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soft tissue sarcoma of head and neck

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https://www.readbyqxmd.com/read/29752328/soft-tissue-sarcoma-version-2-2018-nccn-clinical-practice-guidelines-in-oncology
#1
Margaret von Mehren, R Lor Randall, Robert S Benjamin, Sarah Boles, Marilyn M Bui, Kristen N Ganjoo, Suzanne George, Ricardo J Gonzalez, Martin J Heslin, John M Kane, Vicki Keedy, Edward Kim, Henry Koon, Joel Mayerson, Martin McCarter, Sean V McGarry, Christian Meyer, Zachary S Morris, Richard J O'Donnell, Alberto S Pappo, I Benjamin Paz, Ivy A Petersen, John D Pfeifer, Richard F Riedel, Bernice Ruo, Scott Schuetze, William D Tap, Jeffrey D Wayne, Mary Anne Bergman, Jillian L Scavone
Soft tissue sarcomas (STS) are rare solid tumors of mesenchymal cell origin that display a heterogenous mix of clinical and pathologic characteristics. STS can develop from fat, muscle, nerves, blood vessels, and other connective tissues. The evaluation and treatment of patients with STS requires a multidisciplinary team with demonstrated expertise in the management of these tumors. The complete NCCN Guidelines for STS provide recommendations for the diagnosis, evaluation, and treatment of extremity/superficial trunk/head and neck STS, as well as intra-abdominal/retroperitoneal STS, gastrointestinal stromal tumors, desmoid tumors, and rhabdomyosarcoma...
May 2018: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/29745023/interstitial-brachytherapy-for-pediatric-soft-tissue-sarcoma-evolving-practice-over-three-decades-and-long-term-outcomes
#2
Siddhartha Laskar, Avinash Pilar, Nehal Khanna, Ajay Puri, Ashish Gulia, Sajid Qureshi, Girish Chinnaswamy, Tushar Vora, Mukta Ramadwar
PURPOSE: Evaluate long-term clinical outcomes, adverse effects, and evolving practice of interstitial brachytherapy (BT) for pediatric soft tissue sarcomas (STS). METHODS: From September 1984 to December 2014, 105 children (median age 10 years) were included. There were 60 males and 45 females. The majority (74%) had primary lesions. Synovial sarcoma (22%) was the most frequent histology. Treatment included wide local excision and BT with or without external beam radiotherapy (EBRT)...
May 10, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29733909/radiosensitivity-of-lung-metastases-by-primary-histology-and-implications-for-stereotactic-body-radiation-therapy-using-the-genomically-adjusted-radiation-dose
#3
Kamran A Ahmed, Jacob G Scott, John A Arrington, Arash O Naghavi, G Daniel Grass, Bradford A Perez, Jimmy J Caudell, Anders E Berglund, Eric A Welsh, Steven A Eschrich, Thomas J Dilling, Javier F Torres-Roca
INTRODUCTION: We assessed the radiosensitivity of lung metastases based on primary histology using a validated gene signature and model lung metastases for the genomically adjusted radiation dose (GARD). METHODS: Tissue samples were identified from our prospective observational protocol. The radiosensitivity index (RSI) 10 gene assay was run on samples and calculated alongside GARD using the previously published algorithms. A cohort of 105 patients with 137 lung metastases treated with SBRT at our institution was used for clinical correlation...
May 4, 2018: Journal of Thoracic Oncology
https://www.readbyqxmd.com/read/29700887/cic-nutm1-fusion-a-case-which-expands-the-spectrum-of-nut-rearranged-epithelioid-malignancies
#4
Inga-Marie Schaefer, Paola Dal Cin, Christopher D M Fletcher, Glenn J Hanna, Christopher A French
NUT carcinoma (NC) shows very aggressive clinical behavior, occurs predominantly in the thorax and head and neck region of children and adults, and is defined by the presence of NUT (aka NUTM1) rearrangement, mostly BRD4-NUTM1 fusion resulting from t(15;19)(q13, p13.1). So-called "NUT variants" harbor alternate fusions between NUTM1 and BRD3, NSD3, ZNF532, or unknown partners. Rare cases of pediatric tumors with CIC-NUTM1 fusion were recently reported in somatic soft tissue, brain, and kidney. However, such cases have not been identified in adult patients and the presence of a fusion between CIC, characteristic of CIC-rearranged sarcoma, and NUTM1, a defining feature of NC - poses a diagnostic challenge...
