keyword
Keywords Diffuse large B cell lymphoma ...

Diffuse large B cell lymphoma cerebral

https://read.qxmd.com/read/38487325/case-report-acute-hhv6b-encephalitis-myelitis-post-car-t-cell-therapy-in-patients-with-relapsed-refractory-aggressive-b-cell-lymphoma
#1
Ningwen Li, Ruoxuan Zhang, Jue Wang, Xiaojian Zhu, Fankai Meng, Yang Cao, Gaoxiang Wang, Yang Yang
BACKGROUND: The development of chimeric antigen receptor (CAR)-T cell therapy has revolutionized treatment outcomes in patients with lymphoid malignancies. However, several studies have reported a relatively high rate of infection in adult patients following CD19-targeting CAR T-cell therapy, particularly in the first 28 days. Notably, acute human herpesvirus 6 B (HHV6B) reactivation occurs in up to two-thirds of allogeneic hematopoietic stem cell transplantation patients. CASE PRESENTATIONS: Herein, we describe a report of HHV6B encephalitis/myelitis in three patients with relapsed/refractory diffuse large B-cell lymphoma post CAR T-cell therapy...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38445428/cerebral-venous-thrombosis-after-first-methotrexate-administration-by-lumbar-puncture-in-a-patient-with-large-b-cell-lymphoma
#2
JOURNAL ARTICLE
Aicha Ben Kahla, Olfa Kassar, Khadija Moalla, Yosra Fakhfakh, Yosr Hentati, Moez Elloumi
Cerebral venous thrombosis is a rare consequence of lumbar punctures for intrathecal therapy. We report a patient treated for diffuse large B cell lymphoma with cerebral venous thrombosis after intrathecal Methotrexate administration. In this patient, intrathecal treatment was discontinued and he was successfully treated with high-dose low-molecular-weight heparin subcutaneously. Haematologist must be aware about neurological symptoms of cerebral venous thrombosis as a complication of lumbar puncture especially among patients with high coagulopathy state...
July 5, 2023: La Tunisie Médicale
https://read.qxmd.com/read/38406545/trousseau-s-syndrome-in-diffuse-large-b-cell-lymphoma
#3
JOURNAL ARTICLE
Wataru Kitamura, Yumiko Sato, Shoichi Kuyama
No abstract text is available yet for this article.
February 2024: EJHaem
https://read.qxmd.com/read/38384697/dural-based-large-b-cell-lymphoma-masquerading-as-a-tentorial-meningioma
#4
Kasumi Inami, Satoshi Tsutsumi, Akane Hashizume, Motoki Yamataka, Natsuki Sugiyama, Hideaki Ueno, Hisato Ishii
A 53-year-old woman presented with a 2-week history of headache and vertigo. Computed tomography revealed a hyperdense tumor, measuring 30 × 31 × 36 mm in diameter, in the anteromedial parts of the cerebellar hemispheres. Cerebral magnetic resonance imaging 10 days later revealed an apparent extra-axial tumor with broad attachment to the medial tentorium cerebelli and rapid growth to a diameter of 40 × 41 × 46 mm. Cerebral angiography revealed no obvious feeding vessels or tumor stains. The patient underwent biopsy through the left occipital transtentorial route...
May 2024: Radiology Case Reports
https://read.qxmd.com/read/38321466/internuclear-ophthalmoplegia-as-a-presentation-of-procedural-stroke-a-case-report
#5
JOURNAL ARTICLE
Norachai Sirisreetreerux, Krongkamol Ponglikitmongkol
BACKGROUND: Cardiac catheterization and endovascular procedures are extensively used in modern medicine, and procedural stroke is one of the major complications that the catheterization laboratory team may face in their everyday work. Recognizing the signs and symptoms of procedural stroke is crucial to ensuring appropriate management. We herein report a case of internuclear ophthalmoplegia that caused blurred vision, diplopia, and dizziness on lateral gaze as an unusual presentation of procedural stroke...
