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Sodium nitrite

Tarlan Varzandi, Mahammad Amin Abdollahifar, Seyed Ali Haeri Rohani, Abbas Piryaei, Azita Zadeh-Vakili, Sajad Jeddi, Asghar Ghasemi
INTRODUCTION: Nitric oxide (NO) deficiency is associated with obesity and type 2 diabetes. Nitrite, a NO donor, is considered as a new therapeutic agent in diabetes. This study aims at determining effects of long-term nitrite administration on browning of white adipose tissue (WAT) in type 2 diabetic rats. METHODS: Male rats were divided into 4 groups: Control, control + nitrite, diabetes, and diabetes + nitrite. Sodium nitrite (50 mg/L in drinking water) was administered for 3 months...
June 10, 2018: Life Sciences
Daniel A Jones, Krishnaraj S Rathod, Anna Williamson, Deirdre Harrington, Mervyn Andiapen, Sven van Eijl, Mark Westwood, Sotiris Antoniou, Richard J Schilling, Amrita Ahluwalia, Anthony Mathur
OBJECTIVE: Pre-clinical evidence suggests delivery of nitric oxide (NO) through administration of inorganic nitrite suppresses arrhythmias resulting from acute ischaemia and reperfusion (I/R). To date no assessment of whether inorganic nitrite might limit reperfusion arrhythmia has occurred in man, therefore we explored the effects on I/R-induced ventricular arrhythmias in the NITRITE-AMI cohort. METHODS: In the NITRITE-AMI cohort, Holter analysis was performed prior to and for 24 h after primary PCI in 80 patients who received either intra-coronary sodium nitrite (N = 40) or placebo (N = 40) during primary PCI for AMI...
September 1, 2018: International Journal of Cardiology
Laila Mohamed Fadda, Hala A Attia, Nouf Mohamed Al-Rasheed, Hanaa Mahmoud Ali, Nawal Mohamed Al-Rasheed
This study assessed the effect of L-arginine (L-argin), carnosine (carno), or their combination in the amelioration of certain biochemical indices induced in the liver of hypoxic rats. Hypoxia was induced via sodium nitrite (S.nit) injection at a dose of 75 mg/kg. Rats were administered L-argin (250 mg/kg) or carno (250 mg/kg), either alone or in combination, 24 hours and 1 hour prior to S.nit intoxication. Hypoxia significantly elevated serum alanine aminotransferase, in addition to a significant upregulation of hepatic heat shock protein 70 with concurrent reduction in the level of vascular endothelial growth factor...
April 2018: Dose-response: a Publication of International Hormesis Society
Suraj Ghosh, Rumi Rabha, Mallika Chowdhury, Pratap Kumar Padhy
Levels of particulate matter of size ten micron (PM10 ) in outdoor air, potential PM10 -bound seven metals - manganese, zinc, cadmium, lead, copper, nickel and cobalt - and twelve water-soluble organic and inorganic ionic components - fluoride, acetate, chloride, nitrite, bromide, nitrate, phosphate, sulfate, oxalate, sodium, potassium and calcium - were investigated during two different season. Atmospheric PM10 samples were collected concurrently from three different sites, i.e., Durgapur (Industrial), Berhampore (Urban) and Bolpur (Semi-urban), West Bengal, India, during summer (April-June 2014) and winter (December 2014-February 2015)...
May 23, 2018: Chemosphere
Paulo César de Paula Vasconcelos, Cleide Adriani Signor Tirloni, Rhanany Alan Calloi Palozi, Maicon Matos Leitão, Maria Tainara Soares Carneiro, Maysa Isernhagen Schaedler, Aniely Oliveira Silva, Roosevelt Isaias Carvalho Souza, Marcos José Salvador, Arquimedes Gasparotto Junior, Cândida Aparecida Leite Kassuya
ETHNOPHARMACOLOGICAL RELEVANCE: Gomphrena celosioides Mart., belonging to the Amaranthaceae family, is a weed known as "perpétua," and its ethnopharmacological use is to treat of urinary tract disorders and kidney stones. Urinary tract disorders and kidney stones could include several pathological conditions such hypertension, diuretic and lithiasic problems. In the present work a model of renovascular hypertension was developed in vivo to investigate its usefulness as an antihypertensive drug...
May 26, 2018: Journal of Ethnopharmacology
Meei Chien Quek, Nyuk Ling Chin, Yus Aniza Yusof, Chung Lim Law, Sheau Wei Tan
Edible bird's nest (EBN) is a precious food made from the solidified saliva of swiftlets. EBN from three types of origin, namely production, swiftlet species and geographical were characterised based on its nutritional composition, physicochemical properties and antioxidant properties. Proximate composition, total phenolic content (TPC) and antioxidant activities were determined following official methods, while mineral and heavy metal contents were obtained by respective atomic adsorption spectrometry (AAS) and inductively coupled plasma-mass spectrometry (ICP-MS)...
