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Primary cerebral diffuse large B cell lymphoma

A H Rudresha, Tamojit Chaudhuri, Kuntegowdanahalli C Lakshmaiah, Govind Babu, K N Lokesh, L K Rajeev
Background: Primary central nervous system lymphoma (PCNSL) is a rare form of aggressive extranodal non-Hodgkin's lymphoma which occurs in both immunocompromised and immunocompetent patients. It has an overall poor prognosis in spite of a multimodality treatment approach including chemotherapy and radiotherapy. This study attempts to further delineate the clinicopathological, immunohistochemical, and radiological profile of PCNSL at Kidwai Memorial Institute of Oncology, Karnataka, India...
October 2017: South Asian Journal of Cancer
S N Sovgirya, N I Vynnyk, A K Prylutsky, O A Tikhonova, I V Kornilova, I I Starchenko
The paper describes a case of primary extranodal diffuse large B-cell lymphoma of the cerebral hemispheres, which was regarded as an inflammatory disease of the brain during life and diagnosed only posthumously in the microscopically examination of the autopsy material by immunohistochemical studies.
2017: Arkhiv Patologii
Á de-Bonilla-Damiá, R Fernández-López, F J Capote-Huelva, F de la Cruz-Vicente, J J Egea-Guerrero, I Borrego-Dorado
OBJECTIVE: To study the usefulness of 18 F-FDG PET/CT in the initial evaluation and in the response assessment in primary brain lymphoma. MATERIAL AND METHODS: A retrospective analysis was carried out on 18 patients diagnosed with primary brain lymphoma, a histological subtype of diffuse large B-cell lymphoma, on whom an initial 18 F-FDG PET/CT and MRI was performed, with 7 of the cases being analysed after the completion of treatment in order to assess response and clinical follow up...
September 2017: Revista Española de Medicina Nuclear e Imagen Molecular
Ching Chung Ko, Ming Hong Tai, Chien Feng Li, Tai Yuan Chen, Jeon Hor Chen, Ginger Shu, Yu Ting Kuo, Yu Chang Lee
The differentiation between glioblastoma multiforme (GBM) and primary cerebral lymphoma (PCL) is important because the treatments are substantially different. The purpose of this article is to describe the MR imaging characteristics of GBM and PCL with emphasis on the quantitative ADC analysis in the tumor necrosis, the most strongly-enhanced tumor area, and the peritumoral edema. This retrospective cohort study collected 104 GBM (WHO grade IV) patients and 22 immune-competent PCL (diffuse large B cell lymphoma) patients...
2016: PloS One
Manuel Montesinos-Rongen, Frauke G Purschke, Anna Brunn, Caroline May, Eckhard Nordhoff, Katrin Marcus, Martina Deckert
Primary lymphoma of the CNS (PCNSL) is a diffuse large B cell lymphoma confined to the CNS. To elucidate its peculiar organ tropism, we generated recombinant Abs (recAbs) identical to the BCR of 23 PCNSLs from immunocompetent patients. Although none of the recAbs showed self-reactivity upon testing with common autoantigens, they recognized 1547 proteins present on a large-scale protein microarray, indicating polyreactivity. Interestingly, proteins (GRINL1A, centaurin-α, BAIAP2) recognized by the recAbs are physiologically expressed by CNS neurons...
August 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Jensen W J Ang, Arjun Khanna, Brian P Walcott, Kristopher T Kahle, Emad N Eskandar
We describe an atypical man with diffuse large B cell lymphoma localized to the sphenoid wing and adjacent cavernous sinus, initially presenting with isolated ipsilateral facial pain mimicking trigeminal neuralgia due to invasion of Meckel's cave but subsequently progressing to intra-axial extension and having synchronous features of systemic lymphoma. Primary central nervous system lymphoma is uncommon, accounting for approximately 2% of all primary intracranial tumors, but its incidence has been steadily increasing in some groups [1]...
July 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Zhaohua Gong, Ying Zhang, Hongjin Chu, Peiwen Lian, Liangming Zhang, Ping Sun, Jian Chen
Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painless priapism. On admission to Yantai Yuhuangding Hospital Affiliated to Qingdao University (Yantai, China), examination revealed an erect penis, enlarged lymph nodes in the bilateral inguinal and swelling in the thighs...
