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Cerebral diffuse large B cell lymphoma

David Bell, David Marshman
We describe the case of a 70-year-old man with Marfan Syndrome who was found to have Diffuse Large B Cell Lymphoma (DLBCL) within an ascending aortic graft, his native aortic arch and arch vessels. Ten years previously he had undergone a Bentall's Procedure for a dilated aortic root. He presented with a left middle cerebral artery stroke. Computed tomography (CT) scan revealed multiple filling defects within the aortic arch and branch vessels suggestive of thrombus. Following the stroke, his neurological deficit improved...
February 2017: Heart, Lung & Circulation
Ching Chung Ko, Ming Hong Tai, Chien Feng Li, Tai Yuan Chen, Jeon Hor Chen, Ginger Shu, Yu Ting Kuo, Yu Chang Lee
The differentiation between glioblastoma multiforme (GBM) and primary cerebral lymphoma (PCL) is important because the treatments are substantially different. The purpose of this article is to describe the MR imaging characteristics of GBM and PCL with emphasis on the quantitative ADC analysis in the tumor necrosis, the most strongly-enhanced tumor area, and the peritumoral edema. This retrospective cohort study collected 104 GBM (WHO grade IV) patients and 22 immune-competent PCL (diffuse large B cell lymphoma) patients...
2016: PloS One
Lina Savsek, Tanja Ros Opaskar
BACKGROUND: Toxoplasmosis is an opportunistic protozoal infection that has, until now, probably been an underestimated cause of encephalitis in patients with hematological malignancies, independent of stem cell or bone marrow transplant. T and B cell depleting regimens are probably an important risk factor for reactivation of a latent toxoplasma infection in these patients. CASE REPORT: We describe a 62-year-old HIV-negative right-handed Caucasian female with systemic diffuse large B cell lymphoma who presented with sudden onset of high fever, headache, altered mental status, ataxia and findings of pancytopenia, a few days after receiving her final, 8(th) cycle of rituximab, cyclophosphamide, vincristine, doxorubicin, prednisolone (R-CHOP) chemotherapy regimen...
March 1, 2016: Radiology and Oncology
Hugo Ja Adams, John Mh de Klerk, Rob Fijnheer, Ben Gf Heggelman, Stefan V Dubois, Rutger Aj Nievelstein, Thomas C Kwee
BACKGROUND: There is a lack of data on the effect of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy on brain glucose metabolism of diffuse large B-cell lymphoma (DLBCL) patients, as measured by 18F-fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET). Moreover, the prognostic value of brain glucose metabolism measurements is currently unknown. PURPOSE: To investigate the use of FDG-PET for measurement of brain glucose metabolism in R-CHOP-treated DLBCL patients, and to assess its prognostic value...
June 2016: Acta Radiologica
Manuel Montesinos-Rongen, Frauke G Purschke, Anna Brunn, Caroline May, Eckhard Nordhoff, Katrin Marcus, Martina Deckert
Primary lymphoma of the CNS (PCNSL) is a diffuse large B cell lymphoma confined to the CNS. To elucidate its peculiar organ tropism, we generated recombinant Abs (recAbs) identical to the BCR of 23 PCNSLs from immunocompetent patients. Although none of the recAbs showed self-reactivity upon testing with common autoantigens, they recognized 1547 proteins present on a large-scale protein microarray, indicating polyreactivity. Interestingly, proteins (GRINL1A, centaurin-α, BAIAP2) recognized by the recAbs are physiologically expressed by CNS neurons...
August 1, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
Elizabeth Kouzmitcheva, Claude Steriade, Anca Prica, Lili-Naz Hazrati, Daniel M Mandell
No abstract text is available yet for this article.
June 9, 2015: Neurology
Heledd Lewis, Ali Jassem Mahdi, Clare Rowntree
We report the case of a previously well 58-year-old man who presented with headache and confusion 4 days postadministration of intrathecal methotrexate. He was undergoing intensive chemotherapy (CODOX-M/IVAC, cyclophosphamide, doxorubicin, vincristine, methotrexate, etoposide, ifosfamide, cytarabine) for the treatment of leukaemic phase CD20 negative diffuse large B-cell lymphoma. A CT of the head demonstrated the presence of bilateral subdural hygromas complicated by haemorrhage resulting from coexisting chemotherapy induced thrombocytopenia...
