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https://www.readbyqxmd.com/read/28534318/association-between-inflammatory-skin-disease-and-cardiovascular-and-cerebrovascular-co-morbidities-in-us-adults-analysis-of-nationwide-inpatient-sample-data
#1
Michael C Kwa, Jonathan I Silverberg
BACKGROUND: Psoriasis, atopic dermatitis or eczema (AD-E), pemphigus, bullous pemphigoid (BP), and hidradenitis are chronic inflammatory skin disorders associated with systemic immune activation, considerable symptom burden, stigma, functional disturbances, and mental health symptoms. All of these might increase cardiovascular risk. OBJECTIVE: The objective of this study was to determine whether these inflammatory skin diseases are associated with increased cardiovascular/cerebrovascular risk and/or disease...
May 22, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28532894/-spanish-adaptation-of-the-2016-european-guidelines-on-cardiovascular-disease-prevention-in-clinical-practice
#2
Miguel Ángel Royo-Bordonada, Pedro Armario, José María Lobos Bejarano, Juan Pedro-Botet, Fernando Villar Álvarez, Roberto Elosua, Carlos Brotons Cuixart, Olga Cortés, Benilde Serrano, Miguel Camafort Babkowski, Antonio Gil Núñez, Antonio Pérez, Antonio Maiques, Ana de Santiago Nocito, Almudena de Castro, Eduardo Alegría, Ciro Baeza, María Herranz, Susana Sans, Pilar Campos
The VI European Guidelines for Cardiovascular Prevention recommend combining population and high-risk strategies with lifestyle changes as a cornerstone of prevention, and propose the SCORE function to quantify cardiovascular risk. The guidelines highlight disease specific interventions, and conditions as women, young people and ethnic minorities. Screening for subclinical atherosclerosis with noninvasive imaging techniques is not recommended. The guidelines distinguish four risk levels (very high, high, moderate and low) with therapeutic objectives for lipid control according to risk...
May 19, 2017: Semergen
https://www.readbyqxmd.com/read/28530333/-the-impact-of-a-community-intervention-program-in-israeli-worksites-to-reduce-the-risk-of-cardiovascular-diseases
#3
Chaim Yosefy, Noa Oliel, Aviva Grosbirt, Doron Levy, Dov Gavish, Dror Dicker, Reuven Viskoper
INTRODUCTION: Atherosclerosis is the main cause of cardiovascular (CV) morbidity and mortality in the western world. Detection and treatment of risk factors (such as hypertension, dyslipidemia and diabetes mellitus) reduce CV events. We have shown cost utility in reducing these CV risk factors in community clinics and community centers. AIMS: In this paper we focused on community workplaces. METHODS: We included 1011 workers in 15 worksites in the study...
August 2016: Harefuah
https://www.readbyqxmd.com/read/28530081/-evaluation-of-the-association-between-antihypertensive-treatment-and-development-of-stroke
#4
Margarita Fraimovitch, Yosef Tzvi, Reuven Zimlichman
INTRODUCTION: An ischemic stroke is an event that occurs due to cerebral vascular disease and is directly related to the degree of vascular damage. This process is associated with atherosclerosis progression and is influenced by the presence of cardiovascular risk factors. AIMS: One of the goals of our research was to examine whether specific medications used for treating hypertension are associated with the development of strokes. METHODS: In a retrospective study of patients who were hospitalized between the years 2003-2008 due to a cerebrovascular accident (CVA) or a transient ischemic attack (TIA), 916 cases of stroke patients were reviewed...
September 2016: Harefuah
https://www.readbyqxmd.com/read/28529917/current-guidelines-on-prevention-with-a-focus-on-dyslipidemias
#5
REVIEW
Ian M Graham, Alberico L Catapano, Nathan D Wong
Examination of the current the American College of Cardiology/American Heart Association (ACC/AHA) and European Society of Cardiology/European Atherosclerosis Society (ESC/EAS) guidelines on the prevention of cardiovascular disease and the management of dyslipidemias finds much common ground. Both note that Atherosclerotic cardiovascular disease (ASCVD) is, in most people, the product of a number of risk factors, notably tobacco exposure, hyperlipidemia, hypertension, inactivity, overweight and diabetes. They stress that risk calculators can help in the assessment of risk in apparently healthy persons...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28529751/comparison-of-lifestyle-hormonal-and-medical-factors-in-women-with-sporadic-and-lynch-syndrome-associated-endometrial-cancer-a-retrospective-case-case-study
#6
Mari H Aaltonen, Synnöve Staff, Jukka-Pekka Mecklin, Kirsi Pylvänäinen, Johanna U Mäenpää
Data available on lifestyle-associated hormonal and medical factors among endometrial cancer (EC)-affected women who carry the Lynch Syndrome (LS) mutation is limited. The aim of the present retrospective case study was to compare the reproductive and medical history, as well as lifestyle-associated factors, among patients with LS and sporadic EC. The study population consisted of 50 verified germline mismatch repair (MMR) gene mutation carriers diagnosed with EC, and 110 sporadic EC patients. Data were collected using postal questionnaires...
