keyword
https://read.qxmd.com/read/38545462/characterization-of-%C3%AE-synuclein-oligomers-formed-in-the-presence-of-lipid-vesicles
#1
JOURNAL ARTICLE
Anvesh K R Dasari, Urmi Sengupta, Elizabeth Viverette, Mario J Borgnia, Rakez Kayed, Kwang Hun Lim
Aggregation of α-synuclein into oligomers and fibrils is associated with numerous neurodegenerative diseases such as Parkinson's disease (PD). Although the identity of the pathogenic species formed during the aggregation process is still under active debate, mounting evidence suggests that small oligomeric species rather than fibrillar aggregates are real toxic species. Isolation and characterization of small oligomers is essential to developing therapeutic strategies to prevent oligomer formation. Preparation of misfolded oligomeric species for biophysical characterization is, however, a great challenge due to their heterogenous, transient nature...
July 2024: Biochemistry and Biophysics Reports
https://read.qxmd.com/read/38543856/a-comprehensive-review-of-neurodegenerative-manifestations-of-sars-cov-2
#2
REVIEW
Dominika Bedran, Georges Bedran, Sachin Kote
The World Health Organization reports that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted a staggering 770 million individuals to date. Despite the widespread nature of this viral infection, its precise effects remain largely elusive. This scientific inquiry aims to shed light on the intricate interplay between SARS-CoV-2 infection and the development of neurodegenerative disorders-an affliction that weighs heavily on millions worldwide and stands as the fourth most prevalent cause of mortality...
February 21, 2024: Vaccines
https://read.qxmd.com/read/38542297/alpha-synuclein-and-gm1-ganglioside-co-localize-in-neuronal-cytosol-leading-to-inverse-interaction-relevance-to-parkinson-s-disease
#3
JOURNAL ARTICLE
Ranjeet Kumar, Suman Chowdhury, Robert Ledeen
Research on GM1 ganglioside and its neuroprotective role in Parkinson's disease (PD), particularly in mitigating the aggregation of α-Synuclein (aSyn), is well established across various model organisms. This essential molecule, GM1, is intimately linked to preventing aSyn aggregation, and its deficiency is believed to play a key role in the initiation of PD. In our current study, we attempted to shed light on the cytosolic interactions between GM1 and aSyn based on previous reports demonstrating gangliosides and monomeric aSyn to be present in neuronal cytosol...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541625/the-value-of-subjective-olfactometry-as-a-predictive-biomarker-of-neurodegenerative-diseases-a-systematic-review
#4
REVIEW
Laia Ramos-Casademont, Daniel Martin-Jimenez, Brenda Villarreal-Garza, Serafín Sánchez-Gomez, María Amparo Callejon-Leblic
BACKGROUND: Olfactory disorders (ODs) are reported to be an early non-motor sign before the onset of deterioration in neurodegenerative diseases (NDs) such as Alzheimer's and Parkinson's. This systematic revision aims to review the current literature and the value of subjective olfactometry (SO) in the early diagnosis of cognitive decline and NDs. METHODS: A systematic literature review was conducted following the PRISMA framework. Four different authors reviewed six different databases...
February 23, 2024: Life
https://read.qxmd.com/read/38540694/neuroprotective-effects-of-the-nutraceutical-dehydrozingerone-and-its-c-2-symmetric-dimer-in-a-drosophila-model-of-parkinson-s-disease
#5
JOURNAL ARTICLE
Maria Dolores Setzu, Ignazia Mocci, Davide Fabbri, Paola Carta, Patrizia Muroni, Andrea Diana, Maria Antonietta Dettori, Maria Antonietta Casu
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons responsible for unintended or uncontrollable movements. Mutations in the leucine-rich repeat kinase 2 locus contribute to genetic forms of PD. The fruit fly Drosophila melanogaster carrying this mutation (LRRK2-Dm) is an in vivo model of PD that develops motor impairment and stands for an eligible non-mammalian paradigm to test novel therapeutic approaches. Dehydrozingerone (DHZ) is a natural phenolic compound isolated from ginger and presents anti-inflammatory, antioxidant and neuroprotective properties, making it a potential therapeutic target for PD...
