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JOURNAL ARTICLE
Alfred S Y Lee, Jesus Alfonso Daep Datu, Kevin Kien Hoa Chung, Wing Kai Fung, Ryan Yat Ming Cheung
The present research examined the effects of an Early Advancement in Social-Emotional Health and Positivity (EASP) multicomponent positive psychological intervention on parents' well-being in Hong Kong. Participants were parents of young children (N = 120; Mage = 37.19 years, SD = 4.71, range = 24-53; female = 95.00%) who participated in the one-month randomized control trial. Participants were randomly assigned into the intervention (n = 50) and waitlist control groups (n = 70)...
February 28, 2024: Family Process
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JOURNAL ARTICLE
Runguo Wu, Claire Williams, Junwen Zhou, Iryna Schlackow, Jonathan Emberson, Christina Reith, Anthony Keech, John Robson, Jane Armitage, Alastair Gray, John Simes, Colin Baigent, Borislava Mihaylova, Jane Armitage, Colin Baigent, Elizabeth Barnes, Lisa Blackwell, Rory Collins, Kelly Davies, Jonathan Emberson, Jordan Fulcher, Heather Halls, William G Herrington, Lisa Holland, Anthony Keech, Adrienne Kirby, Borislava Mihaylova, Rachel O'Connell, David Preiss, Christina Reith, John Simes, Kate Wilson, Michael Blazing, Eugene Braunwald, James de Lemos, Sabina Murphy, Terje R Pedersen, Marc Pfeffer, Harvey White, Stephen Wiviott, Michael Clearfield, John R Downs, Antonio Gotto, Stephen Weis, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Terje R Pedersen, David Gordon, Barry Davis, Curt Furberg, Richard Grimm, Sara Pressel, Jeffrey L Probstfield, Mahboob Rahman, Lara Simpson, Michael Koren, Björn Dahlöf, Ajay Gupta, Neil Poulter, Peter Sever, Hans Wedel, Robert H Knopp, Stuart Cobbe, Bengt Fellström, Hallvard Holdaas, Alan Jardine, Roland Schmieder, Faiez Zannad, D John Betteridge, Helen M Colhoun, Paul N Durrington, John Fuller, Graham A Hitman, Andrew Neil, Eugene Braunwald, Barry Davis, C Morton Hawkins, Lemuel Moyé, Marc Pfeffer, Frank Sacks, John Kjekshus, Hans Wedel, John Wikstrand, Christoph Wanner, Vera Krane, Maria Grazia Franzosi, Roberto Latini, Donata Lucci, Aldo Maggioni, Roberto Marchioli, Enrico B Nicolis, Luigi Tavazzi, Gianni Tognoni, Jackie Bosch, Eva Lonn, Salim Yusuf, Jane Armitage, Louise Bowman, Rory Collins, Anthony Keech, Martin Landray, Sarah Parish, Richard Peto, Peter Sleight, John Jp Kastelein, Terje R Pedersen, Robert Glynn, Antonio Gotto, John Jp Kastelein, Wolfgang Koenig, Jean MacFadyen, Paul M Ridker, Anthony Keech, Stephen MacMahon, Ian Marschner, Andrew Tonkin, John Shaw, John Simes, Harvey White, Patrick W Serruys, Genell Knatterud, Gerard J Blauw, Stuart Cobbe, Ian Ford, Peter Macfarlane, Chris Packard, Naveed Sattar, James Shepherd, Stella Trompet, Eugene Braunwald, Christopher P Cannon, Sabina Murphy, Rory Collins, Jane Armitage, Louise Bowman, Richard Bulbulia, Richard Haynes, Sarah Parish, Richard Peto, Peter Sleight, Pierre Amarenco, K Michael Welch, John Kjekshus, Terje R Pedersen, Lars Wilhelmsen, Philip Barter, Antonio Gotto, John LaRosa, John Jp Kastelein, James Shepherd, Stuart Cobbe, Ian Ford, Sharon Kean, Peter Macfarlane, Chris Packard, Michele Roberston, Naveed Sattar, James Shepherd, Robin Young, Hiroyuki Arashi, Robert Clarke, Marcus Flather, Shinya Goto, Uri Goldbourt, Jemma Hopewell, G Kees Hovingh, George Kitas, Connie Newman, Marc S Sabatine, Gregory G Schwartz, Liam Smeeth, Jonathan Tobert, John Varigos, Junichi Yamamguchi
BACKGROUND: UK cardiovascular disease (CVD) incidence and mortality have declined in recent decades but socioeconomic inequalities persist. AIM: To present a new CVD model, and project health outcomes and the impact of guideline-recommended statin treatment across quintiles of socioeconomic deprivation in the UK. DESIGN AND SETTING: A lifetime microsimulation model was developed using 117 896 participants in 16 statin trials, 501 854 UK Biobank (UKB) participants, and quality-of-life data from national health surveys...
