keyword
MENU ▼
Read by QxMD icon Read
search

allergen cross-reactive

keyword
https://www.readbyqxmd.com/read/29666553/the-potential-of-component-resolved-diagnosis-in-laboratory-diagnostics-of-allergy
#1
REVIEW
Slavica Dodig, Ivana Čepelak
The initial laboratory approach in the diagnosis of allergies is to detect the type of allergic reaction, i.e. whether the patient's allergy is mediated by immunoglobulin E (IgE) or not. For this purpose, the concentration of total serum IgE (tIgE) and specific IgE (sIgE) are determined. Progress in laboratory diagnostics is the use of component-resolved diagnosis (CRD) which implies determination of sIgE against purified native and recombinant allergenic molecules. Component-resolved diagnosis is used in laboratory practice as singleplex and multiplex assays...
June 15, 2018: Biochemia Medica: časopis Hrvatskoga Društva Medicinskih Biokemičara
https://www.readbyqxmd.com/read/29627609/distinguishing-allergens-from-non-allergenic-homologues-using-physical-chemical-property-pcp-motifs
#2
Wenzhe Lu, Surendra S Negi, Catherine H Schein, Soheila J Maleki, Barry K Hurlburt, Werner Braun
Quantitative guidelines to distinguish allergenic proteins from related, but non-allergenic ones are urgently needed for regulatory agencies, biotech companies and physicians. In a previous study, we found that allergenic proteins populate a relatively small number of protein families, as characterized by the Pfam database. However, these families also contain non-allergenic proteins, meaning that allergenic determinants must lie within more discrete regions of the sequence. Thus, new methods are needed to discriminate allergenic proteins within those families...
April 5, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29622231/development-of-loop-mediated-isothermal-amplification-lamp-assays-for-the-rapid-detection-of-allergic-peanut-in-processed-food
#3
Shyang-Chwen Sheu, Po-Chuan Tsou, Yi-Yang Lien, Meng-Shiou Lee
Peanut is a widely and common used in many cuisines around the world. However, peanut is also one of the most important food allergen for causing anaphylactic reaction. To prevent allergic reaction, the best way is to avoid the food allergen or food containing allergic ingredient such as peanut before food consuming. Thus, to efficient and precisely detect the allergic ingredient, peanut or related product, is essential and required for maintain consumer's health or their interest. In this study, a loop-mediated isothermal amplification (LAMP) assay was developed for the detection of allergic peanut using specifically designed primer sets...
August 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29606424/lupine-allergen-detecting-capability-and-cross-reactivity-of-related-legumes-by-elisa
#4
Martina Koeberl, Michael F Sharp, Rongkai Tian, Saman Buddhadasa, Dean Clarke, James Roberts
Lupine belongs to the genus Lupinus and includes three species commonly consumed by humans. The Lupinus genus is closely related to other legumes, such as peanuts, soya, chickpeas, peas, lentils and beans. However, the consumption of lupine (and related legumes) can cause severe allergenic reactions. Therefore, reliable analytical detection methods are required for the analysis of food samples. In this study three commercially available ELISA test kits were analyzed for the detection capability of three common lupine species, as well as cross-reactivity to related legumes...
August 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29602574/ige-and-t-cell-responses-to-house-dust-mite-allergen-components
#5
Wayne R Thomas
Using the terminology for Dermatophagoides pteronyssinus, IgE responses to house dust mites have been shown to be mostly directed to the serodominant Der p 1, 2 and 23 allergen components with mid -tier responses to Der p 4, 5, 7 and 21 that are made by 30-50% of subjects with titers proportional to those of the serodominant specificities. This pattern can be seen to evolve in childhood and although responses to minor allergens appear to contribute little to the total IgE they are at least markers for a greater propensity to develop disease...
