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https://www.readbyqxmd.com/read/28928292/elastomer-change-out-justification-for-minimizing-the-removal-of-elastomers-in-order-to-prevent-cross-contamination-in-a-multiproduct-facility
#1
Michael Parks, Niamh O'Dwyer, Jeremy Bollinger, Alan Johnson, Brian Goss, Ned Wyman, Adeyma Arroyo, Joseph Wood, Derek Willison-Parry
The primary objective of any Biopharmaceutical Product Changeover (PCO) program is to employ control strategies before, during, and after the manufacturing process, as well as from the beginning of the lifecycle approach for the equipment and validation, which will minimize the opportunity for cross- contamination when switching between products. Evaluation of the need for an Elastomer Change Out (ECO) should be considered as a segment of an overall changeover assessment. Lifecycle systems (e.g. Preventive Maintenance (PM), Cleanability Coupon Testing, Good Engineering Practices, etc...
September 19, 2017: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/28917536/birth-outcomes-following-immunization-of-pregnant-women-with-pandemic-h1n1-influenza-vaccine-2009-2010
#2
Abigail Eaton, Ned Lewis, Bruce Fireman, John Hansen, Roger Baxter, Julianne Gee, Nicola P Klein
BACKGROUND: Following the H1N1 influenza pandemic in 2009, pregnant women were recommended to receive both seasonal (TIV) and H1N1 influenza vaccines. This study presents incidence of adverse birth and pregnancy outcomes among a population of pregnant women immunized with TIV and H1N1 vaccines at Kaiser Permanente Northern California during 2009-2010. METHODS: We telephone surveyed pregnant Kaiser Permanente Northern California members to assess non-medically-attended reactions following H1N1, TIV or both vaccines during 2009-2010 (n=5365) in a separate study...
September 13, 2017: Vaccine
https://www.readbyqxmd.com/read/28914750/live-attenuated-influenza-vaccination-prior-to-age-3-years-and-subsequent-development-of-asthma-a-14-year-follow-up-study
#3
Roger P Baxter, Ned Lewis, Bruce Fireman, John Hansen, Nicola P Klein, Justin R Ortiz
BACKGROUND: Live-attenuated influenza vaccines (LAIVs) are not licensed in children <2 years because of a wheezing safety signal that has not been fully elucidated. In 2000, the Kaiser Permanente Vaccine Study Center conducted a placebo controlled randomized clinical trial (RCT) of LAIV in children. As many of these children were still enrolled in Kaiser Permanente in 2014, we could assess the possible long-term association between LAIV and subsequent asthma diagnosis. METHODS: We identified all children who were originally enrolled into the LAIV RCT at < 3 years of age...
September 12, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28913157/non-functioning-gastroenteropancreatic-gep-tumors-a-111-in-pentetreotide-spect-ct-diagnostic-study
#4
Angela Spanu, Orazio Schillaci, Bastiana Piras, Diego F Calvisi, Antonio Falchi, Roberta Danieli, Susanna Nuvoli, Franca Dore, Giuseppe Madeddu
In a retrospective study performed in non-functioning GEP tumor patients we further investigated (111)In-Pentetreotide SPECT/CT usefulness in diagnosis, staging and follow-up also evaluating whether the procedure may give more information than conventional imaging procedures (CIP), such as CT, MRI, US. We enrolled 104 consecutive patients with non-functioning GEP tumors, 30 in initial diagnosis and staging phases (IDS) and 74 in follow-up (FU). All patients underwent somatostatin receptor scintigraphy (SRS) whole body scan at 4, 24 and, if necessary, 48 hours followed by abdominal and chest SPECT/CT after (111)In-Pentetreotide 148-222 MBq i...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28905622/proton-diffusion-through-bilayer-pores
#5
Jesse Gatten McDaniel, Arun Yethiraj
The transport of protons through channels in complex environments is important in biology and materials science. In this work, we use multistate empirical valence bond simulations to study proton transport within a well-defined bilayer pore in a lamellar Lβ phase lyotropic liquid crystal (LLC). The LLC is formed from the self-assembly of dicarboxylate gemini surfactants in water, and a bilayer-spanning pore of ∼3-5 A radius results from the uneven partitioning of surfactants between the two leaflets of the lamella...
