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allergen cross-reactivity

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https://www.readbyqxmd.com/read/28643898/identification-of-cross-reactive-b-cell-epitopes-between-bos-d-9-0101-bos-taurus-and-gly-m-5-0101-glycine-max-by-epitope-mapping-maldi-tof-ms
#1
Ángela María Candreva, Mario Ferrer-Navarro, Silvia Bronsoms, Alejandra Quiroga, Renata Curciarello, Ana Cauerhff, Silvana Petruccelli, Guillermo Horacio Docena, Sebastián Alejandro Trejo
Exposure to cow's milk constitutes one of the most common causes of food allergy. In addition, exposure to soy proteins has become relevant in a restricted proportion of milk allergic pediatric patients treated with soy formulae as a dairy substitute, because of the cross-allergenicity described between soy and milk proteins . We have previously identified several cross-reactive allergens between milk and soy that may explain this intolerance. The purpose of the present work was to identify epitopes in the purified αS1-casein and the recombinant soy allergen Gly m 5...
June 23, 2017: Proteomics
https://www.readbyqxmd.com/read/28632196/drug-hypersensitivity-and-desensitizations-mechanisms-and-new-approaches
#2
REVIEW
Leticia de Las Vecillas Sánchez, Leila A Alenazy, Marlene Garcia-Neuer, Mariana C Castells
Drug hypersensitivity reactions (HSRs) are increasing in the 21st Century with the ever expanding availability of new therapeutic agents. Patients with cancer, chronic inflammatory diseases, cystic fibrosis, or diabetes can become allergic to their first line therapy after repeated exposures or through cross reactivity with environmental allergens. Avoidance of the offending allergenic drug may impact disease management, quality of life, and life expectancy. Precision medicine provides new tools for the understanding and management of hypersensitivity reactions (HSRs), as well as a personalized treatment approach for IgE (Immunoglobuline E) and non-IgE mediated HSRs with drug desensitization (DS)...
June 20, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28605372/a-component-resolved-diagnostic-approach-for-a-study-on-grass-pollen-allergens-in-chinese-southerners-with-allergic-rhinitis-and-or-asthma
#3
Wenting Luo, Guichang Pan, Huimin Huang, Peiyan Zheng, Nili Wei, Yifei Zhang, Guangqiao Zeng, Baoqing Sun
Sensitization to grass pollen imposes a global risk for allergic airway diseases. Although prevention relies on local investigation of the pollen allergens, data on this topic are limited in southern China. Any available data were obtained by self-report questionnaires, skin prick tests, and total or specific IgE tests using crude extracts. For many reasons, these methods are unreliable. Serum sIgE reactivity to Bermuda grass, Timothy grass, and Humulus scandens allergens in a cohort of patients from Greater Guangzhou (southern China's largest city and its outskirts) with allergic rhinitis and/or asthma were examined using a fully-automated immunoassay analyzer as a component-resolved diagnostics (CRD) tool...
June 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28550987/molecular-diagnostics-and-lack-of-clinical-allergy-in-helminth-endemic-areas-in-indonesia
#4
Firdaus Hamid, Serge A Versteeg, Aprilianto E Wiria, Linda J Wammes, Sitti Wahyuni, Taniawati Supali, Erliyani Sartono, Ronald van Ree, Maria Yazdanbakhsh
Allergen microarray characterization of sensitization to common allergen sources in a helminth-endemic area of Indonesia shows that helminth induced cross-reactivity to cross-reactive carbohydrate determinants (CCD), and not primary sensitization to their major allergens, is the dominant feature.
May 24, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28543717/poaceae-pollen-as-the-leading-aeroallergen-worldwide-a-review
#5
REVIEW
H García-Mozo
The Poaceae family comprises over 12,000 wind-pollinated species which release large amounts of pollen into the atmosphere. Poaceae pollen is currently regarded as the leading airborne biological pollutant and the chief cause of pollen-allergy worldwide. Sensitization rates vary by country, and those variations are reviewed here. Grass pollen allergens are grouped according to their protein structure and function. In Poaceae, although species belonging to different sub-families are characterized by distinct allergen subsets, there is a considerable degree of cross-reactivity between many species...
