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https://www.readbyqxmd.com/read/27899941/influence-of-increased-epicardial-adipose-tissue-volume-on-1-year-in-stent-restenosis-in-patients-who-received-coronary-stent-implantation
#1
Ying Zhou, Hua-Wei Zhang, Feng Tian, Jin-Song Chen, Tian-Wen Han, Ya-Hang Tan, Jia Zhou, Tao Zhang, Jing Jing, Yun-Dai Chen
BACKGROUND: Epicardial adipose tissue (EAT) is significantly associated with the formation and composition of coronary atherosclerotic plaque, cardiac events and the clinical prognosis of coronary heart disease. But, whether increased EAT deposition may affect the incidence of in-stent restenosis (ISR) is currently unclear. This study used coronary computed tomography angiography (CCTA) as a mean to investigate whether increased EAT volume was associated with ISR. METHODS: A total of 364 patients who underwent 64-slice CCTA examination for the evaluation of suspected coronary artery disease, and subsequently underwent percutaneous coronary intervention (PCI) for the first time, and then accepted coronary angiography (CA) follow-up for ISR examination in one year, were retrospectively included in this study...
September 2016: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/27889886/association-of-midlife-smoking-status-with-change-in-processing-speed-and-mental-flexibility-among-hiv-seropositive-and-hiv-seronegative-older-men-the-multicenter-aids-cohort-study
#2
Wajiha Z Akhtar-Khaleel, Robert L Cook, Steve Shoptaw, Eric N Miller, Ned Sacktor, Pamela J Surkan, Jim Becker, Linda A Teplin, Rebecca J Beyth, Catherine Price, Michael Plankey
Smoking is a potential risk factor for age-related cognitive decline. To date, no study has examined the association between smoking and cognitive decline in men living with human immunodeficiency virus (HIV). The aim of this present study is to examine whether smoking status and severity in midlife is associated with a rate of decline in cognitive processing speed among older HIV-seropositive and HIV-seronegative men who have sex with men. Data from 591 older HIV-seropositive and HIV-seronegative men who have sex with men from the Multicenter AIDS Cohort Study were examined...
November 26, 2016: Journal of Neurovirology
https://www.readbyqxmd.com/read/27879254/henry-j-m-barnett
#3
Ned Stafford
No abstract text is available yet for this article.
November 22, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27873745/life-threatening-wunderlich-s-syndrome-with-concurrent-clopidogrel-use
#4
Ned Kinnear, Derek Barrry Hennessey, Hannah Douglass-Molloy, Greg Jack
Spontaneous non-traumatic renal haemorrhage, or Wunderlich's syndrome, is a rare but potentially life-threatening event. We present the case of a 63-year-old man on clopidogrel who became haemodynamically unstable as a result of this condition. Angioembolisation revealed the unusual finding of active bleeding from multiple distinct subsegmental renal vessels, for which haemostasis was successfully achieved by coil placement. The patient remains well and with near-normal renal function on follow-up.
November 9, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27856135/a-fresh-look-at-aging-proteins
#5
Reiner A Veitia
Recent analyses of the degradation profiles of thousands of proteins by McShane et al. have shown that many proteins are less stable during the hours following their synthesis. Many of such nonexponentially degraded (NED) proteins are components of macromolecular complexes. This may explain why, in cases of trisomy, the effect of overexpression can be attenuated.
November 14, 2016: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/27852333/emergency-department-visits-for-attempted-suicide-and-self-harm-in-the-usa-2006-2013
#6
J K Canner, K Giuliano, S Selvarajah, E R Hammond, E B Schneider
AIMS: To characterise and identify nationwide trends in suicide-related emergency department (ED) visits in the USA from 2006 to 2013. METHODS: We used data from the Nationwide Emergency Department Sample (NEDS) from 2006 to 2013. E-codes were used to identify ED visits related to suicide attempts and self-inflicted injury. Visits were characterised by factors such as age, sex, US census region, calendar month, as well as injury severity and mechanism. Injury severity and mechanism were compared between age groups and sex by chi-square tests and Wilcoxon rank-sum tests...
