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Sodium nitrite

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https://www.readbyqxmd.com/read/27905382/-complexes-of-nitric-oxide-with-hemoglobin-and-paramagnetic-metalloenzymes-in-the-brain-and-blood-of-mammals-after-intermittent-hypoxia
#1
Z V Kuropteva, V P Reutov, L M Baider, A L Krushinsky
AIM: To investigate an effect of hypoxia on the formation of nitric oxide (NO) in the brain and blood of rats and an influence of L-NNA, the NO-synthase inhibitor, and sodium nitrite on NO generation in separate and simultaneous introduction of these compounds in the animal body. MATERIAL AND METHODS: Experiments were conducted on 42 rats of Krushinsky-Molodkina (K-M) line without adaptation to hypoxia and short-term adaptation to hypobaric hypoxia. Animals were intraperitoneally injected with sodium nitrite (0...
2016: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/27901641/light-triggered-selective-nitration-of-psbo1-in-isolated-arabidopsis-thylakoid-membranes-is-inhibited-by-photosynthetic-electron-transport-inhibitors
#2
Misa Takahashi, Jun Shigeto, Atsushi Sakamoto, Hiromichi Morikawa
PSBO1 is exclusively nitrated when isolated thylakoid membranes are incubated in a buffer bubbled with nitrogen dioxide (NO2) containing NO2 and nitrite. NO2 is the primary intermediate for this selective nitration. Isolated thylakoid membranes were incubated in NO2-bubbled buffer at 25°C in the light or dark. Protein analysis confirmed the selective nitration of PSBO1. Illumination was found to be essential in PSBO1 nitration. A nitration mechanism whereby nitratable tyrosine residues of PSBO1 are, prior to nitration, selectively photo-oxidized by photosynthetic electron transport to tyrosyl radicals to combine with NO2 to form 3-nitrotyrosine was hypothesized...
November 30, 2016: Plant Signaling & Behavior
https://www.readbyqxmd.com/read/27857537/changes-in-the-physico-chemical-and-microbial-quality-during-the-production-of-past%C3%A4-rma-cured-with-different-levels-of-sodium-nitrite
#3
Muhammet Irfan Aksu, Ebru Erdemir, Neslihan Çakıcı
Pastırma, a dry-cured meat product, is produced from the whole muscle and/or muscles obtained from certain parts of beef and water buffalo carcasses. The purpose of this study was to determine the effects of different levels of sodium nitrite on changes in the physicochemical and microbial quality during the production of pastırma. The changes in residual nitrite, salt, pH, moisture, thiobarbutiric acid reactive substances (TBARS), colour (L*, a*, b*), total aerobic mesophilic bacteria (TAMB), lactic acid bacteria (LAB), Micrococcus/Staphylococcus (M/S), mould-yeast (M-Y), and Enterobacteriaceae counts of pastırma with 0, 50, 100 and 150 ppm sodium nitrite were determined during the production...
October 31, 2016: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/27849257/effects-of-nitrate-intake-on-myocardial-ischemia-reperfusion-injury-in-diabetic-rats
#4
Sajad Jeddi, Saeedeh Khalifi, Mahboubeh Ghanbari, Fatemeh Bageripour, Asghar Ghasemi
BACKGROUND: Coronary artery disease is 2-3 times more common in diabetic individuals. Dietary nitrate/nitrite has beneficial effects in both diabetes and cardiovascular disease. It also has protective effects against myocardial ischemia-reperfusion (IR) injury in healthy animals. However, the effects of nitrate on myocardial IR injury in diabetic rats have not yet been investigated. OBJECTIVE: We examined the effects of dietary nitrate on myocardial IR injury in streptozotocin-nicotinamide-induced diabetic rats...
October 2016: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/27847239/control-of-dimethyl-sulfide-and-dimethyl-disulfide-odors-during-pig-manure-composting-using-nitrogen-amendment
#5
Bing Zang, Shuyan Li, Frederick C Michel, Guoxue Li, Difang Zhang, Yangyang Li
Effects of nitrogen electron acceptors on dimethyl sulfide (Me2S) and dimethyl disulfide (Me2SS) odor emission during composting was investigated. The chemicals and doses used included sodium nitrate (NO3(-) at 10mM, 20mM and 40mM), sodium nitrite (NO2(-) at 10mM, 20mM and 40mM) and sodium nitrite (10mM, 20mM and 40mM) with hexaammonium heptamolybdate tetrahydrate (HHT). The results showed that the addition of these chemicals restricted the emission of Me2S and Me2SS. The emission reduction effect of NO2(-) was greater than NO3(-) at the same dosage...
