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Sodium nitrite

Zhuang Li, Zhenzhen An, Yongyang Guo, Kangning Zhang, Xiaoling Chen, Dongxia Zhang, Zhonghua Xue, Xibin Zhou, Xiaoquan Lu
In this work, we report a novel Au-Pt bimetallic nanoparticles (Au-PtNPs) decorated on the surface of nitrogen-doped graphene (NG) functionalized with 1, 3, 6, 8-pyrene tetra sulfonic acid sodium salt (PyTS) by direct electrodeposition method. The results of scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS) and electrochemical impendence spectrum (EIS) reveal that the Au-PtNPs were successfully anchored on the surface of NG sheets with a diameter of 20-40nm. Further, the prepared Au-PtNPs/PyTS-NG nanocomposite exhibits superior catalytic activity for the oxidation of nitrite...
December 1, 2016: Talanta
Jillian L Theobald, Rachel Spoelhof, Erin M Pallasch, Mark B Mycyk
Methemoglobinemia can result from ingestion of nitrite- or nitrate-containing foods. Here, we report a case where an adolescent girl and her father developed clinically significant methemoglobinemia after ingestion of "homemade" beef jerky prepared with sodium nitrate salt purchased at a local grocery store. Both had palpitations, dyspnea, and visible mucosal cyanosis. The daughter had a methemoglobin level of 44.2% and the father's methemoglobin level was 34.2%. Prompt recognition of methemoglobinemia is important for initiating antidotal therapy with methylene blue...
September 30, 2016: Pediatric Emergency Care
K Kramkowski, A Leszczynska, K Przyborowski, B Proniewski, N Marcinczyk, U Rykaczewska, D Jarmoc, E Chabielska, S Chlopicki
In humans, short-term supplementation with nitrate is hypotensive and inhibits platelet aggregation via an nitric oxide (NO)-dependent mechanism. In the present work, we analyzed whether short-term treatment with nitrate induces antithrombotic effects in rats and mice. Arterial thrombosis was evoked electrically in a rat model in which renovascular hypertension was induced by partial ligation of the left renal artery. In mice expressing green fluorescent protein, laser-induced thrombosis was analyzed intravitally by using confocal microscope...
October 14, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
W M J Franssen, Y L A Rezus, A P M Kentgens
Owing to the introduction of microcoils, high RF field strength nutation NMR is a viable candidate for the study of quadrupolar nuclei with strong quadrupolar couplings, not accessible using contemporary NMR techniques. We show powder (23)Na nutation spectra on sodium nitrite for RF field strengths of up to 1170kHz, that conform to theoretical predictions. For lanthanum fluoride powder, (139)La nutation spectra taken at elevated RF field amplitudes show clear discrepancies when compared to the theory. These errors are shown to be mainly caused by pulse transients at the end of the pulse, which proved to be detrimental to the shape of the nutation spectra...
September 28, 2016: Journal of Magnetic Resonance
Yunhao Lu, Yanzuo Dong, Xueli Li, Qiang He
The nitration and nitrosation reactions of catechol, resorcinol, and hydroquinone (0.05 mmol/L) with sodium nitrite (0.05 mmol/L) at pH 3 and 37 °C were studied by using liquid chromatography and mass spectrometry (LC-MS) and atom charge analysis, which was aimed to provide chemical insight into the nitrite-scavenging behavior of polyphenols. The 3 benzenediols showed different mechanisms to scavenge nitrite due to their differences in hydroxyl position. Catechol was nitrated with 1 NO2 group at the hydroxyl oxygen, and resorcinol was nitrosated with 2 NO groups at the C2 and C4 (or C6 ) positions of the benzene ring...
October 14, 2016: Journal of Food Science
I Gupta, A Goyal, N K Singh, H N Yadav, P L Sharma
BACKGROUND: Attenuated cardioprotective effect of ischemic preconditioning (IPC) by reduced nitric oxide (NO) is a hallmark during diabetes mellitus (DM). Recently, we reported that the formation of caveolin-endothelial nitric oxide synthase (eNOS) complex decreases the release of NO, which is responsible for attenuation of IPC-induced cardioprotection in DM rat heart. Heme oxygenase-1 (HO-1) facilitates release of NO by disrupting caveolin-eNOS complex. The activity of HO-1 is decreased during DM...
October 12, 2016: Human & Experimental Toxicology
Rajendran Senthil Kumar, Chin-Hui Shen, Pei-Yin Wu, Subbiah Suresh Kumar, Moda Sang Hua, Kai-Wun Yeh
In Oncidium, redox homeostasis involved in flowering is mainly due to ascorbic acid (AsA). Here, we discovered that Oncidium floral repression is caused by an increase in AsA-mediated NO levels, which is directed by the enzymatic activities of nitrate reductase (NaR) and nitrite reducatase (NiR). Through Solexa transcriptomic analysis of two libraries, 'pseudobulb with inflorescent bud' (PIB) and 'pseudobulb with axillary bud' (PAB), we identified differentially expressed genes related to NO metabolism. Subsequently, we showed a significant reduction of NaR enzymatic activities and NO levels during bolting and blooming stage, suggesting that NO controlled the phase transition and flowering process...
