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https://www.readbyqxmd.com/read/28465251/danshen-injection-prevents-heart-failure-by-attenuating-post-infarct-remodeling
#1
Lingyan Wang, Jiahui Yu, Patrick Asare Fordjour, Xiaoxue Xing, Hui Gao, Yanyan Li, Lingyan Li, Yan Zhu, Xiumei Gao, Guanwei Fan
ETHNOPHARMACOLOGICAL RELEVANCE: Danshen Injection (DSI) is a traditional Chinese medicine extracted from Danshen, prepared from the dried root and rhizome of Salvia miltiorrhiza Bunge. Danshen is an ancient antipyretic traditional Chinese medicine which is mostly used to improve blood circulation and dispel blood stasis. Danshen decoction or liquor-fried Danshen (with grain-based liquor) which is cool in nature is traditionally used to 'cool the blood' and reduce the swelling of sores and abscesses...
April 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28384007/effect-of-chymase-activity-on-skin-thickness-in-the-clawn-miniature-pig-hypertrophic-scarring-model
#2
Shotaro Jimi, Hajime Matsumura
OBJECTIVE: The female red Duroc pig, a heavy and cumbersome animal, is routinely used as an animal model for hypertrophic scarring. Chymase, a chymotrypsin-like serine protease, plays an important role in skin fibrosis. This study aimed to create a lightweight pig hypertrophic scarring model using Clawn miniature pigs, and to investigate the role of chymase in hypertrophic scarring. METHODS: After creating four skin wounds (7.5 × 7.5 cm, depth = 0.15 cm) in each pig, skin biopsies were performed after 15, 30, 60, 90, 120, and 150 days...
April 6, 2017: Journal of Plastic Surgery and Hand Surgery
https://www.readbyqxmd.com/read/28293527/the-use-of-silgel-stc-se-a-topical-silicone-gel-for-the-treatment-and-reduction-of-hypertrophic-and-keloid-scars
#3
Sharon A Stewart, Greig M G Dougall, Erica M Tafuro
BACKGROUND: A single-center study assessing the efficacy of Nagor's Silgel STC-SE silicone gel to reduce the appearance of hypertrophic and keloid scars. METHODS: A 16-week controlled study of 36 patients with hypertrophic or keloid scars. The subjects were divided between 2 cohorts: one assessing recently healed scars (<6 mo) and other assessing older scars (6 mo to 2 y). The efficacy of Silgel STC-SE on the scar was evaluated by skin hydration, skin moisture evaporation, skin elasticity, basic scar measurements, subjective patient questionnaire data, and image analysis...
December 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28259957/photodynamic-inactivation-of-fibroblasts-and-inhibition-of-staphylococcus%C3%A2-epidermidis-adhesion-and-biofilm-formation-by-toluidine-blue-o
#4
Xin Li, Zizhong Liu, Houfang Liu, Xi Chen, Yue Liu, Honglue Tan
Treating skin and soft tissue infections of severe limb traumas can be challenging. Crucial concerns focus on inhibiting biofilm formation by antibiotic‑resistant bacteria, and preventing scar formation by fibroblastic hyperproliferation. The local use of toluidine blue O (TBO)‑mediated photodynamic therapy (PDT) may be a promising strategy for treating such lesions. The present study used Staphylococcus epidermidis (strain ATCC 35984) to assess the effects of TBO‑PDT on bacterial adherence and biofilm formation, using confocal laser scanning microscopy (CLSM), tissue culture plating (TCP) and scanning electron microscopy (SEM)...
April 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28256566/aberrant-epicardial-adipose-tissue-extracellular-matrix-remodeling-in-patients-with-severe-ischemic-cardiomyopathy-insight-from-comparative-quantitative-proteomics
#5
Ding-Sheng Jiang, Hao-Long Zeng, Rui Li, Bo Huo, Yun-Shu Su, Jing Fang, Qing Yang, Li-Gang Liu, Min Hu, Cai Cheng, Xue-Hai Zhu, Xin Yi, Xiang Wei
There is ample evidence indicating that epicardial adipose tissue (EAT) volume and thickness is positively associated with coronary artery disease (CAD). However, the exact pathological changes in the human EAT after myocardial ischemia remains largely unclear. In the current study, we applied a comparative quantitative proteomics to elucidate the altered biological processes in the EAT of ischemic cardiomyopathy (ICM) patients. A total of 1649 proteins were successfully quantified in our study, among which 165 proteins were significantly changed (ratio <0...
