Tanveer A Tabish, Mian Zahid Hussain, Sevasti Zervou, William K Myers, Weiming Tu, Jiabao Xu, Irina Beer, Wei E Huang, Rona Chandrawati, Mark J Crabtree, Paul G Winyard, Craig A Lygate
Nitric oxide (NO) is a key signalling molecule released by vascular endothelial cells that is essential for vascular health. Low NO bioactivity is associated with cardiovascular diseases, such as hypertension, atherosclerosis, and heart failure and NO donors are a mainstay of drug treatment. However, many NO donors are associated with the development of tolerance and adverse effects, so new formulations for controlled and targeted release of NO would be advantageous. Herein, we describe the design and characterisation of a novel NO delivery system via the reaction of acidified sodium nitrite with thiol groups that had been introduced by cysteamine conjugation to porous graphene oxide nanosheets, thereby generating S-nitrosated nanosheets...
April 4, 2024: Redox Biology