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https://www.readbyqxmd.com/read/28328547/predictors-and-impact-of-self-reported-suboptimal-effort-on-estimates-of-prevalence-of-hiv-associated-neurocognitive-disorders
#1
Andrew J Levine, Eileen Martin, Ned Sacktor, Cynthia Munro, James Becker
BACKGROUND: Prevalence estimates of HIV-associated neurocognitive disorders (HAND) may be inflated. Estimates are determined via cohort studies in which participants may apply suboptimal effort on neurocognitive testing, thereby inflating estimates. Additionally, fluctuating HAND severity over time may be related to inconsistent effort. To address these hypotheses, we characterized effort in the Multicenter AIDS Cohort Study. METHODS: After neurocognitive testing, 935 participants (525 HIV-, 410 HIV+) completed the Visual Analogue Effort Scale (VAES), rating their effort from 0-100%...
March 22, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28301185/embodied-memory-allows-accurate-and-stable-perception-of-hidden-objects-despite-orientation-change
#2
Jing Samantha Pan, Ned Bingham, Geoffrey P Bingham
Rotating a scene in a frontoparallel plane (rolling) yields a change in orientation of constituent images. When using only information provided by static images to perceive a scene after orientation change, identification performance typically decreases (Rock & Heimer, 1957). However, rolling generates optic flow information that relates the discrete, static images (before and after the change) and forms an embodied memory that aids recognition. The embodied memory hypothesis predicts that upon detecting a continuous spatial transformation of image structure, or in other words, seeing the continuous rolling process and objects undergoing rolling observers should accurately perceive objects during and after motion...
March 16, 2017: Journal of Experimental Psychology. Human Perception and Performance
https://www.readbyqxmd.com/read/28283597/overlapping-features-of-polymyositis-and-inclusion-body-myositis-in-hiv-infected-patients
#3
Thomas E Lloyd, Iago Pinal-Fernandez, E Harlan Michelle, Lisa Christopher-Stine, Katherine Pak, Ned Sacktor, Andrew L Mammen
OBJECTIVE: To characterize patients with myositis with HIV infection. METHODS: All HIV-positive patients with myositis seen at the Johns Hopkins Myositis Center from 2003 to 2013 were included in this case series. Muscle biopsy features, weakness pattern, serum creatine kinase (CK) level, and anti-nucleotidase 1A (NT5C1A) status of HIV-positive patients with myositis were assessed. RESULTS: Eleven of 1,562 (0.7%) patients with myositis were HIV-positive...
March 10, 2017: Neurology
https://www.readbyqxmd.com/read/28283186/imaging-genetics-and-genomics-in-psychiatry-a-critical-review-of-progress-and-potential
#4
REVIEW
Ryan Bogdan, Betty Jo Salmeron, Caitlin E Carey, Arpana Agrawal, Vince D Calhoun, Hugh Garavan, Ahmad R Hariri, Andreas Heinz, Matthew N Hill, Andrew Holmes, Ned H Kalin, David Goldman
Imaging genetics and genomics research has begun to provide insight into the molecular and genetic architecture of neural phenotypes and the neural mechanisms through which genetic risk for psychopathology may emerge. As it approaches its third decade, imaging genetics is confronted by many challenges, including the proliferation of studies using small sample sizes and diverse designs, limited replication, problems with harmonization of neural phenotypes for meta-analysis, unclear mechanisms, and evidence that effect sizes may be more modest than originally posited, with increasing evidence of polygenicity...
January 13, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28273370/features-of-papillary-thyroid-microcarcinoma-associated-with-lateral-cervical-lymph-node-metastasis
#5
Min Ji Jeon, Mi Sun Chung, Hyemi Kwon, Mijin Kim, Suyeon Park, Jung Hwan Baek, Dong Eun Song, Tae-Yon Sung, Suck Joon Hong, Tae Yong Kim, Won Bae Kim, Young Kee Shong, Jeong Hyun Lee, Won Gu Kim
OBJECTIVES: Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the preoperative features of PTMC associated with LCLN metastasis. DESIGN AND PATIENTS: This retrospective cohort study with a nested, matched case-control design included 199 PTMC patients with LCLN metastasis at initial surgery (N1b group) and 196 PTMC patients without any LN metastasis or persistent disease (N0 NED group) as controls; primary tumour sizes were matched...
March 8, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28258022/probes-for-protein-adduction-in-cholesterol-biosynthesis-disorders-alkynyl-lanosterol-as-a-viable-sterol-precursor
#6
Keri A Tallman, Hye-Young H Kim, Zeljka Korade, Thiago C Genaro-Mattos, Phillip A Wages, Wei Liu, Ned A Porter
The formation of lipid electrophile-protein adducts is associated with many disorders that involve perturbations of cellular redox status. The identities of adducted proteins and the effects of adduction on protein function are mostly unknown and an increased understanding of these factors may help to define the pathogenesis of various human disorders involving oxidative stress. 7-Dehydrocholesterol (7-DHC), the immediate biosynthetic precursor to cholesterol, is highly oxidizable and gives electrophilic oxysterols that adduct proteins readily, a sequence of events proposed to occur in Smith-Lemli-Opitz syndrome (SLOS), a human disorder resulting from an error in cholesterol biosynthesis...
