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allergen cross-reactive

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https://www.readbyqxmd.com/read/29046027/-frequency-of-skin-reactivity-to-food-allergens-in-allergic-patients
#1
Heriberto Camero-Martínez, Aída Inés López-García, Daniela Rivero-Yeverino, Chrystopherson Gengyny Caballero-López, Oswaldo Arana-Muñoz, Sergio Papaqui-Tapia, Isabel Cristina Rojas-Méndez, Elizabeth Vázquez-Rojas
BACKGROUND: Food allergy is deemed to have a worldwide prevalence ranging from 2 to 10 %. OBJECTIVE: To determine the frequency of skin reactivity to food allergens by age groups. METHODS: Cross-sectional, descriptive, prolective, observational study. Patients aged from 2 to 64 years with symptoms consistent with allergic disease were included. Skin prick tests were carried out with food allergens. Frequencies and percentages were estimated...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29038898/molecular-and-immunological-characterisation-of-tropomyosin-from-anisakis-pegreffii
#2
Abdouslam Asnoussi, Ibukun E Aibinu, Robin B Gasser, Andreas L Lopata, Peter M Smooker
Tropomyosin (TM) is a major allergen in shellfish, known to cross-react with mite, cockroach and/or some roundworm (nematode) TM. In this study, we aimed to express and purify TM from the parasitic nematode Anisakis pegreffii and also to characterise its cross-reactivity with TM from shellfish. A. pegreffii was isolated from the flathead tiger fish (Neoplatycephalus richardsoni) and characterised using single-strand conformation polymorphism (SSCP)-based sequencing of the first and second internal transcribed spacers (ITS-1 and ITS-2) of nuclear ribosomal DNA...
October 16, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28992615/contributions-and-future-directions-for-structural-biology-in-the-study-of-allergens
#3
Geoffrey A Mueller
Allergy is defined as an inappropriate immune response to something normally considered harmless. The symptomatic immune response is driven by IgE antibodies directed against allergens. The study of allergens has contributed significantly to our understanding of allergic disease in 3 main areas. First, identifying allergens as the cause of symptoms and developing allergen standards has led to many advances in exposure assessment and patient diagnostics. Second, a biochemical understanding of allergens has suggested a number of hypotheses related to the mechanisms of allergic sensitization...
October 10, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28960341/distinct-epitope-structures-of-defensin-like-proteins-linked-to-proline-rich-regions-give-rise-to-differences-in-their-allergenic-activity
#4
I Pablos, S Eichhorn, Y Machado, P Briza, A Neunkirchner, B Jahn-Schmid, S Wildner, W T Soh, C Ebner, J-W Park, W F Pickl, N Arora, S Vieths, F Ferreira, G Gadermaier
BACKGROUND: Art v 1, Amb a 4, and Par h 1 are allergenic defensin-polyproline-linked proteins present in mugwort, ragweed, and feverfew pollen, respectively. We aimed to investigate the physicochemical and immunological features underlying the different allergenic capacities of those allergens. METHODS: Recombinant defensin-polyproline-linked proteins were expressed in E. coli and physicochemically characterized in detail regarding identity, secondary structure, and aggregation status...
September 27, 2017: Allergy
https://www.readbyqxmd.com/read/28960180/salsola-kali-cross-reacts-extensively-with-salsola-imbricata
#5
M Al-Ahmad, T Rodriguez-Bouza, N Fakim, F Pineda
BACKGROUND: There are no studies on the cross-reactivity between Salsola kali and Salsola imbricata pollens. The main goal is to compare the degree of the cross-reactivity between Salsola kali and Salsola imbricata, and secondly to compare the various common allergen components between Salsola kali and Salsola imbricata. METHODS: Serum from rhinitis patients with or without asthma living in Kuwait presenting with a positive skin test to Salsola kali were obtained...
September 29, 2017: Journal of Investigational Allergology & Clinical Immunology
https://www.readbyqxmd.com/read/28950267/detection-of-the-peanut-allergens-ara-h-2-and-ara-h-6-in-human-breast-milk-development-of-2-sensitive-and-specific-sandwich-elisa-assays
#6
Frauke Schocker, Alexandra Scharf, Skadi Kull, Uta Jappe
BACKGROUND: Little is known about breast milk as a vehicle for tolerance development or sensitization to peanuts very early in life. Thus, well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. METHODS: For the quantification of the marker allergens Ara h 2 and Ara h 6 in the low nanogram per milliliter range in breast milk samples of a German cohort, sensitive and highly specific sandwich ELISAs were optimized and validated...
September 27, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28944625/allergy-to-peanut-soybean-and-other-legumes-recent-advances-in-allergen-characterization-stability-to-processing-and-ige-cross-reactivity
#7
REVIEW
Beatriz Cabanillas, Uta Jappe, Natalija Novak
Peanut and soybean are members of the Leguminosae family. They are two of the eight foods that account for the most significant food allergies in the US and Europe. Allergic reactions to other legume species can be of importance in other regions of the world. The major allergens from peanut and soybean have been extensively analyzed and members of new protein families identified as potential marker allergens for symptom severity. Important recent advances concerning their molecular properties or clinical relevance have been made...