April 26, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29696477/imaging-features-of-benign-mass-lesions-in-the-nasal-cavity-and-paranasal-sinuses-according-to-the-2017-who-classification
#5
REVIEW
Hiroyuki Tatekawa, Taro Shimono, Masahiko Ohsawa, Satoshi Doishita, Shinichi Sakamoto, Yukio Miki
The World Health Organization (WHO) 2017 classification of head and neck tumors has been just published and has reorganized tumors of the nasal cavity and paranasal sinuses. In this classification, three new entities (seromucinous hamartoma, NUT carcinoma, and biphenotypic sinonasal sarcoma) were included, while the total number of tumors has been reduced by excluding tumors if they did not occur exclusively or predominantly in this region. Among these entities, benign tumors were classified as sinonasal papillomas, respiratory epithelial lesions, salivary gland tumors, benign soft tissue tumors, or other tumors...
April 25, 2018: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29587522/surgical-treatment-of-pulmonary-metastasis-report-from-a-tertiary-care-center
#6
Waleed Saleh, Abdullah AlShammari, Jumana Sarraj, Omniyah AlAshgar, Mohamed Hussein Ahmed, Khaled AlKattan
Objective This retrospective analysis aimed to determine the factors influencing prognosis in adult patients who presented to our thoracic surgery service with lung metastases and were eligible for pulmonary metastasectomy. Methods We retrospectively reviewed the data of 296 patients who underwent resection of 575 lung metastases from January 2000 to January 2016. Univariate and multivariate analyses were performed based on age, sex, histology of the primary tumor, disease-free interval, number and size of metastases...
January 1, 2018: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/29563744/solitary-primary-intraosseous-angiosarcoma-of-the-mandible
#7
Arvind Krishnamurthy
Angiosarcoma is a malignant vascular tumor derived from the mesenchymal cells which have undergone an angioblastic differentiation. About half of the angiosarcomas are reported to localize in the skin and soft tissues of the head and neck, i.e., found predominantly to arise from the scalp and face. Angiosarcomas rarely involve the skeletal system, wherein they generally have a tendency for multicentricity. Primary bony angiosarcoma accounts for about 6% of all the angiosarcomas and about 1.4% of all the primary bony sarcomas...
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29563737/a-rare-presentation-of-synovial-sarcoma-as-cervical-lymphadenopathy-in-a-pediatric-patient-a-case-report
#8
Ashutosh Gupta, Gunjan Agrawal, Vivek Chaudhary, Heena Mazhar, Santanu Tiwari
Synovial sarcoma is the uncommon malignant tumor of children and adolescents. It usually involves the soft tissues of the upper and lower joints and most commonly affects adults in their fourth decade of life. We report a rare case of synovial sarcoma of the head and neck region in a five-year-old child who has presented with right side cervical lymphadenopathy associated with dysphagia and hoarseness of voice. Patient was managed by modified radical neck dissection followed by chemotherapy.
March 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29509716/risk-factors-including-age-stage-and-anatomic-location-that-impact-the-outcomes-of-patients-with-synovial-sarcoma
#9
Minggui Pan, Maqdooda Merchant
Synovial sarcoma is a high-grade soft tissue sarcoma that inflicts mostly children and young adults with high mortality rate; however, the risk factors that impact the outcomes remain incompletely understood. We have identified the synovial sarcoma cases from the Kaiser Permanente Northern California cancer registry between 1981 and 2014. Kaplan-Meier plots were used to display disease-free survival (DFS) and overall survival (OS); log-rank tests and Cox proportional hazard models were used to determine the impact of clinical factors on DFS, OS, and disease-specific survival...