February 19, 2024: British Journal of General Practice
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JOURNAL ARTICLE
Xiaoqiu Li, Zhenni Guo, Lu Wang, Yue Wang, Thanh Nguyen, Yi Yang, Hui-Sheng Chen
RATIONALE: The effect of the head position as a non-pharmacological therapy on acute ischaemic stroke (AIS) remains inconclusive. Our recent Head dOwn-Position for acutE moderate ischaemic Stroke with large artery atherosclerosis (HOPES 2) suggested the safety, feasibility and potential benefit of the head-down position (HDP) in AIS. AIM: To investigate the benefit of HDP in acute moderate ischaemic stroke patients with large artery atherosclerosis (LAA). SAMPLE SIZE ESTIMATES: Based on a two-sided 0...
January 31, 2024: Stroke and Vascular Neurology
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JOURNAL ARTICLE
Laura Sherlock, Shun Fu Lee, Aristeidis H Katsanos, Tali Cukierman-Yaffe, Michelle Canavan, Raed Joundi, Mukul Sharma, Ashkan Shoamanesh, Carol Brayne, Hertzel C Gerstein, Martin J O'Donnell, Graciela Muniz-Terrera, Salim Yusuf, Jackie Bosch, William N Whiteley
BACKGROUND: Survivors of stroke are often concerned about cognitive problems, and information on the risk of cognitive problems often comes from small studies. We aimed to estimate years of cognitive ageing associated with stroke compared with transient ischaemic attack, myocardial infarction, and other hospitalisations in a large population. METHODS: Using data from six randomised controlled trials (ORIGIN, ONTARGET, TRANSCEND, COMPASS, HOPE-3, and NAVIGATE ESUS), we completed an individual participant data meta-analysis using data requested from the Public Health Research Institute to estimate the association of stroke (by type and severity), transient ischaemic attack, myocardial infarction, and other hospitalisations with cognitive performance measured at the end of each trial...
December 2023: The Lancet. Healthy longevity
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JOURNAL ARTICLE
Masoume Rambod, Nilofar Pasyar, Ali Mohammad Parviniannasab
BACKGROUND: End Stage Renal Disease (ESRD) patients undergoing hemodialysis are faced with serious problems in their lives. Hope, as a multifaceted factor, plays a critical role in these patients' lives. Given the multifaceted process of hope, this study aimed to describe hope and identify the challenges, strategies, and outcomes of hope in Iranian ESRD patients undergoing hemodialysis. METHODS: This is a qualitative study using content analysis. The participants were selected using purposive sampling...
September 22, 2023: BMC Nephrology
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JOURNAL ARTICLE
Erica Sood, Shannon N Nees, Shubhika Srivastava, Stephanie Ng, Cynthia Torres, Angel Munoz Osorio, Kimberly S Canter, Katherine T Braley, Lisa Spradley, Jennifer Stein, Erin Riegel, Anne E Kazak
Prenatal diagnosis of congenital heart disease (CHD) often leads to anxiety, depression, and traumatic stress in expectant mothers, with long-term implications for the child and family. However, psychosocial intervention is rarely incorporated into prenatal care. HEARTPrep is a virtually delivered psychosocial intervention aimed at reducing distress and social isolation and increasing parenting self-efficacy and hope for mothers expecting a baby with CHD to promote long-term child/family well-being. This study evaluated the feasibility and acceptability of HEARTPrep...
June 24, 2023: Pediatric Cardiology
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JOURNAL ARTICLE
James Rujimora, Anna Swygert, Andrew Walker, Zachary McNiece, Eunhui Yoon, Mercedes Machado, Kenneth Myers, Eric Richardson, Emilie Lenes, Lindsay Hebert, Emily Marchi, Zoe Arthurson-McColl, Joanne Lagmay, Ana Puig
Background: The pediatric palliative care literature provides little evidence regarding the lived experiences of adolescents and young adults (AYAs). Objectives: We sought to evaluate the aspects of a palliative care peer support program, which were most helpful to patients, and identify areas for improvement to better address their psychosocial needs. Design: This was a retrospective, cross-sectional study, which described self-reported Streetlight program evaluation using thematic analysis of interviews with AYAs...
