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https://www.readbyqxmd.com/read/27905030/involvement-of-the-coronary-bed-in-patients-with-coronary-heart-disease-against-the-background-of-primarily-coronary-and-generalized-atherosclerosis
#1
M A Bakarev, A A Karpova, V I Pichigin, D B Nikityuk, E L Lushnikova
Significant associations between clinical history factors, lipid metabolism parameters, and type of atherosclerotic process (area of vascular lesions and severity of clinical manifestations) were detected. The predominance of generalized atherosclerosis in chronic coronary heart disease group was associated with patients' age, more incident excessive body weight and type 2 diabetes mellitus, and more severe course of arterial hypertension. Increased lipid spectrum atherogenicity was significantly more often observed in generalized atherosclerosis in the myocardial infarction group...
December 1, 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27903374/-the-relationship-between-myocardial-bridge-in-mural-coronary-artery-segment-and-coronary-atherosclerosis
#2
S J Ding, R C Huang, C F Jia, L Zhong, P An, Z Q Wang, H Zhu, B L Wu, X C Zhou
Objective: The myocardial bridging (MB) prevalence, anatomic characteristics of MB, and the relationship between characteristics of MB in mural coronary artery segment and coronary atherosclerosis were analyzed. Methods: In this perspective nonrandomized controlled study, a total of 1 132 patients who admitted to our hospital for suspected or known coronary artery disease from January 2012 to June 2013 were enrolled. All patients underwent dual-source 64-slice spiral CT coronary angiography. The general patient characteristics including gender, age, history of hypertension, diabetes, hyperlipidemia and smoking, serum level of total cholesterol (TC) and LDL-C were recorded...
October 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/27899247/association-of-plasma-fetuin-a-levels-with-peripheral-arterial-disease-and-lower-extremity-arterial-calcification-in-subjects-with-type-2-diabetes-mellitus
#3
Ioanna Eleftheriadou, Pinelopi Grigoropoulou, Alexander Kokkinos, Iordanis Mourouzis, Despoina Perrea, Nicholas Katsilambros, Petros P Sfikakis, Nikolaos Tentolouris
AIMS: Fetuin-A is a hepatic glycoprotein that is involved in insulin resistance and atherosclerosis. Herein we examined the association of plasma fetuin-A levels with peripheral arterial disease (PAD) in patients with type 2 diabetes mellitus (T2DM). MATERIAL AND METHODS: A total of 71 patients with T2DM and 57 non-diabetic individuals were recruited. Diagnosis of PAD was based on the absence of triphasic waveform at pedal arteries, while ankle-brachial index (ABI) was calculated...
November 12, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27894949/intravascular-hemodynamics-and-coronary-artery-disease-new-insights-and-clinical-implications
#4
REVIEW
Marina Zaromytidou, Gerasimos Siasos, Ahmet U Coskun, Michelle Lucier, Antonios P Antoniadis, Michail I Papafaklis, Konstantinos C Koskinas, Yannis Andreou, Charles L Feldman, Peter H Stone
Understanding of the pathophysiological mechanisms is the cornerstone of preventive and treatment strategies in the battle against coronary artery disease. Hyperlipidemia, arterial hypertension, smoking and diabetes, are established risk factors affecting coronary vasculature. However, the focal formation of atherosclerotic lesions in certain arterial regions underscores that local factors are implicated in the initiation and progression of atherosclerosis. Introduction of novel imaging modalities and technological advances offered new insights and acknowledged intravascular hemodynamics, and particularly flow-derived endothelial shear stress as a critical factor in the natural history of coronary artery disease...
November 25, 2016: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/27894808/protective-effect-of-betulinic-acid-on-early-atherosclerosis-in-diabetic-apolipoprotein-e-gene-knockout-mice
#5
Jung Joo Yoon, Yun Jung Lee, Byung Hyuk Han, Eun Sik Choi, Min Chul Kho, Ji Hun Park, You Mee Ahn, Hye Yoom Kim, Dae Gill Kang, Ho Sub Lee
Atherosclerosis, a chronic and progressive disease, is a leading cause of endothelial dysfunction, diabetes mellitus, hypertension, and hypercholesterolemia. Betulinic acid (BA), a pentacyclic triterpene, has been reported to have a variety of biological effects, including anti-inflammatory and immunomodulatory properties. This study was designed to determine whether BA could prevent atherosclerosis in diabetic apolipoprotein-E gene knockout (ApoE KO) mice. The mice were treated with BA for 12 weeks to examine its beneficial effects on atherosclerosis in ApoE KO mice...