October 12, 2016: Scientific Reports
Daniel A Jones, Rayomand S Khambata, Mervyn Andiapen, Krishnaraj S Rathod, Anthony Mathur, Amrita Ahluwalia
OBJECTIVE: Recent work suggests that intracoronary nitrite reduces myocardial infarct size following primary percutaneous coronary intervention (PPCI) for acute myocardial infarction (AMI), although the exact mechanisms are unclear. We explored the effects of nitrite on reperfusion-induced inflammation, by assessing the levels of specific pro-inflammatory mediators, chemokines and adhesion molecules in plasma and circulating cell subtypes as exploratory end points in the NITRITE-AMI cohort...
September 28, 2016: Heart: Official Journal of the British Cardiac Society
Fariheen Aisha Ansari, Shaikh Nisar Ali, Riaz Mahmood
Sodium nitrite (NaNO2 ) is a common contaminant of drinking water and food and feed chain. Nitrite induces oxidative damage in humans and animals. In this work we studied the protective effect of crocin, the active constituent of Crocus sativus (saffron), on NaNO2 -induced oxidative damage in human erythrocytes. Changes in oxidative stress parameters following NaNO2 incubation of erythrocytes in presence and absence of crocin were determined. It was found that crocin pre-treatment significantly attenuated NaNO2 -induced oxidative damage of proteins, lipids and plasma membrane...
September 28, 2016: Cell Biology International
Na-Kyoung Lee, Hyun-Dong Paik
This review discusses the status, antimicrobial mechanisms, application, and regulation of natural preservatives in livestock food systems. Conventional preservatives are synthetic chemical substances including nitrates/nitrites, sulfites, sodium benzoate, propyl gallate, and potassium sorbate. The use of artificial preservatives is being reconsidered because of concerns relating to headache, allergies, and cancer. As the demand for biopreservation in food systems has increased, new natural antimicrobial compounds of various origins are being developed, including plant-derived products (polyphenolics, essential oils, plant antimicrobial peptides (pAMPs)), animal-derived products (lysozymes, lactoperoxidase, lactoferrin, ovotransferrin, antimicrobial peptide (AMP), chitosan and others), and microbial metabolites (nisin, natamycin, pullulan, ε-polylysine, organic acid, and others)...
2016: Korean Journal for Food Science of Animal Resources
Hyun-Joo Kim, Nak-Yun Sung, Hae In Yong, Hanwool Kim, Younggap Lim, Kwang Hyun Ko, Cheol-Heui Yun, Cheorun Jo
Cold plasma has been developed to reduce microbial contamination and to improve safety of food and medical products. In addition, the technology can be used in the manufacture of sausages without addition of nitrite. To be applied in food industry commercially, the new technology should be safe and efficient. However, toxicological test of plasma-treated food is limited. Therefore, the purpose of this study was to determine the mutagenicity and immune toxicity of the meat products cured with plasma-treated water (PTW) as a nitrite source...
2016: Korean Journal for Food Science of Animal Resources
Jean Nyakayiru, Kristin L Jonvik, Philippe J M Pinckaers, Joan Senden, Luc J C Van Loon, Lex B Verdijk
While the majority of studies reporting ergogenic effects of dietary nitrate have used a multiday supplementation protocol, some studies suggest that a single dose of dietary nitrate prior to exercise can also improve subsequent performance. We aimed to compare the impact of acute and 6-day sodium nitrate supplementation on oxygen uptake (V̇O2) and time-trial performance in trained cyclists. Using a randomized, double blind, cross-over design, 17 male cyclists (25±4 y, V̇O2peak 65±4 mL·kg(-1)·min(-1), Wmax 411±35 W) were subjected to 3 different trials; 5 days placebo and 1 day sodium nitrate supplementation (1-DAY); 6 days sodium nitrate supplementation (6-DAY); 6 days placebo supplementation (PLA)...
September 6, 2016: International Journal of Sport Nutrition and Exercise Metabolism
Wei Chih Ling, Dharmani Devi Murugan, Yeh Siang Lau, Paul M Vanhoutte, Mohd Rais Mustafa
Sodium nitrite (NaNO2) induces relaxation in isolated arteries partly through an endothelium-dependent mechanism involving NO-eNOS-sGC-cGMP pathway. The present study was designed to investigate the effect of chronic NaNO2 administration on arterial systolic blood pressure (SBP) and vascular function in hypertensive rats. NaNO2 (150 mg L-1) was given in drinking water for four weeks to spontaneously (SHR) and Nω-Nitro-L-arginine methyl ester hydrochloride (L-NAME) treated hypertensive SD rats. Arterial SBP and vascular function in isolated aortae were studied...
