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https://www.readbyqxmd.com/read/27920475/impact-of-frailty-on-approach-to-colonic-resection-laparoscopy-vs-open-surgery
#1
Catalina Mosquera, Konstantinos Spaniolas, Timothy L Fitzgerald
AIM: To understand the influence of frailty on postoperative outcomes for laparoscopic and open colectomy. METHODS: Data were obtained from the National Surgical Quality Improvement Program (2005-2012) for patients undergoing colon resection [open colectomy (OC) and laparoscopic colectomy (LC)]. Patients were classified as non-frail (0 points), low frailty (1 point), moderate frailty (2 points), and severe frailty (≥ 3) using the Modified Frailty Index. 30-d mortality and complications were used as the primary end point and analyzed for the overall population...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27881143/weekly-versus-every-three-weeks-platinum-based-chemoradiation-regimens-for-head-and-neck-cancer
#2
James M Melotek, Benjamin T Cooper, Matthew Koshy, Joshua S Silverman, Michael T Spiotto
BACKGROUND: The majority of chemoradiation (CRT) trials for locally advanced head and neck squamous cell carcinoma (HNSCC) have relied on platinum-based chemotherapy regimens administered every-3-weeks. However, given the increased utilization of weekly platinum regimens, it remains unclear how different chemotherapy schedules compare regarding efficacy and toxicity. METHODS: We retrospectively identified 212 patients with HNSCC who were treated at a single academic medical center with concurrent platinum-based CRT given weekly (N = 68) or every-three-weeks (N = 144)...
November 24, 2016: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/27866719/endocrine-surgery-fellowship-graduates-past-present-and-future-8%C3%A2-years-of-early-job-market-experiences-and-what-program-directors-and-trainees-can-expect
#3
Vikram D Krishnamurthy, Jesse Gutnick, Rachel Slotcavage, Judy Jin, Eren Berber, Allan Siperstein, Joyce J Shin
BACKGROUND: Given the increasing number of endocrine surgery fellowship graduates, we investigated if expectations and job opportunities changed over time. METHODS: American Association of Endocrine Surgeons (AAES) fellowship graduates, surgery department chairs, and physician recruiters were surveyed. Univariate analysis was performed with JMP Pro 12 software. RESULTS: We identified 141 graduates from 2008-2015; survey response rate was 72% (n = 101)...
November 17, 2016: Surgery
https://www.readbyqxmd.com/read/27739100/a-novel-semiquantitative-assessment-of-right-ventricular-systolic-function-with-a-modified-subcostal-echocardiographic-view
#4
José L Díaz-Gómez, Andres Borja Alvarez, Jonathan J Danaraj, Michelle L Freeman, Augustine S Lee, Farouk Mookadam, Brian P Shapiro, Harish Ramakrishna
OBJECTIVES: The tricuspid annular plane systolic excursion (TAPSE) is a validated measure of right ventricular function; however, the apical echocardiographic window varies and has limitations in intensive care unit (ICU) patients receiving mechanical ventilation or those with underlying disease and air entrapment. We aimed to evaluate the subcostal echocardiographic assessment of tricuspid annular kick (SEATAK) as an alternative to TAPSE in critically ill patients. METHODS: To measure SEATAK, we obtained the subcostal inferior vena cava view and used M-mode to measure excursion of the tricuspid annulus (kick)...
October 14, 2016: Echocardiography
https://www.readbyqxmd.com/read/27694242/from-anticipatory-corpse-to-posthuman-god
#5
Jeffrey P Bishop
The essays in this issue of JMP are devoted to critical engagement of my book, The Anticipatory Corpse The essays, for the most part, accept the main thrust of my critique of medicine. The main thrust of the criticism is whether the scope of the critique is too totalizing, and whether the proposed remedy is sufficient. I greatly appreciate these interventions because they allow me this occasion to respond and clarify, and to even further extend the argument of my book. In this response essay, I maintain that the regnant social imaginary of medicine is the regnant social imaginary of our time...
