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https://www.readbyqxmd.com/read/29897540/laser-therapy-for-pediatric-burn-scars-focusing-on-a-combined-treatment-approach
#1
Jennifer Zuccaro, Inga Muser, Manni Singh, Janelle Yu, Charis Kelly, Joel Fish
Treatment with laser therapy has the potential to greatly improve hypertrophic scarring in individuals who have sustained burn injuries. More specifically, recent research has demonstrated the success of using pulsed dye laser therapy to help reduce redness and postburn pruritus and using ablative fractional CO2 laser therapy to improve scar texture and thickness. This study describes our early experience using laser therapy in our pediatric burn program and details our specific treatment approach when using each laser individually and in combination during the same procedure...
April 20, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29877309/usefulness-of-red-blood-cell-distribution-width-to-predict-heart-failure-hospitalization-in-patients-with-hypertrophic-cardiomyopathy
#2
Hong-Jie Yang, Xin Liu, Chuan Qu, Shao-Bo Shi, Jin-Jun Liang, Bo Yang
Red cell distribution width (RDW) has been associated with heart failure (HF) hospitalization in the general population, but the correlation to HF hospitalization in patients with hypertrophic cardiomyopathy (HCM) is unclear.Ninety-eight HCM patients without a history of HF were enrolled and RDW was assessed as a predictor.During a 16.8 ± 9.0 month follow-up period, 17 subjects were hospitalized due to HF. HF hospitalization patients had higher RDW than non-HF patients (14.7 ± 1.4% versus 13.0 ± 0.9%, P < 0...
June 6, 2018: International Heart Journal
https://www.readbyqxmd.com/read/29801713/awareness-of-fabry-disease-in-cardiology-a-gap-to-be-filled
#3
Dulce Brito, Nuno Cardim, Luís Rocha Lopes, Adriana Belo, Jorge Mimoso, Lino Gonçalves, Hugo Madeira
INTRODUCTION: In adults, unexplained left ventricular hypertrophy is usually due to sarcomeric hypertrophic cardiomyopathy (HCM). Fabry disease (FD) is rare but may mimic sarcomeric HCM, and has an adverse prognosis in the absence of specific treatment. We aimed to assess cardiologists' awareness of FD based on data from the Portuguese Registry of Hypertrophic Cardiomyopathy. METHODS: A total of 811 index patients, aged 55 ± 16 years, 486 (59.9%) male, were included...
May 22, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29718376/assessment-of-ablative-fractional-co2-laser-and-er-yag-laser-to-treat-hypertrophic-scars-in-a-red-duroc-pig-model
#4
Luis Rodriguez-Menocal, Stephen S Davis, Sandra Becerra, Marcela Salgado, Joel Gill, Jose Valdes, Ambar Candanedo, Shanmugasundaram Natesan, Michael Solis, Wellington Guzman, Alex Higa, Carl I Schulman, Robert J Christy, Jill Waibel, Evangelos V Badiavas
Hypertrophic scarring is a fibroproliferative process that occurs following a third-degree dermal burn injury, producing significant morbidity due to persistent pain, itching, cosmetic disfigurement, and loss of function due to contractures. Ablative fractional lasers have emerged clinically as a fundamental or standard therapeutic modality for hypertrophic burn scars. Yet the examination of their histopathological and biochemical mechanisms of tissue remodeling and comparison among different laser types has been lacking...
April 28, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/29661554/effect-of-skin-graft-thickness-on-scar-development-in-a-porcine-burn-model
#5
Danielle M DeBruler, Britani N Blackstone, Kevin L McFarland, Molly E Baumann, Dorothy M Supp, J Kevin Bailey, Heather M Powell
Animal models provide a way to investigate scar therapies in a controlled environment. It is necessary to produce uniform, reproducible scars with high anatomic and biologic similarity to human scars to better evaluate the efficacy of treatment strategies and to develop new treatments. In this study, scar development and maturation were assessed in a porcine full-thickness burn model with immediate excision and split-thickness autograft coverage. Red Duroc pigs were treated with split-thickness autografts of varying thickness: 0...