February 24, 2024: Biomolecules
https://read.qxmd.com/read/38539252/role-of-gaba-pathway-in-motor-and-non-motor-symptoms-in-parkinson-s-disease-a-bidirectional-circuit
#6
REVIEW
Bandar Alharbi, Hayder M Al-Kuraishy, Ali I Al-Gareeb, Engy Elekhnawy, Hind Alharbi, Athanasios Alexiou, Marios Papadakis, Gaber El-Saber Batiha
Parkinson's disease (PD) is a progressive neurodegenerative disease as a result of the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). The fundamental features of PD are motor and non-motor symptoms. PD symptoms develop due to the disruption of dopaminergic neurotransmitters and other neurotransmitters such as γ-aminobutyric acid (GABA). The potential role of GABA in PD neuropathology concerning the motor and non-motor symptoms of PD was not precisely discussed. Therefore, this review intended to illustrate the possible role of GABA in PD neuropathology regarding motor and non-motor symptoms...
March 27, 2024: European Journal of Medical Research
https://read.qxmd.com/read/38538591/phosphorylation-and-o-glcnacylation-at-the-same-%C3%AE-synuclein-site-generate-distinct-fibril-structures
#7
JOURNAL ARTICLE
Jinjian Hu, Wencheng Xia, Shuyi Zeng, Yeh-Jun Lim, Youqi Tao, Yunpeng Sun, Lang Zhao, Haosen Wang, Weidong Le, Dan Li, Shengnan Zhang, Cong Liu, Yan-Mei Li
α-Synuclein forms amyloid fibrils that are critical in the progression of Parkinson's disease and serves as the pathological hallmark of this condition. Different posttranslational modifications have been identified at multiple sites of α-synuclein, influencing its conformation, aggregation and function. Here, we investigate how disease-related phosphorylation and O-GlcNAcylation at the same α-synuclein site (S87) affect fibril structure and neuropathology. Using semi-synthesis, we obtained homogenous α-synuclein monomer with site-specific phosphorylation (pS87) and O-GlcNAcylation (gS87) at S87, respectively...
March 27, 2024: Nature Communications
https://read.qxmd.com/read/38534318/nicotinic-acetylcholine-receptors-in-glial-cells-as-molecular-target-for-parkinson-s-disease
#8
REVIEW
Érica Novaes Soares, Ana Carla Dos Santos Costa, Gabriel de Jesus Ferrolho, Rodrigo Portes Ureshino, Bruk Getachew, Silvia Lima Costa, Victor Diogenes Amaral da Silva, Yousef Tizabi
Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) is the primary neurotransmitter involved in this disease, but cholinergic imbalance has also been implicated. Current intervention in PD is focused on replenishing central DA, which provides remarkable temporary symptomatic relief but does not address neuronal loss and the progression of the disease...
March 7, 2024: Cells
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#9
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38526966/neuroprotective-effect-of-green-tea-extract-epigallocatechin-3-gallate-in-a-preformed-fibril-induced-mouse-model-of-parkinson-s-disease
#10
JOURNAL ARTICLE
Jianing Shen, Junhua Xie, Liyuan Ye, Jian Mao, Shihao Sun, Weiwei Chen, Sijia Wei, Sisi Ruan, Linhai Wang, Hangcui Hu, Jingjing Wei, Yao Zheng, Zhouyan Xi, Ke Wang, Yan Xu
Parkinson's disease (PD) is the second most common neurodegenerative disease characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN). The main bioactive component of green tea polyphenols (-)-epigallocatechin-3-gallate (EGCG) exerts protective effects against diseases such as neurodegenerative diseases and cancer. Therefore, this study investigated the effect of EGCG on the amelioration of neural damage in a chronic PD mouse model induced by α-synuclein preformed fibrils (α-syn-PFFs)...
March 8, 2024: Neuroreport
https://read.qxmd.com/read/38526011/c9-functionalized-doxycycline-analogs-as-drug-candidates-to-prevent-pathological-%C3%AE-synuclein%C3%A2-aggregation-and-neuroinflammation-in-parkinson-s-disease-degeneration
#11
JOURNAL ARTICLE
Laurent Ferrié, Bruno Figadère, Clémence Rose, Rodrigo Hernán Tomas-Grau, Rosana Chehín, Brenda Zabala, Patrick Pierre Michel, Rita Raisman-Vozari, Jean-Michel Brunel
Doxycycline, a semi-synthetic tetracycline, is a widely used antibiotic for treating mild-to-moderate infections, including skin problems. However, its anti-inflammatory and antioxidant properties, combined with its ability to interfere with α-synuclein aggregation, make it an attractive candidate for repositioning in Parkinson's disease. Nevertheless, the antibiotic activity of doxycycline restricts its potential use for long-term treatment of Parkinsonian patients. In the search for non-antibiotic tetracyclines that could operate against Parkinson's disease pathomechanisms, eighteen novel doxycycline derivatives were designed...
