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https://www.readbyqxmd.com/read/29125295/structure-activity-relationships-and-biological-characterization-of-a-novel-potent-and-serum-stable-c-x-c-chemokine-receptor-type-4-cxcr4-antagonist
#1
Salvatore Di Maro, Francesco Saverio Di Leva, Anna Maria Trotta, Diego Brancaccio, Luigi Portella, Michela Aurilio, Stefano Tomassi, Anna Messere, Deborah Sementa, Secondo Lastoria, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli
In our ongoing pursuit of CXCR4 antagonists as potential anticancer agents, we recently developed a potent, selective and plasma stable peptide, Ac-Arg-Ala-[D-Cys-Arg-Phe-Phe-Cys]-COOH (3). Nevertheless, this compound was still not enough potent (IC50 ≈ 53 nM) to enter preclinical studies. Thus, a lead-optimization campaign was here undertaken to further improve the binding affinity of 3 while preserving its selectivity and proteolytic stability. Specifically, extensive structure-activity relationships (SARs) investigations were carried out on both its aromatic and disulfide forming amino acids...
November 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29120571/a-healthy-hla-matched-baby-born-by-using-a-combination-of-acgh-and-karyomapping-the-first-latin-american-case
#2
Andrea Delgado, Guillermo Llerena, Rosmary Lopez, Jimmy Portella, Naomi Inoue, Luis Noriega-Hoces, Luis Guzman
PGD for HLA typing is a procedure that can be performed when an affected child requires a transplant to treat a non-hereditary disorder related to the hematopoietic and/or immune system. Hematopoietic stem cell transplantation from an HLA-identical donor provides the best treatment option. Three conventional ovarian stimulation procedures for IVF were performed in a couple with a 10-year-old child diagnosed with T-cell acute lymphoblastic leukemia of high risk. Trophectoderm biopsy and aCGH examination were performed on 15 blastocysts, three on the first IVF procedure, four on the second cycle, and eight on the third...
November 9, 2017: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/29109422/periodic-squeezing-in-a-polariton-josephson-junction
#3
Albert F Adiyatullin, Mitchell D Anderson, Hugo Flayac, Marcia T Portella-Oberli, Fauzia Jabeen, Claudéric Ouellet-Plamondon, Gregory C Sallen, Benoit Deveaud
The use of a Kerr nonlinearity to generate squeezed light is a well-known way to surpass the quantum noise limit along a given field quadrature. Nevertheless, in the most common regime of weak nonlinearity, a single Kerr resonator is unable to provide the proper interrelation between the field amplitude and squeezing required to induce a sizable deviation from Poissonian statistics. We demonstrate experimentally that weakly coupled bosonic modes allow exploration of the interplay between squeezing and displacement, which can give rise to strong deviations from the Poissonian statistics...
November 6, 2017: Nature Communications
https://www.readbyqxmd.com/read/29069267/prevalence-of-household-falls-in-long-lived-adults-and-association-with-extrinsic-factors
#4
Silviane Galvan Pereira, Claudia Benedita Dos Santos, Marlene Doring, Marilene Rodrigues Portella
OBJECTIVE: to identify the prevalence of falls among older adults and the extrinsic factors associated with them. METHOD: population-based cross-sectional study with 350 older adults. A household survey was conducted using a questionnaire addressing socio-demographic, clinical, and environmental characteristics. Data were analyzed using Stata Software V.10. Pearson's chi-square test and logistic regression analysis were used with stepwise criteria for selection of variables in the model, with measures of effect expressed in Prevalence Ratio...
October 19, 2017: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/29062594/new-drugs-and-new-posterior-delivery-methods-in-cme
#5
João Rafael de Oliveira Dias, Renata Portella Nunes, Raquel Goldhardt
PURPOSE: To discuss the characteristics, indications and adverse events (AEs) of sustained-release corticosteroid devices for the treatment of cystoid macular edema (CME). RECENT FINDINGS: Ozurdex® is approved for the treatment of diabetic macular edema (DME), retinal vein occlusion related-CME and noninfectious posterior uveitis (NIPU). It releases dexamethasone over a maximum period of 6 months making repeated intravitreal injections necessary for recurrent CME...
