Maysa Alves Rodrigues Brandao-Rangel, Renilson Moraes-Ferreira, Anamei Silva-Reis, Victor Hugo Souza-Palmeira, Francine Maria Almeida, Fabiana Regina da Silva Olimpio, Carlos Rocha Oliveira, Nilsa Regina Damaceno-Rodrigues, João Bosco Pesquero, Leonardo Martin, Flavio Aimbire, Regiane Albertini, Sara Socorro Faria, Rodolfo P Vieira
INTRODUCTION: Aerobic physical training (APT) reduces eosinophilic airway inflammation, but its effects and mechanisms in severe asthma remain unknown. METHODS: An in vitro study employing key cells involved in the pathogenesis of severe asthma, such as freshly isolated human eosinophils, neutrophils, and bronchial epithelial cell lineage (BEAS-2B) and lung fibroblasts (MRC-5 cells), was conducted. Additionally, an in vivo study using male C57Bl/6 mice, including Control (Co; n = 10), Trained (Exe; n = 10), house dust mite (HDM; n = 10), and HDM + Trained (HDM + Exe; n = 10) groups, was carried out, with APT performed at moderate intensity, 5x/week, for 4 weeks...
April 10, 2024: Molecular Biology Reports