September 14, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28905415/hyperactive-mtor-induces-neuroendocrine-differentiation-in-prostate-cancer-cell-with-concurrent-up-regulation-of-irf1
#6
Mayuko Kanayama, Toshiya Hayano, Michinori Koebis, Tatsuya Maeda, Yoko Tabe, Shigeo Horie, Atsu Aiba
BACKGROUND: Neuroendocrine-differentiated prostate cancer (NEPCa) is refractory to androgen deprivation therapy and shows a poor prognosis. The underlying mechanisms responsible for neuroendocrine differentiation (NED) are yet to be clarified. In this study, we investigated the role of mammalian target of rapamycin (mTOR) in NEPCa. METHODS: We utilized a gain-of-function analysis by establishing a human PCa LNCaP stable line that expresses hyperactive mTOR (LNCaP-mTOR)...
September 14, 2017: Prostate
https://www.readbyqxmd.com/read/28901808/morphometric-characteristics-and-coi-haplotype-diversity-of-arctodiaptomus-spinosus-copedoda-populations-in-soda-pans-in-hungary
#7
László Forró, Judit Nédli, Enikő Csata, Virág Krízsik, Csilla Balogh, László G-Tóth
Arctodiaptomus spinosus (Daday, 1891) is a characteristic species of the soda pan zooplankton in the Great Hungarian Plain. The biogeographical distribution of the species is interesting, since its range expands from the Pannonian Biogeographic region to the other side of the Carpathians, occurring in saline lakes in Eastern Anatolia, Armenia, Iran and in temporary waters in Ukraine. Our investigations focused on the morphometric characteristics and the COI haplotype diversity of four Hungarian populations in the Kiskunság area...
September 2017: Acta Biologica Hungarica
https://www.readbyqxmd.com/read/28899381/ned-19-inhibition-of-parasite-growth-and-multiplication-suggests-a-role-for-naadp-mediated-signalling-in-the-asexual-development-of-plasmodium-falciparum
#8
Pablo Suárez-Cortés, Guido Gambara, Annarita Favia, Fioretta Palombi, Pietro Alano, Antonio Filippini
BACKGROUND: Although malaria is a preventable and curable human disease, millions of people risk to be infected by the Plasmodium parasites and to develop this illness. Therefore, there is an urgent need to identify new anti-malarial drugs. Ca(2+) signalling regulates different processes in the life cycle of Plasmodium falciparum, representing a suitable target for the development of new drugs. RESULTS: This study investigated for the first time the effect of a highly specific inhibitor of nicotinic acid adenine dinucleotide phosphate (NAADP)-induced Ca(2+) release (Ned-19) on P...
September 12, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28895797/neuroendocrine-disruption-of-organizational-and-activational-hormone-programming-in-poikilothermic-vertebrates
#9
REVIEW
Cheryl S Rosenfeld, Nancy D Denslow, Edward F Orlando, Juan Manuel Gutierrez-Villagomez, Vance L Trudeau
In vertebrates, sexual differentiation of the reproductive system and brain is tightly orchestrated by organizational and activational effects of endogenous hormones. In mammals and birds, the organizational period is typified by a surge of sex hormones during differentiation of specific neural circuits; whereas activational effects are dependent upon later increases in these same hormones at sexual maturation. Depending on the reproductive organ or brain region, initial programming events may be modulated by androgens or require conversion of androgens to estrogens...
2017: Journal of Toxicology and Environmental Health. Part B, Critical Reviews
https://www.readbyqxmd.com/read/28886698/screening-for-anxiety-and-depression-reassessing-the-utility-of-the-zung-scales
#10
Debra A Dunstan, Ned Scott, Anna K Todd
BACKGROUND: While the gold standard for the diagnosis of mental disorders remains the structured clinical interview, self-report measures continue to play an important role in screening and measuring progress, as well as being frequently employed in research studies. Two widely-used self-report measures in the area of depression and anxiety are Zung's Self-Rating Depression Scale (SDS) and Self Rating Anxiety Scale (SAS). However, considerable confusion exists in their application, with clinical cut-offs often applied incorrectly...