March 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28247932/the-dentato-rubro-olivary-pathway-revisited-new-mr-imaging-observations-regarding-hypertrophic-olivary-degeneration
#6
Gitte Smets, Julie Lambert, Maud Tijssen, Cindy Mai, Thomas Decramer, Wim Vandenberghe, Johannes Van Loon, Philippe Demaerel
INTRODUCTION: Hypertrophic olivary degeneration (HOD) following a lesion of the dentato-rubro-olivary pathway (DROP) is a well-known imaging finding and has extensively been described in the recent literature. MATERIAL AND METHODS: We reviewed our patients with HOD as a result of a lesion of the DROP in order to analyze the disruption of the DROP and the resulting HOD in comparison with the literature. RESULTS: We observed unusual imaging findings in four patients...
March 1, 2017: Clinical Anatomy
https://www.readbyqxmd.com/read/28180922/effect-of-btxa-on-inhibiting-hypertrophic-scar-formation-in-a-rabbit-ear-model
#7
Dong-Qing Liu, Xiao-Jing Li, Xiao-Juan Weng
BACKGROUND: Hypertrophic scar (HS) is a refractory skin disease caused by major physical damage or other inflammation. Some reports found that botulinum toxin type A (BTXA) could be an alternative treatment of the HS. Therefore, the authors studied the effects of BTXA on the treatment of HS and the dose response of BTXA. METHODS: Hypertrophic scars were harvested from the ears of 18 young adult New Zealand big-eared rabbits and treated with BTXA or triamcinolone acetonide (TAC) in vivo experiment...
February 8, 2017: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28153584/assessing-blood-flow-microvasculature-erythema-and-redness-in-hypertrophic-scars-a-cross-sectional-study-showing-different-features-that-require-precise-definitions
#8
M E H Jaspers, C M Stekelenburg, J M Simons, K M Brouwer, M Vlig, E van den Kerckhove, E Middelkoop, P P M van Zuijlen
BACKGROUND: In hypertrophic scar assessment, laser Doppler imaging (LDI), colorimetry and subjective assessment (POSAS) can be used to evaluate blood flow, erythema and redness, respectively. In addition, the microvasculature (i.e. presence of microvessels) can be determined by immunohistochemistry. These measurement techniques are frequently used in clinical practice and/or in research to evaluate treatment response and monitor scar development. However, until now it has not been tested to what extent the outcomes of these techniques are associated, whilst the outcome terms are frequently used interchangeably or replaced by the umbrella term 'vascularization'...
January 30, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28139503/endoscopic-resection-of-asymptomatic-colonic-polypoid-arteriovenous-malformations-two-case-reports-and-a-literature-review
#9
Han-Hee Lee, Hyuk-Min Kwon, Sanghyun Gil, Young-Shin Kim, Minjung Cho, Kyung-Jin Seo, Hiun-Suk Chae, Young-Seok Cho
A colonic arteriovenous malformation (AVM) is a significant vascular lesion of the gastrointestinal tract and a common cause of lower gastrointestinal bleeding. AVMs are usually identified endoscopically as bright red, flat lesions. AVMs with a polypoid appearance are extremely rare in the large intestine. We present two cases of colonic polypoid AVM, which were detected incidentally during screening colonoscopy. Both the patients had no history of gastrointestinal bleeding such as melena or hematochezia. Colonoscopy revealed pedunculated polyps overlaid by hyperemic mucosa in the ascending colon and proximal sigmoid colon...
January 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/28077803/gerosuppression-by-pan-mtor-inhibitors
#10
Olga V Leontieva, Mikhail V Blagosklonny
Rapamycin slows organismal aging and delays age-related diseases, extending lifespan in numerous species. In cells, rapamycin and other rapalogs such as everolimus suppress geroconversion from quiescence to senescence. Rapamycin inhibits some, but not all, activities of mTOR. Recently we and others demonstrated that pan-mTOR inhibitors, known also as dual mTORC1/C2 inhibitors, suppress senescent phenotype. As a continuation of these studies, here we investigated in detail a panel of pan-mTOR inhibitors, to determine their optimal gerosuppressive concentrations...