September 25, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28925060/current-food-allergenic-risk-assessment-is-it-fit-for-novel-foods-status-quo-and-identification-of-gaps
#8
REVIEW
Gabriel Mazzucchelli, Thomas Holzhauser, Tanja Cirkovic-Velickovic, Araceli Diaz-Perales, Elena Molina, Paola Roncada, Pedro Rodrigues, Kitty Verhoeckx, Karin Hoffmann-Sommergruber
Food allergies are recognised as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well known foods and foods containing genetically modified ingredients was installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources...
September 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28923489/severe-anaphylaxis-due-to-crocodile-meat-allergy-exhibiting-wide-cross-reactivity-with-fish-allergens
#9
Elisa Haroun-Díaz, Natalia Blanca-López, María Vázquez de la Torre, Francisco Javier Ruano, Maria Luisa Somoza Álvarez, Moísés Labrador Horrillo, Borja Bartolomé, Miguel Blanca, Gabriela Canto Díez
No abstract text is available yet for this article.
September 8, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28919435/ultrasensitive-and-rapid-immuno-detection-of-human-ige-anti-therapeutic-horse-sera-using-an-electrochemical-immunosensor
#10
Isis C Prado, André L A Souza, David W Provance-Jr, Ricardo J Cassella, Salvatore G De-Simone
Antivenom allergy disease mediated by patient IgE is an important public health care concern. To improve detection of hypersensitive individuals prior to passive antibody therapy, an amperometric immunosensor was developed to detect reactive human IgE. Whole horse IgG3 (hoIgG3) was immobilized onto the surface of carbon or gold screen-printed electrodes through a cross-linking solution of glutaraldehyde on a chitosan film. Sera from persons with a known allergic response to hoIgG3 or non-allergic individuals was applied to the sensor...
September 14, 2017: Analytical Biochemistry
https://www.readbyqxmd.com/read/28904280/food-dependent-exercise-induced-anaphylaxis-due-to-ingestion-of-mikan-citrus-unshiu
#11
Yutaka Tanaka, Marie Sugihara, Shuntaro Tsumagari, Nobue Takamatsu, Kazuyuki Kurihara
A 12-year-old girl was referred to our hospital owing to repeated anaphylactic reactions induced by exercise after meals. Food-dependent exercise-induced anaphylaxis (FDEIAn) was suspected. However, sequential tests of typical foods, including egg, milk, soy, and wheat, in combination with exercise, were all negative.The results of the skin prick test (SPT) for Citrus unshiu and specific IgE test for orange and grapefruit were positive. Although no symptoms were noted after an exercise challenge combined with the ingestion of only Citrus unshiu, an anaphylactic reaction was induced by additional acetyl-salicylic acid...
2017: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/28873746/white-fruited-strawberry-genotypes-are-not-per-se-hypoallergenic
#12
Katrin Franz-Oberdorf, Bernadette Eberlein, Kathrin Edelmann, Philip Bleicher, Elisabeth Kurze, Dominic Helm, Klaus Olbricht, Ulf Darsow, Johannes Ring, Wilfried Schwab
The strawberry fruit Fra a 1-proteins are homologues of the major birch pollen allergen Bet v 1 and have essential biological functions in pigment formation during fruit ripening. Patients affected by allergy against birch pollen tolerated fruits of a naturally occurring white-fruited F.×ananassa genotype, which showed reduced levels of Fra a 1 proteins along with enzymes of the anthocyanin pigment pathway. We evaluated the cross-reactive allergenic potential of a number of naturally occurring white- and red-fruited strawberry varieties to detect genotypes with low allergenic reactivity, whose fruit might be tolerated by patients with mild allergy...
October 2017: Food Research International
https://www.readbyqxmd.com/read/28870463/efficacy-and-safety-of-4-months-of-sublingual-immunotherapy-with-recombinant-mal-d-1-and-bet-v-1-in-patients-with-birch-pollen-related-apple-allergy
#13
Tamar Kinaciyan, Birgit Nagl, Sandra Faustmann, Florian Frommlet, Stephan Kopp, Martin Wolkersdorfer, Stefan Wöhrl, Katharina Bastl, Hans Huber, Uwe Berger, Barbara Bohle
BACKGROUND: Birch pollen-related apple allergy is among the most prevalent food allergies in adolescent/adult individuals and mainly results from sensitization to the major birch pollen allergen Bet v 1 and subsequent cross-reaction with the apple protein Mal d 1. However, specific immunotherapy with birch pollen has inconsistent effects on apple allergy. OBJECTIVE: To compare the safety and efficacy of sublingual immunotherapy (SLIT) with two formulations containing either recombinant (r) Mal d 1 or Bet v 1 on birch pollen-related apple allergy...