November 25, 2016: European Journal of Pharmacology
https://www.readbyqxmd.com/read/27883326/renal-replacement-therapy-in-patients-with-heart-and-kidney-failure
#6
Dimitrios S Goumenos, Evangelos Papachristou, Marios Papasotiriou
The incidence of chronic kidney disease (CKD) in patients with chronic heart failure (CHF) is high as CKD and CHF share underlying risk factors such as arterial hypertension, diabetes mellitus and atherosclerosis. Cardiac failure leads to renal hypoperfusion and dysfunction and then fluid overload and need for aggressive diuretic therapy. However, development of diuretic resistance represents a significant problem in the management of these patients. The role of Renal Replacement Therapy (RRT) is important for patients who do not response to conservative management of fluid overload facilitating the failing heart to restore function...
November 1, 2016: Prilozi (Makedonska Akademija Na Naukite i Umetnostite. Oddelenie za Medicinski Nauki)
https://www.readbyqxmd.com/read/27881565/low-dose-aspirin-for-primary-prevention-of-cardiovascular-events-in-patients-with-type-2-diabetes-10-year-follow-up-of-a-randomized-controlled-trial
#7
Yoshihiko Saito, Sadanori Okada, Hisao Ogawa, Hirofumi Soejima, Mio Sakuma, Masafumi Nakayama, Naofumi Doi, Hideaki Jinnouchi, Masako Waki, Izuru Masuda, Takeshi Morimoto
BACKGROUND: -The long-term efficacy and safety of low-dose aspirin for primary prevention of cardiovascular events in patients with type 2 diabetes are still inconclusive. METHODS: -The Japanese Primary Prevention of Atherosclerosis with Aspirin for Diabetes (JPAD) trial was a randomized, open-label, standard-care controlled trial examining whether low-dose aspirin affected cardiovascular events in 2539 Japanese patients with type 2 diabetes and without pre-existing cardiovascular disease...
November 15, 2016: Circulation
https://www.readbyqxmd.com/read/27880755/-spanish-adaptation-of-the-2016-european-guidelines-on-cardiovascular-disease-prevention-in-clinical-practice
#8
Miguel Angel Royo-Bordonada, Pedro Armario, José María Lobos Bejarano, Juan Pedro-Botet, Fernando Villar Álvarez, Roberto Elosua, Carlos Brotons Cuixart, Olga Cortés, Benilde Serrano, Miguel Camafort Babkowski, Antonio Gil Núñez, Antonio Pérez, Antonio Maiques, Ana de Santiago Nocito, Almudena Castro, Eduardo Alegría, Ciro Baeza, María Herranz, Susana Sans, Pilar Campos
The VI European Guidelines for Cardiovascular Prevention recommend combining population and high-risk strategies with lifestyle changes as a cornerstone of prevention, and propose the SCORE function to quantify cardiovascular risk. The guidelines highlight disease specific interventions, and conditions as women, young people and ethnic minorities. Screening for subclinical atherosclerosis with noninvasive imaging techniques is not recommended. The guidelines distinguish four risk levels (very high, high, moderate and low) with therapeutic objectives for lipid control according to risk...
November 24, 2016: Revista Española de Salud Pública
https://www.readbyqxmd.com/read/27875557/socioeconomic-status-and-poor-health-outcome-at-10-years-of-follow-up-in-the-multi-ethnic-study-of-atherosclerosis
#9
Steven Shea, Joao Lima, Ana Diez-Roux, Neal W Jorgensen, Robyn L McClelland
BACKGROUND/OBJECTIVES: Predictors of healthy aging have not been well-studied using longitudinal data with demographic, clinical, subclinical, and genetic information. The objective was to identify predictors of poor health outcome at 10 years of follow-up in the Multi-Ethnic Study of Atherosclerosis (MESA). DESIGN: Prospective cohort study. SETTING: Population-based sample from 6 U.S. communities. PARTICIPANTS: 4,355 participants In the MESA Study...