May 22, 2017: Allergy
https://www.readbyqxmd.com/read/28535932/charting-novel-allergens-from-date-palm-pollen-phoenix-sylvestris-using-homology-driven-proteomics
#6
Bodhisattwa Saha, Naren Pandey, Swati Gupta Bhattacharya
Pollen grains from Phoenix sylvestris (date palm), a commonly cultivated tree in India has been found to cause severe allergic diseases in an increasing percentage of hypersensitive individuals. To unearth its allergenic components, pollen protein were profiled by two-dimensional gel electrophoresis followed by immunoblotting with date palm pollen sensitive patient sera. Allergens were identified by MALDI-TOF/TOF employing a layered proteomic approach combining conventional database dependent search and manual de novo sequencing followed by homology-based search as Phoenix sylvestris is unsequenced...
May 20, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28532654/flexible-ige-epitope-containing-domains-of-phl-p-5-cause-high-allergenic-activity
#7
Christoph Göbl, Margarete Focke-Tejkl, Nazanin Najafi, Evelyne Schrank, Tobias Madl, Simone Kosol, Christoph Madritsch, Yulia Dorofeeva, Sabine Flicker, Josef Thalhamer, Rudolf Valenta, Klaus Zangger, Nico Tjandra
No abstract text is available yet for this article.
May 19, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28511284/non-mix-fragrances-are-top-sensitizers-in-consecutive-dermatitis-patients%C3%A2-%C3%A2-a-cross-sectional-study-of-the-26-eu-labelled-fragrance-allergens
#8
Niels H Bennike, Claus Zachariae, Jeanne D Johansen
BACKGROUND: For cosmetics, it is mandatory to label 26 fragrance substances, including all constituents of fragrance mix I (FM I) and fragrance mix II (FM II). Earlier reports have not included oxidized R-limonene [hydroperoxides of R-limonene (Lim-OOH)] and oxidized linalool [hydroperoxides of linalool (Lin-OOH)], and breakdown testing of FM I and FM II has mainly been performed in selected, mix-positive patients. OBJECTIVES: To report the prevalence of sensitization to the 26 fragrances, and to assess concomitant reactivity to FM I and/or FM II...
May 16, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28506851/immunocap-cellulose-displays-cross-reactive-carbohydrate-ccd-epitopes-and-can-cause-false-positive-test-results-in-patients-with-high-anti-ccd-ige-antibody-levels
#9
Wolfgang Hemmer, Friedrich Altmann, Friedrich Holzweber, Clemens Gruber, Felix Wantke, Stefan Wöhrl
RATIONALE: Cross-reactive carbohydrate determinants (CCDs) in plants and insect venoms are a common cause of irrelevant positive test results during in-vitro allergy diagnosis. We observed that some CCD-positive sera show non-specific IgE-binding even with CCD-free recombinant allergens when using the Phadia ImmunoCAP platform. OBJECTIVE: We investigated if cellulose used as allergen carrier in the ImmunoCAP harbors residual N-glycans causing non-specific background-binding in CCD-positive sera...
May 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28503403/diagnostics-in-hymenoptera-venom-allergy-current-concepts-and-developments-with-special-focus-on-molecular-allergy-diagnostics
#10
Thilo Jakob, David Rafei-Shamsabadi, Edzard Spillner, Sabine Müller
BACKGROUND: The high rate of asymptomatic sensitization to Hymenoptera venom, difficulty in correctly identifying Hymenoptera and loss of sensitization over time make an accurate diagnosis of Hymenoptera venom allergy challenging. Although routine diagnostic tests encompassing skin tests and the detection of venom-specific IgE antibodies with whole venom preparations are reliable, they offer insufficient precision in the case of double sensitized patients or in those with a history of sting anaphylaxis, in whom sensitization cannot be proven or only to the presumably wrong venom...
