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https://www.readbyqxmd.com/read/29330911/title-prognostic-significance-of-arterial-stiffness-and-osteoprotegerin-in-patients-with-stable-coronary-artery-disease
#1
Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Georgios Georgiopoulos, Eleni Kokkou, Vasiliki Tsigkou, Marina Zaromitidou, Alexis Antonopoulos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G Papavassiliou, Dimitris Tousoulis
BACKGROUND: Arterial stiffness and vascular calcification significantly contribute to coronary atherosclerosis progression. The prognostic value of increased arterial stiffness and vascular calcification in subjects with stable coronary artery disease (CAD) after percutaneous coronary intervention(PCI) is currently under question. MATERIALS AND METHODS: We randomly enrolled 262 patients with stable CAD one month after successful PCI. Carotid femoral pulse wave velocity (PWV) was measured as a well-established index of central aortic stiffness...
January 13, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29330891/why-do-african-american-have-a-higher-risk-for-cerebral-disease
#2
Shigehiko Ogoh
Clinical and epidemiological studies have reported significant racial differences in cardiovascular (CVD) and metabolic disease including hypertension, stroke, atherosclerosis, and type II diabetes which is most prevalent in the African American population. This article is protected by copyright. All rights reserved.
January 12, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29327078/the-role-of-the-thioredoxin-thioredoxin-reductase-system-in-the-metabolic-syndrome-towards-a-possible-prognostic-marker
#3
REVIEW
Alexey A Tinkov, Geir Bjørklund, Anatoly V Skalny, Arne Holmgren, Margarita G Skalnaya, Salvatore Chirumbolo, Jan Aaseth
Mammalian thioredoxin reductase (TrxR) is a selenoprotein with three existing isoenzymes (TrxR1, TrxR2, and TrxR3), which is found primarily intracellularly but also in extracellular fluids. The main substrate thioredoxin (Trx) is similarly found (as Trx1 and Trx2) in various intracellular compartments, in blood plasma, and is the cell's major disulfide reductase. Thioredoxin reductase is necessary as a NADPH-dependent reducing agent in biochemical reactions involving Trx. Genetic and environmental factors like selenium status influence the activity of TrxR...
January 11, 2018: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29321582/serum-podocalyxin-levels-correlate-with-carotid-intima-media-thickness-implicating-its-role-as-a-novel-biomarker-for-atherosclerosis
#4
Mayumi Shoji, Minoru Takemoto, Kazuki Kobayashi, Toshihiro Shoji, Satoka Mori, Jun-Ichi Sagara, Hiroyuki Kurosawa, Yoshiaki Hirayama, Kenichi Sakamoto, Takahiro Ishikawa, Masaya Koshizaka, Yoshiro Maezawa, Koutaro Yokote
Podocalyxin is a cell surface sialomucin, which is expressed in not only glomerular podocytes but also vascular endothelial cells. Urinary podocalyxin is used as a marker for glomerular disease. However, there are no reports describing serum podocalyxin (s-Podxl) levels. Therefore, the association between s-Podxl levels and clinical parameters were examined with 52 patients. s-Podxl level was evaluated using enzyme-linked immunosorbent assay. The median s-Podxl level was 14.2 ng/dL (interquartile range: 10...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310742/utility-of-arterial-stiffness-assessment-in-children
#5
Chaitanya Panchangam, Eric Dean Merrill, Geetha Raghuveer
Atherosclerotic cardiovascular disease is a leading cause of death and disability worldwide, and the atherosclerotic process begins in childhood. Prevention or containment of risk factors that accelerate atherosclerosis can delay the development of atherosclerotic cardiovascular disease. Although current recommendations are to periodically screen for commonly prevailing risk factors for atherosclerosis in children, a single test that could quantify the cumulative effect of all risk factors on the vasculature, thus assessing arterial health, would be helpful in further stratifying risk...
January 9, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29298404/predictors-of-obstructive-sleep-apnea-in-consecutive-patients-with-metabolic-syndrome
#6
Rodrigo P Pedrosa, Cristiane Maki-Nunes, Thiago Midlej-Brito, Heno F Lopes, Lunara S Freitas, Ivani C Trombetta, Edgar Toschi-Dias, Maria Janieire N N Alves, Raffael F Fraga, Maria U Rondon, Carlos E Negrão, Luiz A Bortolotto, Geraldo Lorenzi-Filho, Luciano F Drager
BACKGROUND: Recent evidence suggests that obstructive sleep apnea (OSA) is common in patients with metabolic syndrome (MetS) and may contribute to metabolic deregulation, inflammation, and atherosclerosis in these patients. In clinical practice, however, OSA is frequently underdiagnosed. We sought to investigate the clinical predictors of OSA in patients with MetS. METHODS: We studied consecutive patients newly diagnosed with MetS (Adult Treatment Panel-III). All participants underwent clinical evaluation, standard polysomnography, and laboratory measurements...
