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https://www.readbyqxmd.com/read/29230002/deficiency-in-interferon-type-1-receptor-improves-definitive-erythropoiesis-in-klf1-null-mice
#1
Maria Francesca Manchinu, Carla Brancia, Cristian Antonio Caria, Ester Musu, Susanna Porcu, Michela Simbula, Isadora Asunis, Lucia Perseu, Maria Serafina Ristaldi
A key regulatory gene in definitive erythropoiesis is the transcription factor Krüppel-like factor 1 (Klf1). Klf1 null mice die in utero by day 15.5 (E15.5) due to impaired definitive erythropoiesis and severe anemia. Definitive erythropoiesis takes place in erythroblastic islands in mammals. Erythroblastic islands are formed by a central macrophage (Central Macrophage of Erythroblastic Island, CMEI) surrounded by maturating erythroblasts. Interferon-β (IFN-β) is activated in the fetal liver's CMEI of Klf1 null mice...
December 11, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29221447/disruption-of-postnatal-folliculogenesis-and-development-of-ovarian-tumor-in-a-mouse-model-with-aberrant-transforming-growth-factor-beta-signaling
#2
Yang Gao, Xin Fang, David F Vincent, David W Threadgill, Laurent Bartholin, Qinglei Li
BACKGROUND: Transforming growth factor beta (TGFB) superfamily signaling is implicated in the development of sex cord-stromal tumors, a category of poorly defined gonadal tumors. The aim of this study was to determine potential effects of dysregulated TGFB signaling in the ovary using Cre recombinase driven by growth differentiation factor 9 (Gdf9) promoter known to be expressed in oocytes. METHODS: A mouse model containing constitutively active TGFBR1 (TGFBR1CA) using Gdf9-iCre (termed TGFBR1-CAG9Cre) was generated...
December 8, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/29212231/zbp-89-function-in-colonic-stem-cells-and-during-butyrate-induced-senescence
#3
Ramon Ocadiz-Ruiz, Amanda L Photenhauer, Michael M Hayes, Lin Ding, Eric R Fearon, Juanita L Merchant
ZBP-89 (Zfp148, ZNF148) is a Kruppel-type zinc-finger family transcription factor that binds to GC-rich DNA elements. Earlier studies in cell lines demonstrated that ZBP-89 cooperates with Wnt β-catenin signaling by inducing β-catenin gene expression. Since β-catenin levels are normally highest at the crypt base, we examined whether ZBP-89 is required for stem cell maintenance. Lineage-tracing using a Zfp148CreERT2 transgenic line demonstrated expression in both intestine and colonic stem cells. Deleting the Zfp148 locus in the colon using the Cdx2NLSCreERT2 transgene, reduced the size and number of polyps formed in the Apc-deleted mice...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29212199/klf4-reduces-stemness-phenotype-triggers-mesenchymal-epithelial-transition-met-like-molecular-changes-and-prevents-tumor-progression-in-nasopharygeal-carcinoma
#4
Xiqing Li, Zhunlan Zhao, Xiaoling Zhang, Sheng Yang, Xia Lin, Xinglong Yang, Xiaolin Lin, Junwen Shi, Shengchun Wang, Wentao Zhao, Jing Li, Fei Gao, Mingyue Liu, Ning Ma, Weiren Luo, Kaitai Yao, Yan Sun, Shengjun Xiao, Dong Xiao, Junshuang Jia
The reprogramming factor Krüppel-like factor 4 (Klf4), one of the Yamanaka's reprogramming factors, plays an essential role in reprogramming somatic cells into induced pluripotent stem cells (iPSCs). Klf4 is dysregulated and displays divergent functions in multiple malignancies, but the biological roles of Klf4 in nasopharyngeal carcinoma (NPC) remain unknown. The present study revealed that Klf4 downregulation in a cohort of human NPC biopsies is significantly associated with invasive and metastatic phenotypes of NPC...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207157/microarray-analysis-reveals-gene-and-microrna-signatures-in-diabetic-kidney-disease
#5
Chengji Cui, Yabin Cui, Yanyan Fu, Sichao Ma, Shoulin Zhang
The current study aimed to identify therapeutic gene and microRNA (miRNA) biomarkers for diabetic kidney disease (DKD). The public expression profile GSE30122 was used. Following data preprocessing, the limma package was used to select differentially-expressed genes (DEGs) in DKD glomeruli samples and tubuli samples and they were compared with corresponding controls. Then overlapping DEGs in glomeruli and tubuli were identified and enriched analysis was performed. In addition, protein‑protein interaction (PPI) network analysis as well as sub‑network analysis was conducted...
