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https://www.readbyqxmd.com/read/29770761/low-birth-weight-is-associated-with-increased-fat-intake-in-school-aged-boys
#1
Adrianne R Bischoff, André K Portella, Catherine Paquet, Roberta Dalle Molle, Aida Faber, Narendra Arora, Robert D Levitan, Patrícia P Silveira, Laurette Dube
Evidence suggests that both high and low birth weight children have increased the risk for obesity and the metabolic syndrome in adulthood. Previously we have found altered feeding behaviour and food preferences in pre-school children and adults born with low birth weight. In this study, we investigated if birth weight was associated with different intake of fat, carbohydrate and/or protein at 6-12 years of age. This is a cross-sectional study where 255 guardians answered online and telephone questions including anthropometrics and demographic data, parental family food rules (food control, encouragement and restriction) and a complete web-based FFQ for their children (130 boys and 125 girls)...
June 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29767906/use-of-crack-in-pregnancy-repercussions-for-the-newborn
#2
Daiani Modernel Xavier, Giovana Calcagno Gomes, Juliane Portella Ribeiro, Marina Soares Mota, Simone Quadros Alvarez
OBJECTIVES: To know the effects for the newborn of the use of crack in pregnancy. METHODS: This is a qualitative study conducted in a university hospital in southern Brazil, in the first half of 2014. Fifteen mothers crack users and five grandparents participated. The data were produced through semi-structured interviews and later submitted to content analysis. RESULTS: It was found that the use of crack in pregnancy leads to repercussions related to the health of the newborn and repercussions related to family restructuring...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29731661/electrophysiologic-alterations-in-the-excitability-of-the-sciatic-and-vagus-nerves-during-early-stages-of-sepsis
#3
Lúcio Ricardo Leite Diniz, Viviane Gomes Portella, Kerly Shamira da Silva Alves, Pâmella Cristina da Costa Araújo, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Aline Alice Cavalcante de Albuquerque, Andrelina Noronha Coelho-de-Souza, José Henrique Leal-Cardoso
Background: Nonspecific and delayed diagnosis of neurologic damage contributes to the development of neuropathies in patients with severe sepsis. The present study assessed the electrophysiologic parameters related to the excitability and conductibility of sciatic and vagus nerves during early stages of sepsis. Materials and methods: Twenty-four hours after sepsis induced by cecal ligation and puncture (CLP) model, sciatic and vagus nerves of septic (CLP group) and control (sham group) rats were removed, and selected electric stimulations were applied to measure the parameters of the first and second components of the compound action potential...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29713527/characterization-of-the-catalytic-structure-of-plant-phytase-protein-tyrosine-phosphatase-like-phytase-and-histidine-acid-phytases-and-their-biotechnological-applications
#4
REVIEW
Alex Sander Rodrigues Cangussu, Deborah Aires Almeida, Raimundo Wagner de Souza Aguiar, Sidnei Emilio Bordignon-Junior, Kelvinson Fernandes Viana, Luiz Carlos Bertucci Barbosa, Edson Wagner da Silva Cangussu, Igor Viana Brandi, Augustus Caeser Franke Portella, Gil Rodrigues Dos Santos, Eliane Macedo Sobrinho, William James Nogueira Lima
Phytase plays a prominent role in monogastric animal nutrition due to its ability to improve phytic acid digestion in the gastrointestinal tract, releasing phosphorus and other micronutrients that are important for animal development. Moreover, phytase decreases the amounts of phytic acid and phosphate excreted in feces. Bioinformatics approaches can contribute to the understanding of the catalytic structure of phytase. Analysis of the catalytic structure can reveal enzymatic stability and the polarization and hydrophobicity of amino acids...
2018: Enzyme Research
https://www.readbyqxmd.com/read/29595110/coumarin-compounds-in-medicinal-chemistry-some-important-examples-from-the-last-year
#5
Arthur Eugen Kummerle, Felipe Vitorio, Daiana Portella Franco, Thiago Moreira Pereira
Coumarins are natural products characterized as 1,2 benzopirones widely distributed in plants, as well as, in many species of fungi and bacteria. Nowadays, many synthetic procedures allow the discovery of coumarins with expanded chemical space. The ability to exert noncovalent interactions with many enzymes and receptors in live organisms lead the coumarins to exhibit a wide range of biological activities and applications. Then, this manuscript provides an overview of the use of coumarins compounds in Medicinal Chemistry in treating many diseases...
