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allergen cross-reactivity

M A López-Matas, R Moya, V Cardona, A Valero, P Gaig, A Malet, M Viñas, A García-Moral, M Labrador, E Alcoceba, M Ibero, J Carnés
BACKGROUND AND OBJECTIVES: The homologous group of sweet grasses belongs to the Pooideae subfamily, but grass pollen species from other subfamilies can also cause allergy, such as Cynodon dactylon (Chloridoideae) and Phragmites communis (Arundinoideae). C dactylon and P communis have not been included in the sweet grasses homologous group because of their low cross-reactivity with other grasses. The aims of this study were to investigate the profile of sensitization to C dactylon and P communis in patients sensitized to grasses and to analyze cross-reactivity between these 2 species and temperate grasses...
October 2016: Journal of Investigational Allergology & Clinical Immunology
Teresa Stemeseder, Eva Klinglmayr, Stephanie Moser, Lisa Lueftenegger, Roland Lang, Martin Himly, Gertie J Oostingh, Joerg Zumbach, Arne C Bathke, Thomas Hawranek, Gabriele Gadermaier
BACKGROUND: Allergen specific IgE antibodies are a hallmark of type I allergy. The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis. METHODS: Serum samples of 501 non-selected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC(®) for IgE reactivity to 112 single allergens. Sensitization profiles were assessed and statistically coordinated with reported allergies...
October 18, 2016: Allergy
M N Kim, K E Lee, J Y Hong, K W Kim, K-E Kim, M H Sohn, J W Park
BACKGROUND: Peanut allergies are common and can be life-threating for sensitised individuals. Peanut allergens share significant amino acid homology with those of other legumes and tree nuts, but their cross-reactivity still remains unclear. OBJECTIVE: We sought to determine the clinical significance of the cross-reactivity of peanut allergens with those of walnut and soybean. METHODS: Pooled sera from eight subjects with both peanut and walnut specific IgE were investigated in an inhibition test...
October 7, 2016: Allergologia et Immunopathologia
Harold S Nelson
The majority of allergic subjects are polysensitized. In Europe, allergy immunotherapy (AIT) in these patients is usually limited to their single clinically most troublesome allergy while in the U.S. the immunotherapy prescription usually includes all allergen extracts to which the patient has evidence of clinical sensitivity. Areas covered: This article will review the evidence supporting the U.S. practice. It will also review the major new development in the management of polysensitized patients, the introduction of component-resolved diagnosis (CRD)...
October 6, 2016: Expert Review of Clinical Pharmacology
Wenting Luo, Huimin Huang, Peiyan Zheng, Nili Wei, Jiaying Luo, Baoqing Sun, Guangqiao Zeng
There is so far a paucity of data about allergen component-resolved diagnosis, and the prevalence of grass pollen allergen components in China, in contrast to those from western countries. Even in this country, allergies to grass pollen allergen components in the vast south are inadequately described. This study aimed to determine the major sensitizing grass pollens in Guangzhou, the largest city in Guangdong province of southern China. Included in this study were 258 patients having allergic rhinitis with or without asthma and 88 healthy controls...
October 2016: Molecular Immunology
Bronwyn Campbell, Helder Cortes, Giada Annoscia, Alessio Giannelli, Antonio Parisi, Maria Stefania Latrofa, Filipe Dantas-Torres, Luís Cardoso, Domenico Otranto
BACKGROUND: Of increasing importance to the medical and veterinary communities is the zoonotic filarioid nematode Onchocerca lupi. Onchocercosis, thus far found in wolves, dogs, cats and humans, is diagnosed via skin snips to detect microfilariae and surgical removal of adults from the eye of the host. These methods are time-consuming, laborious and invasive, highlighting the need for new tools for the diagnosis of O. lupi in susceptible hosts. Symptoms related to the presence of the adults in the eye can range from none apparent to severe, including blindness...
2016: Parasites & Vectors
Wayne R Thomas
PURPOSE OF REVIEW: Recent findings on house dust allergens and their contribution to knowledge that will significantly impact on current and future allergy treatments are appraised. RECENT FINDINGS: Quantitation of IgE binding to a spectrum of allergen components in several independent studies in varying locations has largely affirmed the main components as the groups 1 and 2 and possibly 23 allergens with mid-tier contributions from the groups 4, 5, 7, and 21. Prevalent binding to Der p 23 has been recapitulated sometimes with low titers...
September 2016: Current Allergy and Asthma Reports
Reto Crameri
It is not common that a Brief Communication is chosen for an Editorial; however, the work presented by Offermann et al. (1) deserves to be commented. Obviously the in vitro diagnosis of allergic sensitisation is based on the determination of soluble allergen-specific IgE in serum (2). Although the correlation between sIgE and allergic sensitization might be disturbed by the presence of clinically irrelevant cross-reactive carbohydrate determinants (3), in most cases allergen-specific IgE in serum can be correlated with the symptomatic (4)...
