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atherosclerosis exercise

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https://www.readbyqxmd.com/read/29867549/exercise-training-favorably-modulates-gene-and-protein-expression-that-regulate-arterial-cholesterol-content-in-cetp-transgenic-mice
#1
Paula R Pinto, Karolline S da Silva, Rodrigo T Iborra, Ligia S Okuda, Diego Gomes-Kjerulf, Guilherme S Ferreira, Adriana Machado-Lima, Debora D F M Rocco, Edna R Nakandakare, Ubiratan F Machado, Maria L Correa-Giannella, Sergio Catanozi, Marisa Passarelli
Aerobic exercise training (AET) improves the reverse cholesterol transport (RCT) in cholesteryl ester transfer protein-transgenic (CETP-tg) mice. We aimed at investigating the role of AET in the expression of genes and proteins involved in lipid flux in the aorta and macrophages of CETP-tg mice. Three-month-old male mice were randomly divided into trained (T; treadmill 15 m/min; 30 min/day) and sedentary (S) groups. After 6 weeks, peritoneal macrophages and the aortic arch were obtained immediately (0 h) or 48 h after the last exercise session...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29864776/sudden-cardiac-and-noncardiac-death-in-sports-epidemiology-causes-pathogenesis-and-prevention
#2
Giuseppe Lippi, Emmanuel J Favaloro, Fabian Sanchis-Gomar
Although few doubts remain that physical exercise should be widely promoted for maintenance of health and fitness, the risk of adverse events such as sudden death (especially due to cardiac causes, i.e., sudden cardiac death [SCD]) during exercise remains tangible. The overall risk of sudden death in athletes is relatively low (i.e., usually comprised between 0.1 and 38/100,000 person-years), and globally comparable to that of the general population. However, up to 20% of all sudden death cases are still recorded while exercising...
June 4, 2018: Seminars in Thrombosis and Hemostasis
https://www.readbyqxmd.com/read/29859711/relationship-of-serum-irisin-levels-to-prevalence-and-progression-of-coronary-artery-calcification-a-prospective-population-based-study
#3
Takashi Hisamatsu, Katsuyuki Miura, Hisatomi Arima, Akira Fujiyoshi, Aya Kadota, Sayaka Kadowaki, Maryam Zaid, Naoko Miyagawa, Atsushi Satoh, Ayako Kunimura, Minoru Horie, Hirotsugu Ueshima
BACKGROUND: The mechanisms by which exercise reduces the risk of coronary heart disease remain poorly understood. Irisin, an exercise-induced polypeptide secreted from skeletal muscles, is proposed to potentially mediate beneficial effects of exercise, especially in metabolic regulation and development of atherosclerosis. We examined whether higher serum irisin levels are associated with lower prevalence and progression of coronary atherosclerosis. METHODS AND RESULTS: We performed a prospective, population-based study of Japanese men aged 40-79 years without known coronary heart disease...
May 23, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29846604/long-term-testosterone-supplementation-in-older-men-attenuates-age-related-decline-in-aerobic-capacity
#4
Tinna Traustadóttir, S Mitchell Harman, Panayiotis Tsitouras, Karol M Pencina, Zhuoying Li, Thomas G Travison, Richard Eder, Renee Miciek, Jennifer McKinnon, Erin Woodbury, Shehzad Basaria, Shalender Bhasin, Thomas W Storer
Context: Testosterone increases skeletal muscle mass and strength, but long-term effects of testosterone supplementation on aerobic capacity (V˙O2peak) in healthy older men with low testosterone have not been evaluated. Objective: To determine the effects of testosterone supplementation on V˙O2peak during incremental cycle ergometry. Design: Testosterone's Effects on Atherosclerosis Progression in Aging Men trial: double-blind, randomized, placebo-controlled, parallel-group trial...
May 25, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29784903/exercise-ameliorates-endoplasmic-reticulum-stress-mediated-vascular-dysfunction-in-mesenteric-arteries-in-atherosclerosis
#5
Junyoung Hong, Kwangchan Kim, Eunkyung Park, Jonghae Lee, Melissa M Markofski, Sean P Marrelli, Yoonjung Park
Endoplasmic reticulum (ER) stress is closely associated with atherosclerosis, but the effects of exercise on ER stress-mediated endothelial dysfunction in atherosclerosis is not yet fully understood. We assessed endothelium-dependent vasodilation in isolated mesenteric arteries from wild type (WT), WT with exercise (WT-EX), ApoE knockout (ApoE KO), and ApoE KO mice with exercise (ApoE KO-EX). Vasodilation to acetylcholine (ACh) was elicited in the presence of inhibitors of ER stress, eNOS, caspase-1, and UCP-2 (Tudca, L-NAME, AC-YVARD-cmk, and Genipin, respectively) and the ER stress inducer (Tunicamycin)...