November 28, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29207095/upregulation-of-zbtb7a-exhibits-a-tumor-suppressive-role-in-gastric-cancer-cells
#6
Guang Sun, Bo Peng, Quan Xie, Jianwen Ruan, Xianwen Liang
Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer‑associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29203643/the-n-terminal-cchc-zinc-finger-motif-mediates-homodimerization-of-the-transcription-factor-bcl11b
#7
Piotr Grabarczyk, Passorn Winkler, Martin Delin, Praveen K Sappa, Sander Bekeschus, Petra Hildebrandt, Grzegorz K Przybylski, Uwe Völker, Elke Hammer, Christian A Schmidt
The BCL11B gene encodes a Krüppel-like, sequence-specific zinc finger transcription factor that acts as either a repressor or an activator, depending on its post-translational modifications. The importance of BCL11B in numerous biological processes in multiple organs has been well established in mouse knockout models. The phenotype of the first de novo monoallelic germline missense mutation in the BCL11B gene (N441K) strongly implies that the mutant protein acts in a dominant negative manner by neutralizing the unaffected protein through the formation of a nonfunctional dimer...
December 4, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29203245/klf4-protects-brain-microvascular-endothelial-cells-from-ischemic-stroke-induced-apoptosis-by-transcriptionally-activating-malat1
#8
Haojie Yang, Xixiang Xi, Bin Zhao, Zhenxi Su, Zhenyi Wang
In this study, we investigated the expression profile and functional role of Kruppel-like family of transcription factor 4 (KLF4) in mouse cerebral microvascular endothelial cells (MECs) after focal cerebral ischemia and in cultured b.End3 cells after oxygen-glucose deprivation (OGD). Its downstream regulation was also studied. Our data showed that KLF4 was significantly upregulated in the cerebral MECs after transient ischemic insult and in cultured b.End3 cells after 24 h OGD exposure. In in vitro b.End3 cell model, KLF4 shRNA significantly increased OGD-induced activation of caspase-3 and also increased OGD-induced b...
December 1, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29198826/trim28-and-interacting-krab-znfs-control-self-renewal-of-human-pluripotent-stem-cells-through-epigenetic-repression-of-pro-differentiation-genes
#9
Urszula Oleksiewicz, Marta Gładych, Ayush T Raman, Holger Heyn, Elisabetta Mereu, Paula Chlebanowska, Anastazja Andrzejewska, Barbara Sozańska, Neha Samant, Katarzyna Fąk, Paulina Auguścik, Marcin Kosiński, Joanna P Wróblewska, Katarzyna Tomczak, Katarzyna Kulcenty, Rafał Płoski, Przemysław Biecek, Manel Esteller, Parantu K Shah, Kunal Rai, Maciej Wiznerowicz
Reprogramming to induced pluripotent stem cells (iPSCs) and differentiation of pluripotent stem cells (PSCs) are regulated by epigenetic machinery. Tripartite motif protein 28 (TRIM28), a universal mediator of Krüppel-associated box domain zinc fingers (KRAB-ZNFs), is known to regulate both processes; however, the exact mechanism and identity of participating KRAB-ZNF genes remain unknown. Here, using a reporter system, we show that TRIM28/KRAB-ZNFs alter DNA methylation patterns in addition to H3K9me3 to cause stable gene repression during reprogramming...
November 28, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29196317/an-image-based-mirna-screen-identifies-mirna-135s-as-regulators-of-cns-axon-growth-and-regeneration-by-targeting-kr%C3%A3-ppel-like-factor-4
#10
Eljo Y van Battum, Marieke G Verhagen, Vamshidhar R Vangoor, Yuki Fujita, Alwin A H A Derijck, Eoghan O'Duibhir, Giuliano Giuliani, Thijs de Gunst, Youri Adolfs, Daphne Lelieveld, David Egan, Roel Q J Schaapveld, Toshihide Yamashita, R Jeroen Pasterkamp
During embryonic development, axons extend over long distances to establish functional connections. In contrast, axon regeneration in the adult mammalian central nervous system (CNS) is limited, in part by a reduced intrinsic capacity for axon growth. Therefore, insight into the intrinsic control of axon growth may provide new avenues for enhancing CNS regeneration. Here, we performed one of the first miRNome-wide functional miRNA screens to identify microRNAs (miRNAs) with robust effects on axon growth. High-content screening identified miR-135a and miR-135b as potent stimulators of axon growth and cortical neuron migration in vitro and in vivo in male and female mice...
