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https://www.readbyqxmd.com/read/27769921/oral-nitrite-circumvents-antiseptic-mouthwash-induced-disruption-of-enterosalivary-circuit-of-nitrate-and-promotes-nitrosation-and-blood-pressure-lowering-effect
#1
Lucas C Pinheiro, Graziele C Ferreira, Jefferson H Amaral, Rafael L Portella, Sandra de O C Tella, Madla A Passos, Jose E Tanus-Santos
The nitric oxide (NO(•)) metabolites nitrite and nitrate exert antihypertensive effects by mechanisms that involve gastric formation of S-nitrosothiols. However, while the use of antiseptic mouthwash (AM) is known to attenuate the responses to nitrate by disrupting its enterosalivary cycle, there is little information about whether AM attenuates the effects of orally administered nitrite. We hypothesized that the antihypertensive effects of orally administered nitrite would not be prevented by AM because, in contrast to oral nitrate, oral nitrite could promote S-nitrosothiols formation in the stomach without intereference by AM...
October 18, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27739796/avalanches-and-force-drops-in-displacement-driven-compression-of-porous-glasses
#2
Víctor Navas-Portella, Álvaro Corral, Eduard Vives
Similarities between force-driven compression experiments of porous materials and earthquakes have been recently proposed. In this paper, we measure the acoustic emission during displacement-driven compression of a porous glass. The energy of acoustic-emission events shows that the failure process exhibits avalanche scale-invariance and therefore follows the Gutenberg-Richter law. The resulting exponents do not exhibit significant differences with respect the force-driven case. Furthermore, the force exhibits an avalanche-type behavior for which the force drops are power-law distributed and correlated with the acoustic emission events...
September 2016: Physical Review. E
https://www.readbyqxmd.com/read/27730634/eco-morphological-attributes-and-feeding-habits-in-coexisting-characins
#3
T Portella, J Lobón-Cerviá, L R Manna, H G Bergallo, R Mazzoni
The head morphology and feeding habits of pairs of characin species (family Characidae) that coexist in four different coastal rainforest streams were analysed. Coexisting species differed in size, but were very similar in eco-morphological attributes. Gut analyses revealed differences in feeding preferences for each coexisting species, indicating resource partitioning. A pattern of organization in species pairs that was repeated in the four studied streams was noticed. The pattern consisted of one slightly larger species with a feeding preference for items of allochthonous origin and another smaller species with a preference for autochthonous items...
October 12, 2016: Journal of Fish Biology
https://www.readbyqxmd.com/read/27592139/a-preliminary-longitudinal-study-on-the-cognitive-and-functional-outcome-of-bipolar-excellent-lithium-responders
#4
E Mora, M J Portella, I Forcada, E Vieta, M Mur
BACKGROUND: Neurocognitive dysfunction in bipolar disorder represents a possible marker of underlying pathophysiology, but to date, most studies are cross-sectional and heterogeneous with regard to pharmacological treatments. In the present study we investigated the 6-year cognitive and functional outcome of a sample of euthymic excellent lithium responders (ELR). METHOD: A total sample of twenty subjects was assessed at baseline and 6years later: ten diagnosed of bipolar disorder according to DSM-IV criteria and ten healthy matched controls...
July 30, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27571038/exploring-the-n-terminal-region-of-c-x-c-motif-chemokine-12-cxcl12-identification-of-plasma-stable-cyclic-peptides-as-novel-potent-c-x-c-chemokine-receptor-type-4-cxcr4-antagonists
#5
Salvatore Di Maro, Anna Maria Trotta, Diego Brancaccio, Francesco Saverio Di Leva, Valeria La Pietra, Caterina Ieranò, Maria Napolitano, Luigi Portella, Crescenzo D'Alterio, Rosa Anna Siciliano, Deborah Sementa, Stefano Tomassi, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli
We previously reported the discovery of a CXCL12-mimetic cyclic peptide (2) as a selective CXCR4 antagonist showing promising in vitro and in vivo anticancer activity. However, further development of this peptide was hampered by its degradation in biological fluids as well as by its low micromolar affinity for the receptor. Herein, extensive chemical modifications led to the development of a new analogue (10) with enhanced potency, specificity, and plasma stability. A combined approach of Ala-amino acid scan, NMR, and molecular modeling unraveled the reasons behind the improved binding properties of 10 vs 2...