November 17, 2016: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/27844413/relationship-between-circulating-anti-thyroglobulin-antibodies-tgab-and-tumor-metabolism-in-patients-with-differentiated-thyroid-cancer-dtc-prognostic-implications
#7
S Morbelli, G Ferrarazzo, E Pomposelli, F Pupo, G Pesce, I Calamia, F Fiz, A Clapasson, M Bauckneht, M Minuto, G Sambuceti, M Giusti, M Bagnasco
PURPOSE: TgAb have been proposed as tumor markers in DTC. Recent evidence links TgAb levels with DTC aggressiveness. We aimed to evaluate the relationship between TgAb and tumor glucose metabolism in DTC patients. METHODS: Seventy-one DTC patients who underwent (18)F-FDG PET/CT were included. According to TgAb value and trends, patients were divided into TgAb positive (TgAb+) or negative (TgAb-) as well as in patients with increasing (Inc-TgAb) or decreasing (Dec-TgAb) trend...
November 14, 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27831982/comparative-effectiveness-of-treatments-for-chronic-low-back-pain-a-multiple-treatment-comparison-analysis
#8
Jeffrey A Rihn, Kristen Radcliff, Daniel C Norvell, Robert Eastlack, Frank M Phillips, Daniel Berland, Ned Sherry, Mitchell Freedman, Alexander R Vaccaro
STUDY DESIGN: A systematic review and network meta-analysis. OBJECTIVE: To determine current treatment options of chronic low back pain (LBP) as defined by randomized controlled trials (RCTs) and to compare effectiveness of those treatments using a mixed-treatment comparison (MTC). SUMMARY OF BACKGROUND DATA: It is important to provide an evidence-based assessment of the treatment options that exist for LBP. METHODS: A systematic search of RCTs was conducted in MEDLINE and the Cochrane Collaboration Library from 1990 to 2014...
November 9, 2016: Clinical Spine Surgery
https://www.readbyqxmd.com/read/27828747/book-reviews-handbook-of-critical-and-intensive-care-medicine-3rd-edn-joseph-varon-springer-2016-price-%C3%A2-42-99-pp-470-isbn-978-3-319-31603-1-introducing-palliative-care-5th-edn-edited-by-robert-twycross-andrew-wilcock-palliativedrugs-com-2016-price-%C3%A2-25-00
#9
https://www.readbyqxmd.com/read/27807850/temporal-behavior-of-seizures-and-interictal-bursts-in-prolonged-intracranial-recordings-from-epileptic-canines
#10
Hoameng Ung, Kathryn A Davis, Drausin Wulsin, Joost Wagenaar, Emily Fox, John J McDonnell, Ned Patterson, Charles H Vite, Gregory Worrell, Brian Litt
OBJECTIVE: Epilepsy is a chronic disorder, but seizure recordings are usually obtained in the acute setting. The chronic behavior of seizures and the interictal bursts that sometimes initiate them is unknown. We investigate the variability of these electrographic patterns over an extended period of time using chronic intracranial recordings in canine epilepsy. METHODS: Continuous, yearlong intracranial electroencephalography (iEEG) recordings from four dogs with naturally occurring epilepsy were analyzed for seizures and interictal bursts...
November 3, 2016: Epilepsia
https://www.readbyqxmd.com/read/27800282/digital-suicide-prevention-can-technology-become-a-game-changer
#11
REVIEW
Arshya Vahabzadeh, Ned Sahin, Amir Kalali
Suicide continues to be a leading cause of death and has been recognized as a significant public health issue. Rapid advances in data science can provide us with useful tools for suicide prevention, and help to dynamically assess suicide risk in quantitative data-driven ways. In this article, the authors highlight the most current international research in digital suicide prevention, including the use of machine learning, smartphone applications, and wearable sensor driven systems. The authors also discuss future opportunities for digital suicide prevention, and propose a novel Sensor-driven Mental State Assessment System...
