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https://www.readbyqxmd.com/read/28108464/lower-extremity-peripheral-artery-disease-and-quality-of-life-among-older-individuals-in-the-community
#1
Aozhou Wu, Josef Coresh, Elizabeth Selvin, Hirofumi Tanaka, Gerardo Heiss, Alan T Hirsch, Bernard G Jaar, Kunihiro Matsushita
BACKGROUND: Evidence regarding the association of lower extremity peripheral arterial disease with quality of life (QOL) is mainly from selected clinical populations or relatively small clinical cohorts. Thus, we investigated this association in community-derived populations. METHODS AND RESULTS: Using data of 5115 participants aged 66 to 90 years from visit 5 (2011-2013) of the Atherosclerosis Risk in Communities Study, we quantified the associations of ankle-brachial index (ABI) with several QOL parameters, including 12-item Short-Form Health Survey (SF-12), after accounting for potential confounders using linear and logistic regression models...
January 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28097467/strenuous-exercise-and-cardiovascular-disease-outcomes
#2
REVIEW
Jonathan H Kim, Aaron L Baggish
PURPOSE OF REVIEW: This review summarizes several issues at the forefront of recent controversies involving the appropriate exercise dose including epidemiologic data describing mortality trends in those who engage in high levels of physical activity and recent observational data suggesting adverse cardiovascular outcomes among long-term endurance athletes. RECENT FINDINGS: The benefits of habitual and moderate levels of exercise on cardiovascular disease outcomes in the general population have been well established...
January 2017: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/28094226/relationship-between-age-and-cardiometabolic-index-in-japanese-men-and-women
#3
Ichiro Wakabayashi
BACKGROUND: Cardiometabolic index (CMI) is a new discriminator of the risk of diabetes and has been reported to be associated with the degree of atherosclerosis. However, it is unknown whether and how age influences CMI. METHODS: The subjects were Japanese men (n=35684) and women (n=18793) aged ≥35 and ≤70 years who had received periodic health examinations at workplaces. CMI and its association with diabetes were compared among different age groups in men and women...
January 13, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28078998/lipoprotein-a-management-pharmacological-and-apheretic-treatment
#4
Ruth Hanssen, Ioanna Gouni-Berthold
Lipoprotein (a) [Lp(a)] is an low-density lipoprotein (LDL)-like particle with an additional apolipoprotein, apolipoprotein (a), [apo(a)] attached to apolipoprotein B. Recent epidemiologic and Mendelian randomization studies have provided evidence that Lp(a) is causally related to the pathogenesis of atherosclerosis and cardiovascular disease (CVD). The risk association between Lp(a) concentrations and CVD is still controversial but seems to be continuous and without an obvious threshold Lp(a) level. Circulating concentrations of Lp(a) are genetically determined; desirable levels are amplt; 50 mg/dl...
12, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28067100/effects-of-a-single-bout-of-strenuous-exercise-on-platelet-activation-in-female-apoe-ldlr-mice
#5
K Przyborowski, H Kassassir, M Wojewoda, K Kmiecik, B Sitek, K Siewiera, A Zakrzewska, A M Rudolf, R Kostogrys, C Watala, J A Zoladz, S Chlopicki
Strenuous physical exercise leads to platelet activation that is normally counterbalanced by the production of endothelium-derived anti-platelet mediators, including prostacyclin (PGI2) and nitric oxide (NO). However, in the case of endothelial dysfunction, e.g. in atherosclerosis, there exists an increased risk for intravascular thrombosis during exercise that might be due to an impairment in endothelial anti-platelet mechanisms. In the present work, we evaluated platelet activation at rest and following a single bout of strenuous treadmill exercise in female ApoE/LDLR(-)(/-) mice with early (3-month-old) and advanced (7-month-old) atherosclerosis compared to female age-matched WT mice...
