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Kruppel

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https://www.readbyqxmd.com/read/29452083/tribolium-castaneum-gene-expression-changes-after-paranosema-whitei-infection
#1
Alberto Lopez-Ezquerra, Andreas Mitschke, Erich Bornberg-Bauer, Gerrit Joop
BACKGROUND: Microsporidia are obligate parasites that possess some of the smallest eukaryotic genomes. Several insect species are susceptible to infections by microsporidian parasites. Paranosema whitei frequently infects young larvae of Tribolium castaneum and obligately kills the host whereupon transmission to subsequent hosts is accomplished via spores. P. whitei infection results in developmental arrest of T. castaneum, preventing larvae from pupation. The mechanisms underlying P...
February 13, 2018: Journal of Invertebrate Pathology
https://www.readbyqxmd.com/read/29448248/lncrna-gas5-overexpression-reverses-lps-induced-inflammatory-injury-and-apoptosis-through-up-regulating-klf2-expression-in-atdc5-chondrocytes
#2
Feng Li, Jianguang Sun, Shilei Huang, Gao Su, Guofu Pi
BACKGROUND/AIMS: Osteoarthritis (OA) is the most frequently occurring joint disease and characterized by degeneration of cartilage. As the unique cell type in cartilage, chondrocytes play a crucial role during OA. Our study explored the influence of long non-coding RNA (lncRNA) growth arrest-specific transcript 5 (GAS5) on lipopolysaccharides (LPS)-induced injury in ATDC5 cells. METHODS: Cell viability, apoptosis and expression of inflammatory cytokines were all assessed to evaluate LPS-induce inflammatory injury...
February 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29435939/application-of-tale-based-approach-for-dissecting-functional-microrna-302-367-in-cellular-reprogramming
#3
Zhonghui Zhang, Wen-Shu Wu
MicroRNAs are small 18-24 nt single-stranded noncoding RNA molecules involved in many biological processes, including stemness maintenance and cellular reprogramming. Current methods used in loss-of-function studies of microRNAs have several limitations. Here, we describe a new approach for dissecting miR-302/367 functions by transcription activator-like effectors (TALEs), which are natural effector proteins secreted by Xanthomonas and Ralstonia bacteria. Knockdown of the miR-302/367 cluster uses the Kruppel-associated box repressor domain fused with specific TALEs designed to bind the miR-302/367 cluster promoter...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29435049/med28-increases-the-colony-forming-ability-of-breast-cancer-cells-by-stabilizing-the-znf224-protein-upon-dna-damage
#4
Jin Gu Cho, Key-Hwan Lim, Sang Gyu Park
The regulation of gene expression by transcription factors serves a critical function in cell proliferation. Zinc-finger protein 224 (ZNF224), a Krüppel-associated-box-containing zinc finger protein, is known to serve a crucial function in integrating the transcriptional co-factors that activate transcriptional regulation pathways in the cell. A previous study demonstrated that ZNF224 enhances cell proliferation by downregulating the expression of p21 and p53. The present study identified mediator complex subunit 28 (MED28) as a potential binding partner for ZNF224; this was confirmed by co-immunoprecipitation and a surface plasmon resonance assay...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29432497/autologous-t-cells-expressing-the-oncogenic-transcription-factor-klf6-sv1-prevent-apoptosis-of-chronic-lymphocytic-leukemia-cells
#5
Parviz Kokhaei, Mohammad Hojjat-Farsangi, Fariba Mozaffari, Ali Moshfegh, Fatemeh Pak, Ali Rashidy-Pour, Marzia Palma, Lotta Hansson, Anders Österborg, Håkan Mellstedt
Crosstalk between leukemic cells and the tumor microenvironment is of importance in chronic lymphocytic leukemia (CLL). T cells seem to sustain the survival of CLL cells by various mechanisms. The Krüppel-like family of transcription factors (KLFs) are identified as regulators of proliferation and cell death. In the present study, we analyzed the expression of the wild type (WT) gene KLF6 and the oncogenic splice variant 1 (KLF6-SV1) at the mRNA level in subsets of T cells from CLL patients (n = 29), multiple myeloma patients (n = 6) and normal donors (n = 10)...