May 2016: Innovations in Clinical Neuroscience
https://www.readbyqxmd.com/read/27789723/prevalence-and-correlates-of-persistent-hiv-1-rna-in-cerebrospinal-fluid-during-antiretroviral-therapy
#12
Albert M Anderson, Jose A Muñoz-Moreno, Daniel McClernon, Ronald J Ellis, Debra Cookson, David B Clifford, Ann C Collier, Benjamin B Gelman, Christina M Marra, Justin C McArthur, J Allen McCutchan, Susan Morgello, Ned Sacktor, David M Simpson, Donald R Franklin, Robert K Heaton, Igor Grant, Scott L Letendre
BACKGROUND:  Neurocognitive disorders remain common among HIV+ adults, perhaps due to persistent HIV-1 RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART). METHODS:  Using a single copy assay, we measured HIV-1 RNA in CSF and plasma from 220 HIV+ adults who were taking suppressive ART. Fifty-five participants were tested twice. RESULTS:  HIV-1 RNA was detected in 42.3% of CSF and 65.2% of plasma samples. Correlates of higher CSF HIV-1 RNA included higher nadir and current CD4+ counts, plasma HIV-1 RNA≥1 c/mL, and lower CPE values (Model p<0...
October 26, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27788528/factors-associated-with-knee-stiffness-following-surgical-management-of-multiligament-knee-injuries
#13
Jessica Hanley, Robert Westermann, Shane Cook, Natalie Glass, Ned Amendola, Brian R Wolf, Matthew Bollier
Postoperative knee stiffness can influence outcomes following operative treatment of multiligament knee injuries (MLKIs). The purpose of this study was to evaluate patient and surgical factors that may potentially contribute to stiffness following surgery for MLKIs. All surgically managed MLKIs involving two or more ligaments over a 10-year period at a single level one trauma center were included in this study. A retrospective review was performed to gather objective data related to the development of knee stiffness after surgery...
October 27, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27782039/performance-of-two-bioelectrical-impedance-analyses-in-the-diagnosis-of-overweight-and-obesity-in-children-and-adolescents-the-fuprecol-study
#14
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Javier Martínez-Torres, Katherine González-Ruíz, Emilio González-Jiménez, Jacqueline Schmidt-RioValle, Antonio Garcia-Hermoso
This study aimed to determine thresholds for percentage of body fat (BF%) corresponding to the cut-off values for overweight/obesity as recommended by the International Obesity Task Force (IOTF), using two bioelectrical impedance analyzers (BIA), and described the likelihood of increased cardiometabolic risk in our cohort defined by the IOTF and BF% status. Participants included 1165 children and adolescents (54.9% girls) from Bogotá (Colombia). Body mass index (BMI) was calculated from height and weight...
October 4, 2016: Nutrients
https://www.readbyqxmd.com/read/27781109/highlights-of-the-global-hiv-1-csf-escape-consortium-meeting-9-june-2016-bethesda-md-usa
#15
EDITORIAL
Jeymohan Joseph, Paola Cinque, Deborah Colosi, Ameet Dravid, Luminita Ene, Howard Fox, Dana Gabuzda, Magnus Gisslen, Sarah Beth Joseph, Scott Letendre, Shibani S Mukerji, Avindra Nath, Ignacio Perez-Valero, Deborah Persaud, Richard W Price, Vasudev R Rao, Ned Sacktor, Ronald Swanstrom, Alan Winston, Valerie Wojna, Edwina Wright, Serena Spudich
CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes...
October 5, 2016: Journal of Virus Eradication
https://www.readbyqxmd.com/read/27780287/infection-following-anterior-cruciate-ligament-reconstruction-an-analysis-of-6-389-cases
#16
Robert Westermann, Chris A Anthony, Kyle R Duchman, Yubo Gao, Andrew J Pugely, Carolyn M Hettrich, Ned Amendola, Brian R Wolf
Infection following anterior cruciate ligament reconstruction (ACLR) is rare. Previous authors have concluded that diabetes, tobacco use, and previous knee surgery may influence infection rates following ACLR. The purpose of this study was to identify a cohort of patients undergoing ACLR and define (1) the incidence of infection after ACLR from a large multicenter database and (2) the risk factors for infection after ACLR. We identified patients undergoing elective ACLRs in the American College of Surgeons National Surgical Quality Improvement Program database between 2007 and 2013...