December 2016: Journal of Medicine and Philosophy
https://www.readbyqxmd.com/read/27636213/female-urethral-diverticulum-presentation-diagnosis-and-predictors-of-outcomes-after-surgery
#6
Sherif A El-Nashar, Ruchira Singh, Melissa M Bacon, Shunaha Kim-Fine, John A Occhino, John B Gebhart, Christopher J Klingele
INTRODUCTION AND HYPOTHESIS: To report on clinical presentation, diagnosis, and outcomes after treatment of female urethral diverticulum (UD). METHODS: Using a record linkage system, women with a new diagnosis of UD at Mayo Clinic from January 1, 1980, through December 31, 2011, were identified. The presenting symptoms, clinical characteristics, diagnosis, and management of women presenting with UD were recorded. Outcomes after surgery were assessed using survival analysis...
November 2016: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/27584600/age-and-fertility-a-study-on-patient-awareness
#7
Sara Deatsman, Terrie Vasilopoulos, Alice Rhoton-Vlasak
OBJECTIVE: Fertility declines as women age. Advancing maternal age increases pregnancy risks such as diabetes or hypertension. Studies suggest women are not aware of the risks of aging on fertility and pregnancy. The study objective was to assess women's knowledge of fertility and reproductive outcomes affected by aging. METHODS: Prospective IRB approved survey of women (n=94) attending an obstetrics and gynecology (OB/GYN) clinic. Data collected included demographics, pregnancy history, and knowledge of age-related fertility decline and pregnancy risks...
2016: JBRA Assisted Reproduction
https://www.readbyqxmd.com/read/27514658/esr1-erbb2-and-ki67-mrna-expression-predicts-stage-and-grade-of-non-muscle-invasive-bladder-carcinoma-nmibc
#8
Johannes Breyer, Ralph M Wirtz, Mark Laible, Kornelia Schlombs, Philipp Erben, Maximilian Christian Kriegmair, Robert Stoehr, Sebastian Eidt, Stefan Denzinger, Maximilian Burger, Arndt Hartmann, Wolfgang Otto
Pathological staging and grading are crucial for risk assessment in non-muscle-invasive bladder cancer (NMIBC). Molecular grading might support pathological evaluation and minimize interobserver variability. In this study, the well-established breast cancer markers ESR1, PGR, ERBB2, and MKI67 were evaluated as potential molecular markers to support grading and staging in NMIBC. We retrospectively analyzed clinical data and formalin-fixed paraffin-embedded tissues (FFPE) of patients with NMIBC. Messenger RNA (mRNA) expression of the aforementioned markers was measured by single-step reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) using RNA-specific TaqMan assays...
August 11, 2016: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27498618/development-of-a-method-for-the-n-arylation-of-amino-acid-esters-with-aryl-triflates
#9
Sandra M King, Stephen L Buchwald
A general method for the N-arylation of amino acid esters with aryl triflates is described. Both α- and β-amino acid esters, including methyl, tert-butyl, and benzyl esters, are viable substrates. Reaction optimization was carried out by design of experiment (DOE) analysis using JMP software. The mild reaction conditions, which use t-BuBrettPhos Pd G3 or G4 precatalyst, result in minimal racemization of the amino acid ester. This method is the first synthetic application of the t-BuBrettPhos Pd G4 precatalyst...
August 19, 2016: Organic Letters
https://www.readbyqxmd.com/read/27492786/variability-between-credit-units-dedicated-to-dental-and-clinical-sciences-in-dental-schools-across-the-usa
#10
Romesh P Nalliah, Michael S Forman, Sydnee E Chavis, Peggy Timothé
PURPOSE: The Commission of Dental Accreditation (CODA) does not set minimum standards for clock hours of training in Dental and Clinical sciences. The purpose of this evaluation was to compare United States (US) dental schools for variability in clock hours. The current paper utilizes the American Dental Association's survey of clock hours of all US dental schools which is publicly available data. Clock hours survey from 2010 to 2011 was utilized and the analysis tool, JMP, was utilized to visualize and report variability...