January 9, 2017: Platelets
https://www.readbyqxmd.com/read/28051354/effect-of-almond-supplementation-on-glycemia-and-cardiovascular-risk-factors-in-asian-indians-in-north-india-with-type-2-diabetes-mellitus-a-24-week-study
#6
Seema Gulati, Anoop Misra, Ravindra M Pandey
BACKGROUND: Type 2 diabetes (T2D) statistics have reached menacing proportions in India. Appropriate dietary intervention, as part of healthy lifestyle, is imperative to curb further spread of this disease. OBJECTIVES: This pre-post intervention study was conducted in New Delhi, India, to investigate the effects of daily consumption of almonds for 24 weeks in T2D subjects, specifically on measures of glycemia and cardiovascular disease (CVD) risk factors. METHODS AND STUDY DESIGN: In this study, the 24-week intervention period was preceded by a control diet and exercise run-in period of 3 weeks...
January 4, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28036119/impact-of-physical-activity-on-cardiovascular-status-in-obesity
#7
Lars Lin, Axel C Carlsson, Agneta Siegbahn, Johan Sundström, Johan Ärnlöv
BACKGROUND: We have recently shown that being physically active (PA) counteracts, but not eliminates the increased risk of future cardiovascular disease in over-weight and obese subjects. To investigate this further, we studied the impact of being normal weight, overweight and obese on multiple markers of subclinical cardiovascular disease in relation to physical activity. MATERIALS AND METHODS: At age 70, 1016 subjects were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study...
December 30, 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28028974/myocardial-ischaemia-coronary-atherosclerosis-and-pulmonary-pressure-elevation-in-antiphospholipid-syndrome-patients
#8
Agnieszka Padjas, Wojciech Płazak, Magdalena Celińska-Lowenhoff, Adam Mazurek, Carlo Perricone, Piotr Podolec, Jacek Musiał
BACKGROUND: Thrombotic events in antiphospholipid syndrome (APS) involve venous and arterial circulation with the possible involvement of coronary or pulmonary microcirculation. OBJECTIVES: To evaluate the influence of antiphospholipid antibodies (aPL) and on myocardial ischaemia assessed by single-photon emission computerized tomography (SPECT), coronary atherosclerosis assessed by multidetector computerized tomography (MDCT) and pulmonary pressure assessed by transthoracic echocardiography (TTE) in patients with primary antiphospholipid syndrome (PAPS)...
November 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28017965/exercise-adipokines-and-pediatric-obesity-a-meta-analysis-of-randomized-controlled-trials
#9
REVIEW
A García-Hermoso, R J M Ceballos-Ceballos, C E Poblete-Aro, A C Hackney, J Mota, R Ramírez-Vélez
Background/ObjectiveAdipokines are involved in the etiology of diabetes, insulin resistance, and the development of atherosclerosis and other latent-onset complications. The objective of this meta-analysis was to determine the effectiveness of exercise interventions on adipokines in pediatric obesity.Subjects/MethodA computerized search was made using three databases. The analysis was restricted to studies that examined the effect of exercise interventions on adipokines (adiponectin, leptin, resistin, and visfatin) in pediatric obesity (6-18 years old)...
December 26, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27997862/the-association-of-pulse-pressure-with-metabolic-syndrome-in-korean-elderly-a-nationwide-population-based-study
#10
Yu-Jin Kwon, Tae-Ha Chung, Jae-Yong Shim, Yong-Jae Lee
AIMS: Metabolic syndrome (MetS) is one of the most important issues in elderly people because of its association with ensuing cardiovascular disease (CVD). The components of MetS play a key role in the pathogenesis of arterial thickness and stiffness. Pulse pressure (PP), an easily accessible parameter in a basic health evaluation, has been documented as a marker of arterial stiffness and widespread atherosclerosis. The aim of our study was to assess the association between PP and MetS in Korean elderly people...
