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https://www.readbyqxmd.com/read/28546504/ion-lazarevich-degen
#1
Ned Stafford
No abstract text is available yet for this article.
May 25, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28544299/mini-pcnl-for-renal-calculi-does-size-matter
#2
Derek B Hennessey, Ned K Kinnear, Andrew Troy, David Angus, Damien M Bolton, David R Webb
OBJECTIVE: To evaluate the minimally invasive percutaneous nephrolithotomy (MIP) system for renal calculi. PATIENTS AND METHODS: Consecutive patients undergoing mini-percutaneous nephrolithotomy (mPCNL) procedures with the MIP system were enrolled. Patient position, American Society of Anesthesiologists classification, puncture location, stone clearance, postoperative drainage and complications were recorded, and features unique to MIP were noted. RESULTS: In all, 30 patients underwent 32 mPCNL procedures...
May 2017: BJU International
https://www.readbyqxmd.com/read/28539669/sensorimotor-adaptation-as-a-behavioural-biomarker-of-early-spinocerebellar-ataxia-type-6
#3
Muriel T N Panouillères, Raed A Joundi, Sonia Benitez-Riveiro, Binith Cheeran, Christopher R Butler, Andrea H Németh, R Chris Miall, Ned Jenkinson
Early detection of the behavioural deficits of neurodegenerative diseases may help to describe the pathogenesis of such diseases and establish important biomarkers of disease progression. The aim of this study was to identify how sensorimotor adaptation of the upper limb, a cerebellar-dependent process restoring movement accuracy after introduction of a perturbation, is affected at the pre-clinical and clinical stages of spinocerebellar ataxia type 6 (SCA6), an inherited neurodegenerative disease. We demonstrate that initial adaptation to the perturbation was significantly impaired in the eighteen individuals with clinical motor symptoms but mostly preserved in the five pre-clinical individuals...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28528985/atrial-fibrillation-and-risk-of-hip-fracture-a-population-based-analysis-of-113-600-individuals
#4
Christopher X Wong, Siang Wei Gan, Sarah W Lee, Celine Gallagher, Ned J Kinnear, Dennis H Lau, Rajiv Mahajan, Kurt C Roberts-Thomson, Prashanthan Sanders
BACKGROUND: A number of cardiovascular diseases have been linked with bone health and an increased risk of osteoporotic fracture. Whether atrial fibrillation (AF) is associated with subsequent fracture risk is not known. METHODS: Administrative, clinical and hospitalisation information were linked over a 14-year period. From this longitudinal, population-based dataset of 113,600 individuals, time-dependent exposures using multivariate Cox proportional hazards regression models were employed to determine incidence rates and hazard ratios (HR) for hip fracture according to a history of AF...
May 5, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28520726/losing-a-jewel-rapid-declines-in-myanmar-s-intact-forests-from-2002-2014
#5
Tejas Bhagwat, Andrea Hess, Ned Horning, Thiri Khaing, Zaw Min Thein, Kyaw Moe Aung, Kyaw Htet Aung, Paing Phyo, Ye Lin Tun, Aung Htat Oo, Anthony Neil, Win Myo Thu, Melissa Songer, Katherine LaJeunesse Connette, Asja Bernd, Qiongyu Huang, Grant Connette, Peter Leimgruber
New and rapid political and economic changes in Myanmar are increasing the pressures on the country's forests. Yet, little is known about the past and current condition of these forests and how fast they are declining. We mapped forest cover in Myanmar through a consortium of international organizations and environmental non-governmental groups, using freely-available public domain data and open source software tools. We used Landsat satellite imagery to assess the condition and spatial distribution of Myanmar's intact and degraded forests with special focus on changes in intact forest between 2002 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28505393/the-science-behind-one-health-at-the-interface-of-humans-animals-and-the-environment
#6
Michael P Murtaugh, Clifford J Steer, Srinand Sreevatsan, Ned Patterson, Shaun Kennedy, P Sriramarao
Humans face a grand quality-of-life challenge as growing demands for resources for an ever-expanding population threaten the existence of wildlife populations, degrade land, and pollute air and water. Public investment and policy decisions that will shape future interactions of humans, animals, and the environment need scientific input to help find common ground for durable and sustainable success. The Second International Conference on One Medicine One Science brought together a broad range of scientists, trainees, regulatory authorities, and health experts from 34 countries to inform and discuss the human impacts of air quality; the complexities of water quality, access, and conflicts; the opportunities and uncertainties in precision medicine; and the role of science communication in health policy formulation...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28503143/impairments-of-motor-function-while-multitasking-in-hiv
#7
Sharif I Kronemer, Jordan A Mandel, Ned C Sacktor, Cherie L Marvel
Human immunodeficiency virus (HIV) became a treatable illness with the introduction of combination antiretroviral therapy (CART). As a result, patients with regular access to CART are expected to live decades with HIV. Long-term HIV infection presents unique challenges, including neurocognitive impairments defined by three major stages of HIV-associated neurocognitive disorders (HAND). The current investigation aimed to study cognitive and motor impairments in HIV using a novel multitasking paradigm. Unlike current standard measures of cognitive and motor performance in HIV, multitasking increases real-world validity by mimicking the dual motor and cognitive demands that are part of daily professional and personal settings (e...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28502529/mechanisms-underlying-the-early-risk-to-develop-anxiety-and-depression-a-translational-approach
#8
REVIEW
Ned H Kalin
Anxious temperament (AT) is an early life disposition that markedly increases the risk to develop stress related psychopathology such as anxiety and depressive disorders. Since anxiety and depression are common, and frequently have their onset early in life, a better understanding of the factors related to their childhood onset will facilitate the development of new more effective neurally informed interventions. A nonhuman primate (NHP) developmental model of childhood AT has been established, which has provided an understanding of the neural systems and molecular mechanisms mediating the development of AT...