August 4, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27459973/in-vitro-evaluation-of-osteoblast-responses-to-carbon-nanotube-coated-titanium-surfaces
#11
K Subramani, S N Pandruvada, D A Puleo, J K Hartsfield, S S Huja
BACKGROUND: The effects of surface roughness and carboxyl functionalization of multi-walled carbon nanotubes (MWCNTs) mixed with collagen coated onto titanium (Ti) substrates on MC3T3-E1 osteoblasts were evaluated. METHODS: The proliferation, differentiation, and matrix mineralization were investigated using (1) smooth-surfaced Ti discs, (2) Ti discs coated with collagen and MWCNT (Ti-MWCNT), and (3) Ti discs coated with collagen and MWCNT-COOH (Ti-MWCNT-COOH) for applications in orthodontic mini screw implants (MSIs)...
December 2016: Progress in Orthodontics
https://www.readbyqxmd.com/read/27419270/target-properties-effects-on-central-versus-peripheral-vertical-fusion-interaction-tested-on-a-3d-platform
#12
Di Zhang, Pascaline Neveu, Yulia Fattakhova, Stéphanie Ferragut, Mathieu Lamard, Béatrice Cochener, Jean-Louis de Bougrenet de la Tocnaye
PURPOSE: We investigated the impact of target properties on vertical fusion amplitude (VFA) using a 3D display platform; the performance of the subjects allowed us to assess how central and peripheral retina regions interact during the fusion process. MATERIAL AND METHODS: Fourteen subjects were involved in the test. VFA was recorded by varying the viewing distance, target complexity, disparity velocity, lighting condition and background luminance. Base-up prisms were introduced to create vertical disparity in the peripheral retinal area, whereas an offset compensation was added in the central area...
July 15, 2016: Current Eye Research
https://www.readbyqxmd.com/read/27294398/excellent-intra-and-inter-observer-reproducibility-of-wrist-circumference-measurements-in-obese-children-and-adolescents
#13
Giuseppe Campagna, Simona Zampetti, Alessia Gallozzi, Sara Giansanti, Claudio Chiesa, Lucia Pacifico, Raffaella Buzzetti
In a previous study, we found that wrist circumference, in particular its bone component, was associated with insulin resistance in a population of overweight/obese children. The aim of the present study was to evaluate the intra- and inter-operator variability in wrist circumference measurement in a population of obese children and adolescents. One hundred and two (54 male and 48 female) obese children and adolescents were consecutively enrolled. In all subjects wrist circumferences were measured by two different operators two times to assess intra- and inter-operator variability...
2016: PloS One
https://www.readbyqxmd.com/read/27290840/-evaluation-of-semen-parameters-in-long-term-cryopreserved-samples-for-over-10-years
#14
A Kably-Ambe, E Carballo-Mondragón, A M Roque-Sánchez, L Durán-Monterosas, E A Amaro-Hernández
BACKGROUND: Sperm samples subjected to cryopreservation are vulnerable, reflecting changes in membrane integrity, mobility and DNA. OBJECTIVE: To assess the rate of DNA fragmentation, sperm mobility and recovery viability in capacitated semen samples after cryopreservation for over 10 years. MATERIAL AND METHOD: Longitudinal, prospective, observational study of 19 seminal samples cryopreserved for more than 10 years, in a mexican fertility center...
January 2016: Ginecología y Obstetricia de México
https://www.readbyqxmd.com/read/27274655/a-method-for-retrieval-of-adverse-event-terms-in-clinical-trial-databases-using-standardised-meddra-queries
#15
Christopher D Breder
BACKGROUND: Standardized MedDRA Queries (SMQs) are sets of terms determined by experts that are used to identify adverse events (AEs) related to different disease processes. Their use can be challenging because most SMQs have 50 to 100 preferred terms and AE databases can have many thousands of events. AIM: The aim of this study is to develop a technique where AEs corresponding to preferred terms in SMQs may be easily detected. METHODOLOGY: The method I developed uses the Table Join function of the JMP(®) software program to quickly and easily probe clinical trial AE databases...
