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https://www.readbyqxmd.com/read/28722106/anti-inflammatory-effects-of-exercise-role-in-diabetes-and-cardiovascular-disease
#1
REVIEW
Bente Klarlund Pedersen
BACKGROUND: Persistent inflammation is involved in the pathogenesis of chronic diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). AIMS: The aim of this review was to provide the reader with an update of the mechanisms whereby exercise-induced cytokines may impact cardiometabolic diseases. RESULTS: Evidence exists that interleukin (IL)-1β is involved in pancreatic β-cell damage, whereas TNF-α is a key molecule in peripheral insulin resistance...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28662008/-evaluation-of-oxidative-reduction-markers-of-blood-in-patients-with-acute-coronary-syndromes-acs-subjected-to-cardiac-rehabilitation
#2
Anna Mejer-Barczewska, Joanna Kapusta, Małgorzata Godala, Edward Kowalczyk, Robert Irzmański, Jan Kowalski
Role in the pathogenesis of atherosclerosis play a reactive oxygen species. In the case of disturbance of dynamic balance between their production and antioxidant defense mechanisms comes to undesirable consequences - oxidative stress. Excessive exercise can, among others, disrupting the balance. AIM: The aim of the study was to evaluate the exponents of the processes of oxidation - reduction of blood in patients with ACS undergoing rehabilitation in a hospital setting. MATERIALS AND METHODS: The study included 25 patients after ACS STEMI, including 19 men and 6 women, aged 51...
June 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28653394/ranolazine-reduces-repolarization-heterogeneity-in%C3%A2-symptomatic-patients-with-diabetes-and-non-flow-limiting-coronary-artery-stenosis
#3
Ederson Evaristo, Fernando G Stocco, Nishant R Shah, Michael K Cheezum, Jon Hainer, Courtney Foster, Bruce D Nearing, Marcelo Di Carli, Richard L Verrier
BACKGROUND: Experimental evidence suggests that ranolazine decreases susceptibility to ischemia-induced arrhythmias independent of effects on coronary artery blood flow. OBJECTIVE: In symptomatic diabetic patients with non-flow-limiting coronary artery stenosis with diffuse atherosclerosis and/or microvascular dysfunction, we explored whether ranolazine reduces T-wave heterogeneity (TWH), an electrocardiographic (ECG) marker of arrhythmogenic repolarization abnormalities shown to predict sudden cardiac death...
June 27, 2017: Annals of Noninvasive Electrocardiology
https://www.readbyqxmd.com/read/28616545/assessment-of-various-parameters-using-simple-non-invasive-tests-in-patients-with-cardiovascular-diseases-with-or-without-cardiac-rehabilitation
#4
Takashi Ueda, Shin-Ichiro Miura, Kanta Fujimi, Toshihisa Ishida, Takuro Matsuda, Masaomi Fujita, Yoshiyuki Ura, Kouji Kaino, Maya Sakamoto, Tomoe Horita, Tadaaki Arimura, Yuhei Shiga, Takashi Kuwano, Ken Kitajima, Keijiro Saku
Cardiac rehabilitation (CR) improves cardiac function and exercise capacity in patients with cardiovascular disease (CVD). Simpler techniques are needed for use by physicians in the examination room to assess the usefulness of CR. We enrolled 46 consecutive CVD patients in a CR program (CR group) and prospectively followed them for 3 months. We compared them to 18 age-, gender- and body mass index-matched CVD patients without CR (non-CR group). Various parameters were measured at baseline and after 3 months using 3 simple non-invasive tests: severity of atherosclerosis [arterial velocity pulse index and arterial pressure volume index (API)] were determined using PASESA®, an autonomic nerve total activity amount index and a coefficient of variation of the R-R interval (CVRR) were determined using eHEART®, and peripheral resistance index, pressure rate product, stroke volume and cardiac index were determined using nico®]...