May 11, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28499278/long-non-coding-rnas-in-b-cell-malignancies-a-comprehensive-overview
#9
REVIEW
Lucia Nobili, Domenica Ronchetti, Elisa Taiana, Antonino Neri
B-cell malignancies constitute a large part of hematological neoplasias. They represent a heterogeneous group of diseases, including Hodgkin's lymphoma, most non-Hodgkin's lymphomas (NHL), some leukemias and myelomas. B-cell malignancies reflect defined stages of normal B-cell differentiation and this represents the major basis for their classification. Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts longer than 200 nucleotides, for which many recent studies have demonstrated a function in regulating gene expression, cell biology and carcinogenesis...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498283/synovial-sarcoma-of-peripheral-nerves-analysis-of-15-cases
#10
John S A Chrisinger, Usama I Salem, Lars-Gunnar Kindblom, Behrang Amini, Magnus Hansson, Jeanne M Meis
Synovial sarcoma of peripheral nerve (SSPN) is rare with only 26 cases reported in English. SSPN is often mistaken for a benign or malignant peripheral nerve sheath tumor (PNST) by clinicians and pathologists. Fifteen cases of SSPN were retrieved from the pathology files of 3 institutions. All tumors arose in a nerve based on imaging and/or operative findings and the diagnoses were histologically confirmed. Neuropathic symptoms predominated in 11 women and 4 men, 19- to 62-year-old (median, 39 years) with tumors involving the ulnar (5), median (3), peroneal (3) or sciatic (2) nerve, or the L4 or T1 nerve root (2)...
May 11, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28498257/the-addition-of-adjuvant-chemotherapy-to-radiation-in-early-stage-high-risk-endometrial-cancer-survival-outcomes-and-patterns-of-care
#11
Dustin Boothe, Ned Williams, Bismarck Odei, Matthew M Poppe, Theresa L Werner, Gita Suneja, David K Gaffney
OBJECTIVE: Early-stage high-risk endometrial cancer (HREC) treated with adjuvant radiotherapy (aRT) alone has been associated with an increased risk of distant relapse. The addition of chemotherapy to radiotherapy (aCRT) may benefit overall survival (OS). We investigated the patterns-of-care and OS benefit of aCRT in HREC by analyzing a large national registry. METHODS: Our query was limited to patients with the International Federation of Gynecology and Obstetrics stage IB and II HREC with either papillary serous, clear cell, or grade 3 adenocarcinoma, diagnosed between 2004 and 2012...
June 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28493608/the-epidemiology-of-emergency-department-trauma-discharges-in-the-united-states
#12
Charles J DiMaggio, Jacob B Avraham, David C Lee, Spiros G Frangos, Stephen P Wall
OBJECTIVE: Injury related morbidity and mortality is an important emergency medicine and public health challenge in the United States (US). Here we describe the epidemiology of traumatic injury presenting to US emergency departments, define changes in types and causes of injury among the elderly and the young, characterize the role of trauma centers and teaching hospitals in providing emergency trauma care, and estimate the overall economic burden of treating such injuries. METHODS: We conducted a secondary retrospective, repeated cross-sectional study of the Nationwide Emergency Department Data Sample (NEDS), the largest all-payer emergency department survey database in the US...
May 11, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28483773/ingeborg-rapoport
#13
Ned Stafford
No abstract text is available yet for this article.
May 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28483192/no-association-between-influenza-vaccination-during-pregnancy-and-adverse-birth-outcomes
#14
Ousseny Zerbo, Sharareh Modaressi, Berwick Chan, Kristin Goddard, Ned Lewis, Karin Bok, Bruce Fireman, Nicola P Klein, Roger Baxter
BACKGROUND: Pregnant women are recommended to receive inactivated influenza vaccination anytime during pregnancy. Studies have investigated the impact of influenza vaccination during pregnancy on birth outcomes and results on preterm birth have been inconsistent. METHODS: We conducted a retrospective cohort study among children born at a gestational age≥24weeks from January 1, 2010 to December 31, 2015 at Kaiser Permanente Northern California facilities (KPNC)...
