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https://www.readbyqxmd.com/read/29762177/neuropsychological-phenotypes-among-men-with-and-without-hiv-disease-in-the-multicenter-aids-cohort-study
#1
Samantha A Molsberry, Yu Cheng, Lawrence Kingsley, Lisa Jacobson, Andrew J Levine, Eileen Martin, Eric N Miller, Cynthia A Munro, Ann Ragin, Ned Sacktor, James T Becker
OBJECTIVE: Mild forms of HIV-associated neurocognitive disorder (HAND) remain prevalent in the combination anti-retroviral therapy (cART) era. This study's objective was to identify neuropsychological subgroups within the Multicenter AIDS Cohort Study (MACS) based on the participant-based latent structure of cognitive function and to identify factors associated with subgroups. DESIGN: The MACS is a four-site longitudinal study of the natural and treated history of HIV disease among gay and bisexual men...
May 11, 2018: AIDS
https://www.readbyqxmd.com/read/29758653/hidden-long-evolutionary-memory-in-a-model-biochemical-network
#2
Md Zulfikar Ali, Ned S Wingreen, Ranjan Mukhopadhyay
We introduce a minimal model for the evolution of functional protein-interaction networks using a sequence-based mutational algorithm, and apply the model to study neutral drift in networks that yield oscillatory dynamics. Starting with a functional core module, random evolutionary drift increases network complexity even in the absence of specific selective pressures. Surprisingly, we uncover a hidden order in sequence space that gives rise to long-term evolutionary memory, implying strong constraints on network evolution due to the topology of accessible sequence space...
April 2018: Physical Review. E
https://www.readbyqxmd.com/read/29756611/cochlear-obliteration-following-a-translabyrinthine-approach-and-its-implications-in-cochlear-implantation
#3
B Delgado-Vargas, M Medina, R Polo, A Lloris, M Vaca, C Pérez, A Cordero, I Cobeta
The most frequent sequelae following a translabyrinthine approach for vestibular schwannoma resection is complete hearing loss on the affected side. Such patients could benefit from a cochlear implant, provided that two essential requisites are met before surgery: a preserved cochlear nerve and a patent cochlea to accommodate the electrode array. The goal of our study is to determine the prevalence and extent of cochlear ossification following a translabyrinthine approach. Postoperative MRI of 41 patients were retrospectively reviewed...
February 2018: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29750945/ocular-injury-in-united-states-emergency-departments-seasonality-and-annual-trends-estimated-from-a-nationally-representative-dataset
#4
David A Ramirez, Travis C Porco, Thomas M Lietman, Jeremy D Keenan
PURPOSE: To determine whether ocular trauma occurs more frequently in the summer months. DESIGN: Retrospective, cross-sectional study. METHODS: The Nationwide Emergency Department Sample (NEDS) is a large, publicly available administrative database that provides nationally representative estimates of emergency department (ED) visits in the United States. Billing codes from NEDS from 2006 to 2013 were used to identify all cases of ocular trauma, and the United States decennial census was used to estimate the population at risk for visiting an ED...
May 8, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29750814/one-year-mortality-after-recovery-from-critical-illness-a-retrospective-cohort-study
#5
Sharukh Lokhandwala, Ned McCague, Abdullah Chahin, Braiam Escobar, Mengling Feng, Mohammad M Ghassemi, David J Stone, Leo Anthony Celi
RATIONALE: Factors associated with one-year mortality after recovery from critical illness are not well understood. Clinicians generally lack information regarding post-hospital discharge outcomes of patients from the intensive care unit, which may be important when counseling patients and families. OBJECTIVE: We sought to determine which factors among patients who survived for at least 30 days post-ICU admission are associated with one-year mortality. METHODS: Single-center, longitudinal retrospective cohort study of all ICU patients admitted to a tertiary-care academic medical center from 2001-2012 who survived ≥30 days from ICU admission...
2018: PloS One
https://www.readbyqxmd.com/read/29746918/circulating-tumor-cells-in-stage-iv-melanoma-patients
#6
Carolyn S Hall, Merrick Ross, Jessica B Bowman Bauldry, Joshua Upshaw, Mandar G Karhade, Richard Royal, Sapna Patel, Anthony Lucci
BACKGROUND: Management of stage IV melanoma patients remains a challenge. In spite of promising new therapies, many patients develop resistance and progression. The aim of this pilot study was to determine if CTCs are associated with shortened (180-day) progression-free survival (PFS) following a baseline CTC assessment in stage IV melanoma patients. METHODS: A baseline CTC assessment was performed in 93 stage IV melanoma patients using a commercially available immunomagnetic system...
