Meng Cong, Jiyu Li, Lijuan Wang, Chang Liu, Mengru Zheng, Qiang Zhou, Mingzhi Du, Xinli Ye, Min Feng, Yujiao Ye, Shuyu Zhang, Wenqing Xu, Yi Lu, Cheng Wang, Yingjie Xia, Huimin Xie, Yide Zhang, Qianru He, Leilei Gong, Yun Gu, Hualin Sun, Qi Zhang, Jian Zhao, Fei Ding, Xiaosong Gu, Songlin Zhou
Nerve injury often leads to severe dysfunction because of the lack of axon regeneration in adult mammal. Intriguingly a series of extracellular vesicles (EVs) have the obvious ability to accelerate the nerve repair. However, the detailed molecular mechanisms to describe that EVs switch neuron from a transmitter to a regenerative state have not been elucidated. This study elucidated the microRNA (miRNA) expression profiles of two types of EVs that promote nerve regeneration. The functions of these miRNAs were screened in vitro...
March 14, 2024: Experimental Neurology