March 25, 2024: ChemMedChem
https://read.qxmd.com/read/38518598/gut-microbiota-in-neurological-diseases-melatonin-plays-an-important-regulatory-role
#12
REVIEW
Somayeh Ahmadi, Mohammad Taghizadieh, Elham Mehdizadehfar, Alka Hasani, Javad Khalili Fard, Hadi Feizi, Hammed Hamishehkar, Masood Ansarin, Mina Yekani, Mohammad Yousef Memar
Melatonin is a highly conserved molecule produced in the human pineal gland as a hormone. It is known for its essential biological effects, such as antioxidant activity, circadian rhythm regulator, and immunomodulatory effects. The gut is one of the primary known sources of melatonin. The gut microbiota helps produce melatonin from tryptophan, and melatonin has been shown to have a beneficial effect on gut barrier function and microbial population. Dysbiosis of the intestinal microbiota is associated with bacterial imbalance and decreased beneficial microbial metabolites, including melatonin...
March 21, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38517806/parkinson-s-disease-in-sub-saharan-africa-pesticides-as-a-double-edged-sword
#13
REVIEW
Sarah J Urasa, Marieke C J Dekker, William P Howlett, Raphael J Mwezi, E Ray Dorsey, Bastiaan R Bloem
Long-term exposure to pesticides used in agriculture is increasingly being identified as a risk factor for developing Parkinson's disease. How chronic pesticide exposure might contribute to the growth of Parkinson's disease in the mainly agricultural communities of Sub-Saharan Africa has thus far received limited attention. There are specific concerns in this area of the world: aging of the population, in combination with chronic exposure to widely used pesticides, including those that have been restricted elsewhere in the world because of neurotoxicity and other health risks...
March 21, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38517803/gait-adaptability-and-the-effect-of-ocular-disorders-on-visually-guided-walking-in-parkinson-s-disease
#14
JOURNAL ARTICLE
Carlijn D J M Borm, Debbie De Graaf, Bastiaan R Bloem, Thomas Theelen, Carel Hoyng, Nienke de Vries, Vivian Weerdesteyn
Gait disorders are a disabling feature of Parkinson's disease (PD). To avoid falls, people with PD should be able to adequately adapt their gait. This requires correct response inhibition and integration of visual information. In this small pilot study, we investigated PD-related impairments in gait adaptability and the influence of ocular disorders thereon. Compared with controls, persons with PD were less able to adapt their gait in unexpected situations (U = 21.5, p = 0.013), with only a small influence of ocular disorders on precision stepping (U = 6, p = 0...
March 22, 2024: Journal of Parkinson's Disease
https://read.qxmd.com/read/38515319/antagonism-of-metabotropic-glutamate-receptor-type-5-prevents-levodopa-induced-dyskinesia-development-in-a-male-rat-model-of-parkinson-s-disease-electrophysiological-evidence
#15
JOURNAL ARTICLE
Hikaru Kamo, Hirokazu Iwamuro, Ryota Nakamura, Shuko Nojiri, Ayami Okuzumi, Takashi Ogawa, Asuka Nakajima, Nobutaka Hattori, Yasushi Shimo
Levodopa-induced dyskinesia (LID) is a common complication in patients with advanced Parkinson's disease (PD) undergoing treatment with levodopa. Glutamate receptor antagonists can suppress LID; however, the underlying mechanisms remain unclear. Here, we aimed to evaluate the effect of 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine (MTEP), a metabotropic glutamate receptor 5 (mGluR5) antagonist, on dyskinesia. We recorded the neuronal activity of the entopeduncular nucleus and examined responses to cortical electric stimulation in the control group (n = 6) and three groups of rats (male PD model)...
