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https://www.readbyqxmd.com/read/28431955/the-course-of-modic-vertebral-body-changes-after-posterolateral-lumbar-fusion-on-fused-and-adjacent-levels-a-systematic-review-of-the-literature
#1
REVIEW
Stella Taylor Portella, Marcus André Acioly
According to the original description by Modic et al., the natural course of bone marrow signal abnormalities is an inexorable, progressive one, however recent evidence has demonstrated in healthy individuals and those suffering from lumbar disc herniation that the course of endplate degenerative changes is rather dynamic and sometimes regressive. The evolution of such changes in lumbar fused segments and adjacent levels is largely unknown. The literature relevant to the course of Modic changes on fused and adjacent levels, as well as its clinical correspondence in patients undergoing posterolateral lumbar fusion was collected...
April 18, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28424961/tillandsia-usneoides-a-successful-alternative-for-biomonitoring-changes-in-air-quality-due-to-a-new-highway-in-s%C3%A3-o-paulo-brazil
#2
EDITORIAL
Poliana Cardoso-Gustavson, Francine Faia Fernandes, Edenise Segala Alves, Mariana Pereira Victorio, Barbara Baesso Moura, Marisa Domingos, Caroline Albuquerque Rodrigues, Andreza Portella Ribeiro, Catarina Carvalho Nievola, Ana Maria G Figueiredo
No abstract text is available yet for this article.
May 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28406400/the-rnf168-paralog-rnf169-defines-a-new-class-of-ubiquitylated-histone-reader-involved-in-the-response-to-dna-damage
#3
Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay
Site-specific histone ubiquitylation plays a central role in orchestrating the response to DNA double-strand breaks (DSBs). DSBs elicit a cascade of events controlled by the ubiquitin ligase RNF168, which promotes the accumulation of repair factors such as 53BP1 and BRCA1 on the chromatin flanking the break site. RNF168 also promotes its own accumulation, and that of its paralog RNF169, but how they recognize ubiquitylated chromatin is unknown. Using methyl-TROSY solution NMR spectroscopy and molecular dynamics simulations, we present an atomic resolution model of human RNF169 binding to a ubiquitylated nucleosome, and validate it by electron cryomicroscopy...
April 13, 2017: ELife
https://www.readbyqxmd.com/read/28341671/lipopolysaccharide-elicited-tslpr-expression-enriches-a-functionally-discrete-subset-of-human-cd14-cd1c-monocytes
#4
Francesco Borriello, Raffaella Iannone, Sarah Di Somma, Viviana Vastolo, Giuseppe Petrosino, Feliciano Visconte, Maddalena Raia, Giulia Scalia, Stefania Loffredo, Gilda Varricchi, Maria Rosaria Galdiero, Francescopaolo Granata, Luigi Del Vecchio, Giuseppe Portella, Gianni Marone
Thymic stromal lymphopoietin (TSLP) is a cytokine produced mainly by epithelial cells in response to inflammatory or microbial stimuli and binds to the TSLP receptor (TSLPR) complex, a heterodimer composed of TSLPR and IL-7 receptor α (CD127). TSLP activates multiple immune cell subsets expressing the TSLPR complex and plays a role in several models of disease. Although human monocytes express TSLPR and CD127 mRNAs in response to the TLR4 agonist LPS, their responsiveness to TSLP is poorly defined. We demonstrate that TSLP enhances human CD14(+) monocyte CCL17 production in response to LPS and IL-4...
May 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28327879/antibodies-against-apicomplexa-protozoa-and-absence-sarcocysts-in-heart-tissues-from-horses-in-southern-brazil
#5
Luiza Pires Portella, Gustavo Cauduro Cadore, Luis Antonio Sangioni, Luiz Fernando Vilani Pellegrini, Rafael Fighera, Fernanda Ramos, Fernanda Silveira Flores Vogel
Sarcocystis spp., Neospora spp., and Toxoplasma gondii are Apicomplexa protozoa that can infect horses. This study aimed to investigate the occurrence of antibodies against Sarcocystis spp., Neospora spp., and T. gondii in horses slaughtered in southern Brazil. The presence of histological lesions, tissue cysts, and Sarcocystis spp. DNA in the hearts of these horses was also investigated. A total of 197 paired serum and heart samples were evaluated by serology and direct microscopic examination; 50 of these samples were subjected to histopathological and PCR analyses...
