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https://www.readbyqxmd.com/read/28814509/chemoproteomics-reveals-chemical-diversity-and-dynamics-of-4-oxo-2-nonenal-modifications-in-cells
#1
Rui Sun, Ling Fu, Ke-Ke Liu, Cai-Ping Tian, Yong Yang, Keri A Tallman, Ned A Porter, Daniel C Liebler, Jing Yang
4-Oxo-2-nonenal (ONE) derived from lipid peroxidation modifies nucleophiles and transduces redox signaling by its reactions with proteins. However, the molecular interactions between ONE and complex proteomes and their dynamics in situ remain largely unknown. Here we describe a quantitative chemoproteomic analysis of protein adduction by ONE in cells, in which the cellular target profile of ONE is mimicked by its alkynyl surrogate. The analyses reveal four types of ONE-derived modifications in cells, including ketoamide and Schiff-base adducts to lysine, Michael adducts to cysteine, and a novel pyrrole adducts to cysteine...
August 16, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28812483/first-world-war-the-first-big-test-of-professional-nursing
#2
Jennifer Trueland
When Helen Fairchild, a young nurse in Pennsylvania, volunteered to take her skills to Europe in the first world war, she was glad to go but felt sorry for her mother. 'If she would only not worry so much', she wrote to her brother Ned.
August 16, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28809954/the-burden-of-septic-arthritis-on-the-u-s-inpatient-care-a-national-study
#3
Jasvinder A Singh, Shaohua Yu
OBJECTIVE: To assess the health care burden of septic arthritis in the U.S. and examine the associated factors. METHODS: We used the U.S. Nationwide Emergency Department Sample (NEDS) data of patients hospitalized with septic arthritis as the primary diagnosis from 2009-12 to assess time-trends. Multivariable-adjusted models assessed demographics, comorbidity and hospital characteristics as potential predictors of duration of hospitalization, total hospital (inpatient and ED) charges and discharge to home...
2017: PloS One
https://www.readbyqxmd.com/read/28804908/influence-of-abiraterone-acetate-on-neuroendocrine-differentiation-in-chemotherapy-naive-metastatic-castration-resistant-prostate-cancer
#4
Baijun Dong, Liancheng Fan, Yanqing Wang, Chenfei Chi, Xiaowei Ma, Rui Wang, Wen Cai, Xiaoguang Shao, Jiahua Pan, Yinjie Zhu, Xun Shangguan, Zhixiang Xin, Jianian Hu, Shaowei Xie, Xiaonan Kang, Lixin Zhou, Wei Xue
BACKGROUND: To determine the influence of abiraterone Acetate (AA) on neuroendocrine differentiation (NED) in patients with chemotherapy-naive metastatic castration-resistant prostate cancer (mCRPC). METHODS: We conducted an analysis in 115 chemotherapy-naïve mCRPC patients who would be treated with chemotherapy. The serum levels of chromogranin A (CgA), neurone-specific enolase (NSE) were measured in 67 mCRPC patients without AA treatment and 48 patients after the failure of AA treatment, in which these markers were also measured in 34 patients before and after 6 months of AA treatment...
August 14, 2017: Prostate
https://www.readbyqxmd.com/read/28796722/accuracy-and-repeatability-of-automated-injector-versus-manual-administration-of-an-mri-contrast-agent-results-of-a-laboratory-study
#5
Jan Endrikat, Ron Barbati, Marcella Scarpa, Gregor Jost, Arthur E Ned Uber
OBJECTIVE: The aim of this study was to compare flow rates over time and the deviations from the target flow rate of a magnetic resonance imaging contrast agent achieved by an automated injector versus manual injection. MATERIALS AND METHODS: In this laboratory study, the magnetic resonance contrast agent gadobutrol was repeatedly injected by an injector and by 10 experienced technologists. Six scenarios with 2 different target flow rates (1 and 5 mL/s), 2 different contrast volumes (10 and 20 mL), and 2 different intravenous (IV) catheters (22 gauge and 20 gauge) were tested...
