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Sodium nitrite

Faqian Sun, KeKe Xiao, Wenyu Zhu, Nipuna Withanage, Yan Zhou
In this study, nitrite was added into sludge during freezing process to evaluate its role in waste activated sludge (WAS) solubilization and effect on sludge dewatering characteristics. The results showed that the introduction of 100 mg L-1 of nitrite could increase dissolved organic carbon (DOC) concentration from 29.5 to 48.8 mg DOC g-1 VSS under freezing conditions. More DOC was released with the increase of nitrite concentration. Freezing temperature, or freezing speed, also played a role in sludge solubilization...
November 30, 2017: Water Research
Leonardo Jensen, Elida Neri, Vinicius Bassaneze, Nathalia Corrêa De Almeida Oliveira, Rafael Dariolli, Thiago Lauro Turaça, Débora Levy, Douglas Veronez, Mariana Sacrini Ayres Ferraz, Adriano Mesquita Alencar, Sérgio Paulo Bydlowski, Idágene Aparecida Cestari, José Eduardo Krieger
Neonatal cardiomyocytes are instrumental for disease modeling, but the effects of different cell extraction methods on basic cell biological processes remain poorly understood. We assessed the influence of two popular methods to extract rat neonatal cardiomyocytes, Pre-plating (PP) and Percoll (PC) on cell structure, metabolism, and function. Cardiomyocytes obtained from PP showed higher gene expression for troponins, titin, and potassium and sodium channels compared to PC. Also, PP cells displayed higher levels of troponin I protein...
December 8, 2017: Journal of Cellular Physiology
Helen Christou, Hannes Hudalla, Zoe Michael, Evgenia Filatava, Jun Li, Minglin Zhu, Jose Possomato-Vieira, Carlos Dias-Junior, Stella Kourembanas, Raouf A Khalil
Pulmonary vasoreactivity could determine the responsiveness to vasodilators and in turn the prognosis of pulmonary hypertension (PH). We hypothesized that pulmonary vasoreactivity is impaired, and examined the underlying mechanisms, in the sugen-hypoxia rat model of severe PH. Male Sprague-Dawley rats were injected with sugen (20 mg/kg sc) and exposed to hypoxia (9% O2) for 3 weeks followed by 4 weeks in normoxia (Su/Hx), or treated with sugen alone (Su) or hypoxia alone (Hx) or neither (Nx). After hemodynamic measurements, the heart was assessed for right ventricular hypertrophy (Fulton's Index), the pulmonary artery, aorta and mesenteric arteries were isolated for vascular function studies, and contractile markers were measured in pulmonary artery using quantitative PCR...
December 6, 2017: Journal of Pharmacology and Experimental Therapeutics
Florian Mauffrey, Alexandra Cucaita, Philippe Constant, Richard Villemur
Background: Methylophaga nitratireducenticrescens strain JAM1 is a methylotrophic, marine bacterium that was isolated from a denitrification reactor treating a closed-circuit seawater aquarium. It can sustain growth under anoxic conditions by reducing nitrate ([Formula: see text]) to nitrite ([Formula: see text]). These physiological traits are attributed to gene clusters that encode two dissimilatory nitrate reductases (Nar). Strain JAM1 also contains gene clusters encoding two nitric oxide (NO) reductases and one nitrous oxide (N2O) reductase, suggesting that NO and N2O can be reduced by strain JAM1...
2017: PeerJ
Cameron Dezfulian, Michele Olsufka, Deborah Fly, Sue Scruggs, Rose Do, Charles Maynard, Graham Nichol, Francis Kim
BACKGROUND: Patients resuscitated from cardiac arrest have brain and cardiac injury. Recent animal studies suggest that the administration of sodium nitrite after resuscitation from 12minutes of asystole limits acute cardiac dysfunction and improves survival and neurologic outcomes. It has been hypothesized that low doses of IV sodium nitrite given during resuscitation of out of hospital cardiac arrest (OHCA) will improve survival. Low doses of sodium nitrite (e.g., 9.6mg of sodium nitrite) are safe in healthy individuals, however the effect of nitrite on blood pressure in resuscitated cardiac arrest patients is unknown...
November 23, 2017: Resuscitation
Dong Ju Kim, Joo-Hee Park, Marth Kim, Choul Yong Park
BACKGROUND: To investigate the antibiofilm efficacy of nitric oxide (NO) on soft contact lenses. METHODS: Nitrite (NO precursor) release from various concentrations (0-1000 μM) of sodium nitrite (NaNO2, NO donor) was measured by Griess Assay. Cell viability assay was performed using human corneal epithelial cell under various concentration (0-1000 μM) of NaNO2. Biofilm formation on soft contact lenses was achieved by adding Staphylococcus aureus or Pseudomonas aeruginosa to the culture media...