September 2016: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/28608819/the-therapeutic-potential-of-anti-inflammatory-exerkines-in-the-treatment-of-atherosclerosis
#5
REVIEW
Megan Yu, Sheng-Feng Tsai, Yu-Min Kuo
Although many cardiovascular (CVD) medications, such as antithrombotics, statins, and antihypertensives, have been identified to treat atherosclerosis, at most, many of these therapeutic agents only delay its progression. A growing body of evidence suggests physical exercise could be implemented as a non-pharmacologic treatment due to its pro-metabolic, multisystemic, and anti-inflammatory benefits. Specifically, it has been discovered that certain anti-inflammatory peptides, metabolites, and RNA species (collectively termed "exerkines") are released in response to exercise that could facilitate these benefits and could serve as potential therapeutic targets for atherosclerosis...
June 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28590143/combined-exercise-training-reduces-blood-pressure-arterial-stiffness-and-insulin-resistance-in-obese-prehypertensive-adolescent-girls
#6
Won-Mok Son, Ki-Dong Sung, Leena P Bharath, Kong-Jib Choi, Song-Young Park
Childhood obesity is strongly linked to pathological processes for cardiovascular diseases in later adulthood. Obese adolescent girls with high blood pressure (BP) are reported to have increased arterial stiffness, which is associated with the development of hypertension and atherosclerosis. The present study sought to examine the impact of combined resistance and aerobic exercise (CRAE) training on BP, brachial-ankle pulse wave velocity (baPWV), insulin resistance (IR), and body composition in obese prehypertensive girls...
June 7, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28574286/changes-of-intima-media-thickness-in-marathon-runners-a-mid-term-follow-up
#7
Jan Müller, Valeria Dahm, Elke S Lorenz, Axel Pressler, Bernhard Haller, Viola Grabs, Martin Halle, Johannes Scherr
Objective Carotid intima-media thickness (IMT) is used to assess cardiovascular risk and progression of atherosclerosis. It is known that regular physical activity of moderate intensity has beneficial effects on the vasculature. However, it is still discussed controversially whether prolonged exercise, including participation in exhaustive competitive sports such as long-distance races, has also beneficial effects or might even be harmful regarding the cardiovascular system. Patients and methods Thirty-eight male marathon runners (45...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28548953/from-rapalogs-to-anti-aging-formula
#8
Mikhail V Blagosklonny
Inhibitors of mTOR, including clinically available rapalogs such as rapamycin (Sirolimus) and Everolimus, are gerosuppressants, which suppress cellular senescence. Rapamycin slows aging and extends life span in a variety of species from worm to mammals. Rapalogs can prevent age-related diseases, including cancer, atherosclerosis, obesity, neurodegeneration and retinopathy and potentially rejuvenate stem cells, immunity and metabolism. Here, I further suggest how rapamycin can be combined with metformin, inhibitors of angiotensin II signaling (Losartan, Lisinopril), statins (simvastatin, atorvastatin), propranolol, aspirin and a PDE5 inhibitor...
May 30, 2017: Oncotarget
https://www.readbyqxmd.com/read/28529328/perivascular-adipose-tissue-epiphenomenon-or-local-risk-factor
#9
REVIEW
K Schäfer, I Drosos, S Konstantinides
Obesity is associated with an increased cardiovascular risk, but the mechanisms underlying the link between increased body weight and vascular disease are incompletely understood. Over the past 15 years, perivascular adipose tissue has emerged as active component of the vessel wall involved in vascular homeostasis. However, perivascular adipose tissue can adopt detrimental properties under the influence of obesity and other factors and contribute actively to the pathophysiology of cardiovascular disease. Conversely, changes of the vessel wall may negatively affect perivascular adipose tissue qualities...
May 22, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28528154/impact-of-exercise-on-the-relationship-between-cac-scores%C3%A2-and-all-cause-mortality
#10
Yoav Arnson, Alan Rozanski, Heidi Gransar, Sean W Hayes, John D Friedman, Louise E J Thomson, Daniel S Berman
OBJECTIVES: This study aims to assess the correlations among coronary artery calcium (CAC), self-reported exercise, and mortality in asymptomatic patients. BACKGROUND: The interaction between reported exercise habits and CAC scores for predicting clinical risk is not yet well known. METHODS: We followed 10,690 asymptomatic patients who underwent CAC scanning. Patients were divided into 4 groups based on a single-item self-reported exercise...
