Read by QxMD icon Read


Therese E Kenny, Megan Van Wijk, Christopher Singleton, Jacqueline C Carter
OBJECTIVE: Although studies on sleep difficulties in binge eating disorder (BED) have produced inconsistent findings, research has linked poor sleep to the presence of related concerns (e.g., obesity, anxiety, and depression). To clarify the relationship between BED and sleep problems, this study aimed to compare insomnia symptoms in individuals with BED and those with no history of an eating disorder (NED). METHOD: An adult community sample of individuals with BED (N = 68) and NED (N = 78) completed measures of insomnia, depression and anxiety, and eating disorder symptoms...
March 15, 2018: European Eating Disorders Review: the Journal of the Eating Disorders Association
Anna Hartmann Schmidt, Morten Høyer, Bent Frode Skov Jensen, Mads Agerbaek
BACKGROUND: Resection of residual masses after chemotherapy plays a crucial role in management of patients with germ cell tumours (GCTs). The extent of surgery is controversial and we present the experiences from Aarhus University Hospital over a 20-year period. The aim was to evaluate survival, complications, working ability and quality of life (QOL) following a limited surgical procedure performed to resect residual masses in non-seminomatous testicular cancer patients after chemotherapy...
March 14, 2018: Acta Oncologica
Ned Stafford
No abstract text is available yet for this article.
March 9, 2018: BMJ: British Medical Journal
Thaddeus S Block, Harvey Kushner, Ned Kalin, Craig Nelson, Joseph Belanoff, Alan Schatzberg
BACKGROUND: Patients with psychotic depression exhibit elevated cortisol levels. Competitively antagonizing cortisol at the glucocorticoid receptor with mifepristone demonstrated therapeutic benefit in early studies of patients with psychotic depression. We present a combined analysis of all controlled phase 2 and 3 studies to report antipsychotic differences between treatment with mifepristone or placebo and to evaluate the relative contributions to response of attaining an a priori-defined, high mifepristone plasma level and markers of glucocorticoid receptor antagonism (increases in adrenocorticotropin hormone and cortisol) with treatment...
January 31, 2018: Biological Psychiatry
Irene Malkwitz, Angela Berndt, Arwid Daugschies, Berit Bangoura
Toxoplasma gondii is known to be able to infect any nucleated cell including immune cells like macrophages. In addition, it is assumed that macrophages serve as trojan horse during distribution in hosts. The underlying causes of parasite host interaction remain yet not fully understood. The aim of the present study was to investigate susceptibility of chicken macrophages to infection with T. gondii and the process of infection in avian cells in comparison to cells of mammalian origin. Primary avian blood monocyte-derived macrophages were infected with tachyzoites of type II (ME49) and III (NED) strains...
March 5, 2018: Experimental Parasitology
Young Hong, Jonathan Rice, Divyansh Sharma, Robert C G Martin
INTRODUCTION: Pancreatic ductal adenocarcinoma (PDAC) often presents late with only 20% of patients being candidates for resection while majority already have advanced metastases with median overall survival of 3-6 months. Currently, the role of oligometastasectomy and local therapy options in PDAC is unknown in patients who have favorable response to systemic chemotherapy. The aim of this study is to analyze the survival outcome of oligometastasectomy and local IRE therapy in select patients who are treated with systemic chemotherapy for PDAC metastases...
March 2, 2018: American Journal of Surgery
Stina Holmgren Rondahl, Fabien Pointurier, Linnea Ahlinder, Henrik Ramebäck, Olivier Marie, Brice Ravat, François Delaunay, Emma Young, Ned Blagojevic, James R Hester, Gordon Thorogood, Aubrey N Nelwamondo, Tshepo P Ntsoane, Sarah K Roberts, Kiel S Holliday
This work presents the results for identification of chemical phases obtained by several laboratories as a part of an international nuclear forensic round-robin exercise. In this work powder X-ray diffraction (p-XRD) is regarded as the reference technique. Neutron diffraction produced a superior high-angle diffraction pattern relative to p-XRD. Requiring only small amounts of sample, µ-Raman spectroscopy was used for the first time in this context as a potentially complementary technique to p-XRD. The chemical phases were identified as pure UO2 in two materials, and as a mixture of UO2 , U3 O8 and an intermediate species U3 O7 in the third material...
