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Sodium nitrite

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https://www.readbyqxmd.com/read/29674754/preparation-of-a-nile-red-pd-based-fluorescent-co-probe-and-its-imaging-applications-in-vitro-and-in-vivo
#1
Keyin Liu, Xiuqi Kong, Yanyan Ma, Weiying Lin
Carbon monoxide (CO) is a key gaseous signaling molecule in living cells and organisms. This protocol illustrates the synthesis of a highly sensitive Nile Red (NR)-Pd-based fluorescent probe, NR-PdA, and its applications for detecting endogenous CO in tissue culture cells, ex vivo organs, and zebrafish embryos. In the NR-PdA synthesis process, 3-diethylamine phenol reacts with sodium nitrite in the acidic condition to afford 5-(diethylamino)-2-nitrosophenol hydrochloride (compound 1), which is further treated with 1-naphthalenol at a high temperature to provide the NR dye via a cyclization reaction...
May 2018: Nature Protocols
https://www.readbyqxmd.com/read/29660141/carbonic-anhydrase-is-not-a-relevant-nitrite-reductase-or-nitrous-anhydrase-in-the-lung
#2
Philipp A Pickerodt, Sebastian Kronfeldt, Martin Russ, Adrian Gonzalez-Lopez, Philipp Lother, Elvira Steiner, Katja Vorbrodt, Thilo Busch, Willehad Boemke, Roland C E Francis, Erik R Swenson
The carbonic anhydrase (CA) inhibitors, acetazolamide and its structurally similar analogue, methazolamide prevent or reduce hypoxic pulmonary vasoconstriction (HPV) in dogs and humans in vivo, by a mechanism unrelated to CA inhibition. In rodent blood and isolated blood vessels, Aamand et al. (2009) reported that inhibition of CA led to increased generation of nitric oxide (NO) from nitrite and vascular relaxation in vitro. We tested the physiological relevance of augmented NO generation by CA from nitrite with acetazolamide in anaesthetized pigs during alveolar hypoxia in vivo...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29659727/nitrite-circumvents-platelet-resistance-to-nitric-oxide-in-patients-with-heart-failure-preserved-ejection-fraction-and-chronic-atrial-fibrillation
#3
Alessandra Borgognone, Eduard Shantsila, Sophie M Worrall, Eakkapote Prompunt, Thomas Loka, Brodie L Loudon, Myriam Chimen, G Ed Rainger, Janet M Lord, Ashley Turner, Peter Nightingale, Martin Feelisch, Paulus Kirchhof, Gregory Y H Lip, Steve P Watson, Michael P Frenneaux, Melanie Madhani
Aims: Heart failure (HF) is a pro-thrombotic state. Both platelet and vascular responses to nitric oxide (NO) donors are impaired in HF patients with reduced ejection fraction (HFrEF) compared to healthy volunteers (HV) due to scavenging of NO, and possibly also reduced activity of the principal NO sensor, soluble guanylate cyclase (sGC), limiting the therapeutic potential of NO donors as anti-aggregatory agents. Previous studies have shown that nitrite inhibits platelet activation presumptively after its reduction to NO, but the mechanism(s) involved remain poorly characterized...
April 12, 2018: Cardiovascular Research
https://www.readbyqxmd.com/read/29657939/cisplatin-alters-sodium-excretion-and-renal-clearance-in-rats-gender-and-drug-dose-related
#4
Sima Jilanchi, Ardeshir Talebi, Mehdi Nematbakhsh
Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29655557/an-evaluation-of-the-effectiveness-of-a-chemical-additive-based-on-sodium-benzoate-potassium-sorbate-and-sodium-nitrite-on-the-fermentation-and-aerobic-stability-of-corn-silage
#5
Limin Kung, Megan L Smith, Erica Benjamim da Silva, Michelle C Windle, Thiago C da Silva, Stephanie A Polukis
We evaluated the effectiveness of an additive comprising sodium benzoate, potassium sorbate, and sodium nitrite (SSL) as active ingredients for its ability to improve the aerobic stability of corn silages made in North America. In experiment 1, treatment with SSL (1.5 and 2.0 L/t) on whole-plant corn (WPC) was compared with treatment with an additive containing buffered propionic acid and citric acid (BPA; 2 L/t) on corn harvested at 32 and 38% DM and ensiled for 120 d. Silage treated with BPA was higher in ammonia-N and propionic acid relative to other treatments...