2015: BMJ Case Reports
Jensen W J Ang, Arjun Khanna, Brian P Walcott, Kristopher T Kahle, Emad N Eskandar
We describe an atypical man with diffuse large B cell lymphoma localized to the sphenoid wing and adjacent cavernous sinus, initially presenting with isolated ipsilateral facial pain mimicking trigeminal neuralgia due to invasion of Meckel's cave but subsequently progressing to intra-axial extension and having synchronous features of systemic lymphoma. Primary central nervous system lymphoma is uncommon, accounting for approximately 2% of all primary intracranial tumors, but its incidence has been steadily increasing in some groups [1]...
July 2015: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Akihiko Mitsutake, Tadahisa Kanemoto, Youji Suzuki, Naoki Sakai, Ken Kuriki
A 66-year-old woman presented with vertigo and deafness. Diffusion-weighted magnetic resonance imaging of the head showed multiple cerebral infarctions involving several blood vessel regions. A diagnosis of cardiogenic embolism was made, and anticoagulation therapy was begun. The woman had no additional symptoms until suddenly developing left hemiparesis one year later. She was again found to have multiple cerebral infarctions. The hemiparesis gradually improved, but ataxic gait and apraxia appeared and progressed over two weeks...
2015: Rinshō Shinkeigaku, Clinical Neurology
Zhaohua Gong, Ying Zhang, Hongjin Chu, Peiwen Lian, Liangming Zhang, Ping Sun, Jian Chen
Primary penile lymphoma presenting with priapism as the initial symptom is extremely rare. In total, <10 cases have been previously reported. The diagnosis can be difficult and patients often develop metastasis. The current study reports the case of a 48-year-old male, who presented with a one-month history of painless priapism. On admission to Yantai Yuhuangding Hospital Affiliated to Qingdao University (Yantai, China), examination revealed an erect penis, enlarged lymph nodes in the bilateral inguinal and swelling in the thighs...
November 2014: Oncology Letters
Huseyin Mertsoylu, Sadik Muallaoglu, Ayberk Ali Besen, Suleyman Erdogdu, Ahmet Sezer, Ali Murat Sedef, Fatih Kose, Ali Arican, Ozgur Ozyilkan
BACKGROUND: The aim of this study was to assess the epidemiological and clinicopathological characteristics of primary extranodal non-Hodgkin's lymphoma (pENL) patients, focusing on treatment and survival outcome. MATERIALS AND METHODS: Between October 2003 and March 2012, 802 patients with non-Hodgkin's lymphoma (NHL) were diagnosed and treated in two different cancer centers of Southern Turkey. RESULTS: pENL, constituted 12.4% (100/802) of all NHL studied during this period...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
Eugene J Teoh, Alexander L Green, Kevin M Bradley
No abstract text is available yet for this article.
November 2014: International Journal of Hematology
Masanari Nonokuma, Yasuo Kuwabara, Koichi Takano, Kazuo Tamura, Kenji Ishitsuka, Kengo Yoshimitsu
OBJECTIVES: The aim of this study was to clarify the characteristics of regional cerebral glucose metabolic abnormalities in patients with malignant lymphoma of the body using statistical image analyses. Post-therapeutic changes in cerebral glucose metabolism were also evaluated. METHODS: The subjects consisted of 30 patients, including 16 patients with diffuse large B-cell lymphoma and 14 patients with other types of lymphoma. Patients with primary cerebral lymphoma were excluded from this study...
December 2014: Annals of Nuclear Medicine
Kimberly Funaro, Katie C Bailey, Sadie Aguila, Steven J Agosti, Christopher Vaillancourt
We report a case of primary central nervous system lymphoma presenting as multiple intraventricular masses in an immunocompetent 68 year old man with severe headache and unsteady gait. The diagnosis was obtained by analysis of the cerebrospinal fluid and subsequent surgical biopsy. This is an unusual appearance for primary central nervous lymphoma, with the majority of the cases presenting as solitary masses.
