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https://www.readbyqxmd.com/read/29433015/effect-of-strenuous-exercise-on-mediators-of-inflammation-in-patients-with-coronary-artery-disease
#1
Joanna Cwikiel, Ingebjørg Seljeflot, Eivind Berge, Ida Unhammer Njerve, Hilde Ulsaker, Harald Arnesen, Arnljot Flaa
BACKGROUND: Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed...
February 9, 2018: Cytokine
https://www.readbyqxmd.com/read/29416584/the-current-conditions-and-lifestyles-of-obese-university-students
#2
Natsumi Morito, Yasunori Suematsu, Rie Koyoshi, Yuhei Shiga, Takashi Kuwano, Atsushi Iwata, Kanta Fujimi, Akira Kawamura, Shin-Ichiro Miura
Background: The prevalence of cardiovascular diseases in Japan remains high, and the onset becomes early. Studies on the current conditions and lifestyles of obese university students may support early interventions to achieve lifestyle modification. Methods and Results: The results of periodic health examinations in 32,262 first-year university students revealed that 2,036 (6.3%) were obese. We performed a more detailed examination in 221 of these obese students (165 males and 56 females, age 19 ± 1 years) with study agreement from 2014 to 2016...
March 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29415907/guidance-for-pediatric-familial-hypercholesterolemia-2017
#3
Mariko Harada-Shiba, Takao Ohta, Akira Ohtake, Masatsune Ogura, Kazushige Dobashi, Atsushi Nohara, Shizuya Yamashita, Koutaro Yokote
This paper describes consensus statement by Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia (FH) in order to improve prognosis of FH.FH is a common genetic disease caused by mutations in genes related to low density lipoprotein (LDL) receptor pathway. Because patients with FH have high LDL cholesterol (LDL-C) levels from the birth, atherosclerosis begins and develops during childhood which determines the prognosis...
February 6, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29414191/a-glance-at-the-therapeutic-potential-of-irisin-against-diseases-involving-inflammation-oxidative-stress-and-apoptosis-an-introductory-review
#4
REVIEW
Hassan Askari, Sulail Fatima Rajani, Mansour Poorebrahim, Hamed Haghi-Aminjan, Ehsan Raeis-Abdollahi, Mohammad Abdollahi
Irisin is a hormone-like molecule mainly released by skeletal muscles in response to exercise. Irisin induces browning of the white adipose tissue and has been shown to regulate glucose and lipid homeostasis. Keeping its energy expenditure and metabolic properties in view, numerous studies have focused on its therapeutic potential for the treatment of metabolic disorders like obesity and type 2 diabetes. Recently, the anti-inflammatory, anti-apoptotic and anti-oxidative properties of irisin have received a great deal of attention of the scientific society...
January 29, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29386202/six-year-changes-in-physical-activity-and-the-risk-of-incident-heart-failure-the-atherosclerosis-risk-in-communities-aric-study
#5
Roberta Florido, Lucia Kwak, Mariana Lazo, Vijay Nambi, Haitham M Ahmed, Sheila M Hegde, Gary Gerstenblith, Roger S Blumenthal, Christie M Ballantyne, Elizabeth Selvin, Aaron R Folsom, Josef Coresh, Chiadi E Ndumele
Background -Higher physical activity (PA) is associated with lower heart failure (HF) risk. However, the impact of changes in PA on HF risk is unknown. Methods -We evaluated 11,351 ARIC participants (mean age 60 years) who attended Visit 3 (1993-95) and did not have a history of cardiovascular disease. Exercise PA was assessed using a modified Baecke questionnaire and categorized according to American Heart Association guidelines as recommended, intermediate, or poor. We used Cox regression models to characterize the association of 6-year changes in PA between the first (1987-1989) and third ARIC visits and HF risk...