May 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28524151/-etiopathogenesis-of-ocular-ischemic-syndrome
#7
D К Makhkamova
Ocular ischemic syndrome (OIS) is a collection of symptoms of carotid and ophthalmic artery disease of common genesis accompanied by ischemia of eyeball membranes. Specifically, the intraocular blood flow becomes impaired due to inflow reduction or arrest, while the venous outflow remains patent. Causes of OIS include arterial hypertension, atherosclerosis, diabetes, aortoarteritis and other vascular diseases. Clinical features depend on the extent, nature, and site of vascular involvement as well as the concurrent pathology...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/28511475/colour-doppler-evaluation-of-extracranial-carotid-artery-in-patients-presenting-with-acute-ischemic-stroke-and-correlation-with-various-risk-factors
#8
Samrin Haq, Manoj Mathur, Jasvir Singh, Navkiran Kaur, Raminderpal Singh Sibia, Rajesh Badhan
INTRODUCTION: Stroke is defined as an abrupt onset of neurologic deficit due to vascular cause. It is one of the leading causes of mortality and morbidity all over the world making early diagnosis and treatment inevitable. Lesions of extra cranial carotid arteries are implicated in majority of cases of acute ischemic stroke. Carotid Doppler is a non-invasive imaging technique, with sensitivity approaching that of angiography. Computed Tomography (CT) plays a major role to assess the site and nature of the lesion in patients with acute ischemic stroke...
March 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28508856/microvascular-complications-of-type-2-diabetes-mellitus-are-associated-with-plaque-score-in-the-carotid-arteries
#9
Wojciech Bartman, Katarzyna Nabrdalik, Hanna Kwiendacz, Tomasz Sawczyn, Andrzej Tomasik, Krystyna Pierzchała, Monika Adamczyk-Sowa, Agnieszka Machowska-Majchrzak, Beata Łabuz-Roszak, Władysław Grzeszczak, Janusz Gumprecht
INTRODUCTION    The "common soil" hypothesis suggests that diabetic micro- and macroangiopathy arise from a similar pathophysiological has been once proposed. It is well documented that carotid artery atherosclerosis in patients with type 2 diabetes mellitus (T2DM) is associated with cardiovascular complications; however, whether microvascular complications are similarly related remains unclear. OBJECTIVES    We aimed to explore whether plaque score or common carotid artery intima-media thickness (CIMT) is associated with the macroangiopathic or microangiopathic complications of T2DM...
May 16, 2017: Polish Archives of Internal Medicine
https://www.readbyqxmd.com/read/28499385/target-organ-damage-and-incident-type-2-diabetes-mellitus-the-strong-heart-study
#10
Giovanni de Simone, Wenyu Wang, Lyle G Best, Fawn Yeh, Raffaele Izzo, Costantino Mancusi, Mary J Roman, Elisa T Lee, Barbara V Howard, Richard B Devereux
BACKGROUND: Recent analyses in a registry of hypertensive patients suggested that preceding left ventricular (LV) hypertrophy (LVH) and/or carotid atherosclerosis are associated with incident type 2 diabetes, independent of confounders. We assess the relation between prevalent cardio-renal target organ damage (TOD) and subsequent incident type 2 diabetes in a population-based study with high prevalence of obesity. METHODS: We selected 2887 non-diabetic participants from two cohorts of the Strong Heart Study (SHS)...
