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https://www.readbyqxmd.com/read/28334718/sex-differences-do-not-exist-in-outcomes-among-stroke-patients-with-intracranial-atherosclerosis-in-china-subgroup-analysis-from-the-chinese-intracranial-atherosclerosis-study
#1
Yuehua Pu, Na Wei, Dandan Yu, Yilong Wang, Xinying Zou, Yannie O Y Soo, Yuesong Pan, Thomas W H Leung, Lawrence K S Wong, Yongjun Wang, Liping Liu
BACKGROUND: To date, sex difference in outcomes among patients with intracranial atherosclerosis (ICAS) has rarely been discussed in China as well as in the world. This study aimed to estimate the sex difference in outcomes among patients with ICAS in Chinese cerebral ischemia patients. METHODS: We analyzed 1,335 men and women with ICAS who were enrolled in the Chinese Intracranial Atherosclerosis study. They were followed-up for ischemic stroke recurrence, any cause of death, cerebral vascular events (including transient ischemic attack, ischemic and hemorrhagic stroke), combined end points (including cerebral vascular events, angina or myocardial infarction, pulmonary embolism, peripheral vascular events), and unfavorable outcome (modified Rankin scale score of 3-6) at 1 year...
March 24, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/28332240/lower-urinary-tract-symptoms-benign-prostatic-hypertrophy-and-vascular-function-role-of-the-nitric-oxide-phosphodiesterase-type-5-cyclic-guanosine-3-5-monophosphate-pathway
#2
REVIEW
Yukihito Higashi
It is well known that there is an association of lower urinary tract symptoms/benign prostatic hypertrophy with cardiovascular disease, suggesting that lower urinary tract symptoms/benign prostatic hypertrophy is a risk factor for cardiovascular events. Vascular function, including endothelial function and vascular smooth muscle function, is involved in the pathogenesis, maintenance and development of atherosclerosis, leading to cardiovascular events. Vascular dysfunction per se should also contribute to lower urinary tract symptoms/benign prostatic hypertrophy...
March 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28314892/abnormal-kynurenine-pathway-of-tryptophan-catabolism-in-cardiovascular-diseases
#3
REVIEW
Ping Song, Tharmarajan Ramprasath, Huan Wang, Ming-Hui Zou
Kynurenine pathway (KP) is the primary path of tryptophan (Trp) catabolism in most mammalian cells. The KP generates several bioactive catabolites, such as kynurenine (Kyn), kynurenic acid (KA), 3-hydroxykynurenine (3-HK), xanthurenic acid (XA), and 3-hydroxyanthranilic acid (3-HAA). Increased catabolite concentrations in serum are associated with several cardiovascular diseases (CVD), including heart disease, atherosclerosis, and endothelial dysfunction, as well as their risk factors, including hypertension, diabetes, obesity, and aging...
March 17, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28306170/impact-of-atrial-fibrillation-on-platelet-gene-expression
#4
Waldemar E Wysokinski, Alfonso Tafur, Naser Ammash, Samuel J Asirvatham, Yanhong Wu, Izabella Gosk-Bierska, Diane E Grill, Joshua P Slusser, Jozef Mruk, Robert D McBane
AIMS: Platelets retain cytoplasmic messenger RNA and are capable of protein biosynthesis. Several diseases are known to impact the platelet transcriptome but the effect of non-valvular atrial fibrillation (NVAF) on platelet RNA transcript is essentially unknown. The aim of this study was to evaluate the impact of NVAF on platelet RNA transcript by measuring platelet genes expression in consecutive NVAF patients before and 3-4 months after pulmonary vein isolation (PVI) and compared to normal sinus rhythm controls (NSR)...
March 17, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28300335/risk-factors-for-cardiovascular-disease-in-patients-with-hidradenitis-suppurativa
#5
Caroline Vinkel, Simon Francis Thomsen
We read with great interest the article by Pascual et al., in which subclinical atherosclerosis in patients with hidradenitis suppurativa (HS) was assessed using carotid ultrasound. They found a higher prevalence of subclinical atherosclerosis in HS patients (30.7%) compared with controls (16.1%) and the association was significant in patients 40 years and older. Furthermore, traditional cardiovascular (CV) risk factors like hypertension (41.9%), diabetes mellitus (22.6%), and metabolic syndrome (38.7%) along with elevated systemic inflammatory markers including high-sensitivity C-reactive protein (Hs-CRP) (61...