January 31, 2018: Circulation
https://www.readbyqxmd.com/read/29379137/aerobic-exercise-for-a-duration-of-90%C3%A2-min-or-longer-per-week-may-reduce-the-atherogenic-index-of-plasma
#6
Shiwei Shen, Huajin Qi, Xingxian He, Yun Lu, Chengjian Yang, Feng Li, Ling Wang, Dongchang Qiang, Kedong Shui, Lin Zhou, Xiaofeng Weng, Zhenhai Shen, Liuxin Wu
The correlation between the weekly duration of aerobic exercise and atherogenic index of plasma (AIP) is still unknown. A cross-sectional study was conducted involving 27,827 middle-aged Chinese men who had health examinations in our hospital. The correlation between the duration of moderate-intensity aerobic exercise and AIP was determined. The mean AIP levels were 0.1166 ± 0.34475, 0.1167 ± 0.32637, and 0.0765 ± 0.32872 in the non-exercise (PA1), occasional exercise (PA2), and frequent exercise groups (PA3), respectively...
January 29, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29374670/care-cr-cardiovascular-and-cardiorespiratory-adaptations-to-routine-exercise-based-cardiac-rehabilitation-a-study-protocol-for-a-community-based-controlled-study-with-criterion-methods
#7
Simon Nichols, Fiona Nation, Toni Goodman, Andrew L Clark, Sean Carroll, Lee Ingle
INTRODUCTION: Cardiac rehabilitation (CR) reduces all-cause and cardiovascular mortality in patients with coronary heart disease (CHD). Much of this improvement has been attributed to the beneficial effects of structured exercise training. However, UK-based studies have not confirmed this. Improvements in survival and cardiovascular health are associated with concurrent improvements in cardiorespiratory fitness (CRF). It is therefore concerning that estimated CRF improvements resulting from UK-based CR are approximately one-third of those reported in international literature...
January 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29357096/associations-between-television-viewing-and-adiposity-among-south-asians
#8
Yichen Jin, Loretta DiPietro, Namratha R Kandula, Alka M Kanaya, Sameera A Talegawkar
OBJECTIVE: Sedentary behaviors related to television (TV) viewing are associated with adiposity; however, few investigations have focused on South Asians, an ethnicity particularly vulnerable to metabolic perturbations. This study examined the relationships between TV viewing and adiposity in a cohort of middle-aged and older South Asians. METHOD: Data were obtained from Mediators of Atherosclerosis in South Asians Living in America (MASALA) study (N = 906; mean age [standard deviation] = 55 [9...
January 22, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29306892/association-of-body-flexibility-and-carotid-atherosclerosis-in-japanese-middle-aged-men-a-cross-sectional-study
#9
Masataka Suwa, Takayuki Imoto, Akira Kida, Takashi Yokochi, Mitsunori Iwase, Kenji Kozawa
OBJECTIVE: This study examined the associations of body flexibility with carotid arterial remodelling, including intima-media thickness (IMT) and plaque formation in middle-aged men. METHODS: The subjects of this cross-sectional study included 1354 Japanese men aged 35-59 years without histories of stroke or cardiac diseases. The arm extensibility test, which can estimate flexibility of the upper extremity (composed of shoulder external rotation and forearm supination), and the sit-and-reach test were performed...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29275887/subclinical-hypothyroidism-is-associated-with-adverse-prognosis-in-heart-failure-patients
#10
Yu Sato, Akiomi Yoshihisa, Yusuke Kimishima, Takatoyo Kiko, Shunsuke Watanabe, Yuki Kanno, Satoshi Abe, Makiko Miyata, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Takafumi Ishida, Yasuchika Takeishi
BACKGROUND: It is widely recognized that overt hyper- as well as hypothyroidism are potential causes of heart failure (HF). Additionally it has been recently reported that subclinical hypothyroidism (sub-hypo) is associated with atherosclerosis, development of HF, and cardiovascular death. We aimed to clarify the effect of sub-hypo on prognosis of HF, and underlying hemodynamics and exercise capacity. METHODS: We measured the serum levels of thyroid stimulating hormone (TSH) and free thyroxine (FT4) in 1100 consecutive HF patients...