September 2023: Journal of Palliative Medicine
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JOURNAL ARTICLE
Gilles R Dagenais, Prem Pais, Peggy Gao, Gholamreza Roshandel, Reza Malekzadeh, Philip Joseph, Salim Yusuf
OBJECTIVE: To evaluate the effects of fixed dose combination (FDC) medications on cardiovascular outcomes in different age groups in an individual participant meta-analysis of three primary prevention randomised trials. METHODS: Participants at intermediate risk (17.7% mean 10-year Framingham Cardiovascular Risk Score), randomised to FDC of two or more antihypertensives and a statin with or without aspirin, or to their respective control, were followed up for 5 years...
August 24, 2023: Heart
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REVIEW
Fernando Botto, Carlos Tajer, Rafael Díaz, Daniel Piñeiro, Álvaro Sosa Liprandi
Unlike medications that contain fixed-dose combinations, such as those recommended by clinical guidelines for treating high blood pressure, the so-called polypills contain several drugs that simultaneously treat two or more cardiovascular conditions or risk factors. They were proposed 2 decades ago, both for primary and secondary prevention with the hypothesis that they could have wide dissemination and population penetration, improving the use of therapeutics with proven benefits individually, thanks to an increase in patient adherence by reducing the number of daily tablets and also by having an equal or lower cost...
2022: Medicina
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JOURNAL ARTICLE
Kelcey A Bland, Meinir Krishnasamy, Evelyn B Parr, Stella Mulder, Peter Martin, Luc J C van Loon, Prue Cormie, Natasha Michael, Eva M Zopf
Cachexia is a prevalent muscle wasting syndrome among people with advanced cancer that profoundly impacts patient quality of life (QoL) and physical function. Exercise can improve QoL, physical function, and overall health in people with cancer and may be an important addition to treatment approaches for cancer cachexia. Greater understanding of patients' perception of exercise can help elucidate the feasibility of implementing exercise interventions for cancer cachexia and facilitate the design of patient-centered interventions...
May 17, 2022: BMC Palliative Care
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REVIEW
Daniel E McNavish, Charles A German, Michael D Shapiro
PURPOSE OF REVIEW: To review the milestone trials and recent literature supporting statin therapy for prevention of atherosclerotic cardiovascular disease (ASCVD) and to provide rationale for more generalized use of statin therapy among patients treated for hypertension. RECENT FINDINGS: Hypertension is a leading modifiable risk factor for ASCVD worldwide. Randomized controlled trial evidence supports initiation of antihypertensive medication for stage 2 hypertension regardless of ASCVD risk...
January 24, 2022: Current Hypertension Reports
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JOURNAL ARTICLE
Britt Moene Kuven, Tove Giske
BACKGROUND: The aim of this article is to explore sources of hope for patients by using patients' narratives and perspectives on how they find hope when facing illness. Hope enables people to endure suffering and can be critical to how people cope with illness. Hope is not a singular phenomenon, so nurses need to understand how to support the patients' sources of hope. METHODS: We used a qualitatively descriptive design with qualitative content analysis. We examined reflective notes from 385 first-year nursing students after they had had a conversation with patients with disease experiences following Graneheim and Lundman's description of analysis...
January 17, 2022: Scandinavian Journal of Caring Sciences
#13
JOURNAL ARTICLE
Maayan N Rosenfield, Michael H Bernstein
Objective: To examine how psychiatrists think about and modulate non-specific factors (e.g., hope, expectations) in clinical practice. Methods: U.S. psychiatrists were recruited for two studies assessing attitudes and behaviors related to non-specific factors. Study 1 entailed remote qualitative focus groups ( k = 7) with n = 26 participants (36.0% female). Study 2 was a quantitative survey with n = 346 respondents (34.0% female) designed to assess the generalizability of focus group findings. Results: Four themes were identified in Study 1 that were used to inform the survey (Study 2): (1) Expectations (2) Hope, (3) Placebo Effect, and (4) Aesthetic Features...
