1-DE). The presence of specific IgE directed against CCDs was investigated by bromelain IgE inhibition and concanavalin A binding assays using sera of cypress pollen sensitized patients...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28439905/der-f-35-an-md-2-like-house-dust-mite-allergen-that-cross-reacts-with-der-f-2-and-pso-o-2
#13
Takashi Fujimura, Tsunehiro Aki, Toshihide Isobe, Akito Matsuoka, Takaharu Hayashi, Kazuhisa Ono, Seiji Kawamoto
BACKGROUND: Dermatophagoides farinae is a source of airborne house dust mite (HDM) allergens. We elucidated IgE-reactive allergens from D. farinae by two-dimensional immunoblotting-based allergenome analysis, and identified one new allergen, named Der f 35, that possesses IgE-binding capacity comparable to that of Der f 2. The aim of this study is to clarify the allergenic capacity of new HDM allergen Der f 35. METHODS: We cloned der f 35 from D. farinae mRNA and produced recombinant Der f 35 in Escherichia coli...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28434865/allergens-involved-in-the-cross-reactivity-of-aedes-aegypti-with-other-arthropods
#14
Jose Fernando Cantillo, Leonardo Puerta, Sylvie Lafosse-Marin, Jose Luis Subiza, Luis Caraballo, Enrique Fernandez-Caldas
BACKGROUND: Cross-reactivity between Aedes aegypti and mites, cockroaches, and shrimp has been previously suggested, but the involved molecular components have not been fully described. OBJECTIVE: To evaluate the cross-reactivity between A aegypti and other arthropods. METHODS: Thirty-four serum samples from patients with asthma and/or allergic rhinitis were selected, and specific IgE to A aegypti, Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis, Periplaneta americana...
April 20, 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28401436/cypress-pollinosis-from-tree-to-clinic
#15
REVIEW
Denis Charpin, Christian Pichot, Jordina Belmonte, Jean-Pierre Sutra, Jarmila Zidkova, Pascal Chanez, Youcef Shahali, Hélène Sénéchal, Pascal Poncet
Cypress (Cupressus sp.pl) is a genus within the Cupressaceae family. This family covers all of the Earth's continents except for Antarctica, and it includes about 160 species. The most important taxa for allergic diseases belong to five different genera: Cupressus, Hesperocyparis, Juniperus, Cryptomeria, and Chamaecyparis. Cupressaceae species share a common pollen type that can even include the genus Taxus (Taxaceae) when this plant is also present. As Juniperus oxycedrus pollinates in October, Cupressus sempervirens in January and February, Hesperocyparis arizonica (prev...
April 11, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/28331111/longitudinal-monitoring-of-tree-airborne-pollen-in-japan
#16
Reiko Kishikawa, Eiko Kotoh, Chie Oshikawa, Nobuo Soh, Terufumi Shimoda, Akemi Saito, Norio Sahashi, Tadao Enomoto, Atsushi Usami, Hidetoyo Teranishi, Yohko Fujisaki, Toshitaka Yokoyama, Kohji Murayama, Tohru Imai, Yuma Fukutomi, Masami Taniguchi, Tomoaki Iwanaga
RATIONAL: In Japan patients with Japanese Cedar (JC) pollinosis have increased nation widely since the latter of 1970's. The Ministry of Health and Welfare of Japanese Governments has begun to take preventive measures against JC pollinosis and airborne pollen monitoring has begun to investigate as a causative agent since 1986. We have estimated the longitudinal investigation result for successful prevention and treatment against pollinosis in Japan. METHOD: We have monitored airborne pollen all year around since July 1986 by gravitational pollen sampler, Durham's sampler, at more than 20 locations in the Japanese Islands...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28315224/an-overview-of-bioinformatics-tools-and-resources-in-allergy
#17
Zhiyan Fu, Jing Lin
The rapidly increasing number of characterized allergens has created huge demands for advanced information storage, retrieval, and analysis. Bioinformatics and machine learning approaches provide useful tools for the study of allergens and epitopes prediction, which greatly complement traditional laboratory techniques. The specific applications mainly include identification of B- and T-cell epitopes, and assessment of allergenicity and cross-reactivity. In order to facilitate the work of clinical and basic researchers who are not familiar with bioinformatics, we review in this chapter the most important databases, bioinformatic tools, and methods with relevance to the study of allergens...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28275203/anaphylactic-reactions-to-novel-foods-case-report-of-a-child-with-severe-crocodile-meat-allergy
#18
Natalia Ballardini, Anna Nopp, Carl Hamsten, Mirja Vetander, Erik Melén, Caroline Nilsson, Markus Ollert, Carsten Flohr, Annette Kuehn, Marianne van Hage
Availability of "exotic" foods is steadily increasing. In this report, we describe the first case of anaphylaxis to crocodile meat. The patient was a 13-year-old boy with severe immunoglobulin E-mediated allergy to chicken meat. When tasting crocodile meat for the first time, he developed an anaphylactic reaction. Cross-reactivity between chicken and crocodile meat was suspected to have triggered this reaction. Basophil activation and immunoglobulin E testing confirmed the boy's allergic reaction to crocodile meat proteins...
March 8, 2017: Pediatrics
https://www.readbyqxmd.com/read/28261576/personalized-medicine-in-allergic-asthma-at-the-crossroads-of-allergen-immunotherapy-and-biologicals
#19
REVIEW
Benedikt Fritzsching
Major allergic disease can be viewed as clinical syndromes rather than discrete disease entities. Emerging evidence indicates that allergic asthma includes several disease phenotypes. Immunological deviation toward high T helper cell type 2 cytokine levels has been demonstrated for a subgroup of pediatric asthma patients, and now, several novel monoclonal antibodies have been approved for treatment of this subgroup as a stratified approach of "personalized" medicine in allergy. Introduction of component-based IgE testing before allergen immunotherapy (AIT), i...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28261033/allergy-to-grass-pollen-mapping-of-dactylis-glomerata-and-phleum-pratense-allergens-for-dogs-by-two-dimensional-immunoblotting
#20
Luís Miguel Lourenço Martins, Andreia Grilo Marques, Luísa Maria Dotti Silva Pereira, Saul José Semião-Santos, Ofélia Pereira Bento
INTRODUCTION: Much less is known about grass-pollen allergens to dogs, when compared with humans. Genetic-based patterns might play an important role in sensitization profiles, conditioning the success of allergen-specific immunotherapy. AIM: Mapping of Dactylis glomerata (D. glomerata) and Phleum pratense (P. pratense) allergens for grass pollen-sensitized atopic dogs, for better understanding how individual allergograms may influence the response to grass-pollen immunotherapy...
February 2017: Postȩpy Dermatologii i Alergologii
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