June 2017: Current Ophthalmology Reports
https://www.readbyqxmd.com/read/29042367/safety-and-efficacy-of-long-term-treatment-of-chronic-persistent-itp-with-eltrombopag-final-results-of-the-extend-study
#6
Raymond S M Wong, Mansoor N Saleh, Abderrahim Khelif, Abdulgabar Salama, Maria Socorro O Portella, Paul Burgess, James B Bussel
In phase 2/3 trials, eltrombopag treatment for ≤6 months in patients with chronic/persistent immune thrombocytopenia (ITP) increased platelet counts and reduced bleeding. The open-label EXTEND study evaluated long-term safety and efficacy of eltrombopag in adults with ITP who had completed a previous eltrombopag study. For the 302 patients enrolled, median duration of eltrombopag treatment was 2.37 years (2 days to 8.76 years). Median platelet counts increased to ≥50×10(9)/L by week 2 and were sustained throughout the treatment period...
October 17, 2017: Blood
https://www.readbyqxmd.com/read/29024893/plasma-ratio-of-clozapine-to-n-desmethylclozapine-can-predict-cognitive-performance-in-treatment-resistant-psychotic-patients
#7
Conrad Molins, Mar Carceller-Sindreu, Helena Navarro, Cristina Carmona, Marina Piñeiro, Estrella Martínez, Enric Álvarez, Maria J Portella
Cognitive symptoms play a central role in schizophrenia and are strongly associated with social functioning. Treatment with clozapine presents controversial results regarding its effects on cognition. The opposite effects of clozapine and n-desmethylclozapine (NDMC) on cholinergic system have been suggested to underlie these inconclusive findings. The aim of this study is to determine whether clozapine/NDMC ratio can predict cognitive performance in patients with treatment-resistant psychosis. Nineteen clinically stable patients with schizophrenia or schizoaffective disorder treated with clozapine monotherapy completed demographic and clinical interviews...
December 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29020340/relationship-between-viremia-and-specific-organ-damage-in-ebola-patients-a-cohort-study
#8
Simone Lanini, Gina Portella, Francesco Vairo, Gary P Kobinger, Antonio Pesenti, Martin Langer, Soccoh Kabia, Giorgio Brogiato, Jackson Amone, Concetta Castilletti, Rossella Miccio, Maria Rosaria Capobianchi, Gino Strada, Alimuddin Zumla, Antonino Di Caro, Giuseppe Ippolito
Background: Pathogenesis of Ebola virus disease remains poorly understood. We used concomitant determination of routine laboratory biomarkers and Ebola viremia to explore the potential role of viral replication in specific organ damage. Methods: We recruited patients with detectable Ebola viremia admitted to the EMERGENCY ONG ONLUS Ebola Treatment Center in Sierra Leone. Repeated measure of Ebola viremia, ALT, AST, bilirubin, CPK, LDH, aPTT, INR, creatinine and BUN were recorded...
August 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28994517/the-impact-of-obesity-on-cognitive-functioning-in-euthymic-bipolar-patients-a-cross-sectional-and-longitudinal-study
#9
Ester Mora, Maria J Portella, Montserrat Martinez-Alonso, Montse Teres, Irene Forcada, Eduard Vieta, Maria Mur
OBJECTIVE: To determine the influence of body mass index (BMI) on cognition in euthymic bipolar patients and healthy matched controls in a post hoc study of 2 cross-sectional and longitudinal exploratory studies. METHOD: A total sample of 121 individuals was examined, which included 52 euthymic bipolar disorder I or II patients (DSM-IV-TR criteria) and 69 healthy controls matched by age and gender, categorized in 2 subgroups in terms of body mass index (BMI-factor): normal weight (BMI: 18...
October 3, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/28985218/spatial-and-temporal-trends-of-visceral-leishmaniasis-by-mesoregion-in-a-southeastern-state-of-brazil-2002-2013
#10
Thais Almeida Marques da Silva, Wendel Coura-Vital, David Soeiro Barbosa, Carla Sayuri Fogaça Oiko, Maria Helena Franco Morais, Bruna Dias Tourinho, Diogo Portella Ornelas de Melo, Ilka Afonso Reis, Mariângela Carneiro
BACKGROUND: Visceral leishmaniasis (VL) is expanding in Brazil and in other South American countries, a process that has been associated with the urbanization of the disease. This study analyzes the spatial and temporal distribution of VL in the Brazilian state of Minas Gerais and identifies the areas with higher risks of transmission. METHODOLOGY: An ecological study with spatial and time series analyzes of new confirmed cases of VL notified to the Brazilian Notifiable Disease Information System between 2002 and 2013, considering the 12 mesoregions of Minas Gerais...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28954158/-femicides-concepts-types-and-scenarios
#11
Stela Nazareth Meneghel, Ana Paula Portella
This text is a theoretical essay that discusses the concepts, types and scenarios of feminicides, and presents some proposals for the prevention of these premature, unjust and avoidable deaths. The text revisits the original concept of femicide proposed by Diana Russell and Jane Caputti and shows new and old scenarios where these crimes occur. It points to patriarchy, understood as being a hierarchical system of power between men and women, as one of the main determinants of these deaths. It ends by presenting actions and proposals to prevent and combat these gender crimes...