March 16, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28299634/prevalence-and-determinants-of-the-use-of-lipid-lowering-agents-in-a-population-of-older-hospitalized-patients-the-findings-from-the-reposi-registro-politerapie-societ%C3%A3-italiana-di-medicina-interna-study
#6
Marco Bertolotti, Carlotta Franchi, Marco B L Rocchi, Andrea Miceli, M Vittoria Libbra, Alessandro Nobili, Giulia Lancellotti, Lucia Carulli, Chiara Mussi
BACKGROUND: Older patients are prone to multimorbidity and polypharmacy, with an inherent risk of adverse events and drug interactions. To the best of our knowledge, available information on the appropriateness of lipid-lowering treatment is extremely limited. AIM: The aim of the present study was to quantify and characterize lipid-lowering drug use in a population of complex in-hospital older patients. METHODS: We analyzed data from 87 units of internal medicine or geriatric medicine in the REPOSI (Registro Politerapie della Società Italiana di Medicina Interna) study, with reference to the 2010 and 2012 patient cohorts...
April 2017: Drugs & Aging
https://www.readbyqxmd.com/read/28298268/effects-of-dietary-flavonoids-on-reverse-cholesterol-transport-hdl-metabolism-and-hdl-function
#7
REVIEW
Courtney L Millar, Quinn Duclos, Christopher N Blesso
Strong experimental evidence confirms that HDL directly alleviates atherosclerosis. HDL particles display diverse atheroprotective functions in reverse cholesterol transport (RCT), antioxidant, anti-inflammatory, and antiapoptotic processes. In certain inflammatory disease states, however, HDL particles may become dysfunctional and proatherogenic. Flavonoids show the potential to improve HDL function through their well-documented effects on cellular antioxidant status and inflammation. The aim of this review is to summarize the basic science and clinical research examining the effects of dietary flavonoids on RCT and HDL function...
March 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28295858/non-obstructive-carotid-atherosclerosis-and-patent-foramen-ovale-in-young-adults-with-cryptogenic-stroke
#8
A Jaffre, B Guidolin, J-B Ruidavets, N Nasr, V Larrue
BACKGROUND AND PURPOSE: Up to 50% of ischaemic strokes in young adults are classified as cryptogenic despite extensive work-up. We sought to evaluate the prevalence of non-obstructive carotid atherosclerosis (NOCA) and its association with patent foramen ovale (PFO) in young adults with cryptogenic stroke (CS). METHODS: Patients aged 18-54 years, consecutively treated for first-ever CS in an academic stroke service, were included. NOCA was assessed using carotid ultrasound examination and was defined as carotid plaque with <50% stenosis...
March 15, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28292529/-spanish-adaptation-of-the-2016-european-guidelines-on-cardiovascular-disease-prevention-in-clinical-practice
#9
M Á Royo-Bordonada, P Armario, J M Lobos Bejarano, J Pedro-Botet, F Villar Alvarez, R Elosua, C Brotons Cuixart, O Cortés, B Serrano, M Camafort Babkowski, A Gil Núñez, A Pérez, A Maiques, A de Santiago Nocito, A Castro, E Alegría, C Baeza, M Herranz, S Sans, P Campos
The VI European Guidelines for Cardiovascular Prevention recommend combining population and high-risk strategies with lifestyle changes as a cornerstone of prevention, and propose the SCORE function to quantify cardiovascular risk. The guidelines highlight disease specific interventions, and conditions as women, young people and ethnic minorities. Screening for subclinical atherosclerosis with noninvasive imaging techniques is not recommended. The guidelines distinguish four risk levels (very high, high, moderate and low) with therapeutic objectives for lipid control according to risk...
March 11, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28291548/the-role-of-interleukin-17a-in-the-pathogenesis-of-kidney-diseases
#10
REVIEW
Charlotte Cortvrindt, Reinhart Speeckaert, Alena Moerman, Joris R Delanghe, Marijn M Speeckaert
Being a member of the IL-17 family, comprising six structurally related ligands, IL-17A is a cytokine, produced by multiple cell types, such as CD4(+)αβ T cells, γδ T cells, natural killer cells, neutrophils, macrophages, dendritic cells, lymphoid tissue inducer cells, mast cells and plasma cells. IL-17A participates in tissue inflammation by inducing the expression of chemokines, proinflammatory cytokines and matrix metalloproteases. Besides its role in host defence against infectious diseases, IL-17A is involved in different autoimmune and inflammatory diseases...