May 12, 2017: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/28498145/brief-report-progression-of-atherosclerosis-in-hiv-infected-individuals-prospective-data-from-an-asian-cohort
#11
Grace Lui, Ronald C W Ma, Ping Chook, Chun-Kwok Wong, Claudia H T Tam, Michael H M Chan, Shui-Shan Lee, Rity Y K Wong, Catherine S K Cheung, Kin-Wing Choi, Ping-Chung Leung, Ka-Hing Wong, Kenny C W Chan, Nelson Lee
BACKGROUND: The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1) the rate of progression of atherosclerosis in HIV-infected individuals, and (2) metabolic and inflammatory parameters that may predict atherosclerosis progression in HIV-infected individuals in an Asian cohort. SETTING: A prospective, longitudinal study was performed among adults attending an HIV Metabolic clinic in Hong Kong...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28495650/extent-of-coronary-artery-disease-in-patients-undergoing-angiography-for-stable-or-acute-coronary-syndromes
#12
Aikaterini Marini, Katerina K Naka, Konstantinos Vakalis, Aris Bechlioulis, Mara Bougiakli, Sophia Giannitsi, Konstantina Nikolaou, Emorfili Ioanna Antoniadou, Constantina Gartzonika, Georgios Chasiotis, Eleni Bairaktari, Christos S Katsouras, Georgios Triantis, Dimitrios Sionis, Lampros K Michalis
PURPOSE: We aimed to investigate whether the angiographic extent of coronary artery disease (CAD) may differ in patients undergoing coronary angiography for stable CAD or an acute coronary syndrome (ACS) and identify predictors of CAD extent in these patients. METHODS: We enrolled 584 consecutive patients (463 with stable CAD, 121 with ACS) with angiographically established CAD (≥1 stenosis >25%). The Gensini score was used to assess the extent of coronary atherosclerosis...
May 8, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/28490753/wbc-count-predicts-the-risk-of-new-onset-peripheral-arterial-disease-in-a-chinese-community-based-population
#13
Yuxi Li, Fangfang Fan, Jia Jia, Jianping Li, Yong Huo, Yan Zhang
This longitudinal cohort study investigated whether peripheral WBC counts could predict peripheral arterial disease (PAD) incidence after a 2.3-year follow-up in a Chinese community-based population without PAD at baseline. A total of 3555 Chinese subjects without fever and PAD at baseline from an atherosclerosis cohort were included in our analysis. The ankle brachial index (ABI) was measured, and PAD was defined as an ABI <0.9. Multivariate regression models were used to evaluate the association of WBC count and new-onset PAD...
May 11, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28487672/the-g-protein-coupled-receptor-ut-of-the-neuropeptide-urotensin-ii-displays-structural-and-functional-chemokine-features
#14
REVIEW
Hélène Castel, Laurence Desrues, Jane-Eileen Joubert, Marie-Christine Tonon, Laurent Prézeau, Marie Chabbert, Fabrice Morin, Pierrick Gandolfo
The urotensinergic system was previously considered as being linked to numerous physiopathological states, including atherosclerosis, heart failure, hypertension, pre-eclampsia, diabetes, renal disease, as well as brain vascular lesions. Thus, it turns out that the actions of the urotensin II (UII)/G protein-coupled receptor UT system in animal models are currently not predictive enough in regard to their effects in human clinical trials and that UII analogs, established to target UT, were not as beneficial as expected in pathological situations...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28483775/age-specific-vascular-risk-factor-profiles-according-to-stroke-subtype
#15
Allard J Hauer, Ynte M Ruigrok, Ale Algra, Ewoud J van Dijk, Peter J Koudstaal, Gert-Jan Luijckx, Paul J Nederkoorn, Robert J van Oostenbrugge, Marieke C Visser, Marieke J Wermer, L Jaap Kappelle, Catharina J M Klijn
BACKGROUND: Ischemic and hemorrhagic stroke are increasingly recognized as heterogeneous diseases with distinct subtypes and etiologies. Information on variation in distribution of vascular risk factors according to age in stroke subtypes is limited. We investigated the prevalence of vascular risk factors in stroke subtypes in relation to age. METHODS AND RESULTS: We studied a prospective multicenter university hospital-based cohort of 4033 patients. For patients with ischemic stroke caused by large artery atherosclerosis, small vessel disease, or cardioembolism and for patients with spontaneous intracerebral hemorrhage or aneurysmal subarachnoid hemorrhage, we calculated prevalences of vascular risk factors in 4 age groups: <55, 55 to 65, 65 to 75, and ≥75 years, and mean differences with 95% CIs in relation to the reference age group...