December 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29196238/tgf-%C3%AE-synergizes-with-ml264-to-block-il-1%C3%AE-induced-matrix-degradation-mediated-by-kr%C3%A3-ppel-like-factor-5-in-the-nucleus-pulposus
#11
Zi'ang Xie, Zhiwei Jie, Gangliang Wang, Xuewu Sun, Pan Tang, Shuai Chen, An Qin, Jian Wang, Shunwu Fan
Intervertebral disc degeneration causes low back pain.Interleukin-1β (IL-1β) is a well-known inflammatory mediator that is involved in disc degeneration but its molecular mechanisms on catabolic and anabolic events in nucleus pulposus (NP) cells remain unclear. Krüppel-like factor 5 (KLF5) is associated with inflammation and was previously shown to cause cartilage degradation. In this study, we revealed that KLF5 is involved in IL-1β activated NF-kB cascade by enhancing both p65 phosphorylation and p65 acetylation...
November 28, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29191928/sustained-activation-of-rho-gtpases-promotes-a-synthetic-pulmonary-artery-smooth-muscle-cell-phenotype-in-neprilysin-null-mice
#12
Vijaya Karoor, Mehdi A Fini, Zoe Loomis, Timothy Sullivan, Louis B Hersh, Evgenia Gerasimovskaya, David Irwin, Edward C Dempsey
OBJECTIVE: Pulmonary artery smooth muscle cells (PASMCs) from neprilysin (NEP) null mice exhibit a synthetic phenotype and increased activation of Rho GTPases compared with their wild-type counterparts. Although Rho GTPases are known to promote a contractile SMC phenotype, we hypothesize that their sustained activity decreases SM-protein expression in these cells. APPROACH AND RESULTS: PASMCs isolated from wild-type and NEP-/- mice were used to assess levels of SM-proteins (SM-actin, SM-myosin, SM22, and calponin) by Western blotting, and were lower in NEP-/- PASMCs compared with wild-type...
November 30, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29191808/suberanilohydroxamic-acid-as-a-pharmacological-kruppel-like-factor-2-activator-that-represses-vascular-inflammation-and-atherosclerosis
#13
Yanni Xu, Suowen Xu, Peng Liu, Marina Koroleva, Shuya Zhang, Shuyi Si, Zheng Gen Jin
BACKGROUND: Kruppel-like factor 2 (KLF2) is an important zinc-finger transcription factor that maintains endothelial homeostasis by its anti-inflammatory, -thrombotic, -oxidative, and -proliferative effects in endothelial cells. In light of the potent vasoprotective effects of KLF2, modulating KLF2 expression or function could give rise to new therapeutic strategies to treat cardiovascular diseases. METHODS AND RESULTS: High-throughput drug screening based on KLF2 promoter luciferase reporter assay was performed to screen KLF2 activators...
November 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29186807/the-poz-btb-and-at-hook-containing-zinc-finger-1-patz1-transcription-regulator-physiological-functions-and-disease-involvement
#14
REVIEW
(no author information available yet)
PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) and human diseases. Here we summarize these studies with a focus on the PATZ1 emerging and controversial role in cancer, where it acts as either a tumor suppressor or an oncogene...