February 7, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38181782/ielsg30-phase-2-trial-intravenous-and-intrathecal-cns-prophylaxis-in-primary-testicular-diffuse-large-b-cell-lymphoma
#6
JOURNAL ARTICLE
Annarita Conconi, Annalisa Chiappella, Andrés Jm Ferreri, Anastasios Stathis, Barbara Botto, Marianna Sassone, Gianluca Gaidano, Monica Balzarotti, Francesco Merli, Alessandra Tucci, Anna Vanazzi, Monica Tani, Riccardo Bruna, Lorella Orsucci, Maria Giuseppina Cabras, Melania Celli, Ombretta Annibali, Anna Marina Liberati, Manuela Zanni, Chiara Ghiggi, Francesco Pisani, Graziella Pinotti, Fausto Dore, Fabiana Esposito, Maria Cristina Pirosa, Marina Cesaretti, Luisella Bonomini, Umberto Vitolo, Emanuele Zucca
Primary testicular diffuse large B-cell lymphoma (PTL) is characterized by high-risk of contralateral testis and central nervous system (CNS) relapse. Chemoimmunotherapy with intrathecal (IT) CNS prophylaxis and contralateral testis irradiation eliminates contralateral recurrences and reduces the CNS relapses. The IELSG30 phase II study (ClinicalTrials.gov NCT00945724) investigated feasibility and activity of an intensified IT and intravenous (IV) CNS prophylaxis. Untreated patients with stage I-II PTL received 2 cycles of IV high-dose methotrexate (MTX) (1...
January 4, 2024: Blood Advances
https://read.qxmd.com/read/38078513/csf-cytology-of-common-primary-cns-neoplasms-categorized-by-cns-who-2021
#7
JOURNAL ARTICLE
Mohammad Salimian, Angela N Viaene, Jason Chang, Cheng-Ying Ho
OBJECTIVE: The detection of neoplastic cells in cerebral spinal fluid (CSF) is pivotal for the management of patients with central nervous system (CNS) tumours. This article delves into the CSF cytological characteristics of common CNS neoplasms, aligning with the 2021 World Health Organization (WHO) classification of CNS tumours. METHODS: A retrospective review of CSF specimens positive for primary CNS neoplasms was performed at three tertiary medical centres. Only cases that had histopathologic confirmation and/or molecular workup were included...
December 11, 2023: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://read.qxmd.com/read/38067268/involved-site-radiation-therapy-enables-effective-disease-control-in-parenchymal-low-grade-primary-cerebral-lymphoma
#8
JOURNAL ARTICLE
Niklas Benedikt Pepper, Michael Oertel, Gabriele Reinartz, Khaled Elsayad, Dominik Alexander Hering, Fatih Yalcin, Moritz Wildgruber, Walter Stummer, Georg Lenz, Wolfram Klapper, Hans Theodor Eich
BACKGROUND: Primary lymphoma of the central nervous system (PCNSL) encompasses a variety of lymphoma subtypes, with the majority being diffuse large B-cell lymphomas, which require aggressive systemic treatment. In contrast, low-grade lymphomas are reported infrequently and are mostly limited to dural manifestations. Very rarely, parenchymal low-grade PCNSL is diagnosed, and the cases documented in the literature show a wide variety of treatment approaches. METHODS: We screened all cases of PCNSL treated at our department (a tertiary hematooncology and neurooncology center) in the last 15 years and conducted a comprehensive literature research in the PubMed database...
November 24, 2023: Cancers
https://read.qxmd.com/read/37902852/the-remodeling-of-metabolic-brain-pattern-in-patients-with-extracranial-diffuse-large-b-cell-lymphoma
#9
JOURNAL ARTICLE
Junyi Liu, Ming Tang, Dongling Zhu, Ge Ruan, Sijuan Zou, Zhaoting Cheng, Xiaohua Zhu, Yuankai Zhu
BACKGROUND: Owing to the advances in diagnosis and therapy, survival or remission rates for lymphoma have improved prominently. Apart from the lymphoma- and chemotherapy-related somatic symptom burden, increasing attention has been drawn to the health-related quality of life. The application of 18 F-fluorodeoxyglucose positron emission tomography-computed tomography (18 F-FDG PET/CT) has been routinely recommended for the staging and response assessment of FDG-avid lymphoma. However, up till now, only a few researches have investigated the brain metabolic impairments in patients with pre-treatment lymphoma...
October 30, 2023: EJNMMI Research
https://read.qxmd.com/read/37811052/a-cerebral-lymphoma-mimicking-a-meningioma-case-report
#10
Imane Joudar, Siham Nasri, Narjisse Aichouni, Imane Kamaoui, Imane Skiker
INTRODUCTION: Cerebral lymphoma is a rare and aggressive brain tumor. It accounts for 1% of all non-Hodgkin's lymphomas (NHL) and 2% of all brain tumors. Untreated brain lymphoma has a very poor prognosis, with an overall life expectancy of around 1.5 months. CASE PRESENTATION: The authors report the case of a 35-year-old patient, with no previous pathological history, who presented for 3 weeks with deafness and recently aggravated otalgia. In MRI, brain imaging revealed a formation initially suggestive of an aggressive meningioma, and the histological study of the operative specimen was in favor of a diffuse large-cell non-germ-center B NHL...