March 6, 2018: Medical Sciences: Open Access Journal
https://www.readbyqxmd.com/read/29416348/synovial-sarcoma-of-the-maxillary-sinus-an-extremely-rare-case-with-excellent-response-to-chemotherapy
#10
Shin Saito, Hiroyuki Ozawa, Yuuichi Ikari, Nana Nakahara, Fumihiro Ito, Mariko Sekimizu, Junichi Fukada, Kaori Kameyama, Kaoru Ogawa
This paper presents an extremely rare case of synovial sarcoma arising from the maxillary sinus, which resulted in a clinically complete response to chemotherapy. Synovial sarcoma is a rare soft tissue malignant tumor, most commonly affecting the extremities. While ~10% occur in the head and neck region, synovial sarcoma of the sinonasal tract is extremely rare, with only 11 cases having been reported previously. As with other sarcomas, the standard treatment is complete resection while allowing for a safe margin, but this is often difficult in the head and neck area due to the complicated anatomy there...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29390454/low-grade-myofibroblastic-sarcoma-of-the-orbit-a-case-report-and-literature-review
#11
REVIEW
Shikun Zhang, Ying Ma, Tie Ma, Zhiming Wang
RATIONALE: Low-grade myofibroblastic sarcoma (LGMS) is a malignant lesion composed of myofibroblasts. It is an uncommon tumor of unknown etiology that mainly develops in the bone or soft tissue and is most often reported in the head and neck, particularly in the tongue and oral cavity. PATIENT CONCERNS: A 2-year-old girl, previously well and with no significant medical history or family history of other diseases, presented with a 2-week painless swelling of the right orbit...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374738/which-primary-organ-is-most-suitable-for-performing-pulmonary-metastasectomy
#12
Fumihiko Hirai, Ikuhiko Kinoshita, Taichi Matsubara, Naoki Haratake, Yuka Kouzuma, Shinkichi Takamori, Takai Akamine, Gouji Toyokawa, Tetsuzo Tagawa, Mitsuhiro Takenoyama, Yoshihiko Maehara
BACKGROUND/AIM: The aim of this study was to assess the appropriateness of pulmonary metastasectomy (MT), with a focus on the primary organ. PATIENTS AND METHODS: The pathological status of the primary organ, outcome of the MT, disease-free interval, and overall survival were assessed. RESULTS: The primary organ was the most significant prognostic factor analyzed, with a relative risk of 4.6 (95% confidence interval: 1.69-12.56, p=0.003). Patients with colorectal carcinoma had a better survival than those with another primary organ (p=0...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29369206/low-grade-myofibroblastic-sarcoma-of-gastric-cardia-on-18f-fdg-positron-emission-tomography-computed-tomography-an-extremely-rare-case-report
#13
Rong Niu, Jian-Feng Wang, Da-Chuan Zhang, Xiao-Liang Shao, Chun Qiu, Yue-Tao Wang
RATIONALE: Low-grade myofibroblastic sarcoma (LGMS) is a rare mesenchyme-derived tumor, which usually occurs in head, neck (especially tongue and mouth), and limbs. In this report, we described a case of gastric LGMS by F-fluoro-2-deoxy-d-glucose (FDG) positron emission tomography/computed tomography (PET/CT), which has not been reported previously. PATIENT CONCERNS: A 51-year-old female patient was admitted to our hospital with upper abdominal discomfort for 1 year and gradually increased eating difficulties over the last 3 months...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29325251/-extrapleural-solitary-fibrous-tumor-with-uncommon-histology-a-clinicopathologic-analysis-of-7-cases
#14
M Zhao, Z R Yang, Y B Wang, Y Chen, G W Qi, Y J Yan, W J Xu, G Q Ru, X L He
Objective: To investigate the clinicopathologic characteristics, immunophenotypes, and differential diagnostic features of extra-pleural solitary fibrous tumor (SFT) with uncommon histology. Methods: Seven cases of extra-pleural SFT with uncommon histology were collected during January 2015 and December 2016 in Zhejiang Provincal People's Hospital; the clinical and radiologic features, histomorphology, immunophenotype and prognosis were analyzed. EnVision method was used for immunohistochemical staining of STAT6, CD34 and other differential diagnosis associated markers...
January 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29316425/hedgehog-pathway-drives-fusion-negative-rhabdomyosarcoma-initiated-from-non-myogenic-endothelial-progenitors
#15
Catherine J Drummond, Jason A Hanna, Matthew R Garcia, Daniel J Devine, Alana J Heyrana, David Finkelstein, Jerold E Rehg, Mark E Hatley
Rhabdomyosarcoma (RMS) is a pediatric soft tissue sarcoma that histologically resembles embryonic skeletal muscle. RMS occurs throughout the body and an exclusively myogenic origin does not account for RMS occurring in sites devoid of skeletal muscle. We previously described an RMS model activating a conditional constitutively active Smoothened mutant (SmoM2) with aP2-Cre. Using genetic fate mapping, we show SmoM2 expression in Cre-expressing endothelial progenitors results in myogenic transdifferentiation and RMS...