February 24, 2017: Redox Biology
https://www.readbyqxmd.com/read/28246089/herman-vanden-berghe
#7
Ned Stafford
No abstract text is available yet for this article.
February 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28244767/registro-del-grupo-nadya-senpe-de-nutrici%C3%A3-n-enteral-domiciliaria-en-espa%C3%A3-a-a%C3%A3-os-2014-y-2015
#8
Carmina Wanden-Berghe, Luis Miguel Luengo, Julia Álvarez, Rosa Burgos, Cristina Cuerda, Pilar Matía, Carmen Gómez Candela, Miguel Ángel Martínez Olmos, Montserrat Gonzalo, Alicia Calleja, Cristina Campos, Antonio Pérez de la Cruz, José Antonio Irles, Pere Leyes, Rebeca Sánchez, Daniel De Luis Román, Daniel Cardona, Nieves Santacruz, José Pablo Suárez, Carmen Ballesta, Jordi Salas, María Ángeles Penacho, Carmen Gardez, María José Martínez, Bárbara Cánovas, José Manuel Moreno, Dolores Del Olmo, Fátima Carabaña, Nuria Virgili, Isabel Higuera, Silvia Mauri, Olga Sánchez-Vilar, Nuria Miserachs, Miguel Ángel Ponce, Yaiza García, Jesús M Morán, Antxón Apezetxea, Cristina Tejera, Alfonso Calañas, Ana Cantón, Patricia Díaz, Grupo Nadya-Senpe
Objetivo: exponer los resultados del registro de nutrición enteral domiciliaria (NED) del año 2014 y 2015 del Grupo NADYA-SENPE.Métodos: se recopilaron los pacientes introducidos en el registro desde el 1 de enero al 31 de diciembre de 2014 y la mismas fechas de 2015, y se procedió al análisis descriptivo y analítico de los datos.Resultados: en el año 2014, se registraron 3.749 pacientes y en 2015, 4.202; la prevalencia fue de 80,58 pacientes/millón de habitantes en el año 2014 y de 90,51 en 2015. Por sexos, hubo un 49,9% de mujeres en 2014 y un 50,3% en 2015...
February 1, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/28224298/the-performance-of-the-msept9-assay-is-influenced-by-algorithm-cancer-stage-and-age-but-not-sex-and-cancer-location
#9
Lele Song, Jia Jia, Haotian Yu, Xiumei Peng, Wenhua Xiao, Yuan Gong, Guangpeng Zhou, Xiaoliang Han, Yuemin Li
PURPOSE: This study aims to examine the influence of algorithm and subject-related factors, including cancer stage, age, sex, and cancer location, on the performance of the SEPT9 gene methylation test, an assay approved by the US FDA for colorectal cancer (CRC) screening. METHODS: A total of 1225 subjects were recruited in this opportunistic screening study, including 388 CRC patients, 139 subjects with adenoma, 108 subjects with hyperplastic polyps, and 590 subjects with no evidence of disease (NED)...
February 21, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28220990/oxidative-stress-serotonergic-changes-and-decreased-ultrasonic-vocalizations-in-a-mouse-model-of-smith-lemli-opitz-syndrome
#10
N F Sharif, Z Korade, N A Porter, F E Harrison
Smith-Lemli-Opitz syndrome is an inherited monogenic disorder in which mutations to the 7-dehydrocholesterol (7-DHC) reductase (Dhcr7) gene lead to deficits in cholesterol synthesis. As a result, many patients suffer from gross physiological and neurological deficits. The purpose of this study was to identify a potential abnormal behavioral phenotype in a compound mutant mouse model for Smith-Lemli-Opitz disease (Dhcr7 (Δ3)(-5/)(T93M) ) to further validate the model and to provide potential targets for future therapeutic interventions...
February 21, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28219885/hans-rosling
#11
Ned Stafford
No abstract text is available yet for this article.
February 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28202546/identification-of-a-novel-series-of-anti-inflammatory-and-anti-oxidative-phospholipid-oxidation-products-containing-cyclopentenone-moiety-in-vitro-and-in-vivo-implication-in-atherosclerosis
#12
Jianhong Lu, Shuyuan Guo, Xinli Xue, Qun Chen, Jing Ge, Yujuan Zhuo, Huiqin Zhong, Buxing Chen, Mingming Zhao, Wei Han, Takashi Suzuki, Mingjiang Zhu, Lin Xia, Claus Schneider, Timothy S Blackwell, Ned A Porter, Lemin Zheng, Sotirios Tsimikas, Huiyong Yin
Oxidative stress and inflammation are two major contributing factors to atherosclerosis, a leading cause for cardiovascular diseases (CVDs). Oxidation of phospholipids on the surface of low density lipoprotein (LDL) particles generated under oxidative stress has been associated with the progression of atherosclerosis but the underlying molecular mechanisms remain poorly defined. We identified a novel series of oxidation products containing cyclopentenone moiety, termed deoxy-A2/J2-isoprostanes-phosphocholine (deoxy-A2/J2-IsoP-PC), from 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (PAPC) in vivo using mass spectrometry and by comparison to a chemically synthesized standard...