April 2016: Pharmaceutical Medicine
https://www.readbyqxmd.com/read/27179246/varicose-veins-new-trends-in-treatment-in-a-vascular-surgery-unit
#16
Daniela P Mazzaccaro, Silvia Stegher, Maria Teresa Occhiuto, Lorenzo Muzzarelli, Giovanni Malacrida, Giovanni Nano
AIM: Less invasive techniques such as foam sclerotherapy, endovenous laser or radiofrequency ablation have recently been introduced as a valid alternative to surgery for the treatment of varicose veins (VVs). We retrospectively reviewed our experience in the treatment of VVs with particular attention to how our therapeutic approach has changed over the last years. MATERIAL OF STUDY: Data of all patients consecutively treated from September 1st 2013 to July 31st 2015 for both primitive and recurrent VVs were retrospectively collected and analyzed...
2016: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/27137907/growth-patterns-of-the-neurocentral-synchondrosis-ncs-in-immature-cadaveric-vertebra
#17
Laurel Blakemore, Richard Schwend, Behrooz A Akbarnia, Megan Dumas, John Schmidt
STUDY DESIGN: Gross anatomic study of osteological specimens. OBJECTIVES: To evaluate the age of closure for the neurocentral synchondrosis (NCS) in all 3 regions of the spine in children aged 1 to 18 years old. SUMMARY OF BACKGROUND DATA: The ossification of the human vertebra begins from a vertebral body ossification center and a pair of neural ossification centers located within the centrum called the NCS. These bipolar cartilaginous centers of growth contribute to the growth of the vertebral body, spinal canal, and posterior elements of the spine...
April 30, 2016: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/27017524/ophthalmic-surgical-simulation-in-training-dexterity-in-dominant-and-nondominant-hands-results-from-a-pilot-study
#18
Luis A Gonzalez-Gonzalez, Abhishek R Payal, Jose E Gonzalez-Monroy, Mary K Daly
PURPOSE: To determine whether a structured training program using the validated EYESI surgical simulator improves dexterity in nondominant (ND) hands. SETTING: Academic tertiary referral center. DESIGN: Nonrandomized, prospective study. METHODS: Subjects who chose to participate and provided informed consent completed a structured simulation training program, which included a baseline test, 3 sessions of repeated tasks, and a final test on capsulorhexis in dominant (D) and ND hands...
July 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/26994878/index-finger-pointing-in-generalized-tonic-clonic-seizures
#19
Jason Siegel, William O Tatum
OBJECTIVE: Most patients with localization-related epilepsy (LRE) and genetic generalized epilepsy (GGE) are classified based on semiology and video-EEG, but both features occasionally fail to provide a definitive diagnosis. Several reliable lateralizing signs have been described, although hand and finger posturing has received little attention. We sought to investigate the frequency of index-finger pointing (IFP) during generalized motor convulsions as a lateralizing semiology in LRE...
May 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/26910580/evaluating-serum-prolactin-and-serum-dehydroepiandrosterone-sulfate-levels-in-patients-with-pemphigus
#20
Maryam Yousefi, Nikoo Mozafari, Mahboobeh Sadat Hosseini, Sharareh Gholamin, Seyed-Mostafa Razavi, Mohammad Reza Namazi, Shima Younespour
BACKGROUND: Altered levels of sex hormones have been observed in many autoimmune disorders, but there is no considerable data about pemphigus. The aim of this study is to compare serum total and free prolactin and dehydroepiandrosterone sulfate (DHEAS) levels between patients with pemphigus and healthy controls and to determine the correlation of these hormones with disease severity. METHODS: This study included 52 newly diagnosed cases of pemphigus and 57 healthy controls...
June 2016: International Journal of Dermatology
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