September 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28954065/guidelines-for-the-management-of-human-brucellosis-in-the-state-of-paran%C3%A3-brazil
#12
Felipe Francisco Tuon, Natacha Cerchiari, Juliana Clélia Cequinel, Elizabeth El Hajjar Droppa, Suzana Dal Ri Moreira, Tânia Portella Costa, Amanda de Paula Boni Navarro, Antonieta Milleo Handar, Margely Nunes de Souza
Human brucellosis is a re-emerging disease with the potential for bioterrorism. The number of cases in Brazil has increased; however, the ideal management has not been established. These guidelines are intended for use by clinicians and other health-care workers providing medical care for patients with suspected brucellosis in the State of Paraná. We included a brief description of the epidemiology, clinical presentation, diagnosis, prevention of exposure, prevention of disease by chemoprophylaxis, treatment of disease, monitoring of adverse effects during treatment, management of treatment failure and relapse cases...
July 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28914826/pulmonary-alveolar-proteinosis-a-case-report
#13
Luis Alberto Concepción-Urteaga, Luis Alejandro Rodríguez-Hidalgo, Jorge Luis Cornejo-Portella, Oscar Neri Alquizar-Horna, Daniel Anderson Aguilar-Villanueva, Marcio José Concepción-Zavaleta, Mario Gustavo Azañero-Luján
INTRODUCTION: Pulmonary alveolar proteinosis is a rare, diffuse interstitial lung disease, characterized by alveolar obstruction due to the accumulation of pulmonary surfactant. CLINICAL PRESENTATION: A 30-year-old male with progressively worsening dyspnea and non-productive cough for one year. He was a sugar cane plantation worker and had prior recurrent respiratory infections. Physical exam revealed cyanosis, and bilateral coarse and fine rales. Chest computed tomography showed diffuse crazy paving pattern...
September 14, 2017: Medwave
https://www.readbyqxmd.com/read/28854184/exploring-virulence-and-immunogenicity-in-the-emerging-pathogen-sporothrix-brasiliensis
#14
Paula Portella Della Terra, Anderson Messias Rodrigues, Geisa Ferreira Fernandes, Angela Satie Nishikaku, Eva Burger, Zoilo Pires de Camargo
Sporotrichosis is a polymorphic chronic infection of humans and animals classically acquired after traumatic inoculation with soil and plant material contaminated with Sporothrix spp. propagules. An alternative and successful route of transmission is bites and scratches from diseased cats, through which Sporothrix yeasts are inoculated into mammalian tissue. The development of a murine model of subcutaneous sporotrichosis mimicking the alternative route of transmission is essential to understanding disease pathogenesis and the development of novel therapeutic strategies...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28728089/volumetric-and-morphological-characteristics-of-the-hippocampus-are-associated-with-progression-to-schizophrenia-in-patients-with-first-episode-psychosis
#15
R Sauras, A Keymer, A Alonso-Solis, A Díaz, C Molins, F Nuñez, M Rabella, A Roldán, E Grasa, E Alvarez, M J Portella, I Corripio
BACKGROUND: Abnormalities in the hippocampus have been implicated in the pathophysiology of psychosis. However, it is still unclear whether certain abnormalities are a pre-existing vulnerability factor, a sign of disease progression or a consequence of environmental factors. We hypothesized that first-episode psychosis patients who progress to schizophrenia after one year of follow up will display greater volumetric and morphological changes from the very beginning of the disorder. METHODS: We studied the hippocampus of 41 patients with a first-episode psychosis and 41 matched healthy controls...
September 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28647786/mosaic-embryo-transfer-after-oocyte-in-vitro-maturation-in-combination-with-non-invasive-prenatal-testing-nipt-first-report-of-a-euploid%C3%A2-live-birth
#16
Naomi Inoue, Rosmary Lopez, Andrea Delgado, Denisse Nuñez, Jimmy Portella, Luis Noriega-Hoces, Luis Guzmán
PURPOSES: The purpose of this study is to describe a healthy life birth after a mosaic embryo transfer in oocyte in vitro maturation (IVM). METHODS: Patient received minimal stimulation, starting on day 3 after menstrual period. No hCG trigger was administered. Oocyte retrieval was performed and oocytes were matured for 30 h. After denuding, mature oocytes were inseminated by ICSI. Embryos were cultured until blastocyst stage and biopsied. RESULTS: One euploid embryo after array comprehensive genome hybridization (aCGH) was diagnostic...