September 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27521759/omeprazole-impairs-vascular-redox-biology-and-causes-xanthine-oxidoreductase-mediated-endothelial-dysfunction
#6
Lucas C Pinheiro, Gustavo H Oliveira-Paula, Rafael L Portella, Danielle A Guimarães, Celio D de Angelis, Jose E Tanus-Santos
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increased xanthine oxidoreductase (XOR) activity mediates PPIs-induced endothelial dysfunction (ED). We examined whether increased XOR activity impairs vascular redox biology and causes ED in rats treated with omeprazole...
August 4, 2016: Redox Biology
https://www.readbyqxmd.com/read/27508466/health-practices-the-view-of-the-black-elderly-population-in-a-terreiro-community
#7
Katia Peres Farias, Maria da Graça Oliveira Crossetti, Marta Georgina Oliveira de Góes, Vera Catarina Portella
OBJECTIVE: to understand health practices of black, elderly people in a terreiro community (community of followers of traditional African-Brazilian religions). METHOD: qualitative descriptive study under the Black-African paradigm of civilization constituted by the Black-African cultural complex and the structuring elements of the African cosmovision. Semi-structured interviews were carried out from July to September 2013, with six black older people from a terreiro community in Porto Alegre, RS...
July 2016: Revista Brasileira de Enfermagem
https://www.readbyqxmd.com/read/27476629/the-effects-of-the-pilates-method-in-the-elderly-a-systematic-review
#8
Patrícia Becker Engers, Airton José Rombaldi, Elisa Gouvêa Portella, Marcelo Cozzensa da Silva
Several studies show the benefits of including muscle strength and aerobic physical activity in the routine of elderly people. Among the various possibilities of physical activity, the Pilates method has become a popular modality in recent years, through a system of exercises enabling to work the whole body and that corrects posture and realigns the muscles, developing the body stability needed for a healthier life. The aim of this study was to review the current evidence on the effects of the practice of the Pilates method in the elderly...
July 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27475033/horses-seropositive-for-toxoplasma-gondii-sarcocystis-spp-and-neospora-spp-possible-risk-factors-for-infection-in-brazil
#9
Chrystian J Cazarotto, Alexandre Balzan, Rhayana K Grosskopf, Jhonatan P Boito, Luiza P Portella, Fernanda F Vogel, Juscivete F Fávero, Diego de C Cucco, Angelisa H Biazus, Gustavo Machado, Aleksandro S Da Silva
Many parasitic diseases are considered asymptomatic, even though some studies have shown that they may cause pathological changes in the host. Therefore, the aim of this study was to evaluate the occurrence of antibodies against Toxoplasma gondii, Neospora spp. and Sarcocystis spp. in horses, and to identify the risk factors for disease. For this, 174 horses were studied, 90 males and 84 females aged between two and 20 years old. Blood samples were collected and stored in tubes without anticoagulant to obtain serum, which was subjected to serological tests for T...
October 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27468829/ebola-virus-disease-and-critical-illness
#10
REVIEW
Aleksandra Leligdowicz, William A Fischer, Timothy M Uyeki, Thomas E Fletcher, Neill K J Adhikari, Gina Portella, Francois Lamontagne, Christophe Clement, Shevin T Jacob, Lewis Rubinson, Abel Vanderschuren, Jan Hajek, Srinivas Murthy, Mauricio Ferri, Ian Crozier, Elhadj Ibrahima, Marie-Claire Lamah, John S Schieffelin, David Brett-Major, Daniel G Bausch, Nikki Shindo, Adrienne K Chan, Tim O'Dempsey, Sharmistha Mishra, Michael Jacobs, Stuart Dickson, G Marshall Lyon, Robert A Fowler
As of 20 May 2016 there have been 28,646 cases and 11,323 deaths resulting from the West African Ebola virus disease (EVD) outbreak reported to the World Health Organization. There continue to be sporadic flare-ups of EVD cases in West Africa.EVD presentation is nonspecific and characterized initially by onset of fatigue, myalgias, arthralgias, headache, and fever; this is followed several days later by anorexia, nausea, vomiting, diarrhea, and abdominal pain. Anorexia and gastrointestinal losses lead to dehydration, electrolyte abnormalities, and metabolic acidosis, and, in some patients, acute kidney injury...