2018: PloS One
https://www.readbyqxmd.com/read/29425818/dna-methylation-of-the-klf14-gene-region-on-whole-blood-provide-prediction-for-the-chronic-inflammation-at-the-adipose-tissue
#6
Chihiro Iwaya, Hidetoshi Kitajima, Ken Yamamoto, Yasutaka Maeda, Noriyuki Sonoda, Hiroki Shibata, Toyoshi Inoguchi
Krüppel-Like Factor 14 (KLF14) gene, which appears to be a master regulator of gene expression on the adipose tissue and have previously been associated with BMI and Type 2 diabetes (T2D) by large GWAS studies. In order to find predictive biomarkers for the development of T2D, it is necessary to take into account changes in the epigenome affected by environmental factors. This study focused on aging and obesity, which are T2D risk factor, and examines epigenetic changes and inflammatory changes. Thus we investigated DNA methylation change at Klf14 promoter region of different organs using mice for comparing aging and weight...
February 6, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29420372/mutation-screening-of-the-kr%C3%A3-ppel-like-factor-1-gene-in-individuals-with-increased-fetal-hemoglobin-referred-for-hemoglobinopathy-investigation-in-south-of-iran
#7
Mohammad Hamid, Sanaz Ershadi Oskouei, Gholamreza Shariati, Esmaeil Babaei, Hamid Galehdari, Alihossein Saberi, Alireza Sedaghat
BACKGROUND: Any mutation in the Krüppel-like factor 1 (KLF1) gene may interfere with its proper related function in the erythropoiesis process and lead to alterations in proper activation of its downstream protein through globin switching, which results in an increase in fetal hemoglobin (HbF). This study aimed to investigate whether KLF1 mutation can associate with high level of HbF in individuals with increased fetal hemoglobin referred for screening of hemoglobinopathies in south of Iran...
February 7, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29414921/microrna-125a-5p-affects-adipocytes-proliferation-differentiation-and-fatty-acid-composition-of-porcine-intramuscular-fat
#8
Jingjing Du, Yan Xu, Peiwen Zhang, Xue Zhao, Mailin Gan, Qiang Li, Jideng Ma, Guoqing Tang, Yanzhi Jiang, Jinyong Wang, Xuewei Li, Shunhua Zhang, Li Zhu
Intramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism of porcine IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in porcine intramuscular adipogenesis. Previously, microRNA-125a-5p (miR-125a-5p) was identified as an important regulator of adipogenesis. In the present study, we found that the expression of miR-125a-5p is dynamically regulated during porcine intramuscular preadipocytes differentiation and that its expression levels in different porcine muscle tissues were negatively involved with IMF content...
February 7, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29410288/identification-of-key-micrornas-transcription-factors-and-genes-associated-with-congenital-obstructive-nephropathy-in-a-mouse-model-of-megabladder
#9
Guangda Xin, Rui Chen, Xiaofei Zhang
OBJECTIVE: The present study aimed to investigate the molecular mechanism underlying congenital obstructive nephropathy (CON). METHODS: The microarray dataset GSE70879 was downloaded from the Gene Expression Omnibus, including 3 kidney samples of megabladder mice and 4 control kidneys. Using this dataset, differentially expressed miRNAs (DEMs) were identified between the kidney samples from megabladder mice and controls, followed by identification of the target genes for these DEMs and construction of a DEM and target gene interaction network...
February 1, 2018: Gene
https://www.readbyqxmd.com/read/29408889/kruppel-like-factor-15-is-required-for-the-cardiac-adaptive-response-to-fasting
#10
Keiki Sugi, Paishiun N Hsieh, Olga Ilkayeva, Shamanthika Shelkay, Bridget Moroney, Palvir Baadh, Browning Haynes, Megan Pophal, Liyan Fan, Christopher B Newgard, Domenick A Prosdocimo, Mukesh K Jain
Cardiac metabolism is highly adaptive in response to changes in substrate availability, as occur during fasting. This metabolic flexibility is essential to the maintenance of contractile function and is under the control of a group of select transcriptional regulators, notably the nuclear receptor family of factors member PPARα. However, the diversity of physiologic and pathologic states through which the heart must sustain function suggests the possible existence of additional transcriptional regulators that play a role in matching cardiac metabolism to energetic demand...