2016: PloS One
https://www.readbyqxmd.com/read/27867269/platyphylloside-isolated-from-betula-platyphylla-inhibit-adipocyte-differentiation-and-induce-lipolysis-via-regulating-adipokines-including-ppar%C3%AE-in-3t3-l1-cells
#10
Mina Lee, Sang Hyun Sung
BACKGROUND: Obesity causes or aggravates many health problems, both independently and in association with several pathological disorders, including Type II diabetes, hypertension, atherosclerosis, and cancer. Therefore, we screened small compounds isolated from natural products for the development of anti-obesity drugs. OBJECTIVE: The purpose of this study was to investigate the anti-adipogenic activities of platyphylloside, diarylheptanoid isolated from Betula platyphylla, which was selected based on the screening using 3T3-L1 cells...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27865565/-ankle-brachial-index-screening-for-peripheral-artery-disease-in-high-cardiovascular-risk-patients-prospective-observational-study-of-370-asymptomatic-patients-at-high-cardiovascular-risk
#11
C Rada, S Oummou, F Merzouk, B Amarir, G Boussabnia, H Bougrini, D Benzaroual, S Elkarimi, M Elhattaoui
INTRODUCTION: Peripheral arterial disease is a marker of systemic atherosclerosis; it is associated with a high risk of cardiovascular disease. The aim of our study was to assess the prevalence of peripheral arterial disease by measuring the ankle-brachial pressure index in patients at high cardiovascular risk and to study the risk factors associated with this disease. METHODOLOGY: This was a descriptive and analytic cross-sectional study which focused on 370 patients seen at the medical consultation for atherosclerosis prevention...
November 16, 2016: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/27864799/primordial-prevention-of-cardiometabolic-risk-in-childhood
#12
Meryem A Tanrikulu, Mehmet Agirbasli, Gerald Berenson
Fetal life and childhood are important in the development of cardiometabolic risk and later clinical disease of atherosclerosis, hypertension and diabetes mellitus. Molecular and environmental conditions leading to cardiometabolic risk in early life bring us a challenge to develop effective prevention and intervention strategies to reduce cardiovascular (CV) risk in children and later disease. It is important that prevention strategies begin at an early age to reduce future CV morbidity and mortality. Pioneering work from longitudinal studies such as Bogalusa Heart Study (BHS), the Finnish Youth Study and other programs provide an awareness of the need for public and health services to begin primordial prevention...
November 19, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27864166/perivascular-adipose-tissue-inflammation-and-coronary-artery-disease-an-autopsy-study-protocol
#13
Daniela Souza Farias-Itao, Carlos Augusto Pasqualucci, Aline Nishizawa, Luiz Fernando Ferraz Silva, Fernanda Marinho Campos, Karen Cristina Souza da Silva, Renata Elaine Paraizo Leite, Lea Tenenholz Grinberg, Renata Eloah Lucena Ferretti-Rebustini, Wilson Jacob Filho, Claudia Kimie Suemoto
BACKGROUND: Perivascular adipose tissue (PAT) inflammation may have a role in coronary artery disease (CAD) pathophysiology. However, most evidence has come from samples obtained during surgical procedures that may imply in some limitations. Moreover, the role of B lymphocytes and inflammation in PAT that is adjacent to unstable atheroma plaques has not been investigated in humans using morphometric measurements. OBJECTIVE: The objective of this study is to investigate the inflammation in PAT, subcutaneous, and perirenal adipose tissues (SAT and PrAT) among chronic CAD, acute CAD, and control groups in an autopsy study...
November 18, 2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27863895/paraoxonase-1-q192r-gene-polymorphism-coronary-heart-disease-and-the-risk-of-a-new-acute-coronary-event
#14
Efrén Martínez-Quintana, Fayna Rodríguez-González, José María Medina-Gil, Paloma Garay-Sánchez, Antonio Tugores
INTRODUCTION: Paraoxonase 1 (PON1) plays a major role in the oxidation of low density lipoprotein and in the prevention of coronary atherogenesis. In this context, coding region polymorphisms of PON1 gene, responsible for the enzyme activity, has become of interest as a marker for atherogenesis. METHODS: A study and follow-up was conducted on 529 patients with an acute coronary event in order to assess the association between the PON1 Q192R (rs662;A/G) polymorphism, the type of acute coronary syndrome, cardiovascular risk factors (arterial hypertension, diabetes mellitus, dyslipidaemia, and smoking), the extent and severity of coronary atherosclerosis, and the medium-term clinical follow-up...
November 15, 2016: Clínica e Investigación en Arteriosclerosis
https://www.readbyqxmd.com/read/27855608/peroxisome-proliferator-activated-receptor-ppar-gamma-agonists-as-therapeutic-agents-for-cardiovascular-disorders-focus-on-atherosclerosis
#15
Ekaterina A Ivanova, Veronika A Myasoedova, Alexandra A Melnichenko, Alexander N Orekhov
Peroxisome proliferation-activated receptors (PPARs) are ligand-activated transcription factors that mainly regulate genes responsible for fatty acid (FA) and energy metabolism. There are three members of the PPAR family, PPAR-α, PPAR- β/δ and PPAR-γ. All three isoforms have therapeutic potential for treatment of cardiovascular disorders, and PPAR agonists are currently being actively studied in pre-clinical and clinical trials. PPAR γ agonists, main tissue expressing isoform, have potential to influence on inflammation processes, reduce oxidative stress, improve endothelial function and plays an important role in lipid metabolism...