November 21, 2017: BMC Ophthalmology
Yafei Wang, Xin Song, Xia Yue, Hong Su, Yuanliang Gu, Linda Bowman, Min Ding, Baobo Zou, Jinshun Zhao, Xialu Lin
OBJECTIVE: This research was aimed to investigate the correct dose of nitrite that would act as a protection against the ischemic effects induced by acute myocardial infarction (AMI). METHODS: Mice were randomly divided into a sham-operation group (sham), an AMI operation group (AMI), and a nitrite pretreatment+AMI operation group (N+AMI). Seven days before the AMI operation, mice in the N+AMI group were pretreated with sodium nitrite in drinking water. RESULTS: One week after the AMI operation, serum lactate dehydrogenase (LDH) and creatine kinase (CK) activities in both AMI and N+AMI group were significantly higher than those in the sham group, but there were no significant differences between AMI and N+AMI mice...
November 2017: Anatolian Journal of Cardiology
Talambedu Usha, Sushen Pradhan, Arvind Kumar Goyal, Shanmugarajan Dhivya, H P Prashanth Kumar, Manoj Kumar Singh, Neelu Joshi, Bharat Chandra Basistha, K R Siddalinga Murthy, Saravanakumar Selvaraj, Sushil Kumar Middha
Objective: The main aim of this scientific report was to investigate a series of phytochemicals in silico and the pharmacology of four plants found at higher altitude in the ginger family, Zingiberaceae (incl. Costaceae) from North-East India, particularly Sikkim. First, the goal was to determine the biological activities of the four herbs (used under Zingiberaceae family) using antioxidant assays to identify the best species. Second, previously reported compounds in litero were subsequently screened for their anticancerous activities using in silico methods...
October 2017: Pharmacognosy Magazine
Dinesh Dhingra, Kapil Soni
Boldine, a bioactive compound, has been reported to be neuroprotective, but its effect on learning and memory has not been explored. So, the present study was aimed to study the effect of boldine on the learning and memory of the Swiss albino male young and aged mice. Boldine (1.5, 3 and 6mg/kg, po) and physostigmine salicylate (0.1mg/kg, ip) were administered to separate groups of mice for 7 successive days. Morris water maze was utilized as a behavioural model to study the effect of drugs on learning and memory of mice...
November 6, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Gregory W Sluggett, Todd Zelesky, Evan M Hetrick, Yelizaveta Babayan, Steven W Baertschi
Accelerated stability studies of pharmaceutical products are commonly conducted at various combinations of temperature and relative humidity (RH). The RH of the sample environment can be controlled to set points using humidity-controlled stability chambers or via storage of the sample in a closed container in the presence of a saturated aqueous salt solution. Herein we report an unexpected N-nitrosation reaction that occurs upon storage of carvedilol- or propranolol-excipient blends in a stability chamber in the presence of saturated sodium nitrite (NaNO2) solution to control relative humidity (∼60% RH)...
October 29, 2017: Journal of Pharmaceutical and Biomedical Analysis
W L Liu, C B Zhang, W J Han, M Guan, S Y Liu, Y Ge, J Chang
To control potential fungal denitrification rate (PFDR) in vertical flow simulated wetlands (VFSW) microcosms, thirty VFSW microcosms were established and planted with three plant species richness levels (i.e. unplanted, monoculture, and four-species polyculture treatment), and effects of carbon, nitrogen and pH amendments on the PFDR were investigated using a room-incubating method. Among seven carbon compounds, sodium citrate, glycerol, glucose and sodium succinate were more effective in enhancing PFDRs. These enhanced effects were dependant on a given species richness level...
November 7, 2017: Bulletin of Environmental Contamination and Toxicology
Rosanne J H C G Beijers, Stephanie M D Huysmans, Coby van de Bool, Boris R M Kingma, Lex B Verdijk, Luc J C van Loon, Steven J R Meex, Harry R Gosker, Annemie M W J Schols
BACKGROUND & AIMS: Many COPD patients have a reduced exercise capacity and mechanical efficiency and are at increased cardiometabolic risk. This study aimed to assess acute and 7-days effects of dietary nitrate on mechanical efficiency, exercise performance and cardiac biomarkers in patients with COPD. METHODS: This double-blind, randomized cross-over placebo controlled trial included 20 mild-to-moderate COPD patients (66.6 ± 7.5 years) with moderate exercise impairments and decreased mechanical efficiency, normal BMI (26 ± 3 kg/m(2)) but high prevalence of abdominal obesity (83...
October 31, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Qiang Chu, Yiying Zhao, Xuer Shi, Wen Han, Yanzhen Zhang, Xiaodong Zheng, Jing Zhu
To address the need for a high throughput toxicity test in the modern food industry, an in vivo-like 3-D cell model was constructed in this study to provide an alternative to controversial long-term animal models and to improve the sensitivity and accuracy of the traditional monolayer model. The model formed cell cylindroids within polyvinylidene fluoride (PVDF) hollow fibers and therefore mimicked the microenvironment of liver tissue. Microscopy methods were used, and liver-specific functions were measured to demonstrate the superiority of the model compared to the monolayer model, as well as to optimize the model for best cell performances...