December 5, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27965912/impact-of-lifestyle-intervention-on-hdl-induced-enos-activation-and-cholesterol-efflux-capacity-in-obese-adolescent
#11
Jenny Wesnigk, Luc Bruyndonckx, Vicky Y Hoymans, Ann De Guchtenaere, Tina Fischer, Gerhard Schuler, Christiaan J Vrints, Volker Adams
Background. Endothelial dysfunction occurs in obese children and adolescent and is regarded as a key step in the development of atherosclerosis. Important components for the development of endothelial dysfunction are reduced activity of endothelial nitric oxide synthase (eNOS) and an increase in cholesterol deposition in the vessel wall, due to reduced reverse cholesterol transport (RCT) activity. High density lipoprotein (HDL) exhibits antiatherosclerotic properties including modulation of eNOS activity and cholesterol efflux capacity...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27935900/-thromboangiitis-obliterans-buerger-s-disease-state-of-the-art
#12
D D Zerbino, E A Zimba, N N Bagry
Thromboangiitis obliterans (Buerger's disease) is systemic vasculitis with predominant development of thrombotic occlusions of small-to-medium diameter arteries of distal portions of both upper and lower limbs. A distinctive feature of Buerger's disease from other vasculitides is the involvement of the venous bed into the pathological process in the form of migrating thrombophlebitis. The disease is encountered more often in young adult males, predominantly tobacco smokers. The clinical pattern is presented by symptoms of increasing insufficiency of blood supply of tissues of extremities...
2016: Angiologii︠a︡ i Sosudistai︠a︡ Khirurgii︠a︡, Angiology and Vascular Surgery
https://www.readbyqxmd.com/read/27917862/purslane-portulaca-oleracea-seed-consumption-and-aerobic-training-improves-biomarkers-associated-with-atherosclerosis-in-women-with-type-2-diabetes-t2d
#13
Firouzeh Dehghan, Rahman Soori, Khadijeh Gholami, Mitra Abolmaesoomi, Ashril Yusof, Sekaran Muniandy, Sara Heidarzadeh, Parvin Farzanegi, Mohammad Ali Azarbayjani
The aim of this study was to investigate the responses of atherosclerosis plaque biomarkers to purslane seed consumption and aerobic training in women with T2D. 196 women with T2D were assigned into; (1) placebo (PL), (2) aerobic training+placebo (AT + PL), 3) purslane seeds (PS), aerobic training+purslane seeds (AT + PS). The training program and purslane seeds consumption (2.5 g lunch and 5 g dinner) were carried out for 16 weeks. The components of purslane seed were identified and quantified by GC-MS...
December 5, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27863351/abnormal-heart-rate-response-during-cardiopulmonary-exercise-testing-identifies-cardiac-dysfunction-in-symptomatic-patients-with-non-obstructive-coronary-artery-disease
#14
Sundeep Chaudhry, Naresh Kumar, Hushyar Behbahani, Akshay Bagai, Binoy K Singh, Nick Menasco, Gregory D Lewis, Laurence Sperling, Jonathan Myers
BACKGROUND: Symptomatic non-obstructive coronary artery disease is a growing clinical dilemma for which contemporary testing is proving to be of limited clinical utility. New methods are needed to identify cardiac dysfunction. METHODS AND RESULTS: This is a prospective observational cohort study conducted from December 2013 to August 2015 in two outpatient cardiology clinics (symptomatic cohort) and 24 outpatient practices throughout the US (healthy cohort) with centralized methodology and monitoring to compare heart-rate responses during cardiopulmonary exercise testing (CPET)...