March 27, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29590653/misleading-allergens-in-the-diagnosis-of-latex-allergy-profilin-and-cross-reactive-carbohydrate-determinants
#6
Feridun Gürlek, Mehmet Ünsel, Ömür Ardeniz, Zeynep Peker Koc, Okan Gülbahar, Aytül Zerrin Sin, Ali Kokuludag, Nihal Mete Gokmen
BACKGROUND: It has been suggested that latex-specific IgE analysis may lead to false-positive results, especially in patients with pollen allergy. In the present study, the reasons underlying clinically irrelevant latex-specific IgE positivity were investigated. METHODS: Thirty patients with latex allergy (group 1), 89 patients sensitised to aeroallergens (group 2a), and 98 healthy individuals without allergy (group 2b) were enrolled. Participants from all 3 groups were subjected to skin prick tests with aeroallergens including latex, latex-specific IgE analysis (ImmunoCAP), and nasal provocation test with latex...
March 28, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29588070/parasite-allergens
#7
Luis Caraballo, Sandra Coronado
Human IgE against helminths is a normal component of the whole protective response elicitesd during infection, when specific IgE to a great number of antigens is produced; however, few of those IgE binding components are actually allergens. In general, considering the strong Th2/IgE responses during helminth infections is intriguing that they are not usually associated with allergic symptoms, which probably (but not exclusively) depends on parasite-induced immunomodulation. However, allergic manifestations have been described during some helminth infections such as ascariasis, strongyloidiasis, anisakiasis and hydatidosis...
March 24, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29549697/beta-expansin-of-bermuda-johnson-and-para-grass-pollens-is-a-major-cross-reactive-allergen-for-allergic-rhinitis-patients-in-subtropical-climate
#8
Punchama Pacharn, Wisuwat Songnual, Umaporn Siriwatanakul, Torpong Thongngarm, Onrapak Reamtong, Orathai Jirapongsananuruk, Chawewan Bunnag, Surapon Piboonpocanun
BACKGROUND: Subtropical grass pollens of Bermuda (BGP), Johnson (JGP), and Para or buffalo grass (PGP), are common causes of pollen allergies in warm climate area. Allergic rhinitis (AR) patients had positive skin prick test (SPT) to extract of these 3 grass pollens. However, no allergenic proteins of 3 grass pollens have never been studied. OBJECTIVE: To identify major allergens of BGP, JGP, and PGP in Thai grass pollen-allergic patients and to examine their sIgE cross-reactivity...
March 12, 2018: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/29525489/identification-of-cha-o-3-homolog-cry-j-4-from-cryptomeria-japonica-japanese-cedar-pollen-limitation-of-the-present-japanese-cedar-specific-asit
#9
Toshihiro Osada, Yuki Tanaka, Akira Yamada, Eiji Sasaki, Teruhiro Utsugi
BACKGROUND: About one-third of the Japanese population suffers from Japanese cedar pollinosis, which is frequently accompanied by Japanese cypress pollinosis. Recently, a novel major Japanese cypress pollen allergen, Cha o 3, was discovered. However, whether a Cha o 3 homolog is present in Japanese cedar pollen remains to be determined. METHODS: Western blot analysis was performed using Cha o 3-specific antiserum. In addition, cloning of the gene encoding Cry j 4 was conducted using total cDNA from the male flower of Japanese cedar trees...
March 7, 2018: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/29510117/antigenic-cross-reactivity-between-schistosoma-mansoni-and-pollen-allergens-from-the-birch-tree-betula-verrucosa-and-timothy-grass-phleum-pratense-involvement-of-shared-glycan-epitopes-and-implications-for-the-hygiene-hypothesis
#10
Joseph E Igetei, Marwa El-Faham, Susan Liddell, Gabriele Schramm, Michael J Doenhoff
Previous studies have shown that schistosome infection can protect against allergic symptoms, but the underlying mechanisms are still not fully understood. Here we have shown that rabbit IgG antibodies raised against Schistosoma mansoni soluble egg antigens (SmSEA) are cross-reactive with a wide array of molecules in Timothy grass pollen (TGP) and birch tree pollen (BTP). Five of the cross-reactive pollen molecules (two from TGP and three from BTP) were selected randomly and identified by tandem mass spectrometric (TMS) analysis to be, respectively, the TGP allergens Phl p 1 and Phl p 5b, and BTP glutathione S-transferase (GST), and the BTP allergens Bet v 1 and Bet v 6...