2016: Scientific Reports
Dimitrios Tsikas, Mario Schmidt, Erik Hanff, Anke Böhmer
A GC-MS method is reported for the quantitative analysis of S-nitrosothiols (RSNO) derived from endogenous low- and high-molecular mass thiols (RSH) including hemoglobin, cysteine, glutathione, N-acetylcysteine, and the exogenous N-acetylcysteine ethyl ester. The method is based on the conversion of RSNO to nitrite by aqueous Na2S (S(2-)). (15)N-Labelled analogs (RS(15)NO) or (15)N-labelled nitrite and nitrate were used as internal standards. The nitrite ((14)NO2(-) and (15)NO2(-)) and nitrate (O(14)NO2(-) and O(15)NO2(-) anions were derivatised by pentafluorobenzyl (PFB) bromide (PFB-Br) in aqueous acetone and their PFB derivatives were separated by gas chromatography...
September 3, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Bárbara S Rocha, Mariana G Correia, Rita C Fernandes, João S Gonçalves, João Laranjinha
The clinical implications of the nitrate-nitrite-nitric oxide pathway have been extensively studied in recent years. However, the physiological impact of bioactive nitrogen oxides produced from dietary nitrate has remained largely elusive. Here, we report a hitherto unrecognized nitrite-dependent nitrating pathway that targets tight junction proteins in the stomach. Inorganic nitrate, nitrite or saliva obtained after the consumption of lettuce were administered by oral gavage to Wistar rats. The enterosalivary circulation of nitrate was allowed to occur for 4 h after which the animals were euthanized and the stomach collected...
October 11, 2016: Free Radical Research
Simone Porcelli, Lorenzo Pugliese, Enrico Rejc, Gaspare Pavei, Matteo Bonato, Michela Montorsi, Antonio La Torre, Letizia Rasica, Mauro Marzorati
It has been reported that nitrate supplementation can improve exercise performance. Most of the studies have used either beetroot juice or sodium nitrate as a supplement; there is lack of data on the potential ergogenic benefits of an increased dietary nitrate intake from a diet based on fruits and vegetables. Our aim was to assess whether a high-nitrate diet increases nitric oxide bioavailability and to evaluate the effects of this nutritional intervention on exercise performance. Seven healthy male subjects participated in a randomized cross-over study...
2016: Nutrients
Zhiyi Sun, Yongkang Lv, Yuxiang Liu, Ruipeng Ren
A novel heterotrophic nitrifying and metal resistant bacterium was isolated and identified as Cupriavidus sp. S1. The utilization of ammonium, nitrate and nitrite as well as the production of N2 proved the heterotrophic nitrification and aerobic denitrification ability of S1. The ammonium, nitrate and nitrite removal efficiencies were 99.68%, 98.03% and 99.81%, with removal rates of 10.43, 8.64 and 8.36mg/L/h, respectively. A multiple regression equation well described the relationship between carbon source utilization, cell growth and nitrification...
November 2016: Bioresource Technology
Kenichi Katabami, Mineji Hayakawa, Satoshi Gando
Case. We report a case of severe methemoglobinemia due to sodium nitrite poisoning. A 28-year-old man was brought to our emergency department because of transient loss of consciousness and cyanosis. He was immediately intubated and ventilated with 100% oxygen. A blood test revealed a methemoglobin level of 92.5%. Outcome. We treated the patient with gastric lavage, activated charcoal, and methylene blue (2 mg/kg) administered intravenously. Soon after receiving methylene blue, his cyanosis resolved and the methemoglobin level began to decrease...
2016: Case Reports in Emergency Medicine
Ling-Yu Guo, Su-Yuan Zeng, Zvonko Jagličić, Qi-Dong Hu, Shi-Xuan Wang, Zhi Wang, Di Sun
A planar hexanuclear cobalt ring was clamped by two bivacant α1-[PW10O37](9-) with the assistance of the pyridazine bridges to form a novel sandwiched Co(II)-polyoxometalate cluster compound, [Na(H2O)6][Co3(OH) (pydz)4(H2O)7][Co6(PW10O37)2(pydz)4(H2O)6]·43H2O (1; pydz = pyridazine).This cluster was identified by X-ray single-crystal diffraction, elemental analysis, Fourier transform IR and UV-visible spectroscopies, and cyclic voltammetry (CV). Structural analysis reveals that 1 comprises a hexahydrated sodium, a trinuclear [Co3(OH) (pydz)4(H2O)7](5+) cationic cluster, and an anionic [Co6(PW10O37)2(pydz)4(H2O)6](6-) sandwiched cluster, thus giving an intrinsical intercluster compound...
September 6, 2016: Inorganic Chemistry
Christina Böhnlein, Jan Kabisch, Diana Meske, Charles M A P Franz, Rohtraud Pichner
: In 2011, one of the world's largest outbreaks of hemolytic-uremic syndrome (HUS) occurred, caused by a rare Escherichia coli serotype, O104:H4, that shared the virulence profiles of Shiga toxin-producing E. coli (STEC)/enterohemorrhagic E. coli (EHEC) and enteroaggregative E. coli (EAEC). The persistence and fitness factors of the highly virulent EHEC/EAEC O104:H4 strain, grown either in food or in vitro, were compared with those of E. coli O157 outbreak-associated strains. The log reduction rates of the different EHEC strains during the maturation of fermented sausages were not significantly different...
November 1, 2016: Applied and Environmental Microbiology
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