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27861342/long-term-effects-intensive-medical-therapy-on-the-development-and-progression-of-subclinical-atherosclerosis-and-the-metabolic-syndrome-in-chinese-patients-with-type-2-diabetes-mellitus
#15
Zhiwen Liu, Zhiguang Zhou, Gan Huang, Yang Xiao, Zhen Li, Cong Liu, Risu Na
BACKGROUND: Few studies have investigated the progression of subclinical atherosclerosis and metabolic syndrome (MetS) in Chinese patients with type 2 diabetes mellitus (T2DM). This study was to compare the long-term effects of intensive medical therapy on the development and progression of subclinical atherosclerosis and MetS in Chinese T2DM patients with that of a conventional treatment regimen. METHODS: A total of 316 T2DM patients were randomized to receive conventional pharmacological treatment or intensive medical therapy, consisting of diet and exercise counseling, from 2002 to 2014 at our hospital in Changsha, China...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27857958/substantive-hemodynamic-and-thermal-strain-upon-completing-lower-limb-hot-water-immersion-comparisons-with-treadmill-running
#16
Kate N Thomas, André M van Rij, Samuel J E Lucas, Andrew R Gray, James D Cotter
Exercise induces arterial flow patterns that promote functional and structural adaptations, improving functional capacity and reducing cardiovascular risk. While heat is produced by exercise, local and whole-body passive heating have recently been shown to generate favorable flow profiles and associated vascular adaptations in the upper limb. Flow responses to acute heating in the lower limbs have not yet been assessed, or directly compared to exercise, and other cardiovascular effects of lower-limb heating have not been fully characterized...
April 2016: Temperature: Multidisciplinary Biomedical Journal
https://www.readbyqxmd.com/read/27843053/prehypertension-is-associated-with-early-complications-of-atherosclerosis-but-not-with-exercise-capacity
#17
Mi-Hyang Jung, Sang-Hyun Ihm, Dong-Hyeon Lee, Woo-Baek Chung, Hae Ok Jung, Ho-Joong Youn
BACKGROUND: Prehypertension has a high risk of progression to hypertension, and intensive lifestyle modification including regular exercise is recommended for the management of prehypertensive individuals. However, data on the association between exercise capacity and hypertension status are limited. Therefore, we aimed 1) to define the characteristics of prehypertension, focusing on metabolic aspects and exercise capacity, and 2) to elucidate determinants of exercise capacity in healthy individuals without hypertension...
January 15, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27815563/association-of-serum-irisin-concentrations-with-presence-and-severity-of-coronary-artery-disease
#18
Wen Deng
BACKGROUND Irisin, an exercise-induced myokine, is closely correlated with obesity and body mass index. Obesity is one risk factor of coronary artery disease (CAD). Therefore, the present study aimed to determine if serum irisin concentrations are correlated with the presence and severity of CAD. MATERIAL AND METHODS Serum irisin concentrations were determined in 350 patients with CAD and in 214 healthy subjects. The severity of CAD was assessed by coronary atherosclerosis index (CAI). RESULTS Serum irisin concentrations were significantly lower in CAD patients compared with healthy controls...
November 5, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27801691/sudden-cardiac-death-in-transposition-of-the-great-arteries-with-a-mustard-or-senning-baffle-the-myocardial-ischemia-hypothesis
#19
Paul Khairy
PURPOSE OF REVIEW: The literature on sudden death in transposition of the great arteries (D-TGA) with atrial switch surgery is reviewed and a pathophysiological mechanism is proposed. RECENT FINDINGS: Over 80% of sudden deaths in patients with D-TGA and Mustard or Senning baffles occur during exercise. Factors most consistently associated with ventricular arrhythmias and sudden death include heart failure parameters and atrial arrhythmias. Atrial arrhythmias have been observed to trigger malignant ventricular arrhythmias...
January 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/27793103/the-sphinx-s-riddle-cardiovascular-involvement-in-autoimmune-rheumatic-disease
#20
REVIEW
Sophie Mavrogeni, George Markousis-Mavrogenis, Genovefa Kolovou
Factors leading to Cardiovascular Disease (CVD) in Autoimmune Rheumatic Diseases (ARD) include: a) atherosclerosis and macro-microvascular coronary artery disease b) pericardial, myocardial and vascular inflammation c) heart valve disease d) heart failure and e) pulmonary hypertension.Cardiology utilizes various non-invasive imaging modalities, such as rest/stress Electrocardiogram (ECG), echocardiography, nuclear imaging and more recently Cardiovascular Magnetic Resonance (CMR) to detect ischemic or inflammatory disease in ARD...
October 28, 2016: BMC Cardiovascular Disorders
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