March 28, 2018: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29548208/increasing-power-law-range-in-avalanche-amplitude-and-energy-distributions
#6
Víctor Navas-Portella, Isabel Serra, Álvaro Corral, Eduard Vives
Power-law-type probability density functions spanning several orders of magnitude are found for different avalanche properties. We propose a methodology to overcome empirical constraints that limit the range of truncated power-law distributions. By considering catalogs of events that cover different observation windows, the maximum likelihood estimation of a global power-law exponent is computed. This methodology is applied to amplitude and energy distributions of acoustic emission avalanches in failure-under-compression experiments of a nanoporous silica glass, finding in some cases global exponents in an unprecedented broad range: 4...
February 2018: Physical Review. E
https://www.readbyqxmd.com/read/29522685/ligand-based-nmr-study-of-c-x-c-chemokine-receptor-type-4-cxcr4-ligand-interactions-on-living-cancer-cells
#7
Diego Brancaccio, Donatella Diana, Salvatore Di Maro, Francesco Saverio Di Leva, Stefano Tomassi, Roberto Fattorusso, Luigi Russo, Stefania Scala, Anna Maria Trotta, Luigi Portella, Ettore Novellino, Luciana Marinelli, Alfonso Carotenuto
Peptide-binding G protein-coupled receptors (GPCRs) are key effectors in numerous pathological and physiological pathways. The assessment of the receptor-bound conformation of a peptidic ligand within a membrane receptor such as a GPCR is of great impact for a rational drug design of more potent analogues. In this work, we applied multiple ligand-based nuclear magnetic resonance (NMR) methods to study the interaction of peptide heptamers, derived from the C-X-C Motif Chemokine 12 (CXCL12), and the C-X-C Chemokine Receptor Type 4 (CXCR4) on membranes of human T-Leukemia cells (CCRF-CEM cells)...
April 12, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29489449/hepatoprotective-effect-of-essential-oils-from-hyptis-crenata-in-sepsis-induced-liver-dysfunction
#8
Glauber Cruz Lima, Yuri de Abreu Gomes Vasconcelos, Marilia Trindade de Santana Souza, Alan Santos Oliveira, Rangel Rodrigues Bomfim, Ricardo Luiz Cavalcanti de Albuquerque Júnior, Enilton Aparecido Camargo, Viviane Gomes Portella, Andrelina Noronha Coelho-de-Souza, Lúcio Ricardo Leite Diniz
No specific therapeutics are available for the treatment of sepsis-induced liver dysfunction, a clinical complication strongly associated with the high mortality rate of septic patients. This study investigated the effect of the essential oil of Hyptis crenata (EOHc), a lamiaceae plant used to treat liver disturbances in Brazilian folk medicine, on liver function during early sepsis. Sepsis was induced by the cecal ligation and puncture (CLP) model. Rats were divided into four groups: Sham, Sham+EOHc, CLP, and CLP+EOHc...
February 28, 2018: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29482974/cognitive-predictors-of-illness-course-at-12-months-after-first-episode-of-depression
#9
M Vicent-Gil, A Keymer-Gausset, M Serra-Blasco, M Carceller-Sindreu, J de Diego-Adeliño, J Trujols, M Mur, V Pérez, E Alvarez, N Cardoner, M J Portella
Major Depressive Disorder (MDD) entails cognitive dysfunction in many cognitive domains, but it is still uncertain whether such deficits are present in the early stages. The purpose of the study is to determine the cognitive performance in first episode depression (FED) exploring the presence of different cognitive profiles, and the role of cognition in FED at baseline and long-term. Ninety subjects (18-50 years) were included, 50 patients with a FED and 40 healthy controls. Participants were assessed with a neuropsychological battery, covering language, attention, verbal memory, processing speed and executive domains...
April 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29476803/water-based-aerobic-and-combined-training-in-elderly-women-effects-on-functional-capacity-and-quality-of-life
#10
Mariana Ribeiro Silva, Cristine Lima Alberton, Elisa Gouvêa Portella, Gabriela Neves Nunes, Daniela Gomez Martin, Stephanie Santana Pinto
This study aimed to investigate the effects of two water-based training programs (aerobic and combined) and a non-periodized physical activity program on functional capacity and quality of life (QoL) of elderly women. Forty-one elderly female volunteers (65 ± 4 years) were divided into three groups: aerobic training group (WBA, n = 13), combined training (sequence: resistance/aerobic; WBC; n = 11) and a control group of non-periodized physical activity program (CG, n = 9). The participants performed the water-based trainings twice a week for 12 weeks...
