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https://www.readbyqxmd.com/read/28644969/premotor-symptoms-and-the-risk-of-parkinson-s-disease-a-case-control-study-in-mexican-population
#1
Mayela Rodríguez-Violante, Adib Jorge de Saráchaga, Amin Cervantes-Arriaga, Ned Merari Davila-Avila, Edith Carreón-Bautista, Ingrid Estrada-Bellmann, Guillermo Parra-López, Diego Cruz-Fino, Francisco Pascasio-Astudillo
OBJECTIVES: To assess the prevalence of pre-motor symptoms and estimate the risk for developing Parkinson's disease in Mexican population. PATIENTS AND METHODS: A case-control study was carried out with consecutive subjects with Parkinson's disease from two different referral centers in Mexico. Gender- and age-matched controls were randomly selected from the participating hospitals. All subjects were assessed using a structured questionnaire for the assessment of pre-motor symptoms (hyposmia, depression, anxiety, constipation, and sleep disorders)...
June 15, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28642249/unc-cancer-center-director-to-lead-nci
#2
(no author information available yet)
President Donald Trump has selected Norman "Ned" Sharpless, MD, director of the University of North Carolina Lineberger Comprehensive Cancer Center, to lead the NCI. The news was met with widespread approval among cancer researchers, who view Sharpless as a strong communicator who can ably represent the needs of the cancer community in the face of proposed funding cuts.
June 22, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28630247/saksenaea-vasiformis-infection-in-an-immunocompetent-patient-in-rural-australia
#3
Wiktor Teodor Pilch, Ned Kinnear, Derek Barry Hennessey
An 81-year-old man from rural Australia presented with right pretibial cellulitis 7 days after minor trauma against furniture. He failed to improve despite antibiotics and surgical debridement. Subsequent cultures grew the rare fungus Saksenaea vasiformis, which was treated with further surgical debridement, amphotericin B and posaconazole. This was successful and the patient made a full recovery. We present the case and discuss lessons learnt.
June 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28627184/implementaci%C3%A3-n-de-una-v%C3%A3-a-cl%C3%A3-nica-de-prescripci%C3%A3-n-de-nutrici%C3%A3-n-enteral-domiciliaria-de-murcia-perfiles-y-caracter%C3%A3-sticas-muestrales
#4
Mercedes Ferrer Gómez, Juan Francisco Sánchez Romera, María Victoria García Zafra, José Ramón Cuenca Sánchez, Ana Belén Hernández Cascales, Ana Aranda García, Víctor José Rausell Rausell, Antonio Miguel Hernández Martínez
Introducción: el escenario de la nutrición enteral domiciliaria (NED) en Murcia, antes de 2010, estaba caracterizado por la gran variabilidad en la consideración del paciente subsidiario de dicha prestación, así como por el elevado consumo respecto a otras comunidades autónomas.Objetivos: desarrollar y describir la implementación de una vía clínica de asistencia al paciente subsidiario de NED y analizar el perfil de los pacientes y las características del soporte nutricional.Método: puesta en marcha de la vía clínica en el Área I de salud del Servicio Murciano de Salud (SMS)...
June 5, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28624057/surveillance-strategies-in-the-follow-up-of-melanoma-patients-too-much-or-not-enough
#5
James Kurtz, Georgia M Beasley, Doreen Agnese, Kari Kendra, Thomas E Olencki, Alicia Terando, J Harrison Howard
BACKGROUND: After appropriate initial therapy for patients with stage II-III melanoma, there is no consensus regarding surveillance. Thus, follow-up is highly variable among institutions and individual providers. The National Comprehensive Cancer Network recommends routine clinical examination and consideration of imaging for stage IIB-IIIC every 3-12 mo with no distinction between stages. Detection of recurrence is important as novel systemic therapies and surgical resection of recurrence may provide survival benefits...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28619843/stefania-jablonska
#6
Ned Stafford
No abstract text is available yet for this article.