April 11, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29643809/examination-of-the-role-of-mitochondrial-morphology-and-function-in-the-cardioprotective-effect-of-sodium-nitrite-administered-24-h-before-ischemia-reperfusion-injury
#6
Vivien Demeter-Haludka, Mária Kovács, Alexandra Petrus, Roland Patai, Danina M Muntean, László Siklós, Ágnes Végh
Background: We have previous evidence that in anesthetized dogs the inorganic sodium nitrite protects against the severe ventricular arrhythmias, resulting from coronary artery occlusion and reperfusion, when administered 24 h before. The present study aimed to examine, whether in this effect changes in mitochondrial morphology and function would play a role. Methods: Thirty dogs were infused intravenously either with saline ( n = 15) or sodium nitrite (0.2 μmol/kg/min; n = 15) for 20 min, and 24 h later, 10 dogs from each group were subjected to a 25 min period of occlusion and then reperfusion of the left anterior descending coronary artery...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29628462/-long-term-dietary-nitrite-and-nitrate-deficiency-causes-metabolic-syndrome-endothelial-dysfunction-and-cardiovascular-death-in-mice
#7
Mika Kina-Tanada, Mayuko Sakanashi, Akira Arasaki, Masato Tsutsui
Nitric oxide (NO) is synthesized not only from L-arginine by NO synthases (NOSs), but also from its inert metabolites, nitrite and nitrate. Green leafy vegetables are abundant in nitrate, however whether or not a deficiency in dietary nitrite/nitrate spontaneously causes disease remains to be clarified. In this study, we tested our hypothesis that long-term dietary nitrite/nitrate deficiency induces metabolic syndrome (MetS) in mice. To this end, we prepared a low nitrite/nitrate diet (LND) consisting of an amino acid-based low nitrite/nitrate chow in which the contents of L-arginine, fat, carbohydrates, protein, and energy were identical with a regular chow, and potable ultrapure water...
2018: Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
https://www.readbyqxmd.com/read/29624855/evaluation-of-movement-behaviors-to-inform-toxic-baiting-strategies-for-invasive-wild-pigs-sus-scrofa
#8
Michael J Lavelle, Nathan P Snow, Joseph M Halseth, Eric H VanNatta, Heather N Sanders, Kurt C VerCauteren
BACKGROUND: Invasive wild pigs damage agriculture, property, and natural ecosystems. To curtail damage, an effective and humane toxic bait containing microencapsulated sodium nitrite is under development. Strategies for delivering the toxic bait are needed to establish adequate spacing of bait sites, and for simultaneously accustoming wild pigs to the novel bait and wild pig-specific bait stations designed to exclude non-target species. RESULTS: We monitored movements of 32 GPS collared wild pigs relative to 41 bait sites containing placebo bait...
April 6, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29618429/assessing-the-efficacy-of-aqueous-garlic-extract-sodium-nitrite-and-sodium-thiosulfate-against-prolonged-oral-cyanide-exposure-in-rabbits
#9
Muhammad Avais, Muhammad Sarwar Khan, Muhammad Arif Khan, Kamran Ashraf, Zahoorul Hassan, Jawaria Ali Khan, Nisar Ahmad
This study was aimed to compare the efficacy of aqueous garlic extract, sodium nitrite (SNT), sodium thiosulfate (STS) and hydroxocobalamin against oral cyanide exposure in rabbits. For this purpose, forty two adult male rabbits were divided randomly into 7 groups of 6 animals (A-G) each. Rabbits in group A were offered feed only and served as negative control, while the rabbits in group B received feed plus potassium cyanide (KCN) at 3mg/kg orally and were kept as positive control. Animals in group C received feed, KCN and intraperitoneal injection (IP) of aqueous garlic extract at 500mg/kg...
March 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29604187/investigating-the-possible-mechanisms-involved-in-adenosine-preconditioning-induced-cardioprotection-in-rats
#10
Lovedeep Singh, Jasleen Kaur Virdi, L N Maslov, Nirmal Singh, Amteshwar Singh Jaggi
BACKGROUND: Adenosine is a breakdown product of adenosine triphosphate and plays an important role in pharmacological preconditioning. The cardioprotective effects of adenosine preconditioning are well established. However, the possible mechanisms need to be explored. AIM: The present study was aimed to investigate the possible mechanisms involved in adenosine preconditioning-induced cardioprotection in rats. METHODS: Rat heart was isolated and perfused on Langendorff apparatus...