2017: Allergo Journal International
https://www.readbyqxmd.com/read/28502519/-blomia-tropicalis-a-house-dust-mite-in-the-tropics
#11
REVIEW
L Guilleminault, C Viala-Gastan
INTRODUCTION: Blomia tropicalis is a mite that belongs to the superfamily of Glycyphagidae. Initially described as a storage mite, it is now considered as a house dust mite of tropical and sub-tropical areas. STATE OF THE ART: Sensitization to this mite is very common in South America and Southeast Asia. Epidemiological studies have also found sensitization to this mite in Africa and Central America. Blo t 5 is the major allergen of B. tropicalis. Co-sensitization to other house dust mites such as Dermatophagoides pteronyssinus (Der p) and Dermatophagoides farinae (Der f) is very common...
May 12, 2017: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/28501976/component-resolved-diagnosis-in-hymenoptera-anaphylaxis
#12
REVIEW
D Tomsitz, K Brockow
PURPOSE OF REVIEW: Hymenoptera anaphylaxis is one of the leading causes of severe allergic reactions and can be fatal. Venom-specific immunotherapy (VIT) can prevent a life-threatening reaction; however, confirmation of an allergy to a Hymenoptera venom is a prerequisite before starting such a treatment. Component resolved diagnostics (CRD) have helped to better identify the responsible allergen. RECENT FINDINGS: Many new insect venom allergens have been identified within the last few years...
June 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28500661/is-mealworm-or-shrimp-allergy-indicative-for-food-allergy-to-insects
#13
Henrike Chp Broekman, André C Knulst, Govardus de Jong, Marco Gaspari, Constance F den Hartog Jager, Geert F Houben, Kitty Cm Verhoeckx
SCOPE: The growing world population is a key driver for the exploration of sustainable protein sources to ensure food security. Mealworm and other insects are promising candidates. Previously we found that shrimp allergic patients are at risk for mealworm allergy, and that mealworm can induce a primary allergy 3.This study set out to investigate the allergenic potential of edible insects, suggested for human consumption by agencies such as WHO/FAO, in both the shrimp (potentially cross-reactive) and primary mealworm allergic population...
May 12, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28485877/diagnostic-precision-of-component-resolved-vs-extract-based-in-vitro-diagnosis-of-hymenoptera-venom-allergy-effects-on-clinical-management
#14
Florian Seyfarth, Diana Miguel, Sibylle Schliemann, Uta-Christina Hipler
BACKGROUND: The measurement of specific IgE (sIgE) antibodies plays a key role in the diagnosis of honeybee and wasp venom allergy. In recent years, component-resolved diagnosis (CRD) has been introduced, which allows for the measurement of sIgE antibodies against Api m 1, Ves v 1, Ves v 5, and Pol d 5, as well as cross-reactive carbohydrate determinants (CCDs). These tests are intended to help determine the clinical relevance of any given sensitization, especially in patients with dual sensitization...
May 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28479330/glycans-and-glycan-specific-ige-in-clinical-and-molecular-allergology-sensitization-diagnostics-and-clinical-symptoms
#15
Arne Homann, Gabriele Schramm, Uta Jappe
Glycan-specific IgE antibodies cross-react with highly similar or even identical carbohydrate structures on a variety of different natural allergens, the so-called cross-reactive carbohydrate determinants (CCDs). In clinical practice CCDs often interfere with the specificity of in vitro allergy diagnostics, thus impairing allergy therapy decisions for individual patients. Strikingly, these IgE antibodies directed against CCDs often do not cause clinically relevant allergy symptoms. On the other hand, the IgE-binding glycan allergen galactose-α-(1,3)-galactose (α-Gal) is associated with IgE-mediated delayed anaphylaxis in meat allergy...