June 15, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28613820/protein-modification-by-endogenously-generated-lipid-electrophiles-mitochondria-as-the-source-and-target
#7
William N Beavers, Kristie L Rose, James J Galligan, Michelle M Mitchener, Carol A Rouzer, Keri A Tallman, Connor R Lamberson, Xiaojing Wang, Salisha Hill, Pavlina T Ivanova, H Alex Brown, Bing Zhang, Ned A Porter, Lawrence J Marnett
Determining the impact of lipid electrophile-mediated protein damage that occurs during oxidative stress requires a comprehensive analysis of electrophile targets adducted under pathophysiological conditions. Incorporation of ω-alkynyl linoleic acid into the phospholipids of macrophages prior to activation by Kdo2-lipid A, followed by protein extraction, click chemistry and streptavidin affinity capture, enabled a systems-level survey of proteins adducted by lipid electrophiles generated endogenously during the inflammatory response...
June 14, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28613096/emergency-department-visits-by-pediatric-patients-sustained-as-a-passenger-on-a-motorcycle
#8
Allison Tadros, Stephanie Owen, Shelley M Hoffman, Stephen M Davis, Melinda J Sharon
OBJECTIVE: Currently only five out of the fifty states in the United States (U.S.) have laws restricting the age of passengers permitted to ride on a motorcycle. This study sought to characterize the visits by patients under the age of 16 to US emergency departments (ED) for injuries sustained as a passenger on a motorcycle. METHODS: In this retrospective cohort study, data were obtained from the Nationwide Emergency Department Sample (NEDS) for the years 2006 to 2011...
June 14, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28611168/rapid-development-and-recurrence-of-translocation-renal-cell-carcinoma
#9
Ned Kinnear, Sam Wreghitt, Derek Barry Hennessey, Peter Liodakis
Translocation renal cell carcinoma (RCC) is a rare aggressive malignancy in adults. A 40-year-old man presented with painless macroscopic haematuria. Initial investigations of renal ultrasound, CT scan, urine culture and urine cytology were normal. On rigid cystoscopy and pyelo-ureteroscopy, bleeding was seen from a normal-appearing right renal upper pole. An arteriovenous malformation was suspected, and laser cautery was performed. Left renal biopsy was performed due to proteinuria and suggested IgA nephropathy...
June 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28602789/age-associated-and-deslorelin-induced-declines-in-serum-anti-m%C3%A3-llerian-hormone-concentrations-in-female-cheetahs-acinonyx-jubatus
#10
Ned J Place, Adrienne E Crosier, Pierre Comizzoli, Jennifer B Nagashima, Holly Haefele, Anne Schmidt-Küntzel, Laurie L Marker
Anti-Müllerian hormone (AMH) is widely used in human medicine to non-invasively estimate the size of the ovarian follicle reserve and to predict the ovarian response to gonadotropin stimulation in the context of assisted reproductive technologies (e.g., IVF). These applications of AMH testing have recently expanded to non-human mammals, with production animals, such as cows, goats and sheep being the primary focus of AMH research. However, few investigations have involved exotic species, and in particular carnivores...
June 8, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28601659/endometrioid-endometrial-carcinomas-with-melf-type-of-myoinvasion-role-of-immunohistochemistry-in-the-detection-of-occult-lymph-node-metastases-and-their-clinical-significance
#11
Iñigo Espinosa, Neus Serrat, Gian Franco Zannoni, Ramón Rovira, Emanuela D'Angelo, Jaime Prat
In endometrioid endometrial carcinomas (EEC), MELF (microcystic, elongated and fragmented) myoinvasion is associated with easily overlooked lymph node metastases; however, the role of immunohistochemistry in their detection and their clinical significance have not been addressed. We identified MELF in 43 of 101 (43%) myoinvasive EECs. Nodes were removed in 49 (49%), 25 with MELF and 24 without MELF. Metastases were initially reported in 3 of the former (12%) and 2 of the latter (8%). All negative nodes were reviewed and cytokeratin immunohistochemistry was performed...
June 7, 2017: Human Pathology
https://www.readbyqxmd.com/read/28600473/human-papillomavirus-dna-methylation-predicts-response-to-treatment-using-cidofovir-and-imiquimod-in-vulval-intraepithelial-neoplasia-3
#12
Sadie Esme Fleur Jones, Samantha Hibbitts, Christopher N Hurt, Dean Bryant, Alison N Fiander, Ned G Powell, Amanda J Tristram
Purpose <p>Response rates to treatment of vulval intraepithelial neoplasia (VIN) with imiquimod and cidofovir are approximately 57% and 61% respectively. Treatment is associated with significant side effects and, if ineffective, risk of malignant progression. Treatment response is not predicted by clinical factors. Identification of a biomarker that could predict response is an attractive prospect. This work investigated HPV DNA methylation as a potential predictive biomarker in this setting.</p> <p>Experimental design</p> <p>DNA from 167 cases of VIN 3 from the RT3 VIN clinical trial was assessed...