June 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29475640/geochemical-behavior-environmental-availability-and-reconstruction-of-historical-trends-of-cu-pb-and-zn-in-sediment-cores-of-the-canan%C3%A3-ia-iguape-coastal-system-southeastern-brazil
#11
Keila Modesto Tramonte, Rubens Cesar Lopes Figueira, Alessandra Pereira Majer, Paulo Alves de Lima Ferreira, Miriam Fernanda Batista, Andreza Portella Ribeiro, Michel Michaelovitch de Mahiques
The Cananéia-Iguape system is located in a coastal region of southeastern Brazil, recognized by UNESCO as an Atlantic Forest Biosphere Reserve. This system has suffered substantial environmental impacts due to the opening of an artificial channel and by past intensive mining activities. In this paper was performed the sequential chemical extraction of Cu, Pb, and Zn, on previously described sediment cores, and the statistical treatment of the data, allowing to estimate the remobilization geochemical behavior, the available content and the trend of accumulation between 1926 and 2008...
February 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29448319/crossover-from-three-dimensional-to-two-dimensional-systems-in-the-nonequilibrium-zero-temperature-random-field-ising-model
#12
Djordje Spasojević, Svetislav Mijatović, Víctor Navas-Portella, Eduard Vives
We present extensive numerical studies of the crossover from three-dimensional to two-dimensional systems in the nonequilibrium zero-temperature random-field Ising model with metastable dynamics. Bivariate finite-size scaling hypotheses are presented for systems with sizes L×L×l which explain the size-driven critical crossover from two dimensions (l=const, L→∞) to three dimensions (l∝L→∞). A model of effective critical disorder R_{c}^{eff}(l,L) with a unique fitting parameter and no free parameters in the R_{c}^{eff}(l,L→∞) limit is proposed, together with expressions for the scaling of avalanche distributions bringing important implications for related experimental data analysis, especially in the case of thin three-dimensional systems...
January 2018: Physical Review. E
https://www.readbyqxmd.com/read/29397095/research-methods-in-complementary-and-alternative-medicine-an-integrative-review
#13
REVIEW
Fabiana de Almeida Andrade, Caio Fabio Schlechta Portella
The scientific literature presents a modest amount of evidence in the use of complementary and alternative medicine (CAM). On the other hand, in practice, relevant results are common. The debates among CAM practitioners about the quality and execution of scientific research are important. Therefore, the aim of this review is to gather, synthesize and describe the differentiated methodological models that encompass the complexity of therapeutic interventions. The process of bringing evidence-based medicine into clinical practice in CAM is essential for the growth and strengthening of complementary medicines worldwide...
January 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29358043/impact-of-acute-kidney-injury-on-short-and-long-term-outcomes-after-transcatheter-aortic-valve-implantation
#14
Antonio C B Nunes Filho, Marcelo Katz, Carlos M Campos, Luiz A Carvalho, Dimytri A Siqueira, Rogério T Tumelero, Antenor L F Portella, Vinícius Esteves, Marco A Perin, Rogério Sarmento-Leite, Pedro A Lemos Neto, Flavio Tarasoutchi, Hiram G Bezerra, Fábio S de Brito
INTRODUCTION AND OBJECTIVES: Acute kidney injury (AKI) is frequently observed after transcatheter aortic valve implantation (TAVI) and is associated with higher mortality. However, the impact of AKI on long-term outcomes remains controversial. Therefore, we sought to evaluate the impact of AKI on short- and long-term outcomes following TAVI using the Valve Academic Research Consortium 2 criteria. METHODS: Consecutive patients (n = 794) with severe aortic stenosis who underwent TAVI were included in a multicenter Brazilian registry...
January 18, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29338891/gray-and-white-matter-changes-and-their-relation-to-illness-trajectory-in-first-episode-psychosis
#15
Alejandro Keymer-Gausset, Anna Alonso-Solís, Iluminada Corripio, Rosa B Sauras-Quetcuti, Edith Pomarol-Clotet, Erick J Canales-Rodriguez, Eva Grasa-Bello, Enric Álvarez, Maria J Portella
Previous works have studied structural brain characteristics in first-episode psychosis (FEP), but few have focused on the relation between brain differences and illness trajectories. The aim of this study is to analyze gray and white matter changes in FEP patients and their relation with one-year clinical outcomes. A sample of 41 FEP patients and 41 healthy controls (HC), matched by age and educational level was scanned with a 3T MRI during the first month of illness onset. One year later, patients were assigned to two illness trajectories (schizophrenia and non-schizophrenia)...