January 3, 2018: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/29297197/socioeconomic-status-and-cardiovascular-risk-score
#7
Ewa Podolecka, Agnieszka Doryńska, Paweł Nadrowski, Michał Skrzypek, Magdalena Kwaśniewska, Wojciech Drygas, Andrzej Pająk, Krystyna Kozakiewicz
BACKGROUND: Cardiovascular diseases are one of the most frequent causes of morbidity and death both in men and women. Well known is the influence of such factors as: hypertension, hypercholesterolemia, tobacco smoking, obesity, diabetes, age and sex on the occurrence and progression of atherosclerosis. Apart from the typical risk factors of cardiovascular diseases, there is also a significant association between the incidence of those diseases and the socioeconomic status (SES). AIM: The aim of this study was to establish the correlation between the socioeconomic status and the cardiovascular disease risk assessed according to the SCORE algorithm...
January 3, 2018: Kardiologia Polska
https://www.readbyqxmd.com/read/29290360/trimethylamine-n-oxide-a-harmful-protective-or-diagnostic-marker-in-lifestyle-diseases
#8
REVIEW
Artur Nowiński, Marcin Ufnal
Diet has been considered a general health determinant for many years. Recent research shows a connection between gut microbiota composition that is shaped by our diet and lifestyle diseases. Several studies point to a positive correlation between elevated plasma trimethylamine N-oxide (TMAO), a gut bacteria metabolite, and an increased risk for cardiovascular diseases, diabetes, and cancer. Therefore, it has been suggested that TMAO is a link between the diet, gut microbiota, and illness. Emerging experimental and clinical evidence shows that TMAO may be involved in the etiology of hypertension, atherosclerosis, coronary artery disease, diabetes, and renal failure...
February 2018: Nutrition
https://www.readbyqxmd.com/read/29285726/myocardial-perfusion-in-patients-with-non-ischaemic-systolic-heart-failure-and-type-2-diabetes-a-cross-sectional-study-using-rubidium-82-pet-ct
#9
Christina Byrne, Philip Hasbak, Andreas Kjaer, Jens Jakob Thune, Lars Køber
Both patients with non-ischaemic systolic heart failure and patients with type 2 diabetes (T2DM) often have reduced myocardial blood flow without significant coronary atherosclerosis. However, the mechanisms are not fully understood. The aim of this study was to investigate whether perfusion is reduced additionally when the 2 are combined. In a cross-sectional study, we scanned patients with non-ischaemic systolic heart failure with and without T2DM using Rubidium-82 positron emission tomography/computed tomography at rest and adenosine-induced stress, thereby obtaining the myocardial flow reserve (myocardial flow reserve (MFR) = stress flow/rest flow) as a measure of the myocardial vasomotor function; 28 patients with T2DM and 123 without T2DM were included...
December 28, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29273191/a-simple-community-based-risk-prediction-score-for-sudden-cardiac-death
#10
Brittany M Bogle, Hongyan Ning, Jeffrey J Goldberger, Sanjay Mehrotra, Donald M Lloyd-Jones
BACKGROUND: Although sudden cardiac death is a leading cause of death in the United States, most victims of sudden cardiac death are not identified as at-risk prior to death. We sought to derive and validate a population-based risk score that predicts sudden cardiac death. METHODS: The Atherosclerosis Risk in Communities (ARIC) Study recorded clinical measures from men and women aged 45-64 at baseline; 11,335 white and 3,780 black participants were included in this analysis...
December 19, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29239466/rupture-of-the-myocardium-in-autopsied-mi-hearts
#11
Valesca Bizinoto Monteiro, Bianca Gonçalves Silva Torquato, Guilherme Ribeiro Juliano, Bárbara Cecílio da Fonseca, Flávia Aparecida de Oliveira, Daniel Ferreira da Cunha, Camila Lourencini Cavellani, Luciano Alves Matias da Silveira, Mara Lúcia da Fonseca Ferraz, Vicente de Paula Antunes Teixeira, Edson Luiz Fernandes
Although myocardial rupture occurs in only 2% to 4% of cases of acute myocardial infarction (AMI), there is a high mortality rate due to acute cardiogenic shock. We present the anatomopathological findings of three cases of myocardial rupture in autopsied hearts in the last 30 years, with a diagnosis of cardiac rupture in acute myocardial infarction. In these 30 years the percentage of AMI with myocardial rupture was 0.2%. Risk factors for post-AMI myocardial rupture include older age, atherosclerosis, diabetes mellitus and systemic arterial hypertension...