January 2018: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/29262409/early-markers-of-cardiovascular-risk-in-autosomal-dominant-polycystic-kidney-disease
#11
Silvia Lai, Daniela Mastroluca, Silvia Matino, Valeria Panebianco, Antonio Vitarelli, Lidia Capotosto, Irene Turinese, Paolo Marinelli, Marco Rossetti, Alessandro Galani, Pia Baiocchi, Anna R D'Angelo, Paolo Palange
BACKGROUND/AIMS: Cardiovascular disease is the most frequent cause of morbidity and mortality in autosomal dominant polycystic kidney disease (ADPKD) patients, often before the onset of renal failure, and the pathogenetic mechanism is not yet well elucidated. The aim of the study was to identify early and noninvasive markers of cardiovascular risk in young ADPKD patients, in the early stages of disease. METHODS: A total of 26 patients with ADPKD and 24 control group, matched for age and sex, were enrolled, and we have assessed inflammatory indexes, mineral metabolism, metabolic state and markers of atherosclerosis and endothelial dysfunction (carotid intima media thickness (IMT), ankle brachial index (ABI), flow mediated dilation (FMD), renal resistive index (RRI), left ventricular mass index (LVMI)) and cardiopulmonary exercise testing (CPET), maximal O2 uptake (V'O2max), and O2 uptake at lactic acid threshold (V'O2@LT)...
December 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29240651/acute-impact-of-different-exercise-modalities-on-arterial-and-platelet-function
#12
Andrew Haynes, Matthew D Linden, Elisa Robey, Gerald F Watts, P Hugh R Barrett, Louise H Naylor, Daniel J Green
PURPOSE: Acute coronary syndromes and ischemic stroke are associated with arterial events involving platelets, the endothelium and atherosclerosis. Whilst regular physical activity is associated with lower risk of cardiovascular events and mortality, risk is transiently increased during and immediately following participation in an acute bout of exercise. No previous study has investigated the acute impact of exercise on platelet activation and arterial function in the same participants; it is also unknown if responses are dependent on exercise modality...
December 13, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29238001/the-inverse-relationship-between-cardiorespiratory-fitness-and-intima-media-thickness-with-prehypertensive-middle-aged-women
#13
Dokyung Kim, Wonhah Park
Individuals with prehypertension have a greater risk of developing hypertension and cardiovascular disease than those with normal blood pressure. Good cardiorespiratory fitness has been associated with a reduced risk for cardiovascular diseases, but whether it is related to slower progression of early atherosclerosis is unclear. We evaluated 442 women, aged 40-60 years, with resting systolic blood pressure 120-139 mmHg and diastolic blood pressure 80-89 mmHg, defined as prehypertension in cross-sectional study...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29230906/longitudinal-observation-of-arterial-stiffness-in-junior-high-school-students
#14
Hiroshi Fujiwara, Hisakazu Nakajima, Fumio Inoue, Kitaro Kosaka, Hiroaki Asano, Kengo Yoshii
BACKGROUND: Early atherosclerotic change is found even in childhood, and there is an urgent need to clarify the factors causing childhood atherosclerosis and take preventive measures. Early detection of the contributing risk factors is crucial for preventive measures to be undertaken. Pulse wave velocity (PWV) is a widely used technique method for the assessment of atherosclerosis in children. METHODS: Lifestyle questionnaire, and baPWV values and anthropometric data were obtained from junior high school students in an urban area of Japan over a period of 3 years between 2006 and 2008...