July 2018: Food Research International
M Capelari, K A Johnson, B Latack, J Roth, W Powers
Because enteric methane (CH4) production from ruminants represents a source of greenhouse gas emissions and an energy loss for the host animal alternatives to minimize emissions is a current research priority. Seven 37-d trials tested the effect of encapsulated nitrate (EN) and sodium monensin (MON) in diets commonly fed to dairy (DAIRY; 50:50 forage to concentrate; 4 trials) and beef cattle (BEEF; 15:85 forage to concentrate; 3 trials) on rumen fermentation and CH4 production using a semi-continuous fermentation system...
May 25, 2018: Journal of Animal Science
Marcin Wieczorek, Marek Dębosz, Paweł Świt, Aneta Woźniakiewicz, Paweł Kościelniak
A new gradient ratio approach to Chemical H-point Standard Addition Method (C-HPSAM) was developed in flow injection analysis with spectrophotometric detection. C-HPSAM is based on an idea to use SAM for calibration in several different chemical conditions in order to correct unspecific (additive) interferences in samples with unknown matrix. The approach proposed in this paper employs the gradient ratio flow-injection technique to generate a continuous change of chemical conditions. By doing so a set of two-point SAM calibration curves with different slopes are possible of registering that are intersected in a common point indicating the values of both unspecific interferences and analyte concentration in a sample...
August 15, 2018: Talanta
Inderpreet Kaur, Sonal Gaba, Sukhraj Kaur, Rajeev Kumar, Jyoti Chawla
A spectrophotometric method based on diazotization of aniline with triclosan has been developed for the determination of triclosan in water samples. The diazotization process involves two steps: (1) reaction of aniline with sodium nitrite in an acidic medium to form diazonium ion and (2) reaction of diazonium ion with triclosan to form a yellowish-orange azo compound in an alkaline medium. The resulting yellowish-orange product has a maximum absorption at 352 nm which allows the determination of triclosan in aqueous solution in the linear concentration range of 0...
May 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Bianca Olivieri, Mark Marić, Candice Bridge
The use of immunoassays for drug screening has increased due to their sensitivity towards target analytes, specifically the enzyme linked immunosorbent assay (ELISA) technique. Adulterant test strips are commonly used in conjunction with immunoassay tests to ensure that the integrity of the specimen has not been altered prior to drug screening. This research focuses on determining which adulterants can produce a false negative result, not only with one of the screening tests, but throughout the entire screening process...
May 10, 2018: Drug Testing and Analysis
Fariheen Aisha Ansari, Aijaz Ahmed Khan, Riaz Mahmood
The widespread use of sodium nitrite (NaNO2 ) as food preservative, rampant use of nitrogenous fertilizers for agricultural practices, and improper disposal of nitrogenous wastes have drastically increased human exposure to high nitrite levels causing various health disorders and death. In the present study, the protective effect of carnosine and N-acetylcysteine (NAC) against NaNO2 -induced intestinal toxicity in rats was investigated. Animals were given a single acute oral dose of NaNO2 at 60 mg/kg body weight with or without prior administration of either carnosine at 100 mg/kg body weight/day for 7 days or NAC at 100 mg/kg body weight/day for 5 days...
May 4, 2018: Environmental Science and Pollution Research International
Ayad M R Raauf, Rafah F Al-Smaism, Khalida A Thejeel, Hala Ayad M Rasheed
New compounds of trimethoprim heterocyclic derivatives were synthesized. These compounds were synthesized through the condensation reaction between trimethoprim with bromoacetic acid to yield compound 1. Several Schiff bases 2-7 have been synthesized by the condensation different aromatic aldehydes with compound 1. Compound 8 were formed from the reaction of sodium nitrite and acetyl acetone in presence of conc. hydrogen chloride to obtain the hydrazono derivative; then, Cyclocondensation of compound 8 with hydrazine hydrate, phenyl hydrazine and dinitrophenyl hydrazine respectively to yield compounds 9-11 in ethanol affording the pyrazoline derivatives...
May 4, 2018: Natural Product Research
Masashi Tawa, Takahide Furukawa, Hiroko Tongu, Mai Sugihara, Satoko Taguwa, Misaki Yamanaka, Yoko Yano, Hiroaki Matsumori, Rie Kitada, Tatsuya Sawano, Ryosuke Tanaka, Mamoru Ohkita, Yasuo Matsumura
AIMS: In this study, we examined whether a disruption in the balance between nitric oxide (NO)-sensitive and -insensitive soluble guanylate cyclase (sGC) is observed in pulmonary hypertension (PH) and whether treatment with NO-enhancing drugs can halt disease progression. MAIN METHODS: Rats were injected subcutaneously with saline or 60 mg/kg monocrotaline (MCT). At 14 days after injection, the vascular reactivity of isolated extralobar pulmonary arteries was assessed by organ chamber technique...
June 15, 2018: Life Sciences
Mohamed E Abd El-Hack, Dalia H Samak, Ahmed E Noreldin, Muhammad Arif, Hilal S Yaqoob, Ayman A Swelum
Water represents 71% of all earth area and about 97% of this water is salty water. So, only 3% of the overall world water quantity is freshwater. Human can benefit only from 1% of this water and the remaining 2% freeze at both poles of earth. Therefore, it is important to preserve the freshwater through increasing the plants consuming salty water. The future prosperity of feed resources in arid and semi-arid countries depends on economic use of alternative resources that have been marginalized for long periods of time, such as halophytic plants, which are one such potential future resource...
