Annarita Conconi, Annalisa Chiappella, Andrés Jm Ferreri, Anastasios Stathis, Barbara Botto, Marianna Sassone, Gianluca Gaidano, Monica Balzarotti, Francesco Merli, Alessandra Tucci, Anna Vanazzi, Monica Tani, Riccardo Bruna, Lorella Orsucci, Maria Giuseppina Cabras, Melania Celli, Ombretta Annibali, Anna Marina Liberati, Manuela Zanni, Chiara Ghiggi, Francesco Pisani, Graziella Pinotti, Fausto Dore, Fabiana Esposito, Maria Cristina Pirosa, Marina Cesaretti, Luisella Bonomini, Umberto Vitolo, Emanuele Zucca
Primary testicular diffuse large B-cell lymphoma (PTL) is characterized by high-risk of contralateral testis and central nervous system (CNS) relapse. Chemoimmunotherapy with intrathecal (IT) CNS prophylaxis and contralateral testis irradiation eliminates contralateral recurrences and reduces the CNS relapses. The IELSG30 phase II study (ClinicalTrials.gov NCT00945724) investigated feasibility and activity of an intensified IT and intravenous (IV) CNS prophylaxis. Untreated patients with stage I-II PTL received 2 cycles of IV high-dose methotrexate (MTX) (1...
January 4, 2024: Blood Advances