2018: Journal of Radioanalytical and Nuclear Chemistry
Farina Mujeeb, Ahamad Faiz Khan, Preeti Bajpai, Neelam Pathak
Background: The antioxidant potential of medicinal plants has been illustrated through many reports clearly depicting that plants are a rich source of antioxidants, making them a great resource of novel drugs and health-care products. Objectives: The current study is, therefore, focused toward the assessment of antioxidant properties along with the presence of phytochemicals in leaves of 18 varieties/accessions of Aegle marmelos . Materials and Methods: The antioxidant activities were initially measured using superoxide radical scavenging method, 2, 2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing ability of plasma assays...
January 2018: Pharmacognosy Magazine
Ned H Kalin
No abstract text is available yet for this article.
March 1, 2018: American Journal of Psychiatry
Muayyad M Ahmad, Ruba Musallam, Abla Habeeb Allah, Laila Al-Daken, Hana Abu-Snieneh, Ghadeer Al-Dweik
Objective: This study aimed to evaluate the maturity level of stigma as a concept in nursing and its relationship to care provided for patients with cancer. Methods: The four principles of Morse and his colleagues were used to evaluate the maturity level of the stigma concept: epistemological, logical, pragmaticl, and linguistic. Analysis was conducted with the literature published between 2006 and 2016. Results: The findings of this study suggest that the concept of stigma in nursing is immature, defined inconsistently, and measured with different instruments...
February 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Zachary J Grabel, Sheyan J Armaghani, Catphuong Vu, Amit Jain, S Tim Yoon
BACKGROUND: The optimal form of treatment for C2 spine fractures is controversial. This investigation analyzed the variations in treatment of C2 fractures over time, by age group, and by geographic location. METHODS: The Nationwide Emergency Department Sample (NEDS) database was queried to identify patients 18 years and older who sustained C2 fracture without neurological injury from 2006-2012. Subsequently patients were further filtered based on the intervention they received: collar, halo, and surgery...
February 21, 2018: World Neurosurgery
Ned Van Eps, Christian Altenbach, Lydia N Caro, Naomi R Latorraca, Scott A Hollingsworth, Ron O Dror, Oliver P Ernst, Wayne L Hubbell
More than two decades ago, the activation mechanism for the membrane-bound photoreceptor and prototypical G protein-coupled receptor (GPCR) rhodopsin was uncovered. Upon light-induced changes in ligand-receptor interaction, movement of specific transmembrane helices within the receptor opens a crevice at the cytoplasmic surface, allowing for coupling of heterotrimeric guanine nucleotide-binding proteins (G proteins). The general features of this activation mechanism are conserved across the GPCR superfamily...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
Ned Amendola
No abstract text is available yet for this article.
February 21, 2018: Journal of Bone and Joint Surgery. American Volume
Rayan El Sibai, Rana Bachir, Mazen El Sayed
INTRODUCTION: Drowning leads to 372,000 deaths annually worldwide and to severe morbidity secondary to asphyxiation or aspiration. Previous studies described submersion injuries mainly in the pediatric population. This study describes characteristics of patients presenting with submersion injuries to United States emergency departments (EDs) and identifies predictors of poor outcomes (death or long term neurologic deficits) after drowning. METHODS: This retrospective cross-sectional study included ED visits for submersion injuries from the United States 2013 Nationwide Emergency Department Sample (NEDS) dataset using discharge data (CCS diagnosis codes)...
February 13, 2018: Injury
Nicole M Armstrong, Pamela J Surkan, Glenn J Treisman, Ned C Sacktor, Michael R Irwin, Linda A Teplin, Ron C Stall, Lisa P Jacobson, Alison G Abraham
OBJECTIVES: Center of Epidemiologic Studies-Depression Scale (CES-D) provides a snapshot of symptom severity at a single point in time. However, the best way of using CES-D to classify long-term depression is unclear. METHOD: To identify long-term depression among HIV-infected and HIV-uninfected 50+ year-old men who have sex with men (MSM) with at least 5 years of follow-up, we compared sensitivities and specificities of CES-D-based metrics (baseline CES-D; four consecutive CES-Ds; group-based trajectory models) thresholded at 16 and 20 to a clinician's evaluation of depression phenotype based on all available data including CES-D history, depression treatment history, drug use history, HIV disease factors, and demographic characteristics...