June 9, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28593617/the-dangers-of-extreme-body-mass-index-values-in-patients-with-clostridium-difficile
#13
Brian H Nathanson, Thomas L Higgins, William T McGee
PURPOSE: To examine the association between body mass index (BMI) and in-hospital mortality in patients presenting with Clostridium difficile infections in emergency department visits (ED) in the USA. Infected patients with extreme BMIs may have an elevated mortality risk, but prior studies examining this question have been too small to reach definitive conclusions. METHODS: Data were from the Nationwide Emergency Department Sample (NEDS), Healthcare Cost and Utilization Project (HCUP), Agency for Healthcare Research and Quality during 2012...
June 7, 2017: Infection
https://www.readbyqxmd.com/read/28585793/prevalence-and-factors-associated-with-second-eye-cataract-surgery-and-the-trend-in-the-time-interval-between-the-two-eye-surgeries-based-on-the-malaysian-national-eye-database
#14
Shu Fen Ho, Tassha Hilda Bin Adnan, Pik Pin Goh
PURPOSE: To study the prevalence of second eye cataract surgery (SECS), trend in time interval between subsequent surgeries over the years, and factors associated with SECSutilization among patients who underwent cataract surgeries in the Ministry of Health (MOH), Malaysia. DESIGN: Secondary cross-sectional analysis of the Malaysian National Eye Database (NED) data. METHODS: The Malaysian Cataract Surgery Registry collected data on patients who had cataract surgery from 2002-2004 and 2007-2012...
June 1, 2017: Asia-Pacific Journal of Ophthalmology
https://www.readbyqxmd.com/read/28574961/modifications-in-acute-phase-and-complement-systems-predict-shifts-in-cognitive-status-of-hiv-infected-patients
#15
Ceereena Ubaida-Mohien, Benjamin Lamberty, Alex M Dickens, Michelle M Mielke, Thomas Marcotte, Ned Sacktor, Igor Grant, Scott Letendre, Donald Franklin, Pawel Cibrowski, Ravi Tharakan, Justin C McArthur, Howard Fox, Norman J Haughey
BACKGROUND: The prevalence of HIV-associated neurocognitive disorders (HAND) has not changed considerably in the last two decades. Potent antiretroviral therapy has shifted the severity of HAND to milder phenotypes, but excess morbidity and mortality continue to be associated with HAND. Changes in numerous markers of immune function, inflammation, and cellular stress have been repeatedly associated with HAND, but the underlying systems that drive these changes have not been identified...
June 19, 2017: AIDS
https://www.readbyqxmd.com/read/28557557/subsequent-surgery-after-revision-anterior-cruciate-ligament-reconstruction-rates-and-risk-factors-from-a-multicenter-cohort
#16
David Y Ding, Alan L Zhang, Christina R Allen, Allen F Anderson, Daniel E Cooper, Thomas M DeBerardino, Warren R Dunn, Amanda K Haas, Laura J Huston, Brett Brick A Lantz, Barton Mann, Kurt P Spindler, Michael J Stuart, Rick W Wright, John P Albright, Annunziato Ned Amendola, Jack T Andrish, Christopher C Annunziata, Robert A Arciero, Bernard R Bach, Champ L Baker, Arthur R Bartolozzi, Keith M Baumgarten, Jeffery R Bechler, Jeffrey H Berg, Geoffrey A Bernas, Stephen F Brockmeier, Robert H Brophy, Charles A Bush-Joseph, J Brad Butler, John D Campbell, James L Carey, James E Carpenter, Brian J Cole, Jonathan M Cooper, Charles L Cox, R Alexander Creighton, Diane L Dahm, Tal S David, David C Flanigan, Robert W Frederick, Theodore J Ganley, Elizabeth A Garofoli, Charles J Gatt, Steven R Gecha, James Robert Giffin, Sharon L Hame, Jo A Hannafin, Christopher D Harner, Norman Lindsay Harris, Keith S Hechtman, Elliott B Hershman, Rudolf G Hoellrich, Timothy M Hosea, David C Johnson, Timothy S Johnson, Morgan H Jones, Christopher C Kaeding, Ganesh V Kamath, Thomas E Klootwyk, Bruce A Levy, C Benjamin Ma, G Peter Maiers, Robert G Marx, Matthew J Matava, Gregory M Mathien, David R McAllister, Eric C McCarty, Robert G McCormack, Bruce S Miller, Carl W Nissen, Daniel F O'Neill, Brett D Owens, Richard D Parker, Mark L Purnell, Arun J Ramappa, Michael A Rauh, Arthur C Rettig, Jon K Sekiya, Kevin G Shea, Orrin H Sherman, James R Slauterbeck, Matthew V Smith, Jeffrey T Spang, Steven J Svoboda, Timothy N Taft, Joachim J Tenuta, Edwin M Tingstad, Armando F Vidal, Darius G Viskontas, Richard A White, James S Williams, Michelle L Wolcott, Brian R Wolf, James J York