May 2018: Environmental Science and Pollution Research International
Keyin Liu, Xiuqi Kong, Yanyan Ma, Weiying Lin
Carbon monoxide (CO) is a key gaseous signaling molecule in living cells and organisms. This protocol illustrates the synthesis of a highly sensitive Nile Red (NR)-Pd-based fluorescent probe, NR-PdA, and its applications for detecting endogenous CO in tissue culture cells, ex vivo organs, and zebrafish embryos. In the NR-PdA synthesis process, 3-diethylamine phenol reacts with sodium nitrite in the acidic condition to afford 5-(diethylamino)-2-nitrosophenol hydrochloride (compound 1), which is further treated with 1-naphthalenol at a high temperature to provide the NR dye via a cyclization reaction...
May 2018: Nature Protocols
Philipp A Pickerodt, Sebastian Kronfeldt, Martin Russ, Adrian Gonzalez-Lopez, Philipp Lother, Elvira Steiner, Katja Vorbrodt, Thilo Busch, Willehad Boemke, Roland C E Francis, Erik R Swenson
KEY POINTS: Carbonic anhydrase (CA) inhibitors such as acetazolamide inhibit hypoxic pulmonary vasoconstriction (HPV) in humans and other mammals, but the mechanism of this action remains unknown. It has been postulated that carbonic anhydrase may act as a nitrous anhydrase in vivo to generate nitric oxide (NO) from nitrite and that this formation is increased in the presence of acetazolamide. Acetazolamide reduces HPV in pigs without evidence of any NO generation, whereas nebulized sodium nitrite reduces HPV by NO formation; however; combined infusion of acetazolamide with sodium nitrite inhalation did not further increase exhaled NO concentration over inhaled nitrite alone in pigs exposed to alveolar hypoxia...
April 16, 2018: Journal of Physiology
Alessandra Borgognone, Eduard Shantsila, Sophie M Worrall, Eakkapote Prompunt, Thomas Loka, Brodie L Loudon, Myriam Chimen, G Ed Rainger, Janet M Lord, Ashley Turner, Peter Nightingale, Martin Feelisch, Paulus Kirchhof, Gregory Y H Lip, Steve P Watson, Michael P Frenneaux, Melanie Madhani
Aims: Heart failure (HF) is a pro-thrombotic state. Both platelet and vascular responses to nitric oxide (NO) donors are impaired in HF patients with reduced ejection fraction (HFrEF) compared to healthy volunteers (HV) due to scavenging of NO, and possibly also reduced activity of the principal NO sensor, soluble guanylate cyclase (sGC), limiting the therapeutic potential of NO donors as anti-aggregatory agents. Previous studies have shown that nitrite inhibits platelet activation presumptively after its reduction to NO, but the mechanism(s) involved remain poorly characterized...
April 12, 2018: Cardiovascular Research
Sima Jilanchi, Ardeshir Talebi, Mehdi Nematbakhsh
Background: Nephrotoxicity is one of the side effects of cisplatin (CP) therapy which is gender related. CP disturbs renal function through glomerular filtration rate and electrolytes transport disturbances. This study was designed to compare some markers related to renal function in two protocols of CP treatment in rats. Materials and Methods: Male and female rats were subjected to receive single (treat 1; 7.5 mg/kg) and continues doses (treat 2; 3 mg/kg/day for 5 days) of CP, and the measurements were compared with control animals...
2018: Advanced Biomedical Research
Limin Kung, Megan L Smith, Erica Benjamim da Silva, Michelle C Windle, Thiago C da Silva, Stephanie A Polukis
We evaluated the effectiveness of an additive comprising sodium benzoate, potassium sorbate, and sodium nitrite (SSL) as active ingredients for its ability to improve the aerobic stability of corn silages made in North America. In experiment 1, treatment with SSL (1.5 and 2.0 L/t) on whole-plant corn (WPC) was compared with treatment with an additive containing buffered propionic acid and citric acid (BPA; 2 L/t) on corn harvested at 32 and 38% DM and ensiled for 120 d. Silage treated with BPA was higher in ammonia-N and propionic acid relative to other treatments...
April 11, 2018: Journal of Dairy Science
Vivien Demeter-Haludka, Mária Kovács, Alexandra Petrus, Roland Patai, Danina M Muntean, László Siklós, Ágnes Végh
Background: We have previous evidence that in anesthetized dogs the inorganic sodium nitrite protects against the severe ventricular arrhythmias, resulting from coronary artery occlusion and reperfusion, when administered 24 h before. The present study aimed to examine, whether in this effect changes in mitochondrial morphology and function would play a role. Methods: Thirty dogs were infused intravenously either with saline ( n = 15) or sodium nitrite (0.2 μmol/kg/min; n = 15) for 20 min, and 24 h later, 10 dogs from each group were subjected to a 25 min period of occlusion and then reperfusion of the left anterior descending coronary artery...
2018: Frontiers in Pharmacology
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