March 10, 2017: Pathology
https://www.readbyqxmd.com/read/28291054/progression-of-atherosclerosis-in-hiv-infected-individuals-prospective-data-from-an-asian-cohort
#11
Grace Lui, Ronald Cw Ma, Ping Chook, Chun-Kwok Wong, Claudia Ht Tam, Michael Hm Chan, Shui-Shan Lee, Rity Yk Wong, Catherine Sk Cheung, Kin-Wing Choi, Ping-Chung Leung, Ka-Hing Wong, Kenny Cw Chan, Nelson Lee
BACKGROUND: The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1) the rate of progression of atherosclerosis in HIV-infected individuals, and (2) metabolic and inflammatory parameters that may predict atherosclerosis progression in HIV-infected individuals in an Asian cohort. SETTING: A prospective, longitudinal study was performed among adults attending an HIV Metabolic clinic in Hong Kong...
March 10, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28290390/prevalence-and-risk-factors-of-asymptomatic-carotid-artery-stenosis-in-indian-population-an-8-year-follow-up-study
#12
Subhash Kaul, Suvarna Alladi, K Rukmini Mridula, V C S Srinivasarao Bandaru, Matapathi Umamashesh, Darapureddy Anjanikumar, Palli Lalitha, R Chandrasekhar
BACKGROUND: Asymptomatic carotid artery stenosis (ACAS) is a marker for cerebrovascular disease, coronary atherosclerosis, and death. AIM: To investigate the prevalence of ACAS in the Indian population, and to correlate ACAS with other vascular risk factors. MATERIALS AND METHODS: We prospectively recruited 1500 individuals who were older than 40 years and asymptomatic for cerebrovascular disease between June 2003 and December 2014. Evaluation of vascular risk factors was done for all the participants...
March 2017: Neurology India
https://www.readbyqxmd.com/read/28289532/association-between-high-cystatin-c-levels-and-carotid-atherosclerosis
#13
Toshiyuki Kobayashi, Hirohide Yokokawa, Kazutoshi Fujibayashi, Tomomi Haniu, Teruhiko Hisaoka, Hiroshi Fukuda, Toshio Naito
AIM: To investigate the association between carotid atherosclerosis and cystatin C (CysC) and to determine the optimal CysC cut-off value. METHODS: One hundred twenty-eight subjects were included in this study. Atherosclerosis was defined as a maximum carotid plaque thickness (MCPT) of greater than 2 mm. A receiver operating characteristic curve analysis was used to determine the diagnostic value of serum CysC for atherosclerosis. The subjects were divided into two groups according to the CysC cut-off value...
February 26, 2017: World Journal of Cardiology
https://www.readbyqxmd.com/read/28289478/cerebral-white-matter-hyperintensities-on-mri-and-acceleration-of-epigenetic-aging-the-atherosclerosis-risk-in-communities-study
#14
Abhay Raina, Xiaoping Zhao, Megan L Grove, Jan Bressler, Rebecca F Gottesman, Weihua Guan, James S Pankow, Eric Boerwinkle, Thomas H Mosley, Myriam Fornage
BACKGROUND: Cerebral white matter hyperintensities (WMH) on magnetic resonance imaging (MRI) are part of the spectrum of brain vascular injury accompanying aging and are associated with a substantial risk of stroke and dementia. We investigated the association of cerebral WMH burden on MRI with a DNA methylation-based biomarker of aging, termed DNA methylation age acceleration, which represents the deviation of the DNA methylation-predicted age from the chronologic age. RESULTS: In this cross-sectional observational study of 713 African-American participants of the Atherosclerosis Risk in Communities study, aged 51-73 years, estimates of predicted age were obtained based on two algorithms (Hannum et al...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28285092/visceral-to-subcutaneous-fat-ratio-is-independently-related-to-small-and-large-cerebrovascular-lesions-even-in-healthy-subjects
#15
Satoshi Higuchi, Yusuke Kabeya, Kiyoe Kato
BACKGROUND AND AIMS: The severity of obesity is evaluated by visceral-to-subcutaneous fat ratio (VS ratio), which may be useful for predicting atherosclerosis. However, it is unclear how VS ratio affects different types of cerebrovascular lesions. This study was conducted to evaluate the clinical impact of visceral fat accumulation on the cerebrovascular lesions. METHODS: This cross-sectional study included 980 apparently healthy Japanese adults who underwent a health check-up program focused toward atherosclerosis, between 2011 and 2014...