June 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29604078/maternal-undernutrition-in-late-gestation-increases-igf2-signalling-molecules-and-collagen-deposition-in-the-right-ventricle-of-the-fetal-sheep-heart
#6
Jack R T Darby, I Caroline McMillen, Janna L Morrison
KEY POINTS: This study investigates the impact of decreased fetal plasma glucose concentrations on the developing heart in late gestation, by subjecting pregnant ewes to a 50% global nutrient restriction. Late gestation undernutrition (LGUN) decreased fetal plasma glucose concentrations whilst maintaining a normoxemic blood gas status. LGUN increased the mRNA expression of IGF2 and IGF2R. Fetal plasma glucose concentrations, but not fetal blood pressure, were significantly correlated with IGF2 expression and the activation of CAMKII in the fetal right ventricle...
March 31, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29599211/experimental-right-ventricular-hypertension-induces-regional-%C3%AE-1-integrin-mediated-transduction-of-hypertrophic-and-profibrotic-right-and-left-ventricular-signaling
#7
Mei Sun, Ryo Ishii, Kenichi Okumura, Adrienn Krauszman, Siegfried Breitling, Olga Gomez, Aleksander Hinek, Stellar Boo, Boris Hinz, Kim A Connelly, Wolfgang M Kuebler, Mark K Friedberg
BACKGROUND: Development of right ventricular (RV) hypertension eventually contributes to RV and left ventricular (LV) myocardial fibrosis and dysfunction. The molecular mechanisms are not fully elucidated. METHODS AND RESULTS: Pulmonary artery banding was used to induce RV hypertension in rats in vivo. Then, we evaluated cardiac function and regional remodeling 6 weeks after pulmonary artery banding. To further elucidate mechanisms responsible for regional cardiac remodeling, we also mimicked RV hypertensive stress by cyclic mechanical stretching applied to confluent cultures of cardiac fibroblasts, isolated from the RV free wall, septal hinge points, and LV free wall...
March 29, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29392869/comparison-of-the-effectiveness-of-pulsed-dye-laser-vs-pulsed-dye-laser-combined-with-ultrapulse-fractional-co-2-laser-in-the-treatment-of-immature-red-hypertrophic-scars
#8
Hua-Wei Ouyang, Gao-Feng Li, Ying Lei, Michael H Gold, Jun Tan
INTRODUCTION: The objective was to investigate the clinical effect of an adjustable pulse width Pulsed Dye Laser (PDL) vs an adjustable pulse width PDL combined with fractional CO2 laser in treating immature red hypertrophic scars. METHODS: Fifty-six patients (56 sites)were randomly divided into a treatment group and control group. The control group was treated with the 595 nm PDL at a fluence of 7-15J/cm2 and pulse widths of 1.5-3 ms, 7 mm spot size. The treatment group was treated with a fractional CO2 laser (UltraPulse CO2 : Deep FX, Energy: 30~50 mJ, Frequency: 300 Hz, Density 5%, Scan Shape, and Spot Size were decided by shape and area of scar) after utilizing the 595 nm adjustable pulse width PDL (Fluence: 7-15J/cm2 , Pulse widths: 1...
February 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29392829/fibromodulin-reduces-scar-size-and-increases-scar-tensile-strength-in-normal-and-excessive-mechanical-loading-porcine-cutaneous-wounds
#9
Wenlu Jiang, Kang Ting, Soonchul Lee, Janette N Zara, Richard Song, Chenshuang Li, Eric Chen, Xinli Zhang, Zhihe Zhao, Chia Soo, Zhong Zheng
Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive-mechanical-loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule-fibromodulin (FMOD) protein-can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive-mechanical-loading red Duroc pig wound models...
April 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29375731/matrix-metalloproteinases-are-differentially-regulated-and-responsive-to-compression-therapy-in-a-red-duroc-model-of-hypertrophic-scar
#10
Taryn E Travis, Pejhman Ghassemi, Nicholas J Prindeze, Lauren T Moffatt, Bonnie C Carney, Abdulnaser Alkhalil, Jessica C Ramella-Roman, Jeffrey W Shupp
Objective: Proteins of the matrix metalloproteinases family play a vital role in extracellular matrix maintenance and basic physiological processes in tissue homeostasis. The function and activities of matrix metalloproteinases in response to compression therapies have yet to be defined. Here, a swine model of hypertrophic scar was used to profile the transcription of all known 26 matrix metalloproteinases in scars treated with a precise compression dose. Methods: Full-thickness excisional wounds were created...
