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https://www.readbyqxmd.com/read/29138344/targeting-the-mycn-parp-dna-damage-response-pathway-inneuroendocrine-prostate-cancer
#1
Wei Zhang, Bo Liu, Wenhui Wu, Likun Li, Bradley M Broom, Spyridon M Basourakos, Dimitrios Korentzelos, Yang Luan, Jianxiang Wang, Guang Yang, Sanghee Park, Abul K Azad, Xuhong Cao, Jeri Kim, Paul Corn, Christopher Logothetis, Ana M Aparicio, Arul M Chinnayan, Nora M Navone, Patricia Troncoso, Timothy C Thompson
PURPOSE: We investigated MYCN-regulated molecular pathways in castration-resistant prostate cancer (CRPC) classified by morphological criteria as adenocarcinoma or neuroendocrine to extend the molecular phenotype, establish driver pathways, and identify novel approaches to combination therapy for NEPC. RESULTS: Using comparative bioinformatics analyses of CRPC-Adeno and CRPC-Neuro RNA sequence data from public datasets and a panel of 28 PDX models we identified a MYCN-PARP-DNA damage response (DDR) pathway that is enriched in CRPC with neuroendocrine differentiation (NED) and CRPC-Neuro...
November 14, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29131446/food-provision-among-food-relief-agencies-in-rural-australia-and-perceived-barriers-and-enablers-to-provide-healthy-food
#2
Natalia Bortolin, Jaqueline Priestly, Janice Sangster
OBJECTIVE: Food insecurity affects 4-14% of Australians, and up to 82% of vulnerable groups. Food relief agencies commonly provide food parcels or food vouchers. Little research has been undertaken on food relief agencies within rural Australia. This study determined the type of food assistance provided by rural FRAs, and barriers and enablers to provide healthy food. DESIGN: Cross-sectional study, using telephone questionnaires with qualitative and quantitative aspects...
November 13, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29127031/sulfur-mustard-induced-mast-cell-degranulation-in-mouse-skin-is-inhibited-by-a-novel-anti-inflammatory-and-anticholinergic-bifunctional-prodrug
#3
Laurie B Joseph, Gabriella M Composto, Roberto M Perez, Hong-Duck Kim, Robert P Casillas, Ned D Heindel, Sherri C Young, Carl J Lacey, Jaya Saxena, Christophe D Guillon, Claire R Croutch, Jeffrey D Laskin, Diane E Heck
Sulfur mustard (SM, bis(2-chloroethyl sulfide) is a potent vesicating agent known to cause skin inflammation, necrosis and blistering. Evidence suggests that inflammatory cells and mediators that they generate are important in the pathogenic responses to SM. In the present studies we investigated the role of mast cells in SM-induced skin injury using a murine vapor cup exposure model. Mast cells, identified by toluidine blue staining, were localized in the dermis, adjacent to dermal appendages and at the dermal/epidermal junction...
November 7, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/29121783/trends-in-upper-extremity-injuries-presenting-to-us-emergency-departments
#4
Eric Wenzinger, Angel Rivera-Barrios, Gil Gonzalez, Fernando Herrera
BACKGROUND: The purpose of this study was to identify the incidence of upper extremity injuries presenting to emergency departments (EDs) nationally. METHODS: The Nationwide Emergency Department Sample (NEDS) database was queried using International Classification of Diseases, Ninth Revision (ICD-9) codes specific for hand/wrist injuries to identify national estimates of ED visits. The incidence, mean age, gender, payer mix, hospital type, location (metropolitan vs nonmetropolitan), and geographic region were recorded...