January 2017: Revista Brasileira de Parasitologia Veterinária, Brazilian Journal of Veterinary Parasitology
https://www.readbyqxmd.com/read/28285190/nitrate-decreases-xanthine-oxidoreductase-mediated-nitrite-reductase-activity-and-attenuates-vascular-and-blood-pressure-responses-to-nitrite
#6
Célio Damacena-Angelis, Gustavo H Oliveira-Paula, Lucas C Pinheiro, Eduardo J Crevelin, Rafael L Portella, Luiz Alberto B Moraes, Jose E Tanus-Santos
Nitrite and nitrate restore deficient endogenous nitric oxide (NO) production as they are converted back to NO, and therefore complement the classic enzymatic NO synthesis. Circulating nitrate and nitrite must cross membrane barriers to produce their effects and increased nitrate concentrations may attenuate the nitrite influx into cells, decreasing NO generation from nitrite. Moreover, xanthine oxidoreductase (XOR) mediates NO formation from nitrite and nitrate. However, no study has examined whether nitrate attenuates XOR-mediated NO generation from nitrite...
March 6, 2017: Redox Biology
https://www.readbyqxmd.com/read/28278509/evaluation-of-the-automated-qiasymphony-sp-as-workflow-for-cytomegalovirus-dna-extraction-and-amplification-from-dried-blood-spots
#7
Daniela Spalletti-Cernia, Sara Barbato, Rosanna Sorrentino, Luca Vallefuoco, Caterina Rocco, Pasquale Di Costanzo, Antonella Giannattasio, Francesco Raimondi, Claudia Mazzarella, Roberta De Mattia, Giuseppe Portella
OBJECTIVE: Human cytomegalovirus (CMV) can be considered the most important agent of congenital infection. Long-term sequelae of congenital infection occur in about 15% of infants asymptomatic at birth. To avoid long-term sequelae or to reduce their burden, it is necessary to identify infected children for early interventions. CMV DNA can be detected in dried blood spots (DBSs). DBSs have been used in several studies for the retrospective diagnosis of congenital CMV (CCMV). It has been proposed to use DBSs for the newborn screening of CMV infection; however, manual methods are not suitable for newborn screening of CCMV...
2016: Intervirology
https://www.readbyqxmd.com/read/28260618/air-contaminants-and-litter-fall-decomposition-in-urban-forest-areas-the-case-of-s%C3%A3-o-paulo-sp-brazil
#8
Maurício Lamano Ferreira, Andreza Portella Ribeiro, Caroline Rodrigues Albuquerque, Ana Paula do Nascimento Lamano Ferreira, Rubens César Lopes Figueira, Raffaele Lafortezza
BACKGROUND: Urban forests are usually affected by several types of atmospheric contaminants and by abnormal variations in weather conditions, thus facilitating the biotic homogenization and modification of ecosystem processes, such as nutrient cycling. Peri-urban forests and even natural forests that surround metropolitan areas are also subject to anthropogenic effects generated by cities, which may compromise the dynamics of these ecosystems. Hence, this study advances the hypothesis that the forests located at the margins of the Metropolitan Region of São Paulo (MRSP), Brazil, have high concentrations of atmospheric contaminants leading to adverse effects on litter fall stock...
May 2017: Environmental Research
https://www.readbyqxmd.com/read/28251705/selenium-supplementation-modulates-apoptotic-processes-in-thyroid-follicular-cells
#9
Immacolata C Nettore, Emma De Nisco, Silvio Desiderio, Carmela Passaro, Luigi Maione, Mariarosaria Negri, Luigi Albano, Rosario Pivonello, Claudia Pivonello, Giuseppe Portella, Paola Ungaro, Annamaria Colao, Paolo E Macchia
Selenium (Se) is an essential micronutrient modulating several physiopathological processes in the human body. The aim of the study is to characterize the molecular effects determined by Se-supplementation in thyroid follicular cells, using as model the well-differentiated rat thyroid follicular cell line FRTL5. Experiments have been performed to evaluate the effects of Se on cell growth, mortality and proliferation and on modulation of pro- and antiapoptotic pathways. The results indicate that Se-supplementation improves FRTL5 growth rate...