2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27426685/parasacral-transcutaneous-electrical-nerve-stimulation-for-overactive-bladder-in-constipated-children-the-role-of-constipation
#11
Maria Luiza Veiga, Elen Veruska Costa, Inaah Portella, Ananda Nacif, Ana Aparecida Martinelli Braga, Ubirajara Barroso
BACKGROUND: Parasacral transcutaneous electrical nerve stimulation (TENS) is an effective method for the treatment of overactive bladder (OAB), and, additionally, it accelerates bowel transit time. Therefore, not only does parasacral transcutaneous electrical nerve stimulation (TENS) improve lower urinary tract symptoms (LUTS), but it also resolves the problem of constipation in a significant number of children. Since TENS has a positive effect on LUTS and on the symptoms of fecal retention, it is possible that its action regarding OAB could be directly associated with the improvement in constipation...
July 5, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27283351/letter-to-the-editor-about-lost-data-in-cohort-studies
#12
R Quiroz-Portella, C Valer-Montoya, G F Alvarado
No abstract text is available yet for this article.
August 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27277233/dna-extraction-methods-and-multiple-sampling-to-improve-molecular-diagnosis-of-sarcocystis-spp-in-cattle-hearts
#13
Patrícia Bräunig, Luiza Pires Portella, Alfredo Skrebsky Cezar, Felipe Libardoni, Luis Antonio Sangioni, Fernanda Silveira Flores Vogel, Paulo Bayard Dias Gonçalves
Molecular detection of Sarcocystis spp. in tissue samples can be useful for experimental and diagnostic purposes. However, the parasite spreads unevenly through tissues, forming tissue cysts, and the cystic wall is an obstacle in DNA extraction protocols. Therefore, adequate sampling and effective disruption of the cysts are essential to improve the accuracy of DNA detection by PCR. The aims of this study were to evaluate the suitability of four protocols for DNA extraction from cysts of Sarcocystis spp. present in bovine myocardium samples or after their harvest in phosphate-buffered saline (PBS) solution as well as determine the effects of single or multiple sampling on the accuracy of molecular diagnosis of sarcocystosis in cattle hearts...
October 2016: Parasitology Research
https://www.readbyqxmd.com/read/27245810/benefits-of-a-secondary-prevention-program-in-suicide
#14
Adriana Farré, Maria J Portella, Luis De Angel, Ana Díaz, Javier de Diego-Adeliño, Joan Vegué, Santiago Duran-Sindreu, Gustavo Faus, Carmen Tejedor, Enric Álvarez, Víctor Pérez
BACKGROUND: The effectiveness of suicide intervention programs has not been assessed with experimental designs. AIM: To determine the risk of suicide reattempts in patients engaged in a secondary prevention program. METHOD: We included 154 patients with suicidal behavior in a quasi-experimental study with a nontreatment concurrent control group. In all, 77 patients with suicidal behavior underwent the Suicide Behavior Prevention Program (SBPP), which includes specialized early assistance during a period of 3-6 months...
June 1, 2016: Crisis
https://www.readbyqxmd.com/read/27159902/naturalistic-course-of-major-depressive-disorder-predicted-by-clinical-and-structural-neuroimaging-data-a-5-year-follow-up
#15
Maria Serra-Blasco, Javier de Diego-Adeliño, Yolanda Vives-Gilabert, Joan Trujols, Dolors Puigdemont, Mar Carceller-Sindreu, Victor Pérez, Enric Álvarez, Maria J Portella
BACKGROUND: Despite its high recurrence rate, major depression disorder (MDD) still lacks neurobiological markers to optimize treatment selection. The aim of this study was to examine the prognostic potential of clinical and structural magnetic resonance imaging (sMRI) in the long-term MDD clinical outcomes (COs). METHODS: Forty-nine MDD patients were grouped into one of four different CO categories according to their trajectory: recovery, partial remission, remission recurrence, and chronic depression...