September 8, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28874213/differences-in-neurocognitive-impairment-among-hiv-infected-latinos-in-the-united-states
#11
María J Marquine, Anne Heaton, Neco Johnson, Monica Rivera-Mindt, Mariana Cherner, Cinnamon Bloss, Todd Hulgan, Anya Umlauf, David J Moore, Pariya Fazeli, Susan Morgello, Donald Franklin, Scott Letendre, Ron Ellis, Ann C Collier, Christina M Marra, David B Clifford, Benjamin B Gelman, Ned Sacktor, David Simpson, J Allen McCutchan, Igor Grant, Robert K Heaton
OBJECTIVES: Human immunodeficiency virus (HIV) disproportionately affects Hispanics/Latinos in the United States, yet little is known about neurocognitive impairment (NCI) in this group. We compared the rates of NCI in large well-characterized samples of HIV-infected (HIV+) Latinos and (non-Latino) Whites, and examined HIV-associated NCI among subgroups of Latinos. METHODS: Participants included English-speaking HIV+ adults assessed at six U.S. medical centers (194 Latinos, 600 Whites)...
September 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28869118/multicentric-giant-cell-tumor-of-bone-case-series-of-4-patients
#12
Munehisa Kito, Seiichi Matsumoto, Keisuke Ae, Taisuke Tanizawa, Tabu Gokita, Keiko Hayakawa, Yuki Funauchi, Yutaka Takazawa
BACKGROUND: We aimed to retrospectively investigate patients with multicentric giant cell tumor (MCGCT) who were treated at our hospital and to clarify their clinical features, treatment policy, and follow-up method. METHODS: Four patients with two or more giant cell tumor (GCT) that occurred in the same patient were treated at our institution between 1978 and 2015. These patients were evaluated for the following: frequency, age of onset, number and site of occurrence, time to occurrence of the next lesion, treatment, recurrence, malignant transformation, metastasis, and oncological outcome...
August 28, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28863362/the-location-of-late-night-bars-and-alcohol-related-crashes-in-houston-texas
#13
Ned Levine
A study in the City of Houston, Texas, related the location of establishments primarily serving alcohol ("bars") after midnight to late night alcohol-related motor vehicle crashes. There were three data sets for 2007-09: 1) 764bars that were open after midnight; 2) 1660 alcohol-related crashes that occurred within the City of Houston between midnight and 6 am; and 3) 4689 modeling network road segments to which bars and alcohol-related crashes were assigned. Forty-five percent of the late night alcohol-related crashes were within a quarter mile of a late night bar...
August 29, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28845301/limited-evidence-that-the-presence-of-a-bone-bruise-alone-affects-the-clinical-outcome-of-surgically-reconstructed-anterior-cruciate-ligaments-a-systematic-review
#14
Brian E Walczak, Cody Lukes, Ned Amendola, Warren R Dunn
IMPORTANCE: Anterior cruciate ligament (ACL) injury can be a devastating injury that without surgery may lead to chronic instability. Although surgical reconstruction recreates the stabilising constraint of the native ACL, postoperative pain and subsequent arthrosis may follow. OBJECTIVES: The primary objective of this systematic review is to determine whether the presence of a bone bruise following ACL rupture adversely affects the clinical outcomes following surgical reconstruction...
July 2017: Journal of ISAKOS
https://www.readbyqxmd.com/read/28841986/indirect-determination-of-pentaerythritol-tetranitrate-petn-with-a-gold-nanoparticles-based-colorimetric-sensor
#15
Ayşem Üzer, Uğur Yalçın, Ziya Can, Erol Erçağ, Reşat Apak
Pentaerythritol tetranitrate (PETN) is the nitrate ester of pentaerythritol, used as an energetic and filling material for military and civilian purposes and rarely for terrorist actions. As there is no reliable nano-colorimetric method for PETN assay, we developed an indirect method based on the determination of nitrite, obtained by reduction of nitrate derived from the alkaline hydrolysis of PETN with H2O2. We colorimetrically determined the final product, nitrite, by both conventional Griess reaction and a recently developed gold nanoparticle-4-aminothiophenol-N-(1-naphthyl)-ethylenediamine (AuNP-4-ATP+NED) method...