February 9, 2018: Aging & Mental Health
Samantha L Lipman, Ned C Rouze, Mark L Palmeri, Kathryn R Nightingale
Shear wave elasticity imaging (SWEI) characterizes the mechanical properties of human tissues to differentiate healthy from diseased tissue. Commercial scanners tend to reconstruct shear wave speeds for a region of interest using time-of-flight methods reporting a single shear wave speed (or elastic modulus) to the end user under the assumptions that tissue is elastic and shear wave speeds are not dependent on the frequency content of the shear waves. Human tissues, however, are known to be viscoelastic, resulting in dispersion and attenuation...
February 5, 2018: Ultrasound in Medicine & Biology
Yi-Da Tang, Wenyao Wang, Min Yang, Kuo Zhang, Jing Chen, Shubin Qiao, Hongbing Yan, Yongjian Wu, Xiaohong Huang, Bo Xu, Runlin Gao, Yuejin Yang
Background -Patients undergoing percutaneous coronary intervention (PCI) react differently to antiplatelet drugs. Those with low responsiveness to clopidogrel have a higher risk of cardiac ischemic events. The goal of this study is to conduct a head-to-head comparison of the safety and effectiveness of intensified antiplatelet therapies (either double-dose clopidogrel [DOUBLE] or adjunctive cilostazol [TRIPLE]) and conventional strategy (STANDARD) in post-PCI patients. Methods -In this single-center, randomized, controlled trial, we used thromboelastography (TEG), a platelet function test, to select 1078 PCI patients at high thrombotic risk and compared the intensified antiplatelet therapies with standard antiplatelet therapy...
February 2, 2018: Circulation
S Ballou, W Hirsch, P Singh, V Rangan, J Nee, J Iturrino, T Sommers, J Zubiago, N Sengupta, A Bollom, M Jones, A C Moss, S N Flier, A S Cheifetz, A Lembo
BACKGROUND: Despite advances in treatment, patients with inflammatory bowel disease (IBD) frequently require emergency department (ED) visits and hospitalisations. AIMS: To analyse trends in ED visits and subsequent hospitalisations for IBD in the United States (US). METHODS: Data were analysed from the Nationwide Emergency Department Sample (NEDS) years 2006-2014. The NEDS is the largest all-payer ED database in the US, weighted to represent 135 million visits/year...
February 7, 2018: Alimentary Pharmacology & Therapeutics
Edward Faught, Jerzy P Szaflarski, Joshua Richman, Ellen Funkhouser, Roy C Martin, Kendra Piper, Chen Dai, Lucia Juarez, Maria Pisu
OBJECTIVE: To determine the frequency of older Americans with epilepsy receiving concomitant prescriptions for antiepileptic drugs (AEDs) and non-epilepsy drugs (NEDs) which could result in significant pharmacokinetic (PK) interaction, and to assess the contributions of racial/ethnic, socioeconomic, and demographic factors. METHODS: Retrospective analyses of 2008-2010 Medicare claims for a 5% random sample of beneficiaries ≥67 years old in 2009 augmented for minority representation...
February 7, 2018: Epilepsia
Yuh-Jiin Ivy Jong, Steven K Harmon, Karen L O'Malley
The trillions of synaptic connections within the human brain are shaped by experience and neuronal activity both of which underlie synaptic plasticity and ultimately learning and memory. G protein-coupled receptors (GPCRs) play key roles in synaptic plasticity by strengthening or weakening synapses and/or shaping dendritic spines. While most studies of synaptic plasticity have focused on cell surface receptors and their downstream signaling partners, emerging data point to a critical new role for the very same receptors to signal from inside the cell...
February 6, 2018: ACS Chemical Neuroscience
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"