August 7, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28765965/downregulation-of-smp30-in-senescent-human-lens-epithelial-cells
#6
Shuning Li, Xi Chen, Weixia Lai, Meixia Hu, Xin Zhong, Shaojian Tan, Hao Liang
Senescence marker protein 30 (SMP30) has been reported to serve antiapoptotic and antioxidant roles, as well as roles in Ca2+ regulation, and may be involved in the occurrence and development of cataract. The present study aimed to investigate the expression of SMP30 in senescent human lens epithelial cells (HLECs) and explored the relationship between SMP30 and aging. SRA01/04 cells, a HLEC line, were treated with H2O2 to mimic aging, and cell morphological changes were observed by microscopy and cell activity was exami-ned by MTT assay, senescence‑associated‑β‑galactosidase (SA‑β‑Gal) staining and cell cycle analysis...
July 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28755792/quantifying-image-quality-improvement-using-elevated-acoustic-output-in-b-mode-harmonic-imaging
#7
Yufeng Deng, Mark L Palmeri, Ned C Rouze, Gregg E Trahey, Clare M Haystead, Kathryn R Nightingale
Tissue harmonic imaging has been widely used in abdominal imaging because of its significant reduction in acoustic noise compared with fundamental imaging. However, tissue harmonic imaging can be limited by both signal-to-noise ratio and penetration depth during clinical imaging, resulting in decreased diagnostic utility. A logical approach would be to increase the source pressure, but the in situ pressures used in diagnostic ultrasound are subject to a de facto upper limit based on the U.S. Food and Drug Administration guideline for the mechanical index (<1...
July 26, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28753425/identification-of-phosphorylation-codes-for-arrestin-recruitment-by-g-protein-coupled-receptors
#8
X Edward Zhou, Yuanzheng He, Parker W de Waal, Xiang Gao, Yanyong Kang, Ned Van Eps, Yanting Yin, Kuntal Pal, Devrishi Goswami, Thomas A White, Anton Barty, Naomi R Latorraca, Henry N Chapman, Wayne L Hubbell, Ron O Dror, Raymond C Stevens, Vadim Cherezov, Vsevolod V Gurevich, Patrick R Griffin, Oliver P Ernst, Karsten Melcher, H Eric Xu
G protein-coupled receptors (GPCRs) mediate diverse signaling in part through interaction with arrestins, whose binding promotes receptor internalization and signaling through G protein-independent pathways. High-affinity arrestin binding requires receptor phosphorylation, often at the receptor's C-terminal tail. Here, we report an X-ray free electron laser (XFEL) crystal structure of the rhodopsin-arrestin complex, in which the phosphorylated C terminus of rhodopsin forms an extended intermolecular β sheet with the N-terminal β strands of arrestin...
July 27, 2017: Cell
https://www.readbyqxmd.com/read/28752495/changing-clinical-phenotypes-of-hiv-associated-neurocognitive-disorders
#9
Ned Sacktor
HIV-associated neurocognitive disorder (HAND) remains a common cause of cognitive impairment and persists in 15-55% of HIV+ individuals in the combination antiretroviral therapy (CART) era. CART is now the primary treatment for HAND, but it is effective in only a subset of patients. In the pre-CART era, HIV-associated dementia was the most common form of HAND. However, in CART-treated patients, the prevalence of HIV-associated dementia has declined substantially, and milder stages of HAND, i.e., ANI and MND predominate...