May 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29729688/comparison-of-serum-levels-of-il-6-il-8-tgf-%C3%AE-and-tnf-%C3%AE-in-coronary-artery-diseases-stable-angina-and-participants-with-normal-coronary-artery
#6
Zahra Sepehri Sepehri, Mohammad Masoomi, Fatemeh Ruzbehi, Zohreh Kiani, Ali Akbar Nasiri, Farhad Kohan, Mahmood Sheikh Fathollahi, Mohammad Kazemi Arababadi, Derek Kennedy, Gholamreza Asadikaram Asadikaram
Cytokines, which typically regulate the immune responses, play a role in cardiovascular diseases such as coronary artery diseases (CAD) and ischemic heart diseases (IHD). The aims of this study were to evaluate serum levels of IL-6, IL-8, TGF-β and TNF-α in patients with or without CAD, as well as stable angina, and to assess the effects of drug administration on the serum levels of these cytokines. Serum levels of the cytokines were analyzed in the three groups: patients with acute coronary syndrome, stable angina and participants with normal coronary arteries as controls...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29696063/the-response-of-intercellular-adhesion-molecule-1-to-exhaustive-submaximal-exercise-and-its-correlation-with-physiological-and-anthropometric-measures
#7
Hossein Taheri Chadorneshin, Ali Golestani, Fatemeh Jamali, Sakineh Mokhtari Motameni Shirvan, Hadi Sarir, Seyed Hosein Abtahi Eivary
Introduction: Intercellular adhesion molecule-1 (ICAM-1) acts as the main factor in the occurrence of atherosclerosis and inflammatory diseases. This study aimed to investigate the response of ICAM-1to exhaustive submaximal exercise and its correlation with maximal oxygen consumption (VO2max), body mass index (BMI), waist-hip ratio (WHR), body fat percentage (BF %) and calories burned during exercise (CB) in healthy men. Materials and methods: Thirteen healthy men (mean ± standard deviation: age 23 ± 3 years, weight 78 ± 4 kg, height 180 ± 4 cm) cooperated in this quasi-experimental study and performed a single bout of exhaustive submaximal exercise on a cycle ergometer...
January 2018: Journal of Medicine and Life
https://www.readbyqxmd.com/read/29688297/ten-year-association-of-coronary-artery-calcium-with-atherosclerotic-cardiovascular-disease-ascvd-events-the-multi-ethnic-study-of-atherosclerosis-mesa
#8
Matthew J Budoff, Rebekah Young, Gregory Burke, J Jeffrey Carr, Robert C Detrano, Aaron R Folsom, Richard Kronmal, Joao A C Lima, Kiang J Liu, Robyn L McClelland, Erin Michos, Wendy S Post, Steven Shea, Karol E Watson, Nathan D Wong
Aims: While coronary artery calcium (CAC) has been extensively validated for predicting clinical events, most outcome studies of CAC have evaluated coronary heart disease (CHD) rather than atherosclerotic cardiovascular disease (ASCVD) events (including stroke). Also, virtually all CAC studies are of short- or intermediate-term follow-up, so studies across multi-ethnic cohorts with long-term follow-up are warranted prior to widespread clinical use. We sought to evaluate the contribution of CAC using the population-based MESA cohort with over 10 years of follow-up for ASCVD events, and whether the association of CAC with events varied by sex, race/ethnicity, or age category...
April 23, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29648514/beneficial-impacts-of-regular-exercise-on-platelet-function-in-sedentary-older-adults-evidence-from-a-randomized-6-month-walking-trial
#9
Andrew Haynes, Matthew D Linden, Elisa Robey, Louise H Naylor, Philip N Ainslie, Kay L Cox, Nicola T Lautenschlager, Daniel J Green
Platelet activation, including the formation of monocyte platelet aggregates (MPAs), contributes to atherosclerosis, thrombus formation and acute coronary syndromes. Regular participation in exercise can lower cardiovascular risk, but little is known regarding the impact of exercise training on platelet function. We investigated the effect of 6 months of walking exercise on platelet function in sedentary older adults without significant cardiovascular disease. Twenty-seven participants were randomly allocated to 6 months of either: no-exercise (n=13) or 3 x 50 mins/wk of supervised centre-based walking (n=14)...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29584915/interleukin-1-blockade-in-cardiovascular-diseases-a-clinical-update
#10
Leo F Buckley, Antonio Abbate
Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine. IL-1 was implicated as a cardiodepressant factor in septic shock, and subsequent pre-clinical and clinical research has defined important roles for IL-1 in atherosclerosis, acute myocardial infarction (AMI), and heart failure (HF). IL-1 promotes the formation of the atherosclerotic plaque and facilitates its progression and complication. In a large phase III clinical trial of stable patients with prior AMI, blocking IL-1 activity using a monoclonal antibody prevented recurrent atherothrombotic cardiovascular events...