December 1, 2017: Talanta
https://www.readbyqxmd.com/read/28839019/draft-genome-sequence-of-the-fungus-associated-with-oak-wilt-mortality-in-south-korea-raffaelea-quercus-mongolicae-kacc44405
#16
Jongbum Jeon, Ki-Tae Kim, Hyeunjeong Song, Gir-Won Lee, Kyeongchae Cheong, Hyunbin Kim, Gobong Choi, Yong-Hwan Lee, Jane E Stewart, Ned B Klopfenstein, Mee-Sook Kim
The fungus Raffaelea quercus-mongolicae is the causal agent of Korean oak wilt, a disease associated with mass mortality of oak trees (e.g., Quercus spp.). The fungus is vectored and dispersed by the ambrosia beetle, Platypus koryoensis Here, we present the 27.0-Mb draft genome sequence of R. quercus-mongolicae strain KACC44405.
August 24, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28835649/extracellular-matrix-mediated-osmotic-pressure-drives-vibrio-cholerae-biofilm-expansion-and-cheater-exclusion
#17
Jing Yan, Carey D Nadell, Howard A Stone, Ned S Wingreen, Bonnie L Bassler
Biofilms, surface-attached communities of bacteria encased in an extracellular matrix, are a major mode of bacterial life. How the material properties of the matrix contribute to biofilm growth and robustness is largely unexplored, in particular in response to environmental perturbations such as changes in osmotic pressure. Here, using Vibrio cholerae as our model organism, we show that during active cell growth, matrix production enables biofilm-dwelling bacterial cells to establish an osmotic pressure difference between the biofilm and the external environment...
August 23, 2017: Nature Communications
https://www.readbyqxmd.com/read/28833882/change-in-care-transition-practice-for-patients-with-non-specific-chest-pain-after-ed-evaluation-2006-2012
#18
Maame Yaa A B Yiadom, Cathy A Jenkins, Christopher W Baugh, Sean P Collins, Monisha C Bhatia, Robert S Dittus, Alan B Storrow
OBJECTIVES: From 2005-2010 healthcare financing shifts in the United States may have affected care transition practices for emergency department (ED) patients with non-specific chest pain (CP) after ED evaluation. Despite being less acutely ill than those with myocardial infarction, these patients' management can be challenging. The risk of missing acute coronary syndrome is considerable enough to often warrant admission. Diagnostic advances and reimbursement limitations on the use of inpatient admission are encouraging the use of alternative ED care transition practices...
August 18, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28827280/systematic-and-quantitative-assessment-of-hydrogen-peroxide-reactivity-with-cysteines-across-human-proteomes
#19
Ling Fu, Ke-Ke Liu, Ming-An Sun, Cai-Ping Tian, Rui Sun, Carlos Morales Betanzos, Keri A Tallman, Ned A Porter, Yong Yang, Dian-Jing Guo, Daniel C Liebler, Jing Yang
Protein cysteinyl residues are the mediators of hydrogen peroxide (H2O2)-dependent redox signaling. However, site-specific mapping of the selectivity and dynamics of these redox reactions in cells poses a major analytical challenge. Here we describe a chemoproteomic platform to systematically and quantitatively analyze the reactivity of thousands of cysteines toward H2O2 in human cells. We identified >900 H2O2-sensitive cysteines, which are defined as the H2O2-dependent redoxome. Although redox sites associated with antioxidative and metabolic functions are consistent, most of the H2O2-dependent redoxome varies dramatically between different cells...
August 21, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/28826491/mechanism-of-bidirectional-thermotaxis-in-escherichia-coli
#20
Anja Paulick, Vladimir Jakovljevic, SiMing Zhang, Michael Erickstad, Alex Groisman, Yigal Meir, William S Ryu, Ned S Wingreen, Victor Sourjik
In bacteria various tactic responses are mediated by the same cellular pathway, but sensing of physical stimuli remains poorly understood. Here, we combine an in-vivo analysis of the pathway activity with a microfluidic taxis assay and mathematical modeling to investigate the thermotactic response of Escherichia coli. We show that in the absence of chemical attractants E. coli exhibits a steady thermophilic response, the magnitude of which decreases at higher temperatures. Adaptation of wild-type cells to high levels of chemoattractants sensed by only one of the major chemoreceptors leads to inversion of the thermotactic response at intermediate temperatures and bidirectional cell accumulation in a thermal gradient...
August 3, 2017: ELife
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