October 25, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27777750/in-conversation-with%C3%A2-thomas-frederic-hornbein
#17
Ned Gilbert-Kawai
Whilst attending a conference in the not too distant past, I was fortunate enough to be seated at lunch next to a very eminent octogenarian academic. Conversation ensued, and I was instantly captivated by his stories. These were not narratives filled with scientific facts, but rather anecdotes of his life and the pathways he had taken to get where he was today. Fascinated by such accounts, I set about the task of interviewing persons of scientific acclaim, to learn more about their life stories and unwritten tales...
2016: Extreme Physiology & Medicine
https://www.readbyqxmd.com/read/27775942/pet-ct-with-68ga-dota-tate-for-diagnosis-of-neuroendocrine-differentiation-in-patients-with-castrate-resistant-prostate-cancer
#18
Ofer Nathan Gofrit, Stephen Frank, Amichay Meirovitz, Hovav Nechushtan, Marina Orevi
AIM: Castrate-resistant prostate cancer (CRPC) often shows histological evidence of neuroendocrine differentiation (NED). To evaluate the extent of NED in patients with CRPC, we used PET/CT with Ga-[DOTA-Tyr]-octreotate (Ga-DOTA-TATE), a somatostatin analog that binds somatostatin receptor 2 with high affinity. This radiotracer is used in imaging of neuroendocrine tumors. METHODS: Twelve patients (mean age, 65 [SD, 12] years) with CRPC were studied. Their mean prostate-specific antigen level at scanning was 85...
October 21, 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27769988/influencing-the-tumor-microenvironment-phase-2-study-of-copper-depletion-with-tetrathiomolybdate-in-high-risk-breast-cancer-and-preclinical-models-of-lung-metastases
#19
Nancy Chan, Amy Willis, Naomi Kornhauser, Maureen M Ward, Sharrell B Lee, Eleni Nackos, Bo Ri Seo, Ellen Chuang, Tessa Cigler, Anne Moore, Diana Donovan, Marta Vallee Cobham, Veronica Fitzpatrick, Sarah Schneider, Alysia Wiener, Jessica Guillaume-Abraham, Elnaz Anjom, Richard Zelkowitz, J David Warren, Maureen E Lane, Claudia Fischbach, Vivek Mittal, Linda Vahdat
PURPOSE: Bone marrow derived progenitor cells; including VEGFR2+ endothelial progenitor cells (EPCs) and copper-dependent pathways model the tumor microenvironment. We hypothesized that copper depletion (CD) using tetrathiomolybdate (TM) would reduce EPCs in high risk for relapse breast cancer (BC) patients (pts). We investigated the effect of TM on the tumor microenvironment in preclinical models. EXPERIMENTAL DESIGN: Stage 2 triple negative BC (TNBC), Stage 3 and stage 4 without any evidence of disease, (NED) BC pts, received oral TM to maintain ceruloplasmin (Cp) between 8-17mg/dL for 2 years or until relapse...
October 21, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27759966/nutrici%C3%A3-n-enteral-domiciliaria-en-la-regi%C3%A3-n-de-murcia-perfil-de-la-muestra-evoluci%C3%A3-n-del-coste-y-perspectiva-a%C3%A3-os-2007-2010
#20
Mercedes Ferrer Gómez, María Victoria García Zafra, Juan Ramón Cuenca Sánchez, Juan Francisco Sánchez Romera, Ana Aranda García, Víctor José Rausell Rausell, Antonio Miguel Hernández Martínez
Introducción: en Murcia, y hasta 2010, la administración de la nutrición enteral domiciliaria (NED) dictaba cumplir la regulación marcada en cuanto a los facultativos con competencias para su prescripción.Objetivos: examinar aspectos esenciales de este recurso en el periodo 2007-2010, características de la muestra y evolución del coste, así como perspectivas de futuro.Métodos: estudio del perfil de la población NED en un área de salud específica. Selección de recetas facturadas de productos NED en el conjunto de la Región, clasificación por tipos y análisis de la evolución en importe y en envases para el periodo 2007-2010...
September 20, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
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