September 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/29238435/primary-aldosteronism-with-type-2-diabetes-mellitus-requires-more-antihypertensive-drugs-for-blood-pressure-control-a-retrospective-observational-study
#12
Kennosuke Ohashi, Takeshi Hayashi, Yui Watanabe, Koichiro Hara, Rikako Ukichi, Hiroshi Asano, Hirofumi Suzuki, Kenji Yamashiro, Katsuyoshi Tojo, Masaya Sakamoto, Kazunori Utsunomiya
Background: Diabetes mellitus (DM) and primary aldosteronism (PA) have been reported to induce drug-resistant hypertension and atherosclerosis. It is likely that blood pressure (BP) control becomes far more difficult in PA patients with DM. However, precise clinical characteristics of PA with type 2 DM especially in the aspect of BP control are not clear. Methods: The study included 18 patients who were diagnosed as PA with DM and 52 PA patients without DM who matched age and sex and chosen as a control group...
January 2018: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29228671/metformin-ameliorates-skeletal-muscle-insulin-resistance-by-inhibiting-mir-21-expression-in-a-high-fat-dietary-rat-model
#13
Jinyang Wang, Yanbin Gao, Lijun Duan, Suhong Wei, Jing Liu, Liming Tian, Jinxing Quan, Qi Zhang, Juxiang Liu, Jinkui Yang
Insulin resistance (IR) plays a major role in the pathogenesis of abdominal obesity, hypertension, coronary heart disease, atherosclerosis and diabetes. miR-21 and TGF-β/smads is closely related to IR. However, it remained elusive whether metformin improved skeletal muscle insulin resistance (IRSM) by regulating miR-21 and its target signal TGF-β1/smads expression. In this study, high-fat diet rats with IR model and IR-skeletal muscle L6 cells (L6-SMCs) model were established, insulin sensitive index (ISI) and Homeostasis model assessment of IR (HOMA-IR) were applied, miR-21 and TGF-β1/smads mRNA expression were examined by RT-PCR, smad3 and smad7 protein were detected by western-blotting and laser scanning confocal microscopy (LSCM), the valid target of miR-21 was detected by luciferase reporter gene assay...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29227868/systemic-mastocytosis-associates-with-cardiovascular-events-despite-lower-plasma-lipid-levels
#14
Swasti Indhirajanti, Paul L A van Daele, Sven Bos, Monique T Mulder, Ilze Bot, Jeanine E Roeters van Lennep
BACKGROUND AND AIMS: Mast cells have been implicated in the development and progression of atherosclerosis in animal models and human autopsy studies. However, it is unknown whether long-term exposure to excess of mast cells is associated with cardiovascular disease (CVD) in humans. Our objective was to compare the prevalence of CVD and cardiovascular risk factors in patients with systemic mastocytosis (SM) and controls. METHODS: In 50 patients with SM and 50 age and sex matched controls, the history of CVD and presence of cardiovascular risk factors were assessed...
December 8, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29226654/evaluation-of-hepcidin-and-atherosclerosis-in-dialysis-patients
#15
Victor Manolov, Julia Petrova, Boris Bogov, Savina Hadjidekova, Vasil Vasilev, Dyana Yonova, Maria Petrova, Todor Kunchev, Yavor Jelev, Petar Jeliazkov, Borislav Marinov, Ivo Bogov, Zlatina Gramatikova, Silviya Voleva, Kamen Tzatchev, Latchezar Traykov
BACKGROUND: Chronic kidney disease (CKD) is a condition that involves 10% - 15% of population worldwide, which increases the risk of cardio-vascular diseases (CVD). Chronic kidney disease is one of the main reasons for illness and mortality in the world. Chronic kidney disease is a serious health problem caused by involvement of a large number of patients with kidney injury, especially in industrial countries. Among the main reasons for this are population living longer and the number of diseases in elderly persons, such as diabetes mellitus type 2, hypertension, and cardio-vascular diseases...