May 9, 2016: Depression and Anxiety
https://www.readbyqxmd.com/read/27095565/fourth-generation-assays-for-hiv-testing
#16
Luca Vallefuoco, Claudia Mazzarella, Giuseppe Portella
INTRODUCTION: Laboratory diagnosis of HIV infection is essential for the prevention of infection and the identification of infected individuals who could benefit from highly active antiretroviral therapy. Since the release of the first assays for the detection of anti-HIV antibodies, the technology of immunoassays has improved. AREAS COVERED: Fourth generation assays - simultaneously detecting HIV p24 antigen and antibodies - have been developed and have been a major improvement in the detection of HIV infection, with a reduction of the diagnostic window...
July 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27054068/anthelmintic-resistance-in-gastrointestinal-nematodes-of-beef-cattle-in-the-state-of-rio-grande-do-sul-brazil
#17
Fernanda Ramos, Luiza Pires Portella, Fernando de Souza Rodrigues, Caroline Zamperete Reginato, Luciana Pötter, Alfredo Skrebsky Cezar, Luís Antônio Sangioni, Fernanda Silveira Flores Vogel
Gastrointestinal nematodes resistant to anthelmintics have been reported in several regions of Brazil, and they may be associated with economic losses for the cattle industry. This study aimed to evaluate the resistance status of gastrointestinal nematodes from naturally infected beef cattle to several commercially available anthelmintics, as well as to test the efficacy of combinations of anthelmintics against multi-resistant gastrointestinal nematodes. Ten farms located in Rio Grande do Sul state were selected by: farmers' consent; extensive raising system; availability of calves aged from 7 to 9 months naturally infected by gastrointestinal nematodes; absence of anthelmintic treatment for 60 days before the study; and presence of 70-100 calves or more of both genders with ≥ 200 eggs per gram of feces (EPG) (sensitivity of 50 EPG)...
April 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27021455/utility-of-panoramic-radiography-for-identification-of-the-pubertal-growth-period
#18
Luciana Jácome Lopes, Thiago de Oliveira Gamba, Maria Augusta Portella Guedes Visconti, Glaucia Maria Bovi Ambrosano, Francisco Haiter-Neto, Deborah Queiroz Freitas
INTRODUCTION: Our aim in this study was to investigate the association between dental mineralization stages and the periods of the pubertal growth spurt (PGS). METHODS: The sample included panoramic and hand-wrist radiographs from 491 subjects (222 boys, 269 girls) aged 7 to 17 years. Dental development was rated, and skeletal maturation was evaluated. The relevant associations were investigated by analysis of ordinal multinomial logistic regression. RESULTS: The second molar (odds ratio [OR] = 4...
April 2016: American Journal of Orthodontics and Dentofacial Orthopedics
https://www.readbyqxmd.com/read/27020846/the-effects-of-the-pilates-method-in-the-elderly-a-systematic-review
#19
Patrícia Becker Engers, Airton José Rombaldi, Elisa Gouvêa Portella, Marcelo Cozzensa da Silva
Several studies show the benefits of including muscle strength and aerobic physical activity in the routine of elderly people. Among the various possibilities of physical activity, the Pilates method has become a popular modality in recent years, through a system of exercises enabling to work the whole body and that corrects posture and realigns the muscles, developing the body stability needed for a healthier life. The aim of this study was to review the current evidence on the effects of the practice of the Pilates method in the elderly...
March 9, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/26986310/influence-of-the-aspect-ratio-and-boundary-conditions-on-universal-finite-size-scaling-functions-in-the-athermal-metastable-two-dimensional-random-field-ising-model
#20
Víctor Navas-Portella, Eduard Vives
This work studies universal finite size scaling functions for the number of one-dimensional spanning avalanches in a two-dimensional (2D) disordered system with boundary conditions of different nature and different aspect ratios. To this end, we will consider the 2D random field Ising model at T=0 driven by the external field H with athermal dynamics implemented with periodic and forced boundary conditions. We have chosen a convenient scaling variable z that accounts for the deformation of the distance to the critical point caused by the aspect ratio...
February 2016: Physical Review. E
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