September 3, 2016: Allergy
Ine I Decuyper, Athina L Van Gasse, Nathalie Cop, Vito Sabato, Margaretha Faber, Christel Mertens, Chris H Bridts, Margo M Hagendorens, Luc De Clerck, H P Rihs, Didier G Ebo
IgE-mediated Cannabis (C. sativa, marihuana) allergy seems to be on the rise. Both active and passive exposure to cannabis allergens may trigger a C. sativa sensitization and/or allergy. The clinical presentation of a C. sativa allergy varies from mild to life-threatening reactions and often seems to depend on the route of exposure. In addition, sensitization to cannabis allergens can result in various cross-allergies, mostly for plant foods. This clinical entity, designated as the "cannabis-fruit/vegetable syndrome" might also imply cross-reactivity with tobacco, natural latex and plant-food derived alcoholic beverages...
September 3, 2016: Allergy
Florian Wölbing, Julia Kunz, Wolfgang Eberhard Kempf, Cornelia Grimmel, Jörg Fischer, Tilo Biedermann
BACKGROUND: Overlapping seasons and cross reactivity, especially to grass pollen profilin, can hamper the diagnosis of birch pollen allergy. To identify the primary sensitizing allergen and the clinical relevance of cross sensitization, we correlated sensitization profiles with in vitro and in vivo tests, symptom scores and pollen counts. METHODS: 433 patients with positive skin prick test (SPT) to birch pollen were analyzed regarding IgE to major birch and grass pollen allergens Bet v 1 and Phl p 1/p 5 and the profilins Bet v 2 and Phl p 12...
September 2, 2016: Allergy
Israel Mares-Mejía, Siseth Martínez-Caballero, Claudia Garay-Canales, Patricia Cano-Sánchez, Alfredo Torres-Larios, Samuel Lara-González, Enrique Ortega, Adela Rodríguez-Romero
Oligomerization of allergens plays an important role in IgE-mediated reactions, as effective crosslinking of IgE- FcεRI complexes on the cell membrane is dependent on the number of exposed B-cell epitopes in a single allergen molecule or on the occurrence of identical epitopes in a symmetrical arrangement. Few studies have attempted to experimentally demonstrate the connection between allergen dimerization and the ability to trigger allergic reactions. Here we studied plant allergenic profilins rHev b 8 (rubber tree) and rZea m 12 (maize) because they represent an important example of cross-reactivity in the latex-pollen-food syndrome...
2016: Scientific Reports
Kyung Hee Park, Young Woong Son, Sang Chul Lee, Kyunguk Jeong, Da Woon Sim, Hye Jung Park, Sooyoung Lee, Jae Hyun Lee, Jung Won Park
PURPOSE: Clinical features of peanut allergy can range from localized to systemic reactions. Because peanut and birch pollen have cross-reactivity, peanut can lead to localized allergic reaction in Fagales pollen-sensitized oral allergy syndrome (OAS) patients without peanut sensitization per se. The purpose of this study was to discriminate true peanut food allergy from cross-reactive hypersensitivity in birch-sensitized peanut allergy. METHODS: Birch-sensitized (n=81) and peanut anaphylaxis patients (n=12) were enrolled...
November 2016: Allergy, Asthma & Immunology Research
Tatiana A Vogel, Rakita W Heijnen, Pieter-Jan Coenraads, Marie-Louise A Schuttelaar
BACKGROUND: Cross-reactions and co-sensitizations are of great importance in understanding contact allergy and exposure sources. OBJECTIVES: To investigate common cross-reactions and co-sensitizations in p-phenylenediamine (PPD)-sensitized and toluene-2,5-diamine (TDA)-sensitized individuals. METHODS: From our patch test population, 8036 patients patch tested with the European baseline series were extracted. Readings had to be performed at least on day 3 according to ICDRG guidelines...
August 24, 2016: Contact Dermatitis
Yvonne Resch, Katharina Blatt, Ursula Malkus, Christian Fercher, Ines Swoboda, Margit Focke-Tejkl, Kuan-Wei Chen, Susanne Seiberler, Irene Mittermann, Christian Lupinek, Azahara Rodriguez-Dominguez, Petra Zieglmayer, René Zieglmayer, Walter Keller, Vladislav Krzyzanek, Peter Valent, Rudolf Valenta, Susanne Vrtala
BACKGROUND: The house dust mite (HDM) allergen Der p 18 belongs to the glycoside hydrolase family 18 chitinases. The relevance of Der p 18 for house dust mite allergic patients has only been partly investigated. OBJECTIVE: To perform a detailed characterization of Der p 18 on a molecular, structural and immunological level. METHODS: Der p 18 was expressed in E. coli, purified to homogeneity, tested for chitin-binding activity and its secondary structure was analyzed by circular dichroism...