June 7, 2018: European Heart Journal
https://www.readbyqxmd.com/read/29568273/regular-aerobic-resistance-and-cross-training-exercise-prevents-reduced-vascular-function-following-a-high-sugar-or-high-fat-mixed-meal-in-young-healthy-adults
#11
Emon K Das, Pui Y Lai, Austin T Robinson, Joan Pleuss, Mohamed M Ali, Jacob M Haus, David D Gutterman, Shane A Phillips
The postprandial state can negatively influence flow mediated dilation (FMD), a predictor of atherosclerosis and cardiovascular disease. This investigation was designed to determine the effect of regular aerobic and/or resistance exercise on postprandial FMD after a high sugar or high fat mixed meal. Forty-five healthy participants were recruited from one of four groups: lean sedentary (SED), runners, weight lifters, and cross-trainers. Participants were randomly crossed over to a high sugar meal (HSM) and a high fat mixed meal (HFMM; both fat and carbohydrate)...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29534238/targeting-epigenetic-dna-and-histone-modifications-to-treat-kidney-disease
#12
Miguel Fontecha-Barriuso, Diego Martin-Sanchez, Olga Ruiz-Andres, Jonay Poveda, Maria Dolores Sanchez-Niño, Lara Valiño-Rivas, Marta Ruiz-Ortega, Alberto Ortiz, Ana Belén Sanz
Epigenetics refers to heritable changes in gene expression patterns not caused by an altered nucleotide sequence, and includes non-coding RNAs and covalent modifications of DNA and histones. This review focuses on functional evidence for the involvement of DNA and histone epigenetic modifications in the pathogenesis of kidney disease and the potential therapeutic implications. There is evidence of activation of epigenetic regulatory mechanisms in acute kidney injury (AKI), chronic kidney disease (CKD) and the AKI-to-CKD transition of diverse aetiologies, including ischaemia-reperfusion injury, nephrotoxicity, ureteral obstruction, diabetes, glomerulonephritis and polycystic kidney disease...
March 9, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29519347/10-year-resource-utilization-and-costs-for-cardiovascular-care
#13
Leslee J Shaw, Abhinav Goyal, Christina Mehta, Joe Xie, Lawrence Phillips, Anita Kelkar, Joseph Knapper, Daniel S Berman, Khurram Nasir, Emir Veledar, Michael J Blaha, Roger Blumenthal, James K Min, Reza Fazel, Peter W F Wilson, Matthew J Budoff
BACKGROUND: Cardiovascular disease (CVD) imparts a heavy economic burden on the U.S. health care system. Evidence regarding the long-term costs after comprehensive CVD screening is limited. OBJECTIVES: This study calculated 10-year health care costs for 6,814 asymptomatic participants enrolled in MESA (Multi-Ethnic Study of Atherosclerosis), a registry sponsored by the National Heart, Lung, and Blood Institute, National Institutes of Health. METHODS: Cumulative 10-year costs for CVD medications, office visits, diagnostic procedures, coronary revascularization, and hospitalizations were calculated from detailed follow-up data...
March 13, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29507857/importance-of-physical-capacity-and-the-effects-of-exercise-in-heart-transplant-recipients
#14
REVIEW
Marianne Yardley, Lars Gullestad, Kari Nytrøen
One of the most important prognostic factors in heart failure patients is physical capacity. Patients with very poor physical performance and otherwise eligible, may be listed as candidates for heart transplantation (HTx). After such surgery, life-long immunosuppression therapy is needed to prevent rejection of the new heart. The dark side of immunosuppression is the increased risk of infections, kidney failure, cancer and advanced atherosclerosis (cardiac allograft vasculopathy), with the two latter conditions as the main causes of later mortality...