November 9, 2016: Bioresource Technology
https://www.readbyqxmd.com/read/27834492/single-and-combined-effects-of-beetroot-crystals-and-sodium-bicarbonate-on-4-km-cycling-time-trial-performance
#6
Marcus J Callahan, Evelyn B Parr, John A Hawley, Louise M Burke
When ingested alone, beetroot juice and sodium bicarbonate are ergogenic for high-intensity exercise performance. This study sought to determine the independent and combined effects of these supplements. Eight endurance trained (V̇O2max 65 mL·kg·min(-1)) male cyclists completed four x 4-km time trials (TT) in a double-blind Latin square design supplementing with beetroot crystals (BC) for 3 days (15 g.day(-1) + 15 g 1 h prior to TT, containing 300 mg nitrate per 15 g), bicarbonate (Bi 0.3 g·kg(-1) body mass [BM] in 5 doses every 15 min from 2...
November 11, 2016: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/27812547/acute-hemodynamic-effects-of-inhaled-sodium-nitrite-in-pulmonary-hypertension-associated-with-heart-failure-with-preserved-ejection-fraction
#7
Marc A Simon, Rebecca R Vanderpool, Mehdi Nouraie, Timothy N Bachman, Pamela M White, Masataka Sugahara, John Gorcsan, Ed L Parsley, Mark T Gladwin
BACKGROUND: Pulmonary hypertension (PH) is associated with poor outcomes, yet specific treatments only exist for a small subset of patients. The most common form of PH is that associated with left heart disease (Group 2), for which there is no approved therapy. Nitrite has shown efficacy in preclinical animal models of Group 1 and 2 PH, as well as in patients with left heart failure with preserved ejection fraction (HFpEF). We evaluated the safety and efficacy of a potentially novel inhaled formulation of nitrite in PH-HFpEF patients as compared with Group 1 and 3 PH...
November 3, 2016: JCI Insight
https://www.readbyqxmd.com/read/27810735/profound-differences-between-humans-and-rodents-in-the-ability-to-concentrate-salivary-nitrate-implications-for-translational-research
#8
Marcelo F Montenegro, Michaela L Sundqvist, Carina Nihlén, Michael Hezel, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg
In humans dietary circulating nitrate accumulates rapidly in saliva through active transport in the salivary glands. By this mechanism resulting salivary nitrate concentrations are 10-20 times higher than in plasma. In the oral cavity nitrate is reduced by commensal bacteria to nitrite, which is subsequently swallowed and further metabolized to nitric oxide (NO) and other bioactive nitrogen oxides in blood and tissues. This entero-salivary circulation of nitrate is central in the various NO-like effects observed after ingestion of inorganic nitrate...
October 25, 2016: Redox Biology
https://www.readbyqxmd.com/read/27802417/blood-pressure-lowering-effect-of-orally-ingested-nitrite-is-abolished-by-a-proton-pump-inhibitor
#9
Marcelo F Montenegro, Michaela L Sundqvist, Filip J Larsen, Zhengbing Zhuge, Mattias Carlström, Eddie Weitzberg, Jon O Lundberg
Inorganic nitrate and nitrite from dietary and endogenous sources are metabolized to NO and other bioactive nitrogen oxides that affect blood pressure. The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence the systemic effects of this anion. In a randomized, double-blind, placebo-controlled crossover study, we tested the effects of a proton pump inhibitor on the acute cardiovascular effects of nitrite. Fifteen healthy nonsmoking, normotensive subjects, aged 19 to 39 years, were pretreated with placebo or esomeprazole (3×40 mg) before ingesting sodium nitrite (0...
October 31, 2016: Hypertension
https://www.readbyqxmd.com/read/27799207/sodium-nitrite-inhibits-killing-of-pseudomonas-aeruginosa-biofilms-by-ciprofloxacin
#10
Anna C Zemke, Brian R Kocak, Jennifer M Bomberger
Sodium nitrite inhibits bacterial respiration and is in development as an antimicrobial for chronic bacterial infections associated with Cystic Fibrosis. The goal of the current study was to investigate the interaction between nitrite and ciprofloxacin. Using liquid culture killing assays and a biotic biofilm model, we observed that nitrite induces tolerance to ciprofloxacin.