2018: PloS One
https://www.readbyqxmd.com/read/29408733/bioinformatics-analysis-of-non-synonymous-variants-in-the-klf-genes-related-to-cardiac-diseases
#11
Katyana Kaline Silva Ferreira, Enéas Ricardo de Morais Gomes, José Luiz de Lima Filho, Carlos Henrique Madeiros Castelletti, Danyelly Bruneska Gondim Martins
Kruppel-like Factors (KLF) are responsible for regulating many genes involved in physiological and pathological processes. They are characterized by three conserved zinc-fingers in the DNA-binding domain, wherein mutations could affect the binding efficiency and transcription regulation. This study aimed to perform bioinformatics analysis to determine the most deleterious non-synonymous variants in KLFs involved in cardiac development and diseases, and their effects over the protein structure and stability...
January 31, 2018: Gene
https://www.readbyqxmd.com/read/29407891/fluid-shear-stress-regulates-the-expression-of-lectin-like-oxidized-low-density-lipoprotein-receptor-1-via-klf2-ap-1-pathway-depending-on-its-intensity-and-pattern-in-endothelial-cells
#12
Ji Yoon Lee, Jihwa Chung, Kyoung Hwa Kim, Shung Hyun An, Minsuk Kim, Junbeom Park, Kihwan Kwon
BACKGROUND AND AIMS: Vascular endothelial cells (ECs) are exposed to fluid shear stress (FSS), which modulates vascular pathophysiology. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) is crucial in endothelial dysfunction and atherosclerosis. We elucidated the mechanism regulating LOX-1 expression in ECs by FSS. METHODS: Human umbilical vein endothelial cells were exposed to laminar shear stress (LSS) of indicated intensities using a unidirectional steady flow, or to oscillatory shear stress (OSS) using a bidirectional disturbed flow...
January 31, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29397868/sf3b4-as-an-early-stage-diagnostic-marker-and-driver-of-hepatocellular-carcinoma
#13
Qingyu Shen, Suk Woo Nam
An accurate diagnostic marker for detecting early-stage hepatocellular carcinoma (eHCC) is clinically important, since early detection of HCC remarkably improves patient survival. From the integrative analysis of the transcriptome and clinicopathologic data of human multi-stage HCC tissues, we were able to identify barrier-to-autointegration factor 1 (BANF1), procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (PLOD3) and splicing factor 3b subunit 4 (SF3B4) as early HCC biomarkers which could be detected in precancerous lesions of HCC, with superior capabilities to diagnose eHCC compared to the currently popular HCC diagnostic biomarkers: GPC3, GS, and HSP70...
February 5, 2018: BMB Reports
https://www.readbyqxmd.com/read/29379553/klf1-gene-and-borderline-hemoglobin-a2-in-saudi-population
#14
J Francis Borgio, Sayed AbdulAzeez, Ahmed M Al-Muslami, Zaki A Naserullah, Sana Al-Jarrash, Ahmed M Al-Suliman, Mohammed S Al-Madan, Amein K Al-Ali
Introduction: Elevated HbA2 (hemoglobin A2) level is considered the most reliable hematological parameter for the detection of β-thalassemia carriers. However, some carriers are difficult to recognize because the level of HbA2 is not in the distinctive carrier range, i.e. 4.0-6.0%; instead, some carriers have HbA2 levels between normal and carrier levels, i.e. borderline HbA2 (HbA2 = 3.1-3.9%). Studies have shown that variations in the erythroid Krüppel-like factor (KLF1) gene lead to borderline HbA2 in β-thalassemia carriers from various populations...
January 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29374155/kruppel-like-factor-4-dependent-staufen1-mediated-mrna-decay-regulates-cortical-neurogenesis
#15
Byoung-San Moon, Jinlun Bai, Mingyang Cai, Chunming Liu, Jiandang Shi, Wange Lu
Kruppel-like factor 4 (Klf4) is a zinc-finger-containing protein that plays a critical role in diverse cellular physiology. While most of these functions attribute to its role as a transcription factor, it is postulated that Klf4 may play a role other than transcriptional regulation. Here we demonstrate that Klf4 loss in neural progenitor cells (NPCs) leads to increased neurogenesis and reduced self-renewal in mice. In addition, Klf4 interacts with RNA-binding protein Staufen1 (Stau1) and RNA helicase Ddx5/17...