February 24, 2018: World Journal of Transplantation
https://www.readbyqxmd.com/read/29495958/renal-artery-dissection-in-a-patient-with-degenerative-scoliosis-a-rare-complication-caused-by-lumbar-vertebra-osteophyte
#15
Mehmet Beyazal, Münevver Serdaroglu Beyazal, Ekrem Kara, Hatice Beyazal Polat, Fatma Beyazal Çeliker, Şaban Ergene
Isolated spontaneous renal artery dissection (RAD) without known trauma is rare, and its etiology has not been determined. However, notable risk factors including hypertension, strenuous exercise, connective tissue disorders, atherosclerosis, extracorporeal shock wave lithotripsy, and cocaine abuse have been reported. To the best of our knowledge, isolated RAD caused by lumbar vertebra osteophytes in patients with degenerative lumbar scoliosis has not been reported in the literature. In this article, we present a case of RAD caused by lumbar vertebra osteophyte in a patient with degenerative scoliosis and discuss the management of the disease...
May 2018: Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29472066/serum-levels-of-irisin-predict-short-term-outcomes-in-ischemic-stroke
#16
Huisheng Wu, Peipei Guo, Zhao Jin, Xinyi Li, Xin Yang, Chaoliang Tang, Yanlin Wang, Jianjuan Ke
OBJECTIVE: Irisin is a 112-amino acid peptide found in rat and human skeletal muscle after exercise. Previous studies had suggested that higher circulating irisin levels were associated with an increased risk of vascular atherosclerosis and cardiovascular diseases. In this study, we determined irisin levels in serum, and investigated their associations with functional outcomes in a 3-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). METHODS: From September 2015 to December 2016, consecutive first-ever AIS patients admitted to the Department of Emergency of our hospital were identified...
February 19, 2018: Cytokine
https://www.readbyqxmd.com/read/29459517/reduced-lung-function-and-cerebral-small-vessel-disease-in-japanese-men-the-shiga-epidemiological-study-of-subclinical-atherosclerosis-sessa
#17
Ruriko Seto-Yukimura, Emiko Ogawa, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Kazuhiko Nozaki, Akira Fujiyoshi, Katsuyuki Miura, Yasutaka Nakano, Hirotsugu Ueshima
AIM: We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population. METHODS: We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation...
February 16, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29458301/measurement-of-peripheral-blood-flow-in-patients-with-peripheral-artery-disease-methods-and-considerations
#18
Dereck L Salisbury, Rebecca Jl Brown, Ulf G Bronas, Laura N Kirk, Diane Treat-Jacobson
Peripheral artery disease (PAD) is a manifestation of generalized atherosclerosis which results in hemodynamic compromise of oxygen and substrate delivery to the lower extremity skeletal muscles. Hemodynamic assessments are vital in PAD diagnosis and in the evaluation of strategies aimed at treating claudication (i.e. exercise training, revascularization, and pharmacological agents). Venous occlusion plethysmography (VOP) is a century-old, non-invasive technique used to quantify limb blood flow and has been used to evaluate hemodynamic compromise in patients with PAD...
April 2018: Vascular Medicine
https://www.readbyqxmd.com/read/29455788/presence-of-coronary-artery-disease-in-diabetic-and-non-diabetic-south-asian-immigrants
#19
Sunita Dodani, Gyanendra K Sharma
INTRODUCTION: South Asian Immigrants (SAIs) are the second fastest growing Asian immigrant population in the US, and at a higher risk of type 2 diabetes (diabetes) and coronary artery disease (CAD) than the general US population. OBJECTIVES: We sought to determine in SAIs the; 1) the prevalence of CAD risk factors in diabetics and non-diabetics; and b) the high possibility of CAD in diabetic SAIs. We also assessed the prevalence of sub-clinical CAD in both diabetics and non-diabetics SAIs using common carotid artery Intima-media thickness (CIMT) as a surrogate marker for atherosclerosis...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29433015/effect-of-strenuous-exercise-on-mediators-of-inflammation-in-patients-with-coronary-artery-disease
#20
Joanna Cwikiel, Ingebjørg Seljeflot, Eivind Berge, Ida Unhammer Njerve, Hilde Ulsaker, Harald Arnesen, Arnljot Flaa
BACKGROUND: Coronary artery disease (CAD) is considered a low-grade inflammatory disease. We aimed to identify effects of short-term strenuous exercise on mediators of systemic inflammation, endothelial and platelet activation in patients with angiographically verified CAD. We hypothesized that a more pronounced inflammatory response would be present in patients with CAD than in those without CAD. METHODS: In subjects with symptoms indicative of stable CAD, an exercise stress test on a bicycle ergometer was performed...
May 2018: Cytokine
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