2021: Frontiers in Psychiatry
#14
REVIEW
Mila Petrova, Geoff Wong, Isla Kuhn, Ian Wellwood, Stephen Barclay
BACKGROUND: Community-based and home-based palliative and end-of-life care (PEoLC) services, often underpinned by primary care provision, are becoming increasingly popular. One of the key challenges associated with them is their timely initiation. The latter requires an accurate enough prediction of how close to death a patient is. METHODS: Using 'realist synthesis' tools, this review sought to develop explanations of how primary care and community PEoLC programmes generate their outcomes, with the explanations presented as context-mechanism-outcome configurations...
December 9, 2021: BMJ Supportive & Palliative Care
#15
JOURNAL ARTICLE
Philip Joseph, Gholamreza Roshandel, Peggy Gao, Prem Pais, Eva Lonn, Denis Xavier, Alvaro Avezum, Jun Zhu, Lisheng Liu, Karen Sliwa, Habib Gamra, Shrikant I Bangdiwala, Koon Teo, Rafael Diaz, Antonio Dans, Patricio Lopez-Jaramillo, Dorairaj Prabhakaran, Jose Maria Castellano, Valentin Fuster, Anthony Rodgers, Mark D Huffman, Jackie Bosch, Gilles R Dagenais, Reza Malekzadeh, Salim Yusuf
BACKGROUND: In randomised controlled trials, fixed-dose combination treatments (or polypills) have been shown to reduce a composite of cardiovascular disease outcomes in primary prevention. However, whether or not aspirin should be included, effects on specific outcomes, and effects in key subgroups are unknown. METHODS: We did an individual participant data meta-analysis of large randomised controlled trials (each with ≥1000 participants and ≥2 years of follow-up) of a fixed-dose combination treatment strategy versus control in a primary cardiovascular disease prevention population...
September 25, 2021: Lancet
#16
JOURNAL ARTICLE
Nelson Wang, Mark D Huffman, Johan Sundström, Anthony Rodgers
BACKGROUND: We aimed to assess whether the modest major adverse cardiovascular events (MACE) reductions in previous trials testing combined blood pressure (BP) and low density lipoprotein cholesterol (LDL-C) reduction were due to modest risk factor reduction and/or a negative interaction, whereby the joint effects of therapy are less than expected. METHODS: We performed a systematic review of randomized controlled trials comparing patients who received combination BP and cholesterol lowering treatment versus placebo...
August 17, 2021: International Journal of Cardiology
#17
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 2021: Stroke; a Journal of Cerebral Circulation
#18
JOURNAL ARTICLE
Jackie Bosch, Eva M Lonn, Gilles R Dagenais, Peggy Gao, Patricio Lopez-Jaramillo, Jun Zhu, Prem Pais, Alvaro Avezum, Karen Sliwa, Irina E Chazova, Ron J G Peters, Claes Held, Khalid Yusoff, Basil S Lewis, William D Toff, Kamlesh Khunti, Christopher M Reid, Lawrence A Leiter, Salim Yusuf, Robert G Hart
[Figure: see text].
August 2021: Stroke; a Journal of Cerebral Circulation
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RANDOMIZED CONTROLLED TRIAL
Jackie Bosch, Eva M Lonn, Hyejung Jung, Jun Zhu, Lisheng Liu, Patricio Lopez-Jaramillo, Prem Pais, Denis Xavier, Rafael Diaz, Gilles Dagenais, Antonio Dans, Alvaro Avezum, Leopoldo S Piegas, Alexander Parkhomenko, Kati Keltai, Matyas Keltai, Karen Sliwa, Claus Held, Ronald J G Peters, Basil S Lewis, Petr Jansky, Khalid Yusoff, Kamlesh Khunti, William D Toff, Christopher M Reid, John Varigos, Philip Joseph, Lawrence A Leiter, Salim Yusuf
AIMS: Rosuvastatin (10 mg per day) compared with placebo reduced major adverse cardiovascular (CV) events by 24% in 12 705 participants at intermediate CV risk after 5.6 years. There was no benefit of blood pressure (BP) lowering treatment in the overall group, but a reduction in events in the third of participants with elevated systolic BP. After cessation of all the trial medications, we examined whether the benefits observed during the active treatment phase were sustained, enhanced, or attenuated...
August 17, 2021: European Heart Journal
#20
JOURNAL ARTICLE
Eric Boersma, Isabella Kardys
No abstract text is available yet for this article.
May 6, 2021: European Heart Journal
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