March 2, 2017: BioFactors
https://www.readbyqxmd.com/read/28139359/altered-amplitude-of-low-frequency-fluctuations-in-schizophrenia-patients-with-persistent-auditory-verbal-hallucinations
#10
Anna Alonso-Solís, Yolanda Vives-Gilabert, Maria J Portella, Mireia Rabella, Eva M Grasa, Alexandra Roldán, Alejandro Keymer-Gausset, Conrad Molins, Fidel Núñez-Marín, Beatriz Gómez-Ansón, Enric Alvarez, Iluminada Corripio
The aim of this study is to analyze the differences in low frequency fluctuation (LFF) values between schizophrenia patients with and without auditory verbal hallucinations (AVH). Nineteen schizophrenia patients with persistent AVH (HP), fourteen non-hallucinating schizophrenia patients (nHP) and twenty healthy controls (HC) underwent R-fMRI. LFF values were calculated in the slow frequency band (0.01-0.08Hz). By means of group level contrasts, we performed direct voxel-wise group comparisons. Both groups of patients showed decreased amplitude LFF (ALFF) values in the occipital pole and lingual gyrus compared to HC, whereas increased ALFF values were found in the temporal pole and fusifom gyrus...
January 28, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28116499/lack-of-relationship-between-plasma-levels-of-escitalopram-and-qtc-interval-length
#11
Mar Carceller-Sindreu, Javier de Diego-Adeliño, Maria J Portella, Xavier Garcia-Moll, Maria Figueras, Aina Fernandez-Vidal, Josep M Queraltó, Dolors Puigdemont, Enric Álvarez
Despite safety concerns raised by the European Medicines Agency (EMA), evidence supporting QT-lengthening effects of escitalopram is far to be conclusive. We aimed to evaluate the relationship between escitalopram plasma levels (Escit-PL) and corrected QT-interval length (QTc-length) in 91 outpatients recruited from a hospital setting. Fifteen patients had an abnormally prolonged QTc-interval, and 3 had QTc-intervals ≥500 ms. No correlation between Escit-PL and QTc-length was found (r = 0.08; p = 0.45)...
January 23, 2017: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/28088759/how-accurate-are-accurate-force-fields-for-b-dna
#12
Pablo D Dans, Ivan Ivani, Adam Hospital, Guillem Portella, Carlos González, Modesto Orozco
Last generation of force-fields are raising expectations on the quality of molecular dynamics (MD) simulations of DNA, as well as to the belief that theoretical models can substitute experimental ones in several cases. However these claims are based on limited benchmarks, where MD simulations have shown the ability to reproduce already existing 'experimental models', which in turn, have an unclear accuracy to represent DNA conformation in solution. In this work we explore the ability of different force-fields to predict the structure of two new B-DNA dodecamers, determined herein by means of 1H nuclear magnetic resonance (NMR)...
April 20, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28077217/corrigendum-to-assessing-decentering-validation-psychometric-properties-and-clinical-usefulness-of-the-experiences-questionnaire-in-a-spanish-sample-behavior-therapy-45-2014-863-871
#13
Joaquim Soler, Alba Franquesa, Albert Feliu-Soler, Ausias Cebolla, Javier García-Campayo, Rosa Tejedor, Marcelo Demarzo, Rosa Baños, Juan Carlos Pascual, Maria J Portella
No abstract text is available yet for this article.
January 2017: Behavior Therapy
https://www.readbyqxmd.com/read/27992028/measurement-of-the-area-of-venous-ulcers-using-two-software-programs
#14
Thaís Dresch Eberhardt, Suzinara Beatriz Soares de Lima, Luis Felipe Dias Lopes, Eline de Lima Borges, Teresinha Heck Weiller, Graziele Gorete Portella da Fonseca
Objective: to compare the measurement area of venous ulcers using AutoCAD(r) and Image Tool software. Method: this was an assessment of reproducibility tests conducted in a angiology clinic of a university hospital. Data were collected from 21 patients with venous ulcers, in the period from March to July of 2015, using a collection form and photograph of wounds. Five nurses (evaluators) of the hospital skin wound study group participated. The wounds were measured using both software programs...
December 19, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27769921/oral-nitrite-circumvents-antiseptic-mouthwash-induced-disruption-of-enterosalivary-circuit-of-nitrate-and-promotes-nitrosation-and-blood-pressure-lowering-effect
#15
Lucas C Pinheiro, Graziele C Ferreira, Jefferson H Amaral, Rafael L Portella, Sandra de O C Tella, Madla A Passos, Jose E Tanus-Santos
The nitric oxide (NO(•)) metabolites nitrite and nitrate exert antihypertensive effects by mechanisms that involve gastric formation of S-nitrosothiols. However, while the use of antiseptic mouthwash (AM) is known to attenuate the responses to nitrate by disrupting its enterosalivary cycle, there is little information about whether AM attenuates the effects of orally administered nitrite. We hypothesized that the antihypertensive effects of orally administered nitrite would not be prevented by AM because, in contrast to oral nitrate, oral nitrite could promote S-nitrosothiols formation in the stomach without intereference by AM...