July 27, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28751916/sertoli-leydig-cell-tumor-with-concurrent-rhabdomyosarcoma-three-case-reports-and-a-review-of-the-literature
#10
Trisha Plastini, Arthur Staddon
Sertoli-Leydig Cell Tumors (SLCTs) make up <1% of all ovarian tumors and are benign or malignant, androgen-secreting tumors. Rhabdomyosarcoma (RMS) is a heterogeneous group of malignant tumors that resemble developing skeletal muscle. There have been case reports of patients with concurrent SLCT and RMS with limited treatment options. We aim to demonstrate treatment strategies used in our patients, which seemed to have prolonged survival when compared to prior case reports of patients not cured by surgical resection...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28734980/histone-demethylase-phf8-regulates-hypoxia-signaling-through-hif1%C3%AE-and-h3k4me3
#11
Peterson Kariuki Maina, Peng Shao, Xiongfei Jia, Qi Liu, Shaikamjad Umesalma, Maximo Marin, Donald Long, Samantha Concepción-Román, Hank Heng Qi
Hypoxia through transcription factor HIF1α plays a critical role in cancer development. In prostate cancer, HIF1α interplays with androgen receptor (AR) to contribute to the progression of this disease to its lethal form-castration-resistant prostate cancer (CRPC). Hypoxia upregulates several epigenetic factors including histone demethylase KDM3A which is a critical co-factor of HIF1α. However, how histone demethylases regulate hypoxia signaling is not fully understood. Here, we report that histone demethylase PHF8 plays an essential role in hypoxia signaling...
July 19, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28733030/accounting-for-the-spatial-observation-window-in-the-2-d-fourier-transform-analysis-of-shear-wave-attenuation
#12
Ned C Rouze, Yufeng Deng, Mark L Palmeri, Kathryn R Nightingale
Recent measurements of shear wave propagation in viscoelastic materials have been analyzed by constructing the 2-D Fourier transform (2DFT) of the shear wave signal and measuring the phase velocity c(ω) and attenuation α(ω) from the peak location and full width at half-maximum (FWHM) of the 2DFT signal at discrete frequencies. However, when the shear wave is observed over a finite spatial range, the 2DFT signal is a convolution of the true signal and the observation window, and measurements using the FWHM can yield biased results...
July 18, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28725425/letter-to-the-editor-health-professionals-attitudes-toward-individuals-with-eating-disorders-who-do-we-think-they-are
#13
Deborah Lynn Reas, Kjersti Solhaug Gulliksen, Johanna Levallius, Rasmus Isomaa
Health professionals are not immune to stigmatizing attitudes and stereotypes found in society-at-large. Along with patients and their loved ones, treatment providers are important stakeholders - and gatekeepers - in the successful delivery of mental healthcare. Prevailing attitudes among professionals can facilitate timely recognition, enable access to care and uptake of evidence-based practices, or undermine help-seeking and therapeutic engagement. At an interactive activity at the 2016 Nordic Eating Disorders Society (NEDS) meeting, we asked health professionals to describe individuals with eating disorders...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28719577/physical-limits-to-biomechanical-sensing-in-disordered-fibre-networks
#14
Farzan Beroz, Louise M Jawerth, Stefan Münster, David A Weitz, Chase P Broedersz, Ned S Wingreen
Cells actively probe and respond to the stiffness of their surroundings. Since mechanosensory cells in connective tissue are surrounded by a disordered network of biopolymers, their in vivo mechanical environment can be extremely heterogeneous. Here we investigate how this heterogeneity impacts mechanosensing by modelling the cell as an idealized local stiffness sensor inside a disordered fibre network. For all types of networks we study, including experimentally-imaged collagen and fibrin architectures, we find that measurements applied at different points yield a strikingly broad range of local stiffnesses, spanning roughly two decades...
July 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28719043/implementation-rates-of-uro-oncology-multi-disciplinary-meeting-decisions
#15
Ned Kinnear, Riley Smith, Derek B Hennessey, Damien Bolton, Shomik Sengupta
OBJECTIVES: To assess implementation rates of the consensus plans made at the uro-oncology multidisciplinary meeting (MDM) of an Australian tertiary centre, and analyse obstacles to implementation. METHODS: A retrospective review was performed of all patients discussed at the uro-oncology MDM at our institution between 1 January to 30 June 2015. Rates of referral for MDM discussion following a new histological diagnosis of malignancy, categorised by tumour type, were assessed...