November 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29111807/book-reviews-fundamentals-of-anaesthesia-4th-edn-edited-by-ted-lin-tim-smith-colin-pinnock-cambridge-university-press-2017-price-%C3%A2-84-99-pp-983-isbn-9781107612389-aging-and-development-social-and-emotional-perspectives-2nd-edn-peter-f-coleman-ann-o-hanlon-routledge
#5
https://www.readbyqxmd.com/read/29111684/correction-to-a-chemoproteomic-platform-to-assess-bioactivation-potential-of-drugs
#6
Rui Sun, Fuguo Shi, Keke Liu, Ling Fu, Caiping Tian, Yong Yang, Keri A Tallman, Ned A Porter, Jing Yang
No abstract text is available yet for this article.
November 7, 2017: Chemical Research in Toxicology
https://www.readbyqxmd.com/read/29109909/estrogen-therapy-offsets-thermal-impairment-of-vitellogenesis-but-not-zonagenesis-in-maiden-spawning-female-atlantic-salmon-salmo-salar
#7
Kelli Anderson, Ned Pankhurst, Harry King, Abigail Elizur
In female Atlantic salmon (Salmo salar), exposure to warm summer temperatures causes a reduction in plasma 17β-estradiol (E2), which impairs downstream vitellogenesis and zonagenesis, and reduces egg fertility and embryo survival. The aim of the present study was to determine whether E2-treatment could offset thermal impairment of endocrine function and maintain egg quality in maiden (first-time-spawning) S. salar reared at 22 °C. Treatment with E2 at 22 °C stimulated vitellogenin (vtg) gene expression and subsequent protein synthesis which promoted oocyte growth and increased egg size relative to untreated fish at 14 and 22 °C...
2017: PeerJ
https://www.readbyqxmd.com/read/29103755/a-failure-type-specific-risk-prediction-tool-for-selection-of-head-and-neck-cancer-patients-for-experimental-treatments
#8
Katrin Håkansson, Jacob H Rasmussen, Gregers B Rasmussen, Jeppe Friborg, Thomas A Gerds, Barbara Malene Fischer, Flemming L Andersen, Søren M Bentzen, Lena Specht, Ivan R Vogelius
OBJECTIVES: The objective of this work was to develop a tool for decision support, providing simultaneous predictions of the risk of loco-regional failure (LRF) and distant metastasis (DM) after definitive treatment for head-and-neck squamous cell carcinoma (HNSCC). MATERIALS AND METHODS: Retrospective data for 560HNSCC patients were used to generate a multi-endpoint model, combining three cause-specific Cox models (LRF, DM and death with no evidence of disease (death NED))...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29078131/neuromuscular-electrophysiological-disorders-and-muscle-atrophy-in-mechanically-ventilated-traumatic-brain-injury-patients-new-insights-from-a-prospective-observational-study
#9
Paulo Eugênio Silva, Vinicius Maldaner, Luciana Vieira, Karina Livino de Carvalho, Hedian Gomes, Priscilla Melo, Nicolas Babault, Gerson Cipriano, Joao Luiz Quagliotti Durigan
PURPOSE: It is unclear whether the muscular changes in mechanically-ventilated traumatic brain injury patients (TBI) are only associated with disuse or additionally to neuromuscular electrophysiological disorders (NED). The correlation between muscle atrophy and NED may affect functional outcomes and rehabilitation programs significantly. MATERIAL AND METHODS: An observational study was performed to investigate the presence of NED and muscle atrophy in TBI patients undergoing mechanical ventilation...
October 19, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29068682/activity-based-probes-for-isoenzyme-and-site-specific-functional-characterization-of-glutathione-s-transferases
#10
Ethan G Stoddard, Bryan J Killinger, Reji N Nair, Natalie C Sadler, Regan F Volk, Samuel O Purvine, Anil K Shukla, Jordan N Smith, Aaron T Wright
Glutathione S-transferases (GSTs) comprise a diverse family of phase II drug metabolizing enzymes whose shared function is the conjugation of reduced glutathione (GSH) to endo- and xenobiotics. Although the conglomerate activity of these enzymes can be measured, the isoform-specific contribution to the metabolism of xenobiotics in complex biological samples has not been possible. We have developed two activity-based probes (ABPs) that characterize active GSTs in mammalian tissues. The GST active site is composed of a GSH binding "G site" and a substrate binding "H site"...