May 7, 2018: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29746300/impact-of-glycemic-status-on-longitudinal-cognitive-performance-in-men-with-and-without-hiv-infection
#7
Jingyan Yang, Lisa P Jacobson, James T Becker, Andrew Levine, Eileen M Martin, Cynthia A Munro, Frank J Palella, Jordan E Lake, Ned C Sacktor, Todd T Brown
OBJECTIVES: To determine the relationship between glycemic status and cognitive performance in men living with (MLWH) and without HIV infection. DESIGN: A prospective HIV/AIDS cohort study in four U.S. cities between 1999 and 2016. METHODS: Glycemic status was categorized as normal glucose (NG), impaired fasting glucose (IFG), controlled diabetes mellitus (DM) and uncontrolled DM at each semi-annual visit. Cognitive performance was evaluated using nine neuropsychological tests which measure attention, constructional ability, verbal learning, executive functioning, memory, and psychomotor speed...
May 8, 2018: AIDS
https://www.readbyqxmd.com/read/29746297/microglial-activation-is-inversely-associated-with-cognition-in-individuals-living-with-hiv-on-effective-antiretroviral-therapy
#8
Leah H Rubin, Ned Sacktor, Jason Creighton, Yong Du, Christopher J Endres, Martin G Pomper, Jennifer M Coughlin
OBJECTIVE: Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signaling by cells of the myeloid-lineage. Here we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g., frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function. DESIGN: 21 HIV+VS individuals underwent positron emission tomography (PET) with [C]DPA-713 to image the translocator protein 18 KDa (TSPO), a marker of microglial activation, and completed a comprehensive neuropsychological test battery...
May 9, 2018: AIDS
https://www.readbyqxmd.com/read/29736318/androgen-receptor-signaling-regulates-t-type-ca-2-channel-expression-and-neuroendocrine-differentiation-in-prostate-cancer-cells
#9
Megan Hall, Bryan Todd, Edwin D Allen, Nga Nguyen, Yoon-Jung Kwon, Vu Nguyen, Jennifer L Hearne, Miguel Martin-Caraballo
Therapies designed to reduce androgen production or receptor activation are effective in limiting prostate tumor growth. However, prolonged treatment with anti-androgen therapies results in the progression of prostate cancers into an androgen refractory state. Neuroendocrine differentiation (NED) has been associated with the progression of prostate cancers to an androgen resistant phenotype. In this work we investigated the effect of disrupting androgen receptor signaling in promoting NED of prostate carcinoma cells and whether it is accompanied by an increase in T-type Ca2+ channel expression...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29734348/the-impact-of-tackle-football-injuries-on-the-american-healthcare-system-with-a-neurological-focus
#10
Michael J McGinity, Ramesh Grandhi, Joel E Michalek, Jesse S Rodriguez, Aron M Trevino, Ashley C McGinity, Ali Seifi
BACKGROUND: Recent interest in the study of concussion and other neurological injuries has heightened awareness of the medical implications of American tackle football injuries amongst the public. OBJECTIVE: Using the National Emergency Department Sample (NEDS) and the National Inpatient Sample (NIS), the largest publicly available all-payer emergency department and inpatient healthcare databases in the United States, we sought to describe the impact of tackle football injuries on the American healthcare system by delineating injuries, specifically neurological in nature, suffered as a consequence of tackle football between 2010 and 2013...
2018: PloS One
https://www.readbyqxmd.com/read/29733281/characterization-of-viscoelastic-materials-using-group-shear-wave-speeds
#11
Ned C Rouze, Yufeng Deng, Courtney A Trutna, Mark L Palmeri, Kathryn R Nightingale
Recent investigations of viscoelastic properties of materials have been performed by observing shear wave propagation following localized, impulsive excitations, and Fourier decomposing the shear wave signal to parameterize the frequency-dependent phase velocity using a material model. This paper describes a new method to characterize viscoelastic materials using group shear wave speeds , , and determined from the shear wave displacement, velocity, and acceleration signals, respectively. Materials are modeled using a two-parameter linear attenuation model with phase velocity and dispersion slope at a reference frequency of 200 Hz...
May 2018: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/29728362/q-a-ned-sharpless-on-his-vision-for-nci
#12
(no author information available yet)
Norman "Ned" Sharpless, MD, NCI's new director, talks about how he plans to bolster four areas of the agency's enterprise to accelerate progress in the treatment of cancer: workforce training and development, basic science, "big data," and clinical trials.
May 4, 2018: Cancer Discovery
https://www.readbyqxmd.com/read/29728311/expression-of-neuroendocrine-differentiation-markers-in-lethal-metastatic-castration-resistant-prostate-cancer
#13
Miika Sainio, Tapio Visakorpi, Teemu Tolonen, Joanna Ilvesaro, G Steven Bova
Neuroendocrine differentiation (NED) is a common phenomenon in prostate cancer, and it has been associated with poor prognosis in some studies of primary prostate cancer. Incidence and patterns of NED in metastatic prostate cancer sites have not been examined widely. In this study, we studied expression of three commonly used markers of NED (chromogranin A, neuron specific enolase and synaptophysin) in 89 metastases from 31 men that died of castration-resistant prostate cancer and underwent rapid autopsy, and in 89 hormone-naïve primary tumors removed by radical prostatectomy...