November 1, 2017: Clinical Laboratory
https://www.readbyqxmd.com/read/29210129/effect-of-resveratrol-and-pterostilbene-on-aging-and-longevity
#16
REVIEW
Yi-Rong Li, Shiming Li, Chi-Chien Lin
Over the past years, several studies have found that foods rich in polyphenols protect against age-related disease, such as atherosclerosis, cardiovascular disease, cancer, arthritis, cataracts, osteoporosis, type 2 diabetes (T2D), hypertension and Alzheimer's disease. Resveratrol and pterostilbene, the polyphenol found in grape and blueberries, have beneficial effects as anti-aging compounds through modulating the hallmarks of aging, including oxidative damage, inflammation, telomere attrition and cell senescence...
December 6, 2017: BioFactors
https://www.readbyqxmd.com/read/29207114/elderly-apolipoprotein-e%C3%A2-%C3%A2-mice-with-advanced-atherosclerotic-lesions-in-the-aorta-do-not-develop-alzheimer-s-disease-like-pathologies
#17
Reut Shnerb Ganor, Dror Harats, Ginette Schiby, Kinneret Rosenblatt, Irit Lubitz, Aviv Shaish, Ophira Salomon
Atherosclerosis and Alzheimer's disease (AD) are a major cause of morbidity and mortality in Western societies. These diseases share common risk factors, which are exhibited in old age, including hypertension, diabetes, hypercholesterolemia and apolipoprotein (Apo) ε4 allele. We previously demonstrated that factor XI (FXI) deficiency in mice reduced the atherosclerotic plaque area in coronary sinuses and the aortic arch. This led us to investigate whether FXI deficiency in elderly ApoE knockout (KO) mice would decrease pathological alterations compatible with atherosclerosis and AD...
November 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205099/adiponectin-leptin-ratio-a-promising-index-to-estimate-adipose-tissue-dysfunction-relation-with-obesity-associated-cardiometabolic-risk
#18
Gema Frühbeck, Victoria Catalán, Amaia Rodríguez, Javier Gómez-Ambrosi
Obesity is currently the most extended metabolic disturbance worldwide favoring the development of cardiometabolic alterations such as type 2 diabetes, hypertension, and dyslipidemia. Obesity and the metabolic syndrome (MS) are characterized by an increase in circulating leptin concentrations, in parallel to a decrease in blood levels of adiponectin. Consequently, the adiponectin/leptin ratio has been suggested as a maker of adipose tissue dysfunction. This emerging biomarker correlates with insulin resistance better than adiponectin or leptin alone, or even HOMA and is decreased with increasing number of metabolic risk factors having been proposed as a predictive marker for the MS...
December 5, 2017: Adipocyte
https://www.readbyqxmd.com/read/29197188/genipin-alleviates-high-fat-diet-induced-hyperlipidemia-and-hepatic-lipid-accumulation-in-mice-via-mir-142a-5p-srebp-1c-axis
#19
Hong Zhong, Ke Chen, Mengyang Feng, Wei Shao, Jun Wu, Kun Chen, Tingming Liang, Chang Liu
Hyperlipidemia is a chronic disorder which plays an important role in the development of cardiovascular diseases, type 2 diabetes, atherosclerosis, hypertension and nonalcoholic fatty liver disease. Genipin is a metabolite from genipioside, which is an active component of the traditional Chinese medicine Gardenia jasminoides Ellis, and has been recognized as a beneficial compound against metabolic disorders. However, whether it can correct over-nutrition-induced dyslipidemia is still unknown. In this study, the effects of genipin on attenuating hyperlipidemia and hepatic lipid accumulation were investigated using normal and obese mice induced by a high-fat diet and primary hepatocytes treated by free fatty acids...
December 2, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29196693/relationship-between-erectile-dysfunction-and-the-neutrophil-to-lymphocyte-and-platelet-to-lymphocyte-ratios
#20
Murat Sambel, Metin Kilic, Murat Demirbas, Efe Onen, Sedat Oner, Abdullah Erdogan, Mustafa Murat Aydos
The most important cause of erectile dysfunction (ED) among aging men is organic disease due to vascular disturbance that is often caused by atherosclerosis. Recently, studies have shown that atherosclerosis can manifest as an active inflammatory process rather than as passive vascular injury caused by lipid infiltration. Our study aimed to examine the association of ED with the neutrophil/lymphocyte ratio (NLR) and the platelet/lymphocyte ratio (PLR), both of which are markers of inflammation. Between December 2014 and May 2015, 101 male patients aged 40-70 years who were seen at our institute due to ED were included in this study...
December 1, 2017: International Journal of Impotence Research
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