March 2024: Journal of Neuroscience Research
https://read.qxmd.com/read/38512027/rab3-phosphorylation-by-pathogenic-lrrk2-impairs-trafficking-of-synaptic-vesicle-precursors
#16
JOURNAL ARTICLE
Dan Dou, Jayne Aiken, Erika L F Holzbaur
Gain-of-function mutations in the LRRK2 gene cause Parkinson's disease (PD), characterized by debilitating motor and non-motor symptoms. Increased phosphorylation of a subset of RAB GTPases by LRRK2 is implicated in PD pathogenesis. We find that increased phosphorylation of RAB3A, a cardinal synaptic vesicle precursor (SVP) protein, disrupts anterograde axonal transport of SVPs in iPSC-derived human neurons (iNeurons) expressing hyperactive LRRK2-p.R1441H. Knockout of the opposing protein phosphatase 1H (PPM1H) in iNeurons phenocopies this effect...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38507813/targeting-neuroinflammation-by-pharmacologic-downregulation-of-inflammatory-pathways-is-neuroprotective-in-protein-misfolding-disorders
#17
JOURNAL ARTICLE
Sydney J Risen, Sean W Boland, Sadhana Sharma, Grace M Weisman, Payton M Shirley, Amanda S Latham, Arielle J D Hay, Vincenzo S Gilberto, Amelia D Hines, Stephen Brindley, Jared M Brown, Stephanie McGrath, Anushree Chatterjee, Prashant Nagpal, Julie A Moreno
Neuroinflammation plays a crucial role in the development of neurodegenerative protein misfolding disorders. This category of progressive diseases includes, but is not limited to, Alzheimer's disease, Parkinson's disease, and prion diseases. Shared pathogenesis involves the accumulation of misfolded proteins, chronic neuroinflammation, and synaptic dysfunction, ultimately leading to irreversible neuronal loss, measurable cognitive deficits, and death. Presently, there are few to no effective treatments to halt the advancement of neurodegenerative diseases...
March 20, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38504290/a-partial-drp1-knockout-improves-autophagy-flux-independent-of-mitochondrial-function
#18
JOURNAL ARTICLE
Rebecca Z Fan, Carolina Sportelli, Yanhao Lai, Said S Salehe, Jennifer R Pinnell, Harry J Brown, Jason R Richardson, Shouqing Luo, Kim Tieu
BACKGROUND: Dynamin-related protein 1 (Drp1) plays a critical role in mitochondrial dynamics. Partial inhibition of this protein is protective in experimental models of neurological disorders such as Parkinson's disease and Alzheimer's disease. The protective mechanism has been attributed primarily to improved mitochondrial function. However, the observations that Drp1 inhibition reduces protein aggregation in such neurological disorders suggest the involvement of autophagy. To investigate this potential novel protective mechanism of Drp1 inhibition, a model with impaired autophagy without mitochondrial involvement is needed...
March 19, 2024: Molecular Neurodegeneration
https://read.qxmd.com/read/38502289/an-evidence-based-update-on-anticholinergic-use-for-drug-induced-movement-disorders
#19
JOURNAL ARTICLE
Nora Vanegas-Arroyave, Stanley N Caroff, Leslie Citrome, Jovita Crasta, Roger S McIntyre, Jonathan M Meyer, Amita Patel, J Michael Smith, Khody Farahmand, Rachel Manahan, Leslie Lundt, Samantha A Cicero
Drug-induced movement disorders (DIMDs) are associated with use of dopamine receptor blocking agents (DRBAs), including antipsychotics. The most common forms are drug-induced parkinsonism (DIP), dystonia, akathisia, and tardive dyskinesia (TD). Although rare, neuroleptic malignant syndrome (NMS) is a potentially life-threatening consequence of DRBA exposure. Recommendations for anticholinergic use in patients with DIMDs were developed on the basis of a roundtable discussion with healthcare professionals with extensive expertise in DIMD management, along with a comprehensive literature review...
March 19, 2024: CNS Drugs
https://read.qxmd.com/read/38501767/resveratrol-prevents-cognitive-deficits-induced-by-sleep-deprivation-via-modulating-sirtuin-1-associated-pathways-in-the-hippocampus
#20
JOURNAL ARTICLE
Yue-Ming Zhang, Ru-Meng Wei, Jing-Ya Zhang, Shuang Liu, Kai-Xuan Zhang, Xiao-Yi Kong, Yi-Jun Ge, Xue-Yan Li, Gui-Hai Chen
Accumulating evidence confirms that sleep insufficiency is a high risk factor for cognitive impairment, which involves inflammation and synaptic dysfunction. Resveratrol, an agonist of the Sirt1, has demonstrated anti-inflammation and neuroprotective effects in models of Alzheimer's disease, Parkinson's disease, and schizophrenia. However, the beneficial effects of resveratrol on sleep deprivation-induced cognitive deficits and its underlying molecular mechanisms are unclear. In the present study, thirty-two male C57BL/6 J mice were randomly divided into a Control+DMSO group, Control+Resveratrol group, SD+DMSO group, and SD+Resveratrol group...
April 2024: Journal of Biochemical and Molecular Toxicology
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