2016: PloS One
Magnus P Borres, Nobuyuki Maruyama, Sakura Sato, Motohiro Ebisawa
Due to the high prevalence of food allergic diseases globally there are increasing demands in clinical practice for managing IgE-mediated conditions. During the last decade, component resolved diagnostics has been introduced into the field of clinical allergology, providing information that cannot be obtained from extract-based tests. Component resolved data facilitate more precise diagnosis of allergic diseases and identify sensitizations attributable to cross-reactivity. Furthermore it assists risk assessment in clinical practice as sensitization to some allergenic molecules is related to persistence of clinical symptoms and systemic rather than local reactions...
October 2016: Allergology International: Official Journal of the Japanese Society of Allergology
Kareem Gamal ElRamlawy, Takashi Fujimura, Koji Baba, Ji Won Kim, Chika Kawamoto, Toshihide Isobe, Takuya Abe, Kelsey Hodge-Hanson, Diana M Downs, Inas Hussein Refaat, Diaa Beshr Al-Azhary, Tsunehiro Aki, Yoshiko Asaoku, Takaharu Hayashi, Takashi Katsutani, Shinji Tsuboi, Kazuhisa Ono, Seiji Kawamoto
(HDM) allergy is a growing health problem worldwide, and the characterization of clinically important HDM allergens is a prerequisite for the development of diagnostic and therapeutic strategies. Here, we report a novel HDM allergen that belongs structurally to the highly conserved Rid/YjgF/YER057c/UK114 family (Rid family) with imine deaminase activity. Isolated HDM cDNA, named der f 34, encodes 128 amino acids homologous to Rid-like proteins. This new protein belongs to the Rid family and has seven conserved residues involved in enamine/imine deaminase activity...
August 18, 2016: Journal of Biological Chemistry
Rachel Tham, Don Vicendese, Shyamali Dharmage, Rob J Hyndman, Ed Newbigin, Emma Lewis, Molly O'Sullivan, Adrian J Lowe, Philip Taylor, Philip Bardin, Mimi L K Tang, Michael J Abramson, Bircan Erbas
BACKGROUND: Childhood asthma is a significant public health problem and severe exacerbations can result in diminished quality of life and hospitalisation. OBJECTIVE: To examine the contribution of outdoor fungi to childhood and adolescent asthma hospitalisations. METHODS: The Melbourne Air Pollen Children and Adolescent (MAPCAH) study is a case-crossover study of 644 children and adolescents (aged 2-17 years) hospitalised for asthma. MAPCAH collected individual data on human rhinovirus (HRV) infection and sensitisation to Alternaria and Cladosporium; and daily counts of ambient concentrations of fungal spores, pollen and air pollutants...
August 11, 2016: Journal of Allergy and Clinical Immunology
Mehmet Parlak, Aytekin Çikman, Yasemin Bayram, Nesrin Ceylan, Ulaş Çalişir, Mustafa Berktaş
BACKGROUND/AIM: The purpose of this study was to determine the most frequent food and inhalant allergens leading to allergic sensitization in children in Van Province of Turkey. MATERIALS AND METHODS: The study included 1052 serum samples with no diagnosis of allergy. The sera were tested with the Euroline Pediatric IgE test kit (EUROIMMUN, Germany). By using the EUROLineScan digital evaluation system, the intensity of bands was calculated with enzyme allergosorbent test classification...
2016: Turkish Journal of Medical Sciences
M Schiener, B Eberlein, C Moreno-Aguilar, G Pietsch, P Serrano, M McIntyre, L Schwarze, D Russkamp, T Biedermann, E Spillner, U Darsow, M Ollert, C B Schmidt-Weber, S Blank
BACKGROUND: Hymenoptera stings can cause severe anaphylaxis in untreated venom-allergic patients. A correct diagnosis regarding the relevant species for immunotherapy is often hampered by clinically irrelevant cross-reactivity. In vespid venom allergy, cross-reactivity between venoms of different species can be a diagnostic challenge. To address immunological IgE cross-reactivity on molecular level, seven recombinant antigens 5 of the most important Vespoidea groups were assessed by different diagnostic setups...
August 6, 2016: Allergy
Annice Heratizadeh
PURPOSE OF REVIEW: Atopic dermatitis is a chronic relapsing inflammatory skin disease. In the presence of a complex genetic background, there is increasing evidence for the role of specific allergenic trigger factors in perpetuating skin inflammation in sensitized atopic dermatitis patients. In this review, clinical and in-vitro data so far published on allergen-induced adaptive immune responses in atopic dermatitis are summarized. RECENT FINDINGS: Emerging new data have been published particularly on adaptive immune responses to inhalant allergens in atopic dermatitis...
October 2016: Current Opinion in Allergy and Clinical Immunology
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