Yong Zhu, Yanan Xiong, Xiaoyan Xu, Jin Zhang, Haiyang Tong, Hongyi Yang, Xia Niu, Xiaming Shi, Jiulai Tang, Jinhua Li
BACKGROUND: Cerebral palsy is a severe motor disability in childhood that poses challenges for children, families, and society. Rhesus macaques are the preferred animals for cerebral palsy model, but surgical excision of motor cortex has low success rate and high cost. In this work, we created cerebral palsy rhesus macaque models by intrathecal injection of bilirubin. METHODS: The puncture point for injection was identified as the intervertebral disc space two, located below the intersection of the iliac crest line and the posterior median line...
February 2024: Journal of Medical Primatology