October 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/37679606/different-patterns-of-failure-in-two-treatment-regimens-for-primary-central-nervous-system-lymphoma-a-retrospective-analysis-of-124-cases-in-taiwan
#11
JOURNAL ARTICLE
Chin-Hsuan Chuang, Ming-Chung Kuo, Hung Chang, Jin-Hou Wu, Yu-Shin Hung, Che-Wei Ou, Tung-Liang Lin, Yi-Jiun Su, Yuen-Chin Ong, Lee-Yung Shih, Hsiao-Wen Kao
To explore prognostic factors and outcomes of primary central nervous system lymphoma (PCNSL) of diffuse large B-cell lymphoma (DLBCL) in Taiwan, 124 PCNSL-DLBCL patients (from 1995 to 2021) were retrospectively analyzed. Mainly, two treatment modalities including sandwich chemoradiotherapy and modified MATRix regimen were employed in these patients. Overall survival (OS) was determined by log-rank test and time-dependent Cox analysis. Median OS of all patients was 27.1 months. 47 (37.9%) patients who underwent sandwich chemoradiotherapy had a complete remission (CR) rate of 87...
September 7, 2023: Clinical and Experimental Medicine
https://read.qxmd.com/read/37554475/primary-central-nervous-system-lymphoma-complicated-by-cerebral-venous-sinus-thrombosis-a-case-report
#12
JOURNAL ARTICLE
Teresa Medeiros, Sofia Sequeira, Manuela Mendes, Fátima Hierro, Sara Duarte
UNLABELLED: Central nervous system (CNS) lymphoma is a rare and aggressive primary neoplasm that comprises a small proportion of brain tumours and non-Hodgkin lymphomas. We present a case report of a 64-year-old woman with CNS lymphoma, who exhibited cognitive changes, weight loss and neurological symptoms. Imaging scans revealed multiple lesions in the brain and thrombosis in the venous sinuses. A diagnosis of diffuse large B-cell lymphoma of the CNS was confirmed through histological examination...
2023: European Journal of Case Reports in Internal Medicine
https://read.qxmd.com/read/37462774/-18f-fdg-pet-mri-provides-survival-biomarkers-in-primary-central-nervous-system-lymphoma-in-the-elderly-an-ancillary-study-from-the-blocage-trial-of-the-loc-network
#13
JOURNAL ARTICLE
Laura Rozenblum, Damien Galanaud, Caroline Houillier, Carole Soussain, Amandine Baptiste, Lisa Belin, Véronique Edeline, Philippe Naggara, Marine Soret, Valérie Causse-Lemercier, Lise Willems, Sylvain Choquet, Renata Ursu, Khê Hoang-Xuan, Aurélie Kas
PURPOSE: Primary central nervous system lymphoma (PCNSL) incidence is rising among elderly patients, presenting challenges due to poor prognosis and treatment-related toxicity risks. This study explores the potential of combining [18F]fluorodeoxyglucose ([18F]FDG) PET scans and multimodal MRI for improving management in elderly patients with de novo PCNSL. METHODS: Immunocompetent patients over 60 years with de novo PCNSL were prospectively enrolled in a multicentric study between January 2016 and April 2021...
July 18, 2023: European Journal of Nuclear Medicine and Molecular Imaging
https://read.qxmd.com/read/37302774/cns-nocardiosis-mimicking-recurrence-of-dlbcl-with-cerebral-involvement
#14
JOURNAL ARTICLE
Graeme A Fenton, Grant Banfill, Kriti Gera, Robert P Seifert, Coy D Heldermon
No abstract text is available yet for this article.
June 9, 2023: International Journal of Infectious Diseases: IJID
https://read.qxmd.com/read/36970234/a-case-of-intravascular-lymphoma-presenting-with-a-lesion-in-the-splenium-of-the-corpus-callosum
#15
Haruka Masuzawa, Fumio Suzuki, Shiori Amemiya, Kenta Orimo, Hiroyuki Ishiura, Ryo Hara, Tatsushi Toda, Teruo Nakazawa, Akira Honda, Mariko Tanaka, Munetoshi Hinata, Osamu Abe
Intravascular lymphoma (IVL) is difficult to diagnose because its clinical presentation and laboratory and imaging findings are nonspecific. Herein, we report a case of IVL presenting as a lesion in the splenium of the corpus callosum. A 52-year-old man attended the emergency department with a 2-week history of progressively worsening abnormal behavior and gait disturbance. Magnetic resonance imaging on admission revealed an oval lesion in the splenium of the corpus callosum. The follow-up magnetic resonance imaging performed 2 months after disease onset revealed multiple high-signal areas in the bilateral cerebral white matter on T2-weighted images and diffusion-weighted images...