November 18, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27852512/the-association-of-secondhand-tobacco-smoke-and-ct-angiography-verified-coronary-atherosclerosis
#16
David F Yankelevitz, Matthew D Cham, Harvey Hecht, Rowena Yip, Joseph Shemesh, Jagat Narula, Claudia I Henschke
OBJECTIVES: The aim of this study was to assess the relationship of the extent of atherosclerosis on coronary computed tomographic angiography to the extent of secondhand tobacco smoke (SHTS) exposure in asymptomatic never smokers. BACKGROUND: A dose-related association between SHTS and coronary artery calcium has been reported, but the total extent of atherosclerosis has not been investigated. METHODS: Two hundred sixty-eight never smokers, ages 40 to 80 years, completed a questionnaire assessing risk factors and extent of lifetime SHTS exposure, providing a total SHTS exposure score...
November 5, 2016: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27847807/comorbidity-in-adult-patients-hospitalized-with-type-2-diabetes-in-northeast-china-an-analysis-of-hospital-discharge-data-from-2002-to-2013
#17
Hui Chen, Yaoyun Zhang, Di Wu, Chunxiu Gong, Qing Pan, Xiao Dong, Yonghui Wu, Kuan Zhang, Shiping Wang, Jianbo Lei, Hua Xu
This study aims to evaluate the comorbidity burden and patterns among adult patients hospitalized with a diagnosis of type 2 diabetes mellitus (T2DM) in Northeast China using hospital discharge data derived from the electronic medical record database between 2002 and 2013. 12.8% of 4,400,892 inpatients aged ≥18 had a diagnosis of T2DM. Sex differences in prevalence varied among those aged <50, 50-59, and ≥60. Twenty-seven diseases were determined as major comorbidities of T2DM. Essential hypertension was the most common comorbidity of T2DM (absolute cooccurrence risk, 58...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27835743/a-low-ankle-brachial-index-is-associated-with-cognitive-impairment-the-apac-study
#18
Anxin Wang, Ruixuan Jiang, Zhaoping Su, Jiaokun Jia, Ning Zhang, Jianwei Wu, Shengyun Chen, Xingquan Zhao
BACKGROUND AND AIMS: Given the recognized links between atherosclerosis and cognitive impairment, the aim of this study was to examine the association between the ankle-brachial index (ABI) and cognitive impairment in a cross-sectional setting of a Chinese population. METHODS: Participants (n = 3,048, aged ≥40 years, 1727 men and 1321 women) were recruited from the ongoing community-based Asymptomatic Polyvascular Abnormalities Community Study. ABI was measured and a low ABI was defined as <0...
November 3, 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27833720/life-psychosocial-stresses-and-coronary-artery-disease
#19
Babak Bagheri, Fatemeh Meshkini, Kolsoum Dinarvand, Zahra Alikhani, Mal Haysom, Mehdi Rasouli
BACKGROUND: It is hypothesized that the impacts of life events accumulate and can trigger and promote atherosclerosis in susceptible individuals. In the current study, the correlation of total life stressors during 1 year was investigated relative to coronary artery disease (CAD). METHODS: The study population consisted of 148 males and 152 females aged 35-76 years. The subjects were classified as CAD cases and controls according to the results of coronary angiography...
2016: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/27829989/progress-and-prospect-of-mesenchymal-stem-cell-based-therapy-in-atherosclerosis
#20
REVIEW
Ximei Zhang, Feng Huang, Yanming Chen, Xiaoxian Qian, Song Guo Zheng
Atherosclerosis is a chronic inflammatory disease of the arterial intima, occurring usually in the aged populations who are suffering from hypertension, dyslipidemia and diabetes for a long time. Research on atherosclerosis has shown that macrophage foam cell formation, inflammation, dyslipidemia and immune cells infiltration are all involved in regulating the onset and progression of atherosclerosis. Mesenchymal stem cells (MSCs) originated from different kinds of tissue are a group of cells possessing well-established self-renewal and multipotent differentiation properties as well as immunomodulatory and anti-inflammatory roles...
2016: American Journal of Translational Research
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