September 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28644564/methacrylate-based-root-canal-sealer-containing-chlorexidine-and-%C3%AE-tricalcium-phosphate
#17
Fabrício Mezzomo Collares, Vicente Castelo Branco Leitune, Fernando Freitas Portella, Paula Dapper Santos, Gabriela de Souza Balbinot, Luís Alberto Dos Santos, Clarissa Cavalcanti Fatturi Parolo, Susana Maria Werner Samuel
The aim of this study was to develop and to characterize a methacrylate-based root canal sealer containing chlorhexidine (CHX) and α-tricalcium phosphate (α-TCP). Experimental dual cure methacrylate-based sealer was produced containing 0, 2.5, or 5 wt% of CHX and 0, 25, or 50 wt% of α-TCP. Experimental sealers were evaluated based on flow, film thickness, radiopacity, degree of conversion (DC), degradation in water, pH and antibacterial activity. Flow ranged from 15.09 ± 0.11 to 17.47 ± 0.42 mm...
June 23, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28632486/randomized-noncomparative-phase-ii-trial-of-early-switch-from-docetaxel-to-cabazitaxel-or-vice-versa-with-integrated-biomarker-analysis-in-men-with-chemotherapy-na%C3%A3-ve-metastatic-castration-resistant-prostate-cancer
#18
RANDOMIZED CONTROLLED TRIAL
Emmanuel S Antonarakis, Scott T Tagawa, Giuseppe Galletti, Daniel Worroll, Karla Ballman, Marie Vanhuyse, Guru Sonpavde, Scott North, Costantine Albany, Che-Kai Tsao, John Stewart, Atef Zaher, Ted Szatrowski, Wei Zhou, Ada Gjyrezi, Shinsuke Tasaki, Luigi Portella, Yang Bai, Timothy B Lannin, Shalu Suri, Conor N Gruber, Erica D Pratt, Brian J Kirby, Mario A Eisenberger, David M Nanus, Fred Saad, Paraskevi Giannakakou
Purpose The TAXYNERGY trial ( ClinicalTrials.gov identifier: NCT01718353) evaluated clinical benefit from early taxane switch and circulating tumor cell (CTC) biomarkers to interrogate mechanisms of sensitivity or resistance to taxanes in men with chemotherapy-naïve, metastatic, castration-resistant prostate cancer. Patients and Methods Patients were randomly assigned 2:1 to docetaxel or cabazitaxel. Men who did not achieve ≥ 30% prostate-specific antigen (PSA) decline by cycle 4 (C4) switched taxane. The primary clinical endpoint was confirmed ≥ 50% PSA decline versus historical control (TAX327)...
October 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28595188/physical-growth-and-biological-maturation-of-children-and-adolescents-proposed-reference-curves
#19
Daniel Leite Portella, Miguel Arruda, Rossana Gómez-Campos, Giovanna Checkin Portella, Cynthia Lee Andruske, Marco A Cossio-Bolaños
BACKGROUND/AIM: The study of physical growth variables in terms of chronological age and biological maturation may provide a common reference point to reflect on the occurrence of body dimensions in and between individuals. The objectives of this study were as follows: (a) verify if the observed gender differences in the variables of physical growth by chronological age are confounded by physical maturation, (b) compare physical growth patterns with the reference of the Centers for Disease Control and Prevention (CDC)-2012, and (c) develop regional curves to assess physical growth in terms of biological maturation...
2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28566721/a-novel-cxcr4-targeted-near-infrared-nir-fluorescent-probe-peptide-r-nir750-specifically-detects-cxcr4-expressing-tumors
#20
Sara Santagata, Luigi Portella, Maria Napolitano, Adelaide Greco, Crescenzo D'Alterio, Maria Vittoria Barone, Antonio Luciano, Matteo Gramanzini, Luigi Auletta, Claudio Arra, Antonella Zannetti, Stefania Scala
C-X-C chemokine receptor 4 (CXCR4) is over-expressed in multiple human cancers and correlates with tumor aggressiveness, poor prognosis and increased risk for distant metastases. Imaging agents for CXCR4 are thus highly desirable. We developed a novel CXCR4-targeted near-infrared (NIR) fluorescent probe (Peptide R-NIR750) conjugating the new developed CXCR4 peptidic antagonist Peptide R with the NIR fluorescent dye VivoTag-S750. Specific CXCR4 binding was obtained in cells overexpressing human CXCR4 (B16-hCXCR4 and human melanoma cells PES43), but not in CXCR4 low expressing cells (FB-1)...
May 31, 2017: Scientific Reports
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