May 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28481400/polymorphism-of-the-gene-enos-g894t-glu298asp-in-symptomatic-patients-with-aterosclerosis
#16
F L Campedelli, K S F E Silva, D A Rodrigues, J V M Martins, I R Costa, M H Lagares, A M Barbosa, M P de Morais, K K V O Moura
Atherosclerotic and its cardiovascular complications are responsible for 17.5 million deaths a year, according to the World Health Organization. There is consensus that atherosclerosis involves multiple pathogenic processes initiated by endothelial dysfunction, with inflammation and vascular proliferation determining alterations in the matrix, with consequent formation of the atheromatous plaque and its clinical implications. Risk factors such as hypertension, diabetes mellitus, dyslipidemia, and smoking are widely known...
May 4, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28479908/determinants-of-isolated-systolic-hypertension-among-diabetic-patients-visiting-the-diabetic-clinic-at-the-tamale-teaching-hospital-northern-ghana
#17
Richard Kd Ephraim, Abdul-Razak Saasi, Enoch O Anto, Prince Adoba
BACKGROUND: Hypertension and diabetes mellitus, two of the leading risk factors for atherosclerosis, are associated with numerous complications, including heart attacks and strokes. AIM: This study established the prevalence and determinants of isolated systolic hypertension (ISH) in diabetes mellitus patients visiting the Tamale Teaching Hospital. MATERIALS AND METHODS: In this purposive cross-sectional study, 107 diabetes mellitus patients were recruited from the out-patient diabetes clinic of the Tamale Teaching Hospital (TTH)...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28476875/traditional-cardiovascular-risk-factors-and-their-relation-to-future-surgery-for-valvular-heart-disease-or-ascending-aortic-disease-a%C3%A2-case-referent-study
#18
Johan Ljungberg, Bengt Johansson, Karl Gunnar Engström, Elin Albertsson, Paul Holmer, Margareta Norberg, Ingvar A Bergdahl, Stefan Söderberg
BACKGROUND: Risk factors for developing heart valve and ascending aortic disease are based mainly on retrospective data. To elucidate these factors in a prospective manner, we have performed a nested case-referent study using data from large, population-based surveys. METHODS AND RESULTS: A total of 777 patients operated for heart valve disease or disease of the ascending aorta had previously participated in population-based health surveys in Northern Sweden. Median time (interquartile range) from survey to surgery was 10...
May 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28475940/lp-pla2-activity-and-mass-for-prediction-of-incident-abdominal-aortic-aneurysms-a-prospective-longitudinal-cohort-study
#19
Stefan Acosta, Soumia Taimour, Anders Gottsäter, Margaretha Persson, Gunnar Engström, Olle Melander, Moncef Zarrouk, Peter M Nilsson, J Gustav Smith
BACKGROUND AND AIMS: The pathogenesis of abdominal aortic aneurysm (AAA) shares several common pathways with atherosclerosis. Prospective clinical plasma biomarker studies in AAA have been hampered by the need for very large cohorts and long follow-up time. METHODS: We analyzed a prospective longitudinal cohort of middle-aged individuals from the cardiovascular cohort of the Malmö Diet and Cancer study (n = 5551; 1991-94). The plasma biomarkers lipoprotein-associated phospholipase A2 (Lp-PLA2 activity and mass), proneurotensin and C-reactive protein, and conventional risk factors at baseline were measured in patients with incident AAA during follow-up, and compared to individuals without a diagnosis of AAA...
April 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28473221/cyp2c19-activity-and-cardiovascular-risk-factors-in-patients-with-an-acute-coronary-syndrome
#20
Efrén Martínez-Quintana, Fayna Rodríguez-González, José María Medina-Gil, Paloma Garay-Sánchez, Antonio Tugores
INTRODUCTION: CYP2C19 is a major isoform of cytochrome P450 that metabolizes a number of drugs and is involved in the glucocorticoids synthesis. CYP2C19 polymorphisms have been associated with the genetic risk for type 2 diabetes. METHODS: Five hundred and three patients with an acute coronary event were studied to assess the association between the CYP2C19 activity (CYP2C19*2, CYP2C19*3 and CYP2C19*17 variants) and the type of acute coronary syndrome, cardiovascular risk factors (arterial systemic hypertension, diabetes mellitus, dyslipidemia and smoking), analytical parameters and the extent and severity of coronary atherosclerosis...
May 1, 2017: Medicina Clínica
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