2018: Eplasty
https://www.readbyqxmd.com/read/29356164/tracking-actinic-keratosis-of-face-and-scalp-treated-with-0-015-ingenol-mebutate-to-identify-clinical-and-dermoscopic-predictors-of-treatment-response
#11
R Pampena, E Benati, S Borsari, C Bombonato, M Lombardi, M Raucci, M Mirra, A Lallas, Z Apalla, I Papadimitriou, E Moscarella, A Kyrgidis, G Argenziano, G Pellacani, C Longo
BACKGROUND: Ingenol mebutate (IngMeb) 0.015% gel is an approved field treatment option for non-hyperkeratotic non-hypertrophic actinic keratosis (AK) of face and scalp. Efficacy of IngMeb has been assessed only on a clinical ground, in the majority of studies. Dermoscopy is a pivotal tool for the diagnosis of AK, while its role in evaluating the response to non-surgical therapies for AK has not been fully defined. OBJECTIVES: Our study aims to determine whether some dermoscopic features of AK of the face and scalp areas may independently predict the response to IngMeb therapy...
January 22, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29302675/copper-induced-reduction-in-myocardial-fibrosis-is-associated-with-increased-matrix-metalloproteins-in-a-rat-model-of-cardiac-hypertrophy
#12
Yinjie Liu, Ying Xiao, Jiaming Liu, Li Feng, Y James Kang
Trientine (TETA), a copper (Cu) chelator, is capable of replenishing Cu in the heart, and Cu repletion reduces cardiac fibrosis in a rodent model of cardiac hypertrophy. This study was undertaken to explore possible mechanisms by which Cu repletion diminishes cardiac fibrosis. Adult male Sprague-Dawley rats were subjected to ascending aortic constriction to induce cardiac hypertrophy. Four months after the operation, cardiac hypertrophy along with fibrosis was fully developed. TETA treatment was then followed at a dose of 21...
January 24, 2018: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/29204738/the-association-between-myocardial-fibrosis-and-depressed-capillary-density-in-rat-model-of-left-ventricular-hypertrophy
#13
Ying Xiao, Yinjie Liu, Jiaming Liu, Y James Kang
Myocardial fibrogenesis is initiated once the coordination between oxygen supply and demand is disrupted in pressure overload-induced cardiac hypertrophy. Clinical observations showed that myocardial fibrosis did not evenly occur in the hypertrophic myocardium. The present study was undertaken to specifically address differential vulnerabilities to fibrogenesis of different regions in the myocardium subjected to pressure overload-induced hypertrophy. SD rats were divided into two groups, sham-operated control and ascending artery constriction-induced cardiac hypotrophy...
December 4, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29174564/crispr-cas9-engineered-osteogenesis-imperfecta-type-v-leads-to-severe-skeletal-deformities-and-perinatal-lethality-in-mice
#14
Frank Rauch, Yeqing Geng, Lisa Lamplugh, Bahareh Hekmatnejad, Marie-Hélène Gaumond, Janice Penney, Yojiro Yamanaka, Pierre Moffatt
Osteogenesis imperfecta (OI) type V is caused by an autosomal dominant mutation in the IFITM5 gene, also known as BRIL. The c.-14C>T mutation in the 5'UTR of BRIL creates a novel translational start site adding 5 residues (MALEP) in frame with the natural coding of BRIL. A neomorphic function has been proposed for the MALEP-BRIL but the mechanisms at play are still unknown. In order to further understand the effects of MALEP-BRIL in vivo, we generated a knockin (KI) mouse model having the exact genetic -14C>T replica of patients with OI type V...
February 2018: Bone
https://www.readbyqxmd.com/read/29163221/the-superficial-dermis-may-initiate-keloid-formation-histological-analysis-of-the-keloid-dermis-at-different-depths
#15
Hu Jiao, Tiran Zhang, Jincai Fan, Ran Xiao
Several studies have reported on certain aspects of the characteristics of different sites within a keloid lesion, but detailed studies on the keloid dermis at different depths within a keloid lesion are scarce. The aim of this study was to investigate the histology of the keloid dermis at different depths. This study included 19 keloid tissue samples that were collected from 19 patients and 19 normal skin samples, which were harvested from subjects without keloids or hypertrophic scar. Samples were studied by light microscopy using routine hematoxylin and eosin histochemical staining, and immunohistochemistry to detect CD20-positive B-lymphocytes and CD3-positive T-lymphocytes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29143574/investigating-the-preventive-effects-of-baicalin-and-gallocatechin-against-glyoxal-induced-cystatin-aggregation
#16
Aamir Sohail, Waseem Feeroze Bhat, Sheraz Ahmad Bhat, Mohammad Furkan, Aaliya Shah, Bilqees Bano
Several mammalian proteins form pathological deposits under nonphysiological conditions that are associated with many degenerative diseases. Protein aggregation is associated with aging, as well as a variety of diseases, including cystic fibrosis, amyotrophic lateral sclerosis (ALS), and hypertrophic cardiomyopathy. There is a lack of any potential anti-amyloidogenic agents and therapeutics till date. Polyphenols have been accredited with myriad biological effects. An analysis of the effects of natural agents like baicalin (BC) and gallocatechin (GC) on aggregation process can open new avenues for the treatment of protein misfolding diseases...