March 2, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28281456/insulin-resistance-in-systemic-lupus-erythematosus-patients-contributing-factors-and-relationship-with-subclinical-atherosclerosis
#16
Hiurma Sánchez-Pérez, Beatriz Tejera-Segura, Antonia de Vera-González, Alejandra González-Delgado, José Manuel Olmos, José Luis Hernández, Alfonso Corrales, Raquel López-Mejías, Miguel Angel González-Gay, Iván Ferraz-Amaro
OBJECTIVES: Insulin resistance (IR) plays a role in the increased cardiovascular risk of systemic lupus erythematosus (SLE) patients. This study aimed to determine the potential association of IR with disease activity, drug exposure and subclinical atherosclerosis in patients with SLE. METHODS: This cross-sectional study encompassed 87 non-diabetic SLE patients and 82 sex-matched controls. Insulin and C-peptide serum levels, IR indexes by homeostatic model assessment (HOMA2) (both insulin-based: HOMA2-IR, and with C-peptide: HOMA2-IR-C-peptide) and lipid profiles were assessed in patients and controls...
March 8, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28273932/hepatocyte-growth-factor-prevented-high-fat-diet-induced-obesity-and-improved-insulin-resistance-in-mice
#17
Jun Muratsu, Masaaki Iwabayashi, Fumihiro Sanada, Yoshiaki Taniyama, Rei Otsu, Hiromi Rakugi, Ryuichi Morishita
Obesity and its associated chronic inflammation in adipose tissue initiate insulin resistance, which is related to several pathologies including hypertension and atherosclerosis. Previous reports demonstrated that circulating hepatocyte growth factor (HGF) level was associated with obesity and type 2 diabetes. However, its precise role in obesity and related-pathology is unclear. In this experiment, cardiac-specific over-expression of human HGF in mice (HGF-Tg mice) which showed 4-5 times higher serum HGF levels than wild-type mice were used...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28272814/the-relationship-between-cardio-ankle-vascular-index-and-subclinical-atherosclerosis-evaluated-by-cardiac-computed-tomographic-angiography
#18
Suguru Matsumoto, Rine Nakanishi, Yanting Luo, Michael Kim, Anas Alani, Negin Nezarat, Christopher Dailing, Matthew J Budoff
BACKGROUND: The cardio-ankle vascular index (CAVI) is a new noninvasive index to evaluate arterial stiffness. We investigated whether CAVI can predict severity, extent, and burden of coronary artery disease by comparing results with cardiac computed tomographic angiography (CCTA). HYPOTHESIS: CAVI may predict the presence of subclinical atherosclerosis. METHODS: We prospectively enrolled 95 patients (66% male; mean age, 50 ± 16 years) who underwent both CCTA and CAVI consecutively...
March 8, 2017: Clinical Cardiology
https://www.readbyqxmd.com/read/28270891/visit-to-visit-low-density-lipoprotein-cholesterol-variability-is-an-independent-determinant-of-carotid-intima-media-thickness-in-patients-with-type-2-diabetes
#19
Akiko Takenouchi, Ayaka Tsuboi, Kaori Kitaoka, Satomi Minato, Miki Kurata, Keisuke Fukuo, Tsutomu Kazumi
BACKGROUND: Studies demonstrated that visit-to-visit variability in low-density lipoprotein cholesterol (LDLC) is an independent predictor of cardiovascular events in subjects with coronary artery disease. Whether visit-to-visit variability in LDLC levels affects subclinical atherosclerosis is unknown. This study sought to evaluate the role of visit-to-visit variability in LDLC levels on subclinical atherosclerosis. METHODS: We evaluated 162 type 2 diabetic patients with measurement of carotid intima-media thickness (IMT)...
April 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28262189/hypercholesterolemia-as-a-risk-factor-for-cardiovascular-disease-current-controversial-therapeutic-management
#20
REVIEW
Arturo Zárate, Leticia Manuel-Apolinar, Renata Saucedo, Marcelino Hernández-Valencia, Lourdes Basurto
Cholesterol is a precursor of steroid hormones and an essential component of the cell membrane; however, altered regulation of the synthesis, absorption and excretion of cholesterol predispose to cardiovascular diseases of atherosclerotic origin. Despite the recognition of historical events for 200 years starting with Chevreul naming "cholesterine"; later on, Lobstein coining the term atherosclerosis and Marchand introducing it, Anichkov identifying cholesterol in atheromatous plaque, and Brown and Goldstein discovering LDL receptor (r-LDL), as well as the emergence of different drugs such as fibrates, statins and cetrapibs during this decade promising to increase HDL, and the most recent, ezetimibe and anti-PCSK9 to inhibit the degradation of r-LDL, morbidity has not been reduced in cardiovascular disease...
October 2016: Archives of Medical Research
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