May 31, 2017: Vaccine
https://www.readbyqxmd.com/read/28473032/microbial-consortia-at-steady-supply
#15
Thibaud Taillefumier, Anna Posfai, Yigal Meir, Ned S Wingreen
Metagenomics has revealed hundreds of species in almost all microbiota. In a few well-studied cases, microbial communities have been observed to coordinate their metabolic fluxes. In principle, microbes can divide tasks to reap the benefits of specialization, as in human economies. However, the benefits and stability of an economy of microbial specialists are far from obvious. Here, we physically model the population dynamics of microbes that compete for steadily supplied resources. Importantly, we explicitly model the metabolic fluxes yielding cellular biomass production under the constraint of a limited enzyme budget...
May 5, 2017: ELife
https://www.readbyqxmd.com/read/28466376/phase-i-study-of-nedaplatin-a-platinum-based-antineoplastic-drug-combined-with-nab-paclitaxel-in-patients-with-advanced-squamous-non-small-cell-lung-cancer
#16
Satoshi Igawa, Sakiko Otani, Yoshiro Nakahara, Shinichiro Ryuge, Yasuhiro Hiyoshi, Tomoya Fukui, Hisashi Mitsufuji, Masaru Kubota, Masato Katagiri, Yuichi Sato, Jiichiro Sasaki, Noriyuki Masuda
Background This study was designed to determine the recommended dose of a combination of nedaplatin (NED) and nab-paclitaxel (nab-PTX) in chemotherapy-naive patients with advanced squamous non-small-cell lung cancer (NSCLC). Methods Patients received escalating doses of NED on day 1 and nab-PTX on days 1, 8, and 15 every 4 weeks by an intravenous infusion for up to six cycles. Results A dose of 100 mg/m(2) NED and 100 mg/m(2) nab-PTX was determined to be the recommended dose for patients with advanced squamous NSCLC...
May 2, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/28464432/septic-arthritis-in-the-emergency-departments-in-the-u-s-a-national-study-of-healthcare-utilization-and-time-trends
#17
Jasvinder A Singh, Shaohua Yu
OBJECTIVE: To assess health care utilization and emergency department (ED) charges for septic arthritis. METHODS: We performed a retrospective cohort study of ED visits with septic arthritis as the primary diagnosis using the U.S. Nationwide Emergency Department Sample (NEDS) data from 2009-12. We examined ED charges, hospitalization and associated time-trends. Multivariable models adjusted for demographics (age, sex, insurance status, residence, household income), comorbidity and hospital characteristics to assess factors associated with ED charges and hospitalization...
May 2, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28460442/egfr-mediates-activation-of-ret-in-lung-adenocarcinoma-with-neuroendocrine-differentiation-characterized-by-ascl1-expression
#18
Kaustubh Bhinge, Lin Yang, Simone Terra, Aqsa Nasir, Prasuna Muppa, Marie Christine Aubry, Joanne Yi, Nafiseh Janaki, Irina V Kovtun, Stephen J Murphy, Geoffrey Halling, Hamed Rahi, Aaron Mansfield, Mariza de Andrade, Ping Yang, George Vasmatzis, Tobias Peikert, Farhad Kosari
Achaete-scute homolog 1 (ASCL1) is a neuroendocrine transcription factor specifically expressed in 10-20% of lung adenocarcinomas (AD) with neuroendocrine (NE) differentiation (NED). ASCL1 functions as an upstream regulator of the RET oncogene in AD with high ASCL1 expression (A+AD). RET is a receptor tyrosine kinase with two main human isoforms; RET9 (short) and RET51 (long). We found that elevated expression of RET51 associated mRNA was highly predictive of poor survival in stage-1 A+AD (p=0.0057). Functional studies highlighted the role of RET in promoting invasive properties of A+AD cells...
April 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28458448/evaluating-the-improvement-in-shear-wave-speed-image-quality-using-multidimensional-directional-filters-in-the-presence-of-reflection-artifacts
#19
Samantha L Lipman, Ned C Rouze, Mark L Palmeri, Kathryn R Nightingale
Shear waves propagating through interfaces where there is a change in stiffness cause reflected waves that can lead to artifacts in shear wave speed (SWS) reconstructions. Two-dimensional (2-D) directional filters are commonly used to reduce in-plane reflected waves; however, SWS artifacts arise from both in- and out-of-imaging-plane reflected waves. Herein, we introduce 3-D shear wave reconstruction methods as an extension of the previous 2-D estimation methods and quantify the reduction in image artifacts through the use of volumetric SWS monitoring and 4-D-directional filters...
August 2016: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28456069/child-maltreatment-in-u-s-emergency-departments-imaging-and-admissions
#20
Krista K Wheeler, Junxin Shi, Henry Xiang, Kathy J Haley, Jonathan I Groner
OBJECTIVE: We report imaging and admission ratios for children with definitive and suggestive maltreatment in a national sample of emergency departments (EDs). METHODS: Using the 2012 Nationwide Emergency Department Sample (NEDS), we generated national estimates of ED visits for children <10 years with both definitive and suggestive maltreatment. Outcomes were admission/transfer ratios for children <10years and screening ratios by skeletal surveys and head computed tomography (CT) for children <2 years with suspected physical abuse...
April 28, 2017: Child Abuse & Neglect
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