March 31, 2018: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/29565948/a-randomized-double-blind-study-of-the-effects-of-a-sustained-release-formulation-of-sodium-nitrite-sr-nitrite-on-patients-with-diabetic-neuropathy
#11
Amol Soin, Glen Bock, Anthony Giordano, Chirag Patel, David Drachman
BACKGROUND: Sodium nitrite has been reported to be effective in reducing chronic peripheral pain. OBJECTIVES: To evaluate the safety and efficacy of 40 and 80 mg, BID, of an oral sustained release formulation of sodium nitrite (SR-nitrite) in patients suffering from diabetic neuropathy, and to determine whether SR-nitrite would reduce the frequency of headaches reported previously by subjects receiving the same doses of an immediate release formulation. STUDY DESIGN: Phase II, single-center, randomized, double-blind, placebo controlled clinical trial...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29565678/chronic-intermittent-hypobaric-hypoxia-4600-m-attenuates-pulmonary-vasodilation-induced-by-acetylcholine-or-sodium-nitroprusside
#12
Fernando A Moraga, Giselle Miranda, Vasthi López, Carmen Vallejos, Daniel Silva
Moraga, Fernando A., Giselle Miranda, Vasthi López, Carmen Vallejos, and Daniel Silva. Chronic intermittent hypobaric hypoxia (4600 M) attenuates pulmonary vasodilation induced by acetylcholine or sodium nitroprusside. High Alt Med Biol. 00: 000-000, 2018. BACKGROUND: Previous studies performed in rats exposed to chronic intermittent hypobaric hypoxia (CIHH), at a simulated altitude of 4600 m, showed reduced nitric oxide (NO) production, increased arginase activity, and increased oxidative stress...
March 22, 2018: High Altitude Medicine & Biology
https://www.readbyqxmd.com/read/29551571/the-investigation-of-the-use-of-beetroot-powder-in-turkish-fermented-beef-sausage-sucuk-as-nitrite-alternative
#13
Cisem Sucu, Gulen Yildiz Turp
The objective of this study was to examine the effects of reformulation of Turkish dry fermented beef sausage (sucuk) by replacing nitrite with beetroot powder (BP), which has high nitrate content, on some quality characteristics of the product during storage at 4 °C for 84 days. Four different sausage formulations were produced containing C:150 mg/kg sodium nitrite; BS1:100 mg/kg sodium nitrite and 0.12% BP; BS2:50 mg/kg sodium nitrite and 0.24% BP and BS3: 0.35% BP. The inclusion of BP increased a* value of samples and resulted in the protection of the desired red color during storage...
March 15, 2018: Meat Science
https://www.readbyqxmd.com/read/29533524/prebiotic-methylations-and-carbamoylations-generate-non-canonical-rna-nucleosides-as-molecular-fossils-of-an-early-earth
#14
Christina Schneider, Sidney Becker, Hidenori Okamura, Antony Crisp, Tynchtyk Amatov, Michael Stadlmeier, Thomas Carell
The RNA world hypothesis assumes that life on earth started with small RNA molecules that catalyzed their own formation. Vital to this hypothesis is the need for prebiotic routes towards RNA. Contemporary RNA, however, is not only constructed from the four canonical nucleobases (A, C, G and U), but it contains in addition many chemically modified (non-canonical) bases. A yet open question is if these non-canonical bases were formed in parallel to the canonical bases (chemical origin), or whether they were created later, when life demanded higher functional diversity (biological origin)...
March 13, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29526907/partition-ion-exclusion-chromatographic-ion-stacking-for-the-analysis-of-trace-anions-in-water-and-salt-samples-by-ion-chromatography
#15
Fouzia Akter, Shingo Saito, Yuiko Tasaki-Handa, Masami Shibukawa
A new analytical methodology for a simple and efficient on-line preconcentration of trace inorganic anions in water and salt samples prior to ion chromatographic determination is proposed. The preconcentration method is based on partition/ion-exclusion chromatographic ion stacking (PIEC ion stacking) with a hydrophilic polymer gel column containing a small amount of fixed anionic charges. The developed on-line PIEC ion stacking-ion chromatography method was validated by recovery experiments for the determination of nitrate in tap water in terms of both accuracy and precision, and the results showed the reliability of the method...