March 3, 2018: International Journal for Parasitology
https://www.readbyqxmd.com/read/29498135/a-preliminary-study-of-serum-ige-against-cross-reactive-carbohydrate-determinants-ccd-in-client-owned-atopic-dogs
#11
Britt J Levy, Douglas J DeBoer
BACKGROUND: Cross-reactive carbohydrate determinants (CCD) are defined carbohydrate portions of glycoprotein cell surface molecules common to many plant and insect species. Mammalian species recognize CCD as foreign antigens and can mount humoral immune responses against them. Approximately 20-37% of grass and venom allergic people possess circulating IgE against CCD; these antibodies are generally considered clinically irrelevant. Anti-CCD IgE is, however, recognized as a cause of false positive, clinically incongruent serum allergen test results in people; this phenomenon has not been investigated in animals...
March 1, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29391255/an-unexpected-protective-role-of-low-affinity-allergen-specific-igg-via-the-inhibitory-receptor-fc%C3%AE-riib
#12
Martin Bachmann, Monique Vogel, Lisha Zha, Fabiana Leoratti, Lichun He, Mona O Mohsen, Federico Storni, Mark Cragg
BACKGROUND: Induction of allergen-specific IgG antibodies is a critical parameter for successful specific immunotherapy (SIT). IgG antibodies may inhibit IgE-mediated mast cell activation by direct allergen-neutralization or via the inhibitory receptor FcγRIIb. The affinity of IgE antibodies to the allergen has been shown to be critical for cellular activation. OBJECTIVE: Here we addressed the question of the affinity thresholds of allergen-specific IgG antibodies for inhibition of mast cell activation by using 2 different monoclonal antibodies against the major cat allergen, Fel d 1, both in vitro and in vivo in mice...
January 29, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29377469/component-resolved-diagnostics-demonstrates-that-most-peanut-allergic-individuals-could-potentially-introduce-tree-nuts-to-their-diet
#13
R Uotila, A K Kukkonen, W M Blom, B Remington, J Westerhout, A S Pelkonen, M J Mäkelä
BACKGROUND: Nut allergy varies from pollen cross-allergy, to primary severe allergy with life-threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species-specific and cross-reactive allergens, is made possible via microarray analysis. OBJECTIVE: We sought to study the association of variable IgE sensitization profiles to clinical response in peanut-challenged children and adolescents in a birch-endemic region. In addition, we studied the avoidance of tree nuts and species-specific sensitizations...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29369414/molecular-sensitization-patterns-and-influence-of-molecular-diagnosis-in-immunotherapy-prescription-in-children-sensitized-to-both-grass-and-olive-pollen
#14
Ana Martínez-Cañavate Burgos, Javier Torres-Borrego, Ana Belén Molina Terán, Jose Luis Corzo, Blanca Esther Garcia, Ramón Rodríguez Pacheco, Carmen Moreno Aguilar, Ignacio Dávila
BACKGROUND: The overlapping grass and olive pollen seasons in Spain and the phenomenon of cross-reactivity can make it difficult to determine the true causative agent of seasonal allergic rhinitis when only skin prick tests with whole extracts are used. The aim of the GRAMOLE study was to determine sensitization patterns to the major grass and olive pollen allergens detected using specific recombinant IgE and to explore how this knowledge affected physicians' choice of allergen-specific immunotherapy...
January 25, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29358620/the-high-molecular-weight-dipeptidyl-peptidase-iv-pol-d-3-is-a-major-allergen-of-polistes-dominula-venom
#15
Maximilian Schiener, Christiane Hilger, Bernadette Eberlein, Mariona Pascal, Annette Kuehn, Dominique Revets, Sébastien Planchon, Gunilla Pietsch, Pilar Serrano, Carmen Moreno-Aguilar, Federico de la Roca, Tilo Biedermann, Ulf Darsow, Carsten B Schmidt-Weber, Markus Ollert, Simon Blank
Hymenoptera venom allergy can cause severe anaphylaxis in untreated patients. Polistes dominula is an important elicitor of venom allergy in Southern Europe as well as in the United States. Due to its increased spreading to more moderate climate zones, Polistes venom allergy is likely to gain importance also in these areas. So far, only few allergens of Polistes dominula venom were identified as basis for component-resolved diagnostics. Therefore, this study aimed to broaden the available panel of important Polistes venom allergens...