November 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29064563/comparison-of-purification-strategies-for-antibodies-used-in-a-broad-spectrum-host-cell-protein-immunoassay
#11
Phoebe A Baldus, Matthew Brown, Richard S Wright, Jessica A Campbell, Scott Lute, Brittany Chavez, Kurt Brorson, Ned Mozier
Host cell proteins (HCPs) are a heterogeneous mixture of impurities that should be minimized in bulk preparations of biotechnologically produced medicines. Immunoassays are commonly used to detect and measure HCPs in therapeutic products, and a successful assay is directly dependent on the quality of the polyclonal antibodies (pAbs) used. These pAbs are enriched from antisera of animals immunized with a broad mixture of HCPs, but there is limited information regarding the best strategy for purification of these critical reagents...
October 24, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29063516/paroxetine-and-fluconazole-therapy-for-hiv-associated-neurocognitive-impairment-results-from-a-double-blind-placebo-controlled-trial
#12
Ned Sacktor, Richard L Skolasky, Richard Moxley, Sheng Wang, Michelle M Mielke, Cynthia Munro, Joseph Steiner, Avindra Nath, Norman Haughey, Justin McArthur
Paroxetine and fluconazole have neuroprotective effects in an in vitro model of HIV protein-mediated neuronal injury. This study evaluated the safety, tolerability, and efficacy of both paroxetine and fluconazole for the treatment of HIV-associated neurocognitive disorder (HAND). A 24-week randomized double-blind, placebo-controlled 2 × 2 factorial design study was used. HIV+ individuals with cognitive impairment were enrolled in the 24-week trial. Participants were randomly assigned to one of four groups: (1) paroxetine 20 mg/day, (2) fluconazole 100 mg every 12 h, (3) paroxetine and fluconazole, or (4) placebo...
October 23, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/29062760/the-experiences-and-challenges-faced-by-rehabilitation-community-service-therapists-within-the-south-african-primary-healthcare-health-system
#13
Lieketseng Ned, Lizahn Cloete, Gubela Mji
BACKGROUND: Twenty-two years after the promulgation of a plethora of progressive health policies since 1994, the South African public health system reflects a number of stumbling blocks regarding implementation. Rehabilitation professionals are not sufficiently equipped nor allowed the opportunity to comprehensively implement Primary Healthcare (PHC) from a bottom-up approach, thus engaging communities. Training on addressing social health determinants and their impact on ill-health and health outcomes is inadequate...
2017: Afr J Disabil
https://www.readbyqxmd.com/read/29062601/effects-of-gnrha-treatment-during-vitellogenesis-on-the-reproductive-physiology-of-thermally-challenged-female-atlantic-salmon-salmo-salar
#14
Kelli Anderson, Ned Pankhurst, Harry King, Abigail Elizur
Tasmanian Atlantic salmon (S. salar) broodstock can experience temperatures above 20 °C, which impairs reproductive development and inhibits ovulation. The present study investigated the prolonged use of gonadotropin releasing hormone analogue (GnRHa) during vitellogenesis as a means of maintaining endocrine function and promoting egg quality at elevated temperature in maiden and repeat spawning S. salar. GnRHa-treatment during vitellogenesis did not compensate for the negative effects of thermal challenge on the timing of ovulation, egg size, egg fertility or embryo survival in any fish maintained at 22 °C relative to 14 °C...