May 11, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28521867/effect-of-a-single-bout-of-aerobic-exercise-on-high-fat-meal-induced-inflammation
#11
RANDOMIZED CONTROLLED TRIAL
Kelly N Z Fuller, Corey M Summers, Rudy J Valentine
BACKGROUND AND AIMS: Chronic low-grade inflammation is involved in the development of metabolic disorders including atherosclerosis, type 2 diabetes (T2D) and metabolic syndrome. Aerobic exercise has been shown to be anti-inflammatory and attenuate postprandial blood lipids, however, the effect of exercise on postprandial inflammation remains unclear. The aim of this study was to determine the protective effect of a single bout of aerobic exercise against postprandial lipemia and peripheral blood mononuclear cell (PBMC) inflammation and to evaluate associations with changes in the energy-sensing enzyme, AMP-activated protein kinase (AMPK)...
June 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28515794/influence-of-a-home-based-exercise-program-on-the-urine-ph-in-elderly-female-subjects-a-secondary-analysis-of-a-randomized-controlled-trial
#12
Yuichiro Nishida, Keitaro Tanaka, Megumi Hara, Noriko Hirao, Hiroaki Tanaka, Takuro Tobina, Masaharu Ikeda, Hiroshi Yamato, Masanori Ohta
BACKGROUND: A low urine pH is a characteristic metabolic feature of metabolic syndrome and type 2 diabetes. The purpose of the current study was to investigate the effects of a 12-week home-based bench step exercise on the urine pH status of elderly female subjects. METHODS: The current study is a secondary analysis of a randomized controlled trial (RCT) in which 59 postmenopausal female subjects were randomized to either the exercise group (n = 29) or the control group (n = 30)...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28473401/ranolazine-in-symptomatic-diabetic-patients-without-obstructive-coronary-artery-disease-impact-on-microvascular-and-diastolic-function
#13
Nishant R Shah, Michael K Cheezum, Vikas Veeranna, Stephen J Horgan, Viviany R Taqueti, Venkatesh L Murthy, Courtney Foster, Jon Hainer, Karla M Daniels, Jose Rivero, Amil M Shah, Peter H Stone, David A Morrow, Michael L Steigner, Sharmila Dorbala, Ron Blankstein, Marcelo F Di Carli
BACKGROUND: Treatments for patients with myocardial ischemia in the absence of angiographic obstructive coronary artery disease are limited. In these patients, particularly those with diabetes mellitus, diffuse coronary atherosclerosis and microvascular dysfunction is a common phenotype and may be accompanied by diastolic dysfunction. Our primary aim was to determine whether ranolazine would quantitatively improve exercise-stimulated myocardial blood flow and cardiac function in symptomatic diabetic patients without obstructive coronary artery disease...
May 4, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28463859/adiponectin-lipids-and-atherosclerosis
#14
Niki Katsiki, Christos Mantzoros, Dimitri P Mikhailidis
PURPOSE OF REVIEW: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases...
August 2017: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/28462118/insulin-resistance-vascular-function-and-exercise
#15
REVIEW
Moon-Hyon Hwang, Sewon Lee
Insulin resistance associated with metabolic syndrome and Type 2 diabetes mellitus is an epidemic metabolic disorder, which increases the risk of cardiovascular complications. Impaired vascular endothelial function is an early marker for atherosclerosis, which causes cardiovascular complications. Both experimental and clinical studies indicate that endothelial dysfunction in vasculatures occurs with insulin resistance. The associated physiological mechanisms are not fully appreciated yet, however, it seems that augmented oxidative stress, a physiological imbalance between oxidants and antioxidants, in vascular cells is a possible mechanism involved in various vascular beds with insulin resistance and hyperglycemia...