May 4, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28478921/mucosal-and-systemic-immune-response-to-sublingual-or-intranasal-immunization-with-phosphorylcholine
#16
Yoshiko Maseda, Junichiro Ohori, Norimitsu Tanaka, Hiromi Nagano, Keiichi Miyashita, Yuichi Kurono
OBJECTIVE: Phosphorylcholine (PC) is a structural component of a wide variety of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. Here, the immune response in mice to PC immunization via the sublingual (SL) route versus the intranasal (IN) route was investigated in terms of efficacy and safety. METHODS: BALB/c mice were immunized with PC-keyhole limpet hemocyanin (KLH) plus cholera toxin (CT) or CT alone via the IN or SL route. The immune response generated was studied in terms of PC-specific antibody titers, interferon (IFN)-γ and interleukin (IL)-4 production by CD4(+) T cells, and cross-reactivity of PC-specific immunoglobulin (Ig)-A antibodies in nasal washes against S...
May 4, 2017: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/28467993/recombinant-allergens-in-structural-biology-diagnosis-and-immunotherapy
#17
Angelika Tscheppe, Heimo Breiteneder
The years 1988-1995 witnessed the beginning of allergen cloning and the generation of recombinant allergens, which opened up new avenues for the diagnosis and research of human allergic diseases. Most crystal and solution structures of allergens have been obtained using recombinant allergens. Structural information on allergens allows insights into their evolutionary biology, illustrates clinically observed cross-reactivities, and makes the design of hypoallergenic derivatives for allergy vaccines possible...
2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28464293/amb-a-1-isoforms-unequal-siblings-with-distinct-immunological-features
#18
Martin Wolf, Teresa E Twaroch, Sara Huber, Manuel Reithofer, Markus Steiner, Lorenz Aglas, Michael Hauser, Iris Aloisi, Claudia Asam, Heidi Hofer, Maria A Parigiani, Christof Ebner, Barbara Bohle, Peter Briza, Neubauer Angela, Frank Stolz, Beatrice Jahn-Schmid, Michael Wallner, Fatima Ferreira
BACKGROUND: Ragweed pollen represents a major allergy risk factor. Ragweed extracts contain five different isoforms of the major allergen Amb a 1. However, the immunologic characteristics of Amb a 1 isoforms are not fully investigated. Here we compared the physicochemical and immunological properties of three most important Amb a 1 isoforms. METHODS: After purification, the isoforms were physicochemically characterized, tested for antibody-binding and induction of human T cell proliferative responses...
May 2, 2017: Allergy
https://www.readbyqxmd.com/read/28439939/identification-of-a-polygalacturonase-cup-s-2-as-the-major-ccd-bearing-allergen-in-cupressus-sempervirens-pollen
#19
Y Shahali, J-P Sutra, C Hilger, K Swiontek, I Haddad, J Vinh, L Guilloux, D Charpin, H Sénéchal, P Poncet
As IgE glyco-epitopes, also referred to as cross-reactive carbohydrate determinants (CCDs), can share significant structural homologies between different plants, they are prone to extensive cross-reactivity among allergen pollen extracts. Here, cypress pollen allergens, especially a polygalacturonase (PG), were further characterized using double one-dimensional electrophoresis (D1-DE). The presence of specific IgE directed against CCDs was investigated by bromelain IgE inhibition and concanavalin A binding assays using sera of cypress pollen-sensitized patients...
April 25, 2017: Allergy
https://www.readbyqxmd.com/read/28439905/der-f-35-an-md-2-like-house-dust-mite-allergen-that-cross-reacts-with-der-f-2-and-pso-o-2
#20
T Fujimura, T Aki, T Isobe, A Matsuoka, T Hayashi, K Ono, S Kawamoto
BACKGROUND: Dermatophagoides farinae is a source of airborne house dust mite (HDM) allergens. We elucidated IgE-reactive allergens from D. farinae by two-dimensional immunoblotting-based allergenome analysis, and identified one new allergen, named Der f 35, that possesses IgE-binding capacity comparable to that of Der f 2. The aim of this study was to clarify the allergenic capacity of new HDM allergen Der f 35. METHODS: We cloned der f 35 from D. farinae mRNA and produced recombinant Der f 35 in Escherichia coli...
April 25, 2017: Allergy
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