2017: PeerJ
https://www.readbyqxmd.com/read/29060351/surgical-gesture-classification-using-dynamic-time-warping-and-affine-velocity
#15
Jenny Cifuentes, Minh Tu Pham, Richard Moreau, Flavio Prieto, Pierre Boulanger
Minimally Invasive Surgery (MIS) has become widespread as an important surgical technique due to its advantages related to pain relief and short recovery time periods. However, this approach implies the acquisition of special surgical skills, which represents a challenge in the objective assessment of surgical gestures. In this way, several studies shown that kinematics and kinetic analysis of hand movement is a valuable assessment tool of basic surgical skills in MIS. In addition, recent researches proved that human motion performed during surgery can be described as a sequence of constant affine velocity movements...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052240/testing-predictions-of-the-emotion-regulation-model-of-binge-eating-disorder
#16
Therese E Kenny, Christopher Singleton, Jacqueline C Carter
OBJECTIVE: The emotion regulation (ER) model of binge eating posits that individuals with binge-eating disorder (BED) experience more intense emotions and greater difficulties in ER than individuals without BED, leading them to binge eat as a means of regulating emotions. According to this model, individuals with BED should report greater difficulties in ER than their non-BED counterparts, the severity of these difficulties should be positively associated with BED symptoms, and this association should be stronger when individuals experience persistent negative emotions (i...
October 20, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/29049538/3d-printed-mitral-valve-models-affordable-simulation-for-robotic-mitral-valve-repair
#17
Ned Premyodhin, Divneet Mandair, Alice S Ferng, Timothy S Leach, Ryan P Palsma, Mohammad Z Albanna, Zain I Khalpey
OBJECTIVES: 3D printed mitral valve (MV) models that capture the suture response of real tissue may be utilized as surgical training tools. Leveraging clinical imaging modalities, 3D computerized modelling and 3D printing technology to produce affordable models complements currently available virtual simulators and paves the way for patient- and pathology-specific preoperative rehearsal. METHODS: We used polyvinyl alcohol, a dissolvable thermoplastic, to 3D print moulds that were casted with liquid platinum-cure silicone yielding flexible, low-cost MV models capable of simulating valvular tissue...
July 31, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29047842/breaking-camouflage-and-detecting-targets-require-optic-flow-and-image-structure-information
#18
Jing Samantha Pan, Ned Bingham, Chang Chen, Geoffrey P Bingham
Use of motion to break camouflage extends back to the Cambrian [In the Blink of an Eye: How Vision Sparked the Big Bang of Evolution (New York Basic Books, 2003)]. We investigated the ability to break camouflage and continue to see camouflaged targets after motion stops. This is crucial for the survival of hunting predators. With camouflage, visual targets and distracters cannot be distinguished using only static image structure (i.e., appearance). Motion generates another source of optical information, optic flow, which breaks camouflage and specifies target locations...
August 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/29030526/guidelines-for-risk-based-changeover-of-biopharma-multi-product-facilities
#19
Rob Lynch, David B, Kathleen Bellorado, Peter Canisius, Douglas Heathcote, Alan Johnson, Ned Wymann, Derek Willison-Parry
In multi-product Biopharma facilities, the protection from product contamination due to the manufacture of multiple products simultaneously, is paramount to assure product quality. To that end, the use of traditional changeover methods (elastomer change-out, full sampling, etc.) have been widely used within the industry and have been accepted by regulatory agencies. However, with the endorsement of Quality Risk Management , the use of risk based approaches may be applied to assess and continuously improve established changeover processes...
October 12, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29028828/ised-constructing-a-high-resolution-elevation-road-dataset-from-massive-low-quality-in-situ-observations-derived-from-geosocial-fitness-tracking-data
#20
Grant McKenzie, Krzysztof Janowicz
Gaining access to inexpensive, high-resolution, up-to-date, three-dimensional road network data is a top priority beyond research, as such data would fuel applications in industry, governments, and the broader public alike. Road network data are openly available via user-generated content such as OpenStreetMap (OSM) but lack the resolution required for many tasks, e.g., emergency management. More importantly, however, few publicly available data offer information on elevation and slope. For most parts of the world, up-to-date digital elevation products with a resolution of less than 10 meters are a distant dream and, if available, those datasets have to be matched to the road network through an error-prone process...
2017: PloS One
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