July 18, 2017: BJU International
https://www.readbyqxmd.com/read/28718951/response-to-therapy-of-papillary-thyroid-cancer-of-known-braf-status
#16
Aldona Kowalska, Agnieszka Walczyk, Artur Kowalik, Iwona Pałyga, Danuta Gąsior-Perczak, Tomasz Trybek, Janusz Kopczyński, Maciej Kajor, Estera Mikina, Monika Szymonek, Klaudia Gadawska-Juszczyk, Dorota Szyska-Skrobot, Katarzyna Lizis-Kolus, Stefan Hurej, Magdalena Chrapek, Małgorzata Chłopek, Stanisław Góźdź
CONTEXT: A dynamic risk stratification with modified initial estimated risk based on response to therapy and disease course is one of the crucial changes adopted recently by the American Thyroid Association (ATA). This approach focuses on an individualized risk-adapted approach to the management of differentiated thyroid cancer. The BRAF V600E mutation is the most common genetic alteration in papillary thyroid cancer (PTC). However, the prognostic value of this mutation remains unclear...
July 18, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28716545/effect-of-ageing-on-neurocognitive-function-by-stage-of-hiv-infection-evidence-from-the-multicenter-aids-cohort-study
#17
Karl Goodkin, Eric N Miller, Christopher Cox, Sandra Reynolds, James T Becker, Eileen Martin, Ola A Selnes, David G Ostrow, Ned C Sacktor
BACKGROUND: The demographics of the HIV epidemic in the USA have shifted towards older age. We aimed to establish the relationship between the processes of ageing and HIV infection in neurocognitive impairment. METHODS: With longitudinal data from the Multicenter AIDS Cohort Study, a long-term prospective cohort study of the natural and treated history of HIV infection among men who have sex with men in the USA, we examined the effect of ageing, HIV infection (by disease stage), and their interaction on five neurocognitive domains: information processing speed, executive function, episodic memory, working memory, and motor function...
July 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28712862/determination-of-7-be-and-22-na-activity-in-air-and-rainwater-samples-by-gamma-ray-spectrometry
#18
M I Savva, D J Karangelos, M J Anagnostakis
Natural radionuclides, such as short lived radon daughters and (7)Be, have been analyzed in aerosols at the Nuclear Engineering Department of the National Technical University of Athens (NED-NTUA) since many years, with high accuracy and precision. During this research, an effort to detect (22)Na and determine (7)Be/(22)Na ratio in aerosols is presented. In order to study the role of precipitation in surface air (7)Be and (22)Na activity concentration, a procedure for collecting and analyzing rainwater was developed...
July 10, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28709358/analytic-solutions-throughout-a-period-doubling-route-to-chaos
#19
Marko S Milosavljevic, Jonathan N Blakely, Aubrey N Beal, Ned J Corron
We show examples of dynamical systems that can be solved analytically at any point along a period doubling route to chaos. Each system consists of a linear part oscillating about a set point and a nonlinear rule for regularly updating that set point. Previously it has been shown that such systems can be solved analytically even when the oscillations are chaotic. However, these solvable systems show few bifurcations, transitioning directly from a steady state to chaos. Here we show that a simple change to the rule for updating the set point allows for a greater variety of nonlinear dynamical phenomena, such as period doubling, while maintaining solvability...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708736/mifepristone-plasma-level-and-glucocorticoid-receptor-antagonism-associated-with-response-in-patients-with-psychotic-depression
#20
Thaddeus Block, Georgios Petrides, Harvey Kushner, Ned Kalin, Joseph Belanoff, Alan Schatzberg
BACKGROUND: Psychotic depression has no Food and Drug Administration-approved treatment. Patients demonstrate significant dysregulation of the hypothalamic-pituitary-adrenal axis providing a biologically targeted treatment opportunity. The purpose of this study was to explore the clinical and biological effects of short-duration (7-day) glucocorticoid receptor antagonism with mifepristone and the role of mifepristone plasma levels in patients with psychotic depression. METHODS: This double-blind, randomized study took place at 34 US clinical research centers and included patients with a diagnosis of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, major depressive disorder, severe, with psychotic features...
July 13, 2017: Journal of Clinical Psychopharmacology
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