November 2014: Oncology Letters
Huseyin Mertsoylu, Sadik Muallaoglu, Ayberk Ali Besen, Suleyman Erdogdu, Ahmet Sezer, Ali Murat Sedef, Fatih Kose, Ali Arican, Ozgur Ozyilkan
BACKGROUND: The aim of this study was to assess the epidemiological and clinicopathological characteristics of primary extranodal non-Hodgkin's lymphoma (pENL) patients, focusing on treatment and survival outcome. MATERIALS AND METHODS: Between October 2003 and March 2012, 802 patients with non-Hodgkin's lymphoma (NHL) were diagnosed and treated in two different cancer centers of Southern Turkey. RESULTS: pENL, constituted 12.4% (100/802) of all NHL studied during this period...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Masanari Nonokuma, Yasuo Kuwabara, Koichi Takano, Kazuo Tamura, Kenji Ishitsuka, Kengo Yoshimitsu
OBJECTIVES: The aim of this study was to clarify the characteristics of regional cerebral glucose metabolic abnormalities in patients with malignant lymphoma of the body using statistical image analyses. Post-therapeutic changes in cerebral glucose metabolism were also evaluated. METHODS: The subjects consisted of 30 patients, including 16 patients with diffuse large B-cell lymphoma and 14 patients with other types of lymphoma. Patients with primary cerebral lymphoma were excluded from this study...
December 2014: Annals of Nuclear Medicine
Kimberly Funaro, Katie C Bailey, Sadie Aguila, Steven J Agosti, Christopher Vaillancourt
We report a case of primary central nervous system lymphoma presenting as multiple intraventricular masses in an immunocompetent 68 year old man with severe headache and unsteady gait. The diagnosis was obtained by analysis of the cerebrospinal fluid and subsequent surgical biopsy. This is an unusual appearance for primary central nervous lymphoma, with the majority of the cases presenting as solitary masses.
March 2014: Journal of Radiology Case Reports
Myeong-Jin Ko, Sung-Nam Hwang, Yong-Sook Park, Teak Kyun Nam
Bone involvement is a common finding in many types of lymphomas, particularly in advanced stages. However, cranial vault affliction has been regarded as an exceedingly rare presentation. Here, we report the case of a patient with cranial vault lymphoma who presented with a scalp mass. An 81-year-old woman presented with a gradually growing and non-painful frontal scalp mass that she noticed one month before admission. It was a flatly elevated, round mass measuring about 6×4×4 cm. Computed tomography and magnetic resonance imaging of the brain revealed a contrast-enhancing intracranial extradural mass at the counter-location of the scalp mass...
April 2013: Brain Tumor Research and Treatment
Aneel Myageri, U G Vandana, Sateesh Melkundi, Preetam B Patil, Padmaja Kulkarni
The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections...
October 2013: Asian Journal of Neurosurgery
Shiro Yamamoto, Seiji Nagano, Sumiya Shibata, Takeharu Kunieda, Yukihiro Imai, Nobuo Kohara
A 66-year-old man presented with deteriorated bradykinesia, gait disturbance, disorientation, and urinary incontinence for three weeks. Magnetic resonance imaging (MRI) showed dilatation of the ventricles. Cerebrospinal fluid (CSF) examination demonstrated lymphocytic pleocytosis, elevation of protein levels, and decreased of glucose levels. A gadolinium-enhanced MRI revealed lesions in the ventricular wall and choroid plexus, mimicking ventriculitis. No evidence of bacterial, fungal, mycobacterial, or viral infections were observed in the CSF...
2013: Rinshō Shinkeigaku, Clinical Neurology
Jinfeng Zheng, Jiagang Xu, Shufang Ma, Xiyan Sun, Ming Geng, Lin Wang
We studied the clinicopathological and imaging characteristics of primary central nervous system diffuse large B-cell lymphomas (PCNS-DLBCL). Imaging, pathologic histology, and immunohistochemical staining characteristics were analyzed, and the immunoglobulin heavy and light chain gene rearrangement of 25 PCNS-DLBCL cases was examined. MicroRNA was extracted from 10 cases each of PCNS-DLBCL, extracerebral germinal center DLBCL (GC-DLBCL), and extracerebral non-GC-DLBCL (NGC-DLBCL); we conducted chip hybridization and comparatively analyzed the difference among the three...
2013: International Journal of Clinical and Experimental Pathology
Junko Matsuyama, Masahiro Ichikawa, Tomoyoshi Oikawa, Taku Sato, Yugo Kishida, Keiko Oda, Takuya Maeda, Masayuki Yamada, Yosuke Kuromi, Yuka Matsumoto, Hitoshi Ando, Jun Sakuma, Kiyoshi Saito
We report 2 cases of primary central nervous system (CNS) lymphoma arising in the region of the optic nerve. For both patients, diagnosis of lymphoma was impossible without histological examination because of the rarity of the lymphoma location. The first case involved an 84-year-old woman who developed loss of vision and hypopituitarism. Intraoperative finding was optic glioma; histological diagnosis was diffuse large B cell lymphoma, however. The second case involved a 67-year-old man who developed loss of vision...