November 30, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29141687/autologous-adipose-derived-regenerative-cell-therapy-modulates-development-of-hypertrophic-scarring-in-a-red-duroc-porcine-model
#17
Philippe Foubert, Diana Zafra, Mike Liu, Rohit Rajoria, Damian Gutierrez, Mayer Tenenhaus, John K Fraser
BACKGROUND: Effective prevention and treatment of hypertrophic scars (HTSs), a common consequence of deep-partial thickness injury, remain a significant clinical challenge. Previous studies from our group have shown that autologous adipose-derived regenerative cells (ADRCs) represent a promising approach to improve wound healing and, thereby, impact HTS development. The purpose of this study was to assess the influence of local delivery of ADRCs immediately following deep-partial thickness cutaneous injury on HTS development in the red Duroc (RD) porcine model...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29141064/port-wine-stains-a-focused-review-on-their-management
#18
Katelyn Mariko Updyke, Amor Khachemoune
<p>Port-wine stain (PWS) is the second most common congenital vascular malformation characterized as ectatic capillaries and venules in the dermis that clinically appears as a deep red to purple patch on the skin. Typically, PWS progressively darken and may become hypertrophic or nodular without treatment. There are several treatment options available for PWS from topical antiangiogenic agents to laser therapies. Vascular-specific lasers are the gold standard in treating PWS and classically pulsed dye lasers are usually the treatment of choice...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29067487/epigenetic-modifications-of-the-zfp-znf423-gene-control-murine-adipogenic-commitment-and-are-dysregulated-in-human-hypertrophic-obesity
#19
Michele Longo, Gregory A Raciti, Federica Zatterale, Luca Parrillo, Antonella Desiderio, Rosa Spinelli, Ann Hammarstedt, Shahram Hedjazifar, Jenny M Hoffmann, Cecilia Nigro, Paola Mirra, Francesca Fiory, Pietro Formisano, Claudia Miele, Ulf Smith, Francesco Beguinot
AIMS/HYPOTHESIS: Subcutaneous adipocyte hypertrophy is associated with insulin resistance and increased risk of type 2 diabetes, and predicts its future development independent of obesity. In humans, subcutaneous adipose tissue hypertrophy is a consequence of impaired adipocyte precursor cell recruitment into the adipogenic pathway rather than a lack of precursor cells. The zinc finger transcription factor known as zinc finger protein (ZFP) 423 has been identified as a major determinant of pre-adipocyte commitment and maintained white adipose cell function...
February 2018: Diabetologia
https://www.readbyqxmd.com/read/29055932/metastases-of-hepatocellular-carcinoma-misdiagnosed-as-isolated-hypertrophic-cardiomyopathy
#20
Assunta Greco, Roberto De Masi, Stefania Orlando, Antonio Metrangolo, Vittorio Zecca, Giancarlo Morciano, Antonella De Donno, Francesco Bagordo, Giancarlo Piccinni
At present, cardiac metastasis of hepatocellular carcinoma is rarely mentioned in the literature. We report a hepatocellular carcinoma patient with cardiac metastasis misdiagnosed as hypertrophic cardiomyopathy in 2011. Two years later, on presentation of syncope, an abnormal ventricular septal size was recorded by ultrasound scan, and was subsequently shown by magnetic resonance imaging to be a tumour lesion. A myocardial biopsy confirmed infiltration of hepatocellular carcinoma. This observation underlines the risk of hepatocellular carcinoma cardiac metastasis, manifested in its infiltrative form as hypertrophic cardiomyopathy...
November 2017: Annals of Hepatology
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