March 2018: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29331244/perception-of-faunal-circadian-rhythms-depends-on-sampling-technique
#16
Raül Triay-Portella, Aitor Escribano, José G Pajuelo, Fernando Tuya
Ecologists aim at disentangling how species vary in abundance through spatial and temporal scales, using a range of sampling techniques. Here, we investigated the circadian rhythm of seagrass-associated decapod crustaceans through three sampling techniques. Specifically, we compared the abundance, biomass and structure of seagrass-associated decapod assemblages between the day and night using a hand net, an airlift pump and baited traps. At night, the hand-net consistently collected a larger total abundance and biomass of decapods, what resulted in significant diel differences, which were detected for the total biomass, but not for the total abundance, when decapods were sampled through an airlift pump...
March 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29287192/multiple-mechanistic-action-of-rosmarinus-officinalis-l-extract-against-ethanol-effects-in-an-acute-model-of-intestinal-damage
#17
Guilherme Pires Amaral, Fernando Dobrachinski, Nelson Rodrigues de Carvalho, Rômulo Pillon Barcelos, Michele Hinerasky da Silva, Thiago Henrique Lugokenski, Glaecir Roseni Mundstock Dias, Rafael de Lima Portella, Roselei Fachinetto, Félix Alexandre Antunes Soares
The high levels of oxidative stress and inflammation can be present in the etiology of degenerative intestinal pathologies associated with ethanol ingestion. The Rosmarinus officinalis L. has exhibited several physiological and medicinal activities. In this investigation, we intended to clarify, for the first time, the antioxidant and anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. (eeRo) against an acute damage induced by ethanol, specifically in the small intestine of rats. The rats were treated three times, at every 24 h, with eeRo at 500-1000 mg/kg or vehicle, oral gavage...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29241762/eltrombopag-for-advanced-myelodysplastic-syndromes-or-acute-myeloid-leukaemia-and-severe-thrombocytopenia-aspire-a-randomised-placebo-controlled-phase-2-trial
#18
Moshe Mittelman, Uwe Platzbecker, Boris Afanasyev, Sebastian Grosicki, Raymond S M Wong, Achilles Anagnostopoulos, Benjamin Brenner, Claudio Denzlinger, Giuseppe Rossi, Arnon Nagler, Regina Garcia-Delgado, Maria Socorro O Portella, Zewen Zhu, Dominik Selleslag
BACKGROUND: Thrombocytopenia is a life-threatening complication in patients with advanced myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). In this study (ASPIRE), we aimed to assess eltrombopag, an oral thrombopoietin receptor agonist, for thrombocytopenia (grade 4) treatment in adult patients with advanced MDS or AML. METHODS: ASPIRE consisted of an open-label, double-blind phase for 8 weeks and a randomised, double-blind phase (parts 1 and 2, reported here) for 12 weeks, and an open-label extension (part 3)...
January 2018: Lancet Haematology
https://www.readbyqxmd.com/read/29125295/structure-activity-relationships-and-biological-characterization-of-a-novel-potent-and-serum-stable-c-x-c-chemokine-receptor-type-4-cxcr4-antagonist
#19
Salvatore Di Maro, Francesco Saverio Di Leva, Anna Maria Trotta, Diego Brancaccio, Luigi Portella, Michela Aurilio, Stefano Tomassi, Anna Messere, Deborah Sementa, Secondo Lastoria, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli
In our ongoing pursuit of CXCR4 antagonists as potential anticancer agents, we recently developed a potent, selective and plasma stable peptide, Ac-Arg-Ala-[D-Cys-Arg-Phe-Phe-Cys]-COOH (3). Nevertheless, this compound was still not enough potent (IC50 ≈ 53 nM) to enter preclinical studies. Thus, a lead-optimization campaign was here undertaken to further improve the binding affinity of 3 while preserving its selectivity and proteolytic stability. Specifically, extensive structure-activity relationships (SARs) investigations were carried out on both its aromatic and disulfide forming amino acids...
November 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29120571/a-healthy-hla-matched-baby-born-by-using-a-combination-of-acgh-and-karyomapping-the-first-latin-american-case
#20
Andrea Delgado, Guillermo Llerena, Rosmary Lopez, Jimmy Portella, Naomi Inoue, Luis Noriega-Hoces, Luis Guzman
PGD for HLA typing is a procedure that can be performed when an affected child requires a transplant to treat a non-hereditary disorder related to the hematopoietic and/or immune system. Hematopoietic stem cell transplantation from an HLA-identical donor provides the best treatment option. Three conventional ovarian stimulation procedures for IVF were performed in a couple with a 10-year-old child diagnosed with T-cell acute lymphoblastic leukemia of high risk. Trophectoderm biopsy and aCGH examination were performed on 15 blastocysts, three on the first IVF procedure, four on the second cycle, and eight on the third...
December 1, 2017: JBRA Assisted Reproduction
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