BACKGROUND: While revision anterior cruciate ligament reconstruction (ACLR) can be performed to restore knee stability and improve patient activity levels, outcomes after this surgery are reported to be inferior to those after primary ACLR. Further reoperations after revision ACLR can have an even more profound effect on patient satisfaction and outcomes. However, there is a current lack of information regarding the rate and risk factors for subsequent surgery after revision ACLR. PURPOSE: To report the rate of reoperations, procedures performed, and risk factors for a reoperation 2 years after revision ACLR...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28546504/ion-lazarevich-degen
#17
Ned Stafford
No abstract text is available yet for this article.
May 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28544299/mini-pcnl-for-renal-calculi-does-size-matter
#18
Derek B Hennessey, Ned K Kinnear, Andrew Troy, David Angus, Damien M Bolton, David R Webb
OBJECTIVE: To evaluate the minimally invasive percutaneous nephrolithotomy (MIP) system for renal calculi. PATIENTS AND METHODS: Consecutive patients undergoing mini-percutaneous nephrolithotomy (mPCNL) procedures with the MIP system were enrolled. Patient position, American Society of Anesthesiologists classification, puncture location, stone clearance, postoperative drainage and complications were recorded, and features unique to MIP were noted. RESULTS: In all, 30 patients underwent 32 mPCNL procedures...
May 2017: BJU International
https://www.readbyqxmd.com/read/28539669/sensorimotor-adaptation-as-a-behavioural-biomarker-of-early-spinocerebellar-ataxia-type-6
#19
Muriel T N Panouillères, Raed A Joundi, Sonia Benitez-Riveiro, Binith Cheeran, Christopher R Butler, Andrea H Németh, R Chris Miall, Ned Jenkinson
Early detection of the behavioural deficits of neurodegenerative diseases may help to describe the pathogenesis of such diseases and establish important biomarkers of disease progression. The aim of this study was to identify how sensorimotor adaptation of the upper limb, a cerebellar-dependent process restoring movement accuracy after introduction of a perturbation, is affected at the pre-clinical and clinical stages of spinocerebellar ataxia type 6 (SCA6), an inherited neurodegenerative disease. We demonstrate that initial adaptation to the perturbation was significantly impaired in the eighteen individuals with clinical motor symptoms but mostly preserved in the five pre-clinical individuals...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28528985/atrial-fibrillation-and-risk-of-hip-fracture-a-population-based-analysis-of-113-600-individuals
#20
Christopher X Wong, Siang Wei Gan, Sarah W Lee, Celine Gallagher, Ned J Kinnear, Dennis H Lau, Rajiv Mahajan, Kurt C Roberts-Thomson, Prashanthan Sanders
BACKGROUND: A number of cardiovascular diseases have been linked with bone health and an increased risk of osteoporotic fracture. Whether atrial fibrillation (AF) is associated with subsequent fracture risk is not known. METHODS: Administrative, clinical and hospitalisation information were linked over a 14-year period. From this longitudinal, population-based dataset of 113,600 individuals, time-dependent exposures using multivariate Cox proportional hazards regression models were employed to determine incidence rates and hazard ratios (HR) for hip fracture according to a history of AF...
May 5, 2017: International Journal of Cardiology
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