February 15, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28202290/effect-of-psychotropic-drug-treatment-on-sterol-metabolism
#13
Željka Korade, Wei Liu, Emily B Warren, Kristan Armstrong, Ned A Porter, Christine Konradi
Cholesterol metabolism is vital for brain function. Previous work in cultured cells has shown that a number of psychotropic drugs inhibit the activity of 7-dehydrocholesterol reductase (DHCR7), an enzyme that catalyzes the final steps in cholesterol biosynthesis. This leads to the accumulation of 7-dehydrocholesterol (7DHC), a molecule that gives rise to oxysterols, vitamin D, and atypical neurosteroids. We examined levels of cholesterol and the cholesterol precursors desmosterol, lanosterol, 7DHC and its isomer 8-dehydrocholesterol (8DHC), in blood samples of 123 psychiatric patients on various antipsychotic and antidepressant drugs, and 85 healthy controls, to see if the observations in cell lines hold true for patients as well...
February 12, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28179227/germany-sets-up-new-agency-to-oversee-production-of-medicinal-cannabis
#14
Ned Stafford
No abstract text is available yet for this article.
February 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28174151/elizaveta-glinka
#15
Ned Stafford
No abstract text is available yet for this article.
February 7, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28174017/propagation-rate-constants-for-the-peroxidation-of-sterols-on-the-biosynthetic-pathway-to-cholesterol
#16
Connor R Lamberson, Hubert Muchalski, Kari B McDuffee, Keri A Tallman, Libin Xu, Ned A Porter
The free radical chain autoxidation of cholesterol and the oxidation products formed, i.e. oxysterols, have been the focus of intensive study for decades. The peroxidation of sterol precursors to cholesterol such as 7-dehydrocholesterol (7-DHC) and desmosterol as well as their oxysterols has received less attention. The peroxidation of these sterol precursors can become important under circumstances in which genetic conditions or exposures to small molecules leads to an increase of these biosynthetic intermediates in tissues and fluids...
February 5, 2017: Chemistry and Physics of Lipids
https://www.readbyqxmd.com/read/28156453/frequency-predictors-and-outcomes-of-urine-drug-test-among-patients-with-advanced-cancer-on-chronic-opioid-therapy-at-an-outpatient-supportive-care-clinic
#17
Tonya Edwards, David Hui, Jessica Marie Waletich-Flemming, Suresh K Reddy, Diane D Liu, Jimin Wu, Eduardo Bruera
94 Background: Data on the utilization and outcomes of urine drug tests (UDT) among advanced cancer patients is limited. The main objective of this study was to determine the factors associated with UDT ordering and results in advanced cancer outpatients. METHODS: A retrospective chart review of 1058 patients seen from March 2014 to November 2015 at an outpatient supportive care clinic was conducted. Sixty-one patients on chronic opioid therapy who underwent UDT were identified. A control group of 120 patients who did not undergo UDT was selected for comparison of information on demographic and clinical characteristics...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28128613/metabolic-trade-offs-promote-diversity-in-a-model-ecosystem
#18
Anna Posfai, Thibaud Taillefumier, Ned S Wingreen
In nature, a large number of species can coexist on a small number of shared resources; however, resource-competition models predict that the number of species in steady coexistence cannot exceed the number of resources. Motivated by recent studies of phytoplankton, we introduce trade-offs into a resource-competition model and find that an unlimited number of species can coexist. Our model spontaneously reproduces several notable features of natural ecosystems, including keystone species and population dynamics and abundances characteristic of neutral theory, despite an underlying non-neutral competition for resources...
January 13, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28122802/hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-a-family-affair
#19
Jiasian Teh, Ned Kinnear, Hannah Douglass-Molloy, Derek Barrry Hennessey
A 49-year-old woman with cutaneous and uterine leiomyomas, flank pain and a family history of hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome sought genetic testing. She was found to harbour a fumarate hydratase (FH) genetic mutation and a previously undetected renal tumour. The patient underwent radical nephrectomy, and remains well at follow-up. HLRCC syndrome is a rare autosomal dominant disease, with patients at increased risk for cutaneous leiomyomas, early-onset uterine leiomyomas and aggressive renal carcinoma...
January 25, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28119306/john-balint
#20
Ned Stafford
No abstract text is available yet for this article.
January 24, 2017: BMJ: British Medical Journal
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