July 2014: Brain Tumor Pathology
Rym Ben Abdelwahed, Sabrina Donnou, Hanane Ouakrim, Lucile Crozet, Jérémie Cosette, Alexandra Jacquet, Isabel Tourais, Bénédicte Fournès, Mélanie Gillard Bocquet, Amine Miloudi, Valérie Touitou, Cécile Daussy, Marie-Christine Naud, Wolf Herman Fridman, Catherine Sautès-Fridman, Rémi Urbain, Sylvain Fisson
PURPOSE: Primary cerebral lymphoma (PCL) and primary intraocular lymphoma (PIOL) belong to the systemic diffuse large B-cell lymphoma family and are characterized by the presence of CD20(+) lymphoma B cells in the brain or the eye. These highly aggressive malignancies have a poor prognosis and no specific therapy. The presence of effector immune cells in the damaged brain and vitreous suggests that treatment with anti-human CD20 (hCD20) monoclonal antibodies might be effective. We developed murine models of PCL and PIOL to assess the intracerebral and intraocular antitumor effect of ublituximab, a promising glycoengineered anti-hCD20 mAb with a high affinity for FcγRIIIa (CD16) receptors...
May 2013: Investigative Ophthalmology & Visual Science
Wadad Sami Mneimneh, Muhammad Ameen Ashraf, Li Li, Osama El-Kadi, Jiang Qian, Tipu Nazeer, Alida Hayner-Buchan
Spinal primary dural lymphoma (PDL) is uncommon with a total of 37 previous well-documented cases reported, including one diagnosed in the authors' institution. More recently we encountered an additional case of spinal PDL that, similarly to our previous case, was grade 1-2 follicular B-cell PDL. Our two cases were diagnosed over a 3-year interval in a 72-year-old female and a 74-year-old male, respectively. An exhaustive literature review on PDL was performed consequently to reveal that: (i) spinal and cerebral sites of involvement by PDL are constantly mutually exclusive; and (ii) unlike cerebral PDL, which is usually of marginal zone B-cell type, only two of the 38 cases of spinal PDL were diagnosed as such, diffuse large B-cell lymphoma being the most commonly encountered type in the spine...
January 2013: Pathology International
Mitsuru Watanabe, Hitoshi Satoi, Yuki Takahashi, Namiko Nishida, Hiroki Toda, Sadayuki Matsumoto
Lymphomatosis cerebri (LC) is a rare form of primary central nervous system lymphoma characterized by subacute progressive dementia and unsteady gait. MRI study of LC typically reveals diffuse leukoencephalopathy without contrast enhancement. The clinical presentation and MRI features of LC can resemble infectious, inflammatory, toxic or vascular leukoencephalopathy. Hence diagnosis of LC is easily mistaken for other, more common diseases. In this report, we present a case of a 55-year-old man presenting with subacute progressive dementia and ataxic gait...
2012: Rinshō Shinkeigaku, Clinical Neurology
Soutarou Taguchi, Jun-ichi Niwa, Keisuke Tokui, Tomoko Nishikawa, Yuko Ichikawa, Manabu Doyu
A 45-year-old man presented with fever, progressive mutism and memory loss, was admitted to our hospital. MR imaging and angiography suggested multiple foci of infarctions and vasculitis without Gadrinium-enhancement. CSF examination revealed pleocytosis with mononuclear cell dominance and elevated protein content. Adenosine deaminase activity was accelerated, and no malignant cell was found. Whole body CT imaging and Garium-scintigraphy were normal. Under the clinical diagnosis of tuberculous meningitis, anti-tubercular drugs with steroid were administered, resulting in marked attenuation of his neurological impairments...
2012: Rinshō Shinkeigaku, Clinical Neurology
Elisabeth B Marsh, Steven R Zeiler, Michael Levy, Rafael H Llinas, Victor C Urrutia
INTRODUCTION: Primary central nervous system vasculitis (PCNSV) is a rare inflammatory arteriopathy confined to the brain, spinal cord, and leptomeninges. Because of its nonspecific presentation and difficulties in making a positive diagnosis, empiric treatment is often instituted. CASE SERIES: We report a case series of 5 patients who were admitted or transferred to the Johns Hopkins Hospital with a clinical history and magnetic resonance imaging findings suggestive of PCNSV...
July 2012: Neurologist
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