September 1, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28866404/fresh-water-marine-and-terrestrial-cyanobacteria-display-distinct-allergen-characteristics
#14
Naama Lang-Yona, Anna Theresa Kunert, Lothar Vogel, Christopher Johannes Kampf, Iris Bellinghausen, Joachim Saloga, Anne Schink, Kira Ziegler, Kurt Lucas, Detlef Schuppan, Ulrich Pöschl, Bettina Weber, Janine Fröhlich-Nowoisky
During the last decades, global cyanobacteria biomass increased due to climate change as well as industrial usage for production of biofuels and food supplements. Thus, there is a need for thorough characterization of their potential health risks, including allergenicity. We therefore aimed to identify and characterize similarities in allergenic potential of cyanobacteria originating from the major ecological environments. Different cyanobacterial taxa were tested for immunoreactivity with IgE from allergic donors and non-allergic controls using immunoblot and ELISA...
August 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28855606/a-cross-sectional-observational-study-on-allergen-specific-ige-positivity-in-a-southeast-coastal-versus-a-southwest-inland-region-of-china
#15
Guangqiao Zeng, Wenting Luo, Zehong Wu, Ling Li, Peiyan Zheng, Huimin Huang, Nili Wei, Jiaying Luo, Baoqing Sun, Yong Liu
Few studies addressed trans-regional differences in allergen sensitization between areas within a similar latitudinal range but with distinct geomorphological features. We investigated specific IgE (sIgE) positivity to common allergens in populations from two southern China provinces. Using a uniformed protocol, serum samples were collected from 2778 subjects with suspected atopy in coastal Guangdong and inland Yunnan. The overall prevalence of sIgE positivity were 57.8% (95% CI: 56.0%, 59.6%) from Guangdong vs 60...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28833127/effects-of-the-maillard-reaction-on-the-immunoreactivity-of-amandin-in-food-matrices
#16
Guneet S Chhabra, Changqi Liu, Mengna Su, Mahesh Venkatachalam, Kenneth H Roux, Shridhar K Sathe
Amandin is the major storage protein and allergen in almond seeds. Foods, containing almonds, subjected to thermal processing typically experience Maillard browning reaction. The resulting destruction of amino groups, protein glycation, and/or denaturation may alter amandin immunoreactivity. Amandin immunoreactivity of variously processed almond containing foods was therefore the focus of the current investigation. Commercial and laboratory prepared foods, including those likely to have been subjected to Maillard browning, were objectively assessed by determining Hunter L(*) , a(*) , b(*) values...
October 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28831729/diagnosis-of-allergy-to-mammals-and-fish-cross-reactive-vs-specific-markers
#17
REVIEW
Christiane Hilger, Marianne van Hage, Annette Kuehn
PURPOSE OF REVIEW: Allergen extracts are still widely used in allergy diagnosis as they are regarded as sensitive screening tools despite the fact that they may lack some minor allergens. Another drawback of extracts is their low specificity, which is due to the presence of cross-reactive allergens. Progress in allergen identification has disclosed a number of allergenic molecules of homologous sequence and structure which are present in different animal species. This review summarizes recent advances in mammalian and fish allergen identification and focuses on their clinical relevance...
August 22, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28829832/allergen-homologs-in-the-euroglyphus-maynei-draft-genome
#18
S Dean Rider, Marjorie S Morgan, Larry G Arlian
Euroglyphus maynei is a house dust mite commonly found in homes worldwide and is the source of allergens that sensitize and induce allergic reactions in humans. It is the source of species-specific allergens as well as allergens that are cross-reactive with the allergens from house dust mites Dermatophagoides farinae and D. pteronyssinus, and the ectoparasitic scabies mite Sarcoptes scabiei. The genomics, proteomics and molecular biology of E. maynei and its allergens have not been as extensively investigated as those of D...
2017: PloS One
https://www.readbyqxmd.com/read/28818076/extensive-protein-hydrolyzation-is-indispensable-to-prevent-ige-mediated-poultry-allergen-recognition-in-dogs-and-cats
#19
Thierry Olivry, Jennifer Bexley, Isabelle Mougeot
BACKGROUND: The central premise for the commercialization of diets with hydrolyzed ingredients is that the small-sized digested peptides would be unable to crosslink allergen-specific IgE at the surface of tissue mast cells and induce their degranulation. Evidence for the validity of this concept to diagnose food allergies in dogs and cats is limited, however. Our objectives were to study the recognition of standard and variably hydrolyzed poultry extracts by sera from dogs and cats with elevated chicken-specific serum IgE...
August 17, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28804907/allergic-contact-dermatitis-caused-by-isobornyl-acrylate-in-freestyle%C3%A2-libre-a-newly-introduced-glucose-sensor
#20
Anne Herman, Olivier Aerts, Marie Baeck, Magnus Bruze, Christophe De Block, An Goossens, Nils Hamnerius, Sara Huygens, Dominique Maiter, Dominique Tennstedt, Bernard Vandeleene, Martin Mowitz
BACKGROUND: Glucose sensors, such as FreeStyle® Libre, are innovative medical devices developed for diabetes patients as a replacement for classic glucose meters, ensuring continuous glucose monitoring without the disadvantage of regular skin finger pricks. OBJECTIVES: To report several cases of allergic contact dermatitis caused by FreeStyle® Libre, and to report on isobornyl acrylate as a culprit allergen. PATIENTS AND METHODS: Fifteen patients presented with allergic contact dermatitis caused by FreeStyle® Libre...
August 14, 2017: Contact Dermatitis
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