2018: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/29522355/eight-weeks-of-nitrate-supplementation-improves-blood-flow-and-reduces-the-exaggerated-pressor-response-during-forearm-exercise-in-peripheral-arterial-disease
#16
Nicholas T Kruse, Kenichi Ueda, William E Hughes, Darren P Casey
Peripheral arterial disease (PAD) is characterized by a reduced blood flow (BF) and elevated blood pressure (pressor) response during lower extremity exercise. Although PAD is evident in the upper extremities no studies have determined BF and pressor responses during upper extremity exercise in PAD. Emerging evidence suggests that inorganic nitrate (NO3 ) supplementation may serve as an alternative dietary strategy to boost nitric oxide bioavailability, improving exercising BF and pressor responses during exercise...
March 9, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29513738/accuracy-of-detection-of-carboxyhemoglobin-and-methemoglobin-in-human-and-bovine-blood-with-an-inexpensive-pocket-size-infrared-scanner
#17
Margot P Bickler, Laura J Rhodes
Detecting life-threatening common dyshemoglobins such as carboxyhemoglobin (COHb, resulting from carbon monoxide poisoning) or methemoglobin (MetHb, caused by exposure to nitrates) typically requires a laboratory CO-oximeter. Because of cost, these spectrophotometer-based instrument are often inaccessible in resource-poor settings. The aim of this study was to determine if an inexpensive pocket infrared spectrometer and smartphone (SCiO®Pocket Molecular Sensor, Consumer Physics Ltd., Israel) accurately detects COHb and MetHb in single drops of blood...
2018: PloS One
https://www.readbyqxmd.com/read/29505257/bioregeneration-of-chabazite-during-nitrification-of-centrate-from-anaerobically-digested-livestock-waste-experimental-and-modeling-studies
#18
Veronica E Aponte-Morales, Karl A Payne, Jeffrey A Cunningham, Sarina J Ergas
Nitrification of high total ammonia nitrogen-strength wastewaters is challenging due to free ammonia (FA) inhibition of nitrification. FA inhibition can potentially be alleviated by temporarily adsorbing ammonium (NH4+) to natural zeolite, such as chabazite, followed by direct zeolite bioregeneration via nitrification. In this research, the effectiveness of chabazite addition for reducing nitrification inhibition during treatment of centrate from anaerobic digestion of swine waste was quantified. A mathematical model was developed that accounts for ion exchange of NH4+ and sodium at the chabazite surface, surface diffusion of adsorbed NH4+ within the chabazite grains, sequential nitrification of aqueous NH4+ to nitrite and nitrate, and inhibition of nitritation and nitratation rates by NH4+...
March 5, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29500923/regulation-of-hypoxia-inducible-factor-prolyl-hydroxylase-binding-domain-proteins-1-by-ppar%C3%AE-and-high-salt-diet
#19
Ezinne Ozurumba, Omana Mathew, Katsuri Ranganna, Myung Choi, Adebayo Oyekan
BACKGROUND: Hypoxia inducible factor (HIF)/prolyl hydroxylase domain (PHD)-containing proteins are involved in renal adaptive response to high salt (HS). Peroxisome proliferator activated receptor alpha (PPARα), a transcription factor involved in fatty acid oxidation is implicated in the regulation of renal function. As both HIF-1α/PHD and PPARα contribute to the adaptive changes to altered oxygen tension, this study tested the hypothesis that PHD-induced renal adaptive response to HS is PPARα-dependent...
March 28, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29473797/formation-and-inhibition-of-n-nitrosodiethanolamine-in-cosmetics-under-ph-temperature-and-fluorescent-ultraviolet-and-visual-light
#20
Duck Soo Lim, Seung Kwang Lim, Min Kook Kim, Yong Chan Kwon, Tae Hyun Roh, Seul Min Choi, Sungpil Yoon, Hyung Sik Kim, Byung-Mu Lee
N-nitrosodiethanolamine (NDELA), a type of nitrosamine, is a possible human carcinogen that may form in cosmetic products. The aim of this study was to examine the formation and inhibition of NDELA through chemical reactions of secondary amines including mono-ethanolamine, di-ethanolamine (DEA), and tri-ethanolamine (TEA), and sodium nitrite (SN) under varying conditions such as pH, temperature, and fluorescent, ultraviolet (UV), and visual light (VIS) using liquid chromatography-mass spectroscopy. In a mixture of TEA and SN under acidic conditions pH 2, residual NDELA concentrations rose significantly under various storage conditions in the following order: 50°C > 40°C > UV (2 W/m2 ) > VIS (4000 lux) > fluorescent light > 25°C > 10°C...
February 23, 2018: Journal of Toxicology and Environmental Health. Part A
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