December 30, 2016: Aging
https://www.readbyqxmd.com/read/28054644/the-effectiveness-of-pressure-therapy-15-25%C3%A2-mmhg-for-hypertrophic-burn-scars-a-systematic-review-and-meta-analysis
#11
Jin-Wei Ai, Jiang-Tao Liu, Sheng-Duo Pei, Yu Liu, De-Sheng Li, Hong-Ming Lin, Bin Pei
Although pressure therapy (PT) represents the standard care for prevention and treatment of hypertrophic scar (HS) from burns, its practice is largely based on empirical evidence and its effectiveness remains controversial. To clarify the effect of PT (15-25 mmHg) for HS, we performed the systematic review and meta-analysis. Several electronic databases were screened to identify related randomized controlled trials (RCTs). 12 RCTs involving 710 patients with 761 HS resulting from burn injuries were included...
January 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27860441/effects-of-human-chorionic-gonadotropin-on-testicular-interstitial-tissues-in-men-with-non-obstructive-azoospermia
#12
S Oka, K Shiraishi, H Matsuyama
Non-obstructive azoospermia is a severe condition because spermatogenesis per se is disrupted. Although microdissection testicular sperm extraction is the standard therapy for non-obstructive azoospermia, sperm retrieval is unsuccessful in approximately 50% of patients. For these patients, we conducted human chorionic gonadotropin-based salvage hormonal therapy, and sperm retrieval was possible in 10-20% of patients. The objectives of this study were to assess the changes in interstitial lesions in patients with non-obstructive azoospermia and to evaluate the effects of human chorionic gonadotropin on these tissues...
March 2017: Andrology
https://www.readbyqxmd.com/read/27779914/estradiol-synthesis-in-gut-associated-lymphoid-tissue-leukocyte-regulation-by-a-sexually-monomorphic-system
#13
Oliver R Oakley, Kee Jun Kim, Po-Ching Lin, Radwa Barakat, Joseph A Cacioppo, Zhong Li, Alexandra Whitaker, Kwang Chul Chung, Wenyan Mei, CheMyong Ko
17β-estradiol is a potent sex hormone synthesized primarily by gonads in females and males that regulates development and function of the reproductive system. Recent studies show that 17β-estradiol is locally synthesized in nonreproductive tissues and regulates a myriad of events, including local inflammatory responses. In this study, we report that mesenteric lymph nodes (mLNs) and Peyer's patches (Pps) are novel sites of de novo synthesis of 17β-estradiol. These secondary lymphoid organs are located within or close to the gastrointestinal tract, contain leukocytes, and function at the forefront of immune surveillance...
December 2016: Endocrinology
https://www.readbyqxmd.com/read/27765090/-effects-of-severe-hypoxia-and-low-concentration-of-serum-protein-on-the-function-of-human-hypertrophic-scar-fibroblasts
#14
J Y Dong, F Song, Y K Liu, X Q Wang
Objective: To simulate the environmental factors during the process of formation and evolution of hypertrophic scar, so as to explore the effects of moderate and severe hypoxia and low concentration of serum protein on the function of human hypertrophic scar fibroblasts (HSFs). Methods: Human HSFs were routinely cultured. Cells of the 3rd to the 6th passage were divided into 10.0% oxygen+ 10.0% fetal calf serum (FCS), 5.0% oxygen+ 5.0% FCS, and 0.5% oxygen+ 0.5% FCS groups according to the random number table...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27765087/-wound-healing-is-still-a-game-of-blind-men-and-an-elephant
#15
C M Han
The wound healing includes non-healing and overhealing of the wounds. The results of wound healing are well known by people such as non-healing of the diabetic ulcer or hypertrophic scar after deep burn. In this issue, three papers involve in wound healing, one about autologous adipose-derived mesenchymal stem cells injected into wound or scar of rabbit ear, one about severe hypoxia and hypoalbuminemia inducing human hypertrophic scar derived fibroblast apoptosis in vitro, and another about the dysfunction of protein kinase B/mammalian target of rapamycin signaling pathway contributing to the pathophysiological characteristics of diabetic skin and non-healing wound...