March 2014: Journal of Radiology Case Reports
Myeong-Jin Ko, Sung-Nam Hwang, Yong-Sook Park, Teak Kyun Nam
Bone involvement is a common finding in many types of lymphomas, particularly in advanced stages. However, cranial vault affliction has been regarded as an exceedingly rare presentation. Here, we report the case of a patient with cranial vault lymphoma who presented with a scalp mass. An 81-year-old woman presented with a gradually growing and non-painful frontal scalp mass that she noticed one month before admission. It was a flatly elevated, round mass measuring about 6×4×4 cm. Computed tomography and magnetic resonance imaging of the brain revealed a contrast-enhancing intracranial extradural mass at the counter-location of the scalp mass...
April 2013: Brain Tumor Research and Treatment
Katharina Leitmeyer, Yves Brand, Claudio Storck
No abstract text is available yet for this article.
April 23, 2014: Praxis
Aneel Myageri, U G Vandana, Sateesh Melkundi, Preetam B Patil, Padmaja Kulkarni
The diagnosis of primary central nervous system lymphoma (PCNSL) can be suggested by magnetic resonance imaging (MRI). Cerebral PCNSL in immunocompetent patients generally shows marked homogeneous contrast enhancement in MRI. However, confirmation of it requires demonstration of lymphoma cells in stereotactic biopsy of the lesion or in cerebrospinal fluid. In the present case, with radiologic diagnosis of glioma, complete resection of the lesion by micro-neurosurgical technique was performed. The tumor tissue was examined by squash smear, frozen section and paraffin sections...
October 2013: Asian Journal of Neurosurgery
Aya Morimoto, Hiroki Ueno, Hiroki Fujii, Takeshi Nakamura, Kazuo Nakamichi, Masayuki Saijo, Motohiro Yukitake, Masayasu Matsumoto
A 57-year-old woman presented with motor and cognitive impairments under treatment for cryptogenic organizing pneumonia with immunosuppressive agents. Magnetic resonance imaging showed widespread signal abnormalities in the cerebral white matter. Susceptibility-weighted imaging showed attenuated contrast of the cerebral medullary vein in the lesions, and (18)F-fluorodeoxyglucose-positron emission tomography ((18)F-FDG-PET) revealed decreased uptake at the same site and increased uptake in multifocal lung involvements...
2013: Rinshō Shinkeigaku, Clinical Neurology
Shiro Yamamoto, Seiji Nagano, Sumiya Shibata, Takeharu Kunieda, Yukihiro Imai, Nobuo Kohara
A 66-year-old man presented with deteriorated bradykinesia, gait disturbance, disorientation, and urinary incontinence for three weeks. Magnetic resonance imaging (MRI) showed dilatation of the ventricles. Cerebrospinal fluid (CSF) examination demonstrated lymphocytic pleocytosis, elevation of protein levels, and decreased of glucose levels. A gadolinium-enhanced MRI revealed lesions in the ventricular wall and choroid plexus, mimicking ventriculitis. No evidence of bacterial, fungal, mycobacterial, or viral infections were observed in the CSF...
2013: Rinshō Shinkeigaku, Clinical Neurology
Jinfeng Zheng, Jiagang Xu, Shufang Ma, Xiyan Sun, Ming Geng, Lin Wang
We studied the clinicopathological and imaging characteristics of primary central nervous system diffuse large B-cell lymphomas (PCNS-DLBCL). Imaging, pathologic histology, and immunohistochemical staining characteristics were analyzed, and the immunoglobulin heavy and light chain gene rearrangement of 25 PCNS-DLBCL cases was examined. MicroRNA was extracted from 10 cases each of PCNS-DLBCL, extracerebral germinal center DLBCL (GC-DLBCL), and extracerebral non-GC-DLBCL (NGC-DLBCL); we conducted chip hybridization and comparatively analyzed the difference among the three...
2013: International Journal of Clinical and Experimental Pathology
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