November 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29181170/role-of-kr%C3%A3-ppel-like-factor-4-and-heat-shock-protein-27-in-cancer-of-the-larynx
#15
Jihad Karam, Marie Claude Fadous-Khalifé, Rita Tannous, Sally Fakhreddine, Marcel Massoud, Joseph Hadchity, Georges Aftimos, Elie Hadchity
Late detection and lack of standard treatment strategies in larynx cancer patients result in high levels of mortality and poor prognosis. Prognostic stratification of larynx cancer patients based on molecular prognostic tumor biomarkers may lead to more efficient clinical management. Krüppel-like factor 4 (KLF4) and Heat Shock Protein 27 (HSP27) have an important role in tumorigenesis and are considered promising candidate biomarkers for various types of cancer. However, their role in larynx carcinoma remains to be elucidated...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29180716/drosophila-kruppel-homolog-1-represses-lipolysis-through-interaction-with-dfoxo
#16
Ping Kang, Kai Chang, Ying Liu, Mark Bouska, Allison Birnbaum, Galina Karashchuk, Rachel Thakore, Wenjing Zheng, Stephanie Post, Colin S Brent, Sheng Li, Marc Tatar, Hua Bai
Transcriptional coordination is a vital process contributing to metabolic homeostasis. As one of the key nodes in the metabolic network, the forkhead transcription factor FOXO has been shown to interact with diverse transcription co-factors and integrate signals from multiple pathways to control metabolism, oxidative stress response, and cell cycle. Recently, insulin/FOXO signaling has been implicated in the regulation of insect development via the interaction with insect hormones, such as ecdysone and juvenile hormone...
November 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29180509/subcellular-localisation-of-the-stem-cell-markers-oct4-sox2-nanog-klf4-and-c-myc-in-cancer-a-review
#17
Bede van Schaijik, Paul F Davis, Agadha C Wickremesekera, Swee T Tan, Tinte Itinteang
The stem cell markers octamer-binding transcription factor 4, sex-determining region Y-box 2, NANOG, Kruppel-like factor 4 and c-MYC are key factors in inducing pluripotency in somatic cells, and they have been used to detect cancer stem cell subpopulations in a range of cancer types. Recent literature has described the subcellular localisation of these markers and their potential implications on cellular function. This is a relatively complex and unexplored area of research, and the extent of the effect that subcellular localisation has on cancer development and growth is largely unknown...
November 27, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29179208/klf-15-works-as-an-early-anti-fibrotic-transcriptional-regulator-in-ang-ii-induced-renal-fibrosis-via-down-regulation-of-ctgf-expression
#18
Xiangchen Gu, Dechao Xu, Lili Fu, Yi Wang, Changlin Mei, Xiang Gao
BACKGROUND/AIMS: Angiotensin II (Ang II) has been regarded as an important profibrogenic cytokine in renal fibrosis. Krüppel-like factor 15 (KLF15) has been identified as an important negative transcription factor in renal fibrosis. However, little is known about the role of KLF15 in Ang II-induced renal fibrosis. METHODS: In this study, we randomized mice into a control group, Ang II group or Ang II plus losartan group. KLF15 expression was examined with real-time PCR and immunofluorescence in these groups...
November 27, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29165700/epigenetic-therapy-novel-translational-implications-for-arrest-of-environmental-dioxin-induced-disease-in-females
#19
Zaraq Khan, Ye Zheng, Tiffanny L Jones, Abigail A Delaney, Luiz F Correa, Chandra C Shenoy, Khashayarsha Khazaie, Gaurang S Daftary
Increased toxicant exposure and resultant environmentally-induced diseases are a tradeoff of industrial productivity. Dioxin (TCDD: 2,3,7,8 tetrachlorodibenzo-p-dioxin), a ubiquitous by-product is associated with a spectrum of diseases including endometriosis, a common, chronic disease in women. TCDD activates cytochrome p450 (CYP) metabolic enzymes, which alters organ function to cause disease. In contrast, the transcription factor, Krüppel-Like Factor (KLF) 11 represses these enzymes via epigenetic mechanisms...
November 17, 2017: Endocrinology
https://www.readbyqxmd.com/read/29163009/regulatory-pathways-of-monoamine-oxidase-a-during-social-stress
#20
REVIEW
Yuki Higuchi, Tomoko Soga, Ishwar S Parhar
Social stress has a high impact on many biological systems in the brain, including serotonergic (5-HT) system-a major drug target in the current treatment for depression. Hyperactivity of hypothalamic-pituitary-adrenal (HPA) axis and monoamine oxidase A (MAO-A) are well-known stress responses, which are involved in the central 5-HT system. Although, many MAO-A inhibitors have been developed and used in the therapeutics of depression, effective management of depression by modulating the activity of MAO-A has not been achieved...
2017: Frontiers in Neuroscience
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