October 31, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27789769/effect-of-sodium-nitrite-on-local-control-of-contracting-skeletal-muscle-microvascular-oxygen-pressure-in-healthy-rats
#11
Trenton D Colburn, Scott K Ferguson, Clark T Holdsworth, Jesse C Craig, Timothy I Musch, David C Poole
Exercise intolerance characteristic of diseases such as chronic heart failure (CHF) and diabetes is associated with reduced nitric oxide (NO) bioavailability from nitric oxide synthase (NOS), resulting in an impaired microvascular O2 driving pressure (PO2mv; O2 delivery / O2 utilization) and metabolic control. Infusions of the potent NO donor sodium nitroprusside augment NO bioavailability, yet decrease mean arterial pressure (MAP) thereby reducing its potential efficacy for patient populations. To eliminate or reduce hypotensive sequelae, NO2(-) was superfused onto the spinotrapezius muscle...
October 27, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27788621/the-effect-of-ingested-sulfite-on-active-avoidance-in-normal-and-sulfite-oxidase-deficient-aged-rats
#12
Ozlem Ozsoy, Sinem Aras, Ayse Ozkan, Hande Parlak, Burcu Gemici, Nimet Uysal, Mutay Aslan, Piraye Yargicoglu, Aysel Agar
The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring active avoidance learning in normal and sulfite oxidase (SOX)-deficient aged rats. Twenty four months of age Wistar rats were divided into four groups: control (C), sulfite-treated group (S), SOX-deficient group (D) and SOX-deficient + sulfite-treated group (DS). SOX deficiency was established by feeding rats with a low molybdenum (Mo) diet and adding 200 ppm tungsten (W) to their drinking water. Sulfite in the form of sodium metabisulfite (25 mg/kg) was given by gavage for six weeks...
October 28, 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27784948/screening-of-bacillus-strains-from-sun-vinegar-for-efficient-production-of-flavonoid-and-phenol
#13
Changqing Zhao, Xingxiu Zhao, Jing Zhang, Wei Zou, Yi Zhang, Li Li, Jun Liu
The aim of this study was to screen out a bacillus from Sichuan sun vinegar grains capable of producing a high total amount of flavonoids and total phenols. Forty-eight strains were initially screened out from Sichuan sun vinegar grains. The sodium nitrite-aluminum nitrate-sodium hydroxide colorimetry method was used to determine the total flavonoids, and the Folin-phenol method was used to determine the total phenols. Based on the results of total flavonids and total phenol producing capacities of the strains, one strain was singled out for use in this study...
December 2016: Indian Journal of Microbiology
https://www.readbyqxmd.com/read/27779879/multi-scale-modelling-of-the-gamma-radiolysis-of-nitrate-solutions
#14
Gregory Peter Horne, Thomas Ashley Donoclift, Howard Sims, Robin Orr, Simon M Pimblott
A multi-scale modelling approach has been developed for the extended timescale long-term radiolysis of aqueous systems. The approach uses a combination of stochastic track structure and track chemistry as well as deterministic homogeneous chemistry techniques and involves four key stages; radiation track structure simulation, the subsequent physicochemical processes, nonhomogeneous diffusion-reaction kinetic evolution, and homogeneous bulk chemistry modelling. The first three components model the physical and chemical evolution of an isolated radiation chemical track and provide radiolysis yields, within the extremely low dose isolated track paradigm, as the input parameters for a bulk deterministic chemistry model...
October 25, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27769471/au-pt-bimetallic-nanoparticles-supported-on-functionalized-nitrogen-doped-graphene-for-sensitive-detection-of-nitrite
#15
Zhuang Li, Zhenzhen An, Yongyang Guo, Kangning Zhang, Xiaoling Chen, Dongxia Zhang, Zhonghua Xue, Xibin Zhou, Xiaoquan Lu
In this work, we report a novel Au-Pt bimetallic nanoparticles (Au-PtNPs) decorated on the surface of nitrogen-doped graphene (NG) functionalized with 1, 3, 6, 8-pyrene tetra sulfonic acid sodium salt (PyTS) by direct electrodeposition method. The results of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and electrochemical impendence spectrum (EIS) reveal that the Au-PtNPs were successfully anchored on the surface of NG sheets with a diameter of 20-40nm. Further, the prepared Au-PtNPs/PyTS-NG nanocomposite exhibits superior catalytic activity for the oxidation of nitrite...