October 20, 2016: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/27734380/cell-biological-assays-for-measuring-chondrogenic-activities-of-ccn2-protein
#16
Takashi Nishida, Satoshi Kubota, Masaharu Takigawa
Growth-plate chondrocytes undergo proliferation, maturation, hypertrophic differentiation, and calcification; and these processes can be reproduced in vitro in a chondrocyte culture system. Using this system, we have shown that CCN family protein 2/connective tissue growth factor (CCN2/CTGF) promotes all stages of proliferation, maturation, hypertrophic differentiation, and calcification, thus suggesting that CCN2 is a multifunctional growth factor for chondrocytes and plays important roles in chondrocyte proliferation and differentiation...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27691948/radiographic-thoracic-anatomy-of-the-red-panda-ailurus-fulgens
#17
Modesta Makungu, Wencke M du Plessis, Michelle Barrows, Hermanus B Groenewald, Katja N Koeppel
The red panda ( Ailurus fulgens ) is classified as an endangered species by the International Union for Conservation of Nature and Natural Resources. The natural distribution of the red panda is in the Himalayas and southern China. Thoracic diseases such as dirofilariasis, hypertrophic cardiomyopathy, tracheal obstruction, lung worm infestation, and pneumonia have been reported in the red panda. The aim of this study was to describe the normal radiographic thoracic anatomy of captive red pandas as a species-specific reference for routine health examinations and clinical cases...
September 2016: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/27613920/association-of-exercise-training-with-tobacco-smoking-prevents-fibrosis-but-has-adverse-impact-on-myocardial-mechanics
#18
Dermeval Reis Junior, Ednei Luiz Antonio, Marcello Fabiano de Franco, Helenita Antonia de Oliveira, Paulo José Ferreira Tucci, Andrey Jorge Serra
INTRODUCTION: There was no data for cardiac repercussion of exercise training associated with tobacco smoking. This issue is interesting because some smoking people can be enrolled in an exercise-training program. Thus, we evaluated swimming training effects on the function and structural myocardial in rats exposed to tobacco smoking. METHODS: Male Wistar rats were assigned to one of four groups: C, untrained rats without exposure to tobacco smoking; E, exercised rats without exposure to tobacco smoking; CS, untrained rats exposed to tobacco smoking; ECS, exercised rats exposed to tobacco smoking...
December 2016: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/27612513/skeletal-muscle-growth-dynamics-and-the-influence-of-first-feeding-diet-in-atlantic-cod-larvae-gadus-morhua-l
#19
Tu A Vo, Trina F Galloway, Tora Bardal, Christine K Halseth, Gunvor Øie, Elin Kjørsvik
Dynamics between hypertrophy (increase in cell size) and hyperplasia (increase in cell numbers) of white and red muscle in relation to body size [standard length (SL)], and the influence of the first-feeding diets on muscle growth were investigated in Atlantic cod larvae (Gadus morhua). Cod larvae were fed copepod nauplii or rotifers of different nutritional qualities from 4 to 29 days post hatching (dph), Artemia nauplii from 20 to 40 dph and a formulated diet from 36 to 60 dph. The short period of feeding with cultivated copepod nauplii had a positive effect on both muscle hyperplasia and hypertrophy after the copepod/rotifer phase (19 dph), and a positive long term effect on muscle hypertrophy (60 dph)...
November 15, 2016: Biology Open
https://www.readbyqxmd.com/read/27574672/the-molecular-basis-of-hypertrophic-scars
#20
REVIEW
Zhensen Zhu, Jie Ding, Edward E Tredget
Hypertrophic scars (HTS) are caused by dermal injuries such as trauma and burns to the deep dermis, which are red, raised, itchy and painful. They can cause cosmetic disfigurement or contractures if craniofacial areas or mobile region of the skin are affected. Abnormal wound healing with more extracellular matrix deposition than degradation will result in HTS formation. This review will introduce the physiology of wound healing, dermal HTS formation, treatment and difference with keloids in the skin, and it also review the current advance of molecular basis of HTS including the involvement of cytokines, growth factors, and macrophages via chemokine pathway, to bring insights for future prevention and treatment of HTS...
2016: Burns and trauma
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