April 26, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29726092/intra-operative-cell-salvage-in-urological-surgery-a-systematic-review-and-meta-analysis-of-comparative-studies
#14
REVIEW
Ned Kinnear, Michael O'Callaghan, Derek Hennessey, Heath Liddell, Bradley Newell, John Bolt, A/Prof Nathan Lawrentschuk
OBJECTIVE: To systematically evaluate the safety and efficacy of intra-operative cell salvage (ICS) in urology. METHODS: A search of Medline, Embase and Cochrane Library to August 2017 was performed using methods pre-published on PROSPERO. Reporting followed the Preferred Reporting Items for Systematic Review and Meta-analysis guidelines. Eligible titles were comparative studies published in English utilising ICS in urology. Primary outcomes were allogeneic transfusion rates (ATR) and tumour recurrence...
May 3, 2018: BJU International
https://www.readbyqxmd.com/read/29723142/use-of-a-novel-foam-dressing-with-negative-pressure-wound-therapy-and-instillation-recommendations-and-clinical-experience
#15
Paul J Kim, Andrew Applewhite, Anthony N Dardano, Luis Fernandez, Kimberly Hall, Elizabeth McElroy, Susan Mendez-Eastman, Marie Anne Obst, Casey Thomas, Lindsey Waddell, Garrett Wirth, Luc Téot
A new reticulated open-cell foam dressing with through holes (ROCF-CC) has been introduced to assist with wound cleansing by removing thick wound exudate and infectious materials during neg- ative pressure wound therapy with instillation. Due to the limited published evidence supporting use of ROCF-CC dressings with negative pressure wound therapy with instillation and dwell time (NPWTi-d), clinicians have been relying on practical application experience to gain pro ciency with the dressing and NPWTi-d. To help provide general guidelines for safe and e cient use of ROCF-CC dressings with NPWTi-d, a multidisciplinary expert panel of clinicians was convened from September 28 to 29, 2017...
March 2018: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/29721191/microrna-652-induces-ned-in-lncap-and-emt-in-pc3-prostate-cancer-cells
#16
Robert K Nam, Tania Benatar, Yutaka Amemiya, Christopher J D Wallis, Joan Miguel Romero, Melina Tsagaris, Christopher Sherman, Linda Sugar, Arun Seth
MicroRNAs (miRNAs) are small noncoding RNA molecules that post-transcriptionally regulate gene expression. Dysregulation of miRNAs is frequently associated with disease and, in particular, is involved in prostate cancer progression. Next generation miRNA sequencing identified a panel of five miRNAs associated with prostate cancer recurrence and metastasis. High expression of one of these five miRNAs, miR-652, correlated significantly with an increased rate of prostate cancer biochemical recurrence. Overexpression of miR-652 in prostate cancer cells, PC3 and LNCaP, resulted in increased growth, migration and invasion...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29712974/author-correction-sensorimotor-adaptation-as-a-behavioural-biomarker-of-early-spinocerebellar-ataxia-type-6
#17
Muriel T N Panouillères, Raed A Joundi, Sonia Benitez-Rivero, Binith Cheeran, Christopher R Butler, Andrea H Németh, R Chris Miall, Ned Jenkinson
A correction has been published and is appended to both the HTML and PDF versions of this paper. The error has been fixed in the paper.
April 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29712710/austrian-doctors-secure-potential-reprieve-for-scrapped-smoking-ban
#18
Ned Stafford
No abstract text is available yet for this article.
April 30, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29700099/effect-of-a549-neuroendocrine-differentiation-on-cytotoxic-immune-response
#19
Irasema Mendieta, Rosa-Elvira Nunez-Anita, Gilberto Pérez-Sánchez, Lenin Pavon, Alfredo Rodríguez-Cruz, Guadalupe Garcia-Alcocer, Laura Cristina Berumen
The present study was designed to determine the effects of factors secreted by the lung adenocarcinoma cell line with the neuroendocrine phenotype, A549NED, on cytotoxic T lymphocytes (CTL) activity in vitro. A perspective that integrates the nervous, endocrine and immune system in cancer research is essential to understand the complexity of dynamic interactions in tumours. Extensive clinical research suggests that neuroendocrine differentiation (NED) is correlated with worse patient outcomes; however, little is known regarding the effects of neuroendocrine factors on the communication between the immune system and neoplastic cells...
April 26, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29698737/dichlorophenyl-piperazines-including-a-recently-approved-atypical-antipsychotic-are-potent-inhibitors-of-dhcr7-the-last-enzyme-in-cholesterol-biosynthesis
#20
Thiago C Genaro-Mattos, Keri A Tallman, Luke B Allen, Allison Anderson, Karoly Mirnics, Zeljka Korade, Ned A Porter
While antipsychotic medications provide important relief from debilitating psychotic symptoms, they also have significant adverse side effects, which might have relevant impact on human health. Several research studies, including ours, have shown that commonly used antipsychotics such as haloperidol and aripiprazole affect cholesterol biosynthesis at the conversion of 7-dehydrocholesterol (7-DHC) to cholesterol. This transformation is promoted by the enzyme DHCR7 and its inhibition causes increases in plasma and tissue levels of 7-DHC...
April 23, 2018: Toxicology and Applied Pharmacology
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