November 1, 2017: Scientific Reports
Jeppe B Rosenbæk, Bodil G Hornstrup, Andreas N Jørgensen, Jesper Mortensen, Erling B Pedersen, Jesper N Bech
OBJECTIVE: Nitric oxide is a key player in regulating vascular tone. Impaired endothelial nitric oxide synthesis plays an important role in hypertension. Replenishing of nitric oxide by sodium nitrite (NaNO2) has not been investigated in patients with essential hypertension (EHT). We aimed to determine the effects of NaNO2 on blood pressure (BP) and renal sodium and water regulation in patients with EHT compared with healthy control study participants (CON). METHODS: In a placebo-controlled, crossover study, we infused 240 μg NaNO2/kg/h or isotonic saline for 2 h in 14 EHT and 14 CON...
October 23, 2017: Journal of Hypertension
Maozhong Miao, Yi Luo, Huaping Xu, Mengchao Jin, Zhengkai Chen, Jianfeng Xu, Hongjun Ren
The tunable nucleophilic nitration of 3-cyclopropylideneprop-2-en-1-ones with cheap sodium nitrite is described. This transformation proceeds with the assistance of a strained cyclopropane ring and allows for a divergent route to various synthetically useful β,γ-dinitro or γ-mononitro adducts in high yields with exclusive regio- and stereoselectivity. Additionally, a wide array of valuable functionalized N-unprotected pyrroles is achieved from the resulting β,γ-dinitro compounds via reductive cyclization strategy...
October 30, 2017: Journal of Organic Chemistry
Sabrine Sellimi, Abdelkarim Benslima, Ghada Ksouda, Veronique Barragan Montero, Mohamed Hajji, Moncef Nasri
Background Nitrite salts are still common additives in the meat industry. The present study provides a first approach on the employment of the lyophilized aqueous extract (WE) of the Tunisian seaweed Cystoseira barbata for the quality enhancement of turkey meat sausage. Methods WE was supplemented as a natural antioxidant agent to investigate its effectiveness in delaying lipid oxidation turkey meat sausages containing reduced amounts of sodium nitrites. Results On storage day 5, all concentrations of WE (0...
October 21, 2017: Journal of Complementary & Integrative Medicine
Valdemir Rodrigues, Joan Estrany, Mauricio Ranzini, Valdir de Cicco, José Mª Tarjuelo Martín-Benito, Javier Hedo, Manuel E Lucas-Borja
Stream water quality is controlled by the interaction of natural and anthropogenic factors over a range of temporal and spatial scales. Among these anthropogenic factors, land cover changes at catchment scale can affect stream water quality. This work aims to evaluate the influence of land use and seasonality on stream water quality in a representative tropical headwater catchment named as Córrego Água Limpa (Sao Paulo, Brasil), which is highly influenced by intensive agricultural activities and urban areas...
October 17, 2017: Science of the Total Environment
Fariheen Aisha Ansari, Riaz Mahmood
Sodium nitrite (NaNO2 ) is widely used in the food industry as a preservative and colorant in meat and fish products. Industrialization and improper agricultural practices have greatly increased human exposure to high nitrite levels, mainly through contaminated drinking water, causing various health disorders. We have investigated the protective effect of carnosine (CAR) and N-acetyl cysteine (NAC) on NaNO2 -induced toxicity in rat blood. CAR is a bioactive dipeptide found in mammalian muscle while NAC is a synthetic sulfhydryl amino acid and an important precursor of glutathione...
October 20, 2017: Cell Biology International
Kuang-En Chu, Yao Fong, David Wang, Chao Fuh Chen, Diana Yu-Wung Yeh
OBJECTIVE: Acute lung injury (ALI) is one of the most common extra-pancreatic complications of acute pancreatitis. In this study, we examined the protective effect of protease inhibitor aprotinin and a matrix metalloproteinase inhibitor (MMPi) on pulmonary inflammation in rats with severe pancreatitis-associated ALI. METHOD: A rat model of acute pancreatitis (AP) was established by injecting sodium glycodeoxycholate (GDOC) into the pancreatic duct. Pharmacological interventions included pretreatment with a protease inhibitor aprotinin (10mg/kg) and a matrix metalloproteinase inhibitor (MMPi, 100g/kg)...
October 6, 2017: Immunobiology
Teerapat Yingchoncharoen, Teewin Rakyhao, Suporn Chuncharunee, Piyamitr Sritara, Pavit Pienvichit, Kittiphong Paiboonsukwong, Piyadon Sathavorasmith, Kanjana Sirirat, Thanaporn Sriwantana, Sirada Srihirun, Nathawut Sibmooh
Pulmonary hypertension is a life-threatening complication in β-thalassemia. Inhaled sodium nitrite has vasodilatory effect on pulmonary vasculature. However, its effect on pulmonary artery pressure (PAP) in β-thalassemia subjects with pulmonary hypertension has never been reported. In this study, we investigated the change in PAP during inhalation of sodium nitrite in 5 β-thalassemia patients. We demonstrated that sodium nitrite administered by nebulization rapidly decreased PAP as measured by echocardiography and right heart catheterization...
September 27, 2017: Nitric Oxide: Biology and Chemistry
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