December 1, 2016: Talanta
https://www.readbyqxmd.com/read/27749634/the-beef-jerky-blues-methemoglobinemia-from-home-cured-meat
#16
Jillian L Theobald, Rachel Spoelhof, Erin M Pallasch, Mark B Mycyk
Methemoglobinemia can result from ingestion of nitrite- or nitrate-containing foods. Here, we report a case where an adolescent girl and her father developed clinically significant methemoglobinemia after ingestion of "homemade" beef jerky prepared with sodium nitrate salt purchased at a local grocery store. Both had palpitations, dyspnea, and visible mucosal cyanosis. The daughter had a methemoglobin level of 44.2% and the father's methemoglobin level was 34.2%. Prompt recognition of methemoglobinemia is important for initiating antidotal therapy with methylene blue...
September 30, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27743016/short-term-treatment-with-nitrate-is-not-sufficient-to-induce-in-vivo-antithrombotic-effects-in-rats-and-mice
#17
K Kramkowski, A Leszczynska, K Przyborowski, B Proniewski, N Marcinczyk, U Rykaczewska, D Jarmoc, E Chabielska, S Chlopicki
In humans, short-term supplementation with nitrate is hypotensive and inhibits platelet aggregation via an nitric oxide (NO)-dependent mechanism. In the present work, we analyzed whether short-term treatment with nitrate induces antithrombotic effects in rats and mice. Arterial thrombosis was evoked electrically in a rat model in which renovascular hypertension was induced by partial ligation of the left renal artery. In mice expressing green fluorescent protein, laser-induced thrombosis was analyzed intravitally by using confocal microscope...
October 14, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27741438/high-radio-frequency-field-strength-nutation-nmr-of-quadrupolar-nuclei
#18
W M J Franssen, Y L A Rezus, A P M Kentgens
Owing to the introduction of microcoils, high RF field strength nutation NMR is a viable candidate for the study of quadrupolar nuclei with strong quadrupolar couplings, not accessible using contemporary NMR techniques. We show powder (23)Na nutation spectra on sodium nitrite for RF field strengths of up to 1170kHz, that conform to theoretical predictions. For lanthanum fluoride powder, (139)La nutation spectra taken at elevated RF field amplitudes show clear discrepancies when compared to the theory. These errors are shown to be mainly caused by pulse transients at the end of the pulse, which proved to be detrimental to the shape of the nutation spectra...
September 28, 2016: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/27741359/the-nitrite-scavenging-properties-of-catechol-resorcinol-and-hydroquinone-a-comparative-study-on-their-nitration-and-nitrosation-reactions
#19
Yunhao Lu, Yanzuo Dong, Xueli Li, Qiang He
The nitration and nitrosation reactions of catechol, resorcinol, and hydroquinone (0.05 mmol/L) with sodium nitrite (0.05 mmol/L) at pH 3 and 37 °C were studied by using liquid chromatography and mass spectrometry (LC-MS) and atom charge analysis, which was aimed to provide chemical insight into the nitrite-scavenging behavior of polyphenols. The 3 benzenediols showed different mechanisms to scavenge nitrite due to their differences in hydroxyl position. Catechol was nitrated with 1 NO2 group at the hydroxyl oxygen, and resorcinol was nitrosated with 2 NO groups at the C2 and C4 (or C6 ) positions of the benzene ring...
October 14, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27738197/hemin-a-heme-oxygenase-1-inducer-restores-the-attenuated-cardioprotective-effect-of-ischemic-preconditioning-in-isolated-diabetic-rat-heart
#20
I Gupta, A Goyal, N K Singh, H N Yadav, P L Sharma
BACKGROUND: Attenuated cardioprotective effect of ischemic preconditioning (IPC) by reduced nitric oxide (NO) is a hallmark during diabetes mellitus (DM). Recently, we reported that the formation of caveolin-endothelial nitric oxide synthase (eNOS) complex decreases the release of NO, which is responsible for attenuation of IPC-induced cardioprotection in DM rat heart. Heme oxygenase-1 (HO-1) facilitates release of NO by disrupting caveolin-eNOS complex. The activity of HO-1 is decreased during DM...
October 12, 2016: Human & Experimental Toxicology
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