December 12, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29192067/effect-of-myostatin-deletion-on-cardiac-and-microvascular-function
#15
Joshua T Butcher, M Irfan Ali, Merry W Ma, Cameron G McCarthy, Bianca N Islam, Lauren G Fox, James D Mintz, Sebastian Larion, David J Fulton, David W Stepp
The objective of this study is to test the hypothesis that increased muscle mass has positive effects on cardiovascular function. Specifically, we tested the hypothesis that increases in lean body mass caused by deletion of myostatin improves cardiac performance and vascular function. Echocardiography was used to quantify left ventricular function at baseline and after acute administration of propranolol and isoproterenol to assess β-adrenergic reactivity. Additionally, resistance vessels in several beds were removed, cannulated, pressurized to 60 mmHg and reactivity to vasoactive stimuli was assessed...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29190851/oxidized-low-density-lipoprotein-and-cell-adhesion-molecules-following-exercise-training
#16
Yunsuk Koh, Jin Park, Rick Carter
Elevated oxidized low-density lipoprotein (ox-LDL) and cell adhesion molecules are associated with inflammation and atherosclerosis. The role of exercise in circulating ox-LDL, enzyme mediators, and cell adhesion molecules are not clearly understood in obesity. As a randomized controlled design, 27 obese (BMI>30 kg/m2) sedentary men (N=13) and women (N=14) were randomly assigned to either an exercise (N=15) or a control (N=12) group. The exercise group performed a 60-min supervised treadmill exercise at moderate intensity (70% of HRmax) for 3 days per week for 4 weeks, while the control group did not exercise...
November 30, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29184434/manifestation-of-non-st-elevation-myocardial-infarction-due-to-hyperthyroidism-in-an-anomalous-right-coronary-artery
#17
Vicken Zeitjian, Carmel Moazez, Mehrdad Saririan, David L August, Ranjini Roy
Introduction: Anomalous origin of the right coronary artery (RCA) from the left coronary cusp of the aorta is a moderately rare but potentially life-threatening incident. Myocardial infarction (MI) and sudden cardiac death have been described with this anomaly, especially in those who engage in excessive exercise. However, this case study shows this incidence in association with hyperthyroidism. Case description: A previously healthy 51-year-old female with history of hypothyroidism presented with acute onset chest pain for 1 day...
2017: International Journal of General Medicine
https://www.readbyqxmd.com/read/29159794/high-fat-high-sugar-diet-induced-subendothelial-matrix-stiffening-is-mitigated-by-exercise
#18
Julie C Kohn, Julian Azar, Francesca Seta, Cynthia A Reinhart-King
Consumption of a high-fat, high-sugar diet and sedentary lifestyle are correlated with bulk arterial stiffening. While measurements of bulk arterial stiffening are used to assess cardiovascular health clinically, they cannot account for changes to the tissue occurring on the cellular scale. The compliance of the subendothelial matrix in the intima mediates vascular permeability, an initiating step in atherosclerosis. High-fat, high-sugar diet consumption and a sedentary lifestyle both cause micro-scale subendothelial matrix stiffening, but the impact of these factors in concert remains unknown...
November 20, 2017: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29145946/predicting-subclinical-atherosclerosis-in-low-risk%C3%A2-individuals-ideal-cardiovascular-health-score-and-fuster-bewat-score
#19
Juan Miguel Fernández-Alvira, Valentín Fuster, Stuart Pocock, Javier Sanz, Leticia Fernández-Friera, Martín Laclaustra, Rodrigo Fernández-Jiménez, José Mendiguren, Antonio Fernández-Ortiz, Borja Ibáñez, Héctor Bueno
BACKGROUND: The ideal cardiovascular health score (ICHS) is recommended for use in primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E], weight [W], alimentation [A], and tobacco [T]) score (FBS), are also available. OBJECTIVES: The purpose of this study was to compare the effectiveness of ICHS and FBS in predicting the presence and extent of subclinical atherosclerosis. METHODS: A total of 3,983 participants 40 to 54 years of age were enrolled in the PESA (Progression of Early Subclinical Atherosclerosis) cohort...
November 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29143147/-esc-guidelines-2017-on-peripheral-arterial-diseases-summary-of-the-most-important-recommendations-and-innovations
#20
C Espinola-Klein
The current European Society of Cardiology (ESC) guidelines on peripheral arterial diseases include recommendations on diagnostics and treatment of atherosclerotic manifestations in peripheral arteries. Because of the high coincidence of atherosclerosis in different arterial territories, screening for other atherosclerotic lesions is necessary in patients with clinical symptoms in one vascular bed. Consistent treatment of cardiovascular risk factors is important in all patients with peripheral atherosclerosis...
December 2017: Herz
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