September 2016: Integrative medicine research
https://www.readbyqxmd.com/read/28457197/management-of-cardiovascular-risk-in-systemic-lupus-erythematosus-a-systematic-review
#16
C Andrades, C Fuego, S Manrique-Arija, A Fernández-Nebro
Systemic lupus erythematosus is associated with accelerated atherosclerosis and increased risk of cardiovascular complications. The aim of this study was to review the effectiveness of interventions for primary and secondary prevention of cardiovascular events and mortality and to review the effectiveness of interventions for cardiovascular risk factor reduction in systemic lupus erythematosus patients. A systematic review was conducted. Electronic databases Medline and Embase (1961-2015) were searched. Nineteen articles met the inclusion criteria and were selected...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28450347/the-relationship-between-lifelong-exercise-volume-and-coronary-atherosclerosis-in-athletes
#17
Vincent L Aengevaeren, Arend Mosterd, Thijs L Braber, Niek H J Prakken, Pieter A Doevendans, Diederick E Grobbee, Paul D Thompson, Thijs M H Eijsvogels, Birgitta K Velthuis
Background -Higher levels of physical activity are associated with a lower risk of cardiovascular events. Nevertheless, there is debate on the dose-response relationship of exercise and CVD outcomes and whether high volumes of exercise may accelerate coronary atherosclerosis. We aimed to determine the relationship between lifelong exercise volumes and coronary atherosclerosis. Methods -Middle aged men engaged in competitive or recreational leisure sports underwent a non-contrast and contrast-enhanced computed tomography scan to assess coronary artery calcification (CAC) and plaque characteristics...
April 27, 2017: Circulation
https://www.readbyqxmd.com/read/28437655/peripheral-artery-disease-redox-signaling-oxidative-stress-basic-and-clinical-aspects
#18
REVIEW
Sebastian Steven, Andreas Daiber, Jörn F Dopheide, Thomas Münzel, Christine Espinola-Klein
Reactive oxygen and nitrogen species (ROS and RNS, e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. At higher concentrations, ROS and RNS lead to oxidative stress and oxidative damage of biomolecules (e.g. via formation of peroxynitrite, fenton chemistry). Peripheral artery disease (PAD) is characterized by severe ischemic conditions in the periphery leading to intermittent claudication and critical limb ischemia (end stage)...
August 2017: Redox Biology
https://www.readbyqxmd.com/read/28432115/effects-of-exercise-on-vascular-function-structure-and-health-in-humans
#19
Daniel J Green, Kurt J Smith
Physical activity has profound impacts on the vasculature in humans. Acute exercise induces immediate changes in artery function, whereas repeated episodic bouts of exercise induce chronic functional adaptation and, ultimately, structural arterial remodeling. The nature of these changes in function and structure are dependent on the characteristics of the training load and may be modulated by other factors such as exercise-induced inflammation and oxidative stress. The clinical implications of these physiological adaptations are profound...
April 21, 2017: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/28372866/increased-interarm-blood-pressure-difference-is-associated-with-autonomic-dysfunction-and-atherosclerosis-in-patients-with-chest-pain-and-no-history-of-coronary-artery-disease
#20
Hui-Jeong Hwang, Il Suk Sohn, Dong-Hee Kim, Chang-Bum Park, Jin-Man Cho, Chong-Jin Kim
OBJECTIVES: Interarm blood pressure (BP) difference has been reported to be associated with atherosclerosis and increased cardiovascular death. We were to investigate associations of interarm systolic blood pressure (SBP) difference with heart rate recovery (HRR) after exercise, an index of autonomic function, and carotid atherosclerotic markers, and to evaluate the association of interarm SBP difference with concurrent coronary artery disease (CAD). METHODS: A total of 995 consecutive patients who underwent treadmill stress echocardiography with chest pain but no history of CAD were enrolled...
August 15, 2017: International Journal of Cardiology
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