January 26, 2018: Nature Communications
https://www.readbyqxmd.com/read/29371932/identification-of-novel-genes-in-aging-osteoblasts-using-next-generation-sequencing-and-bioinformatics
#16
Yi-Jen Chen, Wei-An Chang, Ming-Shyan Huang, Chia-Hsin Chen, Kuan-Yuan Wang, Ya-Ling Hsu, Po-Lin Kuo
During the aging process, impaired osteoblastic function is one key factor of imbalanced bone formation and age-related bone loss. The aim of this study is to explore the differentially expressed genes in normal and aged osteoblasts and to identify genes potentially involved in age-related alteration in bone physiology. Based on next generation sequencing and bioinformatics analysis, 12 differentially expressed microRNAs and 22 differentially expressed genes were identified. Up-regulation of miR-204-5p was validated in an array of osteoporotic hip fracture in the Gene Expression Omnibus database (GSE74209)...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29367428/kr%C3%A3-ppel-like-factor-4-suppresses-serine-threonine-kinase-33-activation-and-metastasis-of-gastric-cancer-through-reversing-epithelial-mesenchymal-transition
#17
Keping Xie, Fanyang Kong, Tao Sun, Xiangyu Kong, Dacheng Xie, Zhaoshen Li
PURPOSE: Cancers with aberrant expression of Serine/threonine kinase 33 (STK33) is particularly aggressive. However, its expression, clinical significance and biological functions in gastric cancer remain largely unknown. In the present study, we determined the expression and function of STK33 in gastric cancer and delineated the clinical significance of Krüppel-like factor 4 (KLF4) /STK33 signaling pathway. EXPERIMENTAL DESIGN: STK33 expression and its association with multiple clinicopathologic characteristics were analyzed immunohistochemically in human gastric cancer specimens...
January 24, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29356943/inhibition-of-klf7-targeting-microrna-146b-promotes-sciatic-nerve-regeneration
#18
Wen-Yuan Li, Wei-Ting Zhang, Yong-Xia Cheng, Yan-Cui Liu, Feng-Guo Zhai, Ping Sun, Hui-Ting Li, Ling-Xiao Deng, Xiao-Feng Zhu, Ying Wang
A previous study has indicated that Krüppel-like factor 7 (KLF7), a transcription factor that stimulates Schwann cell (SC) proliferation and axonal regeneration after peripheral nerve injury, is a promising therapeutic transcription factor in nerve injury. We aimed to identify whether inhibition of microRNA-146b (miR-146b) affected SC proliferation, migration, and myelinated axon regeneration following sciatic nerve injury by regulating its direct target KLF7. SCs were transfected with miRNA lentivirus, miRNA inhibitor lentivirus, or KLF7 siRNA lentivirus in vitro...
January 22, 2018: Neuroscience Bulletin
https://www.readbyqxmd.com/read/29348873/impaired-epidermal-langerhans-cell-maturation-in-tgf%C3%AE-inducible-early-gene-1-tieg1-knockout-mice
#19
Xilin Zhang, Yi Yao, Wei-Zen Wei, Zeng-Quan Yang, Jun Gu, Li Zhou
TGF-β-inducible early gene 1 (TIEG1), also known as Krüppel-like factor 10 (Klf10), represents a major downstream transcription factor of transforming growth factor-β1 (TGF-β1) signaling. Epidermal Langerhans cells (LCs), a unique subpopulation of dendritic cells (DC), essentially mediates immune surveillance and tolerance. TGF-β1 plays a pivotal role in LC maintenance and function after birth, although the underpinning mechanisms remain elusive. Here, we hypothesized that TIEG1 might be involved in TGF-β1-mediated LC homeostasis and function...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29348684/mithramycin-a-suppresses-basal-triple-negative-breast-cancer-cell-survival-partially-via-down-regulating-kr%C3%A3-ppel-like-factor-5-transcription-by-sp1
#20
Rong Liu, Xu Zhi, Zhongmei Zhou, Hailin Zhang, Runxiang Yang, Tianning Zou, Ceshi Chen
As the most malignant breast cancer subtype, triple-negative breast cancer (TNBC) does not have effective targeted therapies clinically to date. As a selective Sp1 inhibitor, Mithramycin A (MIT) has been reported to have anti-tumor activities in multiple cancers. However, the efficacy and the mechanism of MIT in breast cancer, especially TNBC, have not been studied. In this study, we demonstrated that MIT suppressed breast cancer cell survival in a dosage-dependent manner. Interestingly, TNBC cells were more sensitive to MIT than non-TNBC cells...
January 18, 2018: Scientific Reports
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