Leila B Giron, Qin Liu, Opeyemi S Adeniji, Xiangfan Yin, Toshitha Kannan, Jianyi Ding, David Y Lu, Susan Langan, Jinbing Zhang, Joao L L C Azevedo, Shuk Hang Li, Sergei Shalygin, Parastoo Azadi, David B Hanna, Igho Ofotokun, Jason Lazar, Margaret A Fischl, Sabina Haberlen, Bernard Macatangay, Adaora A Adimora, Beth D Jamieson, Charles Rinaldo, Daniel Merenstein, Nadia R Roan, Olaf Kutsch, Stephen Gange, Steven M Wolinsky, Mallory D Witt, Wendy S Post, Andrew Kossenkov, Alan L Landay, Ian Frank, Phyllis C Tien, Robert Gross, Todd T Brown, Mohamed Abdel-Mohsen
People living with HIV (PLWH) experience increased vulnerability to premature aging and inflammation-associated comorbidities, even when HIV replication is suppressed by antiretroviral therapy (ART). However, the factors associated with this vulnerability remain uncertain. In the general population, alterations in the N-glycans on IgGs trigger inflammation and precede the onset of aging-associated diseases. Here, we investigate the IgG N-glycans in cross-sectional and longitudinal samples from 1214 women and men, living with and without HIV...
April 10, 2024: Nature Communications