May 2023: Radiology Case Reports
https://read.qxmd.com/read/36712581/successful-cns-centric-therapeutic-management-and-genomic-profiling-of-primary-cranial-vault-diffuse-large-b-cell-lymphoma
#16
Jordan Davis, ErinMarie O Kimbrough, Muhamad Alhaj Moustafa, Liuyan Jiang, Vivek Gupta, Ephraim Parent, Han W Tun
Primary cranial vault lymphoma (PCVL) is a rare lymphoma involving the skull with or without extra- and intracranial extension. Most cases of PCVL are diffuse large B-cell lymphoma (DLBCL). We report a case of primary cranial vault diffuse large B-cell lymphoma (PCV-DLBCL) that was successfully treated with anthracycline-based chemoimmunotherapy (CIT) alternating with central nervous system (CNS)-directed CIT with high-dose methotrexate and high-dose cytarabine. CNS-centric therapy was given for suspected cerebral cortical involvement and presumed elevated risk of CNS recurrence...
2023: Journal of Blood Medicine
https://read.qxmd.com/read/36599976/inflammatory-brain-lesions-preceding-primary-central-nervous-system-lymphoma-a-case-report-and-genetic-analysis
#17
REVIEW
Zheng XiaoHong, Yin Shuo, Dong GeHong, Yang AnChao, Wang Ce, Duan YunYun, Wang Can, Huang SiJie, Chen Feng, Li WenBin
BACKGROUND: Primary central nervous system lymphoma (PCNSL) is an aggressive extranodal lymphoma exclusively occurring within the central nervous system. Inflammatory brain lesions as "sentinel lesions" of PCNSL are very rare. We present a rare case of PCNSL with preceding inflammatory lesions in an immunocompetent patient who underwent two biopsies, one craniotomy and two genetic testing. CASE REPORT: A 66-year-old male patient presented with left limb weakness and ataxia...
January 5, 2023: Neurological Sciences
https://read.qxmd.com/read/36536911/preliminary-clinical-application-of-multimodal-imaging-combined-with-frameless-robotic-stereotactic-biopsy-in-the-diagnosis-of-primary-central-nervous-system-lymphoma
#18
JOURNAL ARTICLE
Yong Tang, Yan Shi, Ling Wang, Zheng-Ting Qian, You-Wu Fan, He-Ming Wu, Xiang Li
OBJECTIVE: To evaluate the clinical application of multimodal imaging combined with frameless robotic stereotactic biopsy in the diagnosis of primary central nervous system lymphoma (PCNSL). METHODS: We retrospectively reviewed the clinical data of 8 patients who were considered suspected cases of PCNSL by multimodal imaging techniques. The final pathologic diagnosis were determined by the frameless robotic stereotactic biopsy. The postoperative related complications and pathological results were analyzed...
December 2022: Heliyon
https://read.qxmd.com/read/36351644/-long-term-complete-remission-of-hiv-negative-primary-testicular-plasmablastic-lymphoma-treated-with-bortezomib-in-combination-with-epoch
#19
JOURNAL ARTICLE
Takashi Fujishima, Yoshinari Kawabata, Yoshihiro Michishita, Atushi Kitabayashi, Naoto Takahashi
Plasmablastic lymphoma (PBL) is a rare variant of diffuse large B-cell lymphoma that is frequently associated with HIV infection or other immunodeficiencies. We present a case of HIV-negative primary testicular PBL with long-term complete remission (CR) and successful treatment with bortezomib in combination with EPOCH (V-EPOCH). Because of rapidly increasing right testicular swelling, an 86-year-old man without immunodeficiencies was admitted to our hospital. Following that, a right high orchiectomy was performed...
2022: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://read.qxmd.com/read/36274600/-imaging-and-cerebrospinal-fluid-features-of-two-cases-with-lymphomatosis-cerebri
#20
JOURNAL ARTICLE
B Chen, S T Niu, Y Z Shi, X G Wang, G H Dong, H G Liu, Z Q Zhang
This article reported the clinical experience of diagnosis and treatment for two patients with lymphomatosis cerebri. Case 1 was female and aged 53 years old, while case 2 was male and aged 69 years old. Progressive cognitive impairment was the main clinical manifestation in both patients. Brain magnetic resonance imaging (MRI) suggested leukoencephalopathy with patchy or mass enhancement. Cerebral blood flow was reduced on perfusion imaging in one patient. Brain biopsy confirmed diffuse large B-cell lymphoma in both cases...
October 25, 2022: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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