January 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29285193/orbital-alveolar-soft-part-sarcoma-a-report-of-8-cases-and-review-of-the-literature
#16
Yan Hei, Li Kang, Xinji Yang, Yi Wang, Xiaozhong Lu, Yueyue Li, Wei Zhang, Lihua Xiao
Alveolar soft part sarcoma (ASPS) is a rare soft tissue neoplasm. The incidence of orbital involvement is the highest in ASPS arising in the head and neck region. However, limited information is available regarding its clinical characteristics. The present study presents the clinical manifestations, imaging findings, pathological features, treatment strategies and prognosis records of 8 cases of orbital ASPS over the last 15 years in a single hospital, along with a review of the literature. Included were 3 male and 5 female patients, with the median age at presentation being 9...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29283939/rabdomyosarcoma-of-the-mandible-an-uncommon-clinical-presentation
#17
Cleverton Roberto de Andrade, Guilherme Dos Santos Trento, Fabiano Jeremias, Elisa Maria Aparecida Giro, Marisa Aparecida Cabrini Gabrielli, Mario Francisco Real Gabrielli, Oslei Paes de Almeida, Valfrido Antonio Pereira-Filho
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. Most patients present with a mass in the head and neck region, urogenital region, or with distal extremity involvement. The authors describe a challenging case of a 6-year-old male patient presenting with mandibular RMS. The clinical/radiographic/tomographic evaluations classified the tumor as an advanced stage (stage IV), with a mass of 6.0 cm involving the left side of the mandible and parotid region. The biopsy revealed round, spindled, and pleomorphic cells with hyperchromatic nuclei and rare larger rhabdomyoblasts with eosinophilic cytoplasm...
December 27, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29274042/sclerosing-epithelioid-fibrosarcoma-of-the-jaw-late-recurrence-from-a-low-grade-fibromyxoid-sarcoma
#18
Catherine Laliberte, Iona T Leong, Howard Holmes, Eric A Monteiro, Brian O'Sullivan, Brendan C Dickson
Sclerosing epithelioid fibrosarcoma (SEF) is an uncommon variant of fibrosarcoma that is characterized by a distinct morphology. It most frequently presents in the deep soft tissues of the lower extremities, often in intimate association with fascia and periosteum, although reports of the head and neck involvement have been reported. A minority of cases show morphological, immunohistochemical and molecular overlap with low grade fibromyxoid sarcoma (LG-FMS). Herein, we describe a case of a bland spindle cell neoplasm presenting in the jaw that was initially incompletely excised...
December 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29259650/cytologic-features-of-primary-monophasic-synovial-sarcoma-of-the-thyroid-gland
#19
Chang-Soo Park, Young Kim, Eun-Hui Jeong, Nah-Ihm Kim, Yoo-Duk Choi
Synovial sarcoma (SS) is a rare soft tissue tumor, commonly arising in para-articular areas of extremities, but can also present in the head and neck area. However, primary SS of the thyroid gland is an extremely rare tumor which has been reported only five times in previous English literatures. This report presents fine needle aspiration (FNA) cytology of primary monophasic SS of the thyroid gland. A 47-year- old woman incidentally detected thyroid nodule in the isthmus of right thyroid gland on an ultrasonography by regular health check-up...
2017: CytoJournal
https://www.readbyqxmd.com/read/29212506/chromosome-9p-copy-number-gains-involving-pd-l1-are-associated-with-a-specific-proliferation-and-immune-modulating-gene-expression-program-active-across-major-cancer-types
#20
Jan Budczies, Carsten Denkert, Balázs Győrffy, Peter Schirmacher, Albrecht Stenzinger
BACKGROUND: Inhibition of the PD-L1/PD-1 immune checkpoint axis represents one of the most promising approaches of immunotherapy for various cancer types. However, immune checkpoint inhibition is successful only in subpopulations of patients emphasizing the need for powerful biomarkers that adequately reflect the complex interaction between the tumor and the immune system. Recently, recurrent copy number gains (CNG) in chromosome 9p involving PD-L1 were detected in many cancer types including lung cancer, melanoma, bladder cancer, head and neck cancer, cervical cancer, soft tissue sarcoma, prostate cancer, gastric cancer, ovarian cancer, and triple-negative breast cancer...
December 6, 2017: BMC Medical Genomics
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