December 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27739796/avalanches-and-force-drops-in-displacement-driven-compression-of-porous-glasses
#16
Víctor Navas-Portella, Álvaro Corral, Eduard Vives
Similarities between force-driven compression experiments of porous materials and earthquakes have been recently proposed. In this paper, we measure the acoustic emission during displacement-driven compression of a porous glass. The energy of acoustic-emission events shows that the failure process exhibits avalanche scale-invariance and therefore follows the Gutenberg-Richter law. The resulting exponents do not exhibit significant differences with respect the force-driven case. Furthermore, the force exhibits an avalanche-type behavior for which the force drops are power-law distributed and correlated with the acoustic emission events...
September 2016: Physical Review. E
https://www.readbyqxmd.com/read/27730634/eco-morphological-attributes-and-feeding-habits-in-coexisting-characins
#17
T Portella, J Lobón-Cerviá, L R Manna, H G Bergallo, R Mazzoni
The head morphology and feeding habits of pairs of characin species (family Characidae) that coexist in four different coastal rainforest streams were analysed. Coexisting species differed in size, but were very similar in eco-morphological attributes. Gut analyses revealed differences in feeding preferences for each coexisting species, indicating resource partitioning. A pattern of organization in species pairs that was repeated in the four studied streams was noticed. The pattern consisted of one slightly larger species with a feeding preference for items of allochthonous origin and another smaller species with a preference for autochthonous items...
January 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/27592139/a-preliminary-longitudinal-study-on-the-cognitive-and-functional-outcome-of-bipolar-excellent-lithium-responders
#18
E Mora, M J Portella, I Forcada, E Vieta, M Mur
BACKGROUND: Neurocognitive dysfunction in bipolar disorder represents a possible marker of underlying pathophysiology, but to date, most studies are cross-sectional and heterogeneous with regard to pharmacological treatments. In the present study we investigated the 6-year cognitive and functional outcome of a sample of euthymic excellent lithium responders (ELR). METHOD: A total sample of twenty subjects was assessed at baseline and 6years later: ten diagnosed of bipolar disorder according to DSM-IV criteria and ten healthy matched controls...
July 30, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27571038/exploring-the-n-terminal-region-of-c-x-c-motif-chemokine-12-cxcl12-identification-of-plasma-stable-cyclic-peptides-as-novel-potent-c-x-c-chemokine-receptor-type-4-cxcr4-antagonists
#19
Salvatore Di Maro, Anna Maria Trotta, Diego Brancaccio, Francesco Saverio Di Leva, Valeria La Pietra, Caterina Ieranò, Maria Napolitano, Luigi Portella, Crescenzo D'Alterio, Rosa Anna Siciliano, Deborah Sementa, Stefano Tomassi, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli
We previously reported the discovery of a CXCL12-mimetic cyclic peptide (2) as a selective CXCR4 antagonist showing promising in vitro and in vivo anticancer activity. However, further development of this peptide was hampered by its degradation in biological fluids as well as by its low micromolar affinity for the receptor. Herein, extensive chemical modifications led to the development of a new analogue (10) with enhanced potency, specificity, and plasma stability. A combined approach of Ala-amino acid scan, NMR, and molecular modeling unraveled the reasons behind the improved binding properties of 10 vs 2...
September 22, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27521759/omeprazole-impairs-vascular-redox-biology-and-causes-xanthine-oxidoreductase-mediated-endothelial-dysfunction
#20
Lucas C Pinheiro, Gustavo H Oliveira-Paula, Rafael L Portella, Danielle A Guimarães, Celio D de Angelis, Jose E Tanus-Santos
Proton pump inhibitors (PPIs) are widely used drugs that may increase the cardiovascular risk by mechanisms not entirely known. While PPIs increase asymmetric dimethylarginine (ADMA) levels and inhibit nitric oxide production, it is unknown whether impaired vascular redox biology resulting of increased xanthine oxidoreductase (XOR) activity mediates PPIs-induced endothelial dysfunction (ED). We examined whether increased XOR activity impairs vascular redox biology and causes ED in rats treated with omeprazole...
August 4, 2016: Redox Biology
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