January 22, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29356186/the-blomia-tropicalis-allergen-blo-t-7-stimulates-innate-immune-signalling-pathways-through-tlr2
#16
T Soongrung, K Mongkorntanyatip, T Peepim, A Buaklin, M Le Mignon, N Malainual, E Nony, A Jacquet
BACKGROUND: Although the house dust mite species Blomia tropicalis is a leading cause of allergic diseases in tropical and subtropical regions, the identification and characterization of the allergenic proteins remain incomplete. OBJECTIVE: We aimed to characterize a recombinant form of Blo t 7 (rBlo t 7) in terms of IgE reactivity, lipid-binding activity and ability to stimulate innate immunity. METHODS: The mature Blo t 7 cDNA was cloned by PCR methods for the expression of a secreted form of the allergen in P...
April 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29331065/component-resolved-diagnostics-to-direct-in-venom-immunotherapy-important-steps-towards-precision-medicine
#17
REVIEW
S Blank, M B Bilò, M Ollert
Stings of Hymenoptera can induce IgE-mediated systemic and even fatal allergic reactions. Venom-specific immunotherapy (VIT) is the only disease-modifying and curative treatment of venom allergy. However, choosing the correct venom for VIT represents a necessary prerequisite for efficient protection against further anaphylactic sting reactions after VIT. In the past, therapeutic decisions based on the measurement of specific IgE (sIgE) levels to whole venom extracts were not always straightforward, especially when the patient was not able to identify the culprit insect...
April 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29327359/contact-sensitization-in-dental-technicians-with-occupational-contact-dermatitis-data-of-the-information-network-of-departments-of-dermatology-ivdk-2001-2015
#18
Annice Heratizadeh, Thomas Werfel, Steffen Schubert, Johannes Geier
BACKGROUND: Dental technicians (DTs) are at increased risk for allergic contact sensitization. OBJECTIVES: To assess the current spectrum of occupational sensitization in DTs with occupational contact dermatitis (OCD). METHODS: A retrospective analysis of Information Network of Departments of Dermatology patch test data from the years 2001-2015 concerning DTs with OCD was performed. RESULTS: Patients of the study group (226 DTs with OCD) were significantly more often diagnosed with allergic contact dermatitis (37...
April 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29319884/similar-localization-of-conformational-ige-epitopes-on-the-house-dust-mite-allergens-der-p-5-and-der-p-21-despite-limited-ige-cross-reactivity
#19
M Curin, T Garmatiuk, Y Resch-Marat, K W Chen, G Hofer, K Fauland, W Keller, W Hemmer, S Vrtala, M Focke-Tejkl, R Valenta
BACKGROUND: Due to high IgE recognition frequency and high allergenic activity, Der p 5 and Der p 21 are clinically important house dust mite (HDM) allergens. The objective of this study was to characterize the immunodominant IgE epitopes of Der p 5 and Der p 21 responsible for their high allergenic activity. METHODS: A panel of 12 overlapping peptides spanning the Der p 5 and Der p 21 sequence were synthesized to search for sequential IgE epitopes by direct testing for allergic patients' IgE reactivity...
January 10, 2018: Allergy
https://www.readbyqxmd.com/read/29315948/a-patient-specific-approach-to-develop-an-exclusion-diet-to-manage-food-allergy-in-infants-and-children
#20
REVIEW
C Venter, M Groetch, M Netting, R Meyer
Food allergy is becoming increasingly common in infants and young children. This article set out to explain the different factors that should be taken into account during an individualized allergy consultation: Foods to avoid and degree of avoidance, suitable alternatives, self-management skills, co- and cross-reactive allergens and novel allergens alongside the role of the industry in allergen avoidance, importance of nutritional aspects of the diet and the future directions that nutritional guidance make take...
February 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
keyword
keyword
111873
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"